MIKAMI NORIHISA 三上統久

… Alternative Names

三上統久ミカミノリヒサ

MIKAMI Norihisa 三上統久

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Researcher Number	20710388
Other IDs
Affiliation (Current)	2025: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2024 – 2025: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2020: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2018: 大阪大学, 免疫学フロンティア研究センター・実験免疫学, 招へい教員 2017: 京都大学, ウイルス・再生医科学研究所, 特定助教 2015 – 2016: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2013 – 2014: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Biological pharmacy / Immunology Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Immunology / Biological Sciences
Keywords	Principal Investigator 制御性T細胞 / 免疫記憶 / Treg / 低酸素応答 / 低酸素 / 免疫学 / cAMP Except Principal Investigator 制御性T細胞 / T細胞分化 / ゲノム解析 … More / 自己免疫病 / 免疫制御 / フィンゴリモド / Interleukin-10 / 寛解 / 関節リウマチ / 病因抗原 / 免疫寛容 / FTY720 / interleukin-10 / 免疫自己寛容 / 発生・分化 / 発現制御 / シグナル伝達 / 免疫学 / エピジェネティクス / Foxp3 / 自己免疫疾患 / 自己免疫寛容 Less

ステロイド抵抗性自己免疫疾患に対する抗原特異的iTreg細胞治療法の開発Principal Investigator
- Principal Investigator
  
  三上統久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Osaka
Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Osaka University
Basic research on new therapeutic strategy for rheumatoid arthritis to induction of immune tolerance
- Principal Investigator
  
  Yoshida Yuya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Setsunan University
Study of the function and development of regulatory T cells
- Principal Investigator
  
  Shimon Sakaguchi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
The effect of hypoxia on regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Mikami Norihisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto University
  Osaka University
The roles of cyclic adenosine monophosphate (cAMP) in suppressive functions of regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  MIKAMI Norihisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Osaka University

All 2021 2020 2019 2018 2017 2016 2013

All Journal Article Presentation Book Patent

[Book] 臨床免疫・アレルギー科　Vol75 No.32021
- Author(s)
  三上統久・坂口志文
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16H06295
[Book] 実験医学　Vol.38 No.17（増刊）2020
- Author(s)
  三上統久・坂口志文
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16H06295
[Book] 週刊医学のあゆみ　Vol.275 No.12020
- Author(s)
  三上統久・坂口志文
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression2020
- Author(s)
  Mikami Norihisa、Kawakami Ryoji、Sakaguchi Shimon
- Journal Title
  
  Current Opinion in Immunology
  
  Volume: 67 Pages: 36-41
- DOI
  10.1016/j.coi.2020.07.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation2020
- Author(s)
  Mikami Norihisa、Kawakami Ryoji、Chen Kelvin Y.、Sugimoto Atsushi、Ohkura Naganari、Sakaguchi Shimon
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 22 Pages: 12258-12268
- DOI
  10.1073/pnas.1922600117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Regulatory T Cells and Human Disease2020
- Author(s)
  Sakaguchi Shimon、Mikami Norihisa、Wing James B.、Tanaka Atsushi、Ichiyama Kenji、Ohkura Naganari
- Journal Title
  
  Annual Review of Immunology
  
  Volume: 38 Issue: 1 Pages: 541-566
- DOI
  10.1146/annurev-immunol-042718-041717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-18K07177, KAKENHI-PROJECT-16H06295
[Journal Article] Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/192019
- Author(s)
  Akamatsu Masahiko、Mikami Norihisa、Ohkura Naganari、Kawakami Ryoji、Kitagawa Yohko、Sugimoto Atsushi、Hirota Keiji、Nakamura Naoto、Ujihara Satoru、Kurosaki Toshio、Hamaguchi Hisao、Harada Hironori、Xia Guliang、Morita Yoshiaki、Aramori Ichiro、Narumiya Shuh、Sakaguchi Shimon
- Journal Title
  
  Science Immunology
  
  Volume: 4 Issue: 40
- DOI
  10.1126/sciimmunol.aaw2707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553
[Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.2017
- Author(s)
  Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 7 Pages: 1824-1838
- DOI
  10.1016/j.celrep.2017.10.082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08838, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-17H04190, KAKENHI-PROJECT-15K08274
[Journal Article] Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.2017
- Author(s)
  Hosokawa T, Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, Kumanogoh A.
- Journal Title
  
  J Immunol.
  
