KUBOTA Isao 久保田功

… Alternative Names

久保田功クボタイサオ

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Researcher Number	30161673
Other IDs
External Links
Affiliation (Current)	2023: 山形大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2020: 山形大学, 学内共同利用施設等, 理事 2019: 山形大学, 山形大学, 名誉教授 2017 – 2018: 山形大学, 学内共同利用施設等, 理事 2016: 山形大学, 理事 2009 – 2016: Yamagata University, 医学部, 教授 … More 2004 – 2007: 山形大学, 医学部, 教授 2000: Okitama Public Hospital, Chief, 医長 1995 – 1999: Yamagata Univ.Sch.of Med., Assistant Prof., 医学部, 助教授 1993: 山形大学, 医学部, 講師 1989 – 1991: 山形大学, 医学部, 講師 1989: Yamagata Univ. Sch. of Med. Instructor, 医学部, 助教授 1988: 山形大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Cardiovascular medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Circulatory organs internal medicine / Epidemiology and preventive medicine / Neurosurgery
Keywords	Principal Investigator HMGB1 / 心筋虚血 / アセチル化 / 心不全 / remodeling / doxorubicin / atherosclerosis / oxidative stress / innate immunity / cardiac remodeling … More / myocardial infarction / angiogenesis / myocardial ischemia / myocardial hypoxia / activation-recovery interval / fransient cutward current / cyclic AMP / giant negative T wave / カリウム・チャネル / グリベンクラマイド / HMGB-1 / 心肥大 / 心筋梗塞 / 血管新生 / 慢性心不全 / 胎児型遺伝子 / クロマチン / 糖尿病 / 脂質異常症 / 老化 / 加齢 / 心筋細胞 / DNA障害 / ＳＭＰ３０ / 虚血再灌流 / toll-like receptor / dxorubicin / Toll-like receptor / inflammation / immunity / heart failure / HMBG1 / 核内 HMGB1 / Sirt7 / 脱アセチル化 / 翻訳後修飾 … More Except Principal Investigator 心筋虚血 / 冠動脈硬化 / 急性心筋梗塞 / 心ポンプ機能 / 高脂血症 / 糖尿病 / 心筋梗塞 / 動脈硬化 / PTCA / 血小板 / 内膜肥厚 / atherosclerosis / hypertriglyceridemia / WHHL / 心肥大 / 心拡大 / 心不全 / リモデリング / 内皮細胞 / ATP感受性にチャンネル / 内皮細胞依存性弛緩 / 冠循環 / 加算平均心電図 / 体表面マッピング / 心表面マッピング / 心室頻拍 / 周波数分析 / 心室遅延電位 / 心電図加算 / フ-リエ変換 / 逆フ-リエ変換 / Signal-averaged ECG / Body surface mapping / Epicardial mapping / Myocardial infarction / Ventricular tachycardia / Spectral analysis / 冠動脈狭窄 / 冠動脈攣縮 / 再狭窄 / セロトニン / X線照射 / PTcA / 内皮細胞依存性血管弛緩反応 / 冠血行再建術 / 血管内皮細胞 / ミニ豚 / 冠動脈造影法 / coronary artery stenosis / coronary artery spasm / restenosis / platelet / serotonin / X-ray irradiation / 副血行路 / 血管新生 / 成長因子 / 血管新生因子 / collateral / myocardial ischemia / angiogenesis / growth facter / vascular development / 死亡率 / 再灌流療法 / リポ蛋白 / 高トリグリセライド血症 / ST交互脈 / 心室細動 / ディファレンシャル・デイスプレイ / 急性期死亡 / 冠攣縮 / 不安定狭心症 / 粥腫 / 血清コレステロール / 血清トリプリセライド / リポ蛋白質 / acut myocardiol infarction / mortality / reperfusion therapy / lipoprotein / ST alternans / ventricular fibrillation / 危険因子 / 高コレステロール血症 / 高トリグリセリド血症 / 虚血性心臓病 / 食後高脂血症 / 遺伝形質 / 遺伝要因 / 複合型高脂血症 / 冠動脈疾患 / インスリン抵抗性 / 遺伝様式 / risk factors / hypercholesterolemia / ischemic heart disease / acute myocardial infarction / post-prandial hyperlipidemia / 慢性期心筋梗塞 / 右房ペ-シング / 運動負荷 / ST上昇 / 心表面心電図マッピング / 体表面心電図マッピング / 右房ペーシング / 心筋局所血流 / 心房ペーシング / Chronic myocardial infarction / Right atrial pacing / Exercise test / ST elevation / Epicardial ECG mapping / Body surface ECG mapping / Ventricular depolarization / 院外心停止 / 疫学 / 急性冠症候群 / 院外心肺停止 / 地理情報システム / 予防医学 / 循環器疾患 / 循環器 / 疫学研究 / 病院外心肺停止 / 脳神経疾患 / ゲノム解析 Less

Relationship between deacetylation of nuclear High-Mobility Group Box 1 and Sirt7 activation in failing heartPrincipal Investigator
- Principal Investigator
  
  Kubota Isao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
Characteristics of out-of-hospital cardiac arrest patients due to acute myocardial infarction
- Principal Investigator
  
  Hirayama Atsushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  National Cardiovascular Center Research Institute
  Yamagata University
The role of HMGB1 in regulating mitochondrial dysfunction induced by agingPrincipal Investigator
- Principal Investigator
  
  KUBOTA Isao
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamagata University
Assembly of next-generation genomic cohort to enable research of the correlation with gene-environment factors for cardiovascular disease
- Principal Investigator
  
  KAYAMA Takamasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurosurgery
- Research Institution
  Yamagata University
Development of treatment of heart failure targetting at chronic organ damage and chromatin remodelingPrincipal Investigator
- Principal Investigator
  
  KUBOTA Isao
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
Impact of HMGB1 on left ventricular remodeling after myocardial infarction : Novel therapeutic target for neovascularizationPrincipal Investigator
- Principal Investigator
  
