KUROIWA Mahomi 黒岩真帆美

Researcher Number	20585690
Other IDs
Affiliation (Current)	2021: 久留米大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2010 – 2020: 久留米大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator General pharmacology / Basic Section 52030:Psychiatry-related / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator ホスホジエステラーゼ / 統合失調症 / ドーパミン / 抗うつ薬 / 海馬歯状回 / うつ病 / DARPP-32 / 歯状回 / 大脳皮質 / 認知機能障害 … More Except Principal Investigator ドパミン / うつ病 / 抗うつ薬 / 統合失調症 / モデルマウス / 報酬系 / p11 / 海馬歯状回 / コリン作動性介在神経 / 神経回路 / マウスモデル / 脳・神経 / 薬理学 / 神経科学 / シグナル伝達 / 中脳辺縁系 / 中枢・末梢神経 / ノルアドレナリン / 海馬 / 歯状回 / 青斑核 / 治療抵抗性うつ病 / アンヘドニア Less

うつ病の薬物治療戦略：ドパミン神経系を標的とした新規治療法開発Ongoing
- Principal Investigator
  
  西昭徳
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kurume University
うつ病および統合失調症におけるドパミン・ノルアドレナリンシグナル制御機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  黒岩真帆美
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kurume University
海馬ドパミン・ノルアドレナリン入力バランス制御によるうつ病治療戦略の確立Ongoing
- Principal Investigator
  
  首藤隆秀
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kurume University
Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
- Principal Investigator
  
  Nishi Akinori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kurume University
Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disordersPrincipal Investigator
- Principal Investigator
  
  Kuroiwa Mahomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Role of PDEs in antipsychotic effects in hippocampal dentate gyrus.Principal Investigator
- Principal Investigator
  
  Kuroiwa Mahomi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Role of PDEs in antidepressant effects in the hippocampal dentate gyrus.Principal Investigator
- Principal Investigator
  
  KUROIWA Mahomi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA signaling cascade in frontal cortex.Principal Investigator
- Principal Investigator
  
  KUROIWA Mahomi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice2020
- Author(s)
  Hikida Takatoshi、Morita Makiko、Kuroiwa Mahomi、Macpherson Tom、Shuto Takahide、Sotogaku Naoki、Niwa Minae、Sawa Akira、Nishi Akinori
- Journal Title
  
  Neuroscience Research
  
  Volume: in press Pages: 38-45
- DOI
  10.1016/j.neures.2019.02.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K14579, KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-18H02542, KAKENHI-PROJECT-19H03410
[Journal Article] p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli2018
- Author(s)
  Hanada Y.、Kawahara Y.、Ohnishi Y. N.、Shuto T.、Kuroiwa M.、Sotogaku N.、Greengard P.、Sagi Y.、Nishi A.
- Journal Title
  
  eNeuro
  
  Volume: 5 Pages: 0332-18
- DOI
  10.1523/eneuro.0332-18.2018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07401, KAKENHI-PROJECT-16H05135
[Journal Article] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine2018
- Author(s)
  Shuto Takahide、Kuroiwa Mahomi、Sotogaku Naoki、Kawahara Yukie、Oh Yong-Seok、Jang Jin-Hyeok、Shin Chang-Hoon、Ohnishi Yoshinori N.、Hanada Yuuki、Miyakawa Tsuyoshi、Kim Yong、Greengard Paul、Nishi Akinori
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 10 Pages: 1-16
- DOI
  10.1038/s41380-018-0316-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07401, KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K10198
[Journal Article] Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution.2017
- Author(s)
  Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Pages: 1462-1476
- DOI
  10.1074/jbc.m116.752402
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K10198
[Journal Article] Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus2016
- Author(s)
  Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A
- Journal Title
  
  PLoS ONE
  
  Volume: 11(1)
- DOI
  10.1371/journal.pone.0147307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430078, KAKENHI-PROJECT-26860951, KAKENHI-PROJECT-26293040, KAKENHI-PROJECT-16K00934
[Journal Article] Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum2013
- Author(s)
  Takahide Shuto
- Journal Title
  
  Neurosci Lett
  
  Volume: 542 Pages: 107-112
- DOI
  10.1016/j.neulet.2013.02.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24791244
[Journal Article] Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia.2013
- Author(s)
  Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
- Journal Title
  
  Neuropsychopharmacology.
  
