Senoh Mitsutoshi 妹尾充敏

Researcher Number	20646624
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細菌第二部, 室長
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立感染症研究所, 細菌第二部, 室長 2016 – 2020: 国立感染症研究所, 細菌第二部, 主任研究官 2015: 国立感染症研究所, その他部局等, 主任研究官 2013 – 2014: 国立感染症研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) Except Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Basic Section 58070:Lifelong developmental nursing-related
Keywords	Principal Investigator CDI / Clostridioides difficile / 糞便移植療法 / ワクチン / Clostridium difficile / 治療因子 / クロストリディオイデス・ディフィシル感染症 / 毒素 / DNAワクチン / Vaccine / Membrane fraction / 定着因子 … More Except Principal Investigator … More Clostridioides difficile / VBNC / カタラーゼ / コレラ菌 / バクテリオファージ / ジフテリア菌 / 培養可能 / ウルセランス菌 / 支援 / 感染予防 / 小児 / 学校生活 / 在宅療養 / 炎症性腸疾患 / こども / 感染予防看護 / 宿主認識機構 / 腸内微生物叢 / 溶菌酵素 / ディフィシル菌 / CDI / クロストリディオイデス・ディフィシル感染症 / 予防 / 治療 / ディスバイオシス / 尾部吸着分子 / 宿主特異性 / C. difficile感染症 / 培養可能状態 / RNAマイクロアレイ / 伝達 / 細菌 / プロテオーム解析 / ゲノム解析 / ファージ変換 / 構造タンパク質 / ビリオンタンパク質 / 水平伝播 / ボツリヌス毒素遺伝子 / ボツリヌス症 / 人畜共通感染症 / ボツリヌス菌 Less

Clostridioides difficile感染症に対する糞便移植療法の治療因子の同定と作用解析Principal Investigator
- Principal Investigator
  
  妹尾充敏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
Research on the conversion mechanism from VBNC to culturable in pathogenic bacteria
- Principal Investigator
  
  濱端崇
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Center for Global Health and Medicine
在宅で療養する炎症性腸疾患患児の感染予防のための支援方法の構築
- Principal Investigator
  
  村端真由美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58070:Lifelong developmental nursing-related
- Research Institution
  Mie University
Development of new treatment method for Clostridioides difficile infectionPrincipal Investigator
- Principal Investigator
  
  Senoh Mitsutoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
Study for a molecular machinery of the host recognition by Clostridioides difficile phage to develop the advanced therapy
- Principal Investigator
  
  Sakaguchi Yoshihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kitasato University
Study of the molecular machinery of host recognition by the Clostridium botulinum type C and D neurotoxin-converting phages
- Principal Investigator
  
  Sakaguchi Yoshihiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kitasato University
Development of DNA vaccine for Clostridium difficile infectionPrincipal Investigator
- Principal Investigator
  
  Senoh Mitsutoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases
Study on the conversion from VBNC to culturable state in Vibrio cholerae
- Principal Investigator
  
  Hamabata Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Center for Global Health and Medicine
Development of vaccine for Clostridium difficile infection using membrane fractionPrincipal Investigator
- Principal Investigator
  
  Senoh Mitsutoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases

All 2023 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Gene expression analysis during the conversion from a viable but nonculturable to culturable state in Vibrio cholerae2023
- Author(s)
  Ayibieke Alafate、Nishiyama Ayae、Senoh Mitsutoshi、Hamabata Takashi
- Journal Title
  
  Gene
  
  Volume: 863 Pages: 147289-147289
- DOI
  10.1016/j.gene.2023.147289
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07064, KAKENHI-PROJECT-22K15466
[Journal Article] Development of vaccine for Clostridium difficile infection using membrane fraction of nontoxigenic Clostridium difficile2018
- Author(s)
  Senoh Mitsutoshi、Iwaki Masaaki、Yamamoto Akihiko、Kato Haru、Fukuda Tadashi、Shibayama Keigo
- Journal Title
  
  Microbial Pathogenesis
  
  Volume: 123 Pages: 42-46
- DOI
  10.1016/j.micpath.2018.06.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19132
[Journal Article] Inhibition of adhesion of Clostridium difficile to human intestinal cells after treatment with serum and intestinal fluid isolated from mice immunized with nontoxigenic C. difficile membrane fraction.2015
- Author(s)
  Senoh M, Iwaki M, Yamamoto A, Kato H, Fukuda T, Shibayama K.
- Journal Title
  
  Microb Pathog.
  
  Volume: 81 Pages: 1-5
- DOI
  10.1016/j.micpath.2015.03.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860327
[Journal Article] Predominance of PCR-ribotypes, 018 (smz) and 369 (trf) of Clostridium difficile in Japan: a potential relationship with other global circulating strains?2015
- Author(s)
  Senoh M, Kato H, Fukuda T, Niikawa A, Hori Y, Hagiya H, Ito Y, Miki H, Abe Y, Furuta K, Takeuchi H, Tajima H, Tominaga H, Satomura H, Kato H, Morita S, Tanada A, Hara T, Kawada M, Sato Y, Takahashi M, Higuchi A, Nakajima T, Wakamatsu Y, Toyokawa M, Ueda A, Roberts P, Miyajima F, Shibayama K.
- Journal Title
  
  J Med Microbiol.
  
