Nagamachi Akiko 長町安希子

Researcher Number	20585153
Affiliation (Current)	2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(機関長・部門長クラス)
Affiliation (based on the past Project Information) *help	2014 – 2024: 広島大学, 原爆放射線医科学研究所, 助教 2017: 広島大学, 原爆放射線医科学研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals / Hematology
Keywords	Principal Investigator 骨髄異形成症候群 / SAMD9/9L症候群 / MDS / Samd9/9L / Samd9/9L症候群 / 貧血 / 赤血球分化 / アザシチジン / 白血病 / 遺伝子 / -7/7q- / 骨髄異型性症候群 / ゲノム編集 … More Except Principal Investigator … More モノソミー７ / MDS / 造血障害 / Samd9/9L / Samd9／9L / 骨髄異形成症候群 / Samd9/L / エンドソーム / 次世代シーケンサー / 受精卵 / 放射線 / インターフェロン / Monosomo-7 / monosomy 7 / Samd9/9L症候群 / TGFbeta / 先天性造血不全症候群 / モノソミー7 / SAMD9/SAMD9L症候群 / エンドソーム交通 / 表面受容体代謝 / トランスフェリン / サイトカイン受容体 / 受容体代謝 / サイトカイン / 造血不全 / 低線量 / 低線量、低線量率 / 遺伝子改変マウス / 放射線発がん / 細胞老化 / 低線量・低線量率 / haploinsufficiency / Miki / Samd9 / 中心体成熟不全 / Haploinsufficiency / 細胞遊走能 / 7番染色体 / RAEB Less

SAMD9/9LによるTGFbetaシグナルを介したHSC静止期維持システムの解明Principal Investigator
- Principal Investigator
  
  長町安希子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
Molecular mechanisms through which SAMD9/9L mutants cause bone marrow failure
- Principal Investigator
  
  INABA Toshiya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
Functional analysis of SAMD9/9L mutations in hematopoiesis and generation of a novel humanized SAMD9/9L mouse modelPrincipal Investigator
- Principal Investigator
  
  Nagamachi Akiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
Analysis of Trim43 in radiation-induced arrest of fertilized egg development
- Principal Investigator
  
  Kanai Akinori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  The University of Tokyo
Involvement of the translation machinery in the improvement of anemia in myelodysplastic syndromes by Aza-dCPrincipal Investigator
- Principal Investigator
  
  Nagamachi Akiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
Abnormal endosomal traffic induced by Samd9/9L causing myelodysplastic syndromes and inherited bone marrow failure
- Principal Investigator
  
  Inaba Toshiya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
A novel study on the mechanisms of low-dose radiation-induced aging and carcinogenesis
- Principal Investigator
  
  Kamiya Kenji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Characterizing the large chromosomal deletion in 7q- myelodysplastic syndrome using human iPS cells and the genome editing systemPrincipal Investigator
- Principal Investigator
  
  Nagamachi Akiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Elucidation of molecular mechanism through which MDS develops
- Principal Investigator
  
  Inaba Toshiya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Generation of mice models of AML/MDS with large genomic deletion using CRISPR/Cas9 genome editingPrincipal Investigator
- Principal Investigator
  
  Nagamachi Akiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Application of prime editing system to introduce P53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line2024
- Author(s)
  Nguyen Thao、Aida Tomomi、Iijima‐Yamashita Yuka、Tamai Minori、Nagamachi Akiko、Kagami Keiko、Komatsu Chiaki、Kasai Shin、Akahane Koshi、Goi Kumiko、Inaba Toshiya、Sanada Masashi、Inukai Takeshi
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 0-0
- DOI
  10.1111/cas.16162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-23K24298
[Journal Article] Ribosome profiling analysis reveals the roles of DDX41 in translational regulation2023
- Author(s)
  Tungalag Saruul、Shinriki Satoru、Hirayama Mayumi、Nagamachi Akiko、Kanai Akinori、Inaba Toshiya、Matsui Hirotaka
- Journal Title
  
