YAMAMURO DAISUKE 山室大介

Researcher Number	20739255
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2025: 明治薬科大学, 薬学部, 助教 2018 – 2022: 自治医科大学, 医学部, リサーチ・レジデント 2015 – 2017: 自治医科大学, 医学部, リサーチレジデント
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / General pharmacology Except Principal Investigator Metabolomics
Keywords	Principal Investigator NCEH1 / オキシステロール / 小胞体ストレス / 25-Hydroxycholesterol / アポトーシス / 25-hydroxycholesterol / 脂質代謝異常 / ACAT1阻害剤 / NCEH1阻害剤 / ACAT1 … More / アルツハイマー型認知症 / 24S-ヒドロキシコレステロール / Aβ / 24S-HC / アミロイドβ / アルツハイマー … More Except Principal Investigator エステル / アポトーシス / 小胞体 / 脂肪酸 / 加水分解 / 酵素 / オキシステロール / 小胞体ストレス / マウス / トランスジェニック / リパーゼ / コレステロール / マクロファージ / 泡沫細胞 / 動脈硬化 Less

脂肪組織における25-Hydroxycholesterolの生理機能の解明Principal Investigator
- Principal Investigator
  
  山室大介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Meiji Pharmaceutical University
Elucidation of the apotosis mechanism induced by 25-HC ester and analysis of its effects on cellular functionsPrincipal Investigator
- Principal Investigator
  
  Yamamuro Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Jichi Medical University
Analysis of Alzheimer's disease induced by abnormal cholesterol metabolismPrincipal Investigator
- Principal Investigator
  
  YAMAMURO DAISUKE
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Jichi Medical University
Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University

All 2021 2015 2014

All Journal Article Presentation

[Journal Article] Esterification of 4-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT2021
- Author(s)
  Daisuke Yamamuro , Hisataka Yamazaki , Jun-Ichi Osuga , Kenta Okada , Tetsuji Wakabayashi , Akihito Takei , Shoko Takei , Manabu Takahashi , Shuichi Nagashima , Adriaan G Holleboom , Masayuki Kuroda , Hideaki Bujo , Shun Ishibashi
- Journal Title
  
  The Journal of Lipid Research
  
  Volume: 61 Pages: 1287-1299
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17519
[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 56 Issue: 5 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Presentation] 脂質代謝の概日リズムと摂餌刺激2021
- Author(s)
  山室大介
- Organizer
  日本動脈硬化学会
- Data Source
  KAKENHI-PROJECT-20K17519

1. ISHIBASHI SHUN (90212919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. NAGASHIMA SHUICHI (30406136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. TAKAHASHI MANABU (70406122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 坂井謙斗 (30646352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 大須賀淳一 (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

YAMAMURO DAISUKE 山室 大介

Research Projects

Research Products

Co-Researchers

脂肪組織における25-Hydroxycholesterolの生理機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the apotosis mechanism induced by 25-HC ester and analysis of its effects on cellular functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Alzheimer's disease induced by abnormal cholesterol metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Esterification of 4-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT2021

Author(s)

Journal Title

Data Source

[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脂質代謝の概日リズムと摂餌刺激2021

Author(s)

Organizer

Data Source

YAMAMURO DAISUKE 山室大介