  Volume: 38(8) Pages: 1409-1425
- DOI
  10.1038/npp.2013.38
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-22380078, KAKENHI-PROJECT-22500342, KAKENHI-PROJECT-22651075, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23370079, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23792018, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24657008, KAKENHI-PROJECT-24791244, KAKENHI-PROJECT-25460114, KAKENHI-PLANNED-22125005
[Journal Article] Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons2012
- Author(s)
  Kuroiwa Mahomi
- Journal Title
  
  Neuropharmacology.
  
  Volume: 7 Pages: 1248-1257
- DOI
  10.1016/j.neuropharm.2012.07.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24791244
[Journal Article] Phosphodiesterase 4 inhibition enhancesthe dopamine D1 receptor/PKA/DARPP-32signaling cascade in frontal cortex.2012
- Author(s)
  Kuroiwa, M., Snyder, G. L., Shuto, T., Fukuda, A., Yanagawa, Y., Benavides, D. R., Nairn, A. C., Bibb, J. A., Greengard P. and Nishi, A.
- Journal Title
  
  Psychopharmacology(Berl).
  
  Volume: 219 Pages: 10651079-10651079
- DOI
  10.1007/s00213-011-2436-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390041, KAKENHI-PROJECT-22890228, KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24659508, KAKENHI-PUBLICLY-23115506
[Journal Article] Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons2011
- Author(s)
  Nishi A, Kuroiwa M, Shuto T.
- Journal Title
  
  Frontiers in neuroanatomy
  
  Volume: vol.5 No.43
- DOI
  10.3389/fnana.2011.00043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890228
[Journal Article] Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons2010
- Author(s)
  Hara M, Fukui R, Hieda E, Kuroiwa M, Bateup HS, Kano T, Greengard P, Nishi A.
- Journal Title
  
