Shuto Takahide 首藤隆秀

… Alternative Names

Researcher Number	70412541
Other IDs
Affiliation (Current)	2021: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2020: 久留米大学, 医学部, 講師 2014: 久留米大学, 医学部, 助教 2009 – 2012: Kurume University, 医学部, 助教 2007: Kurume University, Sch of Med, Dept of Pharmacology, Research Associate 2006: 久留米大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Psychiatric science / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / General pharmacology / Anesthesiology / Basic Section 48030:Pharmacology-related / Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator 薬物依存 / ドーパミン / メタンフェタミン / 精神薬理学 / 逆耐性 / DARPP-32 / 線条体 / 薬物依存、 / 統合失調症、 / ドーパミン、 … More Except Principal Investigator 統合失調症 / うつ病 / ドパミン / ドーパミン / DARPP-32 / 海馬歯状回 / 脳・神経 / 薬理学 / 抗うつ薬 / コンドロイチン硫酸 / 糖鎖分子 / 細胞外マトリックス / 神経細胞 / 神経細胞死 / 糖鎖 / 細胞接着 / 線条体 / リン酸化 / 細胞内情報伝達 / dopamine / neostriatum / phosphorylation / signal transduction / モデルマウス / 報酬系 / p11 / コリン作動性介在神経 / 神経回路 / マウスモデル / 神経科学 / シグナル伝達 / 中脳辺縁系 / 中枢・末梢神経 / コカイン / S1Pレセプター / FTY720 / ドーパミンD1シグナル / フィンゴリモド塩酸塩（FTY720) / スフィンゴシン-1-リン酸 / スフィンゴシン-1-リン酸受容体 / 薬物乱用・薬物依存 / フィンゴリモド塩酸塩 / ドーパミンＤ１シグナル / ホスホジエステラーゼ / 脳神経疾患 / 敗血症 / 敗血症関連脳症 / メラトニン / トリプトファン / キヌレニン経路 / セロトニン経路 / サイトカイン / テトラヒドロビオプテリン / 盲腸結紮穿孔モデル / 酸化ストレス応答 / 治療抵抗性うつ病 / アンヘドニア / ノルアドレナリン / 海馬 / 歯状回 / D1受容体 Less

うつ病の薬物治療戦略：ドパミン神経系を標的とした新規治療法開発Ongoing
- Principal Investigator
  
  西昭徳
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kurume University
うつ病および統合失調症におけるドパミン・ノルアドレナリンシグナル制御機構の解明Ongoing
- Principal Investigator
  
  黒岩真帆美
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kurume University
海馬ドパミン・ノルアドレナリン入力バランス制御によるうつ病治療戦略の確立Principal InvestigatorOngoing
- Principal Investigator
  
  首藤隆秀
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kurume University
Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathy
- Principal Investigator
  
  Niiyama Shuhei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Kagoshima University
  Kurume University
Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
- Principal Investigator
  
  Nishi Akinori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kurume University
Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal
- Principal Investigator
  
  Uematsu Ken
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
- Principal Investigator
  
  Kuroiwa Mahomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Role of chondroitin sulfate-E in the modulation of neuronal morphology
- Principal Investigator
  
  Sotogaku Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kurume University
Dopamine D1 receptor agonists may be useful therapeutic agents for the treatment of drug addiction and schizophrenia.Principal Investigator
- Principal Investigator
  
  SHUTO Takahide
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Development of treatment for drug addiction : Reversal of sensitization by dopamine D1 receptor signalingPrincipal Investigator
- Principal Investigator
  
  SHUTO Takahide
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions
- Principal Investigator
  
  NISHI Akinori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kurume University

All 2020 2019 2018 2017 2016 2013 2012 2011 2008 2007 2006

All Journal Article Presentation

[Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice2020
- Author(s)
  Hikida Takatoshi、Morita Makiko、Kuroiwa Mahomi、Macpherson Tom、Shuto Takahide、Sotogaku Naoki、Niwa Minae、Sawa Akira、Nishi Akinori
- Journal Title
  
