KONDO Naohide 近藤直英

Researcher Number	20725527
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2016: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator 分子シャペロン / Hsp70 / CpGアイランド / 運動ニューロン疾患 / 神経変性疾患 / DNAメチル化阻害剤 / DNAメチル化酵素 / DNAメチル化 / エピジェネティクス / 球脊髄性筋萎縮症 … More Except Principal Investigator … More 筋萎縮性側索硬化症 / 呼吸機能 / バイオマーカー / シスタチンC / 運動ニューロン疾患 / シグナル / リン酸化 / 神経変性疾患 / プロテオーム / シグナル伝達 / 神経科学 / 脳神経疾患 / DNAメチル化 / Aktシグナル / 球脊髄性筋萎縮症 / NFkB / ミトコンドリア / エピジェネティクス / 骨格筋 / 運動ニューロン Less

Development of biomarker and therapy for amyotrophic lateral sclerosis targeting cystatin C
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Therapy development for neuromuscular degeneration in motor neuron diseases
- Principal Investigator
  
  KATSUNO Masahisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Epigenetic mechanism on the pathogenesis of motor neuron diseasePrincipal Investigator
- Principal Investigator
  
  Kondo Naohide
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University

All 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] Heat Shock Factor, Chapter11 HSF Inhibits the Progression of Age-Related Neurodegenerative Diseases2016
- Author(s)
  Nakai Akira (Ed.), Chapter11 Kondo Naohide, Katsuno Masahisa, Riku Yuichi,Sobue Gen
- Total Pages
  292
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26860665
[Journal Article] Decreased Peak Expiratory Flow Associated with Muscle Fiber-Type Switching in Spinal and Bulbar Muscular Atrophy.2016
- Author(s)
  Yamada S, Hashizume A, Hijikata Y, Inagaki T, Suzuki K, Kondo N, Kawai K, Noda S, Nakanishi H, Banno H, Hirakawa A, Koike H, Halievski K, Jordan CL, Katsuno M, Sobue G.
- Journal Title
  
  PLoS One.
  
  Volume: 11(12) Issue: 12 Pages: e0168846-e0168846
- DOI
  10.1371/journal.pone.0168846
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26461269, KAKENHI-PROJECT-16K15480
[Journal Article] BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degeneration through the activation of heat shock factor 1.2016
- Author(s)
  Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G
- Journal Title
  
  Neuroscience
  
  Volume: S0306-4522 Pages: 30051-30053
- DOI
  10.1016/j.neuroscience.2016.03.064
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860665, KAKENHI-PROJECT-26293207, KAKENHI-PROJECT-15K19482
[Journal Article] Hemodialysis-related Portal-Systemic Encephalopathy2015
- Author(s)
  Kondo N, Ito Y, Yamashita H, Azuma F, Nokura K, Yasuda T, Sobue G
- Journal Title
  
  Intern. Med.
  
