fujimoto manabu 藤本学

… Alternative Names

Researcher Number	90272591
Other IDs
External Links
Affiliation (Current)	2020: 大阪大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 大阪大学, 医学系研究科, 教授 2013 – 2018: 筑波大学, 医学医療系, 教授 2008 – 2012: Kanazawa University, 医学系, 准教授 2007: Kanazawa University, Graduate Shcool of Meclical Science, Associate Professor 2005 – 2006: Kanazawa University, School of Medicine, Associate Professor, 医学系研究科, 助教授 … More
Review Section/Research Field	Principal Investigator Dermatology / Biological Sciences / Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Dermatology
Keywords	Principal Investigator B細胞 / 免疫 / 皮膚免疫 / 自己免疫疾患 / 自己免疫 / 膠原病 / 皮膚疾患 / 細胞 / 皮膚 / 強皮症 … More Except Principal Investigator TGF-β / CTGF / collagen / 線維化 / c-myc / コラーゲン / fibrosis / b-FGF / 繊維化 / 中和抗体 / 線維芽細胞 / モノクロナール抗体 / 皮膚生理学 / monoclonal antibody Less

皮膚筋炎特異的自己抗原に対する免疫応答が皮膚筋炎の病態を形成する分子機序の解明Principal InvestigatorOngoing
- Principal Investigator
  
  藤本学
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Osaka University
  University of Tsukuba
B cell and autoantibody in the pathogenesis of dermatomyositisPrincipal Investigator
- Principal Investigator
  
  Fujimoto Manabu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Tsukuba
Development of therapy for skin diseases by utilizing regulatory B cellsPrincipal Investigator
- Principal Investigator
  
  Fujimoto Manabu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  University of Tsukuba
Identification of new regulatory B cell subsets suppressing fibrosisPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Manabu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  University of Tsukuba
  Kanazawa University
Molecular mechanisms of regulatory B cell inhibition on skin immunological diseasesPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Manabu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Tsukuba
  Kanazawa University
Identification of marker molecules specific for regulatory B cellsPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Manabu
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
制御性B細胞の機能解析と自己免疫疾患の抑制機構Principal Investigator
- Principal Investigator
  
  藤本学
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Molecular mechanisms of regulatory B cells in immuno-dermatological diseasesPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Manabu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Developmentoftherapies for autoimmune diseases by targeting B cellsignalingPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Manabu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The inhibition by anti-CTGF antibody produced by the DNA immunization method in the cytokine induced skin fibrosis model mice
- Principal Investigator
  
  TAKEHARA Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
免疫担当細胞におけるCD83の機能と皮膚疾患との関連Principal Investigator
- Principal Investigator
  
  藤本学
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
  The University of Tokyo
The investigation of the mechanisms of upregulated collagen production of cytokine-induced skin fibrosis model.
- Principal Investigator
  
  TAKEHARA Kazuhiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  KANAZAWA UNIVERSITY
CD19によるB細胞活性化シグナルの制御メカニズムPrincipal Investigator
- Principal Investigator
  
  藤本学
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Research Institute, International Medical Center of Japan
自己免疫疾患におけるB細胞のシグナル伝達異常Principal Investigator
- Principal Investigator
  
  藤本学
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Research Institute, International Medical Center of Japan
  The University of Tokyo

All 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] 制御性B細胞とは, What's New in皮膚科学2012-20132012
- Author(s)
  藤本学
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23659544
[Journal Article] Blockade of p38 Mitogen-Activated Protein Kinase Inhibits Murine Sclerodermatous Chronic Graft-versus-Host Disease.2017
- Author(s)
  Matsushita T, Date M, Kano M, Mizumaki K, Tennichi M, Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K.
- Journal Title
  
  Am J Pathol
  
  Volume: 187 Pages: 841-850
- DOI
  10.1016/j.ajpath.2016.12.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04885
[Journal Article] Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity.2016
- Author(s)
  Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
- Journal Title
  
  Rheumatology
  
  Volume: 55 Pages: 263-267
- DOI
  10.1093/rheumatology/kev331
- NAID
  120005764209
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461680, KAKENHI-PROJECT-25461686, KAKENHI-PROJECT-15H04885
[Journal Article] Recent advances in dermatomyositis-specific autoantibodies.2016
- Author(s)
  Fujimoto M, Watanabe R, Ishitsuka Y, Okiyama N.
- Journal Title
  