  Neuroscience Research
  
  Volume: in press Pages: 38-45
- DOI
  10.1016/j.neures.2019.02.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K14579, KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-18H02542, KAKENHI-PROJECT-19H03410
[Journal Article] p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli2018
- Author(s)
  Hanada Y.、Kawahara Y.、Ohnishi Y. N.、Shuto T.、Kuroiwa M.、Sotogaku N.、Greengard P.、Sagi Y.、Nishi A.
- Journal Title
  
  eNeuro
  
  Volume: 5 Pages: 0332-18
- DOI
  10.1523/eneuro.0332-18.2018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07401, KAKENHI-PROJECT-16H05135
[Journal Article] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine2018
- Author(s)
  Shuto Takahide、Kuroiwa Mahomi、Sotogaku Naoki、Kawahara Yukie、Oh Yong-Seok、Jang Jin-Hyeok、Shin Chang-Hoon、Ohnishi Yoshinori N.、Hanada Yuuki、Miyakawa Tsuyoshi、Kim Yong、Greengard Paul、Nishi Akinori
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 10 Pages: 1-16
- DOI
  10.1038/s41380-018-0316-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07401, KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K10198
[Journal Article] Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders2016
- Author(s)
  Nishi A, Shuto T
- Journal Title
  
  Expert Opin Ther Targets
  
  Volume: 21 Pages: 259-272
- DOI
  10.1080/14728222.2017.1279149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05135
[Journal Article] Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus2016
- Author(s)
  Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A
- Journal Title
  
  PLoS ONE
  
  Volume: 11(1)
- DOI
  10.1371/journal.pone.0147307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430078, KAKENHI-PROJECT-26860951, KAKENHI-PROJECT-26293040, KAKENHI-PROJECT-16K00934
[Journal Article] Chronic fluoxetine induces the enlargment of perforant path-granule cell synapses in the mouse dentate gyrus.2016
- Author(s)
  Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A
- Journal Title
  
  PLoS One
  
  Volume: 11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430078
[Journal Article] Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum2013
- Author(s)
  Takahide Shuto
- Journal Title
  
  Neurosci Lett
  
  Volume: 542 Pages: 107-112
- DOI
  10.1016/j.neulet.2013.02.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24791244
[Journal Article] Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons2012
- Author(s)
  Kuroiwa Mahomi
- Journal Title
  
  Neuropharmacology.
  
  Volume: 7 Pages: 1248-1257
- DOI
  10.1016/j.neuropharm.2012.07.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24791244
[Journal Article] Phosphodiesterase 4 inhibition enhancesthe dopamine D1 receptor/PKA/DARPP-32signaling cascade in frontal cortex.2012
- Author(s)
  Kuroiwa, M., Snyder, G. L., Shuto, T., Fukuda, A., Yanagawa, Y., Benavides, D. R., Nairn, A. C., Bibb, J. A., Greengard P. and Nishi, A.
- Journal Title
  
  Psychopharmacology(Berl).
  
  Volume: 219 Pages: 10651079-10651079
- DOI
  10.1007/s00213-011-2436-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390041, KAKENHI-PROJECT-22890228, KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24659508, KAKENHI-PUBLICLY-23115506
[Journal Article] Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia.2011
- Author(s)
  Takahide Shuto
- Journal Title
  
  CNS Neurosci Ther.
  
  Volume: 17 Pages: 133-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791154
[Journal Article] Treatment of the psychostimulant-sensitized animal model of schizophrenia.2011
- Author(s)
  Shuto T, Nishi A.
- Journal Title
  
  CNS Neurosci Ther. 17
  
  Pages: 133-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791154
[Journal Article] Treatmentof thepsychostimulant-sensitized animal modelof schizophrenia.2011
- Author(s)
  ShutoT,NishiA.
- Journal Title
  
  CNS Neurosci Ther.
  
  Volume: 17 Pages: 133-139
- DOI
  10.1111/j.1755-5949.2010.00218.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791359
[Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats2008
- Author(s)
  Shuto T
- Journal Title
  
  Eur J Neurosci
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300128
[Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1 High and D2High receptors in methamhetamine-sensitized rats2008
- Author(s)
  Shuto T
- Journal Title
  
  Eur J Neurosci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300128
[Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1^<High> and D2^<High> receptors in methamphetamine-sensitized rats.2008
- Author(s)
  Shuto T, Seeman P, Kuroiwa M, Nishi A.
- Journal Title
  
  Eur J Neurosci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Journal Article] Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.2007
- Author(s)
  Kitaoka S, Furuyashiki T, Nishi A, Shuto T, Koyasu S, Matsuoka T, Miyasaka M, Greengard P, Narumiya S.
- Journal Title
  
  J Neurosci 27
  
  Pages: 12900-12907
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Journal Article] Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist2006
- Author(s)
  Shuto T
- Journal Title
  