  International Journal of Hematology
  
  Volume: - Issue: 6 Pages: 1-13
- DOI
  10.1007/s12185-023-03558-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-22K17187, KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21K08419
[Journal Article] Mouse models of hematological diseases using genome editing technology2022
- Author(s)
  長町安希子、稲葉俊哉
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 63 Issue: 11 Pages: 1551-1557
- DOI
  10.11406/rinketsu.63.1551
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21H02948
[Journal Article] DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells2022
- Author(s)
  Satoru Shinriki;Mayumi Hirayama;Akiko Nagamachi;Akihiko Yokoyama;Takeshi Kawamura;Akinori Kanai;Hidehiko Kawai;Junichi Iwakiri;Rin Liu;Manabu Maeshiro;Saruul Tungalag;Masayoshi Tasaki;Mitsuharu Ueda;Kazuhito Tomizawa;Naoyuki Kataoka;Takashi Ideue;Yutaka Suzuki;Kiyoshi Asai;Tokio Tani;Toshiya Inaba;Hirotaka Matsui
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 11 Pages: 2605-2620
- DOI
  10.1038/s41375-022-01708-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06174, KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-22K12375, KAKENHI-PROJECT-22K20997, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-20K12041, KAKENHI-PROJECT-23K24368
[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021
- Author(s)
  Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
- Journal Title
  
  Blood.
  
  Volume: 137 Issue: 7 Pages: 908-922
- DOI
  10.1182/blood.2019001044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
[Journal Article] Multi-organ failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes2021
- Author(s)
  Nagamachi A, Kanai A, Nakamura M, Okuda H, Yokoyama A, Shinriki S, Matsui H, Inaba T.
- Journal Title
  
  J Clin Invest
  
  Volume: 131 Issue: 4 Pages: 1-16
- DOI
  10.1172/jci140147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10360, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21K08395
[Journal Article] Revertant somatic mosaicism as a cause of cancer2021
- Author(s)
  Inaba Toshiya、Nagamachi Akiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 4 Pages: 1383-1389
- DOI
  10.1111/cas.14852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21K08395
[Journal Article] Effects of Radiation on Blood Pressure and Body Weight in the Spontaneously Hypertensive Rat Model. Are Radiation Effects on Blood Pressure Affected by Genetic Background?2020
- Author(s)
  105.Takahashi N, Misumi M, Niwa Y, Murakami H, Ohishi W, Inaba T, Nagamachi A, Tanaka S, Iii IBT, Suzuki G.
- Journal Title
  
  Radiat Res.
  
  Volume: in press Issue: 6 Pages: 552-552
- DOI
  10.1667/rr15536.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-18K08357
[Journal Article] Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL2020
- Author(s)
  Atsushi Watanabe, Kunio Miyake, Jessica Nordlund, Ann-Christine Syvanen, Louise van der Weyden, Hiroaki Honda, Norimasa Yamasaki, Akiko Nagamachi, Toshiya Inaba, Tomokatsu Ikawa, Kevin Y Urayama, Nobutaka Kiyokawa, Akira Ohara, Shunsuke Kimura, Yasuo Kubota, Junko Takita, Hiroaki Goto, Kimiyoshi Sakaguchi, et al.
- Journal Title
  
  Blood
  
  Volume: 136 Issue: 20 Pages: 2319-2333
- DOI
  10.1182/blood.2019004090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08318, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19KK0222, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-20H00528
[Journal Article] Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells.2019
- Author(s)
  Nagamachi A, Kikuchi J, Kanai A, Furukawa Y, Inaba T.
- Journal Title
  
  Haematologica
  
  Volume: in press Issue: 7 Pages: 1-14
- DOI
  10.3324/haematol.2019.232959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-17K09938, KAKENHI-PROJECT-20K08761
[Journal Article] A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.2018
- Author(s)
  Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 14 Issue: 2 Pages: e1006884-e1006884
- DOI
  10.1371/journal.ppat.1006884
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19575
[Journal Article] Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.2017
- Author(s)
  Nakata Y, Ueda U, Nagamachi A, Yamasaki N, Ikeda K, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda Z, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.2017
- Author(s)
  Ikeda K, Ueda T, Yamasaki N, Nakata Y,Sera Y, Nagamachi A,Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L, Honda Zi, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia2017
- Author(s)
  Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda ZI, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 129 Issue: 15 Pages: 2148-2160
- DOI
  10.1182/blood-2016-06-724658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-17K08679, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-17J05696, KAKENHI-PROJECT-16K19575
[Journal Article] Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency2016
- Author(s)
  Ikeda K-I, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, TakuboK, Kanai A, Oda H, Wolff l, Honda Z-1, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 29454-29454
- DOI
  10.1038/srep29454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16K19575
[Journal Article] Biological implication of somatic DDX41 p.R525H mutation in acute myeloid leukemia.2016
- Author(s)
  Kadono M, Kanai A, Nagamachi A, Shinriki S, Kawata J, Iwato K, Kyo T, Oshima K, Yokoyama A, Kawamura T, Nagase R, Inoue D, Kitamura T, Inaba T, Ichinohe T, Matsui H.
- Journal Title
  
  Exp. Hematol.
  
