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TSUJITA TADAYUKI  辻田 忠志

… Alternative Names

Tsujita Tadayuki  辻田 忠志

TSUJITA Tadayuki  辻田 忠志

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Researcher Number 20622046
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-7189-0376
Affiliation (Current) 2025: 佐賀大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 佐賀大学, 農学部, 准教授
2016 – 2022: 佐賀大学, 農学部, 講師
2013 – 2014: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Applied health science / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Health science and related fields
Except Principal Investigator
Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 38010:Plant nutrition and soil science-related
Keywords
Principal Investigator
Nrf1 / 老化 / 酸化ストレス / ポリアミン / 低酸素 / ストレス / スペルミジンオキシだーぜ / 不良タンパク質蓄積 / リボソーム衝突 / リポソームコリジョン … More / アクロレイン / PHD-HIF系 / 低酸素応答 / HIF / PHD / PHD/HIF / 低分子化合物 / 代謝異常 / ERストレス / アミノ酸代謝 / Nrf1/2 / 代謝 / 転写因子 / 酸素 / 安全性試験 / 初代培養 / 肝細胞 / レドックスバランス / 加齢・老化 / グルタチオン / NRF1 / 還元ストレス … More
Except Principal Investigator
polymorphism / 飲酒 / バイオマーカー / メラノーシス / メラノーマ / アセトアルデヒド / エタノール / メラニン / 発がん / アルデヒド / 遺伝子多型 / ALDH2 / 栄養応答 / 無機栄養 / シロイヌナズナ / 選択的スプライシング / カリウム Less
  • Research Projects

    (8 results)
  • Research Products

    (74 results)
  • Co-Researchers

    (23 People)
  •  New strategic approach for ameliorate hypoxic injury using the PHD1 specific inhibitor and definition of the molecular mechanism.Principal Investigator

    • Principal Investigator
      辻田 忠志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Saga University
  •  Molecular mechanisms of the alternative splicing regulation in response to a variable nutrient environment in plants

    • Principal Investigator
      西田 翔
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38010:Plant nutrition and soil science-related
    • Research Institution
      Saga University
  •  Controlling the anti aging mechanism through modification of the protein translation pathway and Amine metabolizing pathwayPrincipal Investigator

    • Principal Investigator
      辻田 忠志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Saga University
  •  Alcohol and rs671 on melanoma development: an experimental approach

    • Principal Investigator
      松本 明子
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Saga University
  •  Controlling the aging and metabolic process with anti-stress enzyme expression profiles through those controlling transcriptional factor, Nrf1Principal Investigator

    • Principal Investigator
      TSUJITA Tadayuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Saga University
  •  Development the culture method for primary hepatocyte to keeping a same response range in vitro and in vivo for exogenous stimulus.Principal Investigator

    • Principal Investigator
      Tsujita Tadayuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Health science and related fields
    • Research Institution
      Saga University
  •  Modulation and/or controlling of the aging event by the basic anti-oxidative response with environmental transcriptional factor Nrf1Principal Investigator

    • Principal Investigator
      Tsujita Tadayuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Applied health science
    • Research Institution
      Saga University
  •  Does adjusting Nrf1 active status lead to remediate reductive stress and aging-related diseases?Principal Investigator

    • Principal Investigator
      TSUJITA Tadayuki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied health science
    • Research Institution
      Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent

  • [Book] 酸化ストレス認識分子基盤と創薬応用」生命科学から創薬へのイノベーション2014

    • Author(s)
      辻田 忠志, 山本 雅之
    • Total Pages
      202
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-25750357
  • [Journal Article] Emerging Role of GCN1 in Disease and Homeostasis2024

    • Author(s)
      Yota Tatara, Shuya Kasai, Daichi Kokubu, Tadayuki Tsujita, Junsei Mimura, and Ken Itoh
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 5 Pages: 2998-2998

    • DOI

      10.3390/ijms25052998

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06891, KAKENHI-PROJECT-23K24772
  • [Journal Article] The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis2023

    • Author(s)
      Hatanaka Atsushi、Nakada Sota、Matsumoto Gen、Satoh Katsuya、Aketa Iori、Watanabe Akira、Hirakawa Tomoaki、Tsujita Tadayuki、Waku Tsuyoshi、Kobayashi Akira
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 14405-14405

