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Hibiya Shuji  日比谷 秀爾

ORCIDConnect your ORCID iD *help
Researcher Number 20801963
Other IDs
Affiliation (Current) 2025: 東京科学大学, 東京科学大学病院, 助教
Affiliation (based on the past Project Information) *help 2023: 東京医科歯科大学, 東京医科歯科大学病院, 助教
2018 – 2022: 東京医科歯科大学, 医学部附属病院, 特任助教
2017: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords
Principal Investigator
炎症性腸疾患 / 内視鏡的バルーン拡張術 / 小腸狭窄 / 内視鏡的狭窄拡張術 / 小腸内視鏡 / クローン病 / 大腸化 / 機能補完 / 大腸・小腸化 / 形質転換 … More / 小腸大腸形質転換 / 長期炎症 / 腸管上皮幹細胞 / 炎症塑性 / ヒト体外モデル / 炎症発がん / オルガノイド / 潰瘍性大腸炎 / 上皮細胞機能不全 / ヒト大腸オルガノイド / 発がん体外モデル / IBD付随がん Less
  • Research Projects

    (4 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (8 People)
  •  クローン病小腸狭窄病変に対する内視鏡治療後予後改善を目指した治療法の開発Principal Investigator

    • Principal Investigator
      日比谷 秀爾
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of Fate Determinants in Human Small and Large IntestinePrincipal Investigator

    • Principal Investigator
      Shuji Hibiya
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  The regulation of the plasticity by long-term inflammation in intestinal stem cellsPrincipal Investigator

    • Principal Investigator
      Shuji Hibiya
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  The establishment of human ex vivo model for the carcinogenesis of IBD associated cancerPrincipal Investigator

    • Principal Investigator
      Hibiya Shuji
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

All 2023 2022 2021 2019 2018 2017 2016 Other

All Journal Article Presentation Other

  • [Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease2022

    • Author(s)
      Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe
    • Journal Title

      BMC Gastroenterol.

      Volume: 22 Issue: 1 Pages: 218-218

    • DOI

      10.1186/s12876-022-02300-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
  • [Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022

    • Author(s)
      Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Lancet Gastroenterol Hepatol

      Volume: 7 Issue: 3 Pages: 230-237

    • DOI

      10.1016/s2468-1253(21)00372-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K15991, KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
  • [Journal Article] Serum leucine-rich α-2 glycoprotein; a novel biomarker for small bowel mucosal activity in Crohn’s Disease.2021

    • Author(s)
      Kawamoto T, Takenaka K, Hibiya S, Ohtsuka K, Okamoto R, Watanabe M
    • Journal Title

      Clin Gastroenterol Hepatol.

      Volume: 20 Issue: 5 Pages: e1196-e1200

    • DOI

      10.1016/j.cgh.2021.06.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15991
  • [Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.2019

    • Author(s)
      Nishimura R, Shirasaki T, Tsuchiya K, Miyake Y, Watanabe Y, Hibiya S, Watanabe S, Nakamura T, Watanabe M
    • Journal Title

      J Gastroenterol.

      Volume: in press Issue: 7 Pages: 608-620

    • DOI

      10.1007/s00535-018-01540-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-19K17425
  • [Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019

    • Author(s)
      Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: inpress Issue: 7 Pages: 1545-1552

    • DOI

      10.1016/j.cgh.2019.08.024

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19K17425
  • [Journal Article] 長期炎症による大腸上皮培養細胞形質変化2018

    • Author(s)
      日比谷秀爾、土屋輝一郎、渡辺 守
    • Journal Title

      INTESTINE

      Volume: 22 Pages: 91-94

    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Journal Article] Long-term inflammation transforms intestinal epithelial cells of colonic organoids.2017

    • Author(s)
      Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
    • Journal Title

      J Crohns Colitis.

      Volume: 61 Pages: 621-630

    • DOI

      10.1093/ecco-jcc/jjw186

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
  • [Journal Article] CDX2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis.2016

    • Author(s)
      Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Horita N, Negi M, Itoh E, Akashi T, Eishi Y, Motoya S, Takeuchi Y, Kunisaki R, Fukunaga K, Nakamura S, Yoshimura N, Takazoe M, Iizuka B, Suzuki Y, Nagahori M, Watanabe M
    • Journal Title

      J Gastoenterol Hepatol.

      Volume: 61 Issue: 5 Pages: 1032-1039

    • DOI

      10.1111/jgh.13645

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-17H06654
  • [Presentation] クローン病小腸病変に対する小腸内視鏡と腸管超音波の検出能の検討2023

    • Author(s)
      日比谷秀爾、村川美也子、岡本隆一
    • Organizer
      JDDW 2023
    • Data Source
      KAKENHI-PROJECT-23K07432
  • [Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019

    • Author(s)
      Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
    • Organizer
      ECCO2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture.2018

    • Author(s)
      Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
    • Organizer
      13th Congress of ECCO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.2018

    • Author(s)
      Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
    • Organizer
      DDW 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018

    • Author(s)
      Ryu Nishimura, Kiichiro Tsuchiya, Tomonori Shirasaki, Sho Watanabe, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
    • Organizer
      13th Congress of ECCO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient.2018

    • Author(s)
      Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
    • Organizer
      UEGW 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in Ulcerative Colitis.2018

    • Author(s)
      Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe
    • Organizer
      Digestive Disease Week 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation.2018

    • Author(s)
      Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M
    • Organizer
      UEGW 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells.2017

    • Author(s)
      Sho Watanabe, Kiichiro Tsuchiya, Tomoaki Shirasaki, Shuji Hibiya, Shigeru Oshima, Ryu Nishimura, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe.
    • Organizer
      United European Gastroenterology Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
  • [Presentation] Establishment of a colonic organoid with Wnt-independent growth by long-term inflammatory stimulation.2017

    • Author(s)
      Shuji Hibiya, Kiichiro Tsuchiya, Mamoru Watanabe.
    • Organizer
      The 76th annual meeting of the Japanese Cancer Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06654
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  • 1.  岡本 隆一 (50451935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  長堀 正和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  渡辺 守
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 4.  中村 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  土屋 輝一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 6.  齊藤 詠子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  大塚 和朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  竹中 健人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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