Sakaue Tomohisa 坂上倫久

Researcher Number	20709266
Other IDs	https://orcid.org/0000-0001-7724-2225
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 講師(特定教員)
Affiliation (based on the past Project Information) *help	2019 – 2024: 愛媛大学, 医学系研究科, 講師(特定教員) 2016 – 2018: 愛媛大学, 医学系研究科, 助教(特定教員) 2017: 愛媛大学, 大学院・医学系研究科, 助教 2015: 愛媛大学, 医学(系)研究科(研究院), 助教(特定教員) 2014: 愛媛大学, 学内共同利用施設等, その他 2013 – 2014: 愛媛大学, プロテオサイエンスセンター, 助教(特命教員)
Review Section/Research Field	Principal Investigator Tumor biology / Basic Section 55030:Cardiovascular surgery-related / Basic Section 50010:Tumor biology-related / General medical chemistry Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 55030:Cardiovascular surgery-related / Basic Section 53020:Cardiology-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Respiratory surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related … More / Basic Section 50010:Tumor biology-related / Basic Section 90120:Biomaterials-related / Basic Section 52050:Embryonic medicine and pediatrics-related / General medical chemistry / Cardiovascular surgery Less
Keywords	Principal Investigator 血管内皮細胞 / CUL3 / ユビキチン / 血管新生 / KCTD / アクチン / 細胞骨格 / 細胞運動 / トランスレーショナルリサーチ / シングルセル … More / 弁膜症 / 心血管 / トランスクリプトミクス / 間質細胞 / 石灰化 / 心臓 / 骨芽細胞 / 大動脈弁 / 心血管系 / アクチン骨格 / E3ユビキチンリガーゼ / タンパク質分解 / AlphaScreen / 基質 / 網膜 / 心疾患 / がん / ユビキチンリガーゼ / アクチン重合 / Rho / angiogenesis / BTB / VEGFR2 … More Except Principal Investigator 虚血再灌流障害 / 血管内皮細胞 / 肺移植 / 石灰化 / 大動脈弁狭窄症 / 肺癌 / 弁膜症 / ユビキチンリガーゼ / 血管新生 / PD-L1 / AS / 大動脈弁 / CRL3 / 骨芽細胞 / CUL3 / 免疫チェックポイント / Nedd8 / 免疫チェックポイント阻害剤 / 翻訳後修飾 / NEDD8 / 心停止ドナーからの肺移植 / バイオマーカー / HB-EGF / 線維化 / 弁間質細胞 / 間質細胞 / アンギオプロテオスタシス / 腫瘍血管 / 腸管慢性炎症発がん / cullin3 / E3ユビキチンリガーゼ / 腸管慢性炎症 / 血管 / 癒着 / 呼吸器外科手術 / 胸腔内癒着 / 心膜癒着 / NETs / インフラマゾーム形成阻害剤 / シングルセルRNA-seq解析 / NLRP3型インフラマゾーム / 心膜癒着形成 / 腫瘍微小環境 / 免疫療法 / トランスクリプトーム / 動物モデル / 心臓弁 / 抗石灰化 / シルクフィブロイン / 空間解析 / 拒絶反応 / 心血管疾患 / 生体医用材料 / プロテオスタシス / KCTD10 / 髄芽腫 / 心血管障害 / 尿毒症物質 / 腎不全 / 細胞骨格 / 心肥大 / インドキシル硫酸 / 脂質 / リン脂質 / 脂質代謝 / プロスタグランジン / Neddylation / 肺癌細胞 / 免疫チェックポイント阻害 / 転写 / 癌免疫チェックポイント / 免疫回避機構 / 癌免疫チェックポイント阻害剤 / 肺がん / S100 / 抗S100A8/A9中和抗体 / S100A9 / S100A8 / 循環器科 / 生体吸収性素材 / 心房中隔欠損孔閉鎖デバイス / 心臓血管外科 / 経カテーテル的 / 動物実験 / 心房中隔欠損孔閉鎖デバイ / 生体吸収性 / Biodegradable Material / Occluder / ASD / 医療デバイス / 心房中隔欠損症 / 生体分解性素材 / 心血管 / トランスレーショナルリサーチ / モデルマウス / 虚血再灌流 / 酸化ストレス / Cullin-3 / 疾患バイオマーカー / 病態進行鍵分子 / 臨床検体(手術・血液・剖検サンプル) / 創薬・化合物ライブラリー / 質量分析 / 二次元電気泳動 / 網羅解析 / 小児心臓手術 / 先天性心疾患 / 心臓癒着防止 / 心膜再生 / 生体親和性ナノ複合代用心膜 / MPCコーティング / iBTA / 焼成PTFE / PTFE / バイオシート / ポリ乳酸 / ナノ複合 / 自己心膜 / ユビキチンE3リガーゼ / Integrin β1 / 細胞内膜輸送 / Cullin / タンパク質代謝 / 癌免疫 / 腫瘍免疫 / 虚血再灌流霜害 / 心臓 / VIC Less

心臓血管外科治療で用いる生体材料の石灰化メカニズムの包括的理解
- Principal Investigator
  
  泉谷裕則
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
時空間的解析による心停止ドナーからの肺移植の包括的病態解明と新規治療法の開発
- Principal Investigator
  
  岡崎幹生
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
High Functionalization of Silk Fibroin for Cardiovascular Devices and Its Application to Novel Artificial Heart Valves
- Principal Investigator
  
  中澤靖元
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo University of Agriculture and Technology
動物モデルを用いた大動脈弁狭窄症の発症から重症化までの包括的理解
- Principal Investigator
  
  坂本裕司
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
細胞内mRNA代謝に着目した肺癌細胞免疫回避機構の解明
- Principal Investigator
  
  坂尾伸彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Ehime University
肺癌微小環境を構築する間質細胞を標的とした新たな肺癌治療戦略
- Principal Investigator
  
