Kuge Osamu 久下理

… Alternative Names

KUGE Osamu 久下理

久下理クゲオサム

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Researcher Number	30177977
External Links
Affiliation (based on the past Project Information) *help	2016 – 2022: 九州大学, 理学研究院, 教授 2011 – 2013: 九州大学, 理学(系)研究科(研究院), 教授 2009: Kyushu University, 大学院・理学研究院, 教授 2007 – 2009: Kyushu University, 理学研究院, 教授 2004 – 2005: 九州大学, 大学院・理学研究院, 教授 … More 2003: 九州大学, 理学研究院, 教授 1999 – 2002: 国立感染症研究所, 細胞化学部, 室長 1996 – 1997: National Institute of Health Department, Biochemistry and Cell Biology Title of Position, Laboratory Chief, 細胞化学部, 室長 1994 – 1996: 国立予防衛生研究所, 細胞化学部, 室長 1993: 国立予防衛生研究所, 細胞化学部, 主任研究官 1989: 国立予防衛生研究所, 化学部, 研究員 1986 – 1987: 国立予防衛生研究所, 化学部, 研究員 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy / Basic Section 44010:Cell biology-related / Cell biology / Cell biology / Functional biochemistry Except Principal Investigator Biological pharmacy / Structural biochemistry
Keywords	Principal Investigator リン脂質 / ホスファチジルセリン / 細胞内輸送 / 代謝調節 / ミトコンドリア / 生体膜 / 生合成 / Phosphatidylserine / Phospholipid / カルジオリピン … More / ホスファチジルエタノールアミン / 小胞体 / リン脂質代謝 / オルガネラ形成 / Mdm35 / Ups2 / リン脂質輸送 / ホスファチジン酸 / 輸送 / 代謝 / intracellular transport / metabolic regulation / biosynthesis / phosphatidylserine / phospholipids / 生合成酵素 / CHO細胞 / ホスファチジルエタノールア / 変異株 / 生合性 / 脂質 / Transport / Biosynthesis / ホスファチシルセリン / 酵母 / 細胞生物学 … More Except Principal Investigator LPS / ホスファチジルセリン / CHO cell / MD-2 / Toll-like receptor / sphingolipid / phosphatidylserine / マクロファージ / LCB1 / スフィンゴ脂質 / スフィンゴミエリン / CHO細胞 / リン脂質 / phospholipid metabolism / phospholipid-base exchange enzyme / macrophage / enveloped RNA virus / mammalian cell variant / ホスホリパーゼ / ホスファチジルセリン合成系 / 脂質塩基交換反応 / RAW264細胞株 / ホスホリパーゼA_2 / リン脂質代謝 / リン脂質塩基交換酵素 / 被膜RNAウィルス / CHO細胞株 / 動物細胞変異株 / Flavolipin / Taxol / khafrefungin / phospholipids / Baculovirus / ホスホリパーゼC / 熱帯熱マラリア原虫 / コレステロール / lipid raft / シンドビスウィルス / アミノ含有脂質 / アラニンスキャン法 / TLR4 / カフレファギン / 抗真菌剤 / フラボリピン / タキソール / カフレファンギン / バキュロウイルス / phosphatidylcholine / phospholipase D / cardiolipin / NK-κB / ホスァチジルセリン / NF-κB / CD14 / ホスファチジルグリセロールリン酸 / RhoA / ホスフォリパーゼD / LCB2 / SPT(セリンパルミトイルトランスフェラーゼ) / ホスファチジルコリン / ホスフォリバーゼD / カルジオリピン / ホスファチジルグリセリン / chaperone / protein degradation / quality control / endoplasmic reticulum / システインプロテアーゼ / シャペロン / タンパク質分解 / クオリティコントロール / 小胞体 / Phosphatidylserine / Membrane permeability / Macrophage / Mutant / Phospholipid / Mammalian cells / ホスホリパ-ゼA_2 / アラキドン酸 / ホスファチジルイノシト-ル / 細胞表面膜透過性 / マクロファ-ジ系細胞 / 変異株 / 動物細胞 Less

