Niiyama Shuhei 新山修平

… Alternative Names

NIIYAMA SHUHEI 新山修平

NIIYAMA Shuhei 新山修平

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Researcher Number	40258455
Affiliation (Current)	2025: 鹿児島大学, 医歯学域鹿児島大学病院, 准教授 2025: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 鹿児島大学, 医歯学域鹿児島大学病院, 准教授 2018: 鹿児島大学, 医歯学域附属病院, 講師 2013 – 2017: 久留米大学, 医学部, 准教授 2008 – 2010: 久留米大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related / Anesthesiology / Emergency medicine Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 55060:Emergency medicine-related / Emergency medicine / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 敗血症関連脳症 / キヌレニン経路 / 敗血症 / テトラヒドロビオプテリン / セロトニン経路 / トリプトファン / メラトニン / サイトカイン / 盲腸結紮穿孔モデル / BH2 … More / BH4 / セロトニン合成経路 / 酸化ストレス応答 / 性ステロイドホルモン / L-キヌレニン / 17βエストラジオール / キヌレニン / CLPモデル / 重症敗血症 / エストロゲン / 脳症 … More Except Principal Investigator 敗血症 / 芳香族モノアミン / 新生児外科疾患 / ビオプテリン代謝産物 / テトラヒドロビオプテリン / 壊死性腸炎 / 鎮静薬 / 神経活動イメージング / 敗血症関連脳症 / 神経イメージング / 敗血症性脳症 / 赤血球変形能 / カドヘリン / 盲腸結紮穿孔モデル / Angiopoietin-1 / VE-カドヘリン / バイオインピーダンス法 / CLP / 血管透過性亢進 / 臓器不全 / 電磁気刺激 / 脳脊髄虚血再灌流傷害 / ポストコンディショニング Less

テトラヒドロビオプテリン・サプライにより新生児壊死性腸炎の中枢機能予後を取戻す
- Principal Investigator
  
  杉田光士郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kagoshima University
インビボ神経イメージングによる敗血症関連脳症に関与する大脳神経回路同定と治療戦略
- Principal Investigator
  
  中原真由美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Crosstalk Analysis of Melatonin and Tetrahydrobiopterin in Sepsis-Related EncephalopathyPrincipal Investigator
- Principal Investigator
  
  Niiyama Shuhei
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathyPrincipal Investigator
- Principal Investigator
  
  Niiyama Shuhei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Kagoshima University
  Kurume University
Control mechanisms and its failure of endothelial hyperpermeability in sepsis: from a view point of erythrocyte and platelet
- Principal Investigator
  
  Takasu Osamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Kurume University
Pathology Elucidation and a Novel Therapeutic Strategy Against Sepsis-associated EncephalopathyPrincipal Investigator
- Principal Investigator
  
  NIIYAMA SHUHEI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Kurume University
Ischemic postconditioning by electric or magnetic stimulation against the reperfusion injury after cerebral or spinal ischemia
- Principal Investigator
  
  HARADA Hideki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kurume University

All 2024 2023 2022 2021 2019 2016 2015 Other

All Journal Article Presentation

[Journal Article] Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate.2024
- Author(s)
  Hara S, Kono H, Suto N, Kojima H, Kishimoto K, Yoshino H, Niiyama S, Kakihana Y, Ichinose H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 4;717 Pages: 150059-150059
- DOI
  10.1016/j.bbrc.2024.150059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291
[Journal Article] Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury.2023
- Author(s)
  Shimono K, Ito T, Kamikokuryo C, Niiyama S, Yamada S, Onishi H, Yoshihara H, Maruyama I, Kakihana Y.
- Journal Title
  
  Thromb J
  
  Volume: 21(1) Issue: 1 Pages: 91-91
- DOI
  10.1186/s12959-023-00536-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291, KAKENHI-PROJECT-21H03033
[Journal Article] Comparison of the levels of neopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-22022
- Author(s)
  Satoshi Hara, Tama Sanatani, Natsu Tachikawa, Yukihiro Yoshimura, Nobuaki Miyata, Hiroaki Sasaki, Risa Kuroda, Chinatsu Kamikokuryo, Tomohiro Eguchi, Shuhei niiyama, Yasuyuki Kakihana, Hiroshi Ichinose
- Journal Title
  