  Curr Opin Rheumatol
  
  Volume: 28 Pages: 636-644
- DOI
  10.1097/bor.0000000000000329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04885, KAKENHI-PROJECT-16H06663, KAKENHI-PROJECT-15K09757
[Journal Article] A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol-3-kinase-Akt pathway activation.2016
- Author(s)
  MatsushitaT, Huu DL, Hamaguchi Y, Hasegawa M, Naka K, Hirao A, Muramatsu M, Takehara K, Fujimoto M.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 印刷中 Pages: 1170-1182
- DOI
  10.1016/j.jaci.2015.12.1319
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01509, KAKENHI-PROJECT-15H02361, KAKENHI-PROJECT-15H04885, KAKENHI-PROJECT-26290038
[Journal Article] Enzyme-linked immunosorbent assays for detection of anti-transcriptional intermediary factor-1 gamma and anti-Mi-2 autoantibodies in dermatomyositis.2016
- Author(s)
  Fujimoto M, Murakami A, Kurei S, Okiyama N, Kawakami A, Mishima M, Sato S, Seishima M, Suda T, Mimori T, Takehara K, Kuwana M.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 84 Pages: 272-281
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04885
[Journal Article] B cells promote tumor immunity against B16F10 melanoma.2014
- Author(s)
  Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K, Matsushita T.
- Journal Title
  
  Am J Pathol
  
  Volume: 184 Pages: 3120-3129
- DOI
  10.1016/j.ajpath.2014.07.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461686, KAKENHI-PROJECT-26670521
[Journal Article] Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease.2014
- Author(s)
  Le Huu D, Kimura H, Date M, Hamaguchi Y, Hasegawa M, Hau KT, Fujimoto M, Takehara K, Matsushita T.
- Journal Title
  
  J Dermatol Sci
  
  Volume: in press
- DOI
  10.1016/j.jdermsci.2014.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659523
[Journal Article] Blockade of Syk Ameliorates the development of murine sclerodermatous chronic graft-versus-host disease2014
- Author(s)
  Le Huu D, Kimura H, Date M, Hamaguchi Y, Hasegawa M, Hau KT, Fujimoto M, Takehara K, Matsushita T.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 74 Pages: 214-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659523
[Journal Article] Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement2014
- Author(s)
  Kaji K, Fertig N, Medsger TA Jr, Satoh T, Hoshino K, Hamaguchi Y, Hasegawa M, Lucas M, Schnure A, Ogawa F, Sato S, Takehara K, Fujimoto M, Kuwana M.
- Journal Title
  
  Arthritis Care Res (Hoboken)
  
  Volume: 66 Pages: 575-584
- DOI
  10.1002/acr.22163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-26461471
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, T akehara K, T edder TF, Fujimoto M
- Journal Title
  
  Blood.
  
  Volume: 121 Pages: 3274-83
- DOI
  10.1182/blood-2012-11-465658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-24659523
[Journal Article] Circulating gamma/delta T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts2013
- Author(s)
  Ueda-Hayakawa I, Hasegawa M, Hamaguchi Y, Takehara K, Fujimoto M.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 69 Pages: 54-60
- DOI
  10.1016/j.jdermsci.2012.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659523
[Journal Article] B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells2013
- Author(s)
  Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Huu DL, Ishiura N, Naka K, Hirao A, Takehara K, Fujimoto M
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 131 Pages: 1674-1682
- DOI
  10.1016/j.jaci.2013.01.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M
- Journal Title
  
  Arthritis Rheum.
  
  Volume: in press Pages: 1624-35
- DOI
  10.1002/art.37933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24659523, KAKENHI-PROJECT-25461686
[Journal Article] Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis2013
- Author(s)
  Arai M, Ikawa Y, Chujo S, Hamaguchi Y, Ishida W, Shirasaki F, Hasegawa M, Mukaida N, Fujimoto M, Takehara K.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 69 Pages: 250-8
- DOI
  10.1016/j.jdermsci.2012.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659523
[Journal Article] 制御性B細胞と接触過敏反応日本皮膚アレルギー学会2012
- Author(s)
  藤本学
- Journal Title
  