  KUBOTA Isao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
High-mobility group box 1 restores cardiac dysfunction after myocardial infarction in transgenic micePrincipal Investigator
- Principal Investigator
  
  KUBOTA Isao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
Role of Toll-like receptor in cardiovascular remodelingPrincipal Investigator
- Principal Investigator
  
  KUBOTA Isao
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
Determinants of the severity of ischemic heart disease with the burden of multiple risk factors.
- Principal Investigator
  
  TOMOIKE Hitonobu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  First Department of Internal Medicine, Yamagata University School of Medicine
急性虚血・再灌流心に生ずるK^+チャネル活性変動の経時的,3次元的評価Principal Investigator
- Principal Investigator
  
  久保田功
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
Interrelationship between blood constituents and vessel wall during exacerbation and quiescence of myocardial ischemia.
- Principal Investigator
  
  TOMOIKE Hitonobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
虚血心におけるK^+チャネル活性変動に関する実験的研究Principal Investigator
- Principal Investigator
  
  久保田功
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
Role of growth factors in angiogenesis and enlargement of coronary collateral channels.
- Principal Investigator
  
  TOMOIKE Hitonobu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
心・血管の構築変化と心不全の発現を規定する適応臨界点に関する研究
- Principal Investigator
  
  TOMOIKE Hitonobu
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yamagata University
冠血管床と心内膜において産生される血管抵抗調節物質の特性とその遊離機序
- Principal Investigator
  
  友池仁暢
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yamagata University
Experimental and clinical study of the ventricular late-potentialPrincipal Investigator
- Principal Investigator
  
  IKEDA Kozue, 久保田功, TSUIKI Kai
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University
Mechanisms of Restenosis Following Coronary Angioplasty and its Prevention
- Principal Investigator
  
  TOMOIKE Hitonobu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University School of Medicine
  Kyushu University
Experimental and Clinical Study to the Mechanism of Exercise-induced ST Elevation in Chronic Myocardial Infarction
- Principal Investigator
  
  YASUI Shoji
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamagata University School of Medicine

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All Journal Article Presentation Book

[Book] 循環器疾患最新の治療2014
- Author(s)
  渡邉哲,久保田功
- Total Pages
  528
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24659380
[Book] 循環器疾患最新の治療2014
- Author(s)
  渡邉哲，久保田功
- Total Pages
  528
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24659380
[Book] Brugada症候群2012
- Author(s)
  渡邉哲, 久保田功
- Publisher
  循環器疾患最新の治療
- Data Source
  KAKENHI-PROJECT-21590923
[Journal Article] Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response.2019
- Author(s)
  Tetsuya Takahashi, Tetsuro Shishido, Daisuke Kinoshita, Ken Watanabe, Taku Toshima, Takayuki Sugai, Taro Narumi, Yoichiro Otaki, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, Chang-Hoon Woo, Jun-ichi Abe, Yasuchika Takeishi, Isao Kubota and Masafumi Watanabe
- Journal Title
  
  JACC Basic Transl Sci.
  
  Volume: 4 Pages: 234-234
- DOI
  10.1016/j.jacbts.2018.11.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08025, KAKENHI-PROJECT-18K08059
[Journal Article] Ventricular wall stress and silent myocardial damage are associated with pulse pressure in the general population.2018
- Author(s)
  Takahashi T, Shishido T, Watanabe K, Sugai T, Toshima T, Kinoshita D, Yokoyama M, Tamura H, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Shibata Y, Konta T, Ueno Y, Kato T, Kayama T, Kubota I, Watanabe M.
- Journal Title
  
  J Clin Hypertens (Greenwich).
  
  Volume: 33 Pages: 1319-1326
- DOI
  10.1111/jch.13349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08025, KAKENHI-PROJECT-18K08059, KAKENHI-PROJECT-18H03188
[Journal Article] The Neutrophil-to-Lymphocyte Ratio Predicts All-Cause Mortality in Patients with Implantable Cardioverter Defibrillators.2017
- Author(s)
  Hashimoto N, Arimoto T, Narumi T, Iwayama T, Kutsuzawa D, Ishigaki D, Kumagai YU, Tamura H, Nishiyama S, Takahashi H, Shishido T, Miyamoto T, Watanabe T, Kubota I.
- Journal Title
  
  Pacing Clin Electrophysiol.
  
  Volume: 40 Pages: 135-144
- DOI
  10.1111/pace.13003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461122
[Journal Article] The impact of non-alcoholic fatty liver disease fibrosis score on cardiac prognosis in patients with chronic heart failure.2017
- Author(s)
  Takahashi T, Watanabe T, Shishido T, Watanabe K, Sugai T, Toshima T, Kinoshita D, Yokoyama M, Tamura H, Nishiyama S, Arimoto T, Takahashi H, Yamanaka T, Miyamoto T, Kubota I.
- Journal Title
  
  Heart Vessels.
  
  Volume: Dec
- DOI
  10.1007/s00380-017-1113-1
- Data Source
  KAKENHI-PROJECT-26461122
[Journal Article] Combined assessment of myocardial damage and electrical disturbance in chronic heart failure.2017
- Author(s)
  Kadowaki S, Watanabe T, Otaki Y, Narumi T, Honda Y, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
- Journal Title
  
  World Journal of Cardiology．
  
  Volume: 9 Pages: 457-465
- DOI
  10.4330/wjc.v9.i5.457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461122
[Journal Article] Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study.2016
- Author(s)
  Sato H, Konta T, Ichikawa K, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
- Journal Title
  
  Clinical Experimental Nephrology
  
  Volume: 該当なし Pages: 611-617
- DOI
  10.1007/s10157-015-1193-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253072, KAKENHI-PROJECT-15K09240
[Journal Article] High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects.2016
- Author(s)
  Kohno K, Narimatsu H, Shiono Y, Suzuki I, Kato Y, Sho R, Otani K, Ishizawa K, Yamashita H, Kubota I, Ueno Y, Kato T, Fukao A, Kayama T.
- Journal Title
  
  PLoS One.
  
