Kashiwagi Yoichiro 柏木陽一郎

… Alternative Names

KASHIWAGI Yoichiro 柏木陽一郎

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Researcher Number	20598396
Other IDs	https://orcid.org/0000-0002-2290-1542
Affiliation (Current)	2025: 大阪大学, 大学院歯学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪大学, 大学院歯学研究科, 助教 2018 – 2021: 大阪大学, 歯学研究科, 助教 2012 – 2015: 大阪大学, 歯学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology / Periodontal dentistry Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 糖尿病 / 歯周病 / 高血糖 / 歯周病菌 / ディスバイオシス / 腸内細菌 / 腸内細菌叢 / 歯肉上皮細胞 / 腸肝循環 / 糖新生 … More / 口腔内細菌 / IL-8 / 歯肉上皮 / 自然免疫 … More Except Principal Investigator 歯根膜細胞 / 歯周病 / 細胞老化 / オミクス解析 / 数理モデル / RNAシークエンス / 歯周組織再生 / RAMP-1 / 歯根膜神経 / CGRP / 新規機能性足場材 / LbL(Layer-by-Layer)法 / 三次元歯根膜組織 / 血管新生機構 / 血管内皮細胞 / 単球 / オミクス / 病態遷移 / 歯根膜老化制御薬剤 / 加齢 / 老化歯周組織 / 高齢者 / 糖尿病 / オートファジー / フォールディング / コラーゲン / プロテオスタシス / CXCR4/SDF-1 / 老化 / microRNA / 遺伝子発現データ / 遺伝子発現 / p-dentistry / 予防 / ミトコンドリア / 遺伝子発現解析 / マウス歯周病細菌叢 / オミックス解析 / 重症化予測 / 歯周病進行経路 / 歯槽骨吸収 / 細菌叢解析 / マウスモデル / マイクロバイオーム / 歯周病重症化予測 / 相分離 / ネオエピゲノム歯周病治療 / 液相分離 / DNAトポイソメラーゼー / DNAのねじれ / BRD4 / エンハンサー / 炎症 / ATACシークエンス / エピジェネティクス / サイトカインストーム / スーパーエンハンサー / DNA超らせん / エピゲノム / 歯周病治療 / 細胞外基質 / リン酸カルシウム / 石灰化過程 / 骨芽細胞 / 石灰化 / 誘電率顕微鏡 / 基質小胞 / 硬組織 / プロテオーム解析 / メタボローム解析 / ゲノムワイドアプローチ / CLSPN / LIPA / 疾患関連遺伝子 / エクソームシークエンス / SNP / GWAS / エクソームシークエンス解析 / 侵襲性歯周炎 / アセチルコリン / 神経関連分子 / 骨代謝 / 末梢神経 / ムスカリン受容体 / 神経ペプチド Less

歯周病菌嚥下による消化管シグナルを介した糖代謝制御機構の解明Principal Investigator
- Principal Investigator
  
  柏木陽一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  The University of Osaka
Regulation of Periodontal Tissue Aging - A Novel Strategy for Overcoming Periodontal Disease and Diabetes in the Elderly-
- Principal Investigator
  
  山下元三
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
数理モデルに基づく歯周病の病態遷移機序の解明
- Principal Investigator
  
  藤原千春
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Cooperative angiogenesis mechanism in three-dimensional periodontal ligament mimetic organoids.
- Principal Investigator
  
  沢田啓吾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
神経ペプチドCGRPの機能解析に基づく新規歯周組織再生療法開発への挑戦
- Principal Investigator
  
  三木康史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
CXCR4/SDF-1 axis ameliorates the impaired wound healing and tissue regeneration in aged periodontal tissue
- Principal Investigator
  
  池上久仁子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
歯根膜コラーゲンのプロテオスタシス制御に基づく新規歯周治療法の開発
- Principal Investigator
  
  中村友美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
The effects of periodontopathic bacteria on intestinal microbiota and metabolic pathways of bile acidsPrincipal Investigator
- Principal Investigator
  
  Kashiwagi Yoichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Developing prediction of periodontal disease to realize p-dentistry
- Principal Investigator
  