  Volume: 199 Issue: 6 Pages: 2008-2019
- DOI
  10.4049/jimmunol.1700157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19596, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H06004, KAKENHI-PROJECT-15H04296, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-15K08423
[Journal Article] Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system.2016
- Author(s)
  Vandenbon A, Dinh VH, Mikami N, Kitagawa Y, Teraguchi S, Ohkura N, Sakaguchi S.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113(17) Issue: 17
- DOI
  10.1073/pnas.1604351113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H06295
[Patent] 制御性T細胞の作製法2018
- Inventor(s)
  坂口　志文、三上　統久
- Industrial Property Rights Holder
  坂口　志文、三上　統久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-155507
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Glucose-6-phophate isomerase peptide (GPI325-339) 誘導性関節炎に対するFTY720と病因抗原併用療法の有用性とそのメカニズム - 第七報-: IL-10高産生性T細胞のRNA-seq 解析2019
- Author(s)
  長池新、才本麻矢、下野遥香、吉田侑矢、三上統久、坂野理絵、辻琢己、河野武幸
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] Induction of immune tolerance by combination treatment with fingolimod (FTY720) plus pathogenic antigen in s glicose-6-phosphate isomerase peptide-induced arthritis mouse model: the fifth report2018
- Author(s)
  Yuya Yoshida, Norihisa Mikami, Rie Banno, Takumi Tsuji, Takeyuki Kohno
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] 関節リウマチに効果的に免疫寛容を導入できる治療戦略の探索2018
- Author(s)
  吉田侑矢、三上統久、河野武幸
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] Induction of immune tolerance by combination treatment with fingolimod (FTY720) plus pathogenic antigen in a glucose-6-phosphate isomerase peptide-induced arthritis mouse model: the fourth report.2017
- Author(s)
  Yuya Yoshida、Norihisa Mikami、Rie Banno、Takumi Tsuji、Takeyuki Kohno
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] Epigenomic signatures of extrathymic-derived regulatory T-cells2017
- Author(s)
  Ryoji Kawakami, Norihisa Mikami, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  第46回日本免疫学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] FTY720と病因抗原の併用療法が誘導するTr1様細胞の特性解析2017
- Author(s)
  中西祐亮、才本麻矢、長池新、吉田侑矢、三上統久、坂野理絵、辻琢己、河野武幸
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] Roles of cyclic adenosine monophosphate (cAMP) in suppressive functions of regulatory T cells.2013
- Author(s)
  三上統久
- Organizer
  e the 2013 Annual Meeting of the Japan Society for Immunology (JSI).
- Place of Presentation
  幕張メッセ，千葉
- Data Source
  KAKENHI-PROJECT-25893115

1. Shimon Sakaguchi (30280770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 市山健司 (60777960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Yoshida Yuya (50581435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. KOHNO Takeyuki (50178224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. TSUJI Takumi (90454652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. BANNO Rie (90736844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. ウィングジェイムス (00648694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 竹島雄介 (70893288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Chen KelvinYigene (00898851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHKURA Naganari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. UMEMOTO Eui

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 岡田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIKAMI NORIHISA 三上 統久

三上 統久 ミカミ ノリヒサ

MIKAMI Norihisa 三上 統久

Research Projects

Research Products

Co-Researchers

ステロイド抵抗性自己免疫疾患に対する抗原特異的iTreg細胞治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research on new therapeutic strategy for rheumatoid arthritis to induction of immune tolerance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the function and development of regulatory T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of hypoxia on regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of cyclic adenosine monophosphate (cAMP) in suppressive functions of regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 臨床免疫・アレルギー科 Vol75 No.32021

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学 Vol.38 No.17（増刊）2020

Author(s)

Total Pages

Publisher

Data Source

[Book] 週刊医学のあゆみ Vol.275 No.12020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory T Cells and Human Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/192019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.2017

Author(s)

Journal Title

MIKAMI NORIHISA 三上統久

三上統久ミカミノリヒサ

MIKAMI Norihisa 三上統久

[Book] 臨床免疫・アレルギー科　Vol75 No.32021

[Book] 実験医学　Vol.38 No.17（増刊）2020

[Book] 週刊医学のあゆみ　Vol.275 No.12020