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Shuto Takahide  首藤 隆秀

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SHUTO Takahide  首藤 隆秀

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Researcher Number 70412541
Other IDs
Affiliation (Current) 2022: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2022: 久留米大学, 医学部, 准教授
2015 – 2021: 久留米大学, 医学部, 講師
2014: 久留米大学, 医学部, 助教
2009 – 2012: Kurume University, 医学部, 助教
2007: Kurume University, Sch of Med, Dept of Pharmacology, Research Associate
2006: 久留米大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Psychiatric science / Basic Section 52030:Psychiatry-related
Except Principal Investigator
Psychiatric science / Basic Section 52030:Psychiatry-related / Basic Section 48030:Pharmacology-related / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / General pharmacology / Anesthesiology
Keywords
Principal Investigator
薬物依存 / ドーパミン / メタンフェタミン / 精神薬理学 / 逆耐性 / DARPP-32 / 線条体 / 薬物依存、 / 統合失調症、 / ドーパミン、 … More / 、コカイン / 統合失調症 / コカイン / うつ病 / ドパミン / 海馬 / 歯状回 / 抗うつ薬 / ノルアドレナリン / 青斑核 … More
Except Principal Investigator
ドパミン / うつ病 / 統合失調症 / ドーパミン / DARPP-32 / p11 / 海馬歯状回 / 脳・神経 / 薬理学 / 抗うつ薬 / コンドロイチン硫酸 / 糖鎖分子 / 細胞外マトリックス / 神経細胞 / 神経細胞死 / 糖鎖 / 細胞接着 / 線条体 / リン酸化 / 細胞内情報伝達 / dopamine / neostriatum / phosphorylation / signal transduction / モデルマウス / 報酬系 / コリン作動性介在神経 / 神経回路 / マウスモデル / 神経科学 / シグナル伝達 / 中脳辺縁系 / 中枢・末梢神経 / コカイン / S1Pレセプター / FTY720 / ドーパミンD1シグナル / フィンゴリモド塩酸塩(FTY720) / スフィンゴシン-1-リン酸 / スフィンゴシン-1-リン酸受容体 / 薬物乱用・薬物依存 / フィンゴリモド塩酸塩 / ドーパミンD1シグナル / ホスホジエステラーゼ / 脳神経疾患 / 敗血症 / 敗血症関連脳症 / メラトニン / トリプトファン / キヌレニン経路 / セロトニン経路 / サイトカイン / テトラヒドロビオプテリン / 盲腸結紮穿孔モデル / 酸化ストレス応答 / ノルアドレナリン / 海馬 / 歯状回 / D1受容体 / 治療抵抗性うつ病 / アンヘドニア / コリン作動性神経 / 神経精神疾患 / 薬物療法 / 炎症性シグナル Less
  • Research Projects

    (13 results)
  • Research Products

    (82 results)
  • Co-Researchers

    (25 People)
  •  Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling

    • Principal Investigator
      西 昭徳
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Kurume University
  •  炎症性疾患によるうつ病発症機序の解明:脳内ドパミンシグナルに着目して

    • Principal Investigator
      黒岩 真帆美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Kurume University
  •  うつ病および統合失調症におけるドパミン・ノルアドレナリンシグナル制御機構の解明

    • Principal Investigator
      黒岩 真帆美
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Kurume University
  •  うつ病の薬物治療戦略:ドパミン神経系を標的とした新規治療法開発

    • Principal Investigator
      西 昭徳
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Kurume University
  •  Investigation of the interaction between dopamine and noradrenaline signaling in the hippocampus to develop novel treatment of depressionPrincipal Investigator

    • Principal Investigator
      Shuto Takahide
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Kurume University
  •  Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathy

    • Principal Investigator
      Niiyama Shuhei
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Kagoshima University
      Kurume University
  •  Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders

    • Principal Investigator
      Nishi Akinori
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Kurume University
  •  Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal

    • Principal Investigator
      Uematsu Ken
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University
  •  Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders

    • Principal Investigator
      Kuroiwa Mahomi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University
  •  Role of chondroitin sulfate-E in the modulation of neuronal morphology

    • Principal Investigator
      Sotogaku Naoki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume University
  •  Dopamine D1 receptor agonists may be useful therapeutic agents for the treatment of drug addiction and schizophrenia.Principal Investigator

