Ohata Yasuhisa 大幡泰久

Researcher Number	20805460
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 助教 2018 – 2021: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 骨形成不全症 / 骨リモデリング / 骨カップリング / 骨芽細胞 / 破骨細胞 Except Principal Investigator くる病 / 骨疾患 / 代謝性骨疾患 / 骨形成 / 骨芽細胞 … More / FGF23 / リン代謝 / 骨折 / 遺伝子発現 / 骨系統疾患 / 低リン血症性くる病 / 骨形成不全症 / 骨細胞 Less

骨形成不全症特異的破骨細胞機能亢進を標的とした新規治療法の開発Principal Investigator
- Principal Investigator
  
  大幡泰久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Analysis of dysfunction of osteocytes to reveal the targets of treatment in genetical bone diseases
- Principal Investigator
  
  Ozono Keiichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Development of new therapy for osteogenesis imperfecta targeting bone couplingPrincipal Investigator
- Principal Investigator
  
  Ohata Yasuhisa
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Association of trabecular bone score and bone mineral apparent density with the severity of bone fragility in children and adolescents with osteogenesis imperfecta: A cross-sectional study2023
- Author(s)
  Ohata Yasuhisa、Kitaoka Taichi、Ishimi Takeshi、Yamada Chieko、Nakano Yukako、Yamamoto Kenichi、Takeyari Shinji、Nakayama Hirofumi、Fujiwara Makoto、Kubota Takuo、Ozono Keiichi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 8 Pages: e0290812-e0290812
- DOI
  10.1371/journal.pone.0290812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15940, KAKENHI-PROJECT-21H02881
[Journal Article] A novel <i>COL1A1</i> deletion/insertion pathogenic variant in a patient with osteogenesis imperfecta2022
- Author(s)
  Yamada Chieko、Kubota Takuo、Ishimi Takeshi、Takeyari Shinji、Yamamoto Kenichi、Nakayama Hirofumi、Ohata Yasuhisa、Fujiwara Makoto、Kitaoka Taichi、Ozono Keiichi
- Journal Title
  
  Clinical Pediatric Endocrinology
  
  Volume: 31 Issue: 3 Pages: 205-208
- DOI
  10.1297/cpe.2022-0027
- ISSN
  0918-5739, 1347-7358
- Language
  English
- Data Source
  KAKENHI-PROJECT-22K15940, KAKENHI-PROJECT-18K15708
[Journal Article] Phosphate promotes osteogenic differentiation through non-canonical Wnt signaling pathway in human mesenchymal stem cells2022
- Author(s)
  Rui Shumin、Kubota Takuo、Ohata Yasuhisa、Yamamoto Kenichi、Fujiwara Makoto、Takeyari Shinji、Ozono Keiichi
- Journal Title
  
  Bone
  
  Volume: 164 Pages: 116525-116525
- DOI
  10.1016/j.bone.2022.116525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02881, KAKENHI-PROJECT-20K08256
[Journal Article] A case of HDR syndrome coexisting with tetralogy of Fallot, with a novel GATA3 mutation, which manifested as a renal abscess2021
- Author(s)
  Ikeuchi Mayo、Kiyota Kyoko、Itonaga Tomoyo、Kawano-Matsuda Fumika、Ohata Yasuhisa、Fujiwara Makoto、Kubota Takuo、Ozono Keiichi、Ihara Kenji
- Journal Title
  
  CEN Case Reports
  
  Volume: 10 Issue: 2 Pages: 241-243
- DOI
  10.1007/s13730-020-00551-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15708
[Journal Article] Neonatal cholestasis can be the first symptom of McCune-Albright syndrome: A case report2021
- Author(s)
  Satomura Yoshinori、Bessho Kazuhiko、Kitaoka Taichi、Takeyari Shinji、Ohata Yasuhisa、Kubota Takuo、Ozono Keiichi
- Journal Title
  
  World Journal of Clinical Pediatrics
  
  Volume: 10 Issue: 2 Pages: 7-14
- DOI
  10.5409/wjcp.v10.i2.7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K15708
[Journal Article] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling2021
- Author(s)
  Ishihara Y, Ohata Y, Takeyari S, Kitaoka T, Fujiwara M, Nakano Y, Yamamoto K, Yamada C, Yamamoto K, Michigami T, Mabe H, Yamaguchi T, Matsui K, Tamada I, Namba N, Yamamoto A, Etoh J, Kawaguchi A, Kosugi R, Ozono K, Kubota T
- Journal Title
  