  Fujihara Chiharu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Osaka University
Creation of neo-epigenetic periodontal therapy targeting DNA twist
- Principal Investigator
  
  Yamashita Motozo
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Osaka University
Prediction of periodontal disease progression by a mathematical model
- Principal Investigator
  
  Fujihara Chiharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Activation of the regenerative process of periodontal tissue by elucidating the function of nerve-related molecules
- Principal Investigator
  
  MIKI Koji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Understanding of pathogenesis of aggressive periodontitis by omics data
- Principal Investigator
  
  Shinya Murakami
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Osaka University
Nano-level multimodal analysis of matrix vesicle-mediated biomineralization
- Principal Investigator
  
  Murakami Shinya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Osaka University
Identification of factors inducing hepatic glucose and lipid metabolism abnormalities via intestine and portal vein by periodontal infection using omics analysis.Principal Investigator
- Principal Investigator
  
  Kashiwagi Yoichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
The effects of high glucose and saturated fatty acid on the inflammation and innate immunity in periodontal tissue component cellsPrincipal Investigator
- Principal Investigator
  
  Kashiwagi Yoichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Osaka University
Investigation of pathological changes induced by hyperglycemia or highly saturated fatty acidPrincipal Investigator
- Principal Investigator
  
  KASHIWAGI Yoichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Osaka University

All 2023 2021 2020 2019 2018 2015 2012 2011 2010

All Journal Article Presentation

[Journal Article] Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium.2023
- Author(s)
  Narukawa Y, Sugiyama N, Miura J, Yamashita R, Tominaga S, Izumi Y, Bamba T, Ishihama Y, Kashiwagi Y*, Murakami S*.
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 58(4) Issue: 4 Pages: 813-826
- DOI
  10.1111/jre.13140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18924, KAKENHI-PROJECT-23K09165, KAKENHI-PROJECT-21K09916, KAKENHI-PLANNED-22H05185
[Journal Article] Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model.2021
- Author(s)
  Kashiwagi Y#, Aburaya S#, Sugiyama N#, Narukawa Y, Sakamoto Y, Takahashi M, Uemura H, Yamashita R, Tominaga S, Hayashi S, Nozaki T, Yamada S, Izumi Y, Kashiwagi A, Bamba T, Ishihama Y, Murakami S*.
- Journal Title
  
  Sci. Rep.
  
  Volume: 11(1) Issue: 1 Pages: 18398-18398
- DOI
  10.1038/s41598-021-97868-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05167, KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-20J00905, KAKENHI-PROJECT-21K09916, KAKENHI-PROJECT-21K14784, KAKENHI-PROJECT-21K21084
[Journal Article] Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study2021
- Author(s)
  Koji Miki, Masahiro Kitamura, Kodai Hatta, Kei Kamide, Yasuyuki Gondo, Motozo Yamashita, Masahide Takedachi, Takenori Nozaki, Chiharu Fujihara, Yoichiro Kashiwagi et al
- Journal Title
  
  Sci Rep
  
  Volume: 11(1) Issue: 1 Pages: 14436-14436
- DOI
  10.1038/s41598-021-93872-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21674, KAKENHI-PROJECT-17H02633, KAKENHI-PROJECT-20K07803
[Journal Article] A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey2021
- Author(s)
  Kataoka Shinsuke、Kimura Mitsuo、Yamaguchi Tsuguno、Egashira Kenji、Yamamoto Yu、Koike Yasushi、Ogawa Yuki、Fujiharu Chika、・・・、Kashiwagi Yoichiro、Kitamura Masahiro、Hayashi Takeshi、Nakagawa Tohru、Murakami Shinya
- Journal Title
  
  BMC Oral Health
  
  Volume: 21 Issue: 1 Pages: 644-644
- DOI
  10.1186/s12903-021-01990-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09916
[Journal Article] Association of periodontal disease with atherosclerosis in 70-year-old Japanese older adults2020
- Author(s)
  Kitamura M, Ikebe K, Kamide K, Gondo Y, Yamashita M, Takedachi M, Nozaki T, Fujihara C, Yamada S, Kashiwagi Y, Miki K, Iwayama T, Hatta K, Mihara Y, Kurushima Y et al
- Journal Title
  