    • DOI

      10.1038/s41598-023-41492-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07417, KAKENHI-PUBLICLY-22H04651, KAKENHI-PUBLICLY-22H04659, KAKENHI-PROJECT-23K24214, KAKENHI-PROJECT-23K24772, KAKENHI-PROJECT-23K28007
  • [Journal Article] Identification and mechanistic investigation of ellagitannins from <i>Osbeckia octandra</i> that attenuate liver fibrosis via the TGF-<i>β</i>/SMAD signaling pathway2023

    • Author(s)
      Bogahawaththa Sudarma、Kawamura Tomoaki、Bandaranayake Udari、Hirakawa Tomoaki、Yamada Goki、Ishino Hana、Hirohashi Tsuzumi、Kawaguchi Shin-ichi、Wijesundera Kavindra K、Wijayagunawardane Missaka P B、Ishimaru Kanji、Kodithuwakku Suranga P、Tsujita Tadayuki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 87 Issue: 11 Pages: 1295-1309

    • DOI

      10.1093/bbb/zbad114

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K24772
  • [Journal Article] Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors2022

    • Author(s)
      Sonoda Kento、Ujike Saki、Katayama Akito、Suzuki Norio、Kawaguchi Shin-ichi、Tsujita Tadayuki
    • Journal Title

      Bioorganic and Medicinal Chemistry

      Volume: 73 Pages: 117039-117039

    • DOI

      10.1016/j.bmc.2022.117039

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K21372
  • [Journal Article] Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress2022

    • Author(s)
      Kento Sonoda , Sudarma Bogahawatta, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-ichi Kawaguchi, and Tadayuki Tsujita*
    • Journal Title

      ACS Pharmacol. Transl. Sci.

      Volume: 5 Issue: 5 Pages: 362-372

    • DOI

      10.1021/acsptsci.2c00002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17746, KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K21372
  • [Journal Article] Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis2021

    • Author(s)
      Bogahawaththa Sudarma、Kodithuwakku Suranga P.、Wijesundera Kavindra K.、Siriweera Eranga H.、Jayasinghe Lalith、Dissanayaka Waruna L.、Rajapakse Jayanthe、Herath Chandana B.、Tsujita Tadayuki、Wijayagunawardane Missaka P. B.
    • Journal Title

      Molecules

      Volume: 26 Issue: 16 Pages: 4836-4836

    • DOI

      10.3390/molecules26164836

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Journal Article] Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-12018

    • Author(s)
      Kawaguchi Shin-Ichi, Gonda Yuhei, Yamamoto Takuya, Sato Yuki, Shinohara Hiroyuki, Kobiki Yohsuke, Ichimura Atsuhiko, Dan Takashi, Sonoda Motohiro, Miyata Toshio, Ogawa Akiya, Tsujita Tadayuki
    • Journal Title

      Molecules

      Volume: 23 Issue: 4 Pages: 885-885

    • DOI

      10.3390/molecules23040885

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04138, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-16K14049, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17K19881
  • [Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018

    • Author(s)
      Sekine Hiroki、Okazaki Keito、Kato Koichiro、Alam M. Morshedul、Shima Hiroki、Katsuoka Fumiki、Tsujita Tadayuki、Suzuki Norio、Kobayashi Akira、Igarashi Kazuhiko、Yamamoto Masayuki、Motohashi Hozumi
    • Journal Title

      Molecular and Cellular Biology

      Volume: 38 Issue: 17 Pages: 00252-18

    • DOI

      10.1128/mcb.00252-18

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-17K19680, KAKENHI-PROJECT-17K19916, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-16H03265, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K08618
  • [Journal Article] Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish2018

    • Author(s)
      Mukaigasa Katsuki、Tsujita Tadayuki、Nguyen Vu Thanh、Li Li、Yagi Hirokazu、Fuse Yuji、Nakajima-Takagi Yaeko、Kato Koichi、Yamamoto Masayuki、Kobayashi Makoto
    • Journal Title

      Proc. Natl. Acad. Sci.

      Volume: 115 Issue: 11 Pages: 2758-2763

    • DOI

      10.1073/pnas.1714056115

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17J04162, KAKENHI-PROJECT-26520101
  • [Journal Article] A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis2017

    • Author(s)
      Ito Ryo、Sato Ikuko、Tsujita Tadayuki、Yokoyama Atsushi、Sugawara Akira
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 489 Issue: 1 Pages: 21-28

    • DOI

      10.1016/j.bbrc.2017.05.109

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16K19550
  • [Journal Article] Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.2017

    • Author(s)
      Baird L, Tsujita T, Kobayashi E, Funayama R, Nagashima T, Nakayama K, and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 4

    • DOI

      10.1128/mcb.00439-16

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664
  • [Journal Article] Time-resolved Fluorescent Detection for Glucose Using a Complex of Luminescent Layered Titanates and Enzymes2017

    • Author(s)
      SAKAGUCHI Yuki、MINAMIKAWA Tomoka、YAMAMURO Mayuko、TSUJITA Tadayuki、UEDA Toshihisa、KAMADA Kai、SOH Nobuaki
    • Journal Title

      Anal. Sci.

