Takeshima Yusuke 竹島雄介

Researcher Number	70893288
Other IDs	https://orcid.org/0000-0001-8312-9309
Affiliation (Current)	2025: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2024 – 2025: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2022 – 2023: 大阪大学, 免疫学フロンティア研究センター, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 49070:Immunology-related Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 免疫学 / 制御性T細胞 / シングルセル解析 / トランスオミクス解析 / マルチオミクス解析 Except Principal Investigator T細胞分化 / ゲノム解析 / 自己免疫病 / 免疫制御 / 制御性T細胞 … More / バイオインフォマティクス / 次世代シークエンス / 疾患ゲノム解析 / 免疫アレルギー疾患 / シングルセル解析 / オミクス解析 / シングルセルシークエンス / 統合シークエンス解析 / オミクス / シングルセル / 遺伝統計学 Less

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Osaka
Elucidation of the Pathological Contribution of Regulatory T Cells in Autoimmune Diseases by Trans-omics Analysis.Principal Investigator
- Principal Investigator
  
  竹島雄介
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka University
Elucidation of Signaling Mechanisms Involved in Human Regulatory T Cell Differentiation by Multi-omics AnalysisPrincipal Investigator
- Principal Investigator
  
  Takeshima Yusuke
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
Elucidation of immune and allergic disease dynamics by integrative sequencing analysis
- Principal Investigator
  
  Okada Yukinori
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Methylglyoxal compromises callus mineralization and impairs fracture healing through suppression of osteoblast terminal differentiation2025
- Author(s)
  Seto Tetsuya, Yukata Kiminori, Tsuji Shunya, et al
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 747 Pages: 151312-151312
- DOI
  10.1016/j.bbrc.2025.151312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14085, KAKENHI-PROJECT-24K19242
[Journal Article] Genome-wide CRISPR screen in human T cells reveals regulators of FOXP32025
- Author(s)
  Chen Kelvin Y.、Kibayashi Tatsuya、Giguelay Ambre、Hata Mayu、Nakajima Shunsuke、Mikami Norihisa、Takeshima Yusuke、Ichiyama Kenji、Omiya Ryusuke、Ludwig Leif S.、Hattori Kunihiro、Sakaguchi Shimon
- Journal Title
  
  Nature
  
  Volume: online Issue: 8066 Pages: 191-200
- DOI
  10.1038/s41586-025-08795-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24H00610, KAKENHI-PROJECT-23K14545, KAKENHI-PROJECT-22K21354
[Journal Article] Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases2024
- Author(s)
  Yasumizu Yoshiaki、Takeuchi Daiki、Morimoto Reo、Takeshima Yusuke、Okuno Tatsusada、Kinoshita Makoto、Morita Takayoshi、Kato Yasuhiro、Wang Min、Motooka Daisuke、Okuzaki Daisuke、Nakamura Yamami、Mikami Norihisa、Arai Masaya、Zhang Xuan、Kumanogoh Atsushi、Mochizuki Hideki、Ohkura Naganari、Sakaguchi Shimon
- Journal Title
  
  Cell Genomics
  
  Volume: 4 Issue: 2 Pages: 100473-100473
- DOI
  10.1016/j.xgen.2023.100473
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15493, KAKENHI-PROJECT-23K27671, KAKENHI-PROJECT-24K02294
[Journal Article] Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of <scp>Myositis‐Specific Antibody‐Positive</scp> Inflammatory Myopathies2023
- Author(s)
  Sugimori Yusuke、Iwasaki Yukiko、Takeshima Yusuke、Okubo Mai、Kobayashi Satomi、Hatano Hiroaki、Yamada Saeko、Nakano Masahiro、Yoshida Ryochi、Ota Mineto、Tsuchida Yumi、Nagafuchi Yasuo、Shimane Kenichi、Yoshida Ken、Kurosaka Daitaro、Sumitomo Shuji、Shoda Hirofumi、Yamamoto Kazuhiko、Okamura Tomohisa、Fujio Keishi
- Journal Title
  
  ACR Open Rheumatology
  
  Volume: 5 Issue: 2 Pages: 93-102
- DOI
  10.1002/acr2.11521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-22K15493
[Journal Article] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity2023
- Author(s)
  Japan COVID-19 Task Force
- Journal Title
  
  Nature Genetics
  
  Volume: 55 Issue: 5 Pages: 753-767
- DOI
  10.1038/s41588-023-01375-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16624, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-23K11300, KAKENHI-PROJECT-21K09068, KAKENHI-PROJECT-22K15493, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K27671
[Presentation] シングルセルマルチオミクス・空間遺伝子発現解析による尿路上皮癌腫瘍微小環境の解明2024
- Author(s)
  牧野克洋、佐藤悠佑、村田高史、竹島雄介、畑まゆ、Kelvin Y. Chen、久米春喜、坂口志文
- Organizer
  第62 回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-24H00610

1. Okada Yukinori (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 奥野龍禎 (00464248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 田中良哉 (30248562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 駒形嘉紀 (60281995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 熊坂夏彦 (80525527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 藤本学 (90272591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 王青波 (00916033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 坂口志文 (30280770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Chen KelvinYigene (00898851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 三上統久 (20710388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 市山健司 (60777960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 辻竣也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小林聖未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshima Yusuke 竹島 雄介

Research Projects

Research Products

Co-Researchers

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Pathological Contribution of Regulatory T Cells in Autoimmune Diseases by Trans-omics Analysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Signaling Mechanisms Involved in Human Regulatory T Cell Differentiation by Multi-omics AnalysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of immune and allergic disease dynamics by integrative sequencing analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Methylglyoxal compromises callus mineralization and impairs fracture healing through suppression of osteoblast terminal differentiation2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide CRISPR screen in human T cells reveals regulators of FOXP32025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of <scp>Myositis‐Specific Antibody‐Positive</scp> Inflammatory Myopathies2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] シングルセルマルチオミクス・空間遺伝子発現解析による尿路上皮癌腫瘍微小環境の解明2024

Author(s)

Organizer

Data Source

Takeshima Yusuke 竹島雄介