MANO TATSUO 間野達雄

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Mano Tatsuo 間野達雄

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Researcher Number	20704331
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 2017 – 2021: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 神経細胞 / DNA傷害 / アルツハイマー病 / マウスモデル / 血管リスク / 動脈硬化 / 神経変性疾患 / 慢性虚血 / エピゲノム / パーキンソン病 … More / 興奮性活動 / 加齢 / DNA障害 / 脳神経疾患 / 三次元培養 / 細胞モデル / 剖検脳 / リン酸化タウ / アミロイドβ / ３次元細胞培養系 … More Except Principal Investigator cellular network / intranuclear inclusion / GGCリピート長 / フローサイトメトリー / 単一細胞RNA-seq / 神経細胞核内封入体病 Less

Disorders of intercellular communication centered on nuclear inclusion bodies in neurodegenerative diseases.
- Principal Investigator
  
  岩田淳
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
パーキンソン病における慢性脳低灌流のエピジェネティック制御を介した神経保護効果Principal Investigator
- Principal Investigator
  
  間野達雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Center of Neurology and Psychiatry
Maintenance of genomic integrity in neuronal cellsPrincipal Investigator
- Principal Investigator
  
  Mano Tatsuo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Tokyo
A novel model for DNA damageaccumulation in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Mano Tatsuo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 Other

All Journal Article Presentation Book Other

[Book] 医学のあゆみ　アルツハイマー病―研究と治療の最前線2023
- Author(s)
  間野達雄、岩田淳
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-22K07512
[Book] Exosomeと疾患アルツハイマー病2022
- Author(s)
  間野達雄, 岩田淳
- Total Pages
  3
- Publisher
  Clinical Neuroscience
- Data Source
  KAKENHI-PROJECT-22K07512
[Book] Autophagy dysfunction in Alzheimer’s disease and dementia2022
- Author(s)
  Tatsuo Mano, Atsushi Iwata
- Total Pages
  16
- Publisher
  Academic press,
- Data Source
  KAKENHI-PROJECT-22K07512
[Book] 加齢脳とエピジェネティクス異常2022
- Author(s)
  間野達雄, 岩田淳
- Total Pages
  6
- Publisher
  老年精神医学雑誌
- Data Source
  KAKENHI-PROJECT-22K07512
[Book] Clinical Neuroscience【脳神経-もう一度眺めてみよう】特徴的症候群A to Z Parinaud症候群2021
- Author(s)
  間野達雄、岩田淳
- Total Pages
  2
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19K17027
[Book] Clinical Neuroscience【動的ヘテラルキー-脳は階層固定的か?】各論ヘテラルキーからみた神経疾患と治療エピゲノム2021
- Author(s)
  間野達雄、岩田淳
- Total Pages
  4
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19K17027
[Book] 医学のあゆみ：神経変性におけるDNAメチル化2018
- Author(s)
  間野かがり，間野達雄，岩田淳
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17K16113
[Book] 医学のあゆみ：アルツハイマー病のエピジェネティクス2018
- Author(s)
  間野達雄, 岩田淳
- Total Pages
  3
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17K16113
[Book] 実験医学：Current topics 神経細胞特異的メチル化解析から明らかになったアルツハイマー病におけるDNA修復の障害2018
- Author(s)
  間野達雄, 岩田淳
- Total Pages
  2
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17K16113
[Book] 実験医学増刊：認知症のエピジェネティクス2017
- Author(s)
  間野達雄, 岩田淳
- Total Pages
  2
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17K16113
[Journal Article] Anti-neurofascin 155 Antibody-positive Neuropathy in a Human Immunodeficiency Virus-infected Patient2024
- Author(s)
  So Okubo, Tatsuo Mano, Atsushi Sudo, Ryoji Goto, Satoka Yano, Manato Hara, Hiroyuki Ishiura, Wataru Satake, Shintaro Yanagimoto, Hidenori Ogata, Tatsushi Toda
- Journal Title
  
  Intern. Med.
  