  桐山洋介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Ehime University
Neutrophil extracellular trapsを介した心膜癒着メカニズムの解明とその制御法の開発
- Principal Investigator
  
  薦田宗則
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
転写制御因子を標的とした新規肺虚血再灌流障害制御法の開発と臨床応用
- Principal Investigator
  
  大谷真二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Ehime University
胸膜癒着の機序解明とその制御法の開発
- Principal Investigator
  
  藻利優
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Ehime University
Studies of medulloblastoma associating angiogenesis based on CRL3
- Principal Investigator
  
  田手壮太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Ehime University
Understanding the molecular mechanism of aortic valve calcification at the single-cell levelPrincipal Investigator
- Principal Investigator
  
  坂上倫久
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
腸管慢性炎症からがんの発症・進展を誘導する血管リモデリングの解明
- Principal Investigator
  
  渡部祐司
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ehime University
Pathophysiology of Cardiovascular Injury Caused by Uremic Toxins Focusing on Cytoskeletal Regulation
- Principal Investigator
  
  Makita Ayu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
Investigation of Tissue Regeneration after Transplantation of Transcatheter Atrial Septal Closure Using Bioabsorbable Material
- Principal Investigator
  
  Kurobe Hirotsugu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
Elucidation of the role of S100A8/A9 in pulmonary ischemia-reperfusion injury and development of new therapeutic strategies
- Principal Investigator
  
  Okazaki Mikio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Elucidation of a Novel Mechanism Regulating PD-L1 Expression in Lung Cancer and Its Role in Immune Evasion
- Principal Investigator
  
  Sano Yoshifumi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Ehime University
Novel lipid metabolic signaling regulating ectopic osteoblast differentiation in the aortic valve.
- Principal Investigator
  
  Izutani Hironori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Ehime University
心停止ドナーからの肺移植後虚血再灌流障害のトランスレーショナルリサーチと治療応用
- Principal Investigator
  
  岡崎幹生
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
Investigation of molecular mechanisms and predictive blood biomarkers in aortic valve stenosis using human clinical specimens
- Principal Investigator
  
  Aono Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
Development of therapy of pulmonary ischemia-reperfusion injury targeting ubiquitin ligase
- Principal Investigator
  
  杉本龍士郎
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Ehime University
Identification of master regulator of osteoblast differentiation in valve calcification
- Principal Investigator
  
  Izutani Hironori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
Analysis of novel CUL3 complex-mediated angiogenesis regulatory pathwayPrincipal Investigator
- Principal Investigator
  
  Sakaue Tomohisa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Ehime University
Development of pericardial regeneration materials and treatment using biocompatible nanocomposite pericardial substitutes in congenital heart surgery
- Principal Investigator
  
  Uchita Shunji
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
Inhibition of lung ischemia reperfusion injury by R-Spondin 3
- Principal Investigator
  
  Okazaki Mikio
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
  Ehime University
Analysis of molecular mechanism of NEDD8-mediated regulation of PD-L1 in lung cancer
- Principal Investigator
  
  Yoshifumi Sano
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Ehime University
Elucidation of molecular mechanism and development of novel diagnostic methods for aortic valve stenosis
- Principal Investigator
  
  Hironori Izutani
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Ehime University
Functional analysis of KCTD protein as a novel angiogenic regulatorPrincipal Investigator
- Principal Investigator
  
  Sakaue Tomohisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Ehime University
Molecular basis of angiogenesis regulated by CUL3-dependent membrane trafficking
- Principal Investigator
  
  Maekawa Masashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Ehime University
Analysis of the spatio-temporal angiogenic regulation by CUL3Principal Investigator
- Principal Investigator
  
  Sakaue Tomohisa
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Ehime University
E3ユビキチンリガーゼCUL3による血管新生制御機構の解析Principal Investigator
- Principal Investigator
  
  坂上倫久
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Ehime University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] 大動脈弁狭窄症の病態解明とその治療法の開発研究2018
- Author(s)
  坂上倫久、中岡裕智、青野潤、倉田美恵、東山繁樹、泉谷裕則
- Total Pages
  43
- Publisher
  愛媛医学 37(1): 01-04
- Data Source
  KAKENHI-PROJECT-16K10631
[Book] 月刊「細胞」2018年 11月号2018
- Author(s)
  坂上倫久、前川大志、藤崎亜耶子、中山寛尚、泉谷裕則、東山繁樹
- Total Pages
  44
- Publisher
  ニュー・サイエンス社
- Data Source
  KAKENHI-PROJECT-18K07234
[Journal Article] Bioprosthetic Valve Deterioration: Accumulation of Circulating Proteins and Macrophages in the Valve Interstitium2023
- Author(s)
  Sakaue Tomohisa、Koyama Tadaaki、Nakamura Yoshitsugu、Okamoto Keitaro、Kawashima Takayuki、Umeno Tadashi、Nakayama Yasuhide、Miyamoto Shinji、Shikata Fumiaki、Hamaguchi Mika、Aono Jun、Kurata Mie、Namiguchi Kenji、Uchita Shunji、Masumoto Junya、Yamaguchi Osamu、Higashiyama Shigeki、Izutani Hironori
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 8 Issue: 7 Pages: 862-880
- DOI
  10.1016/j.jacbts.2023.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19438, KAKENHI-PROJECT-23K24418, KAKENHI-PROJECT-23K27635
[Journal Article] 生体分解性素材を用いた医療デバイスの開発2023
- Author(s)
  黒部裕嗣，新岡俊治，平田陽一郎，福西琢真，森谷友造, 倉田美恵，坂上倫久，檜垣高史，泉谷裕則
- Journal Title
  