  Volume: 44(8) Issue: 8 Pages: 745-754
- DOI
  10.1016/j.exphem.2016.04.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K11726, KAKENHI-PROJECT-16K19575
[Journal Article] Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.2016
- Author(s)
  Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 20157-20157
- DOI
  10.1038/srep20157
- NAID
  120006796541
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-25253067, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670447, KAKENHI-PROJECT-26860735, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16K09791
[Journal Article] Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia.2016
- Author(s)
  Sera Y, Yamasaki N, Oda H, Nagamachi A, Wolff L, Inukai T, Inaba T, Honda H.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 7 Pages: 890-898
- DOI
  10.1111/cas.12945
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-15K09645, KAKENHI-PROJECT-16K19575
[Journal Article] Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.2016
- Author(s)
  Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 20157-20157
- NAID
  120006796541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia.2016
- Author(s)
  Sera Y, Yamasaki N, Oda H, Nagamachi A, Wolff L, Inukai T, Inaba T, Honda H.
- Journal Title
  
  Cancer Sci.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Propagation of tri-methylated H3K27 regulated by EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.2016
- Author(s)
  Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Matsui H, Honda ZI, Oda H, Wolff L, Inaba T, Honda H.
- Journal Title
  
  PNAS
  
  Volume: 113(37) Issue: 37 Pages: 10370-10375
- DOI
  10.1073/pnas.1600070113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K19575
[Journal Article] Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.2015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda ZI, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 125 Pages: 3437-3446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] -7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity.2015
- Author(s)
  Honda H, Nagamachi A, Inaba T.
- Journal Title
  