  Volume: 11
- DOI
  10.1371/journal.pone.0165511
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253072
[Journal Article] The Impact of Superoxide Dismutase-1 Genetic Variation on Cardiovascular and All-Cause Mortality in a Prospective Cohort Study: The Yamagata (Takahata) Study.2016
- Author(s)
  Otaki Y, Watanabe T, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Konta T, Shibata Y, Sato H, Kawasaki R, Daimon M, Ueno Y, Kato T, Kayama T, Kubota I.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0164732
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253072, KAKENHI-PROJECT-16K09092
[Journal Article] Reference values of MostGraph measures for middle-aged and elderly Japanese individuals who participated in annual health checkups.2016
- Author(s)
  Abe Y, Shibata Y, Igarashi A, Inoue S, Sato K, Sato M, Nemoto T, Kobayashi M, Nishiwaki M, Kimura T, Tokairin Y, Kayama T, Kubota I.
- Journal Title
  
  Respir Investig.
  
  Volume: 54 Pages: 148-55
- DOI
  10.1016/j.resinv.2015.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253072
[Journal Article] Trends in the incidences of acute myocardial infarction in coastal and inland areas in Japan: The Yamagata AMI Registry.2016
- Author(s)
  Wanezaki M, Watanabe T, Nishiyama S, Hirayama A, Arimoto T, Takahashi H, Shishido T, Miyamoto T, Kawasaki R, Fukao A, Kubota I.
- Journal Title
  
  J Cardiol.
  
  Volume: - Pages: 117-24
- DOI
  10.1016/j.jjcc.2015.08.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293138, KAKENHI-PROJECT-26253072
[Journal Article] Predictors for mortality from respiratory failure in a general population.2016
- Author(s)
  Kobayashi M, Shibata Y, Inoue S, Igarashi A, Sato K, Sato M, Nemoto T, Abe Y, Nunomiya K, Nishiwaki M, Tokairin Y, Kimura T, Daimon M, Makino N, Watanabe T, Konta T, Ueno Y, Kato T, Kayama T, Kubota I.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 26053-26053
- DOI
  10.1038/srep26053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253072, KAKENHI-PROJECT-26461153
[Journal Article] Gene-environment interactions in obesity: implication for future applications in preventive medicine.2016
- Author(s)
  Nakamura S, Narimatsu H, Sato H, Sho R, Otani K, Kawasaki R, Karasawa S, Daimon M, Yamashita H, Kubota I, Ueno Y, Kato T, Yoshioka T, Fukao A, Kayama T.
- Journal Title
  
  J Hum Genet
  
  Volume: 61 Pages: 317-22
- DOI
  10.1038/jhg.2015.148
- NAID
  40020802847
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460737, KAKENHI-PROJECT-25293138, KAKENHI-PROJECT-26253072, KAKENHI-PROJECT-25560363, KAKENHI-PROJECT-16K09092
[Journal Article] Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up.2016
- Author(s)
  Yokoyama M, Watanabe T, Otaki Y, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Konta T, Shibata Y, Daimon M, Ueno Y, Kato T, Kayama T, Kubota I.
- Journal Title
  
  Dis Markers.
  
  Volume: 4857917. Pages: 4857917-4857917
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253072
[Journal Article] Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study.2016
- Author(s)
  Kamei K, Konta T, Ichikawa K, Sato H, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 20 Pages: 904-909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253072
[Journal Article] Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure.2015
- Author(s)
  Narumi T, Watanabe T, Kadowaki S, Kinoshita D, Yokoyama M, Honda Y, Otaki Y, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
- Journal Title
  
  Cardiovasc Diabetol.
  
  Volume: 13 Pages: 84-84
- DOI
  10.1186/1475-2840-13-84
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461121, KAKENHI-PROJECT-26461122
[Journal Article] High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis.2015
- Author(s)
  Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo C, Abe J, Takeishi Y, Kubota I
- Journal Title
  
  J. Mol. Cell. Cardiol.
  
  Volume: 82 Pages: 1-12
- DOI
  10.1016/j.yjmcc.2015.02.018
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09143, KAKENHI-PROJECT-26461121, KAKENHI-PROJECT-26461122, KAKENHI-PROJECT-26860541, KAKENHI-PROJECT-26870067
[Journal Article] Atrial endothelial impairment through Toll-like receptor 4 signaling causes atrial thrombogenesis2014
- Author(s)
  Katoh S, Honda S, Watanabe T, Suzuki S, Ishino M, Kitahara T, Funayama A, Netsu S, Sasaki T, Shishido T, Miyamoto T, Sadahiro M, Kubota I.
- Journal Title
  
  Heart Vessels
  
  Volume: 29 Pages: 263-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] Senescence marker protein 30 has a cardio-protective role in Doxorubicin-induced cardiac dysfunction.2014
- Author(s)
  Miyata M, Suzuki S, Misaka T, Shishido T, Saitoh S, Ishigami A, Kubota I, Takeishi Y
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0079093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-24659380, KAKENHI-PROJECT-25870584
[Journal Article] Midkine exacerbates pressure overload-induced cardiac remodeling2014
- Author(s)
  Netsu S, Shishido T, Kitahara T, Honda Y, Funayama A, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Arimoto T, Nishiyama S, Watanabe T, Woo CH, Takeishi Y, Kubota I.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 443 Pages: 205-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] Atrial endothelial impairment through Toll-like receptor 4 signaling causes atrial thrombogenesis.2014
- Author(s)
  Katoh S, Honda S, Watanabe T, Suzuki S, Ishino M, Kitahara T, Funayama A, Netsu S, Sasaki T, Shishido T, Miyamoto T, Sadahiro M, Kubota I.
- Journal Title
  
  Heart Vessels.
  