Intracellular transport and metabolism of phospholipids involved in mitochondrial formation, and elucidation of pathological conditions caused by their damagePrincipal Investigator
- Principal Investigator
  
  Kuge Osamu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyushu University
Intramitochondrial transport and metabolism of phospholipidsPrincipal Investigator
- Principal Investigator
  
  Kuge Osamu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University
Intracellular transport of phospholipidsPrincipal Investigator
- Principal Investigator
  
  KUGE Osamu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University
Study on metabolic control and intracellular transport of phospholipidsPrincipal Investigator
- Principal Investigator
  
  KUGE Osamu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University
Metabolic regulation and intracellular transport of phospholipids in mammalian cellsPrincipal Investigator
- Principal Investigator
  
  KUGE Osamu
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  KYUSHU UNIVERSITY
  National Institute of Infectious Diseases
The role of host cell membrane lipids in infection of microorganisms and in host defense mechanisms
- Principal Investigator
  
  NISHIJIMA Masahiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
Biosymthetic Regulation and Intracellular Transport of PhosphatidylserinePrincipal Investigator
- Principal Investigator
  
  KUGE Osamu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
Studies of quality control of proteins in the endoplasmic reticulum.
- Principal Investigator
  
  KITO Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  KYOTO UNIVERSITY
genetic and biochemical study on intracellular lipid transport and lipid functions in microdomain
- Principal Investigator
  
  NISHIJIMA Masahiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
Genetic and Biochemical Study of Phosphatidylserine biosynthesis and its regulation in animal cellsPrincipal Investigator
- Principal Investigator
  
  KUGE Osamu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health
動物細胞におけるホスファチジルセリンの代謝調節と細胞内輸送に関する研究Principal Investigator
- Principal Investigator
  
  久下理
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  国立予防衛生研究所
動物細胞における細胞内リン脂質輸送機構に関する遺伝生化学的研究Principal Investigator
- Principal Investigator
  
  久下理
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  国立予防衛生研究所
Studies on the regulatory mechanisms and the biological significance of metabolisms of membrane phospholipids in mammalian cells by using technics of biochemical genetics.
- Principal Investigator
  
  AKAMATSU Yuzuru
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health, Japan
Studies on the regulatory mechanisms of phospholipid metabolism and membrane functions by using cultured mammalian cell variants defective in phospholipid biosynthesis.
- Principal Investigator
  
  AKAMATSU Yuzuru
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health, Japan

[Journal Article] Mitochondrial phosphatidylethanolamine synthesis affects mitochondrial energy metabolism and quiescence entry through attenuation of Snf1/AMPK signaling in yeast2022
- Author(s)
  Miyata Non、Ito Takanori、Nakashima Miyu、Fujii Satoru、Kuge Osamu
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 7
- DOI
  10.1096/fj.202101600rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06643, KAKENHI-PROJECT-19H03226
[Journal Article] Topology of phosphatidylserine synthase 1 in the endoplasmic reticulum membrane2021
- Author(s)
  Non Miyata and OsamuKuge
- Journal Title
  
  Protein Science
  
  Volume: 30 Issue: 11 Pages: 2346-2353
- DOI
  10.1002/pro.4182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03226, KAKENHI-PROJECT-20K06643
[Journal Article] Fmp30, MDM31, and Mdm32 function in Ups1-independent cardiolipin accumulation under low phosphatidylethanolamine conditions2018
- Author(s)
  Miyata Non、Kuge Osamu
- Journal Title
  
  Contact
  
  Volume: 1
- DOI
  10.1177/2515256418764043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07354
[Journal Article] Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast2018
- Author(s)
  Miyata Non、Fujii Satoru、Kuge Osamu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 45 Pages: 17593-17605
- DOI
  10.1074/jbc.ra118.005410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15120, KAKENHI-PROJECT-16K07354
[Journal Article] Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae2017
- Author(s)
  Miyata Non、Goda Naoto、Matsuo Keiji、Hoketsu Takeshi、Kuge Osamu
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1 Pages: 16447-16447
- DOI
  10.1038/s41598-017-16661-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07354, KAKENHI-PROJECT-17K15120
[Journal Article] Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria2016
- Author(s)
  Miyata N., Watanabe Y., Tamura Y., Endo T., and Kuge O
- Journal Title
  