  愛媛医学
  
  Volume: 42 Pages: 119-126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09129
[Journal Article] Reply2023
- Author(s)
  Sakaue Tomohisa、Izutani Hironori
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 8 Issue: 11 Pages: 1476-1476
- DOI
  10.1016/j.jacbts.2023.09.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24418
[Journal Article] Functional Blockage of S100A8/A9 Ameliorates Ischemia Reperfusion Injury in the Lung2022
- Author(s)
  Nakata Kentaro、Okazaki Mikio、Sakaue Tomohisa、Kinoshita Rie、Komoda Yuhei、Shimizu Dai、Yamamoto Haruchika、Tanaka Shin、Suzawa Ken、Shien Kazuhiko、Miyoshi Kentaroh、Yamamoto Hiromasa、Ohara Toshiaki、Sugimoto Seiichiro、Yamane Masaomi、Matsukawa Akihiro、Sakaguchi Masakiyo、Toyooka Shinichi
- Journal Title
  
  Bioengineering
  
  Volume: 9 Issue: 11 Pages: 673-673
- DOI
  10.3390/bioengineering9110673
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09164, KAKENHI-PROJECT-20KK0203, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-20K07636, KAKENHI-PROJECT-22H04923
[Journal Article] Pathological Evidence of Native Aortic Valve Injury After Impella Support2021
- Author(s)
  Higashi Haruhiko、Nishimura Takashi、Aono Jun、Sakaue Tomohisa、Kurata Mie、Izutani Hironori、Yamaguchi Osamu
- Journal Title
  
  Circulation: Heart Failure
  
  Volume: 14 Issue: 2
- DOI
  10.1161/circheartfailure.120.007571
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08585, KAKENHI-PROJECT-19H03740, KAKENHI-PROJECT-20K07376
[Journal Article] Active aneurysm thrombosis after Kawasaki disease in an adult: Insight into anticoagulation therapy2021
- Author(s)
  Akazawa Yusuke、Inaba Shinji、Sakaue Tomohisa、Kurata Mie、Aono Jun、Yasugi Takumi、Moritani Tomozo、Nishiyama Hikaru、Higaki Takashi、Eguchi Mariko、Yamaguchi Osamu
- Journal Title
  
  Journal of Cardiology Cases
  
  Volume: 23 Issue: 5 Pages: 206-209
- DOI
  10.1016/j.jccase.2020.11.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03740, KAKENHI-PROJECT-20K07376
[Journal Article] Hypoxic Culture Maintains Cell Growth of the Primary Human Valve Interstitial Cells with Stemness2021
- Author(s)
  Kanno Kaho、Sakaue Tomohisa、Hamaguchi Mika、Namiguchi Kenji、Nanba Daisuke、Aono Jun、Kurata Mie、Masumoto Junya、Higashiyama Shigeki、Izutani Hironori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 19 Pages: 10534-10534
- DOI
  10.3390/ijms221910534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03740, KAKENHI-PROJECT-20K07376, KAKENHI-PROJECT-20K21632
[Journal Article] Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.2019
- Author(s)
  Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M, Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H.
- Journal Title
  
  Ann Thorac Surg.
  
  Volume: 19 Pages: 31717-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03740
[Journal Article] Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.2019
- Author(s)
  Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M,?Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H.
- Journal Title
  
  Ann Thorac Surg
  
  Volume: S0003-4975 Issue: 1 Pages: 31717-5
- DOI
  10.1016/j.athoracsur.2019.09.085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04954, KAKENHI-PUBLICLY-19H05418, KAKENHI-PROJECT-17H04656, KAKENHI-PROJECT-17K10231, KAKENHI-PROJECT-19K08585, KAKENHI-PROJECT-20K07376, KAKENHI-PROJECT-20K21632, KAKENHI-PROJECT-19H03740, KAKENHI-PROJECT-20H03719, KAKENHI-PROJECT-20H03890
[Journal Article] Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.2019
- Author(s)
  Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M, Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H.
- Journal Title
  
  Ann Thorac Surg.
  
  Volume: 19 Pages: 31717-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10631
[Journal Article] Molecular-based analysis and therapeutic development of aortic valve stenosis.2018
- Author(s)
  Sakaue T, Nakaoka H, Aono J、Kurata M, Oshima Y, Koga S, Namiguchi K Izutani H.
- Journal Title
  
  Ehime Medical Journal.
  
  Volume: 37 (1) Pages: 05-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10631
[Journal Article] The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB2018
- Author(s)
  Kovacevic Igor、Sakaue Tomohisa、Majolee Jisca、Pronk Manon C.、Maekawa Masashi、Geerts Dirk、Fernandez-Borja Mar、Higashiyama Shigeki、Hordijk Peter L.
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Issue: 3 Pages: 1015-1032
- DOI
  10.1083/jcb.201606055
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-18K07234
[Journal Article] Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen2018
- Author(s)
  Sakaue Tomohisa、Nakaoka Hirotomo、Shikata Fumiaki、Aono Jun、Kurata Mie、Uetani Teruyoshi、Hamaguchi Mika、Kojima Ai、Uchita Shunji、Yasugi Takumi、Higashi Haruhiko、Suzuki Jun、Ikeda Shuntaro、Higaki Jitsuo、Higashiyama Shigeki、Izutani Hironori
- Journal Title
  
  Biology Open
  
  Volume: 7 Issue: 8
- DOI
  10.1242/bio.034009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10631, KAKENHI-PROJECT-16H04698
[Journal Article] Cullin 3 regulates ADAMs-mediated ectodomain shedding of amphiregulin2018
- Author(s)
  Nakayama Hironao、Sakaue Tomohisa、Maekawa Masashi、Fujisaki Ayako、Higashiyama Shigeki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 499 Issue: 1 Pages: 17-23
- DOI
  10.1016/j.bbrc.2018.03.097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15221, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-16K20013, KAKENHI-PROJECT-18K07234, KAKENHI-PROJECT-16H04698
[Journal Article] Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation.2017
- Author(s)
  Sakaue T, Suzuki J, Hamaguchi M, Suehiro C, Tanino A, Nagao T, Uetani T, Aono J, Nakaoka H, Kurata M, Sakaue T, Okura T, Yasugi T, Izutani H, Higaki J, Ikeda S.
- Journal Title
  
