tanaka masatake 田中正剛

… Alternative Names

Tanana Masatake 田中正剛

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Researcher Number	20837265
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 九州大学, 大学病院, 助教 2019 – 2020: 九州大学, 生体防御医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator NASH / 非アルコール性脂肪肝炎 / 閉経後 / 一細胞遺伝子発現解析 / 肝星細胞 / マクロファージ / クッパー細胞 / エストロゲン / 閉経 / hypoxia inducible factor … More / 低酸素 / T細胞 / zone 3 / 類洞内皮細胞 / IL-17 / レーザーマイクロダイセクション / RNA-seq / 網羅的遺伝子発現解析 / zonation … More Except Principal Investigator 肝硬変 / 線維化 / 右心不全 Less

一細胞遺伝子発現解析を用いたMASHにおける自然免疫と獲得免疫のクロストークの解明Principal Investigator
- Principal Investigator
  
  田中正剛
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyushu University
Elucidating the Mechanisms and Reversibility of Congestive Hepatic Fibrosis in Right Heart Failure Using Multimodality Approaches
- Principal Investigator
  
  山村健一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyushu University
The study about the mechanism of postmenopausal non-alcoholic steatohepatitis using single-cell RNA sequencingPrincipal Investigator
- Principal Investigator
  
  田中正剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyushu University
Elucidation of the mechanism of non-alcoholic steatohepatitis focusing on the metabolic zonation in the liver.Principal Investigator
- Principal Investigator
  
  Tanana Masatake
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation2022
- Author(s)
  Tashiro Shigeki、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Kurokawa Miho、Imoto Koji、Kuwano Akifumi、Takahashi Motoi、Suzuki Hideo、Kohjima Motoyuki、Kato Masaki、Ogawa Yoshihiro
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 434 Pages: 115817-115817
- DOI
  10.1016/j.taap.2021.115817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PROJECT-20K22877, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04949, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-21K15976
[Journal Article] Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency2022
- Author(s)
  Imoto Koji、Tanaka Masatake、Goya Takeshi、Aoyagi Tomomi、Takahashi Motoi、Kurokawa Miho、Tashiro Shigeki、Kato Masaki、Kohjima Motoyuki、Ogawa Yoshihiro
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 22 Issue: 1 Pages: 144-144
- DOI
  10.1186/s12876-022-02213-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04949
[Journal Article] Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway.2021
- Author(s)
  5.Yoshizaki S, Tamaru T, Hara M, Kijima K, Tanaka M, Konno D, Matsumoto Y, Nakashima Y, Okada S.
- Journal Title
  
  J Neuroinflammation
  
  Volume: 18 Issue: 1
- DOI
  10.1186/s12974-020-02059-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03771, KAKENHI-PROJECT-19K17496
[Journal Article] Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma2021
- Author(s)
  Suzuki Hideo、Kohjima Motoyuki、Tanaka Masatake、Goya Takeshi、Itoh Shinji、Yoshizumi Tomoharu、Mori Masaki、Tsuda Mariko、Takahashi Motoi、Kurokawa Miho、Imoto Koji、Tashiro Shigeki、Kuwano Akifumi、Kato Masaki、Okada Seiji、Nakamuta Makoto、Ogawa Yoshihiro
- Journal Title
  
  Canadian Journal of Gastroenterology and Hepatology
  
  Volume: 2021 Pages: 1-13
- DOI
  10.1155/2021/8813410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PUBLICLY-20H04949, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-19H03771
[Journal Article] Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified2021
- Author(s)
  Okuno Hiroaki、Ogino Haruei、Ihara Eikichi、Nishioka Kei、Tanaka Yoshimasa、Chinen Takatoshi、Kohjima Motoyuki、Oono Takamasa、Tanaka Masatake、Goya Takeshi、Fujimori Nao、Iboshi Yoichiro、Gotoda Takuji、Ogawa Yoshihiro
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1 Pages: 73-73
- DOI
  10.1186/s12876-021-01656-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PROJECT-20K08389, KAKENHI-PROJECT-16K21751
[Journal Article] Association of lenvatinib plasma concentration with clinical efficacy and adverse events in patients with hepatocellular carcinoma2020
- Author(s)
  Hata Kojiro、Suetsugu Kimitaka、Egashira Nobuaki、Makihara Yoko、Itoh Shinji、Yoshizumi Tomoharu、Tanaka Masatake、Kohjima Motoyuki、Watanabe Hiroyuki、Masuda Satohiro、Ieiri Ichiro
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 86 Issue: 6 Pages: 803-813
- DOI
  10.1007/s00280-020-04178-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PROJECT-20K16078, KAKENHI-PROJECT-18H02588
[Journal Article] 肝内リンパ管新生とその機序2020
- Author(s)
  田中　正剛、岩切　泰子
- Journal Title
  