  Volume: 63 Issue: 4 Pages: 565-569
- DOI
  10.2169/internalmedicine.1919-23
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2024-02-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07512
[Journal Article] Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease2023
- Author(s)
  Kurihara Masanori、Mano Tatsuo、Eto Fumihiro、Yao Ikuko、Sato Kenichiro、Ohtomo Gaku、Bannai Taro、Shibata Shota、Ishiura Hiroyuki、Ikemura Masako、Matsubara Tomoyasu、Morishima Maho、Saito Yuko、Murayama Shigeo、Toda Tatsushi、Setou Mitsutoshi、Iwata Atsushi
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 177 Pages: 105989-105989
- DOI
  10.1016/j.nbd.2023.105989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07512, KAKENHI-PROJECT-22K15740, KAKENHI-PROJECT-20H03588, KAKENHI-PROJECT-21K20891, KAKENHI-PROJECT-23K24055, KAKENHI-PROJECT-23K18267, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-20H03587
[Journal Article] Photo‐oxygenation of histidine residue inhibits α‐synuclein aggregation2023
- Author(s)
  Nakamura Reito、Tomizawa Ikumi、Iwai Atsushi、Ikeda Tetsuo、Hirayama Kota、Chiu Yung Wen、Suzuki Takanobu、Tarutani Airi、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi、Sohma Youhei、Kanai Motomu、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 12
- DOI
  10.1096/fj.202301533r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0133, KAKENHI-PROJECT-22K07512, KAKENHI-ORGANIZER-22H05035, KAKENHI-PROJECT-23H00394, KAKENHI-PROJECT-20H03587, KAKENHI-PROJECT-21H02602, KAKENHI-PROJECT-23K21357
[Journal Article] Time to onset of drug-induced parkinsonism: Analysis using a large Japanese adverse event self-reporting database2022
- Author(s)
  Sato Kenichiro、Niimi Yoshiki、Mano Tatsuo、Iwata Atsushi、Iwatsubo Takeshi
- Journal Title
  
  BioScience Trends
  
  Volume: 16 Issue: 2 Pages: 151-157
- DOI
  10.5582/bst.2022.01115
- ISSN
  1881-7815, 1881-7823
- Year and Date
  2022-04-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07512, KAKENHI-PROJECT-21K20891
[Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain.2022
- Author(s)
  Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 31 Issue: 1 Pages: 122-132
- DOI
  10.1093/hmg/ddab226
- NAID
  120007186913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03587, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-16H06277
[Journal Article] Peripheral Blood BRCA1 Methylation Positively Correlates with Major Alzheimer’s Disease Risk Factors2021
- Author(s)
  Mano T.、Sato K.、Ikeuchi T.、Toda T.、Iwatsubo T.、Iwata A.
- Journal Title
  
  The Journal of Prevention of Alzheimer's Disease
  
  Volume: 8 Issue: 4 Pages: 1-6
- DOI
  10.14283/jpad.2021.31
- Data Source
  KAKENHI-PROJECT-19K17027
[Journal Article] Neuron-specific analysis of histone modifications with post-mortem brains2020
- Author(s)
  Koshi-Mano Kagari、Mano Tatsuo、Morishima Maho、Murayama Shigeo、Tamaoka Akira、Tsuji Shoji、Toda Tatsushi、Iwata Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 3767-3767
- DOI
  10.1038/s41598-020-60775-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-16H06277
[Journal Article] Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database2020
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi
- Journal Title
  
  BioScience Trends
  
  Volume: 14 Issue: 2 Pages: 139-143
- DOI
  10.5582/bst.2020.03082
- NAID
  130007845360
- ISSN
  1881-7815, 1881-7823
- Year and Date
  2020-04-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-20J11009, KAKENHI-PROJECT-18H01085
[Journal Article] Autocorrelation-based method to identify disordered rhythm in Parkinson’s disease tasks: A novel approach applicable to multimodal devices2020
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 10 Pages: 0238486-0238486
- DOI
  10.1371/journal.pone.0238486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-20J11009
[Journal Article] Attempt to Predict A/T/N-Based Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Using a Peripheral Blood DNA Methylation Clock2020
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Suzuki Kazushi、Toda Tatsushi、Iwatsubo Takeshi、Iwata Atsushi、for Alzheimer’s Disease Neuroimaging Initiative
- Journal Title
  