  J. Cell Biol.
  
  Volume: 214 Pages: 77-88
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K07354
[Journal Article] ミトコンドリアにおけるリン脂質の生合成2014
- Author(s)
  久下　理
- Journal Title
  
  医学のあゆみ
  
  Volume: 248 Pages: 1159-1165
- Data Source
  KAKENHI-PROJECT-23590080
[Journal Article] Involvement of Sac1 phosphoinositide phosphatase in the metabolism of phosphatidylserine in the yeast Saccharomyces cerevisiae.2014
- Author(s)
  Tani M, Kuge O.
- Journal Title
  
  Yeast
  
  Volume: 31 Issue: 4 Pages: 145-158
- DOI
  10.1002/yea.3004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590080
[Journal Article] ミトコンドリアにおけるリン脂質の生合成医学のあゆみ2014
- Author(s)
  久下理
- Volume
  248
- Pages
  1159-65
- URL
  http://www.ishiyaku.co.jp/magazines/ayumi
- Data Source
  KAKENHI-PROJECT-23590080
[Journal Article] Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.2013
- Author(s)
  Tamura Y, Harada Y, Nishikawa S, Yamano K, Kamiya M, Shiota T, Kuroda T, Kuge O, Sesaki H, Imai K, Tomii K, Endo T.
- Journal Title
  
  Cell Metab.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590080
[Journal Article] Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria2013
- Author(s)
  Y. Tamura, Y. Harada, S. Nishikawa, K. Yamano, M. Kamiya, T. Shiota, T. Kuroda, O. Kuge, H. Sesaki, K. Imai, K. Tomii, and T. Endo
- Journal Title
  
  Cell Metab.
  
  Volume: 17 Issue: 5 Pages: 709-718
- DOI
  10.1016/j.cmet.2013.03.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22227003, KAKENHI-PROJECT-23570051, KAKENHI-PROJECT-23590080, KAKENHI-PUBLICLY-25120711
[Journal Article] Involvement of complex sphingolipids and phosphatidylserine in endosomal trafficking in yeast Saccharomyces cerevisiae.2012
- Author(s)
  Tani M, Kuge O.
- Journal Title
  
  Mol Microbiol.
  
  Volume: 86 Issue: 5 Pages: 1262-1280
- DOI
  10.1111/mmi.12057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590080
[Journal Article] Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae2012
- Author(s)
  Tani M, Kuge O.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 417 Pages: 673-678
- NAID
  120005324445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590080
[Journal Article] Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae2012
- Author(s)
  Tani M, Kuge O
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 417 Issue: 2 Pages: 673-678
- DOI
  10.1016/j.bbrc.2011.11.138
- NAID
  120005324445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770217, KAKENHI-PROJECT-23590080
[Journal Article] The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes.2010
- Author(s)
  Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M.-O., Tomohiro, S., Kuge, O., Baudier, J.
- Journal Title
  
  Mol. Cell Biol. 30
  
  Pages: 1984-1996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590068
[Journal Article] Identification of a novel gene involved in cardiolipin metabolism and mitochondrial morphology in the yeast Saccharomyces cerevisiae.2009
- Author(s)
  Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S., Kuge, O.
- Journal Title
  
  Chemistry and Physics of Lipids 160
  
  Pages: 29-29
- Data Source
  KAKENHI-PROJECT-19590068
[Journal Article] Purification and characterization of human phosphatidylserine synthases 1 and 22009
- Author(s)
  Tomohiro, S., Kawaguti, A., Kawabe, Y., Kitada, S., Kuge, O.
- Journal Title
  
  Biochem. J. 418
  
  Pages: 421-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590068
[Journal Article] ホスファチジルセリンの代謝調節とオルガネラ間輸送2009
- Author(s)
  久下理
- Journal Title
  
  オレオサイエンス第9巻
  
  Pages: 455-464
- NAID
  130004853513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590068
[Journal Article] Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membrane.2009
- Author(s)
  Tani, M., Kuge, O.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 381
  