  日本門脈圧亢進症学会雑誌
  
  Volume: 26 Pages: 5-8
- NAID
  40022226546
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17496
[Journal Article] Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients2019
- Author(s)
  Imoto Koji、Kohjima Motoyuki、Hioki Tomonobu、Kurashige Tomoyuki、Kurokawa Miho、Tashiro Shigeki、Suzuki Hideo、Kuwano Akifumi、Tanaka Masatake、Okada Seiji、Kato Masaki、Ogawa Yoshihiro
- Journal Title
  
  Canadian Journal of Gastroenterology and Hepatology
  
  Volume: 2019 Pages: 1-12
- DOI
  10.1155/2019/6391712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PUBLICLY-18H05039, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-19H03771, KAKENHI-PROJECT-17K09430
[Journal Article] The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury2019
- Author(s)
  Yoshizaki Shingo、Yokota Kazuya、Kubota Kensuke、Saito Takeyuki、Tanaka Masatake、Konno Dai-jiro、Maeda Takeshi、Matsumoto Yoshihiro、Nakashima Yasuharu、Okada Seiji
- Journal Title
  
  Spinal Cord
  
  Volume: - Issue: 5 Pages: 537-543
- DOI
  10.1038/s41393-019-0395-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PROJECT-19H03771
[Journal Article] Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury2019
- Author(s)
  Yoshizaki Shingo、Kijima Ken、Hara Masamitsu、Saito Takeyuki、Tamaru Tetsuya、Tanaka Masatake、Konno Dai-jiro、Nakashima Yasuharu、Okada Seiji
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 16 Issue: 1
- DOI
  10.1186/s12974-019-1536-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17496, KAKENHI-PROJECT-19H03771
[Presentation] NASHモデルマウスにおける肝線維化機序の解明2023
- Author(s)
  井本効志, 東夕喜, 大野あかり, 青柳知美, 高橋基, 黒川美穂, 合谷孟, 田中正剛, 国府島庸之, 小川佳宏
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07963
[Presentation] 肝非実質細胞を介した閉経後NASHの発症増悪メカニズムの解析2023
- Author(s)
  合谷孟, 青柳知美, 鈴木秀生, 東夕喜, 日置智惟, 高橋基, 井本効志, 黒川美穂, 田代茂樹, 田中正剛, 国府島庸之, 小川佳宏
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07963
[Presentation] 肝非実質細胞に注目した閉経後NASHの発症・増悪メカニズムの解析2022
- Author(s)
  青柳知美、鈴木秀生、高橋基、井本効志、東夕喜、大野あかり、黒川美穂、田代茂樹、合谷孟、田中正剛、国府島庸之、小川佳宏
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07963
[Presentation] NASH関連肝癌モデルマウスを用いた抗PD-1抗体の肝癌に対する効果についての検討2022
- Author(s)
  高橋基、国府島庸之、東夕喜、大野あかり、青柳知美、井本効志、黒川美穂、田代茂樹、合谷孟、田中正剛、小川佳宏
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K07963
[Presentation] 非アルコール性脂肪肝疾患の組織学的特徴に関連した臨床病態及び遺伝子発現変化の検討2021
- Author(s)
  井本効志、田代茂樹、日置智惟、川元美緒、高橋基、黒川美穂、鈴木秀生、合谷孟、田中正剛、加藤正樹、国府島庸之、小川佳宏
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 肝細胞癌における糖・脂質代謝関連遺伝子発現の変化：高分化型肝細胞癌における脂肪蓄積のメカニズム2021
- Author(s)
  鈴木秀生、高橋基、井本効志、黒川美穂、田代茂樹、合谷孟、田中正剛、加藤正樹、伊藤心二、吉住朋晴、森正樹、中牟田誠、国府島庸之、小川佳宏
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 一細胞遺伝子発現解析を用いたNASH病態進展における非実質細胞の量的・質的変化の解明2021
- Author(s)
  国府島庸之、鈴木秀生、田中正剛
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] IFNγは急性肝障害の類洞血流障害に関与する2021
- Author(s)
  黒川美穂、桒野哲史、日置智惟、川元美緒、高橋基、井本効志、田代茂樹、鈴木秀生、合谷孟、田中正剛、加藤正樹、国府島庸之、小川佳宏
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 肝生検で診断した免疫チェックポイント阻害剤による肝障害の臨床的特徴2021
- Author(s)
  日置智惟、川元美緒、高橋基、井本効志、黒川美穂、鈴木秀生、田代茂樹、合谷孟、田中正剛、加藤正樹、国府島庸之、小川佳宏
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 肝細胞癌患者におけるlenvatinib血中濃度と奏効率および有害事象の関連2021
- Author(s)
  高橋基、日置智惟、川元美緒、井本効志、黒川美穂、田代茂樹、鈴木秀生、秦晃二郎、合谷孟、田中正剛、加藤正樹、国府島庸之、小川佳宏
- Organizer
  第57回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 進行肝細胞がんに対する分子標的薬治療における最適な薬剤選択順及び他治療との組み合わせ2020
- Author(s)