  Journal of Alzheimer's Disease Reports
  
  Volume: 4 Issue: 1 Pages: 287-296
- DOI
  10.3233/adr-200205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-20J11009
[Journal Article] Isolated Body Lateropulsion in Supplementary Motor Area Infarction2020
- Author(s)
  Ueda Kunihiro、Seto Akiko、Mano Tatsuo、Toda Tatsushi
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 23 Pages: 3113-3114
- DOI
  10.2169/internalmedicine.5320-20
- NAID
  130007948779
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17027
[Journal Article] Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies2019
- Author(s)
  Kurihara Masanori、Mano Tatsuo、Saito Yuko、Murayama Shigeo、Toda Tatsushi、Iwata Atsushi
- Journal Title
  
  Brain Sciences
  
  Volume: 10 Issue: 1 Pages: 7-7
- DOI
  10.3390/brainsci10010007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-19J10924, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03587
[Journal Article] Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer’s Disease in the Japanese Alzheimer’s Disease Neuroimaging Initiative2019
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Ihara Ryoko、Suzuki Kazushi、et al.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 68 Issue: 2 Pages: 777-788
- DOI
  10.3233/jad-181115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09794, KAKENHI-PROJECT-17K16113
[Journal Article] Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease2019
- Author(s)
  Ishiura Hiroyuki、Shibata Shota、Yoshimura Jun、Suzuki YutaMano Tatsuo、Iwata Atsushi、Toda Tatsushi、Morishita Shinichi、Tsuji Shoji、et al
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 8 Pages: 1222-1232
- DOI
  10.1038/s41588-019-0458-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-17H05085, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H00597
[Journal Article] Neurological and related adverse events in immune checkpoint inhibitors: a pharmacovigilance study from the Japanese Adverse Drug Event Report database2019
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi
- Journal Title
  
  Journal of Neurooncology
  
  Volume: 1 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17027
[Journal Article] Quantifying normal and parkinsonian gait features from home movies: Practical application of a deep learning?based 2D pose estimator2019
- Author(s)
  Sato Kenichiro、Nagashima Yu、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 11 Pages: 0223549-0223549
- DOI
  10.1371/journal.pone.0223549
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PUBLICLY-18H04729
[Journal Article] Estimating acceleration time point of respiratory decline in ALS patients: A novel metric2019
- Author(s)
  Sato Kenichiro、Iwata Atsushi、Kurihara Masanori、Nagashima Yu、Mano Tatsuo、Toda Tatsushi
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 403 Pages: 7-12
- DOI
  10.1016/j.jns.2019.05.031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PUBLICLY-18H04729, KAKENHI-PROJECT-19J10924
[Journal Article] Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight2019
- Author(s)
  Bannai Taro、Mano Tatsuo、Chen Xigui、Ohtomo Gaku、Ohtomo Ryo、Tsuchida Takeyuki、Koshi-Mano Kagari、Hashimoto Tadafumi、Okazawa Hitoshi、Iwatsubo Takeshi、Tsuji Shoji、Toda Tatsushi、Iwata Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2827-2827
- DOI
  10.1038/s41598-019-39494-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-16H02655
[Journal Article] Subtype‐Dependent Reporting of Stroke With SGLT2 Inhibitors: Implications From a Japanese Pharmacovigilance Study2019
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi
- Journal Title
  
  The Journal of Clinical Pharmacology
  
  Volume: 60 Issue: 5 Pages: 629-635
- DOI
  10.1002/jcph.1561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17027
[Journal Article] Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis2019
- Author(s)
  Sato Kenichiro、Mano Tatsuo、Matsuda Hiroshi、Senda Michio、Ihara Ryoko、Suzuki Kazushi、Arai Hiroyuki、Ishii Kenji、Ito Kengo、Ikeuchi Takeshi、Kuwano Ryozo、Toda Tatsushi、Iwatsubo Takeshi、Iwata Atsushi
- Journal Title
  
  NeuroImage: Clinical
  
  Volume: 24 Pages: 101957-101957
- DOI
  10.1016/j.nicl.2019.101957
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-17K09794
[Journal Article] Isolated unilateral ptosis due to midbrain infarction2018
- Author(s)
  Kurihara Masanori、Mano Tatsuo、Arakawa Akira、Iwata Atsushi、Toda Tatsushi
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: 6 Issue: 6 Pages: 199-199
- DOI
  10.1111/ncn3.12227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16113
[Journal Article] Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons2018
- Author(s)
  Tsuchida Takeyuki、Mano Tatsuo、Koshi-Mano Kagari、Bannai Taro、Matsubara Tomoyasu、Yamashita Satoshi、Ushijima Toshikazu、Nagata Kenichi、Murayama Shigeo、Toda Tatsushi、Tsuji Shoji、Iwata Atsushi
- Journal Title
  