      Volume: 33 Issue: 9 Pages: 989-991

    • DOI

      10.2116/analsci.33.989

    • NAID

      130006071189

    • ISSN
      0910-6340, 1348-2246
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-15K05542
  • [Journal Article] Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.2017

    • Author(s)
      Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M.
    • Journal Title

      Free Radic Biol Med

      Volume: 103 Pages: 236-247

    • DOI

      10.1016/j.freeradbiomed.2016.12.041

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16H06639, KAKENHI-PROJECT-16H07149, KAKENHI-PROJECT-26461395
  • [Journal Article] Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings2017

    • Author(s)
      Kaneko Hiroshi、Katoh Takehide、Hirano Ikuo、Hasegawa Atsushi、Tsujita Tadayuki、Yamamoto Masayuki、Shimizu Ritsuko
    • Journal Title

      Genes Cells

      Volume: 22 Issue: 11 Pages: 939-952

    • DOI

      10.1111/gtc.12537

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922
  • [Journal Article] Intracellular thiol contents and fatty acid metabolism pathways are regulated by the Nrf1 (NFE2L1) with its transcriptional suppressor activity2016

    • Author(s)
      辻田 忠志
    • Journal Title

      生化学

      Volume: 88 Issue: 6 Pages: 776-781

    • DOI

      10.14952/SEIKAGAKU.2016.880776

    • NAID

      40021054408

    • ISSN
      0037-1017
    • Year and Date
      2016-12-25
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Journal Article] Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.2015

    • Author(s)
      Tsujita T, Baird L, Furusawa Y, Katsuoka F, Hou Y, Gotoh S, Kawaguchi S-i, and Yamamoto M.
    • Journal Title

      Genes Cells

      Volume: 7 Issue: 7 Pages: 563-577

    • DOI

      10.1111/gtc.12248

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26860168
  • [Journal Article] Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway.2015

    • Author(s)
      Nishikawa et al.
    • Journal Title

      Nature Medicine

      Volume: 21 Issue: 3 Pages: 281-287

    • DOI

      10.1038/nm.3774

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22113007, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116719, KAKENHI-PROJECT-26670673, KAKENHI-PROJECT-26713010, KAKENHI-PROJECT-25253070
  • [Journal Article] Hypoxia-Sensitive Reporter System for High-Throughput Screening2015

    • Author(s)
      Tsujita, T.; Kawaguchi, S-i.; Dan, T.; Baird, L.; Miyata, T.; Yamamoto, M.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 235 Issue: 2 Pages: 151-159

    • DOI

      10.1620/tjem.235.151

    • NAID

      130004822440

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J05784, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860168
  • [Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.2014

    • Author(s)
      Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 19 Issue: 8 Pages: 650-665

    • DOI

      10.1111/gtc.12165

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26893008
  • [Journal Article] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes2014

    • Author(s)
      Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, and Hayes JD.
    • Journal Title

      Mol Cell Biol

      Volume: 34 Issue: 20 Pages: 3800-3816

    • DOI

      10.1128/mcb.00110-14

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460383
  • [Journal Article] Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.2014

    • Author(s)
      Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, and Kensler TW.
    • Journal Title

      Toxicol Sci

      Volume: 141 Issue: 1 Pages: 112-119

    • DOI

      10.1093/toxsci/kfu109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25750357
  • [Patent] 新規な含窒素環状化合物及びその用途2020

    • Inventor(s)
      川口真一, 辻田忠志
    • Industrial Property Rights Holder
      佐賀大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-174971
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] Hep3B細胞におけるKlothoノックダウンがアミノ酸飢餓応答とNrf1に与える影響2023

    • Author(s)
      川村 友秋, Sudarma Bogahawaththa, 志賀 奏, 辻田 忠志
    • Organizer
      第96回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] 2-OG骨格を持たない新規HIF-PH阻害薬PyrzA2023

    • Author(s)
      川口 真一, 濱田 悠菜, 氏家 沙綺, 園田 健登, 辻田 忠志.
    • Organizer
      第45回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K19755
  • [Presentation] バキュロウイルス発現系によるPHDタンパク質大量発現と精製条件の検討2023