    • Principal Investigator
      SHUTO Takahide
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University
  •  Development of treatment for drug addiction : Reversal of sensitization by dopamine D1 receptor signalingPrincipal Investigator

    • Principal Investigator
      SHUTO Takahide
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University
  •  Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions

    • Principal Investigator
      NISHI Akinori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume University

All 2020 2019 2018 2017 2016 2013 2012 2011 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.2020

    • Author(s)
      Shuto Takahide、Kuroiwa Mahomi、Sotogaku Naoki、Kawahara Yukie、Oh Yong-Seok、Jang Jin-Hyeok、Shin Chang-Hoon、Ohnishi Yoshinori N.、Hanada Yuuki、Miyakawa Tsuyoshi、Kim Yong、Greengard Paul、Nishi Akinori
    • Journal Title

      Mol Psychiatry

      Volume: 10 Pages: 1229-1244

    • DOI

      10.1038/s41380-018-0316-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07401, KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K10198, KAKENHI-PROJECT-19H03410
  • [Journal Article] Sex Differences in Dendritic Spine Formation in the Hippocampus and Animal Behaviors in a Mouse Model of Hyperthyroidism.2020

    • Author(s)
      Niiyama Tetsushi、Kuroiwa Mahomi、Yoshioka Yusaku、Kitahara Yosuke、Shuto Takahide、Kakuma Tatsuyuki、Ohta Keisuke、Nakamura Kei-ichiro、Nishi Akinori、Noda Mami
    • Journal Title

      Front Cell Neurosci

      Volume: 14 Pages: 268-268

    • DOI

      10.3389/fncel.2020.00268

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08083, KAKENHI-PROJECT-19K11733, KAKENHI-PROJECT-19H03410
  • [Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice2020

    • Author(s)
      Hikida Takatoshi、Morita Makiko、Kuroiwa Mahomi、Macpherson Tom、Shuto Takahide、Sotogaku Naoki、Niwa Minae、Sawa Akira、Nishi Akinori
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 38-45

    • DOI

      10.1016/j.neures.2019.02.007

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05135, KAKENHI-PROJECT-16K14579, KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-18H02542, KAKENHI-PROJECT-19H03410
  • [Journal Article] p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli2018

    • Author(s)
      Hanada Y.、Kawahara Y.、Ohnishi Y. N.、Shuto T.、Kuroiwa M.、Sotogaku N.、Greengard P.、Sagi Y.、Nishi A.
    • Journal Title

      eNeuro

      Volume: 5 Pages: 0332-18

    • DOI

      10.1523/eneuro.0332-18.2018

    • NAID

      130007812630

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07401, KAKENHI-PROJECT-16H05135
  • [Journal Article] Chronic fluoxetine induces the enlargement of perforant path-granule cell synapses in the mouse dentate gyrus2016

    • Author(s)
      Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A
    • Journal Title

      PLoS ONE

      Volume: 11(1)

    • DOI

      10.1371/journal.pone.0147307

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26430078, KAKENHI-PROJECT-26860951, KAKENHI-PROJECT-26293040, KAKENHI-PROJECT-16K00934
  • [Journal Article] Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders2016

    • Author(s)
      Nishi A, Shuto T
    • Journal Title

      Expert Opin Ther Targets

      Volume: 21 Pages: 259-272

    • DOI

      10.1080/14728222.2017.1279149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Journal Article] Chronic fluoxetine induces the enlargment of perforant path-granule cell synapses in the mouse dentate gyrus.2016

    • Author(s)
      Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A
    • Journal Title

      PLoS One

      Volume: 11

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26430078
  • [Journal Article] Acute effects of resveratrol to enhancecocaine-induced dopamineneurotransmissionin the striatum.2013

    • Author(s)
      Takahide Shuto
    • Journal Title

      Neurosci Lett

      Volume: 542 Pages: 107-112

    • DOI

      10.1016/j.neulet.2013.02.050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24791244
  • [Journal Article] Muscarinic receptors acting at pre- andpost-synaptic sites differentiallyregulate dopamine/DARPP-32 signaling instriatonigral and striatopallidalneurons.2012

    • Author(s)
      Kuroiwa Mahomi
    • Journal Title

      Neuropharmacology.