  Volume: 29 Pages: 263-272
- DOI
  10.1007/s00380-013-0369-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591033, KAKENHI-PROJECT-24659380
[Journal Article] Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure.2014
- Author(s)
  Otaki Y, Watanabe T, Takahashi H, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Konta T, Kubota I
- Journal Title
  
  Int J Cardiol
  
  Volume: 173 Pages: 222-228
- DOI
  10.1016/j.ijcard.2014.02.044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461121, KAKENHI-PROJECT-26461122
[Journal Article] Midkine exacerbates pressure overload-induced cardiac remodeling2014
- Author(s)
  Netsu S, Shishido T, Kitahara T, Honda Y, Funayama A, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Arimoto T, Nishiyama S, Watanabe T, Woo CH, Takeishi Y, Kubota I.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 443 Pages: 205-210
- DOI
  10.1016/j.bbrc.2013.11.083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591033, KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-24659380
[Journal Article] Electrocardiographic left ventricular hypertrophy cornell product is a feasible predictor of cardiac prognosis in patients with chronic heart failure.2014
- Author(s)
  Otaki Y, Takahashi H, Watanabe T, Kadowaki S, Narumi T, Honda Y, Hasegawa H, Honda S, Funayama A, Nishiyama, Arimoto T, Shishido T, Miyashita T, Miyamoto T, Kubota I
- Journal Title
  
  Clin Res Cardiol.
  
  Volume: 103 Pages: 275-284
- DOI
  10.1007/s00392-013-0646-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461121, KAKENHI-PROJECT-26461122
[Journal Article] Association of Heart-Type Fatty Acid-Binding Protein with Cardiovascular Risk Factors and All-Cause Mortality in the General Population:The Takahata study2014
- Author(s)
  Yoichiro Otaki,Tetsu Watanabe,Hiroki Takahashi,Atushi Hirayama,Taro Narumi,Shinpei Kadowaki,Yuki Honda,Takanori Arimoto,Tetsuro Shishido,Takuya Miyamoto,Tsuneo Konta,Yoko Shibata,Akira Fukao,Makoto Daimon,Yoshiyuki Ueno,Takeo Kato,Takamasa Kayama,Isao Kubota
- Journal Title
  
  PLOS　ＯＮＥ
  
  Volume: 9 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253072
[Journal Article] Diacylglycerol kinaseαexacerbates cardiac injury after ischemia/reperfusion2014
- Author(s)
  Sasaki T, Shishido T, Kadowaki S, Kitahara T, Suzuki S, Katoh S, Funayama A, Netsu S, Watanabe T, Goto K, Takeishi Y, Kubota I.
- Journal Title
  
  Heart Vessels
  
  Volume: 29 Pages: 110-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure2013
- Author(s)
  Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo CH, Abe J, Kuwahara K, Nakao K, Takeishi Y, Kubota I.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 99 Pages: 657-664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure.2013
- Author(s)
  Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo CH, Abe JI, Kuwahara K, Nakao K, Takeishi Y, Kubota I.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 99 Pages: 657-64
- DOI
  10.1093/cvr/cvt128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-24591033, KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-24659380, KAKENHI-PROJECT-24659386
[Journal Article] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling.2013
- Author(s)
  Misaka T, Suzuki S, Miyata M, Kobayashi A, Shishido T, Ishigami A, Saitoh S, Hirose M, Kubota I, Takeishi Y
- Journal Title
  
  Cardiovasc Res.
  
  Volume: 9 Pages: 461-470
- DOI
  10.1093/cvr/cvt122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-24659380, KAKENHI-PROJECT-25870584
[Journal Article] Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction.2013
- Author(s)
  Misaka T, Suzuki S, Miyata M, Kobayashi A, Ishigami A, Shishido T, Saitoh S, Kubota I, Takeishi Y
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 439 Pages: 142-147
- DOI
  10.1016/j.bbrc.2013.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-24659380, KAKENHI-PROJECT-25870584
[Journal Article] Long Pentraxin PTX3 Exacerbates Pressure Overload-Induced Left Ventricular Dysfunction2013
- Author(s)
  Suzuki S, Shishido T, Funayama A, Netsu S, Ishino M, Kitahara T, Sasaki T, Katoh S, Otaki Y, Watanabe T, Shibata Y, Mantovani A, Takeishi Y, Kubota I.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] The impact of renal tubular damage, as assessed by urinaryβ2-microglobulin-creatinine ratio, on cardiac prognosis in patients with chronic heart failure2013
- Author(s)
  Otaki Y, Watanabe T, Shishido T, Takahashi H, Funayama A, Narumi T, Kadowaki S, Hasegawa H, Honda S, Netsu S, Ishino M, Arimoto T, Miyashita T, Miyamoto T, Konta T, Kubota I.
- Journal Title
  
  Circ Heart Fail
  
  Volume: 6 Pages: 662-668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] Impact of insulin resistance on silent and ongoing myocardial damage in normal subjects: the Takahata study.2012
- Author(s)
  Narumi T, Shishido T, Kiribayashi N, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Shibata Y, Konta T, Ueno Y, Kato T, Kayama T, Kubota I.
- Journal Title
  
  Exp Diabetes Res.
  
  Volume: 2012 Pages: 815098-815098
- DOI
  10.1155/2012/815098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790830, KAKENHI-PROJECT-24659380
[Journal Article] Prognostic value of low left atrial appendage wall velocity in patients with ischemic stroke and atrial fibrillation2012
- Author(s)
  Tamura H, Watanabe T, Nishiyama S, Sasaki S, Wanezaki M, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Kubota I
- Journal Title
  
  J Am Soc Echocardiogr
  
  Volume: 25 Pages: 576-583
- URL
  http://dx.doi.org/10.1016/j.echo.2012.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590923
[Journal Article] Circulating heart-type fatty acid binding protein levels predict the occurrence of appropriate shocks and cardiac death in patients with implantable cardioverter-defibrillators.2012
- Author(s)
  Daidoji H, Arimoto T, Nitobe J, Tamura H, Kutsuzawa D, Ishigaki D, Ishino M, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Journal Title
  
  J Card Fail.
  