  Neuropharmacology 50
  
  Pages: 991-997
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300128
[Journal Article] Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist.2006
- Author(s)
  Shuto T, Kuroiwa M, Hamamura M, Yabuuchi K, Shimazoe T, Watanabe S, Nishi A, Yamamoto T.
- Journal Title
  
  Neuropharmacology 50
  
  Pages: 991-997
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Journal Article] Role of adenosine Al receptors in the modulation of dopamine DI and adenosine A_<2A> receptor signaling in the neostriatum.2006
- Author(s)
  Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A.
- Journal Title
  
  Neuroscience 141
  
  Pages: 19-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] 線条体における領域別ドパミンD1シグナル制御：片側パーキンソン病モデルによる影響2019
- Author(s)
  杉山　慶太、黒岩　真帆美、首藤　隆秀、福田　孝一、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A
- Organizer
  Federation of European Physiology Society (FEPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03410
[Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada H, Nishi A
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03410
[Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A
- Organizer
  FEPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptor/cAMP/PKA signaling is differently regulated in subregions of the striatum2019
- Author(s)
  Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Takaichi Fukuda and Akinori Nishi
- Organizer
  The 49th Annual meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] 抗うつ薬の作用発現における海馬歯状回ノルアドレナリン神経伝達の役割と飼育環境要因との相互作用に関する研究2019
- Author(s)
  黒岩　真帆美、楠　智華、岡山　彰洋、首藤　隆秀、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関与2019
- Author(s)
  岡山　彰洋、楠　智華、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Kawahara Y, Hanada Y, Ohnishi YN, Shuto T, Kuroiwa M, Sotogaku N, Kawahara H, Nishi A.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] Activation of dopamine D1 receptor signaling in the dentate gyrus is required for antidepressant action of SSRI in a mouse model of depression.2019
- Author(s)
  Mahomi Kuroiwa, Takahide Shuto, Naoki Sotogaku, Akinori Nishi
- Organizer
  FEPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] 海馬歯状回ドパミンD1受容体陽性細胞の選択的活性化がマウスのうつ病関連行動に及ぼす影響2019
- Author(s)
  箱田　恵子、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回　日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関与2019
- Author(s)
  岡山　彰洋、楠　智華、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回　日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019
- Author(s)
  Yukie Kawahara, Yuuki Hanada, Yoshinori Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Hiroshi Kawahara, Akinori Nishi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI2019
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi O, Hanada Y, Nishi A
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03410
[Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第42回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] 海馬歯状回ドパミンD1受容体陽性細胞の選択的活性化がマウスのうつ病関連行動に及ぼす影響2019
- Author(s)
  箱田　恵子、首藤　隆秀、黒岩　真帆美、西　昭徳
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K08083
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression2018
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第48回北米神経科学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression.2018
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada Y, Nishi A.
- Organizer
  The 48th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI2018
- Author(s)
  Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] 領域別線条体におけるドパミンシグナル解析2018
- Author(s)
  杦山慶太、黒岩　真帆美、首藤　隆秀、福田　孝一、西　昭徳
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression2018
- Author(s)
  T. SHUTO, M. KUROIWA, N. SOTOGAKU, Y. KAWAHARA, Y. OHNISHI, Y. HANADA, A. NISHI
- Organizer
  The 48th Annual Meeting of the Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07614
[Presentation] Fingolimod (FTY720) suppress cocaine-induced hyper locomotion, which attenuate striatal D1-type medium spiny neurons of PKA/DARPP-32 signaling.2018
- Author(s)
  Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
- Organizer
  Society for Neuroscience
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI.2018
- Author(s)
  Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada Y, Nishi A.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Role of dopamine D1 receptors in antidepressant action of SSRI2018
- Author(s)
  Shuto T, Kawahara Y, Nishi A.
- Organizer
  第45回日本脳科学会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] 飼育環境が及ぼすストレス応答の変化2017
- Author(s)
  黒岩　真帆美、杦山　慶太、首藤　隆秀、西　昭徳
- Organizer
  第 70 回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16K10198
[Presentation] Fingolimod attenuates cocaine-induced locomotor activities in vivo by decreasing PKA/DARPP-32 signaling in striatal D1-type medium spiny neurons.（フィンゴリモドは線条体のドーパミンD1タイプ線条体中型有棘神経細胞でPKA/DARPP-32シグナルを抑制してコカインによる過活動性を減弱させる）2017
- Author(s)
  上松　謙、首藤　隆秀、小路　純央、内村　直尚、西　昭徳
- Organizer
  第９０回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] Fingolomod attenuate cocaine induced locomotor activity by decreasing PKA/DARPP32 signaling in striatal D1-type medium spiny neurons.2017
- Author(s)
  Ken Uematsu, Takahide Shuto, Naohisa Uchimura, Akinori Nishi
- Organizer
  Neuro Science 2017 ( Washington, DC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] 飼育環境が及ぼすストレス応答の変化2017
- Author(s)
  黒岩　真帆美、杦山　慶太、首藤　隆秀、西　昭徳
- Organizer
  第70回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] p11 is essential for dopamine responses to rewarding stimuli.2017
- Author(s)
  Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Nishi A
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Sphingosine-1-phosphate (S1P) and fingolimod regulate PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms.2016