  接触皮膚炎学会雑誌
  
  Volume: 6 Pages: 55-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659544
[Journal Article] IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease.2012
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, T akehara K, Fujimoto M
- Journal Title
  
  J Invest Dermato
  
  Volume: 132 Pages: 2752-2761
- DOI
  10.1038/jid.2012.226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-24659523
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis.2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, T akehara K
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 64 Pages: 3726-35
- DOI
  10.1002/art.34643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24220011
[Journal Article] Basophils and Mast Cells Play Critical Roles for Leukocyte R ecruitment in IgE-Mediated Cutaneous Reverse Passive Arthus Reaction2012
- Author(s)
  Jin G, Matsushita T, Hamaguchi Y, Le H uu D, Ishii T, Hasegawa M, Obata K Kar asuyama H, Takehara K, Fujimoto M
- Journal Title
  
  J.Dermato.Sci.
  
  Volume: 67 (3) Pages: 181-189
- DOI
  10.1016/j.jdermsci.2012.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J05115, KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-24390093
[Journal Article] 制御性B細胞と自己免疫疾患2011
- Author(s)
  藤本学、松下貴史
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 56 Pages: 338-345
- NAID
  40019017871
- Data Source
  KAKENHI-PROJECT-23659544
[Journal Article] Regulatory B cells (B10 cells) have a suppressive role in murine lupus : CD19 and B10 cell deficiency exacerbates systemic autoimmunity2010
- Author(s)
  Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M.
- Journal Title
  
  Journal of Immunology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Inducible costimulator ligand (ICOSL) regulates bleomycin-induced lung and skin fibrosis independent of ICOS-ICOSL pathway.2010
- Author(s)
  Tanaka C, Fujimoto M, Hamaguchi Y, Sato S, Takehara K, Hasegawa M.
- Journal Title
  
  Arthritis Rheum 62
  
  Pages: 1723-1732
- NAID
  10029469768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Regulatory B cells in skin and connective tissue diseases2010
- Author(s)
  Fujimoto M.
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 60 Pages: 1-7
- NAID
  10027473489
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021017
[Journal Article] Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.2010
- Author(s)
  Haas KM, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, Fujimoto M, Tedder TF.
- Journal Title
  
  J Immunol. 184
  
  Pages: 4789-4800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Regulatory B cells (B10 cells) have a suppressive role in murine lupus : CD19 and B10 cell deficiency exacerbates systemic autoimmunity.2010
- Author(s)
  Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M.
- Journal Title
  
  J Immunol 184
  
  Pages: 4801-4809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.2010
- Author(s)
  Nakashima H, Hamaguchi Y, Watanabe R, Ishiura N, Kuwano Y, Okochi H, Takahashi Y, Tamaki K, Sato S, Tedder TF, Fujimoto M.
- Journal Title
  
  J Immunol 184
  
  Pages: 4637-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Differential phosphorylation of functional tyrosines in CD19 modulates B lymphocyte activation.2010
- Author(s)
  Ishiura N, Nakashima H, Watanabe R, Kuwano Y, Adachi T, Takahashi Y, Tsubata T, Okochi H, Tamaki K, Tedder TF, Fujimoto M.
- Journal Title
  
  Eur J Immunol 40
  
  Pages: 1192-1204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis.2010
- Author(s)
  Odaka M, Hasegawa M, Hamaguchi Y, Ishiura N, Kumada S, Matsushita T, Komura K, Sato S, Takehara K, Fujimoto M.
- Journal Title
  
  Clin Exp Immunol. 159
  
  Pages: 176-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] RhoH plays critical roles in FcεRI-dependent signal transduction in mast cells.2009
- Author(s)
  Oda H, Fujimoto M, Patrick MS, Chida D, Sato Y, Azuma Y, Aoki H, Abe T, Suzuki H, Shirai M.
- Journal Title
  
  J Immunol. 182
  
  Pages: 957-962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mice models of systemic sclerosis.2009
- Author(s)
  Hasegawa M, Matsushita Y, Horikawa M, Higashi K, Tomigahara Y, Kaneko H, Shirasaki F, Fujimoto M, Takehara K, Sato S.
- Journal Title
  
  Arthritis Rheum 60
  
  Pages: 3465-3475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive Arthus reaction.2009
- Author(s)
  Ishii T, Fujita T, Matsushita T, Yanaba K, Hasegawa M, Nakashima H, Ogawa F, Shimizu K, Takehara K, Tedder TF, Sato S, Fujimoto M.
- Journal Title
  