  Journal of neurochemistry
  
  Volume: vol.113 No.4 Pages: 1046-59
- DOI
  10.1111/j.1471-4159.2010.06668.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890228
[Presentation] 線条体における領域別ドパミンD1シグナル制御：片側パーキンソン病モデルによる影響2019
- Author(s)
  杉山　慶太、黒岩　真帆美、首藤　隆秀、福田　孝一、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A
- Organizer
  Federation of European Physiology Society (FEPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03410
[Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada H, Nishi A
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03410
[Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A
- Organizer
  FEPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptor/cAMP/PKA signaling is differently regulated in subregions of the striatum2019
- Author(s)
  Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Takaichi Fukuda and Akinori Nishi
- Organizer
  The 49th Annual meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] 抗うつ薬の作用発現における海馬歯状回ノルアドレナリン神経伝達の役割と飼育環境要因との相互作用に関する研究2019
- Author(s)
  黒岩　真帆美、楠　智華、岡山　彰洋、首藤　隆秀、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関与2019
- Author(s)
  岡山　彰洋、楠　智華、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Kawahara Y, Hanada Y, Ohnishi YN, Shuto T, Kuroiwa M, Sotogaku N, Kawahara H, Nishi A.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] Activation of dopamine D1 receptor signaling in the dentate gyrus is required for antidepressant action of SSRI in a mouse model of depression.2019
- Author(s)
  Mahomi Kuroiwa, Takahide Shuto, Naoki Sotogaku, Akinori Nishi
- Organizer
  FEPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] 海馬歯状回ドパミンD1受容体陽性細胞の選択的活性化がマウスのうつ病関連行動に及ぼす影響2019
- Author(s)
  箱田　恵子、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回　日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関与2019
- Author(s)
  岡山　彰洋、楠　智華、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回　日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Yukie Kawahara, Yuuki Hanada, Yoshinori Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Hiroshi Kawahara, Akinori Nishi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI2019
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi O, Hanada Y, Nishi A
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03410
[Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第42回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] 海馬歯状回ドパミンD1受容体陽性細胞の選択的活性化がマウスのうつ病関連行動に及ぼす影響2019
- Author(s)
  箱田　恵子、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression2018
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第48回北米神経科学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression.2018
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada Y, Nishi A.
- Organizer
  The 48th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI2018
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] 領域別線条体におけるドパミンシグナル解析2018
- Author(s)
  杦山慶太、黒岩　真帆美、首藤　隆秀、福田　孝一、西　昭徳
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression2018
- Author(s)
  T. SHUTO, M. KUROIWA, N. SOTOGAKU, Y. KAWAHARA, Y. OHNISHI, Y. HANADA, A. NISHI
- Organizer
  The 48th Annual Meeting of the Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI.2018
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada Y, Nishi A.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] 飼育環境が及ぼすストレス応答の変化2017
- Author(s)
  黒岩　真帆美、杦山　慶太、首藤　隆秀、西　昭徳
- Organizer
  第 70 回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] 飼育環境が及ぼすストレス応答の変化2017
- Author(s)
  黒岩　真帆美、杦山　慶太、首藤　隆秀、西　昭徳
- Organizer
  第70回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Glutamate counteracts dopamine/PKA signaling via dephosphorylation of DARPP-32 Ser97 and alteration of its cytonuclear distribution.2017
- Author(s)
  A Nishi, M Matamales, V Musante, E Valjent, M Kuroiwa, Y Kitahara, H Rebholz, P Greengard, J-A Girault, AC Nairn
- Organizer
  The 47th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] p11 is essential for dopamine responses to rewarding stimuli.2017
- Author(s)
  Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Nishi A
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Glutamate counteracts dopamine/PKA signaling via nuclear sequestration of inactive DARPP-322017
- Author(s)
  Mahomi Kuroiwa, Yosuke Kitahara and Akinori Nishi
- Organizer
  第９０回　日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホール　アストピア（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] 気分制御に関与する蛋白p11は報酬関連ドーパミン神経応答に必要である2016
- Author(s)
  花田　雄樹、河原　幸江、大西　克典、首藤　隆秀、黒岩　真帆美、外角　直樹、西　昭徳
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] p11, a possible mood regulator, is essential for the reward-related dopamine responses.2016
- Author(s)
  Y. HANADA, Y. KAWAHARA, Y. OHNISHI, T. SHUTO, M. KUROIWA, N. SOTOGAKU, A.NISHI
- Organizer
  The 46th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] DISC1マウスの隔離飼育に対するcAMP/PKAシグナル応答：ホスホジエステラーゼの役割2015
- Author(s)
  黒岩　真帆美、首藤　隆秀、外角　直樹、森田　真規子、澤　明、疋田　貴俊、西　昭徳
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] DISC1マウスの隔離飼育に対するドパミンシグナル応答：ホスホジエステラーゼの役割2015
- Author(s)
  黒岩　真帆美、首藤　隆秀、外角　直樹、森田　真規子、澤　明、疋田　貴俊、西　昭徳
- Organizer
  第45回日本神経精神薬理学会
- Place of Presentation
  タワーホール船堀（東京都・船堀）
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Chronic treatment with antidepressants enhances dopamine D1 receptor signaling in the hippocampal dentate gyrus2015
- Author(s)
  Kuroiwa M, Shuto T, Sotogaku N, Oh YS, Nishi A
- Organizer