  Oncogene
  
  Volume: 34 Issue: 19 Pages: 2413-2425
- DOI
  10.1038/onc.2014.196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860735, KAKENHI-PROJECT-26293227
[Journal Article] SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.2015
- Author(s)
  Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 29(4) Issue: 4 Pages: 847-57
- DOI
  10.1038/leu.2014.301
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09414, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-26293231, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-26893051, KAKENHI-PROJECT-25461422, KAKENHI-PROJECT-26670465, KAKENHI-PROJECT-26860735
[Journal Article] SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.2015
- Author(s)
  Inoue D, Kitaura J, Matsui H, Hou H-A, Chou W-C, Nagamachi A, Kawabata K, Togami K, Nagase R, Horikawa S, Saika M, Micol J-B, Hayashi Y, Harada Y, Harada H, Inaba T, Tien H-F, Abdel-Wahab O, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 29 Pages: 847-857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Fbxl10 overexpression in murine hematopoietic stemcells induces leukemia involving metabolic activation and upregulation of Nsg22015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 22 Pages: 3437-3446
- DOI
  10.1182/blood-2014-03-562694
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26860735, KAKENHI-PROJECT-26293227
[Presentation] 骨髄機能低下をもたらすSamd9/9L変異体によるTGFbシグナル撹乱と静止期造血幹細胞の減少2023
- Author(s)
  長町安希子
- Organizer
  日本血液学会総会
- Data Source
  KAKENHI-PROJECT-21H02948
[Presentation] IBMF-causative Samd9/9L mutations increase cycling-HSC by disturbing TGFb signal transduction2023
- Author(s)
  Akiko Nagamachi, Akinori Kanai, Hirotaka Matsui, Satoru Shinriki, Tomokatsu Ikawa, Toshiya Inaba
- Organizer
  第85回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08395
[Presentation] Dysregulation of TGF-beta autocrine signals by a bone marrow failure-causative Samd9L mutant.2022
- Author(s)
  Akiko Nagamachi, Akinori Kanai, Hirotaka Matsui, Satoru Shinriki, Tomokatsu Ikawa, Toshiya Inaba
- Organizer
  第84回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08395
[Presentation] Involvement of IFNγ in the development of 7q-/MDS in patients with SAMD9/9L syndromes2021
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Satoru Shinriki, and Toshiya Inaba
- Organizer
  第83回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08395
[Presentation] Involvement of IFNγ in the development of 7q-/MDS in patients with SAMD9/9L syndromes2021
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Satoru Shinriki, and Toshiya Inaba
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08395
[Presentation] Abnormal endocytosis due to a Samd9L mutation causes bone marrow/multi-organ failure in mice mimicking MIRAGE syndrome2020
- Author(s)
  長町安希子
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08357
[Presentation] Abnormal receptor metabolism by Samd9/9L mutations is a cause of MIRAGE syndrome. Samd9/9L変異体による受容体取込み異常がMIRAGE症候群の骨髄・多臓器不全をもたらす2020
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Satoru Shinriki, Toshiya Inaba.
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Abnormal endocytosis due to a Samd9L mutation causes bone marrow/multi-organ failure in mice mimicking MIRAGE syndrome2020
- Author(s)
  長町安希子
- Organizer
  第82回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08357
[Presentation] Internalization speed of surface cytokine receptors is critical for hematopoietic cell growth. サイトカイン受容体取込み速度が造血細胞の競合に与える影響：モノソミー７を有するMDSの発症機序2020
- Author(s)
  Toshiya Inaba, Akiko Nagamachi, Akinori Kanai, Jiro Kikuchi, Yusuke Furukawa.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Abnormal endocytosis due to a Samd9L mutation causes bone marrow/multi-organ failure in mice mimicking MIRAGE syndrome.モノソミー７を伴うMDSを多発するMIRAGE症候群モデルマウスに見られた受容体取込み異常2020
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Satoru Shinriki, and Toshiya Inaba.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Regulation of receptor internalization by Samd9/Samd9L and their mutants2019
- Author(s)
  Akiko Nagamachi
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08357
[Presentation] 放射線が着床前期胚に与える影響2019
- Author(s)
  金井昭教、清水なつみ、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] モノソミー７：どこまでわかったか2019
- Author(s)
  稲葉俊哉、長町安希子
- Organizer
  日本血液学会（教育講演）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] The role of endosomal proteins, Samd9 and Samd9L, in hematopoiesis and myeloid diseases carrying monosomy 7.2019
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Satoru Shinriki, Akinori Kanai, Toshiya Inaba
- Organizer
  日本癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Regulation of receptor internalization by Samd9/Samd9L and their mutants2019
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Satoru Shinriki, Akinori Kanai, Toshiya Inaba
- Organizer
  日本血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] The role of Samd9 and Samd9L in the early endocytotic pathway2018
- Author(s)
  長町安希子
- Organizer
  第80回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08357
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井　昭教、清水　なつみ、長町　安希子、河合　秀彦、稲葉　俊哉
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Samd9/Samd9L変異体による造血障害メカニズムの解明2018
- Author(s)
  長町安希子
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井昭教、清水なつみ、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Roles of Samd9/L in MDS associated with monosomy 72018
- Author(s)
  長町安希子
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] MDS責任遺伝子Samd9/Samd9Lのエンドサイトーシス経路における機能解析2017
- Author(s)
  1.長町安希子
- Organizer
  日本血液学会総会
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] The role of Samd9 and Samd9L in the early endocytotic pathway2017
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Hiroaki Honda and Toshiya Inaba
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19575
[Presentation] The role of Samd9 and Samd9L in the early endocytotic pathway2017
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Hiroaki Honda and Toshiya Inaba
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19575
[Presentation] The role of Samd9 and Samd9L in the early endocytotic pathway.2017
- Author(s)
  Nagamachi A
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] Low Miki expression in myelodysplastic syndromes enhance the formation of polynuclear cell2016
- Author(s)
  長町安希子, 尾崎祐子、松井啓隆, 金井昭教, 稲葉俊哉
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19575
[Presentation] eEF1A2 is a target gene of DNA demethylating agents for improving anemia of MDS2016
- Author(s)
  長町安希子
- Organizer
  第75回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19575
[Presentation] Exploring haplo-insufficieny of multiple anti-oncogenes that facilitate malignant transformation2015
- Author(s)
  長町安希子、稲葉俊哉
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] Low Miki expression in myelodysplastic syndromes results in polynuclear cell formation through decondensation of chromosomes in prolonged prometaphase.2015
- Author(s)
  Nagamachi A., Ozaki Y., Matsui H., Kanai A., Inaba T.
- Organizer
  The 57th American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] 低線量率放射線照射による染色体異常出現頻度の解析2015
- Author(s)
  長町安希子, 藤岡来実, 稲葉俊哉, 神谷研二
- Organizer
  第56回原子爆弾後障害研究会
- Place of Presentation
  広島
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] eEF1A2 is a target gene of DNA demethylating agents for improving anemia of MDS2015
- Author(s)
  Nagamachi A., Matsui H., Kanai A., Inaba T.
- Organizer
  The 77th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] Exploring haplo-insufficieny of multiple anti-oncogenes that facilitate malignant transformation2015
- Author(s)
  Nagamachi A., Inaba T.
- Organizer
  The 74nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] Analysis of radiation induced mutations using next generation sequencer.2015
- Author(s)
  Kanai, A.,Nagamachi A.,Kawai H.,Matsui H.,Kamiya K., Inaba T.
- Organizer
  ICRR
- Place of Presentation
  京都
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] eEF1A2 is a target gene of DNA demethylating agents for improving anemia of MDS2015
- Author(s)
  長町安希子、松井啓隆、金井昭教、稲葉俊哉
- Organizer
  第77回日本血液学会学術総会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] Low Miki expression in myelodysplastic syndromes results in polynuclear cell formation through decondensation of chromosomes in prolonged prometaphase.2015
- Author(s)
  Nagamachi A., Ozaki Y., Matsui H., Kanai A., Inaba T.
- Organizer
  The 57th American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-06
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] 低線量率放射線照射による染色体異常出現頻度の解析2015
- Author(s)
  長町安希子, 藤岡来実, 稲葉俊哉, 神谷研二.
- Organizer
  第56回原子爆弾後障害研究会
- Place of Presentation
  広島
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] 7q欠失責任遺伝子候補Samd9Lマウスモデルの作製と機能解析2014
- Author(s)
  長町安希子
- Organizer
  第10回麒麟塾
- Place of Presentation
  コクヨホール
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] ユビキチン修飾酵素A20が造血機構に与える影響2014
- Author(s)
  長町安希子
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎原爆資料館
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] Roles of translational machinery in epigenetic therapy in MDS
- Author(s)
  長町安希子
- Organizer
  第76回日本血液学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-13 – 2014-10-15
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] モノソミー7を伴うAML/MDSのモデルマウスの作製
- Author(s)
  長町安希子
- Organizer
  「細胞運命制御」領域　若手研究者の会
- Place of Presentation
  浜名湖グランドホテル
- Year and Date
  2014-04-18 – 2014-04-19
- Data Source
  KAKENHI-PROJECT-26860735
[Presentation] Roles of translational machinery in epigenetic therapy in MDS
- Author(s)
  長町安希子
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860735