    • Author(s)
      吉竹 紀子, 園田 健登, 伴 匡人, 辻田 忠志
    • Organizer
      第45回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K19755
  • [Presentation] 内因性ストレス制御を目指したポリアミン代謝機能調節の試み2023

    • Author(s)
      辻田 忠志
    • Organizer
      第96回日本生化学会大会「神秘の生命物質、ポリアミンで実現する健康長寿社会」シンポジウム,
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] 転写因子Nrf1によるポリアミン代謝制御とアクロレイン産生2023

    • Author(s)
      平川 智章, 谷内 めぐみ,吉竹 紀子, 末次 祐大, 井口 瑶子, 植村 武史, 辻田 忠志.
    • Organizer
      日本ポリアミン学会第13回年会
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein2023

    • Author(s)
      Tomoaki HIRAKAWA, Megumi TANIUCHI, Yoko IGUCHI, Kiko YOSHITAKE, Yudai SUETSUGU, Takeshi UEMURA, Tadayuki TSUJITA
    • Organizer
      The Environmental Response VI
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] Transcription factor Nrf1 can control polyamine metabolic pathway and acrolein production2023

    • Author(s)
      Tomoaki HIRAKAWA, Megumi TANIUCHI, Yoko IGUCHI, Kiko YOSHITAKE, Takeshi UEMURA, Tadayuki TSUJITA
    • Organizer
      Gordon Research Conference "Polyamines in Cancer, Medical Genetics, Aging, Pathogens and Plants"
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] SelSを介する小胞体逆輸送機構とNrf1核移行の関連解析2023

    • Author(s)
      北 毬乃, 山田 剛暉, 辻田 忠志.
    • Organizer
      第45回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway2023

    • Author(s)
      Sudarma Bogahawaththa, Tomoaki Kawamura, Tomoaki Hirakawa, Hana Ishino, Tsuzumi Hirohashi, Shin-ichi Kawaguchi, Kanji Ishimaru, Suranga P. Kodithuwakku, Tadayuki Tsujita
    • Organizer
      第45回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] Investication of relationship between GCN1 and NRF1 expression during aging in aging model mice and siRNA knockdown cells2023

    • Author(s)
      Sudarma BOGAHAWATHTHA, Tomoaki KAWAMURA, Kanade SHIGA, Goki YAMADA, Yo-Ichi NABESHIMA, Ken ITOH, Tadayuki TSUJITA
    • Organizer
      The Environmental Response VI
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] Nrf1タンパク質量を調節する小胞体逆輸送機構の解析2022

    • Author(s)
      山田 剛暉, 馬 禎珠, 田上 愛祐美, 平川 智章, ボガハワッタ スダーマ, 川村 友秋, 辻田 忠志.
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] Hep3B細胞におけるKlothoノックダウンがアミノ酸飢餓応答とNrf1に与える影響2022

    • Author(s)
      川村 友秋, Sudarma Bogahawaththa, 志賀 奏, 辻田 忠志
    • Organizer
      第44回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] Nrf1 Upregulation Influence on Cellular Glucose Deficiency; using Stably Expressed Nrf1 Tet-on system2022

    • Author(s)
      Shanika Werellagama, Megumi Matsumoto, Mami Sato, Kento Sonoda, Tomoaki Kawamura, Marcus Conrad, Tadayuki Tsujita
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] 新たな骨格を持つPHD活性阻害剤PyrzAの創出と構造活性相関研究2022

    • Author(s)
      辻田 忠志, 園田 健登, 氏家 沙綺, 片山 彰人, 鈴木 教郎 川口 真一
    • Organizer
      第18回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-22K19755
  • [Presentation] Identification of a Novel Aging Controller and its Competitors in an Aging Mouse Model2022

    • Author(s)
      Sudarma Bogahawaththa, Tomoaki Kawamura, Kanade Shiga, Yo-Ichi Nabeshima, Ken Itoh, Tadayuki Tsujita
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] 転写因子Nrf1によるステロイド5αリダクターゼの調節解析2022

    • Author(s)
      マ ジョンジュ, 山田 剛暉, 平川 智章, Bogahawaththa Sudarma, 川村 友秋, 下村 隆, 辻田 忠志.転写因子Nrf1によるステロイド5αリダクターゼの調節解析
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] タンパク質恒常性の維持・老化と関連する環境転写因子Nrf1の解析2022