      Volume: 7 Pages: 1248-1257

    • DOI

      10.1016/j.neuropharm.2012.07.046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24791244
  • [Journal Article] Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex2012

    • Author(s)
      Kuroiwa, M., Snyder, G. L., Shuto, T., Fukuda, A., Yanagawa, Y., Benavides, D. R., Nairn, A. C., Bibb, J. A., Greengard P. and Nishi, A.
    • Journal Title

      Psychopharmacology(Berl).

      Volume: 219 Pages: 10651079-10651079

    • DOI

      10.1007/s00213-011-2436-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390041, KAKENHI-PROJECT-22890228, KAKENHI-PROJECT-23791359, KAKENHI-PROJECT-24659508, KAKENHI-PUBLICLY-23115506
  • [Journal Article] Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia.2011

    • Author(s)
      Takahide Shuto
    • Journal Title

      CNS Neurosci Ther.

      Volume: 17 Pages: 133-139

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791154
  • [Journal Article] Treatment of the psychostimulant-sensitized animal model of schizophrenia.2011

    • Author(s)
      Shuto T, Nishi A.
    • Journal Title

      CNS Neurosci Ther. 17

      Pages: 133-139

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791154
  • [Journal Article] Treatmentof thepsychostimulant-sensitized animal modelof schizophrenia.2011

    • Author(s)
      ShutoT,NishiA.
    • Journal Title

      CNS Neurosci Ther.

      Volume: 17 Pages: 133-139

    • DOI

      10.1111/j.1755-5949.2010.00218.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats2008

    • Author(s)
      Shuto T
    • Journal Title

      Eur J Neurosci

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1 High and D2High receptors in methamhetamine-sensitized rats2008

    • Author(s)
      Shuto T
    • Journal Title

      Eur J Neurosci (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1^<High> and D2^<High> receptors in methamphetamine-sensitized rats.2008

    • Author(s)
      Shuto T, Seeman P, Kuroiwa M, Nishi A.
    • Journal Title

      Eur J Neurosci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Journal Article] Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.2007

    • Author(s)
      Kitaoka S, Furuyashiki T, Nishi A, Shuto T, Koyasu S, Matsuoka T, Miyasaka M, Greengard P, Narumiya S.
    • Journal Title

      J Neurosci 27

      Pages: 12900-12907

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Journal Article] Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist2006

    • Author(s)
      Shuto T
    • Journal Title

      Neuropharmacology 50

      Pages: 991-997

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Journal Article] Role of adenosine Al receptors in the modulation of dopamine DI and adenosine A_<2A> receptor signaling in the neostriatum.2006

    • Author(s)
      Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A.
    • Journal Title

      Neuroscience 141

      Pages: 19-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Journal Article] Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist.2006

    • Author(s)
      Shuto T, Kuroiwa M, Hamamura M, Yabuuchi K, Shimazoe T, Watanabe S, Nishi A, Yamamoto T.
    • Journal Title

      Neuropharmacology 50

      Pages: 991-997

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] 抗うつ作用発現における海馬歯状回ドパミンD1受容体シグナルの役割:SNRIデュロキセチンを用いた検討2020

    • Author(s)
      杉田 研介、首藤 隆秀、黒岩 真帆美、西 昭徳
    • Organizer
      第73回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] 線条体中間部におけるドパミンD1シグナルの制御機構と不随意運動における役割2020

    • Author(s)
      杦山 慶太、黒岩 真帆美、首藤 隆秀、福田 孝一、 西 昭徳
    • Organizer
      第47回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] 抗うつ作用発現における海馬歯状回ドパミンD1受容体シグナルの役割:SNRIデュロキセチンを用いた検討.2020

    • Author(s)
      杉田 研介、首藤 隆秀、黒岩 真帆美、西 昭徳.
    • Organizer
      第73回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19H03410
  • [Presentation] 抗うつ作用発現における海馬歯状回ドパミンD1受容体シグナルの役割:SNRIデュロキセチンを用いた検討2020

    • Author(s)
      杉田 研介,首藤 隆秀,黒岩 真帆美,西 昭徳
    • Organizer
      第73回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-18K07614
  • [Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019

    • Author(s)
      Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A
    • Organizer
      Federation of European Physiology Society (FEPS)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03410
  • [Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019

    • Author(s)
      Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada H, Nishi A
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19H03410
  • [Presentation] Dopamine D1 receptor/cAMP/PKA signaling is differently regulated in subregions of the striatum2019

    • Author(s)
      Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Takaichi Fukuda and Akinori Nishi
    • Organizer
      The 49th Annual meeting of Society for Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関与2019