  杉本理恵、佐藤丈顕、田中紘介、千住猛士、矢田雅佳、吉本剛志、山下尚毅、荒武良総、國吉政美、田中正剛、上田哲弘、多田靖哉、高尾信一郎、大穂有恒、内村浩太郎、中牟田誠、田中ゆき、大江真里、国府島庸之、加藤正樹
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 免疫チェックポイント阻害剤による肝障害の臨床的特徴2020
- Author(s)
  日置智惟、豊田優貴、倉重智之、井本効志、黒川美穂、鈴木秀生、田代茂樹、桒野哲史、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] MC4R欠損マウスを用いた閉経後女性におけるNASH発症メカニズムの解析2020
- Author(s)
  鈴木秀生、黒川美穂、井本効志、田代茂樹、合谷孟、桒野哲史、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 鉄中毒による急性肝不全に対し集学的治療を行い救命した一例2020
- Author(s)
  黒川美穂、倉重智之、日置智惟、井本効志、田代茂樹、鈴木秀生、桒野哲史、田中正剛、国府島庸之、加藤正樹
- Organizer
  第46回日本急性肝不全研究会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 好中球リンパ球比を用いた非アルコール性脂肪性肝疾患（NAFLD）患者における発癌高リスク群の囲い込み2020
- Author(s)
  井本効志、国府島庸之、日置智惟、倉重智之、黒川美穂、田代茂樹、鈴木秀生、桒野哲史、田中正剛、加藤正樹、小川佳宏
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] Glecaprevir+Pibrentasvir併用療法の糖質・脂質代謝, 体組成分布に対する影響2020
- Author(s)
  田代茂樹、国府島庸之、本村健太、中牟田誠、佐藤丈顕、多田靖哉、杉本理恵、大穂有恒、古藤和浩、徳松誠、横田昌樹、小柳年正、鶴田悟、國吉政実、森園周祐、内村浩太郎、本田正直、田畑伸司、田中正剛、加藤正樹
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] NAFLDにおける組織学的肝内微小構造形成に関わる臨床的特徴と遺伝子発現変化2020
- Author(s)
  田中正剛、国府島庸之、黒川美穂、井本効志、田代茂樹、鈴木秀生、桒野哲史、豊田優貴、日置智惟、倉重智之、加藤正樹、小川佳宏
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 閉経後女性における脂肪肝発症メカニズムの解析とその臨床的特徴の検討2019
- Author(s)
  鈴木英生、倉重智之、正月泰士、井本効志、黒川美穂、田代茂樹、桒野哲史、田中正剛、国府島庸之、加藤正樹、小川佳宏
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] 門脈圧亢進症モデルラットにおける交感神経誘導性リンパ管新生という新規機序の発見2019
- Author(s)
  田中　正剛、国府島　庸之、加藤　正樹、岡田　誠司、小川　佳宏、岩切　泰子
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] NAFLDにおけるSteatosis, Inflammation, Ballooning, Mallory-Denk body, Fibrosisの各因子と関連する臨床的特徴と遺伝子発現変化2019
- Author(s)
  国府島庸之、田代茂樹、鈴木秀生、桒野哲史、倉重智之、井本効志、正月泰士、田中正剛、加藤正樹、小川佳宏
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17496
[Presentation] The Effects of Menopause and Fructose Intake On NAFLD/NASH Development2019
- Author(s)
  Hideo Suzuki, Motoyuki Kohjima, Koji Imoto, Miho Kurokawa, Shigeki Tashiro, Akifumi Kuwano, Masatake Tanaka, Masaki Kato and Yoshihiro Ogawa
- Organizer
  The Liver Meeting (The annual meeting of American Association for Studying Liver Diseases)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17496

1. 合谷孟 (30884754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 山村健一郎 (30532858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩崎健 (40766185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 坂本一郎 (90616616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKADA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

tanaka masatake 田中 正剛

Tanana Masatake 田中 正剛

Research Projects

Research Products

Co-Researchers

一細胞遺伝子発現解析を用いたMASHにおける自然免疫と獲得免疫のクロストークの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the Mechanisms and Reversibility of Congestive Hepatic Fibrosis in Right Heart Failure Using Multimodality Approaches

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study about the mechanism of postmenopausal non-alcoholic steatohepatitis using single-cell RNA sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of non-alcoholic steatohepatitis focusing on the metabolic zonation in the liver.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of lenvatinib plasma concentration with clinical efficacy and adverse events in patients with hepatocellular carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 肝内リンパ管新生とその機序2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] NASHモデルマウスにおける肝線維化機序の解明2023

tanaka masatake 田中正剛

Tanana Masatake 田中正剛