    • Author(s)
      辻田 忠志
    • Organizer
      佐賀大学SDGsプロジェクト研究所「皮膚科学に関する知の拠点形成プロジェクト」第一回シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] タンパク質恒常性の維持・老化と関連する環境転写因子Nrf1の解析2022

    • Author(s)
      辻田 忠志
    • Organizer
      佐賀大学SDGsプロジェクト研究所「皮膚科学に関する知の拠点形成プロジェクト」第一回シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19755
  • [Presentation] 新規Nrf1標的遺伝子Smoxとアクロレイン産生機序の解明2022

    • Author(s)
      平川 智章, 谷内 めぐみ, 井口 瑶子, 吉竹 紀子, 植村 武史, 辻田 忠志
    • Organizer
      第44回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K24772
  • [Presentation] 低酸素ストレスから防御する新奇HIF活性化剤PyrzAの発見2022

    • Author(s)
      園田 健登, 片山 彰人, 氏家 沙綺, 黒木 紗英, 北川 尚穂, 廣津留 倖一, 川口 真一, 辻田 忠志
    • Organizer
      第95回日本生化学会大会.
    • Data Source
      KAKENHI-PROJECT-22K19755
  • [Presentation] ストレス応答性転写因子Nrf1によるアミノ酸の取込および感知機構の制御2021

    • Author(s)
      辻田忠志
    • Organizer
      12回トランスポーター研究会九州部会・シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] 含硫化合物が起点となる細胞内ストレス耐性機構の調節2021

    • Author(s)
      辻田忠志
    • Organizer
      第94回日本生化学大会 ・シンポジウム「含硫化合物・温故知新―生物多様性に学ぶ含硫代謝物の多彩な生理作用」
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] Smox過剰発現によるポリアミンインバランス誘導と内因的に発生するアクロレインの評価2020

    • Author(s)
      平川智章, 辻田忠志
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] Nrf1欠失細胞における外来ストレス応答度の変化と分子メカニズム解析2020

    • Author(s)
      松本めぐみ, 辻田忠志
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] ポリアミン代謝の不均衡による内因性アクロレインの発生と肝疾患2019

    • Author(s)
      辻田忠志.
    • Organizer
      第42回日本分子生物学会年会, フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] Discovering the sunny and dark side of Nrf1 transcriptional factor and its utilization2019

    • Author(s)
      Tadayuki Tsujita
    • Organizer
      31st annual congress of the PGIA
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] Accumulation of the acrolein conjugated protein in Nrf1 knockout mice and cellular model.2019

    • Author(s)
      Tadayuki Tsujita, Megumi Taniuchi, Tomoaki Hirakawa, Minami Kudo, Megumi Matsumoto, Kanade Shiga
    • Organizer
      The Environmental response V
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] 早期老化α-Klotho-/-マウスおよび加齢マウスを用いた老化指標の探索2019

    • Author(s)
      志賀奏, 辻田忠志
    • Organizer
      第43回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-19H04057
  • [Presentation] Discovering the sunny and dark side of Nrf1 transcriptional factor and its utilization2019

    • Author(s)
      Tadayuki Tsujita
    • Organizer
      31st annual congress of the PGIA
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] 肝特異的Nrf1欠失マウスにおけるNAFLDとアクロレイン化タンパク質の関連解析2018

    • Author(s)
      谷内めぐみ, 井口瑶子, 辻田忠志.
    • Organizer
      日本ポリアミン学会第10回年会
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] PHDタンパク質にアロステリックに作用し、低酸素応答因子HIFを安定化する新規化合物の探索2018

    • Author(s)
      園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] PHDタンパク質にアロステリックに作用し、低酸素応答因子HIFを安定化する新規化合物の探索.2018

    • Author(s)
      園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
    • Organizer
      第91回日本生化学会大会. 国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] 転写因子Nrf1による生体恒常性維持機構の解明2018

    • Author(s)
      辻田忠志
    • Organizer
      第32回HiHA(広島大学健康長寿研究拠点)セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] 分子選択的なHIF活性化低分子化合物の開発2018

    • Author(s)
      黒木紗英, 辻田忠志, 川口真一
    • Organizer
      第42回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] HIF分解を制御するPHDタンパク質をアロステリックに阻害する新規化合物の探索.2018

    • Author(s)
      園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
    • Organizer
      平成 30年度日本生化学会九州支部例会
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] HIF分解を制御するPHDタンパク質をアロステリックに阻害する新規化合物の探索2018