  Am J Pathol. 174
  
  Pages: 2225-2233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand.2009
- Author(s)
  Tomita H, Iwata Y, Ogawa F, Komura K, Shimizu K, Yoshizaki A, Hara T, Muroi E, Yanaba K, Bae S, Takenaka M, Hasegawa M, Fujimoto M, Sato S.
- Journal Title
  
  J Invest Dermatol 129
  
  Pages: 2059-2067
- NAID
  120001945553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.2009
- Author(s)
  Iwata Y, Yoshizaki A, Komura K, Shimizu K, Ogawa F, Hara T, Muroi E, Bae S, Takenaka M, Yukami T, Hasegawa M, Fujimoto M, Tomita Y, Tedder TF, Sato S.
- Journal Title
  
  Am J Pathol. 175
  
  Pages: 649-660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Neutralizing monoclonal antibody to human connective tissue growth facfor ameliorates transforming growth factor-β-induced mouse fibrosis2008
- Author(s)
  Ikawa Y, POH-SING NG, Endo K, Kondo M, Chujo S, Ishida W, Shirasaki F, Fujimoto M, Takehara K
- Journal Title
  
  J Cellular Physiol掲載(発行)確定 14(in press)
  
  Pages: 680-687
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591240
[Journal Article] CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.2008
- Author(s)
  Yoshizaki A, Iwata Y, Komura K, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S.
- Journal Title
  
  Am J Pathol 172
  
  Pages: 1650-1663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.2008
- Author(s)
  Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, Ogawa F, Shimizu K, Hasegawa M, Takehara K, Sato S.
- Journal Title
  
  Ann Rheum Dis 67
  
  Pages: 867-872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] A regulatory B cell subset with a unique CD1dhighCD5+ phenotype controls T cell-dependent inflammatory responses2008
- Author(s)
  Yanaba K, Bouaziz J-D, Hass KM, Poe JC, Fujimoto M, Tedder TF
- Journal Title
  
  Immunity 28
  
  Pages: 639-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse2008
- Author(s)
  Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, Ogawa F, Shimizu K, Hasegawa M, Takehara K, Sato S
- Journal Title
  
  Ann Rheum Dis 67
  
  Pages: 867-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] Regulatory B cells inhibit EAE initiation while other B cells promote disease progression.2008
- Author(s)
  Matsushita T, Yanaba K, Bouaziz J-D, Fujimoto M, Tedder TF.
- Journal Title
  
  J Clin Invest 118
  
  Pages: 3420-3430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] A regulatory B cell subset with a unique CD1d^<high>CD5^+ phenotype controls T cell-dependent inflammatory responses.2008
- Author(s)
  Yanaba K, Bouaziz J-D, Hass KM, Poe JC, Fujimoto M, Tedder TF.
- Journal Title
  
  Immunity 28
  
  Pages: 639-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591339
[Journal Article] BAFF agonist attenロates the development of skin fibrosis in Thight-skin mice.2007
- Author(s)
  Matsushita T, Fujimoto M, et. al.
- Journal Title
  
  J Invest Dermatol 127
  
  Pages: 2772-2780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Serum chemokine profile in patients with bullous pemphigioid.2007
- Author(s)
  Nakashima H, Fujimoto M, et. al.
- Journal Title
  
  British Journal of Dermatology 156
  
  Pages: 454-459
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] CD19 expression in B cells is important for suppression of contact hypersensitivity2007
- Author(s)
  Watanabe R, Fujimoto M, et. al.
- Journal Title
  
  Am J Pathol 171
  
  Pages: 560-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] CD19 expression in B cells is important for suppression of contact hypersensitivity.2007
- Author(s)
  Watanabe R, Fujimoto M, et. al.
- Journal Title
  
  Am J Pathol 171
  
  Pages: 560-570
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Phase-Dependent Roles of E-selectin during Chlonic Contact Hypelsensitivity Responses2007
- Author(s)
  Fujita T, Fujimoto M, et. al.
- Journal Title
  
  Am J Pathol 170
  
  Pages: 1649-1658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Identification of a novel autoantibody reactive with 155-and140-kDa nuclear proteins in patients with dermatomyositis : an association with malignancy2007
- Author(s)
  Kaji, K., Fujimoto, M., et. al.
- Journal Title
  