    • Author(s)
      岡山 彰洋、楠 智華、首藤 隆秀、黒岩 真帆美、西 昭徳
    • Organizer
      第72回 日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-18K07614
  • [Presentation] 線条体における領域別ドパミンD1シグナル制御:片側パーキンソン病モデルによる影響2019

    • Author(s)
      杉山 慶太、黒岩 真帆美、首藤 隆秀、福田 孝一、西 昭徳
    • Organizer
      第72回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019

    • Author(s)
      Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A
    • Organizer
      FEPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] 抗うつ薬の作用発現における海馬歯状回ノルアドレナリン神経伝達の役割と飼育環境 要因との相互作用に関する研究2019

    • Author(s)
      黒岩 真帆美、楠 智華、岡山 彰洋、首藤 隆秀、西 昭徳
    • Organizer
      第72回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] SNRIデュロキセチンの抗うつ作用における海馬歯状回ドパミンD1受容体シグナルの関 与2019

    • Author(s)
      岡山 彰洋、楠 智華、首藤 隆秀、黒岩 真帆美、西 昭徳
    • Organizer
      第72回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] 海馬歯状回ドパミンD1受容体陽性細胞の選択的活性化がマウスのうつ病関連行動に及ぼす影響2019

    • Author(s)
      箱田 恵子、首藤 隆秀、黒岩 真帆美、西 昭徳
    • Organizer
      第72回 日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-18K07614
  • [Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019

    • Author(s)
      Yukie Kawahara, Yuuki Hanada, Yoshinori Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Hiroshi Kawahara, Akinori Nishi
    • Organizer
      6th Congress of AsCNP
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019

    • Author(s)
      Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI.2019

    • Author(s)
      Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
    • Organizer
      6th Congress of AsCNP
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07614
  • [Presentation] 海馬歯状回ドパミンD1受容体陽性細胞の選択的活性化がマウスのうつ病関連行動に及 ぼす影響2019

    • Author(s)
      箱田 恵子、首藤 隆秀、黒岩 真帆美、西 昭徳
    • Organizer
      第72回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI.2019

    • Author(s)
      Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
    • Organizer
      6th Congress of AsCNP
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli.2019

    • Author(s)
      Kawahara Y, Hanada Y, Ohnishi YN, Shuto T, Kuroiwa M, Sotogaku N, Kawahara H, Nishi A.
    • Organizer
      第92回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] Activation of dopamine D1 receptor signaling in the dentate gyrus is required for antidepressant action of SSRI in a mouse model of depression.2019

    • Author(s)
      Mahomi Kuroiwa, Takahide Shuto, Naoki Sotogaku, Akinori Nishi
    • Organizer
      FEPS2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08083
  • [Presentation] Dopamine D1 receptors in the dentate gyrus amplify therapeutic action of SSRI2019

    • Author(s)
      Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi O, Hanada Y, Nishi A
    • Organizer
      6th Congress of AsCNP
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03410
  • [Presentation] Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of SSRI.2019

    • Author(s)
      Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
    • Organizer
      第42回 日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-18K07614
  • [Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression2018

    • Author(s)
      Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
    • Organizer
      第48回北米神経科学会議
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10198
  • [Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression.2018

    • Author(s)
      Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada Y, Nishi A.
    • Organizer
      The 48th Annual Meeting of Society for Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] Fingolimod (FTY720) suppress cocaine-induced hyper locomotion, which attenuate striatal D1-type medium spiny neurons of PKA/DARPP-32 signaling.2018

    • Author(s)
      Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
    • Organizer
      Society for Neuroscience
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI.2018

    • Author(s)
      Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Ohnishi Y, Hanada Y, Nishi A.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] Role of dopamine D1 receptors in antidepressant action of SSRI2018

    • Author(s)
      Shuto T, Kawahara Y, Nishi A.
    • Organizer
      第45回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI2018

    • Author(s)
      Takahide Shuto, Mahomi Kuroiwa, Naoki Sotogaku, Yukie Kawahara, Yoshinori Ohnishi, Yuuki Hanada, Akinori Nishi
    • Organizer
      第18回国際薬理学・臨床薬理学会議
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10198
  • [Presentation] 領域別線条体におけるドパミンシグナル解析2018

    • Author(s)
      杦山 慶太、黒岩 真帆美、 首藤 隆秀、 福田 孝一、 西 昭徳
    • Organizer
      第71回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-16K10198
  • [Presentation] Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression2018