  Volume: 64 Issue: 10 Pages: 1226-1236
- DOI
  10.1099/jmm.0.000149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860327
[Journal Article] A factor converting viable but nonculturable Vibrio cholerae to a culturable state in eukaryotic cells is a human catalase2015
- Author(s)
  Senoh M, Hamabata T, Takeda Y
- Journal Title
  
  MicrobiologyOpen
  
  Volume: 4 Issue: 4 Pages: 589-596
- DOI
  10.1002/mbo3.264
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460543
[Journal Article] Reverse transcription polymerase chain reaction-based method for selectively detecting vegetative cells of toxigenic Clostridium difficile.2014
- Author(s)
  Senoh M, Kato H, Murase T, Hagiya H, Tagashira Y, Fukuda T, Iwaki M, Yamamoto A, Shibayama K.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 58 Issue: 11 Pages: 615-620
- DOI
  10.1111/1348-0421.12189
- NAID
  40020271468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860327
[Journal Article] Fulminant pseudomembranous colitis caused by Clostridium difficile PCR ribotype 027 in a healthy young woman in Japan.2014
- Author(s)
  Nishimura S, Kou T, Kato H, Watanabe M, Uno S, Senoh M, Fukuda T, Hata A, Yazumi S.
- Journal Title
  
  J Infect Chemother.
  
  Volume: 20 Issue: 11 Pages: 729-731
- DOI
  10.1016/j.jiac.2014.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860327
[Journal Article] Postoperative Clostridium difficile infection with PCR ribotype 078 strain identified at necropsy in five Thoroughbred racehorses.2013
- Author(s)
  Niwa H, Kato H, Hobo S, Kinoshita Y, Ueno T, Katayama Y, Hariu K, Oku K, Senoh M, Kuroda T, Nakai K.
- Journal Title
  
  Vet Rec
  
  Volume: 173 Issue: 24 Pages: 607-607
- DOI
  10.1136/vr.101960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860327
[Journal Article] Two cases of fulminant colitis due to binary toxin-positive Clostridium difficile that are not PCR ribotype 027 or type 078.2013
- Author(s)
  Tagashira Y, Kato H, Senoh M, Nakamura A.
- Journal Title
  