  Bone
  
  Volume: 153 Pages: 116135-116135
- DOI
  10.1016/j.bone.2021.116135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-21K07797, KAKENHI-PROJECT-18K15708
[Journal Article] Alkaline phosphatase in pediatric patients with genu varum caused by vitamin D-deficient rickets2021
- Author(s)
  Mukai Masashi、Yamamoto Takehisa、Takeyari Shinji、Ohata Yasuhisa、Kitaoka Taichi、Kubota Takuo、Yamamoto Katsusuke、Kijima Eri、Hasegawa Yasuhiro、Michigami Toshimi、Ozono Keiichi
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 7 Pages: 807-815
- DOI
  10.1507/endocrj.EJ20-0622
- NAID
  130008068265
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K15708
[Journal Article] 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts2021
- Author(s)
  Takeyari Shinji、Kubota Takuo、Ohata Yasuhisa、Fujiwara Makoto、Kitaoka Taichi、Taga Yuki、Mizuno Kazunori、Ozono Keiichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100027-100027
- DOI
  10.1074/jbc.ra120.014709
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08256, KAKENHI-PROJECT-18K15708, KAKENHI-PROJECT-18H02780, KAKENHI-PROJECT-21H02881
[Journal Article] Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease2020
- Author(s)
  Nagata Yuki、Miyagawa Kazuaki、Ohata Yasuhisa、Petrusca Daniela N.、Pagnotti Gabriel M.、Mohammad Khalid S.、Guise Theresa A.、Windle Jolene J.、David Roodman G.、Kurihara Noriyoshi
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 122 Issue: 3-4 Pages: 335-348
- DOI
  10.1002/jcb.29861
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23024, KAKENHI-PROJECT-18K15708
[Journal Article] Clinical Practice Guidelines for Hypophosphatasia*2020
- Author(s)
  Michigami Toshimi、Ohata Yasuhisa、Fujiwara Makoto、Mochizuki Hiroshi、Adachi Masanori、Kitaoka Taichi、Kubota Takuo、Sawai Hideaki、Namba Noriyuki、Hasegawa Kosei、Fujiwara Ikuma、Ozono Keiichi
- Journal Title
  
  Clinical Pediatric Endocrinology
  
  Volume: 29 Issue: 1 Pages: 9-24
- DOI
  10.1297/cpe.29.9
- NAID
  130007783622
- ISSN
  0918-5739, 1347-7358
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10076, KAKENHI-PROJECT-18K15708
[Journal Article] Clinical Practice Guidelines for Achondroplasia*2020
- Author(s)
  Kubota Takuo、Adachi Masanori、Kitaoka Taichi、Hasegawa Kosei、Ohata Yasuhisa、Fujiwara Makoto、Michigami Toshimi、Mochizuki Hiroshi、Ozono Keiichi
- Journal Title
  
  Clinical Pediatric Endocrinology
  
  Volume: 29 Issue: 1 Pages: 25-42
- DOI
  10.1297/cpe.29.25
- NAID
  130007783623
- ISSN
  0918-5739, 1347-7358
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15708
[Journal Article] Potential pathological role of single nucleotide polymorphism (c.787T>C) in <i>alkaline phosphatase (ALPL)</i> for the phenotypes of hypophosphatasia2020
- Author(s)
  Matsuda Nozomi、Takasawa Kei、Ohata Yasuhisa、Takishima Shigeru、Kubota Takuo、Ishihara Yasuki、Fujiwara Makoto、Ogawa Erika、Morio Tomohiro、Kashimada Kenichi、Ozono Keiichi
- Journal Title
  