  Volume: 18 Pages: 564-569
- DOI
  10.1016/j.cardfail.2012.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659380
[Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event2011
- Author(s)
  Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
- Journal Title
  
  Eur J Clin Invest
  
  Volume: 41 Pages: 759-766
- URL
  http://dx.doi.10.1111/j.1365-2362.2010.02465.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590923
[Journal Article] Increased left atrial volume index predicts a poor prognosis in patients with heart failure2011
- Author(s)
  Tamura H, Watanabe T, Nishiyama S, Sasaki S, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Hirono O, Kubota I
- Journal Title
  
  J Card Fail
  
  Volume: 17 Pages: 210-216
- URL
  http://dx.doi.org/10.1016/j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590923
[Journal Article] Elevated cystatin C levels predict the incidence of vasospastic angina2011
- Author(s)
  Funayama A, Watanabe T, Tamabuchi T, Otaki Y, Netsu S, Hasegawa H, Honda S, Ishino M, Arimoto T, Takahashi H, Shishido T, Miyamoto T, Nitobe J, Kubota I
- Journal Title
  
  Circ J
  
  Volume: 75 Pages: 2439-2444
- NAID
  10029459648
- URL
  http://dx.doi.org/10.1253/circj.CJ-11-0008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590923
[Journal Article] Trends in coronary risk factors among patients with acute myocardial infarction over the last decade : the Yamagata AMI registry2010
- Author(s)
  Nishiyama S, Watanabe T, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Shibata Y, Konta T, Kawata S, Kato T, Fukao A, Kubota I
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 17 Pages: 989-998
- NAID
  130004444462
- URL
  http://dx.doi.org/10.5551/jat.4671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590923
[Journal Article] Cardiac-specific overexpression of diacylglycerol kinase ζ prevents Gq protein coupled receptor agonists-induced cardiac hypertrophy in transgenic mice.2006
- Author(s)
  Arimoto T, Takeishi Y, Takahashi H, Shishido T, Niizeki T, Koyama Y, Shiga R, Nozaki N, Nakajima O, Nishimaru K, Abe JI, Endoh M, Walsh RA, Goto K, Kubota I
- Journal Title
  
  Circulation 113
  
  Pages: 60-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Adenovirus-mediated overexpression of diacylglycerol kinase inhibits endothelin-1-induced cardiomyocyte hypertrophy.2005
- Author(s)
  Takahashi H, Takeishi Y, Seidler T, Arimoto T, Akiyama H, Koyama Y, Shishido T, Tsunoda Y, Niizeki T, Hozumi Y, Abe J, Hasenfuss G, Goto K, Kubota I
- Journal Title
  
  Circulation 111
  
  Pages: 1510-1516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Serum heart-type fatty acid binding protein predicts cardiac events in the elderly chronic heart failure patients.2005
- Author(s)
  Niizeki T, Takeishi Y, Arimoto T, Okuyama H, Takabatake N, Fukui A, Tachibana H, Nozaki N, Hirono O, Tsunoda Y, Miyashita T, Takahashi H, Koyama Y, Shishido T, Kubota I
- Journal Title
  
  J Cardiol 46
  
  Pages: 9-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Ongoing myocardial damage relates to cardiac sympathetic nervous disintegrity in patients with heart failure.2005
- Author(s)
  Arimoto T, Takeishi Y, Niizeki T, Koyama Y, Okuyama H, Nozaki N, HironoO, Tsunoda Y, Miyashita T, Shishido T, Okada A, Takahashi K, Kubota I
- Journal Title
  
  Ann Nucl Med 19
  
  Pages: 535-540
- NAID
  10017672861
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] A Novel Polymorphism in Secretory Phospholipase A2-IID is Associated with Body Weight Loss in COPD.2005
- Author(s)
  Takabatake N, Sata M, Inoue S, Shibata Y, Abe S, Wada T, Machiya JI, Ji G, Matsuura T, Takeishi Y, Muramatsu M, Kubota I
- Journal Title
  
  Am J Respir Crit Care Med
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Toll-like receptor-2 in the pathogenesis of cuff-induced vascularinjury.2005
- Author(s)
  Shishido T, Nozaki N, Miyamoto T, Takahashi H, Arimoto T, Takeishi Y, Kubota I
- Journal Title
  
  Circ J (abstract) 69
  
  Pages: 481-481
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Involvement of pulmonary endothelial cell injury in the pathogenesis of pulmonary fibrosis : clinical assessment by ^<123>I-MIBG lung scintigraphy.2005
- Author(s)
  Takabatake N, Arao T, Sata M, Abe S, Inoue S, Shibata Y, Takeishi Y, Kubota I
- Journal Title
  
  Eur J Nucl Med Mol Imaging 32
  
  Pages: 221-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Importance of pulmonary veins region for atrial tachycardia induction and maintenance in chronic volume overload-induced dilated atria.2005
- Author(s)
  Hirose M, Takeishi Y, Miyamoto T, Kubota I, Laurita KR, Chiba S
- Journal Title
  
  J Cardiovasc Electrophysiol 16
  
  Pages: 760-769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure.2005
- Author(s)
  Arimoto T, Takeishi Y, Shiga R, Fukui A, Tachibana H, Nozaki N, Hirono O, Watanabe T, Nitobe J, Miyamoto T, Kubota I
- Journal Title
  
  J Card Fail 11
  
  Pages: 56-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Cystatin C is a novel predictor of cardiac events in patients with chronic heart failure.2005
- Author(s)
  Arimoto T, Takeishi Y, Niizeki T, Takabatake N, Okuyama H, Fukui A, Tachibana H, Nozaki N, Hirono H, Tsunoda Y, Miyashita T, Shishido T, Takahashi H, Koyama Y, Kubota I
- Journal Title
  