  Hypertension
  
  Volume: 70(4) Issue: 4 Pages: 780-789
- DOI
  10.1161/hypertensionaha.117.09512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10631
[Journal Article] Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis2017
- Author(s)
  Sakaue Tomohisa、Maekawa Masashi、Nakayama Hironao、Higashiyama Shigeki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 162 Pages: 237-245
- DOI
  10.1093/jb/mvx051
- NAID
  40021380486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-16K20013
[Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017
- Author(s)
  Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
- Journal Title
  
  Biolology Open
  
  Volume: 6 Pages: 1707-1719
- DOI
  10.1242/bio.029579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09357, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038
[Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017
- Author(s)
  Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 2 Pages: 208-215
- DOI
  10.1111/cas.13133
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-17K09357
[Journal Article] Proteomics-based analysis of lung injury-induced proteins in a mouse model of common bile duct ligation.2017
- Author(s)
  Sakaue T, Shikata F, Utsunomiya K, Fukae S, Kurata M, Nakaoka H, Okazaki M, Kawanishi Y, Kojima A, Higashiyama S, Izutani H.
- Journal Title
  
  Surgery
  
  Volume: 印刷中 Issue: 6 Pages: 1525-1535
- DOI
  10.1016/j.surg.2016.12.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08668, KAKENHI-PROJECT-16K10631
[Journal Article] The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells2017
- Author(s)
  Sakaue T, Sakakibara I, Fujisaki A, Uesugi T, Nakashiro K, Hamakawa H, Kubota E, Joh T, Imai Y, Izutani H, Higashiyama S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 42845-42845
- DOI
  10.1038/srep42845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K15552, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-17K09357
[Patent] 新規ユビキチンリガーゼ及びその利用方法2017
- Inventor(s)
  東山繁樹、坂上倫久
- Industrial Property Rights Holder
  東山繁樹、坂上倫久
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K18421
[Patent] 細胞内輸送を介した膜蛋白質の分解又はリサイクリングの制御剤2017
- Inventor(s)
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Holder
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-244776
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19038
[Patent] 血管新生制御剤及びその利用法2017
- Inventor(s)
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Holder
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-193118
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19038
[Presentation] 大動脈弁石灰化における valve interstitial cells の役割2023
- Author(s)
  坂上倫久、菅野果歩、浪口謙治、黒部裕嗣、福西琢真、薦田宗則、西村　隆、泉谷裕則
- Organizer
  第53回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] 心血管代謝の最先端研究2023
- Author(s)
  坂上倫久
- Organizer
  第43回日本静脈学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] 心血管代謝を制御するタンパク質翻訳後修飾シグナル2023
- Author(s)
  坂上倫久
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] 大動脈弁石灰化におけるvalve interstitial cellsの役割2023
- Author(s)
  坂上倫久、菅野果歩、浪口謙治、黒部裕嗣、福西琢磨、薦田宗則、西村隆、泉谷裕則
- Organizer
  第53回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] 大動脈弁石灰化に寄与する弁間質細胞の特性解析2022
- Author(s)
  坂上倫久、菅野果歩, 濱口美香, 浪口謙治, 青野潤, 倉田美恵, 増本純也, 東山繁樹, 泉谷裕則
- Organizer
  第51回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] Impella挿入後の大動脈弁尖の病理学的検討2022
- Author(s)
  倉田美恵、三好徹、東晴彦、坂上倫久、井上勝次、西村隆、池田俊太郎、泉谷裕則、山口修、増本純也
- Organizer
  第27回日本血管病理研究会
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] タンパク質翻訳後修飾を介した肺癌細胞PD-L1の新たな発現制御機構2022
- Author(s)
  坂尾伸彦、坂上倫久、藻利優、桐山洋介、大谷真二、岡崎幹生、豊岡伸一、佐野由文
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09179
[Presentation] Valve interstitial cells-specific inhibins are novel regulator of osteoblast differentia tion in aortic valve2022
- Author(s)
  Tomohisa Sakaue, Kenji Namiguchi, Jun Aono, Hironori Izutani
- Organizer
  STS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] 大動脈弁石灰化に寄与する弁間質細胞の特性解析2022
- Author(s)
  坂上倫久, 菅野果歩, 濱口美香, 浪口謙治, 青野潤, 倉田美恵, 増本純也, 東山繁樹, 泉谷裕則
- Organizer
  第51回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] 心臓手術後に起こる癒着形成のメカニズム2022
- Author(s)
  坂上倫久、浪口謙治、岡﨑幹生、菅野果歩、薦田悠平、倉田美恵、太田教隆、黒部裕嗣、西村　隆、薦田宗則、檜垣知秀、八杉　巧、増本純也、泉谷裕則"
- Organizer
  日本医工学治療学会第38回学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] Angiogenesis is required for fibrosis in the pericardial cavity2022
- Author(s)
  Sakaue T,Kenji Namiguchi, Mikio Okazaki, Kaho Kanno, Yuhei Komoda, Fumiaki Shikata, Mie Kurata, Noritaka Ota, Yoshiaki Kubota, Hirotsugu Kurobe, Takashi Nishimura, Junya Masumoto, Shigeki Higashiyama, Hironori Izutani
- Organizer