  Endocr J
  
  Volume: 67 Issue: 12 Pages: 1227-1232
- DOI
  10.1507/endocrj.EJ20-0203
- NAID
  130007962226
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15708
[Journal Article] Complete oculocerebrorenal phenotype of Lowe syndrome in a female patient with half reduction of inositol polyphosphate 5-phosphatase2020
- Author(s)
  Yamamoto Katsusuke、Hasegawa Yasuhiro、Ohata Yasuhisa、Satomura Kenichi、Mizoguchi Yoshimi、Shimotsuji Tsunesuke、Yamamoto Takehisa
- Journal Title
  
  CEN Case Reports
  
  Volume: 9 Issue: 2 Pages: 95-100
- DOI
  10.1007/s13730-019-00434-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15708
[Journal Article] Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo2020
- Author(s)
  Miyagawa Kazuaki、Ohata Yasuhisa、Delgado-Calle Jesus、Teramachi Jumpei、Zhou Hua、Dempster David D.、Subler Mark A.、Windle Jolene J.、Chirgwin John M.、Roodman G. David、Kurihara Noriyoshi
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 6
- DOI
  10.1172/jci.insight.133113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-18K15708, KAKENHI-PROJECT-17KK0169
[Journal Article] Phenotypes of a family with XLH with a novel PHEX mutation2020
- Author(s)
  Yamamoto Akiko、Nakamura Toshiro、Ohata Yasuhisa、Kubota Takuo、Ozono Keiichi
- Journal Title
  
  Human Genome Variation
  
  Volume: 7 Issue: 1 Pages: 8-8
- DOI
  10.1038/s41439-020-0095-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15708
[Journal Article] Effect of Asfotase Alfa on Muscle Weakness in a Japanese Adult Patient of Hypophosphatasia with Low ALP Levels2020
- Author(s)
  Yagi T, Aotani D, Imaeda K, Ozono K, Kataoka H, Tanaka T.
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 6 Pages: 811-815
- DOI
  10.2169/internalmedicine.3298-19
- NAID
  130007808736
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-03-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09031, KAKENHI-PROJECT-17KT0126, KAKENHI-PROJECT-18K15708
[Journal Article] Comprehensive genetic analyses using targeted next-generation sequencing and genotype-phenotype correlations in 53 Japanese patients with osteogenesis imperfecta2019
- Author(s)
  Ohata Y., Takeyari S., Nakano Y., Kitaoka T., Nakayama H., Bizaoui V., Yamamoto K., Miyata K., Yamamoto K., Fujiwara M., Kubota T., Michigami T., Yamamoto K., Yamamoto T., Namba N., Ebina K., Yoshikawa H., Ozono K.
- Journal Title
  
