Hibiya Shuji 日比谷秀爾

Researcher Number	20801963
Other IDs
Affiliation (Current)	2025: 東京科学大学, 東京科学大学病院, 助教
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2018 – 2022: 東京医科歯科大学, 医学部附属病院, 特任助教 2017: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / 内視鏡的バルーン拡張術 / 小腸狭窄 / 内視鏡的狭窄拡張術 / 小腸内視鏡 / クローン病 / 大腸化 / 機能補完 / 大腸・小腸化 / 形質転換 … More / 小腸大腸形質転換 / 長期炎症 / 腸管上皮幹細胞 / 炎症塑性 / ヒト体外モデル / 炎症発がん / オルガノイド / 潰瘍性大腸炎 / 上皮細胞機能不全 / ヒト大腸オルガノイド / 発がん体外モデル / IBD付随がん Less

クローン病小腸狭窄病変に対する内視鏡治療後予後改善を目指した治療法の開発Principal Investigator
- Principal Investigator
  
  日比谷秀爾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Identification of Fate Determinants in Human Small and Large IntestinePrincipal Investigator
- Principal Investigator
  
  Shuji Hibiya
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
The regulation of the plasticity by long-term inflammation in intestinal stem cellsPrincipal Investigator
- Principal Investigator
  
  Shuji Hibiya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
The establishment of human ex vivo model for the carcinogenesis of IBD associated cancerPrincipal Investigator
- Principal Investigator
  
  Hibiya Shuji
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2019 2018 2017 2016 Other

All Journal Article Presentation Other

[Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease2022
- Author(s)
  Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 22 Issue: 1 Pages: 218-218
- DOI
  10.1186/s12876-022-02300-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
[Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022
- Author(s)
  Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
- Journal Title
  
  Lancet Gastroenterol Hepatol
  
  Volume: 7 Issue: 3 Pages: 230-237
- DOI
  10.1016/s2468-1253(21)00372-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K15991, KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
[Journal Article] Importance of Telomere Shortening in the Pathogenesis of Ulcerative Colitis: A New Treatment From the Aspect of Telomeres in Intestinal Epithelial Cells2021
- Author(s)
  Watanabe Sho、Hibiya Shuji、Katsukura Nobuhiro、Kitagawa Sayuki、Sato Ayako、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 16 Issue: 1 Pages: 109-121
- DOI
  10.1093/ecco-jcc/jjab115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-21K15918
[Journal Article] Serum leucine-rich α-2 glycoprotein; a novel biomarker for small bowel mucosal activity in Crohn’s Disease.2021
- Author(s)
  Kawamoto T, Takenaka K, Hibiya S, Ohtsuka K, Okamoto R, Watanabe M
- Journal Title
  
  Clin Gastroenterol Hepatol.
  
  Volume: 20 Issue: 5 Pages: e1196-e1200
- DOI
  10.1016/j.cgh.2021.06.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15991
[Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.2019
- Author(s)
  Nishimura R, Shirasaki T, Tsuchiya K, Miyake Y, Watanabe Y, Hibiya S, Watanabe S, Nakamura T, Watanabe M
- Journal Title
  
  J Gastroenterol.
  
  Volume: in press Issue: 7 Pages: 608-620
- DOI
  10.1007/s00535-018-01540-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-19K17425
[Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019
- Author(s)
  Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: inpress Issue: 7 Pages: 1545-1552
- DOI
  10.1016/j.cgh.2019.08.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19K17425
[Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer.2019
- Author(s)
  Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  Mol Cancer Res.
  
  Volume: in press Issue: 7 Pages: 1459-1467
- DOI
  10.1158/1541-7786.mcr-18-1195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-19K17425, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-17H04024
[Journal Article] 長期炎症による大腸上皮培養細胞形質変化2018
- Author(s)
  日比谷秀爾、土屋輝一郎、渡辺　守
- Journal Title
  
  INTESTINE
  
  Volume: 22 Pages: 91-94
- Data Source
  KAKENHI-PROJECT-17H06654
[Journal Article] Long-term inflammation transforms intestinal epithelial cells of colonic organoids.2017
- Author(s)
  Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  J Crohns Colitis.
  
  Volume: 61 Pages: 621-630
- DOI
  10.1093/ecco-jcc/jjw186
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
[Journal Article] CDX2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis.2016
- Author(s)
  Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Horita N, Negi M, Itoh E, Akashi T, Eishi Y, Motoya S, Takeuchi Y, Kunisaki R, Fukunaga K, Nakamura S, Yoshimura N, Takazoe M, Iizuka B, Suzuki Y, Nagahori M, Watanabe M
- Journal Title
  
  J Gastoenterol Hepatol.
  
  Volume: 61 Issue: 5 Pages: 1032-1039
- DOI
  10.1111/jgh.13645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-17H06654
[Presentation] クローン病小腸病変に対する小腸内視鏡と腸管超音波の検出能の検討2023
- Author(s)
  日比谷秀爾、村川美也子、岡本隆一
- Organizer
  JDDW 2023
- Data Source
  KAKENHI-PROJECT-23K07432
[Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019
- Author(s)
  Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture.2018
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  13th Congress of ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.2018
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Ryu Nishimura, Kiichiro Tsuchiya, Tomonori Shirasaki, Sho Watanabe, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  13th Congress of ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient.2018
- Author(s)
  Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in Ulcerative Colitis.2018
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  Digestive Disease Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation.2018
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells.2017
- Author(s)
  Sho Watanabe, Kiichiro Tsuchiya, Tomoaki Shirasaki, Shuji Hibiya, Shigeru Oshima, Ryu Nishimura, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe.
- Organizer
  United European Gastroenterology Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[Presentation] Establishment of a colonic organoid with Wnt-independent growth by long-term inflammatory stimulation.2017
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Mamoru Watanabe.
- Organizer
  The 76th annual meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06654
[]
[]

1. 岡本隆一 (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 長堀正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
4. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 齊藤詠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 大塚和朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 竹中健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hibiya Shuji 日比谷 秀爾

Research Projects

Research Products

Co-Researchers

クローン病小腸狭窄病変に対する内視鏡治療後予後改善を目指した治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of Fate Determinants in Human Small and Large IntestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation of the plasticity by long-term inflammation in intestinal stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The establishment of human ex vivo model for the carcinogenesis of IBD associated cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of Telomere Shortening in the Pathogenesis of Ulcerative Colitis: A New Treatment From the Aspect of Telomeres in Intestinal Epithelial Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum leucine-rich α-2 glycoprotein; a novel biomarker for small bowel mucosal activity in Crohn’s Disease.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 長期炎症による大腸上皮培養細胞形質変化2018

Author(s)

Journal Title

Data Source

[Journal Article] Long-term inflammation transforms intestinal epithelial cells of colonic organoids.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CDX2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] クローン病小腸病変に対する小腸内視鏡と腸管超音波の検出能の検討2023

Author(s)

Organizer

Hibiya Shuji 日比谷秀爾