  Annual Meeting of Society for Neuroscience (SFN)
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Social Isolated DISC1 Mutant Mice Displayed High Sensitivity to Chronic Cocaine Exposure and Rolipram Treatment2015
- Author(s)
  Hikida T, Morita M, Kuroiwa M, Macpherson T, Itou T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A
- Organizer
  54th American College of Neuropsychopharmacology (ACNP)
- Place of Presentation
  Hollywood (USA)
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Chronic fluoxetine treatment induces morphological changes of the perforant path synapse in the dentate gyrus: analysis of synaptic fine structures with FIB-SEM2015
- Author(s)
  Kitahara Y, Ohta K, Shuto T, Kuroiwa M, Sotogaku N, Hasuo H, Togo A, Nakamura K, Nishi A
- Organizer
  The 11th Chinese Neuroscience Society
- Place of Presentation
  Wuzhen (China)
- Year and Date
  2015-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Dopamine D1 receptor activation enhances antidepressant effects of SSRI in a mouse model of depression2015
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Nishi A
- Organizer
  Annual Meeting of Society for Neuroscience (SFN)
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] 抗うつ薬による海馬歯状回顆粒細胞の形態変化 : FIB/SEM を用いた樹状突起の3D電顕解析2014
- Author(s)
  北原陽介, 太田啓介, 首藤隆秀, 黒岩真帆美, 外角直樹, 蓮尾博, 都合亜記暢, 中村桂一郎, 西昭徳
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学百年記念会館川内萩ホール, 川内国際センター
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] ドーパミンD1受容体アゴニストとSSRIの併用投与がマウスのうつ様行動に与える影響2014
- Author(s)
  27.首藤隆秀、黒岩真帆美、外角直樹、西昭徳
- Organizer
  第67回日本薬理学会西南部会
- Place of Presentation
  産業医科大学（福岡・北九州）
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] 抗うつ薬による海馬歯状回顆粒細胞の形態変化：FIB/SEMを用いた樹状突起の3D電顕解析2014
- Author(s)
  北原陽介、太田啓介、首藤隆秀、黒岩真帆美、外角直樹、蓮尾博、都合亜記暢、中村桂一郎、西昭徳
- Organizer
  薬理学会年会
- Place of Presentation
  東北大学百周年記念会館川内萩ホール、仙台国際センター
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] 線条体におけるムスカリン受容体を介したDARPP-32 リン酸化調節2013
- Author(s)
  黒岩真帆美, 浜田美保, 稗田恵理子, 首藤隆秀, 外角直樹, 西昭徳
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] 線条体におけるムスカリン受容体を介したDARPP-32リン酸化調節2013
- Author(s)
  黒岩　真帆美、浜田　美保、稗田　恵理子、首藤　隆秀、外角　直樹、西　昭徳
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] コカインで増強される線条体ドーパミン情報伝達に対するレスベラトロールの急性薬理作用2013
- Author(s)
  首藤隆秀, 黒岩真帆美, 古賀夕貴, 河原幸江, 外角直樹, 西昭徳
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用2012
- Author(s)
  首藤隆秀, 黒岩真帆美, 古賀夕貴, 西昭徳
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本大学薬学部
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] ムスカリン受容体による線条体ドーパミン情報伝達系の調節2011
- Author(s)
  黒岩真帆美
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-22890228
[Presentation] Effect of fluoxetine in dopamine D1 receptor signaling in the hippocampal dentate gyrus2011
- Author(s)
  黒岩真帆美
- Organizer
  第41回神経精神薬理学会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22890228
[Presentation] 大脳皮質ドーパミンD1シグナルを制御するホスホジエステラーゼ4に関する研究2010
- Author(s)
  黒岩真帆美
- Organizer
  第40回日本神経精神薬理学会年会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-22890228
[Presentation] Regulation of DARPP-32 phosphorylation by muscarinic receptors via presynaptic and postsynaptic mechanisms in the striatum2010
- Author(s)
  黒岩真帆美
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  鹿児島県民交流センター(鹿児島県)
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22890228
[Presentation] 抗うつ薬の慢性投与は海馬歯状回ドーパミンD1受容体シグナルを増強する
- Author(s)
  黒岩　真帆美、首藤　隆秀、外角　直樹、西　昭徳
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Social isolated DISC1 mutant mice displayed high sensitivity to chronic cocaine exposure and rolipram treatment.
- Author(s)
  25.Hikida T, Morita M, Niwa M, Kuroiwa M, Hanna Jaaro-Peled, Sawa A, Nishi A
- Organizer
  Annual Meeting of Society for Neuroscience (SfN)
- Place of Presentation
  ワシントンDC（アメリカ）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Role of PDE-mediated signaling and its crosstalk in brain function.
- Author(s)
  Nishi A, Kuroiwa M, Shuto S, Snyder GL
- Organizer
  CINP2014
- Place of Presentation
  バンクーバー（カナダ）
- Year and Date
  2014-06-22 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Altered regulation of cAMP/PKA signaling by PDE10A and PDE4 in DISC1 mutant mice.
- Author(s)
  24.Nishi A, Kuroiwa M, Shuto T, Sotogaku N, Morita M, Sawa A, Hikida T
- Organizer
  Annual Meeting of Society for Neuroscience (SfN)
- Place of Presentation
  ワシントンDC（アメリカ）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用
- Author(s)
  首藤　隆秀、黒岩　真帆美、古賀　夕貴、西　昭徳
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本大学薬学部
- Data Source
  KAKENHI-PROJECT-24791244
[Presentation] ドーパミンD1受容体アゴニスト併用投与によるSSRIのマウスうつ様行動に対する治療効果の増強
- Author(s)
  首藤　隆秀、黒岩　真帆美、外角　直樹、西　昭徳
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Chronic fluoxetine induces the enlargement of perforant path synapse in the dentate gyrus: 3D ultrastructural analyses using FIB/SEM.
- Author(s)
  26.Kitahara Y, Ohta K, Shuto T, Kuroiwa M, Sotogaku N, Hasuo H, Togo A, Nakamura K, Nishi A.
- Organizer
  Annual Meeting of Society for Neuroscience (SfN)
- Place of Presentation
  ワシントンDC（アメリカ）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26860951
[Presentation] Effect of chronic fluoxetine on the morphology of perforant path synapse in the dentate gyrus: 3D ultrastructural analyses using FIB/SEM.
- Author(s)
  19.北原陽介、太田啓介、首藤隆秀、黒岩真帆美、外角直樹、蓮尾博、都合亜記暢、中村桂一郎、西昭徳
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26860951