  J Med Microbiol
  
  Volume: 62 Issue: 9 Pages: 1486-1489
- DOI
  10.1099/jmm.0.057968-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] Gene expression analysis during the conversion from a VBNC to culturable state in Vibrio cholerae2023
- Author(s)
  Alafate Ayibieke、西山紋惠、妹尾充敏、濱端崇
- Organizer
  第57回日米医学協力委員会コレラ・細菌性腸管感染症部会日米合同会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07064
[Presentation] Gene expression analysis during the conversion from a VBNC to culturable state in Vibrio cholerae2023
- Author(s)
  Alafate Ayibieke, 西山紋恵, 妹尾充敏, 濱端崇
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K07064
[Presentation] Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B2020
- Author(s)
  Sakaguchi, Y., Hosomi, K., Kohda, T., Umeda, K., Uchiyama, J., Take, A., Goto, K., Senoh, M., Hayashi, S., Kozaki, S., Mukamoto, M.
- Organizer
  ASM microbe 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07560
[Presentation] Clostridioides difficile感染症患者に対する糞便微生物移植の効果～ヒト腸内微生物叢およびメタボロームの解析～2019
- Author(s)
  阪口義彦、後藤和義、妹尾充敏、武　晃、内山淳平、尾﨑隼人、城代康貴、林　俊治、大宮直木、加藤はる
- Organizer
  第140年会日本薬学会
- Data Source
  KAKENHI-PROJECT-19K07560
[Presentation] Analysis of gut microbiota and metabolite in Fecal transplantation for Clostridioides difficile infection2019
- Author(s)
  阪口義彦、後藤和義、妹尾充敏、内山淳平、尾﨑隼人、城代康貴、林　俊治、大宮直木、加藤はる
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07560
[Presentation] Analysis of gut microbiota and metabolite in fecal transplantation therapy for Clostridioides difficile infection2019
- Author(s)
  阪口義彦、後藤和義、妹尾充敏、武　晃、内山淳平、尾﨑隼人、城代康貴、林　俊治、大宮直木、加藤はる
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07560
[Presentation] Analysis of gut microbiota and metabolite in Fecal transplantation for Clostridioides difficile infection2019
- Author(s)
  阪口義彦、後藤和義、妹尾充敏、内山淳平、尾﨑隼人、城代康貴、林　俊治、大宮直木、加藤はる
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08785
[Presentation] Clostridium difficile感染症に対するDNAワクチンの開発2018
- Author(s)
  妹尾充敏、加藤はる、柴山恵吾
- Organizer
  第92回日本感染症学会学術講演会第66回日本化学療法学会総会合同学会
- Data Source
  KAKENHI-PROJECT-16K19132
[Presentation] Development of DNA vaccine for Clostridium difficile infection2018
- Author(s)
  妹尾充敏, 加藤はる, 岩城正昭, 柴山恵吾
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19132
[Presentation] 糞便移植治療を行ったクロストリディオイデス（クロストリジウム）・ディフィシル感染症例における腸内微生物叢の解析2018
- Author(s)
  阪口義彦、後藤和義、妹尾充敏、内山淳平、城代康貴、尾﨑隼人、林　俊治、大宮直木、加藤はる
- Organizer
  2018年度第31回北里大学バイオサイエンスフォーラム、第21回北里微生物アカデミー研究集会
- Data Source
  KAKENHI-PROJECT-16K08785
[Presentation] クロストリディオイデス（クロストリジウム）・ディフィシル感染症に対する糞便移植におけるヒト腸内微生物叢解析2018
- Author(s)
  阪口義彦、後藤和義、妹尾充敏、内山淳平、尾﨑隼人、城代康貴、林　俊治、大宮直木、加藤はる
- Organizer
  2018年日本細菌学会関東支部インターラボセミナー、第7回ファージ研究会合同大会
- Data Source
  KAKENHI-PROJECT-16K08785
[Presentation] Clostridium difficile感染症(CDI)ワクチンの開発2017
- Author(s)
  妹尾充敏
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K19132
[Presentation] 膜画分を用いたClostridium difficile感染症(CDI)ワクチンのin vivo効果2016
- Author(s)
  妹尾充敏, 岩城正昭, 山本明彦, 加藤はる, 福田靖, 柴山恵吾
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] Nontoxigenic Clostridium difficile membrane fraction as a vaccine candidate.2015
- Author(s)
  Senoh M, Iwaki M, Yamamoto A, Kato H, Fukuda T, Shibayama K.
- Organizer
  The 6th Congress of European Microbiologists
- Place of Presentation
  Maastricht, Netherlands
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] Prevalence of two PCR ribotypes, smz (180) and trf (369) of Clostridium difficile in JAPAN.2015
- Author(s)
  Kato H, Senoh M, Fukuda T, Roberts P, Miyajima F, Shibayama K.
- Organizer
  5th International Clostridium difficile Symposium
- Place of Presentation
  Bled, Slovenia
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] 日本の医療施設におけるClostridium difficile感染症の疫学調査2014
- Author(s)
  妹尾充敏、加藤はる、福田靖、柴山恵吾
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] 毒素産生性Clostridium difficileの新規遺伝学的検査法の開発
- Author(s)
  妹尾充敏、加藤はる、福田靖、柴山恵吾
- Organizer
  第61回トキシンシンポジウム
- Place of Presentation
  鳴門
- Year and Date
  2014-09-03 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] 毒素産生性Clostridium difficile栄養型菌の新規遺伝学的検査法の開発
- Author(s)
  妹尾充敏、加藤はる、福田靖、柴山恵吾
- Organizer
  第88回日本感染症学会学術講演会　第62回日本化学療法学会総会　合同学会
- Place of Presentation
  博多
- Year and Date
  2014-06-18 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25860327
[Presentation] 膜画分を用いたClostridium difficile感染症(CDI)ワクチンの開発
- Author(s)
  妹尾充敏, 岩城正昭, 山本明彦, 加藤はる, 福田靖, 柴山恵吾
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860327

1. 加藤はる (00273136)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. Sakaguchi Yoshihiko (70403491)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. Hamabata Takashi (40311427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 林俊治 (40260765)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. 大宮直木 (00335035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. 内山淳平 (20574619)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. 後藤和義 (20626593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 村端真由美 (30363956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 矢野久子 (00230285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 内田恵一 (30293781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小池勇樹 (10555551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Senoh Mitsutoshi 妹尾 充敏

Research Projects

Research Products

Co-Researchers

Clostridioides difficile感染症に対する糞便移植療法の治療因子の同定と作用解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on the conversion mechanism from VBNC to culturable in pathogenic bacteria

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

在宅で療養する炎症性腸疾患患児の感染予防のための支援方法の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatment method for Clostridioides difficile infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study for a molecular machinery of the host recognition by Clostridioides difficile phage to develop the advanced therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the molecular machinery of host recognition by the Clostridium botulinum type C and D neurotoxin-converting phages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of DNA vaccine for Clostridium difficile infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the conversion from VBNC to culturable state in Vibrio cholerae

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of vaccine for Clostridium difficile infection using membrane fractionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Gene expression analysis during the conversion from a viable but nonculturable to culturable state in Vibrio cholerae2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of vaccine for Clostridium difficile infection using membrane fraction of nontoxigenic Clostridium difficile2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of adhesion of Clostridium difficile to human intestinal cells after treatment with serum and intestinal fluid isolated from mice immunized with nontoxigenic C. difficile membrane fraction.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predominance of PCR-ribotypes, 018 (smz) and 369 (trf) of Clostridium difficile in Japan: a potential relationship with other global circulating strains?2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A factor converting viable but nonculturable Vibrio cholerae to a culturable state in eukaryotic cells is a human catalase2015

Author(s)

Senoh Mitsutoshi 妹尾充敏