- Author(s)
  Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
- Organizer
  Neuro Science 2016
- Place of Presentation
  Sandiego convention center
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] p11, a possible mood regulator, is essential for the reward-related dopamine responses.2016
- Author(s)
  Y. HANADA, Y. KAWAHARA, Y. OHNISHI, T. SHUTO, M. KUROIWA, N. SOTOGAKU, A.NISHI
- Organizer
  The 46th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] Fingolomod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms （フィンゴリモドはスフィンゴシン－１－リン酸受容体を介して線条体中型有棘細胞のPKA/DARPP-32シグナル伝達を制御する）2016
- Author(s)
  上松　謙、花田　雄樹、首藤　隆秀、小路　純央、内村　直尚、西　昭徳
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] ドーパミンシグナルを制御するDARPP-32：神経タイプ特異的な機能と制御2016
- Author(s)
  西　昭徳、首藤隆秀
- Organizer
  日本神経精神薬理学会
- Place of Presentation
  ソウル
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-16H05135
[Presentation] コカインで増強される線条体ドーパミン情報伝達に対するレスベラトロールの急性薬理作用2013
- Author(s)
  首藤　隆秀
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] コカインで増強される線条体ドーパミン情報伝達に対するレスベラトロールの急性薬理作用2013
- Author(s)
  首藤隆秀、黒岩真帆美、古賀夕貴、河原幸江、外角直樹、西昭徳
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] 線条体におけるムスカリン受容体を介したDARPP-32リン酸化調節2013
- Author(s)
  黒岩真帆美、浜田美保、稗田恵理子、首藤隆秀、外角直樹、西昭徳
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用2012
- Author(s)
  首藤隆秀、黒岩真帆美、古賀夕貴、西昭徳
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] コカインにより活性化される線条体ドーパミンD1受容体シグナルに対するレスベラトロールの影響2012
- Author(s)
  首藤隆秀、黒岩真帆美、古賀夕貴、西昭徳
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] コカインにより活性化される線条体ドーパミンD1受容体シグナルに対するレスベラトロールの影響2012
- Author(s)
  首藤　隆秀
- Organizer
  第85回　日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用2012
- Author(s)
  首藤　隆秀
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本大学薬学部（熊本）
- Data Source
  KAKENHI-PROJECT-23791359
[Presentation] sirtuin を活性化するresveratrol のコカイン逆耐性現象に対する影響2011
- Author(s)
  古賀夕貴, 首藤隆秀, 黒岩真帆美, 豊増功次, 西昭徳
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-21791154
[Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine D1 receptor agonism:Effect on the affinity of dopamine D1 and D2 receptor2008
- Author(s)
  Shuto T
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine DI receptor agonism : Effect on the affinity of dopamine Dl and D2 receptor.2008
- Author(s)
  Shuto T, Seeman P, Nishi A.
- Organizer
  The 59th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine D1 receptor agonism:Effect on the affmity of dopamine D1 and D2 receptor2008
- Author(s)
  Shuto T
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice.2007
- Author(s)
  Shuto T, Nishi A.
- Organizer
  The 59th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Reversal of methamphetamine sensitization by chronic dopamine DI agonist administration : affinities and binding-sites of dopamine receptors in the striatum2007
- Author(s)
  Shuto T, Nishi A.
- Organizer
  The 34th Annual Meeting of The Japan Brain Science Society
- Place of Presentation
  Izumo
- Year and Date
  2007-06-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] メタンフェタミン逆耐性を消失させるドーパミンD1受容体刺激薬反復投与:線条体ドーパミン受容体親和性への影響2007
- Author(s)
  首藤隆秀
- Organizer
  第60回日本薬理学会西南部会
- Place of Presentation
  宮崎
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Repeated administration of dopamine D1 receptor agonist reverses the increased proportion of high-affinity dopamine D1 and D2 receptors in methamphetamine-sensitized rats2007
- Author(s)
  Shuto T
- Organizer
  The 37th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego,USA
- Year and Date
  2007-11-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Repeated administration of dopamine Dl receptor agonist reverses the increased proportion of high-affinity dopamine Dl and D2 receptors in methamphetamine-sensitized rats.2007
- Author(s)
  Shuto T, Kuroiwa M, Seeman P, Nishi A
- Organizer
  The 37th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego in USA
- Year and Date
  2007-11-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Reversal of methamphetamine sensitization by chronic dopamine Dl agonist administration : effect on dopamine receptor affinities in the striatum2007
- Author(s)
  Shuto T, Nishi A.
- Organizer
  The 60th Annual Meeting of The Japanese Pharmacological Society in Seinan-Bukai
- Place of Presentation
  Miyazaki
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice2007
- Author(s)
  Shuto T
- Organizer
  第80回日本薬理学会年会
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Repeated administration of dopamine D1 receptor agonist reverses the increased proportion of high-affinity dopamine D1 and D2 receptors in methamphetamine-sensitized rats.2007
- Author(s)
  Shuto T
- Organizer
  The 37th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego,USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] メタンフェタミン逆耐性を消失させるドーパミンD1受容体刺激薬反復投与:線条体ドーパミン受容体親和性および発現数への影響2007
- Author(s)
  首藤隆秀
- Organizer
  第34回日本脳科学会
- Place of Presentation
  出雲
- Year and Date
  2007-06-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] メタンフェタミン逆耐性を消失させるドーパミンDl受容体刺激薬反復投与:線条体ドーパミン受容体親和性および発現数への影響2007
- Author(s)
  首藤隆秀
- Organizer
  第34回日本脳科学会
- Place of Presentation
  出雲
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] メタンフェタミン逆耐性におけるDARPP-32 in vivoリン酸化の評価2006
- Author(s)
  首藤隆秀
- Organizer
  第8回ブレインサイエンス研究会
- Place of Presentation
  北九州
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300128
[Presentation] Analysis of DARPP-32 phosphorylation in vivo in methamphetamine-sensitized rats.2006
- Author(s)
  Shuto T, Nishi A.
- Organizer
  The 8th Annual Meeting of The Brain Science Kenkyukai
- Place of Presentation
  Kitakyusyu
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300128