  22nd International Vascular Biology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] Impellaを要した重症心不全症例において病理学的に大動脈弁尖の評価を行った3症例の検討2022
- Author(s)
  三好　徹、東　晴彦、坂上倫久、倉田美恵、井上勝次、西村　隆、池田俊太郎、泉谷裕則、山口　修"
- Organizer
  第60回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-23K24418
[Presentation] 内皮間葉転換を制御する新たなCUL3型E3ユビキチンリガーゼ2021
- Author(s)
  坂上　倫久、泉谷　裕則、東山　繁樹
- Organizer
  第26回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 石灰化大動脈弁におけるシクロオキシゲナーゼ陽性細胞の局在解析2021
- Author(s)
  坂上倫久、濱口美香、浪口謙治、倉田美恵、青野潤、山口修、泉谷裕則
- Organizer
  第74回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] トランスレーショナルリサーチによる循環器疾患発症メカニズムの解明2021
- Author(s)
  坂上倫久
- Organizer
  第94回日本生化学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] Cullin-3-based E3 ubiquitin ligases as novel regulators of angiogenesis2020
- Author(s)
  坂上倫久
- Organizer
  第42回日本血栓止血学会学術集会SPCシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] CUL3-based E3 ubiquitin ligase is essential for maintaining endothelial cell functions2020
- Author(s)
  Tomohisa Sakaue, Hironori Izutani, Shigeki Higashiyama
- Organizer
  心血管代謝週間2020/CVMW2020
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 大動脈弁狭窄症におけるリソソーム酵素の解析2020
- Author(s)
  坂上倫久、濱口美香、青野潤、中城公一、倉田美恵、浪口謙治、鹿田文昭、増本純也、山口修、泉谷裕則
- Organizer
  第73回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] マウスモデルを用いた肺虚血再灌流障害の分子機序の解明2020
- Author(s)
  薦田悠平、西田俊太、坂上倫久、岡﨑幹生、重松久之、杉本龍士郎、佐野由文、泉谷裕則
- Organizer
  第37回日本呼吸器外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09289
[Presentation] Cathepsin-positive macrophages promote stuctural deterioration with calcification2020
- Author(s)
  Tomohisa Sakaue
- Organizer
  European Association for Cardio-Thoracic Surgery 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] Identification of the Master Regulators of Aortic Valve Calcification2020
- Author(s)
  Tomohisa Sakaue
- Organizer
  The 21st international Vascular Biology Meeting
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] 新規血管内皮細胞活性化分子スイッチを標的とした血管新生制御剤の開発2019
- Author(s)
  坂上倫久、竹田浩之、藤崎亜耶子、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第60回日本生化学　中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] CUL3型 E3 ユビキチンリガーゼを標的とした血管新生制御剤の開発2019
- Author(s)
  坂上倫久、藤崎亜耶子、竹田浩之、前川大志、髙橋宏隆、澤崎龍也、泉谷裕則、東山繁樹
- Organizer
  第4回AMEDがん若手研究者ワークショップ
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 肺癌におけるPD-L1の発現制御メカニズムの解析2019
- Author(s)
  坂上倫久、中岡裕智、岡崎幹生、重松久之、杉本龍士郎、泉谷裕則、佐野由文
- Organizer
  第60回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] Neddylation活性による血管内皮細胞特性維持機構2019
- Author(s)
  坂上倫久、藤崎亜耶子、泉谷裕則、東山繁樹
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] Expression Analysis of Programmed Death-Ligand(PD-L)1 in Large Cell Neuroendocrine Carcinoma2019
- Author(s)
  Tomohisa Sakaue, Hirotomo Nakaoka, Mikio Okazaki, Hisayuki Shigematsu, Hironori Izutani, Yoshifumi Sano
- Organizer
  IASLC 2019 World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] Valve interstitial cell-specific cyclooxygenase1 is associated with calcification of aortic valves2019
- Author(s)
  Tomohisa SAKAUE, Mika HAMAGUCHI, Fumiaki SHIKATA, Jun AONO, Koh-ichi NAKASHIRO, Hironori IZUTANI"
- Organizer
  STS2019 第55回米国胸部外科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] Valve interstitial cell-specific cyclooxygenase-1 associated with calcification of aortic valves2019
- Author(s)
  Tomohisa Sakaue、Mika Hamaguchi、Jun Aono、Koh-ichi Nakashiro、Fumiaki Shikata、Hironori Izutani
- Organizer
  STS 55th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 二次元電気泳動法を用いた石灰化大動脈弁のタンパク質解析2019
- Author(s)
  坂上倫久、濱口美香、青野潤、中岡裕智、倉田美恵、鹿田文昭、浪口謙治、打田俊司、八杉巧、増本純也、東山繁樹、泉谷裕則
- Organizer
  第49回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 大動脈弁狭窄症患者由来の石灰化大動脈弁のタンパク質プロファイリング解析2019
- Author(s)
  坂上倫久、濱口美香、青野潤、鹿田文昭、浪口謙治、打田俊司、八杉巧、東山繁樹、泉谷裕則
- Organizer
  第72回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] NEDD8修飾系によるVEGFシグナル制御機構2019
- Author(s)
  坂上倫久、藤崎亜耶子、泉谷裕則、東山繁樹
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] Identification of target molecules for anti-deterioration therapy against implanted tissue valve in aortic position utilizing proteomic technology2019
- Author(s)
  Tomohisa Sakaue, Tadaaki Koyama, Yoshitugu Nakamura, Fumiaki Shikata, Izutani Hironori
- Organizer
  第33回欧州心臓胸部外科学会　EACTS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 大動脈弁異所性石灰化の分子メカニズムの解明2019
- Author(s)
  坂上倫久、濱口美香、青野潤、中城公一、倉田美恵、大嶋佑介、東山繁樹、泉谷裕則
- Organizer
  第4回黒潮カンファレンス
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 大動脈弁異所性石灰化の分子メカニズムの解明2019
- Author(s)
  坂上倫久、濱口美香、青野潤、中城公一、倉田美恵、大嶋佑介、東山繁樹、泉谷裕則
- Organizer
  第4回黒潮カンファレンス
- Data Source
  KAKENHI-PROJECT-19H03740