  Volume: 54 Issue: 9 Pages: 1113-1117
- DOI
  10.2169/internalmedicine.54.0267
- NAID
  130005068313
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860665
[Journal Article] Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.2015
- Author(s)
  Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24(21) Issue: 21 Pages: 5985-94
- DOI
  10.1093/hmg/ddv300
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461268, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26860665, KAKENHI-PROJECT-26293206
[Journal Article] Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.2015
- Author(s)
  Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 2 Pages: 314-329
- DOI
  10.1093/hmg/ddu445
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22110005, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26670440, KAKENHI-PROJECT-26860665, KAKENHI-PROJECT-26293206, KAKENHI-PLANNED-26117002
[Journal Article] Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration.2015
- Author(s)
  Ding Y, Adachi H, Katsuno M, Huang Z, Jiang YM, Kondo N, Iida M, Tohnai G, Nakatsuji H, Funakoshi H, Nakamura T, Sobue G
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 468 Issue: 4 Pages: 677-683
- DOI
  10.1016/j.bbrc.2015.11.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26860665
[Journal Article] Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy.2014
- Author(s)
  Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 23 Issue: 13 Pages: 3552-3565
- DOI
  10.1093/hmg/ddu066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110005, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26670440, KAKENHI-PROJECT-26860665, KAKENHI-PLANNED-26117002
[Presentation] Dysregulated Akt signaling pathway in spinal and bulbar muscular atrophy (SBMA)2016
- Author(s)
  飯田円，勝野雅央，佐橋健太郎，中辻秀朗，近藤直英，藤内玄規，祖父江元
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県　横浜市)
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] 神経変性疾患モデルにおけるタクロリムスとその誘導体の治療効果2016
- Author(s)
  藤内玄規, 勝野雅央, 足立弘明, 佐橋健太郎, 近藤直英, 中辻秀朗, 飯田円, 祖父江元
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県　横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] The effect of exercise in a mouse model of spinal and bulbar muscular atrophy.2016
- Author(s)
  中辻秀朗, 勝野雅央, 近藤直英, 藤内玄規, 佐橋健太郎, 飯田円, 祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県　神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Dysregulated Akt signaling pathway in spinal and bulbar muscular atrophy (SBMA).2016
- Author(s)
  飯田円，勝野雅央，佐橋健太郎，中辻秀朗，近藤直英，藤内玄規，祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県　神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Dissection of mechanisms of neuronal degeneration in polyglutamine disease.2016
- Author(s)
  佐橋健太郎, 近藤直英, 中辻秀朗, 藤内玄規, 飯田円, 勝野雅央, 祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県　神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Role of aberrant DNA methylation in the pathogenesis of spinal and bulbar muscular atrophy.2016
- Author(s)
  Kondo N, Katsuno M, Adachi H, Sahashi K, Iida M, Nakatsuji H, Tohnai G, Sobue G.
- Organizer
  第8回NAGOYAグローバルリトリート
- Place of Presentation
  あいち健康プラザ(愛知県知多郡)
- Year and Date
  2016-02-12
- Data Source
  KAKENHI-PROJECT-26860665
[Presentation] The effects of pioglitazone on spinal and bulbar muscular atrophy.2015
- Author(s)
  Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Watanabe H, Yamamoto M, Kishida K, Sobue G.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県新潟市)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Dysregulated nuclear factor-κB (NFκB) signaling in spinal and bulbar muscular atrophy (SBMA).2015
- Author(s)
  Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Tohnai G, Sobue G.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市)
- Year and Date
  2015-07-26
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Cell cycle inhibitor ameliorates motor neuron degeneration induced by polyglutamine-expanded androgen receptor.2015
- Author(s)
  Katsuno M, Adachi H, Sahashi K, Kondo N, Iida M, Nakatsuji H, Tohnai G, Sobue G.
- Organizer
  The 26th International Symposium on ALS/MND
- Place of Presentation
  Orland, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] 球脊髄性筋萎縮症モデルにおけるタクロリムス誘導体の治療効果2015
- Author(s)
  藤内玄規, 足立弘明, 勝野雅央, 佐橋健太郎, 近藤直英, 中辻秀朗, 飯田円, 祖父江元.
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Epigenetic treatment of polyglutamine-induced motor neuron disease.2015
- Author(s)
  Kondo N, Katsuno M, Adachi H, Sahashi K, Iida M, Nakatsuji H, Tohnai G, Sobue G.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県新潟市)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26860665
[Presentation] Expression and role of TFEB in spinal and bulbar muscular atrophy2015
- Author(s)
  藤内玄規, 足立弘明, 勝野雅央, 近藤直英, 宮崎雄, 飯田円, 中辻秀朗, 丁瑩, 渡辺宏久, 祖父江元.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県新潟市)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] DNAメチル化阻害剤(RG108)による遺伝性運動ニューロン疾患治療2015
- Author(s)
  近藤直英、勝野雅央、足立弘明、佐橋健太郎、飯田円、中辻秀朗、藤内玄規、祖父江元
- Organizer
  第5回名古屋大学・生理学研究所合同シンポジウム
- Place of Presentation
  生理学研究所(愛知県岡崎市)
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-26860665
[Presentation] DNAメチル化阻害剤による球脊髄性筋萎縮症の治療法開発2015
- Author(s)
  近藤直英、勝野雅央、足立弘明、佐橋健太郎、飯田円、中辻秀朗、藤内玄規、祖父江元
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26860665
[Presentation] Intracerebroventricular administration of antisense oligonucleotides improves disease phenotypes in SBMA mice.2015
- Author(s)
  Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県新潟市)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Antisense inhibition of neuronal androgen receptor in spinal and bulbar muscular atrophy.2015
- Author(s)
  Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Role of aberrant DNA methylation in the pathogenesis of spinal and bulbar muscular atrophy
- Author(s)
  近藤直英，勝野雅央，佐橋健太郎，飯田円，中辻秀朗，藤内玄規，祖父江元
- Organizer
  第7回NAGOYAグローバルリトリート
- Place of Presentation
  愛知県大府市(愛知健康プラザ)
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-26860665
[Presentation] DNAメチル化阻害剤が球脊髄性筋萎縮症の病態に与える影響の解析
- Author(s)
  近藤直英，勝野雅央，足立弘明，佐橋健太郎，飯田円，中辻秀朗，藤内玄規，祖父江元
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡県福岡市(福岡国際会議場・福岡サンパレス・福岡国際センター)
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26860665

1. KATSUNO Masahisa (50402566)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. Sobue Gen (20148315)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
3. Sahashi Kentaro (90710103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. OKADA Yohei (30383714)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ADACHI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. Bennett C. Frank

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KONDO Naohide 近藤 直英

Research Projects

Research Products

Co-Researchers

Development of biomarker and therapy for amyotrophic lateral sclerosis targeting cystatin C

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapy development for neuromuscular degeneration in motor neuron diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetic mechanism on the pathogenesis of motor neuron diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Heat Shock Factor, Chapter11 HSF Inhibits the Progression of Age-Related Neurodegenerative Diseases2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Decreased Peak Expiratory Flow Associated with Muscle Fiber-Type Switching in Spinal and Bulbar Muscular Atrophy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degeneration through the activation of heat shock factor 1.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hemodialysis-related Portal-Systemic Encephalopathy2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Dysregulated Akt signaling pathway in spinal and bulbar muscular atrophy (SBMA)2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 神経変性疾患モデルにおけるタクロリムスとその誘導体の治療効果2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The effect of exercise in a mouse model of spinal and bulbar muscular atrophy.2016

Author(s)

Organizer

KONDO Naohide 近藤直英