1. NISHI Akinori (50228144)

# of Collaborated Projects: 8 results

# of Collaborated Products: 51 results
2. Sotogaku Naoki (60368884)

# of Collaborated Projects: 6 results

# of Collaborated Products: 17 results
3. Kuroiwa Mahomi (20585690)

# of Collaborated Projects: 5 results

# of Collaborated Products: 35 results
4. 大西克典 (10626865)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
5. KAWAHARA Yukie (10279135)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
6. SHIMAMURA Kenji (70301140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HATAKEYAMA Jun (90404350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Uematsu Ken (60441672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. Niiyama Shuhei (40258455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 渡邉優香 (80412542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高須修 (90236216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Greengard Paul

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. Segi Yotam

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Kim Yong

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Bibb James A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Oh Yong-Seok

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. Hikida Takatoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. MACPHERSON Tom

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. MORITA Makiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 大西陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 太田啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 都合亜記暢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 中村桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 渡邉優香(江副優香)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 福田敦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shuto Takahide 首藤 隆秀

首藤 隆秀 シユトウ タカヒデ

SHUTO Takahide 首藤 隆秀

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うつ病の薬物治療戦略：ドパミン神経系を標的とした新規治療法開発Ongoing

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うつ病および統合失調症におけるドパミン・ノルアドレナリンシグナル制御機構の解明Ongoing

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海馬ドパミン・ノルアドレナリン入力バランス制御によるうつ病治療戦略の確立Principal InvestigatorOngoing

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Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathy

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Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders

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Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal

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Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders

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Role of chondroitin sulfate-E in the modulation of neuronal morphology

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Dopamine D1 receptor agonists may be useful therapeutic agents for the treatment of drug addiction and schizophrenia.Principal Investigator

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Development of treatment for drug addiction : Reversal of sensitization by dopamine D1 receptor signalingPrincipal Investigator

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Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions

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[Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice2020

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DOI

Data Source

[Journal Article] p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli2018

Author(s)

Journal Title

Shuto Takahide 首藤隆秀

首藤隆秀シユトウタカヒデ

SHUTO Takahide 首藤隆秀