[Presentation] 血管内皮細胞特性維持としてのCUL3型E3ユビキチンリガーゼの役割2019
- Author(s)
  坂上倫久、藤崎亜耶子、泉谷裕則、東山繁樹
- Organizer
  第27回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] Nedd8-CUL3軸は血管内皮細胞の特異性維持に必須である2019
- Author(s)
  坂上倫久、藤崎亜耶子、泉谷裕則、東山繁樹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] Comprehensive gene expression analysis of valve interstitial cells from surgically excised stenotic aortic valves2018
- Author(s)
  Tomohisa Sakaue、Mika Hamaguchi、Jun Aono、Koh-ichi Nakashiro、Fumiaki Shikata、Kenji Namiguchi、Hirotomo Nakaoka、Mie Kurata、Shunji Uchita、Takumi Yasug、Ai Kojima、Hironori Izutani
- Organizer
  Vascular Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 高悪性度神経内分泌肺腫瘍におけるPD-L1の発現解析2018
- Author(s)
  坂上倫久、中岡裕智、藻利優、岡崎幹生、重松久之、泉谷裕則、佐野由文
- Organizer
  第３５回日本呼吸器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] 血管内皮細胞運動を制御する新規CUL3複合体の解析2018
- Author(s)
  坂上倫久、藤崎亜耶子、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第59回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 摘出大動脈弁からの弁間質細胞の調製と網羅的遺伝子発現解析2018
- Author(s)
  坂上倫久、濱口美香、青野潤、中城公一、鹿田文昭、浪口謙治、中岡裕智、倉田美恵、打田俊司、八杉巧、東山繁樹、泉谷裕則
- Organizer
  第71回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] Screening of anti-angiogenic compounds targeting for CUL3-SPOP-DAXX axis.2018
- Author(s)
  Ayako Fujisaki, Tomohisa Sakaue, Hiroyuki Takeda, Masashi Maekawa, Hirotaka Takahashi, Tatsuya Sawasaki, Hironori Izutani and Shigeki Higashiyama
- Organizer
  Protein Island Matsuyama 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 大動脈弁狭窄症患者由来石灰化大動脈弁のプロテオミクス解析2018
- Author(s)
  坂上倫久、濱口美香、青野潤、鹿田文昭、浪口謙治、中岡裕智、倉田美恵、東山繁樹、泉谷裕則
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] ユビキチンリガーゼを標的とした新規血管新生阻害化合物の探索2018
- Author(s)
  坂上倫久、藤崎亜耶子、竹田浩之、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第９回スクリーニング学研究会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] CUL3型ユビキチンリガーゼ複合体による血管新生制御機構2018
- Author(s)
  坂上倫久、前川大志、藤崎亜耶子、高橋宏隆、竹田浩之、中山寛尚、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] CUL3-based E3 ubiquitin ligase complex is essential for vascular endothelial cell motility2018
- Author(s)
  Tomohisa Sakaue、Ayako Fujisaki、Masashi Maekawa、Hirotaka Takahashi、Tatsuya Sawasaki、Hironori Izutani、Shigeki Higashiyama
- Organizer
  20th International Vascular Biology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] Cullin-3-based E3 ubiquitin ligases as novel modulators of VEGF signal transduction2018
- Author(s)
  Tomohisa Sakaue, Ayako Fujisaki, Masashi Maekawa, Hironori Izutani Shigeki Higashiyama
- Organizer
  The 16th Korea-Japan Joint Symposium on Vascular Biology（K-J meeting）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 肺癌におけるHeparin-binding Epidermal Growth factor（HB-EGF）の解析2018
- Author(s)
  坂上倫久、中岡裕智、藻利優、坂尾伸彦、岡崎幹生、重松久之、東山繁樹、佐野由文、泉谷裕則
- Organizer
  第59回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] CUL3複合体を標的とした新規血管新生阻害化合物の探索2018
- Author(s)
  坂上倫久、藤崎亜耶子、竹田浩之、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07234
[Presentation] 再弁置換術によって得られた摘出生体弁の組織学的解析2017
- Author(s)
  中岡裕智、坂上倫久、村上貴志、阪下裕司、小嶋愛、鹿田文昭、打田俊司、八杉巧、泉谷裕則
- Organizer
  第47回日本心臓血管外科学会学術総会
- Place of Presentation
  東京都港区台場グランドニッコー台場
- Year and Date
  2017-02-26
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] The roles of CUL3-based E3 ligase in vascular endothelial cells2017
- Author(s)
  坂上　倫久
- Organizer
  第２回秋期特別日本血管生物医学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] The essential roles of Cullin 3-based E3 ubiquitin ligase complex in vascular endothelial cell function and angiogenesis2017
- Author(s)
  Tomohisa Sakaue, Shigeki Higashiyama
- Organizer
  Academic Exchanges Forum Between DMU & AIDAI
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 大動脈弁置換術患者由来の摘出大動脈弁を用いた組織学的解析2017
- Author(s)
  坂上倫久、中岡裕智、鹿田文昭、村上貴志、阪下裕司、小嶋愛、打田俊司、八杉巧、泉谷裕則
- Organizer
  第47回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 摘出大動脈弁から弁細胞の調整とその特性解析2017
- Author(s)
  坂上倫久、中岡　裕智、倉田　美恵、青野　潤、鹿田文昭、村上貴志、浪口　謙治、小嶋愛、打田俊司、八杉巧、泉谷裕則
- Organizer
  第46回日本心脈管作動物質学会年会
- Place of Presentation
  琉球大学医学部
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 大動脈弁置換術における摘出大動脈弁を用いたα-SMAの発現解析2017
- Author(s)
  中岡裕智、坂上倫久、鹿田文昭、村上貴志、阪下裕司、小嶋愛、打田俊司、八杉巧、泉谷裕則
- Organizer
  第１１７回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] ヒト血管内皮機能障害関連疾患におけるアンジオテンシン変換酵素2 (ACE2)およびMas受容体の発現解析2017
- Author(s)
  中岡　裕智、坂上倫久、倉田　美恵、青野　潤、鹿田文昭、村上貴志、浪口　謙治、小嶋愛、打田俊司、八杉巧、泉谷裕則
- Organizer
  第46回日本心脈管作動物質学会年会
- Place of Presentation
  琉球大学医学部
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 摘出大動脈弁由来間質細胞の調整とその特性解析2017
- Author(s)
  坂上倫久、中岡裕智、倉田美恵、青野潤、鹿田文昭、村上貴志、浪口謙治、小嶋愛、打田俊司、八杉巧、泉谷裕則
- Organizer
  第46回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017