    • Author(s)
      T. SHUTO, M. KUROIWA, N. SOTOGAKU, Y. KAWAHARA, Y. OHNISHI, Y. HANADA, A. NISHI
    • Organizer
      The 48th Annual Meeting of the Society for Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07614
  • [Presentation] 飼育環境が及ぼすストレス応答の変化2017

    • Author(s)
      黒岩 真帆美、杦山 慶太、首藤 隆秀、西 昭徳
    • Organizer
      第 70 回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-16K10198
  • [Presentation] Fingolimod attenuates cocaine-induced locomotor activities in vivo by decreasing PKA/DARPP-32 signaling in striatal D1-type medium spiny neurons.(フィンゴリモドは線条体のドーパミンD1タイプ線条体中型有棘神経細胞でPKA/DARPP-32シグナルを抑制してコカインによる過活動性を減弱させる)2017

    • Author(s)
      上松 謙、首藤 隆秀、小路 純央、内村 直尚、西 昭徳
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] p11 is essential for dopamine responses to rewarding stimuli.2017

    • Author(s)
      Hanada Y, Kawahara Y, Ohnishi Y, Shuto T, Kuroiwa M, Sotogaku N, Nishi A
    • Organizer
      第44回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] Fingolomod attenuate cocaine induced locomotor activity by decreasing PKA/DARPP32 signaling in striatal D1-type medium spiny neurons.2017

    • Author(s)
      Ken Uematsu, Takahide Shuto, Naohisa Uchimura, Akinori Nishi
    • Organizer
      Neuro Science 2017 ( Washington, DC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] 飼育環境が及ぼすストレス応答の変化2017

    • Author(s)
      黒岩 真帆美、杦山 慶太、首藤 隆秀、西 昭徳
    • Organizer
      第70回日本薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] ドーパミンシグナルを制御するDARPP-32:神経タイプ特異的な機能と制御2016

    • Author(s)
      西 昭徳、首藤隆秀
    • Organizer
      日本神経精神薬理学会
    • Place of Presentation
      ソウル
    • Year and Date
      2016-07-02
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] Sphingosine-1-phosphate (S1P) and fingolimod regulate PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms.2016

    • Author(s)
      Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
    • Organizer
      Neuro Science 2016
    • Place of Presentation
      Sandiego convention center
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] Fingolomod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms (フィンゴリモドはスフィンゴシン-1-リン酸受容体を介して線条体中型有棘細胞のPKA/DARPP-32シグナル伝達を制御する)2016

    • Author(s)
      上松 謙、花田 雄樹、首藤 隆秀、小路 純央、内村 直尚、西 昭徳
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] p11, a possible mood regulator, is essential for the reward-related dopamine responses.2016

    • Author(s)
      Y. HANADA, Y. KAWAHARA, Y. OHNISHI, T. SHUTO, M. KUROIWA, N. SOTOGAKU, A.NISHI
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05135
  • [Presentation] コカインで増強される線条体ドーパミン情報伝達に対するレスベラトロールの急性薬理作用2013

    • Author(s)
      首藤隆秀、黒岩真帆美、古賀夕貴、河原幸江、外角直樹、西昭徳
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] 線条体におけるムスカリン受容体を介したDARPP-32リン酸化調節2013

    • Author(s)
      黒岩真帆美、浜田美保、稗田恵理子、首藤隆秀、外角直樹、西昭徳
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] コカインで増強される線条体ドーパミン情報伝達に対するレスベラトロールの急性薬理作用2013

    • Author(s)
      首藤 隆秀
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] コカインにより活性化される線条体ドーパミンD1受容体シグナルに対するレスベラトロールの影響2012

    • Author(s)
      首藤隆秀、黒岩真帆美、古賀夕貴、西昭徳
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] コカインにより活性化される線条体ドーパミンD1受容体シグナルに対するレスベラトロールの影響2012

    • Author(s)
      首藤 隆秀
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用2012

    • Author(s)
      首藤 隆秀、黒 岩 真帆美、古賀 夕貴、西 昭徳
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Year and Date
      2012-11-23
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用2012

    • Author(s)
      首藤 隆秀
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本大学薬学部(熊本)
    • Data Source
      KAKENHI-PROJECT-23791359
  • [Presentation] sirtuin を活性化するresveratrol のコカイン逆耐性現象に対する影響2011