1. Kanai Akinori (60549567)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. Inaba Toshiya (60281292)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
3. 松井啓隆 (60379849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. Kamiya Kenji (60116564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 河合秀彦 (30379846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 笹谷めぐみ (80423052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 本庶仁子 (80614106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 林田耕臣 (10882061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 神代紗央理 (60882058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ZAHARIEVA ELENA (30766697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. UEDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. SHINRIKI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SANADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 坂口公祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 福嶋俊明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 本田善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 谷時雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagamachi Akiko 長町 安希子

Research Projects

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Co-Researchers

SAMD9/9LによるTGFbetaシグナルを介したHSC静止期維持システムの解明Principal Investigator

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Molecular mechanisms through which SAMD9/9L mutants cause bone marrow failure

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Functional analysis of SAMD9/9L mutations in hematopoiesis and generation of a novel humanized SAMD9/9L mouse modelPrincipal Investigator

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Analysis of Trim43 in radiation-induced arrest of fertilized egg development

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Involvement of the translation machinery in the improvement of anemia in myelodysplastic syndromes by Aza-dCPrincipal Investigator

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Abnormal endosomal traffic induced by Samd9/9L causing myelodysplastic syndromes and inherited bone marrow failure

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A novel study on the mechanisms of low-dose radiation-induced aging and carcinogenesis

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Characterizing the large chromosomal deletion in 7q- myelodysplastic syndrome using human iPS cells and the genome editing systemPrincipal Investigator

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Elucidation of molecular mechanism through which MDS develops

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Generation of mice models of AML/MDS with large genomic deletion using CRISPR/Cas9 genome editingPrincipal Investigator

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[Journal Article] Application of prime editing system to introduce P53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line2024

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[Journal Article] Ribosome profiling analysis reveals the roles of DDX41 in translational regulation2023

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[Journal Article] Mouse models of hematological diseases using genome editing technology2022

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Nagamachi Akiko 長町安希子