  Osteoporosis International
  
  Volume: 30 Issue: 11 Pages: 2333-2342
- DOI
  10.1007/s00198-019-05076-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15708, KAKENHI-PROJECT-17K10076, KAKENHI-PROJECT-18H02780
[Journal Article] Parental somatogonadal COL2A1 mosaicism contributes to intrafamilial recurrence in a family with type 2 collagenopathy2019
- Author(s)
  Yamamoto Kenichi、Kubota Takuo、Takeyari Shinji、Kitaoka Taichi、Miyata Kei、Nakano Yukako、Nakayama Hirofumi、Ohata Yasuhisa、Yanagi Kumiko、Kaname Tadashi、Okada Yukinori、Ozono Keiichi
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 182 Issue: 3 Pages: 454-460
- DOI
  10.1002/ajmg.a.61422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07863, KAKENHI-PROJECT-18K15708
[Journal Article] IGF2 Mutations2019
- Author(s)
  Masunaga Yohei、Inoue Takanobu、Yamoto Kaori、Fujisawa Yasuko、Sato Yasuhiro、Kawashima-Sonoyama Yuki、Morisada Naoya、Iijima Kazumoto、Ohata Yasuhisa、Namba Noriyuki、Suzumura Hiroshi、Kuribayashi Ryota、Yamaguchi Yu、Yoshihashi Hiroshi、Fukami Maki、Saitsu Hirotomo、Kagami Masayo、Ogata Tsutomu
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 105 Issue: 1 Pages: 116-125
- DOI
  10.1210/clinem/dgz034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08243, KAKENHI-PLANNED-17H06428, KAKENHI-PROJECT-17H04204, KAKENHI-PROJECT-17K10078, KAKENHI-PROJECT-18K15708
[Presentation] Clinical Features of FGF23-Related Hypophosphatemic Rickets/Osteomalacia: A Multicenter National Survey in Japan2023
- Author(s)
  Makoto Fujiwara, Taichi Kitaoka, Yasuhisa Ohata, Hirofumi Nakayama, Yukako Nakano, Kenichi Yamamoto, Hiroyuki Saito, Chieko Yamada, Takeshi Ishimi, Ikumi Ueda, Tatsuya Nakamichi, Rieko Takatani, Masanori Minagawa, Inoue Daisuke, Yasuhiro Takeuchi, Seiji Fukumoto, Takashi Akamizu, Keiichi Ozono, and Takuo Kubota
- Organizer
  ASBMR 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 当科XLH患者に対するブロスマブ治療長期効果の検討2023
- Author(s)
  大幡泰久, 山田知絵子, 中野由佳子, 山本賢一, 武鑓真司, 藤原誠, 北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 本邦における FGF23 関連低リン血症性くる病・骨軟化症患者の臨床像の解析2023
- Author(s)
  藤原誠, 石見壮史, 山田知絵子, 武鑓真司, 山本賢一, 中野由佳子, 中山尋文, 大幡泰久, 北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第41回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 海綿骨スコア(TBS)と骨塩見かけ密度(BMAD)は小児骨形成不全症の骨評価に有用2022
- Author(s)
  大幡泰久 , 北岡太一 , 石見壮史 , 山田知絵子 , 中野由佳子 , 武鑓真司 , 山本賢一 , 中山尋文 , 藤原誠 , 窪田拓生 , 大薗恵一
- Organizer
  第32回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-22K15940
[Presentation] 骨形成不全症の新規モデルマウス2022
- Author(s)
  武鑓真司, 大幡泰久, 藤原誠, 北岡太一, 窪田拓生, 大薗恵一
- Organizer
  第55回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] Trabecular Bone Score and Bone Mineral Apparent Density Predict the Severity of Bone Fragility in Children and Adolescents with Osteogenesis Imperfecta. A Cross-sectional Study2022
- Author(s)
  Y. Ohata, T. Kitaoka, T. Ishimi, C. Yamada, Y. Nakano, K. Yamamoto, S. Takeyari, H. Nakayama, M. Fujiwara, T. Kubota, K. Ozono
- Organizer
  American Society for Bone and Mineral Research Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Year Book 骨代謝・副甲状腺・骨系統疾患2022
- Author(s)
  大幡泰久
- Organizer
  第55回日本小児内分泌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] 小児骨形成不全症におけるビスホスホネート治療および体重は血清スクレロスチン値に影響する2022
- Author(s)
  藤原誠, 北岡太一, 石見壮史, 山田知絵子, 武鑓真司, 山本賢一, 中野由佳子, 中山尋文, 大幡泰久, 窪田拓生, 大薗恵一
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] Col1a1G643S/+ mouse model of osteogenesis imperfecta2022
- Author(s)
  Shinji Takeyari, Yasuhisa Ohata, Makoto Fujiwara, Taichi Kitaoka, Takuo Kubota, Keiichi Ozono
- Organizer
  ASBMR 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] Year Book 骨代謝・副甲状腺・骨系統疾患2022
- Author(s)
  大幡泰久
- Organizer
  第55回日本小児内分泌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15940
[Presentation] Trabecular Bone Score and Bone Mineral Apparent Density Predict the Severity of Bone Fragility in Children and Adolescents with Osteogenesis Imperfecta. A Cross-sectional Study2022
- Author(s)
  Y. Ohata, T. Kitaoka, T. Ishimi, C. Yamada, Y. Nakano, K. Yamamoto, S. Takeyari, H. Nakayama, M. Fujiwara, T. Kubota, K. Ozono
- Organizer
  American Society for Bone and Mineral Research Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15940
[Presentation] 海綿骨スコア(TBS)と骨塩見かけ密度(BMAD)は小児骨形成不全症の骨評価に有用2022
- Author(s)
  大幡泰久 , 北岡太一 , 石見壮史 , 山田知絵子 , 中野由佳子 , 武鑓真司 , 山本賢一 , 中山尋文 , 藤原誠 , 窪田拓生 , 大薗恵一
- Organizer
  第32回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Genotype-phenotype analysis and the importance of the zinc binding site of PHEX using 3D structure modeling in Japanese patients with X-linked hypophosphatemic rickets2021