  J Card Fail 11
  
  Pages: 595-601
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] A combination of heart-type fatty acid binding protein and brain natriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure.2005
- Author(s)
  Niizeki T, Takeishi Y, Arimoto T, Takahashi T, Okuyama H, Takabatake N, Nozaki N, Hirono O, Tsunoda Y, Shishido T, Takahashi H, Koyama Y, Fukao A, Kubota I
- Journal Title
  
  Circ J 69
  
  Pages: 922-927
- NAID
  110002696202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits.2005
- Author(s)
  Tasaki K, Wakabayashi I, Shishido T, Takasaki S, Takeishi Y, Kubota I, Ito T, Katano Y, Tomoike H
- Journal Title
  
  J Smooth Muscle Res 41
  
  Pages: 87-97
- NAID
  110002950121
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] C-reactive protein elevation predicts occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation.2005
- Author(s)
  Watanabe T, Takeishi Y, Itoh M, Matsui M, Nakamura K, Tamada Y, Kubota I
- Journal Title
  
  Heart Vessels 20
  
  Pages: 45-49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Pitavastatin inhibits cardiac hypertrophy in a rat model of progressive renal injury.2005
- Author(s)
  Takahashi H, Takeishi Y, Arimoto T, Konta T, Koyama Y, Niizeki T, Kubota I
- Journal Title
  
  J Cardiovasc Pharmacol 46
  
  Pages: 487-493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Dynamic ^<123>I-BMIPP single photon emission computed tomography in patients with congestive heart failure : effect of angiotensin II type-I receptor blockade.2004
- Author(s)
  Takeishi Y, Minamihaba O, Yamauchi S, Arimoto T, Hirono O, Takahashi H, Akiyama H, Miyamoto T, Nitobe J, Nozaki N, Tachibana H, Okuyama M, Fukui A, Kubota I
- Journal Title
  
  Clin Cardiol 27
  
  Pages: 204-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Dynamic ^<123>I-MIBG SPECT reflects sympathetic nervous integrity and predicts clinical outcome in patients with chronic heart failure.2004
- Author(s)
  Arimoto T, Takeishi Y, Fukui A, Tachibana H, Nozaki N, Hirono O, Yamaguchi H, Itoh M, Miyamoto T, Tsunoda Y, Takahashi H, Kubota I, Okada A, Takahashi K
- Journal Title
  
  Ann Nucl Med 18
  
  Pages: 145-150
- NAID
  10017669333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.2004
- Author(s)
  Takahashi H, Takeishi Y, Miyamoto T, Shishido T, Arimoto T, Konta T, Miyashita T, Ito M, Kubota I
- Journal Title
  
  Eur J Clin Invest 34
  
  Pages: 85-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Activation of distinct signal transduction pathways in hypertrophied hearts by pressure and volume overload.2004
- Author(s)
  Miyamoto T, Takeishi Y, Takahashi H, Shishido T, Arimoto T, Tomoike H, Kubota I
- Journal Title
  
  Basic Res Cardiol 99
  
  Pages: 328-337
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Fatty acid metabolism assessed by ^<125>I-iodophenyl 9-methylpentadecanoic acid and expression of fatty acid utilization enzymes in volume- overloaded hearts.2004
- Author(s)
  Miyamoto T, Takeishi Y, Tazawa S, Inoue M, Aoyama T, Takahashi H, Arimoto T, Itoh M, Kubota I, Tomoike H
- Journal Title
  
  Eur J Clin Invest 34
  
  Pages: 176-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Assessment of myocardial involvement in patients with chronic renal failure by ultrasonic tissue characterization and serum markers of collagen metabolism.2004
- Author(s)
  Fatema K, Hirono O, Kaneko K, Takeishi Y, Kubota I
- Journal Title
  
  Clin Cardiol 27
  
  Pages: 228-234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Prominent J wave in the anterior leads in the Brugada syndrome.2004
- Author(s)
  Tsunoda Y, Takeishi Y, Nozaki N, Kitahara T, Kubota I
- Journal Title
  
  J Electrocardiol 37
  
  Pages: 311-314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Journal Article] Modulation of doxorubicin-induced cardiac dysfunction in Toll-like receptor 2 knockout mice.2004
- Author(s)
  Nozaki N, Shishido T, Takeishi Y, Kubota I
- Journal Title
  
