Araiso Yuhei 荒磯裕平

Researcher Number	20753726
Other IDs
Affiliation (Current)	2026: 金沢大学, 保健学系, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 金沢大学, 保健学系, 准教授 2020 – 2022: 金沢大学, 保健学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 28040:Nanobioscience-related / Medium-sized Section 28:Nano/micro science and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 52010:General internal medicine-related / Basic Section 44010:Cell biology-related
Keywords	Principal Investigator 高速原子間力顕微鏡 / ミトコンドリア / 膜タンパク質複合体 / TOM複合体 / タンパク質輸送 / GTPase / リン脂質 / １分子観察 / 膜タンパク質 / GFP … More / クライオ電子顕微鏡 / タンパク質複合体 / Cryo-EM / HS-AFM / １分子イメージング / 膜透過装置 / 前駆体タンパク質 … More Except Principal Investigator グラム陰性菌 / タンパク質輸送装置 / TOM複合体 / BAM複合体 / QCMーD / 高速原子間力顕微鏡 / 中性子反射率法 / 大気汚染 / タンパク質構造 / 神経変性疾患 / 認知症 / ナノ粒子 / 分子イメージング / ミオグロビン / タンパク質輸送 / ミトコンドリア / 筋細胞 / VTE / 静脈血栓塞栓症 / パネル検査 / 高速原子力間顕微鏡 / NGSパネル検査 / 原子力間顕微鏡（AFM） / ノックアウトゼブラフィッシュ / Liposome flotation assay / 原子間力顕微鏡（AFM） / 遺伝子パネル検査 / プロテインS（PS）欠乏症 / プロテインC(PC)欠乏症 / アンチトロンビン（AT）欠乏症 / 遺伝性血栓症 / 転写調節因子E2F / Rbがん抑制タンパク / サイクリン / プロテインホスファターゼ / IER2タンパク / Rbがん抑制遺伝子 / 細胞運動 / 細胞周期 / E2F転写調節因子 / RBがん抑制遺伝子 / IERタンパク / PP2Aアダプタータンパク / Protein phosphatase 2A Less

Mechanism of Dementia Risk Induced by Ultrafine Particles: Structural Protein Abnormalities Triggered by Particle Surfaces
- Principal Investigator
  
  小野田淳人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Tokyo University of Science, Yamaguchi
Visualization of molecular machineries regulating mitochondrial outer membrane fission and fusion at the single-molecule levelPrincipal Investigator
- Principal Investigator
  
  荒磯裕平
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Kanazawa University
Elucidation of the precise protein transport mechanism regulated by the "heterogeneous" translocase of the outer mitochondrial membranePrincipal Investigator
- Principal Investigator
  
  荒磯裕平
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kanazawa University
Mechanisms of cellular functional modification induced by unconventional proteins transported to mitochondria in myocyte
- Principal Investigator
  
  増田和実
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kanazawa University
Analysis of super complex of protein translocators using multiple biophysical approaches
- Principal Investigator
  
  塩田拓也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  University of Miyazaki
Elucidating the Pathophysiology of Hereditary Thrombophilia through Integrated Omics Approaches
- Principal Investigator
  
  Morishita Eriko
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kanazawa University
Establishment of GFP tracking method for real-time analysis of protein complex behaviorPrincipal Investigator
- Principal Investigator
  
  Araiso Yuhei
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kanazawa University
Regulation of signal transduction and cell growth by protein phosphatase 2A
- Principal Investigator
  
  Sakurai Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kanazawa University
Dynamic analysis of precursor proteins passing through the translocase of the mitochondrial outer membrane complexPrincipal Investigator
- Principal Investigator
  
  Araiso Yuhei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kanazawa University

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Mechanism of antithrombin deficiency due to the novel variant C32W in the C-terminus of the signal peptide2025
- Author(s)
  Kikuchi Y, Nagaya S, Togashi T, Imai Y, Togashi M, Araiso Y, Nishiuchi T, Morishita E
- Journal Title
  
  International Journal of Hematology
  
  Volume: - Issue: 1 Pages: 35-44
- DOI
  10.1007/s12185-025-03945-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07391, KAKENHI-PROJECT-24K18661, KAKENHI-PROJECT-24KJ1186
[Journal Article] Large-scale purification of mitochondrial protein complexes in yeast expression system for structural analyses2024
- Author(s)
  Kobayashi Nanako、Imai Yuta、Kita Shintaro、Kawai Shiho、Araiso Yuhei
- Journal Title
  