- Author(s)
  Y. Ohata, Y. Ishihara, S. Takeyari, T. Kitaoka, M. Fujiwara, Y. Nakano, K. Yamamoto, C. Yamada, K. Yamamoto, T. Michigami, H. Mabe, T. Yamaguchi, K. Matsui, I. Tamada, N. Namba, A. Yamamoto, J. Etoh, A. Kawaguchi, R. Kosugi, K. Ozono, and T. Kubota
- Organizer
  American society for bone mineral research annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling.2021
- Author(s)
  Ohata Y, Ishihara Y, Takeyari S, Kubota T, Ozono K
- Organizer
  American Society for Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02881
[Presentation] 長期管理中のStAR異常による46,XX先天性リポイド副腎過形成症の一例2021
- Author(s)
  大幡泰久、山本賢一、中野由佳子、石見壮史、武鑓真司、山田知絵子、藤原誠、北岡太一、三善陽子、窪田拓生、大薗恵一
- Organizer
  日本ステロイドホルモン学会
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Year Book 1 骨代謝2021
- Author(s)
  大幡泰久
- Organizer
  日本小児内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling2021
- Author(s)
  大幡泰久、石原康貴、武鑓真司、北岡太一、藤原誠、中野由佳子、山本賢一、山田知絵子、山本勝輔、道上敏美、間部裕代、山口健史、松井克之、玉田泉、難波範行、山本晶子、江藤潤也、河口亜津彩、小杉理英子、窪田拓生、大薗恵一
- Organizer
  日本小児内分泌学会
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] 副甲状腺機能低下症の診断と治療2021
- Author(s)
  大幡泰久
- Organizer
  臨床内分泌Update
- Invited
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Pathogenic Variants of GNAS Gene Generating Abnormal Amino Acid Sequences in the β6 Strand / α5 Helix of Gsα in 2 Unrelated Japanese Patients with Pseudohypoparathyroidism 1A / Pseudopseudohypoparathyroidism2020
- Author(s)
  Yasuhisa Ohata, Haruna Kakimoto, Yasuki Ishihara, Makoto Fujiwara, Shinji Takeyari, Taichi Kitaoka, Hirofumi Nakayama, Yukako Nakano, Kenichi Yamamoto, Chieko Yamada, Takeshi Ishimi, Takuo Kubota, Keiichi Ozono
- Organizer
  American society for bone mineral research annual meeting
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Gsαタンパクのβ6 strand /α5 helix部位に異常なアミノ酸配列が付加されるGNAS遺伝子新規変異は偽性副甲状腺機能低下症/偽性偽性副甲状腺機能低下症の原因となりうる-非血縁2家系症例の検討2020
- Author(s)
  大幡泰久、藤原誠、石原康貴、窪田拓生、北岡太一、中山尋文、武鑓真司、山本賢一、中野由佳子、大薗恵一
- Organizer
  日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] 日本人XLH患者38名のPHEX遺伝子解析結果と表現型相関の検討 Mutational analysis of the PHEX gene and genotype-phenotype correlation in 38 Japanese patients with X-linked hypophosphatemic rickets2019
- Author(s)
  大幡泰久, 石原康貴, 窪田拓生, 武鑓真司, 北岡太一, 中山尋文, 中野由佳子, 山本賢一, 宮田京, 山田知絵子, 藤原誠, 山本勝輔, 道上敏美, 難波範行, 間部裕代, 山口健史, 松井克之, 玉田泉, 山本晶子, 江藤潤也, 河口亜津彩, 大薗恵一
- Organizer
  日本小児内分泌学会
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Mutational analysis of the PHEX gene and genotype-phenotype correlation in 37 Japanese patients with X-linked hypophosphatemic rickets2019
- Author(s)
  Yasuhisa Ohata, Takuo Kubota, Shinji Takeyari, Taichi Kitaoka, Yasuki Ishihara, Hirofumi Nakayama, Yukako Nakano, Kenichi Yamamoto, Kei Miyata, Chieko Yamada, Makoto Fujiwara, Katsusuke Yamamoto, Toshimi Michigami, Hiroyo Mabe, Takeshi Yamaguchi, Katsuyuki Matsui, Izumi Tamada, Noriyuki Namba,Keiichi Ozono et al.
- Organizer
  American society for bone mineral research annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] 日本人XLH患者37名のPHEX遺伝子解析結果と表現型相関の検討 Mutational analysis of the PHEX gene and genotype-phenotype correlation in 37 Japanese patients with X-linked hypophosphatemic rickets2019
- Author(s)
  大幡泰久, 石原康貴, 窪田拓生, 武鑓真司, 北岡太一, 中山尋文, 中野由佳子, 山本賢一, 藤原誠, 道上敏美,　難波範行, 大薗恵一
- Organizer
  日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] ターゲットエクソーム解析を用いた日本人骨形成不全患者55名の網羅的遺伝子解析と表現型解析2018
- Author(s)
  大幡泰久、武鑓真司、中野由佳子、山本賢一、宮田京、中山尋文、Varoona Bizaoui、北岡太一、窪田拓生、山本勝輔、道上敏美、山本威久、大薗恵一
- Organizer
  日本小児内分泌学会
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Comprehensive Genetic Analysis by Targeted Next Generation Sequencing and Genotype-Phenotype Correlation of 55 Japanese Patients with Osteogenesis Imperfecta2018
- Author(s)
  Yasuhisa Ohata, Shinji Takeyari, Taichi Kitaoka, Hirofumi Nakayama, Varoona Bizaoui, Yukako Nakano, Kenichi Yamamoto, Kei Miyata, Keiko Yamamoto, Takuo Kubota, Katsusuke Yamamoto, Toshimi Michigami, Takehisa Yamamoto,and Keiichi Ozono
- Organizer
  American society for bone mineral research annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15708
[Presentation] Comprehensive genetic analysis by targeted next generation sequencing and genotype-phenotype correlation of 53 Japanese patients with osteogenesis imperfecta2018
- Author(s)
  Yasuhisa Ohata, Shinji Takeyari, Yukako Nakano, Kenichi Yamamoto, Hirofumi Nakayama, Taichi Kitaoka, Takuo Kubota, Toshimi Michigami, Takehisa Yamamoto, and Keiichi Ozono
- Organizer
  日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K15708