  Brain Research
  
  Volume: 1697 Pages: 59-66
- DOI
  10.1016/j.brainres.2018.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-16H06277
[Journal Article] DNA methylation level of the neprilysin promoter in Alzheimer's disease brains2018
- Author(s)
  Nagata Kenichi、Mano Tatsuo、Murayama Shigeo、Saido Takaomi C.、Iwata Atsushi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 670 Pages: 8-13
- DOI
  10.1016/j.neulet.2018.01.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-16H05319
[Journal Article] Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction2018
- Author(s)
  Ohtomo Gaku、Mano Tatsuo、Seto Akiko、Tsuji Shoji
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 5 Pages: 767-768
- DOI
  10.2169/internalmedicine.9442-17
- NAID
  130006407707
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16113
[Journal Article] An Autopsy Case of Familial Neuronal Intranuclear Inclusion Disease with Dementia and Neuropathy2018
- Author(s)
  Yamaguchi Nanaka、Mano Tatsuo、Ohtomo Ryo、Ishiura Hiroyuki、Almansour M. Asem、Mori Harushi、Kanda Junko、Shirota Yuichiro、Taira Kenichiro、Morikawa Teppei、Ikemura Masako、Yanagi Yasuo、Murayama Shigeo、Shimizu Jun、Sakurai Yasuhisa、Tsuji Shoji、Iwata Atsushi
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 23 Pages: 3459-3462
- DOI
  10.2169/internalmedicine.1141-18
- NAID
  130007539687
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2018-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-17H05085
[Journal Article] Case of a 78-year-old woman with a neuronal intranuclear inclusion disease.2017
- Author(s)
  Takumida H, Yakabe M, Mori H, Shibasaki K, Umeda-Kameyama Y, Urano T, Mano T, Hayashi A, Ikemura M, Ogawa S, Akishita M.
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 17 Issue: 12 Pages: 2623-2625
- DOI
  10.1111/ggi.13174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09796, KAKENHI-PROJECT-17K15889, KAKENHI-PROJECT-17K16113
[Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease2017
- Author(s)
  Mano Tatsuo、Nagata Kenichi、Nonaka Takashi、Tarutani Airi、Imamura Tomohiro、Hashimoto Tadafumi、Bannai Taro、Koshi-Mano Kagari、Tsuchida Takeyuki、Ohtomo Ryo、Takahashi-Fujigasaki Junko、Yamashita Satoshi、Ohyagi Yasumasa、Yamasaki Ryo、Tsuji Shoji、Tamaoka Akira、et al.
- Journal Title
  
  Proc Natl Acad Sci U.S.A.
  