  Methods in Enzymology
  
  Volume: 707 Pages: 367-388
- DOI
  10.1016/bs.mie.2024.07.043
- ISBN
  9780443314704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K26507
[Journal Article] Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics2023
- Author(s)
  Imai Yuta、Nagaya Satomi、Araiso Yuhei、Meguro-Horike Makiko、Togashi Tomoki、Horike Shin-ichi、Kawasaki Hiroshi、Morishita Eriko
- Journal Title
  
  Thrombosis Research
  
  Volume: 230 Pages: 18-26
- DOI
  10.1016/j.thromres.2023.08.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06896, KAKENHI-PROJECT-22K07391, KAKENHI-PROJECT-21K19306, KAKENHI-PROJECT-22K15663, KAKENHI-PROJECT-20H03338, KAKENHI-PROJECT-23H00389
[Journal Article] Role of the TOM complex in Protein Import into Mitochondria: Structural Views2022
- Author(s)
  Yuhei Araiso, Kenichiro Imai, Toshiya Endo
- Journal Title
  
  Annual Review of Biochemistry
  
  Volume: 91 Issue: 1 Pages: 679-703
- DOI
  10.1146/annurev-biochem-032620-104527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02583, KAKENHI-PROJECT-20H05689, KAKENHI-PROJECT-21H03551, KAKENHI-PLANNED-20H05929
[Journal Article] Structural overview of the translocase of the mitochondrial outer membrane complex2022
- Author(s)
  Araiso Y, Imai K, Endo
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 19 Issue: 0 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v19.0022
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05705, KAKENHI-PROJECT-20H02583, KAKENHI-PLANNED-20H05929, KAKENHI-PROJECT-20H05689
[Journal Article] Identification and functional analysis of three novel genetic variants resulting in premature termination codons in three unrelated patients with hereditary antithrombin deficiency2022
- Author(s)
  Imai Yuta、Nagaya Satomi、Araiso Yuhei、Meguro-Horike Makiko、Togashi Tomoki、Ohmori Kensho、Makita Yuka、Sato Eiichi、Yujiri Toshiaki、Nagamori Yuta、Horike Shin-ichi、Watanabe Atsushi、Morishita Eriko
- Journal Title
  
  International Journal of Hematology
  
  Volume: 117 Issue: 4 Pages: 523-529
- DOI
  10.1007/s12185-022-03509-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07391, KAKENHI-PROJECT-22K15663
[Journal Article] Structural snapshot of the mitochondrial protein import gate2021
- Author(s)
  Araiso Y, Imai K, Endo T
- Journal Title
  