  Odontology
  
  Volume: 109 Issue: 2 Pages: 506-513
- DOI
  10.1007/s10266-020-00567-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02982, KAKENHI-PROJECT-19H01069
[Journal Article] A MapReduce-like Deep Learning Model for the Depth Estimation of Periodontal Pockets2019
- Author(s)
  Moriyama Yusuke、Lee Chonho、Date Susumu、Kashiwagi Yoichiro、Narukawa Yuki、Nozaki Kazunori、Murakami Shinya
- Journal Title
  
  The 12th International Joint Conference on Biomedical Engineering Systems and Technologies
  
  Volume: 5 Pages: 388-395
- DOI
  10.5220/0007405703880395
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09573
[Journal Article] High glucose-induced oxidative stress increases IL-8 production in human gingival epithelial cells.2015
- Author(s)
  Kashiwagi Y, Takedachi M, Mori K, Kubota M, Yamada S, Kitamura M, Murakami S
- Journal Title
  
  Oral Diseases
  
  Volume: - Issue: 6 Pages: 578-584
- DOI
  10.1111/odi.12502
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26861812
[Journal Article] Nicotine upregulates IL-8 serection in human gingival epithelial　cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signaling.2012
- Author(s)
  Kashiwagi Y, Yanagita M*, Kojima Y, Shimabukuro Y and Murakami S
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 57 Issue: 5 Pages: 483-490
- DOI
  10.1016/j.archoralbio.2011.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593057, KAKENHI-PROJECT-24792325
[Journal Article] Nicotine upregulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 ・ or porphyromonas gingivalis lipopolysaccharide via nicotinic acethylcholine receptor signaling2012
- Author(s)
  Kashiwagi Y, Yanagita M, Kojima Y, Shimabukuro Y, Murakami S
- Journal Title
  