- Author(s)
  Tomohisa Sakaue, Ayako Fujisaki, Masashi Maekawa, Hironori Izutani, Shigeki Higashiyama
- Organizer
  Protein Island Matsuyama 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 弁置換術によって得られた摘出大動脈弁のプロテオミクス解析2017
- Author(s)
  坂上倫久、中岡裕智、鹿田文昭、村上貴志、阪下裕司、小嶋愛、打田俊司、八杉巧、泉谷裕則
- Organizer
  第１１７回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 血管新生制御を担うCul3-based E3 ubiquitin ligaseの機能解析2017
- Author(s)
  坂上倫久、藤崎亜耶子、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第22回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] ヒト血管内皮機能障害関連疾患におけるアンジオテンシン変換酵素2 (ACE2)およびMas受容体の発現解析2017
- Author(s)
  中岡裕智、坂上倫久、倉田美恵、青野潤、村上貴志、浪口謙治、小嶋愛、鹿田文昭、打田俊司、八杉巧、泉谷裕則
- Organizer
  第46回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 再弁置換術によって得られた摘出生体弁の組織学的解析2017
- Author(s)
  中岡裕智、坂上倫久、村上貴志、阪下裕司、小嶋愛、鹿田文昭、打田俊司、八杉巧、泉谷裕則
- Organizer
  第47回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] NEDD8化シグナル伝達経路は血管内皮細胞運動を制御する2017
- Author(s)
  坂上倫久、前川大志、藤崎亜耶子、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 新規CUL3複合体による血管新生制御機構2017
- Author(s)
  坂上倫久、前川大志、藤崎亜耶子、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
- Organizer
  第25回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] Plasminogen and fibrinogen promote calcification in bioprosthetic valve leaflets in aortic position2017
- Author(s)
  Tomohisa Sakaue, Hirotomo Nakaoka, Fumiaki Shikata, Jun Aono, Mie Kurata, Teruyoshi Uetani, Takashi Murakami1, Yuji Sakashita, Ai Kojima, Shunji Uchita, Takumi Yasugi, Shigeki Higashiyama, Hironori Izutani.
- Organizer
  31st EACTS 2017 Annual Meeting - European Association for Cardio-Thoracic Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] "肺癌細胞におけるProgrammed Death-Ligand 1（PD-L1）の細胞内タンパク質代謝機序2017
- Author(s)
  坂上倫久、藻莉優、坂尾伸彦、岡崎幹生、重松久之、東山繁樹、佐野由文、泉谷裕則
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 大動脈弁置換術患者由来の摘出大動脈弁を用いた組織学的解析2017
- Author(s)
  坂上倫久、中岡裕智、鹿田　文昭、村上貴志、阪下裕司、小嶋愛、打田俊司、八杉　巧、東山　繁樹、泉谷裕則
- Organizer
  第47回日本心臓血管外科学会学術総会
- Place of Presentation
  東京都港区台場グランドニッコー台場
- Year and Date
  2017-02-26
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] 肺がん組織におけるProgrammed Death-Ligand 1（PD-L1）の発現とその制御メカニズムの解析2017
- Author(s)
  中岡裕智、坂上倫久、藻利優、坂尾伸彦、岡崎幹生、重松久之、倉田美恵、東山繁樹、佐野由文、泉谷裕則
- Organizer
  第34回日本呼吸器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] 外科的切除した肺癌組織を用いたHeparin Binding EGF Like Growth Factor (HB-EGF)の解析2017
- Author(s)
  坂上倫久、中岡裕智、藻利優、坂尾伸彦、岡崎幹生、重松久之、佐野由文、泉谷裕則
- Organizer
  第34回日本呼吸器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] 肺癌細胞におけるProgrammed Death-Ligand1(PD-L1)の細胞内タンパク質代謝機序の解明2017
- Author(s)
  坂上倫久、藻莉優、坂尾伸彦、岡崎幹生、重松久之、東山繁樹、佐野由文、泉谷裕則
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10791
[Presentation] CUL3による血管内皮細胞活性化制御機構2016
- Author(s)
  坂上倫久、藤崎亜耶子、泉谷裕則、東山繁樹
- Organizer
  日本病態プロテアーゼ学会　第21回学術集会
- Place of Presentation
  豊中千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2016-08-16
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 血管内皮細胞においてCUL3はVEGFR2の発現を制御する2016
- Author(s)
  坂上倫久
- Organizer
  がん支援　冬期公開シンポジウム
- Place of Presentation
  東京都千代田区
- Year and Date
  2016-02-09
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] CUL3によるVE-cadherinモジュレーションを介した血管内皮細胞接着制御機構の解析2016
- Author(s)
  藤崎亜耶子, 坂上倫久, 中山寛尚, 前川大志, 東山繁樹
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 血管内皮細胞におけるCUL3によるVEGF-A応答制御機構2016
- Author(s)
  坂上　倫久、藤崎　亜耶子、泉谷　裕則、東山　繁樹
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] CUL3によるVE-cadherinを介した血管内皮細胞接着制御2016
- Author(s)
  藤崎亜耶子、坂上倫久、中山寛尚、前川大志、東山繁樹
- Organizer
  第57回日本生化学会中国・四国支部例会（高知）
- Place of Presentation
  高知大学医学部（高知県南国市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] EGFファミリー分子のshedding特性解析2016
- Author(s)
  中山寛尚、坂上倫久、前川大志、藤崎亜耶子、東山繁樹
- Organizer
  第57回日本生化学会中国・四国支部例会（高知）
- Place of Presentation
  高知大学医学部（高知県南国市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.2016
- Author(s)
  Tomohisa Sakaue、Ayako Fujisaki、Hironori Izutani、Shigeki Higashiyama.
- Organizer
  Protein Island Matsuyama 2016 & The 14th Matsuyama International Symposium.
- Place of Presentation
  愛媛大学城北キャンパス（愛媛県松山市）
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in endothelial cells2016
- Author(s)
  Sakaue Tomohisa, Fujisaki Ayako, Izutani Hironori, Higashiyama Shigeki
- Organizer
  The 19th International Vascular Biology Meeting
- Place of Presentation
  Sheraton Boston Hotel (USA)
- Year and Date
  2016-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] CUL3-KLHL20軸による細胞内タンパク質輸送制御機構の解析2016
- Author(s)
  宇都宮果歩, 深江舜也, 上杉恭広, 坂上倫久, 中山寛尚, 前川大志, 泉谷裕則,東山繁樹
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K18421