    • Author(s)
      園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志.
    • Organizer
      平成 30年度日本生化学会九州支部例会
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] アロステリックなPHD活性阻害によるHIF誘導低分子化合物の創出.2017

    • Author(s)
      廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
    • Organizer
      第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] Functional analysis and advanced application for drug discovery with environmental response transcriptional factors2017

    • Author(s)
      辻田忠志
    • Organizer
      第6回脳科学セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] ストレス応答転写因子Nrf1を特異的に安定化する誘導剤の探索.2017

    • Author(s)
      福元 雄大, 辻田 忠志, 川口 真一.
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] リガンド2OGの構造に基づいた分子設計による低酸素誘導因子の活性化2017

    • Author(s)
      黒木紗英, 辻田忠志, 川口真一
    • Organizer
      第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] ストレス応答転写因子Nrf1を特異的に活性化する誘導剤の探索.2017

    • Author(s)
      福元雄大, 辻田 忠志.
    • Organizer
      平成 29年度日本生化学会九州支部例会
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] 唐津地産抽出物ライブラリーに含まれる有効成分の培養細胞による評価抗酸化活性を評価できるモニター細胞の創出とその応用2017

    • Author(s)
      辻田忠志
    • Organizer
      第5回JCC産学交流セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19916
  • [Presentation] Possible link and future direction between stress transcriptional factor Nrf1/2 and NGLY12017

    • Author(s)
      Tadayuki TSUJITA
    • Organizer
      4th Global NGLY1 Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] 環境転写因子Nrf1を特異的に活性化する化合物の探索2016

    • Author(s)
      廣津留 倖一, 川口 真一, 山本 雅之, 辻田 忠志.
    • Organizer
      第40回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      指宿
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] 転写因子NRF1のOGT-HCF-1複合体を介した分解制御機構2016

    • Author(s)
      関根 弘樹, 加藤 幸一郎, 福田 愛菜, 鈴木 教郎, 岡崎 慶斗, アラム モシェッド. 辻田 忠志, 小林 聡, 山本 雅之, 本橋 ほづみ
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] Nrf1タンパク質の活性化状態を直接モニターできるレポーター培養細胞による大規模化合物スクリーニングとNrf1に特異的な活性化化合物の創出2016

    • Author(s)
      辻田 忠志, Liam Baird, 古澤 祐樹, 勝岡 史樹, 彭 よしか, 後藤 智美, 川口 真一, 山本 雅之.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H05922
  • [Presentation] Transcription factor Nrf1 negatively regulates the cystine transporter and lipid metabolic enzymes to prevent over-nutrition in hepatocytes2014

    • Author(s)
      Tsujita T, Mullin V, Baird L, Matsuyama Y,Takaku M,Walsh SV,Griffin JL,Yamamoto M and Hayes JD
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-25750357
  • [Presentation] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes2014

    • Author(s)
      Tsujita T, Mullin V, Baird L, Matsuyama Y,Takaku M,Walsh SV,Griffin JL,Yamamoto M and Hayes JD
    • Organizer
      The Environmental Response IV
    • Place of Presentation
      Sendai, Japan
    • Data Source
      KAKENHI-PROJECT-25750357
  • [Presentation] 転写因子Nrf1はシステイン・グルタミントランスポーターおよび脂質代謝酵素群を抑制制御する

    • Author(s)
      辻田 忠志, Vivian Mullin, Liam Baird, 松山 由香, 高久 美咲, Shawn Walsh, Julian Griffin, 山本 雅之, John Hayes
    • Organizer
      第25回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25750357
  • [Presentation] 転写因子Nrf1はシステイントランスポーターおよび脂質代謝酵素群を抑制制御する

    • Author(s)
      辻田 忠志, Vivian Mullin, Liam Baird, 松山 由香, 高久 美咲, Shawn Walsh, Julian Griffin, 山本 雅之, John Hayes.
    • Organizer
      第25回日本生体防御学会学術総会
    • Place of Presentation
      さくらホール(仙台市)
    • Year and Date
      2014-07-09 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-25750357
  • [Presentation] 転写因子Nrf1はシステイントランスポーターおよび脂質代謝酵素群を抑制制御する

    • Author(s)
      辻田忠志
    • Organizer
      第56回脳研・高度先進合同セミナー(『心の遺伝子』研究コンソーシアム研究セミナー)
    • Place of Presentation
      青森県・弘前市・弘前大学医学部
    • Invited
    • Data Source
      KAKENHI-PROJECT-25750357
  • 1.  水沼 正樹 (10343295)
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  • 13.  SUZUKI Norio
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