  Rheumatology 46
  
  Pages: 25-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Identification of anovel autoantibody reactive with 155-and 140-kDa nuclear proteins in patients with dermatomyositis: an association with malignancy.2007
- Author(s)
  Kaji K, Fujimoto M, et. al.
- Journal Title
  
  Rheumatology 46
  
  Pages: 25-28
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Phase-Dependent Roles of E-selectin during Chronic Contact Hypersensitivity Responses2007
- Author(s)
  Fujita, T., Fujimoto, M., et. al.
- Journal Title
  
  Am J Pathol 170
  
  Pages: 1649-1658
- NAID
  120001138017
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Serum chemokine profile in patients with bullous pemphigioid.2007
- Author(s)
  Nakashima H., Fujimoto M, et al.
- Journal Title
  
  British Journal of Dermatology 156
  
  Pages: 454-459
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Phase-Dependent Roles of E-selectin during Chronic Contact Hypelsensitivity Responses.2007
- Author(s)
  Fujita T, Fujimoto M, et. al.
- Journal Title
  
  Am J Pathol 170
  
  Pages: 1649-1658
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] BAFF antagonist attenuates the development of skin fibrosis in Tight-skin mice2007
- Author(s)
  Matsushita, T., Fujimoto, M., et. al.
- Journal Title
  
  J Invest Dermatol 127
  
  Pages: 2772-2780
- NAID
  120005756483
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] CD19 expression in B cells is important for suppression of contact hypersensitivity2007
- Author(s)
  Watanabe, R., Fujimoto, M., et. al.
- Journal Title
  
  Am J Pathol 171
  
  Pages: 560-570
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Identification of a novel autoantibody reactive with 155-and 140-kDa nuclear proteins in patients with dermatomysitis : an association with malignancy.2007
- Author(s)
  Kaji K., fujimoto M, et al.
- Journal Title
  
  Rheumatology 46
  
  Pages: 25-28
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Serum chemokine profile in patients with bullous pemphigioid2007
- Author(s)
  Nakashima, H., Fujimoto, M., et. al.
- Journal Title
  
  British Journal of Dermatology 156
  
  Pages: 454-459
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] BAFF antagonist attenuates the development of skin fibrosis om Tight-skin mice.2007
- Author(s)
  Matsushita T, Fujimoto M, et. al.
- Journal Title
  
  J Invest Dermatol 127
  
  Pages: 2772-2780
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] E-and P-synergistically inhibit bleomycin-Induced pulmonary fibrosis.2006
- Author(s)
  Horikawa M., Fujimoto M, et al.
- Journal Title
  
  American Journal of Pathology 169
  
  Pages: 740-749
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Serum levels of B cell activator of the TNF family (BAFF) are increased in bullous pemphigoid but not in pemphigus vulgaris2006
- Author(s)
  Asashima, N., Fujimoto, M., et. al.
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 330-336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.2006
- Author(s)
  Fujimoto M, Kuwano Y, Watanabe R, Asashima N ほか
- Journal Title
  
  Journal of Immunology 176・2
  
  Pages: 873-879
- Data Source
  KAKENHI-PROJECT-16790623
[Journal Article] Serum levels of B cell activator of the TNF family(BAFF) are increased in bullous pemphigoid but not in pemphigus vulgaris.2006
- Author(s)
  Asashima N, Fujimoto M, et al.
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 330-336
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] E-and P-selectins synergistically inhibit bleomycin-Induced pulmonary fibrosis2006
- Author(s)
  Horikawa, M., Fujimoto, M., et. al.
- Journal Title
  
  American Journal of Pathology 169
  
  Pages: 740-749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] E-and P-selectins synergistically inhibit bleomycin-Induced pulmonary fibrosis.2006
- Author(s)
  Horikawa M, Fujimoto M, et. al.
- Journal Title
  
  American Journal of Pathology 169
  
  Pages: 740-749
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591239
[Journal Article] Neutralizing monoclonal antibody to human connective tissue growth facfor ameliorates transforming growth factor-β-induced mouse fibrosis
- Author(s)
  Ikawa Y, POH-SING NG, Endo K, Kondo M, Chujo S, Ishida W, Shirasaki F, Fujimoto M, Takehara K
- Journal Title
  