  FEBS J
  
  Volume: - Issue: 18 Pages: 1-11
- DOI
  10.1111/febs.15661
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11543, KAKENHI-PUBLICLY-20H04912, KAKENHI-PROJECT-20H02583, KAKENHI-PROJECT-15H05705
[Presentation] ミトコンドリアの分裂と融合を制御する分子装置の構造とダイナミクス2025
- Author(s)
  荒磯裕平
- Organizer
  第23回膜タンパク質研究センター（MPRC）セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-24KK0138
[Presentation] Structure and dynamics of molecular machineries regulating mitochondrial morphology2025
- Author(s)
  Yuhei Araiso
- Organizer
  The 27th Plant Organelle Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26507
[Presentation] Structure and dynamics of molecular machineries regulating mitochondrial morphology2025
- Author(s)
  Yuhei Araiso
- Organizer
  The 27th Plant Organelle Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19268
[Presentation] Single molecule dynamics analysis of protein complexes that regulate mitochondrial morphology using high speed atomic force microscopy2025
- Author(s)
  Yuhei Araiso
- Organizer
  IBMP, University of Strasbourg
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24KK0138
[Presentation] Structure and dynamics of molecular machineries regulating mitochondrial morphology2025
- Author(s)
  Yuhei Araiso
- Organizer
  The 27th Plant Organelle Workshop, Oral presentation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24KK0138
[Presentation] Structure and dynamics of the translocase of the outer mitochondrial membrane complex revealed by high-speed atomic force microscopy analysis2024
- Author(s)
  Nanako Kobayashi, Kana Kuzasa, Romain Amyot, Shiho Kawai, Yuta Imai, Akihiro Inazu, Kenichiro Imai, Noriyuki Kodera, Toshiya Endo, Yuhei Araiso
- Organizer
  第24回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K26507
[Presentation] Structure and dynamics of the translocase of the outer mitochondrial membrane complex revealed by high-speed atomic force microscopy analysis2024
- Author(s)
  Nanako Kobayashi, Kana Kuzasa, Romain Amyot, Shiho Kawai, Yuta Imai, Akihiro Inazu, Kenichiro Imai, Noriyuki Kodera, Toshiya Endo, Yuhei Araiso
- Organizer
  第24回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19268
[Presentation] ミトコンドリア膜透過装置TOM複合体の一分子動態解析2024
- Author(s)
  小林菜々子、九笹加菜、Amyot Romain、川合志朋、今井湧太、今井賢一郎、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K26507
[Presentation] 出血傾向を呈するプロトロンビン異常症のリン脂質結合能評価およびリン脂質結合動態の可視化2024
- Author(s)
  西野優那, 油井陸斗, 松本陽斗, 桑島大和, 荒磯裕平, 長屋聡美, 山口有梨香, 今井湧太, 安田芽生, 魏威凛, 太村理沙, 中谷佳代, 古寺哲幸, 森下英理子
- Organizer
  第42回日本血液学会北陸地方会
- Data Source
  KAKENHI-PROJECT-22K07391
[Presentation] ミトコンドリア膜透過装置TOM複合体の一分子動態解析2024
- Author(s)
  小林菜々子、九笹加菜、Amyot Romain、川合志朋、今井湧太、今井賢一郎、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K19268
[Presentation] アンチトロンビンノックアウトゼブラフィッシュの初期胚発生過程における病態学的解析2024
- Author(s)
  今井湧太, 野田太希, 小林功, 稲津明広, 森下英理子, 荒磯裕平
- Organizer
  第46回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07391
[Presentation] 出血性異常プロトロンビンのリン脂質結合能解析およびリン脂質結合動態の可視化2024
- Author(s)
  松本陽斗, 荒磯裕平, 長屋聡美, 桑島大和, 喜多慎太郎, 今井湧太, 安田芽生, 魏威凛, 太村理沙, 古寺哲幸, 森下英理子
- Organizer
  第46回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07391
[Presentation] ミトコンドリア膜透過装置TOM複合体の一分子動態解析2024
- Author(s)
  小林菜々子、九笹加菜、Amyot Romain、川合志朋、今井湧太、今井賢一郎、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-24KK0138
[Presentation] アンチトロンビンノックアウトゼブラフィッシュの初期胚発生過程における血栓形成2023
- Author(s)
  今井湧太, 野田太希, 小林功, 稲津明広, 森下英理子, 荒磯裕平
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07391
[Presentation] ミトコンドリアタンパク質搬入ゲートTOM複合体の構造とダイナミクス2023
- Author(s)
  荒磯裕平、小林菜々子、Romain Amyot、九笹加菜、今井大達、川合志朋、今井賢一郎、稲津明広、古寺哲幸、遠藤斗志也
- Organizer
  令和４年度生物物理学会中部支部講演会（名古屋）
- Data Source
  KAKENHI-PROJECT-22K19268
[Presentation] ミトコンドリアタンパク質搬入ゲートTOM複合体の構造とダイナミクス2023
- Author(s)
  荒磯裕平、小林菜々子、Romain Amyot、九笹加菜、今井大達、川合志朋、今井賢一郎、稲津明広、古寺哲幸、遠藤斗志也
- Organizer
  令和４年度生物物理学会中部支部講演会（名古屋）
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] ミトコンドリア膜透過装置TOM複合体の一分子動態解析2023
- Author(s)
  小林菜々子、九笹加菜、 Romain Amyot 、今井大達、川合志朋、今井湧太、稲津明広、今井賢一郎、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K26507
[Presentation] Elucidating the substrate degradation mechanism of mitochondrial inner membrane AAA+ protease Yme12023
- Author(s)
  今井湧太、古寺哲幸、荒磯裕平
- Organizer
  第１回SFD国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26507
[Presentation] HS-AFM analysis of Drp1, a dynamin-like protein that regulates mitochondrial fission2023
- Author(s)
  喜多慎太郎、上谷望花、本田知也、辻本大貴、稲津明広、古寺哲幸、荒磯裕平
- Organizer
  第１回SFD国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19268
[Presentation] ミトコンドリア分裂を制御するダイナミン様タンパク質Drp1の高速原子間力顕微鏡解析2023
- Author(s)
  喜多慎太郎、本田知也、上谷望花、辻本大貴、稲津明広、古寺哲幸、荒磯裕平
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K19268
[Presentation] ミトコンドリア膜透過装置TOM複合体の高速原子間力顕微鏡解析2022
- Author(s)
  小林菜々子、九笹加菜、今井大達、川合志朋、槙野愛実、稲津明広、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第45回日本分子生物学会年会（千葉）
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] 高速原子間力顕微鏡によって明らかになったミトコンドリアタンパク質搬入ゲート TOM複合体の構造とダイナミクス2022
- Author(s)
  九笹加菜、小林菜々子、今井大達、槙野愛実、稲津明広、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第22回日本蛋白質科学会年会（筑波）
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] 高速原子間力顕微鏡解析によって明らかになったミトコンドリアタンパク質搬入ゲートTOM複合体の構造とダイナミクス2022
- Author(s)
  九笹加菜、小林菜々子、今井大達、槙野愛実、稲津明広、古寺哲幸、遠藤斗志也、荒磯裕平
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] 2つの異常バリアントから生成される異常アンチトロンビンタンパクの動態解析2022
- Author(s)
  今井湧太、長屋聡美、荒磯裕平、冨樫朋貴、大森健聖、牧田友香、伊勢美樹子、森下英理子
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07391
[Presentation] High-speed atomic force microscopy analysis of the mitochondrial import gate TOM complex2022
- Author(s)
  荒磯裕平、九笹加菜、小林菜々子、今井大達、槙野愛実、稲津明広、古寺哲幸、遠藤斗志也
- Organizer
  第60回日本生物物理学会年会（函館）
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] ミトコンドリアタンパク質搬入ゲートTOM複合体の構造とダイナミクス2022
- Author(s)
  荒磯裕平
- Organizer
  日本生化学会北陸支部会　第40回大会（富山）
- Invited
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] High-Speed atomic force microscopy analysis of the mitochondrial protein import gate TOM complex2021
- Author(s)
  Kana Kuzasa, Hirotatsu Imai, Noriyuki Kodera, Akihiro Inazu, Toshiya Endo, Yuhei Araiso
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] Structural analysis of the mitochondrial protein import gate by near-atomic resolution snapshot and nanoscale video imaging2021
- Author(s)
  Yuhei Araiso, Akihisa Tsutsumi, Kenichiro Imai, Takuya Shiota, Hirotatsu Imai, Kana Kuzasa, Noriyuki Kodera, Masahide Kikkawa, Toshiya Endo
- Organizer
  第44回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] 高速原子間力顕微鏡を用いたミトコンドリアタンパク質搬入ゲートTOM複合体の動的構造解析2021
- Author(s)
  九笹加菜、今井大達、古寺哲幸、稲津明広、遠藤斗志也、荒磯裕平
- Organizer
  日本生化学会北陸支部第39回大会
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] Structure of the mitochondrial protein import gate reveals distinct protein path2020
- Author(s)
  荒磯裕平
- Organizer
  第２０回日本蛋白質科学会年会若手奨励賞シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H02583
[Presentation] ミトコンドリアへのタンパク質搬入ゲートTOM複合体の構造と機能2020
- Author(s)
  荒磯裕平
- Organizer
  日本生体エネルギー研究会第４６回討論会
- Invited
- Data Source
  KAKENHI-PROJECT-20H02583