    • Author(s)
      古賀夕貴, 首藤隆秀, 黒岩真帆美, 豊増功次, 西昭徳
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      誌上開催
    • Year and Date
      2011-03-22
    • Data Source
      KAKENHI-PROJECT-21791154
  • [Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine D1 receptor agonism:Effect on the affinity of dopamine D1 and D2 receptor2008

    • Author(s)
      Shuto T
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine D1 receptor agonism:Effect on the affmity of dopamine D1 and D2 receptor2008

    • Author(s)
      Shuto T
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine DI receptor agonism : Effect on the affinity of dopamine Dl and D2 receptor.2008

    • Author(s)
      Shuto T, Seeman P, Nishi A.
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice2007

    • Author(s)
      Shuto T
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] メタンフェタミン逆耐性を消失させるドーパミンD1受容体刺激薬反復投与:線条体ドーパミン受容体親和性および発現数への影響2007

    • Author(s)
      首藤 隆秀
    • Organizer
      第34回日本脳科学会
    • Place of Presentation
      出雲
    • Year and Date
      2007-06-08
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice.2007

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Repeated administration of dopamine D1 receptor agonist reverses the increased proportion of high-affinity dopamine D1 and D2 receptors in methamphetamine-sensitized rats.2007

    • Author(s)
      Shuto T
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-07
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] メタンフェタミン逆耐性を消失させるドーパミンD1受容体刺激薬反復投与:線条体ドーパミン受容体親和性への影響2007

    • Author(s)
      首藤 隆秀
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Repeated administration of dopamine D1 receptor agonist reverses the increased proportion of high-affinity dopamine D1 and D2 receptors in methamphetamine-sensitized rats2007

    • Author(s)
      Shuto T
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Repeated administration of dopamine Dl receptor agonist reverses the increased proportion of high-affinity dopamine Dl and D2 receptors in methamphetamine-sensitized rats.2007

    • Author(s)
      Shuto T, Kuroiwa M, Seeman P, Nishi A
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego in USA
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Reversal of methamphetamine sensitization by chronic dopamine DI agonist administration : affinities and binding-sites of dopamine receptors in the striatum2007

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 34th Annual Meeting of The Japan Brain Science Society
    • Place of Presentation
      Izumo
    • Year and Date
      2007-06-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Reversal of methamphetamine sensitization by chronic dopamine Dl agonist administration : effect on dopamine receptor affinities in the striatum2007

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 60th Annual Meeting of The Japanese Pharmacological Society in Seinan-Bukai
    • Place of Presentation
      Miyazaki
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] メタンフェタミン逆耐性を消失させるドーパミンDl受容体刺激薬反復投与:線条体ドーパミン受容体親和性および発現数への影響2007

    • Author(s)
      首藤 隆秀
    • Organizer
      第34回日本脳科学会
    • Place of Presentation
      出雲
    • Year and Date
      2007-06-08
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] メタンフェタミン逆耐性におけるDARPP-32 in vivoリン酸化の評価2006

    • Author(s)
      首藤 隆秀
    • Organizer
      第8回ブレインサイエンス研究会
    • Place of Presentation
      北九州
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
  • [Presentation] Analysis of DARPP-32 phosphorylation in vivo in methamphetamine-sensitized rats.2006

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 8th Annual Meeting of The Brain Science Kenkyukai
    • Place of Presentation
      Kitakyusyu
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300128
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    # of Collaborated Projects: 10 results
    # of Collaborated Products: 56 results
  • 2.  Kuroiwa Mahomi (20585690)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 40 results
  • 3.  Sotogaku Naoki (60368884)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 17 results
  • 4.  大西 克典 (10626865)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 16 results
  • 5.  KAWAHARA Yukie (10279135)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 11 results
  • 6.  SHIMAMURA Kenji (70301140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HATAKEYAMA Jun (90404350)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Uematsu Ken (60441672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 9.  Niiyama Shuhei (40258455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  高須 修 (90236216)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Greengard Paul
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  Segi Yotam
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Kim Yong
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  Bibb James A
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Oh Yong-Seok
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  MACPHERSON Tom
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  MORITA Makiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  太田 啓介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  都合 亜記暢
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  中村 桂一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 23.  大西 陽子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 24.  渡邉 優香(江副優香)
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  福田 敦夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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