  Volume: 114 Issue: 45
- DOI
  10.1073/pnas.1707151114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-17K16113, KAKENHI-PUBLICLY-17H05687, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Presentation] パーキンソン病における神経細胞特異的エピゲノム2023
- Author(s)
  間野達雄 , 大友岳 , 橋本唯史 , 戸田達史 , 岩田淳
- Organizer
  認知症学会
- Data Source
  KAKENHI-PROJECT-22K07512
[Presentation] Cell-type specific histone modification in the brain.2022
- Author(s)
  間野達雄、橋本唯史
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-22K07512
[Presentation] HIF1α依存性オートファジーによるαシヌクレイン病理の分解促進2021
- Author(s)
  大友岳，間野達雄，岩田淳，戸田達史
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17027
[Presentation] HIF1A-dependent autophagy mitigates alpha-synuclein pathology and cognitive impairment2021
- Author(s)
  間野達雄，大友岳，岩田淳，戸田達史
- Organizer
  日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17027
[Presentation] 低酸素誘導因子HIF1A依存的オートファジーはαシヌクレイン病理を改善させる2021
- Author(s)
  間野達雄，大友岳，岩田淳，戸田達史
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K17027
[Presentation] Epigenetic approach to Alzheimer's disease2020
- Author(s)
  間野　達雄、岩田淳
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17027
[Presentation] アルツハイマー病に対する神経細胞特異的なエピゲノムアプローチ2019
- Author(s)
  間野　達雄
- Organizer
  日本人類遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17027
[Presentation] 慢性脳低灌流が脳内アミロイドβ蛋白の動態に及ぼす影響　APP/PS1マウスを用いた病理学的検討2018
- Author(s)
  坂内太郎、大友亮、大友岳、間野達雄、岩田淳
- Organizer
  第43回日本脳卒中学会
- Data Source
  KAKENHI-PROJECT-17K16113
[Presentation] Utility of ferroxidase activity assay in the diagnosis of aceruloplasminemia with detectable serum ceruloplasmin levels2017
- Author(s)
  Rimi Inoue, Tatsuo Mano, Aki Mitsue, Masaki Tanaka, Takashi Matsukawa, Jun Mitsui, Atsushi Iwata1, Toshihiro Hayashi, Shoji Tsuji
- Organizer
  WCN2017(World Congress of Neurology 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16113
[Presentation] Analysis of neuron-specific histone modifications2017
- Author(s)
  Kagari Koshi-Mano, Tatsuo Mano, Atsushi Iwata
- Organizer
  WCN2017(World Congress of Neurology 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16113
[Presentation] Chronic cerebral hypoperfusion accelerates amyloid beta deposits in app/ps1 transgenic mice2017
- Author(s)
  Taro Bannai, Ryo Ohtomo, Tatsuo Mano, Shoji Tsuji, Atsushi Iwata
- Organizer
  WCN2017(World Congress of Neurology 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16113
[Presentation] In vitro AD model using human neural progenitor cell2017
- Author(s)
  Tatsuo Mano, Atsushi Iwata
- Organizer
  WCN2017(World Congress of Neurology 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16113
[]
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1. 岩田淳 (40401038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 浦野友彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 鈴木一詩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 橋本唯史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 富田泰輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 堀由起子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 金井求

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 玉岡晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 西村正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MANO TATSUO 間野 達雄

Mano Tatsuo 間野 達雄

Research Projects

Research Products

Co-Researchers

Disorders of intercellular communication centered on nuclear inclusion bodies in neurodegenerative diseases.

Principal Investigator

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パーキンソン病における慢性脳低灌流のエピジェネティック制御を介した神経保護効果Principal Investigator

Principal Investigator

Project Period (FY)

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Maintenance of genomic integrity in neuronal cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

A novel model for DNA damageaccumulation in Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Book] 医学のあゆみ アルツハイマー病―研究と治療の最前線2023

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[Book] Exosomeと疾患 アルツハイマー病2022

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[Book] Autophagy dysfunction in Alzheimer’s disease and dementia2022

Author(s)

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[Book] 加齢脳とエピジェネティクス異常2022

Author(s)

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[Book] Clinical Neuroscience【脳神経-もう一度眺めてみよう】特徴的症候群A to Z Parinaud症候群2021

Author(s)

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[Book] Clinical Neuroscience【動的ヘテラルキー-脳は階層固定的か?】各論 ヘテラルキーからみた神経疾患と治療 エピゲノム2021

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[Book] 医学のあゆみ：神経変性におけるDNAメチル化2018

Author(s)

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[Book] 医学のあゆみ：アルツハイマー病のエピジェネティクス2018

Author(s)

Total Pages

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Data Source

[Book] 実験医学：Current topics 神経細胞特異的メチル化解析から明らかになったアルツハイマー病におけるDNA修復の障害2018

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[Book] 実験医学増刊：認知症のエピジェネティクス2017

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[Journal Article] Anti-neurofascin 155 Antibody-positive Neuropathy in a Human Immunodeficiency Virus-infected Patient2024

MANO TATSUO 間野達雄

Mano Tatsuo 間野達雄

[Book] 医学のあゆみ　アルツハイマー病―研究と治療の最前線2023

[Book] Exosomeと疾患アルツハイマー病2022

[Book] Clinical Neuroscience【動的ヘテラルキー-脳は階層固定的か?】各論ヘテラルキーからみた神経疾患と治療エピゲノム2021