1. Nishi Akinori (50228144)

# of Collaborated Projects: 5 results

# of Collaborated Products: 35 results
2. 首藤隆秀 (70412541)

# of Collaborated Projects: 5 results

# of Collaborated Products: 35 results
3. 大西克典 (10626865)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
4. 外角直樹 (60368884)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
5. 河原幸江 (10279135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. Greengard Paul

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Segi Yotam

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Kim Yong

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Bibb James A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Oh Yong-Seok

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. Hikida Takatoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TAKAO Keizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. UMEMORI Juzoh

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. ATSUZAWA Kimie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. MACPHERSON Tom

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. MORITA Makiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 大西陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 太田啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 都合亜記暢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 中村桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 福田敦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 鈴木匡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 鈴木道雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 小林和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 宮川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 森寿

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 高尾英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 中村克樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 古屋茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 小林克典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 須原哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 前田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 石井俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUROIWA Mahomi 黒岩 真帆美

Research Projects

Research Products

Co-Researchers

うつ病の薬物治療戦略：ドパミン神経系を標的とした新規治療法開発Ongoing

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うつ病および統合失調症におけるドパミン・ノルアドレナリンシグナル制御機構の解明Principal InvestigatorOngoing

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海馬ドパミン・ノルアドレナリン入力バランス制御によるうつ病治療戦略の確立Ongoing

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Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders

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Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disordersPrincipal Investigator

Principal Investigator

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Role of PDEs in antipsychotic effects in hippocampal dentate gyrus.Principal Investigator

Principal Investigator

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Role of PDEs in antidepressant effects in the hippocampal dentate gyrus.Principal Investigator

Principal Investigator

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Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA signaling cascade in frontal cortex.Principal Investigator

Principal Investigator

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[Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice2020

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[Journal Article] p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli2018

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DOI

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[Journal Article] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine2018

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DOI

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[Journal Article] Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution.2017

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DOI

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[Journal Article] Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus2016

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[Journal Article] Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum2013

Author(s)

Journal Title

KUROIWA Mahomi 黒岩真帆美

[Presentation] 抗うつ薬の作用発現における海馬歯状回ノルアドレナリン神経伝達の役割と飼育環境要因との相互作用に関する研究2019

[Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関与2019