  Circulation 110
  
  Pages: 2869-2874
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590657
[Presentation] Platelet to lymphocyte ratio is a feasible predictor for poor outcome in patients with peripheral artery disease after endovascular therapy．2017
- Author(s)
  Yokoyama M，Watanabe T，Takahashi H，Toshima T，Otaki　Y，Tamura　H，Nishiyama S，Arimoto T，Shishido T，Yamauchi　S，Yamanaka　T，Miyamoto T，Kubota I
- Organizer
  第49回日本動脈硬化学会総会
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Myocardial damage markers can risk-stratify aortic aneurysm patients with coronary artery disease．2017
- Author(s)
  4)Watanabe K, Watanabe T, Yamaura G, Wanezaki M, Kutsuzawa D, Iwayama T**, Tamura H, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Yamauchi S, Miyamoto T, Kubota I
- Organizer
  ESC CONGRESS 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Intramuscular fat deposition can predict adverse clinical outcomes in patients with peripheral artery disease．2017
- Author(s)
  Sugai T, Takahashi H, Watanabe K, Toshima T, Takahashi T, Yokoyama M, Kinoshita D, Arimoto T, Shishido T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  ESC CONGRESS 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Ｘanthine　oxidoreductase　plays　a key　role　in　cardio-hepatic　vicious　cycle　in　patients with　heart failure．2017
- Author(s)
  Otaki Y, Watanabe T, Yokoyama M, Kinoshita D, Nishiyama S, Takahasi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
- Organizer
  第21回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] 心筋症患者でのHigh Mobility Group Box 1 (HMGB1)発現とその意義に関する検討2015
- Author(s)
  木下大資，宍戸哲郎，高橋徹也，渡邉哲，久保田功
- Organizer
  日本心不全学会　第1回日本心筋症研究会
- Place of Presentation
  一橋大学（東京都千代田区）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Regression of sokolow-lyon voltage is associated with higher incidence of cardiac events in patients with chronic heart failure.2015
- Author(s)
  Kinoshita D, Shishido T, Takahashi T, Yokoyama M, Narumi T, Kadowaki S, Honda Y, Watanabe T, Kubota I
- Organizer
  ESC CONGRESS 2015
- Place of Presentation
  エクセル・ロンドン（イギリス・ロンドン）
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Serum Uric Acid Lvels are Associated with Myocardial Damage in General Population2014
- Author(s)
  Kadowaki S, Shishido T, Narumi T, Otaki Y, Honda Y, Wanezaki M, Nishiyama S, Arimoto T, Takahashi H, Miyamoto T, Watanabe T, Kubota I
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Association between Emotional Stress Evaluated by Levels of BDNF and the Exacebaiton of Chronic Heart Failure2014
- Author(s)
  Kadowaki S, Shishido T, Kinoshita D, Yokoyama M, Narumi T, Otaki Y, Honda Y, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Cardiac-specific Overexpression of High-mobility Group Box 1 as a Novel Therapeutic Approach for Doxorubicin Cardiomyopathy2014
- Author(s)
  Narumi T, Shishido T, Funayama A, Kadowaki S, Yokoyama M, Kinoshita D, Ohtaki Y, Honda Y, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Relationship Between Uric Acid and Myocardial Damage in General Population2013
- Author(s)
  Shinpei Kadowaki, Tetsuro Shishido, Taro Narumi, Yuki Honda, Yoichiro Otaki, Masahiro Wanezaki, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Takuya Miyamoto, Takehiko Miyashita, Tetsu Watanabe, Isao Kubota
- Organizer
  アメリカ心臓協会学術集会
- Place of Presentation
  ダラスコンベンションセンター（米国　ダラス）
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Cardiac-specific overexpression of high-mobility group box 1 attenuates cardiovascular apoptosis and mitochondrial dysfunction during the pathogenesis of doxorubicin cardiomyopathy2013
- Author(s)
  Narumi T, Kubota I et al.
- Organizer
  American Heart Association Scientific Sessions 2013, Dallas
- Place of Presentation
  USA, (Dallas Convention Center)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Cardiac-specific Overexpression of High-mobility Group Box 1 Attenuates Cardiomyocyte Apoptosis and Mitochondrial Dysfunction During the Pathogenesis of Doxorubicin Cardiomyopathy2013
- Author(s)
  Taro Narumi, Tetsuro Shishido, Akira Funayama, Miyuki Yokoyama, Daisuke Kinoshita, Shinpei Kadowaki, Yuki Honda, Yoichiro Otaki, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takehiko Miyashita, Takuya Miyamoto, Tetsu Watanabe, Isao Kubota,
- Organizer
  アメリカ心臓協会学術集会
- Place of Presentation
  ダラスコンベンションセンター（米国　ダラス）
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Pentraxin 3 is essential for neointima formation after vascular injury2012
- Author(s)
  Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Netsu S, Funayama A, Tamura H, Nishiyama S, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
- Organizer
  The 76th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Fukuoka, Fukuoka International Congress Center
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Overexpression of midkine aggravates cardiac dysfunction and adverse myocardial remodeling induced by pressure overload2012
- Author(s)
  Netsu S, Shishido T, Ishino M, Funayama A, Kadowaki S, Narumi T, Ohtaki Y, Hasegawa H, Honda S, Tamura H, Nishiyama S, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  The 76th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Fukuoka, Fukuoka International Congress Center
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Combination of iodine-123-meta- iodobenzylguanidine imaging and heart-type fatty acid binding protein for risk stratification in heart failure with preserved ejection fraction2012
- Author(s)
  Katoh S, Shishido T, Arimoto T, Kubota I et al.
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles USA, (Los Angeles Convention Center)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Multple kidney biomarkers can risk-stratify chronic heart failure patients2012
- Author(s)
  Kadowaki S, Shishido T, Narumi T, Kubota I et al.
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles USA, (Los Angeles Convention Center)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) prevents cardiac dysfunction induced by pressure overload2012
- Author(s)
  Funayama A, Shishido T, Ishino M, Ohtaki Y, Netsu S, Hasegawa H, Honda S, Kadowaki S, Narumi T, Nishiyama S, Arimoto T, Takiahashi H, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  The 76th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Fukuoka, Fukuoka International Congress Center
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Cardiac-specific overexpression of high-mobility group box 1 protects cardiomyocyte from apoptosis during the pathogenesis of doxorubicin cardiomyopathy2012
- Author(s)
  Narumi T, Shishido T, Kadowaki S, Kubota I et al.
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles USA, (Los Angeles Convention Center)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Cardiac nuclear high mobility group box 1 attenuates cardiac dysfunction induced by pressure overload.2012
- Author(s)
  Funayama A, Shishido T, Watanabe T, Kubota I
- Organizer
  第29回国際心臓研究学会(ISHR)日本部会総会
- Place of Presentation
  九州大学医学部百年講堂 (福岡県)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Left atrial ejection franction is a feasible parameter to predict poor prognosis in patients with heart failure and sinus rhythm2012
- Author(s)
  Sasaki S, Tamura H, Watanabe T, Kubota I et al.
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles USA, (Los Angeles Convention Center)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Cardiac-specific overexpression of high-mobility group box 1 protects cardiomyocyte from apoptosis during the pathogenesis of doxorubicin cardiomyopathy.2012
- Author(s)
  Funayama A, Shishido T, Ishino M, Ohtaki Y, Netsu S, Hasegawa H, Honda S, Kadowaki S, Narumi T, Nishiyama S, Arimoto T, Takiahashi H, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  ﾛｻﾝｾﾞﾙｽｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ (ｶﾘﾌｫﾙﾆｱ､ｱﾒﾘｶ)
- Data Source
  KAKENHI-PROJECT-24659380
[Presentation] Midkine exacerbates cardiac hypertrophy and remodeling in response to pressure overload2011
- Author(s)
  Netsu S, Shishido T, Ishino M, Kadowaki S, Narumi T, Otaki Y, Funayama A, Honda S, Hasegawa H, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Kubota I
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando , America
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Deficiency of the long pentraxin PTX3 deteriorates neointimal hyperplasia after vascular injury2011
- Author(s)
  Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Netsu S, Funayama A, Arimoto T, Nishiyama S, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando ,America
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) attenuates cardiac dysfunction induced by pressure overload2011
- Author(s)
  Funayama A, Shishido T, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo CH, Kuwahara K, Nakao K, Takeishi Y, Kubota I
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando, America
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Atrial endothelial impairment through toll-like receptor-4 signaling may cause atrial thrombogenesis2010
- Author(s)
  Kato S, Watanabe T, Suzuki S, Ishino M, Sasaki T, Shishido T, Sadahiro M, Kubota I
- Organizer
  XXth World Congress of the International Society for Heart Research 2010, Kyoto
- Place of Presentation
  Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-21590923
[Presentation] Senescence marker protein 30 protect the cardiac injury from after ischemia reperfusion.
- Author(s)
  Kadowaki S, Shishido T, Narumi T, Honda Y, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  マコーミックプレイスコンベンションセンター(アメリカ合衆国シカゴ）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Impact of fat free mass on cardiac prognosis in patients with heart failure.
- Author(s)
  Narumi T, Watanabe T, Takahashi T, Yokoyama M, Kinoshita D, Kadowaki S, Honda Y, Otaki Y, Kubota I
- Organizer
  ESC CONGRESS 2014.
- Place of Presentation
  Fira Gran Via（スペイン,バルセロナ)
- Year and Date
  2014-08-31 – 2014-09-02
- Data Source
  KAKENHI-PROJECT-26461122
[Presentation] Narrowing of retinal arterioles might reflect smoking sensitivity, a risk of chronic obstructive pulmonary disease.
- Author(s)
  Hirayama A, Kawasaki R, Shibata Y, Konta T, Narimatsu H, Kayama T, Yamashita H, Kubota I,
- Organizer
  The Association for Research in Vision and Ophthalmology 2014 Annual Meeting
- Place of Presentation
  オレンジカントリーコンベンションセンター（アメリカ合衆国オーランド）
- Year and Date
  2014-05-04 – 2014-05-08
- Data Source
  KAKENHI-PROJECT-26461122