  Heliyon
  
  Volume: - Issue: 5 Pages: e09371-e09371
- DOI
  10.1016/j.heliyon.2022.e09371
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291
[Journal Article] Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice2022
- Author(s)
  Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: - Pages: 929448-929448
- DOI
  10.3389/fphar.2022.929448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291, KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-19K09438
[Journal Article] Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care2021
- Author(s)
  Hatanaka Kosaku、Ito Takashi、Madokoro Yutaro、Kamikokuryo Chinatsu、Niiyama Shuhei、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 8 Pages: 730553-730553
- DOI
  10.3389/fcvm.2021.730553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-20K09291
[Journal Article] Intraperitoneal adipose tissue is strongly related to survival rate in a mouse cecal ligation and puncture model2016
- Author(s)
  Shuhei Niiyama, Osamu Takasu, Teruo Sakamoto and Kazuo Ushijima
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: 5 Issue: 2
- DOI
  10.1038/cti.2016.3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462842
[Presentation] 敗血症におけるテトラヒドロビオプテリンおよびその酸化物の体内変化とNOxとの関係2019
- Author(s)
  政所祐太郎、上國料千夏、新山修平、安田智嗣、垣花泰之
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11098
[Presentation] 敗血症におけるプテリジン関連物質の動態とNOとの関連2019
- Author(s)
  政所祐太郎、上國料千夏、新山修平、安田智嗣、原怜、一瀬宏
- Organizer
  第33回日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-17K11098
[Presentation] Phase angle in bioimpedance analysis and fluid status in critically ill patients2015
- Author(s)
  Takasu O, Tashiro K, Niiyama S, Kambe T, Kannae T, Moroki M, Morita T, Nabeta M, Nakamura A, Shimojyo Y, Mori S, Sakamoto T
- Organizer
  World Congress of the Intensive and Critical Care Medicine
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462842
[Presentation] 敗血症動物モデルでのエストロゲン、キヌレニンによるマウス生存率改善作用
- Author(s)
  新山修平、花田雄樹、外角直樹、高須修、村井恵良、牛島一男、西昭徳
- Organizer
  第36回日本トリプトファン研究会学術集会
- Place of Presentation
  旭川
- Year and Date
  2014-10-17 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25462842

1. TAKASU Osamu (90236216)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 外角直樹 (60368884)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 政所祐太郎 (40794061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 上國料千夏 (50751278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 一瀬宏 (90192492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. HARADA Hideki (30198923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MISHIMA Yasunori (30258470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 原将人 (10330862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 首藤隆秀 (70412541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中原真由美 (90707514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 奥野浩行 (80272417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 城山優治 (90456195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 杉田光士郎 (50781514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 家入里志 (00363359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 大西峻 (10614638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 垣花泰之 (20264426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 矢野圭輔 (30757919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 加治建 (50315420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 武藤充 (70404522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 伊藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 丸山征郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niiyama Shuhei 新山 修平

NIIYAMA SHUHEI 新山 修平

NIIYAMA Shuhei 新山 修平

Research Projects

Research Products

Co-Researchers

テトラヒドロビオプテリン・サプライにより新生児壊死性腸炎の中枢機能予後を取戻す

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インビボ神経イメージングによる敗血症関連脳症に関与する大脳神経回路同定と治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crosstalk Analysis of Melatonin and Tetrahydrobiopterin in Sepsis-Related EncephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control mechanisms and its failure of endothelial hyperpermeability in sepsis: from a view point of erythrocyte and platelet

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathology Elucidation and a Novel Therapeutic Strategy Against Sepsis-associated EncephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ischemic postconditioning by electric or magnetic stimulation against the reperfusion injury after cerebral or spinal ischemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of the levels of neopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-22022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intraperitoneal adipose tissue is strongly related to survival rate in a mouse cecal ligation and puncture model2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 敗血症におけるテトラヒドロビオプテリンおよびその酸化物の体内変化とNOxとの関係2019

Author(s)

Niiyama Shuhei 新山修平

NIIYAMA SHUHEI 新山修平

NIIYAMA Shuhei 新山修平