Tsuchihashi Kenji 土橋賢司

Researcher Number	20773675
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2025: 九州大学, 大学病院, 助教 2017 – 2022: 九州大学, 大学病院, 助教 2016: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Tumor therapeutics
Keywords	Principal Investigator EGFR / グルタミン酸 / xCT / 脳腫瘍 / 融合遺伝子 / 肉腫 / cancer / immune escape / epitranscriptome / Immune checkpoint … More / RNA modification / Epitranscriptome / 免疫チェックポイント分子 / 大腸がん / エピトランスクリプトーム / N6メチルアデノシン / FTO / PD-L1 / がん幹細胞 / NMDA / 上皮成長因子受容体 / NMDA受容体 / グルタミン酸受容体 / Glioma / Glutamate / 還元型グルタチオン / グルタチオン / 酸化ストレス Less

Development of a targeted therapy for fusion genes in sarcomaPrincipal Investigator
- Principal Investigator
  
  土橋賢司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyushu University
The role of epitranscriptome on immune escape in cancerPrincipal Investigator
- Principal Investigator
  
  Tsuchihashi Kenji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
Elucidating the role of glutamate in xCT-expressing cancer cellsPrincipal Investigator
- Principal Investigator
  
  Tsuchihashi Kenji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
Development of therapeutic strategry breaking resistance to oxidative stress in gliomaPrincipal Investigator
- Principal Investigator
  
  Tsuchihashi Kenji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022
- Author(s)
  Tsuchihashi Kenji、Hirata Yuki、Yamasaki Juntaro、Suina Kentaro、Tanoue Kenro、Yae Toshifumi、Masuda Kenta、Baba Eishi、Akashi Koichi、Kitagawa Yuko、Saya Hideyuki、Nagano Osamu
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 30 Pages: 101246-101246
- DOI
  10.1016/j.bbrep.2022.101246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21H02766, KAKENHI-PROJECT-20K07638, KAKENHI-PROJECT-21K19417, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K18174
[Journal Article] RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells2020
- Author(s)
  Tsuruta Nobuhiro、Tsuchihashi Kenji、Ohmura Hirofumi、Yamaguchi Kyoko、Ito Mamoru、Ariyama Hiroshi、Kusaba Hitoshi、Akashi Koichi、Baba Eishi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 1 Pages: 235-239
- DOI
  10.1016/j.bbrc.2020.06.153
- Data Source
  KAKENHI-PROJECT-20K07638
[Journal Article] Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension2019
- Author(s)
  Isobe Sarasa、Kataoka Masaharu、Endo Jin、Moriyama Hidenori、Okazaki Shogo、Tsuchihashi Kenji、Katsumata Yoshinori、Yamamoto Tsunehisa、Shirakawa Kohsuke、Yoshida Naohiro、Shimoda Masayuki、Chiba Tomohiro、Masuko Takashi、Hakamata Yoji、Kobayashi Eiji、Saya Hideyuki、Fukuda Keiichi、Sano Motoaki
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: Volume61,Issue3 Issue: 3 Pages: 367-379
- DOI
  10.1165/rcmb.2018-0231oc
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02812, KAKENHI-PROJECT-18K15215, KAKENHI-PROJECT-18K15223
[Journal Article] EGFR promotes glioma progression by regulating xCT and GluN2B-containing NMDA receptor signaling.2018
- Author(s)
  Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, Okazaki S, Sampetrean O, Baba E, Akashi K, Takahashi F, Takahashi K, Saya H, Nagano O.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 3874-3882
- DOI
  10.1111/cas.13826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-18K15215, KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
[Journal Article] Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans2017
- Author(s)
  K Tsuchihashi, H　Kusaba, Y　Yamada, Y　Okumura, H　Kumagai, M　 Komoda, K　Uchino, T Yoshihiro, N　Tsuruta, F　Hanamura, K　 Inadomi, M　Ito, K　Sagara, M　Nakano, K Nio, K　Kohashi, S　Arita, H　Ariyama, R　Tominaga, Y　Oda, K　Akashi, E　Baba
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 印刷中 Issue: 5 Pages: 665-668
- DOI
  10.3892/mco.2017.1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18454, KAKENHI-PROJECT-17K08722, KAKENHI-PROJECT-17K15645
[Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016
- Author(s)
  Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O.
- Journal Title
  