[Presentation] 大動脈弁狭窄症患者由来の摘出大動脈弁を用いたヘパリン結合性EGF様成長因子（HB-EGF）の解析2016
- Author(s)
  坂上倫久、中岡裕智、鹿田　文昭、村上貴志、阪下裕司、小嶋愛、打田俊司、八杉　巧、東山　繁樹、泉谷裕則
- Organizer
  第69回日本胸部外科学会定期学術集会
- Place of Presentation
  岡山市
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-16K10631
[Presentation] CUL3 regulates vascular endothelial cell-specific gene expression2015
- Author(s)
  坂上倫久, 藤崎亜耶子, 中城公一, 浜川裕之, 泉谷裕則, 東山繁樹
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会,
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] Cullin3-KCTD10 regulates angiogenesis through controlling levels of RhoA2015
- Author(s)
  Tomohisa Sakaue, Ayako Fujisaki, Shigeki Higashiyama
- Organizer
  Protein Island Matsuyama International Symposium 2015
- Place of Presentation
  愛媛県松山市
- Year and Date
  2015-08-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] AlphaScreenを用いたCUL3複合体解析システムの構築2015
- Author(s)
  藤崎亜耶子, 宇都宮果歩, 上杉恭広, 深江舜也, 坂上倫久, 高橋宏隆, 澤崎達也, 東山繁樹
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] CUL3/SPOP/Daxx複合体によるVEGFR2の発現制御機構2015
- Author(s)
  坂上　倫久、藤崎　亜耶子、東山　繁樹
- Organizer
  第56回日本生化学会中国・四国支部例会
- Place of Presentation
  島根県松江市
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] Analysis of novel Nrf2-binding BTB proteins　using AlphaScreen assay2015
- Author(s)
  宇都宮果歩, 上杉恭広, 深江舜也, 藤崎亜耶子, 坂上倫久, 高橋宏隆, 澤崎達也, 東山繁樹
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] KLHL20, CUL3-binding protein, regulates expression of EGFR family proteins2015
- Author(s)
  深江舜也, 上杉恭広, 宇都宮果歩, 坂上倫久, 泉谷　裕則, 東山繁樹.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] 血管内皮細胞におけるCUL3の機能解析2015
- Author(s)
  坂上倫久, 藤崎亜耶子, 中城公一, 浜川裕之, 泉谷裕則, 東山繁樹
- Organizer
  第23回日本血管生物医学会学術集会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] CUL3 regulates expression of EGF receptor family proteins2015
- Author(s)
  上杉恭広, 宇都宮果歩, 深江舜也, 坂上倫久, 中山　寛尚, 福田　信治, 泉谷　裕則, 東山繁樹
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] Versatility of E3 ubiquitin ligase Cullin3 as an angiogenic balance regulator2014
- Author(s)
  Tomohisa Sakaue
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25893160
[Presentation] Cullin3　E3 ubiquitin ligase regulates angiogenesis through stabilizing vascular endothelial growth factor receptor 2 mRNA.2013
- Author(s)
  Tomohisa Sakaue
- Organizer
  North American Vascular Biology Organization
- Place of Presentation
  Hyannis, MA, USA
- Data Source
  KAKENHI-PROJECT-25893160
[Presentation] BTB proteins as an adaptor for Cul3-based ubiquitin ligases multiply regulate angiogenesis
- Author(s)
  Tomohisa Sakaue, Shigeki Higashiyama
- Organizer
  Joint International Symposium on TGF-β Family and Cancer Signal Network in Tumor Microenvironment
- Place of Presentation
  茨城県つくば市
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] Versatility of E3 ubiquitin ligase Cullin3 as an angiogenic balance regulator
- Author(s)
  Tomohisa Sakaue, Shigeki Higashiyama
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] CUL3は多様な血管新生制御遺伝子の発現
- Author(s)
  坂上　倫久, 東山繁樹
- Organizer
  第５５回日本生化学会中国四国支部例会
- Place of Presentation
  愛媛県松山市
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] CUL3はRhoタンパク質の発現および活性制御を介して血管新生を調節する
- Author(s)
  坂上　倫久, 東山繁樹
- Organizer
  第８７回日本生化学大会
- Place of Presentation
  京都府京都市
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26830077
[Presentation] E3ユビキチンリガーゼCUL3による血管新生制御機構の解析
- Author(s)
  坂上　倫久, 東山繁樹
- Organizer
  第19回日本病態プロテアーゼ学会学術集
- Place of Presentation
  大阪府豊中市
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-26830077

1. Okazaki Mikio (50467750)

# of Collaborated Projects: 9 results

# of Collaborated Products: 9 results
2. Hironori Izutani (90419200)

# of Collaborated Projects: 7 results

# of Collaborated Products: 41 results
3. Yoshifumi Sano (60322228)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
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7. 豊岡伸一 (30397880)

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43. NANBA Daisuke

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44. IMAI Yuuki

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45. 増本純也

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46. 日吉裕美

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48. 久保田英嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 榊原伊織

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 中山寛尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakaue Tomohisa 坂上 倫久

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Understanding the molecular mechanism of aortic valve calcification at the single-cell levelPrincipal Investigator

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Sakaue Tomohisa 坂上倫久