1. TOMOIKE Hitonobu (90112333)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. YAMAKI Michiyasu (40191217)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. IKEDA Kozue (30184419)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. TAKEISHI Yasuchika (40272067)

# of Collaborated Projects: 4 results

# of Collaborated Products: 28 results
5. YAMAGUCHI Seiji (30239892)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SHISHIDO Tetsuro (60400545)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
7. TONOOKA Ichiro (70164001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SHIRAKABE Masanori (10241697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TSUIKI Kai (30004683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OHTA Ikurou (70143097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. NAKAMURA Hidenori (30240675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MIYAWAKI Hiroshi (30261704)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. WATANABE Tetsu (40359568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
14. OGUMA Masaki (10160821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OKAZAKI Mitsuyo (20013998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OOWADA Kazuo (60101010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YASUI Shoji (20023781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Hirayama Atsushi (20637350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KAYAMA Takamasa (50142972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
20. YAMASHITA Hidetoshi (90158163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. NEMOTO Kenji (10208291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
22. SATO Shinya (00302290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
23. MURAKAMI Masayasu (00577760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TOGASHI Hitoshi (60192209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. FUKAO Akira (80156736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
26. NAKAJIMA Osamu (80312841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KITANAKA Chihumi (70260320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. UENO Yoshiyuki (70282126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
29. SUZUKI Kyoko (20271934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. KATO Takeo (90194828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
31. KOKUBO Yasuaki (40343074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KAWASAKI Ryo (70301067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
33. Narimatsu Hiroto (50524419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
34. 熱海裕之 (60151081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 細谷幸雄 (10250945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 中島豊 (50135349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 楢林英樹 (90208083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 稲生哲治 (10159965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 吉村哲彦 (70271517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. INOUE Sumito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. NAKAMURA Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 錦見俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 桑原宏一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
45. 石神昭人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
46. 今田恒夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 大門真

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 柴田陽光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 阿部修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 五十嵐朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 長谷川寛真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 田中敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBOTA Isao 久保田 功

久保田 功 クボタ イサオ

Research Projects

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Co-Researchers

Relationship between deacetylation of nuclear High-Mobility Group Box 1 and Sirt7 activation in failing heartPrincipal Investigator

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The role of HMGB1 in regulating mitochondrial dysfunction induced by agingPrincipal Investigator

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Development of treatment of heart failure targetting at chronic organ damage and chromatin remodelingPrincipal Investigator

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Impact of HMGB1 on left ventricular remodeling after myocardial infarction : Novel therapeutic target for neovascularizationPrincipal Investigator

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High-mobility group box 1 restores cardiac dysfunction after myocardial infarction in transgenic micePrincipal Investigator

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Role of Toll-like receptor in cardiovascular remodelingPrincipal Investigator

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急性虚血・再灌流心に生ずるK^+チャネル活性変動の経時的,3次元的評価Principal Investigator

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虚血心におけるK^+チャネル活性変動に関する実験的研究Principal Investigator

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KUBOTA Isao 久保田功

久保田功クボタイサオ