  Journal of Cellular Physiology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591240
[Journal Article] Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor B-induced mouse fibrosis
- Author(s)
  Ikawa, Y., POH-SING, NG, Endo, K., Kondo, M., Chujo, S., WATARU, Shirasaki, F., Fujimoto, M., Takehara, K
- Journal Title
  
  Journal of Cellular Physiology (in print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Regulatory B cells in skin disease2013
- Author(s)
  Fujimoto M
- Organizer
  International Meeting of Investigative Dermatology
- Place of Presentation
  Edinburgh, UK
- Year and Date
  2013-05-10
- Data Source
  KAKENHI-PROJECT-23390281
[Presentation] Neutralizing antibody to human connective tissue growth factor ameliorates transforming growth factor-β induced mouse fibrosis model2007
- Author(s)
  Ikawa Y, Kondo M, Chujo S, Shirasaki F, Fujimoto M, Ng Poh-Sing, Takehara K
- Organizer
  Professor E. Carwaile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  Tokyo
- Year and Date
  2007-05-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Neutralizing antibody to human connective tissue growth factor ameliorates transforming growth factor induced mouse fibrosis model2007
- Author(s)
  Ikawa, Y., Ng, Poh-Sing, Miyazaki, M., Chujo, S., Ishida, W., Shirasaki, F., Fujimoto, M., Takehara, K
- Organizer
  Japan CCN family Society
- Place of Presentation
  Okayama
- Year and Date
  2007-10-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] TGF一βで誘導されるモデルマウスの線維化が抗CTGF抗体で抑制された2007
- Author(s)
  伊川友香, 松下幸世, 近藤美幾, 藤本晃英, 長谷川稔, 竹原和彦, 刀祢裕美, 和田泰三, 谷内江昭宏
- Organizer
  第1回日本CCNファミリー研究会
- Place of Presentation
  岡山市
- Year and Date
  2007-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Neutralizing antibody to human connective tissue growth factor ameliorates transforming growth factor-β induced mouse fibrosis model2007
- Author(s)
  Ikawa Y, Kondo M, Chujo S, Shirasaki F, Fujimoto M, NgPoh-Sing, Takehara K
- Organizer
  Professor E.Carwaile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  Tokyo
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] TGF-βで誘導されるモデルマウスの線維化が抗CTGF抗体で抑制された2007
- Author(s)
  伊川友香, 松下幸世, 近藤美幾藤本晃英, 長川稔, 竹原和彦, 刀祢裕美, 和田泰三, 谷内江昭宏
- Organizer
  第1回日本CCNファミリ-研究会
- Place of Presentation
  岡山市
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18591240

1. TAKEHARA Kazuhiko (50142253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. SHIRASAKI Fumiaki (10313644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. CHUJO Sonoko (20401911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 佐藤伸一 (20215792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKIYAMA Naoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. MATSUSHITA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. Tadokoro Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. Kobayashi Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Ueno Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 長谷川稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
11. 石塚洋典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 桑名正隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 平尾敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 仲一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

fujimoto manabu 藤本 学

FUJIMOTO Manabu 藤本 学

藤本 学 フジモト マナブ

Research Projects

Research Products

Co-Researchers

皮膚筋炎特異的自己抗原に対する免疫応答が皮膚筋炎の病態を形成する分子機序の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

B cell and autoantibody in the pathogenesis of dermatomyositisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Development of therapy for skin diseases by utilizing regulatory B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of new regulatory B cell subsets suppressing fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of regulatory B cell inhibition on skin immunological diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of marker molecules specific for regulatory B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

制御性B細胞の機能解析と自己免疫疾患の抑制機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of regulatory B cells in immuno-dermatological diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Developmentoftherapies for autoimmune diseases by targeting B cellsignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The inhibition by anti-CTGF antibody produced by the DNA immunization method in the cytokine induced skin fibrosis model mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

免疫担当細胞におけるCD83の機能と皮膚疾患との関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation of the mechanisms of upregulated collagen production of cytokine-induced skin fibrosis model.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CD19によるB細胞活性化シグナルの制御メカニズムPrincipal Investigator

Principal Investigator

fujimoto manabu 藤本学

FUJIMOTO Manabu 藤本学

藤本学フジモトマナブ