1. Ozono Keiichi (20270770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 道上敏美 (00301804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 窪田拓生 (40629135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. 岡田随象 (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TERAMACHI Jyumpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. MORISADA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 宮川和晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 要匡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohata Yasuhisa 大幡 泰久

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骨形成不全症特異的破骨細胞機能亢進を標的とした新規治療法の開発Principal Investigator

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Analysis of dysfunction of osteocytes to reveal the targets of treatment in genetical bone diseases

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Development of new therapy for osteogenesis imperfecta targeting bone couplingPrincipal Investigator

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[Journal Article] Association of trabecular bone score and bone mineral apparent density with the severity of bone fragility in children and adolescents with osteogenesis imperfecta: A cross-sectional study2023

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[Journal Article] A novel <i>COL1A1</i> deletion/insertion pathogenic variant in a patient with osteogenesis imperfecta2022

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[Journal Article] Phosphate promotes osteogenic differentiation through non-canonical Wnt signaling pathway in human mesenchymal stem cells2022

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[Journal Article] A case of HDR syndrome coexisting with tetralogy of Fallot, with a novel GATA3 mutation, which manifested as a renal abscess2021

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[Journal Article] Neonatal cholestasis can be the first symptom of McCune-Albright syndrome: A case report2021

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[Journal Article] Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling2021

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[Journal Article] Alkaline phosphatase in pediatric patients with genu varum caused by vitamin D-deficient rickets2021

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[Journal Article] 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts2021

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[Journal Article] Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease2020

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[Journal Article] Clinical Practice Guidelines for Hypophosphatasia*2020

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Ohata Yasuhisa 大幡泰久

[Journal Article] Potential pathological role of single nucleotide polymorphism (c.787T>C) in <i>alkaline phosphatase (ALPL)</i> for the phenotypes of hypophosphatasia2020