  Cancer Research
  
  Volume: in press Issue: 10 Pages: 2954-2963
- DOI
  10.1158/0008-5472.can-15-2121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-14J06883, KAKENHI-PROJECT-25462277, KAKENHI-PROJECT-16K07125, KAKENHI-PROJECT-16K18454
[Presentation] Esophageal cancer shows spontaneous plasticity between epithelial and mesenchymal status2023
- Author(s)
  Kenji Tsuchihashi, Yuki Hirata, Juntaro Yamasaki, Kentaro Suina, Kenro Tanoue, Toshifumi Yae, Kenta Masuda, Eishi Baba, Koichi Akashi, Yuko Kitagawa, Hideyuki Saya, Osamu Nagano
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07638
[Presentation] Presence and its role of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022
- Author(s)
  Kenji Tsuchihashi, Yuki Hirata, Juntaro Yamasaki, Kentaro Suina, Kenro Tanoue, Toshifumi Yae, Kenta Masuda, Eishi Baba, Koichi Akashi, Yuko Kitagawa, Hideyuki Saya, Osamu Nagano
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07638
[Presentation] 食道癌におけるCD44発現に特徴づけられる上皮間葉転換の自然可塑性モデル2022
- Author(s)
  Kenji Tsuchihashi, Juntaro Yamazaki, Kentaro Suina, Eishi Baba, Koichi Akashi, Hideyuki Saya, Osamu Nagano
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07638
[Presentation] PD-L1 expression is regulated by RNA N6-methyladenosine demethylase FTO in colon cancer cells2021
- Author(s)
  Kenji Tsuchihashi, Nobuhiro Tsuruta, Hirofumi Ohmura, Kyoko Yamaguchi, Mamoru Ito, kenro Tanoue, Taichi Isobe, Hiroshi Ariyama, Hitoshi Kusaba, Koichi Akashi, Eishi Baba
- Organizer
  第80回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07638
[Presentation] Glutaminolytic metabolism on CD44vhigh undifferentiated HNSCC cells enhances xCT dependency2017
- Author(s)
  岡崎章悟、新谷昴、土橋賢司、佐谷秀行、永野修
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18454
[Presentation] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016
- Author(s)
  土橋賢司、永野修、岡崎章悟、大村光代、サンペトラオルテア、吉川桃子、清島亮、大西伸幸、益子高、末松誠、馬場英司、赤司浩一、佐谷秀行
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-09
- Data Source
  KAKENHI-PROJECT-16K18454

1. 馬場英司 (00315475)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 高阪真路 (00627119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 前田高宏 (00791972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OKAZAKI Shogo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. OHMURA Mitsuyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ISHIKAWA Miyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAMPETREAN. Oltea

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. ONISHI Nobuyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. WAKIMOTO Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOSHIKAWA Momoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SEISHIMA Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. IWASAKI Yoshimi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MORIKAWA Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. ABE Shinya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKAO Ayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIMIZU Misato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MASUKO Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. NAGANE Motoo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. AKIYAMA Tetsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SUEMATSU Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. AKASHI Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. SAYA Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. NAGANO Osamu

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. Frank Furnari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 佐野元昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 高橋和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 高橋史行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuchihashi Kenji 土橋 賢司

Research Projects

Research Products

Co-Researchers

Development of a targeted therapy for fusion genes in sarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of epitranscriptome on immune escape in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the role of glutamate in xCT-expressing cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic strategry breaking resistance to oxidative stress in gliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGFR promotes glioma progression by regulating xCT and GluN2B-containing NMDA receptor signaling.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Esophageal cancer shows spontaneous plasticity between epithelial and mesenchymal status2023

Author(s)

Organizer

Data Source

[Presentation] Presence and its role of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022

Author(s)

Organizer

Data Source

[Presentation] 食道癌におけるCD44発現に特徴づけられる上皮間葉転換の自然可塑性モデル2022

Author(s)

Organizer

Data Source

[Presentation] PD-L1 expression is regulated by RNA N6-methyladenosine demethylase FTO in colon cancer cells2021

Author(s)

Organizer

Data Source

[Presentation] Glutaminolytic metabolism on CD44vhigh undifferentiated HNSCC cells enhances xCT dependency2017

Author(s)

Organizer

Data Source

[Presentation] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016

Author(s)

Tsuchihashi Kenji 土橋賢司