  Arch Oral Biol
  
  Volume: 57(5) Pages: 483-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792325
[Presentation] 侵襲性歯周炎患者に対して包括的治療を行なった10年経過症例2021
- Author(s)
  柏木陽一郎、北村正博、村上伸也
- Organizer
  第64回秋季日本歯周病学総会
- Data Source
  KAKENHI-PROJECT-19H01069
[Presentation] 糖尿病マウスにおいて歯周病菌が肝臓代謝機能に及ぼす影響2020
- Author(s)
  柏木陽一郎、生川由貴、和泉自泰、杉山直幸、馬場健史、石濱泰、柏木厚典、村上伸也
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] 高血糖状態がヒト歯肉上皮細胞および糖尿病マウス歯肉組織における細胞間接着に及ぼす影響2020
- Author(s)
  生川由貴、富永翔太郎、柏木陽一郎、村上伸也
- Organizer
  第63回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] Intercellular Adhesion of Gingival Epithelium in Hyperglycemia2020
- Author(s)
  Yuki Narukawa, Yoichiro Kashiwagi, Chiaki Morimoto, Keigo Sawada, Masahide Takedachi, Shinya Murakami.
- Organizer
  2020 IADR/ AADR/ CADR General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] 高血糖状態が歯肉上皮の細胞接着に及ぼす影響2020
- Author(s)
  生川由貴、柏木陽一郎、竹立匡秀、村上伸也
- Organizer
  日本歯科保存学会2020年度春季学術大会(第151回)
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] Intercellular Adhesion of Gingival Epithelial Cells in Hyperglycemic Condition2019
- Author(s)
  Yuki Narukawa, Yoichiro Kashiwagi, Chiaki Morimoto, Keigo Sawada, Masahide Takedachi, Shinya Murakami.
- Organizer
  4th Meeting of the International Association for Dental Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] Intercellular Adhesion of Gingival Epithelium in Hyperglycemia2019
- Author(s)
  Yuki Narukawa, Yoichiro Kashiwagi, Chiaki Morimoto, Keigo Sawada, Masahide Takedachi, Shinya Murakami.
- Organizer
  98th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] Porphyromonas gingivalis exacerbates hyperglycemia in diabetic mice via gut dysbiosis2019
- Author(s)
  Yoichiro Kashiwagi, Yuki Narukawa, Shiori Hasegawa, Masahide Takedachi, Yoshihiro Izumi, Takeshi Bamba, Yasushi Ishihama, and Shinya Murakami
- Organizer
  4th Meeting of the International Association for Dental Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] A MapReduce-like Deep Learning Model for the Depth Estimation of Periodontal Pockets2019
- Author(s)
  Yusuke Moriyama, Chonho Lee, Susumu Date, Yoichiro Kashiwagi, Yuki Narukawa, Kazunori Nozaki and Shinya Murakami
- Organizer
  HEALTHINF 2019 12th International Conference on Health Informatics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] 高血糖状態が歯肉上皮の細胞接着に及ぼす影響2019
- Author(s)
  生川由貴、柏木陽一郎、森本千晶、沢田啓吾、竹立匡秀、村上伸也
- Organizer
  第62回　春季日本歯周病学会
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] Therapeutic efficacy of autologous ADMPC transplantation for periodontal tissue regeneration2018
- Author(s)
  Chiaki Morimoto, Masahide Takedachi, Keigo Sawada, Satomi Yamamoto, Asae Hirai, Junpei Shimomura, Yuki Narukawa, Yoichiro Kashiwagi, Tomoaki Iwayama, Masahiro Kitamura, Shinya Murakami
- Organizer
  第66回国際歯科研究学会日本部会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] Clinical Evaluation of Periodontal Tissue Regeneration by ADMPC Transplantation2018
- Author(s)
  Masahide Takedachi, Keigo Sawada, Chiaki Morimoto, Satomi Yamamoto, Asae Hirai, Junpei Shimomura, Yuki Narukawa, Yoichiro Kashiwagi, Tomoaki Iwayama, Masahiro Kitamura, Shinya Murakami
- Organizer
  96th General Session and Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09573
[Presentation] 高血糖状態が歯周組織構成細胞のIL-8産生に及ぼす影響2012
- Author(s)
  柏木陽一郎
- Organizer
  第55回秋季日本歯周病学会学術大会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-24792325
[Presentation] 高血糖状態が歯周組織構成細胞のIL-8 産生に及ぼす影響2012
- Author(s)
  柏木陽一郎, 山田聡, 北村正博, 村上伸也
- Organizer
  第55回秋季日本歯周病学会学術大会
- Year and Date
  2012-09-23
- Data Source
  KAKENHI-PROJECT-24792325
[Presentation] ニコチンと高血糖の歯肉上皮細胞における自然免疫応答に及ぼす影響2011
- Author(s)
  柏木陽一郎, 柳田学, 山田聡, 北村正博, 村上伸也
- Organizer
  第54回秋季日本歯周病学会学術大会
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-24792325
[Presentation] 高血糖とニコチンが歯肉上皮細胞の自然免疫応答に及ぼす影響2010
- Author(s)
  柏木陽一郎, ほか
- Organizer
  第25回糖尿病合併症学会
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-24792325

1. Shinya Murakami (70239490)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. Yamashita Motozo (90524984)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. MIKI Koji (10598395)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. Fujihara Chiharu (00755358)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 岩山智明 (80757865)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
6. 北村正博 (10243247)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 竹立匡秀 (60452447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 岡田眞里子 (10342833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 沢田啓吾 (70733054)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 石濱泰 (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 小椋俊彦 (70371028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 和泉自泰 (70622166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 池上久仁子 (80779116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中村友美 (00807589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 三浦博己 (30219589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 柳田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kashiwagi Yoichiro 柏木 陽一郎

KASHIWAGI Yoichiro 柏木 陽一郎

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歯周病菌嚥下による消化管シグナルを介した糖代謝制御機構の解明Principal Investigator

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The effects of periodontopathic bacteria on intestinal microbiota and metabolic pathways of bile acidsPrincipal Investigator

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Identification of factors inducing hepatic glucose and lipid metabolism abnormalities via intestine and portal vein by periodontal infection using omics analysis.Principal Investigator

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Kashiwagi Yoichiro 柏木陽一郎

KASHIWAGI Yoichiro 柏木陽一郎

[Journal Article] Nicotine upregulates IL-8 serection in human gingival epithelial　cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signaling.2012