1. Sakurai Hiroshi (00225848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Morishita Eriko (50251921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 小原收 (20370926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 増田和実 (50323283)

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5. 芝口翼 (40785953)

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6. 新井敏 (70454056)

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7. 小野田淳人 (70835389)

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8. 梅澤雅和 (60615277)

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9. 石原康宏 (80435073)

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10. 塩田拓也 (20819304)

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11. 宮崎亮次 (30827564)

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12. 青木英莉子 (80822874)

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13. IMAI Kenichiro

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14. HORIKE Shinichi

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# of Collaborated Products: 1 results

Araiso Yuhei 荒磯 裕平

Research Projects

Research Products

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Mechanism of Dementia Risk Induced by Ultrafine Particles: Structural Protein Abnormalities Triggered by Particle Surfaces

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Visualization of molecular machineries regulating mitochondrial outer membrane fission and fusion at the single-molecule levelPrincipal Investigator

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Elucidation of the precise protein transport mechanism regulated by the "heterogeneous" translocase of the outer mitochondrial membranePrincipal Investigator

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Mechanisms of cellular functional modification induced by unconventional proteins transported to mitochondria in myocyte

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Analysis of super complex of protein translocators using multiple biophysical approaches

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Elucidating the Pathophysiology of Hereditary Thrombophilia through Integrated Omics Approaches

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Establishment of GFP tracking method for real-time analysis of protein complex behaviorPrincipal Investigator

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Regulation of signal transduction and cell growth by protein phosphatase 2A

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Dynamic analysis of precursor proteins passing through the translocase of the mitochondrial outer membrane complexPrincipal Investigator

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[Journal Article] Mechanism of antithrombin deficiency due to the novel variant C32W in the C-terminus of the signal peptide2025

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[Journal Article] Large-scale purification of mitochondrial protein complexes in yeast expression system for structural analyses2024

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[Journal Article] Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics2023

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[Journal Article] Role of the TOM complex in Protein Import into Mitochondria: Structural Views2022

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[Journal Article] Structural overview of the translocase of the mitochondrial outer membrane complex2022

Araiso Yuhei 荒磯裕平