  Pages: 328-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590068
[Journal Article] Biosynthetic regulation of phospholipids in mammalian cells2006
- Author(s)
  Kuge, O
- Journal Title
  
  Jiken-igaku 24
  
  Pages: 924-928
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] 哺乳動物細胞におけるリン脂質の生合成制御2006
- Author(s)
  久下理
- Journal Title
  
  実験医学 24
  
  Pages: 924-928
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Phosphatidylserine synthase of mammalian cells2005
- Author(s)
  Kuge, O.
- Journal Title
  
  Circular of the Japanese conference on the biochemistry of lipids
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] 動物細胞のホスファチジルセリン合成酵素2005
- Author(s)
  久下理
- Journal Title
  
  脂質生化学研究 Circular 2005
  
  Pages: 25-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis2004
- Author(s)
  Ohsawa, T., Nishijima, M., Kuge, O.
- Journal Title
  
  Biochem.J. 381
  
  Pages: 853-859
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Functional analysis of Chinese hamster phosphatidylserine synthase 1 through synstematic alanine mutagenesis2004
- Author(s)
  Ohsawa, T., Nishijima, M., Kuge, O.
- Journal Title
  
  Biochem.J. 381
  
  Pages: 853-859
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells2003
- Author(s)
  Kuge, O., Nishijima, M.
- Journal Title
  
  J.Biochem. 133
  
  Pages: 397-403
- NAID
  50000824883
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Purification and characterization of Chinese hamster phosphatidylserine synthase 22003
- Author(s)
  Osamu Kuge
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 42692-42698
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Purification and characterization of Chinese hamster phosphatidylserine synthase 22003
- Author(s)
  Kuge, O., Hasegawa, K., Ohsawa, T., Saito, K., Nishijima, M.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 42692-42698
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells2003
- Author(s)
  Osamu Kuge
- Journal Title
  
  J.Biochem. 133
  
  Pages: 397-403
- NAID
  50000824883
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Journal Article] Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter
- Author(s)
  Saito, K., Nishijima, M., Kuge, O.
- Journal Title
  
  Biochem.Biophys.Res.Commun. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380341
[Presentation] ERMESを介した小胞体ーミトコンドリア間PS輸送のin vivo評価系の確立2022
- Author(s)
  田中柊也、三浦宗太郎、藤井悟、宮田暖、久下理
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] 出芽酵母ホスファチジルセリン脱炭酸酵素Psd1の小胞体とミトコンドリアへの局在制御2022
- Author(s)
  藤井悟、宮田暖、久下理
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] 出芽酵母における小胞体-ミトコンドリア間リン脂質輸送経路の解析2021
- Author(s)
  田中柊也、三浦宗太郎、宮田暖、久下理
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] ミトコンドリアPEによる細胞機能制御2021
- Author(s)
  宮田暖、伊藤貴紀、中島未由、久下理
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] ミトコンドリア由来ホスファチジルエタノールアミンによる静止期細胞分化制御2021
- Author(s)
  宮田暖、伊藤貴紀、久下理
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] 出芽酵母のホスファチジルエタノールアミン生合成における小胞体膜タンパク質Ice2の機能解析2020
- Author(s)
  藤井悟、宮田暖、久下理
- Organizer
  第９３回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] 出芽酵母においてポストダイオキシックシフト期に増加するホスファチジルエタノールアミンの機能解析2020
- Author(s)
  宮田暖、伊藤貴紀、久下理
- Organizer
  第６２回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] ミトコンドリア由来ホスファチジルエタノールアミンを介した細胞周期と分化の制御2020
- Author(s)
  宮田暖、伊藤貴紀、久下理
- Organizer
  第９３回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] Porinを介したミトコンドリアリン脂質合成制御2019
- Author(s)
  宮田暖, 藤井悟, 久下理
- Organizer
  第61回日本脂質生化学
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] 出芽酵母の細胞内リン脂質代謝における小胞体膜タンパク質Ice2の機能解明2019
- Author(s)
  藤井悟, 宮田暖, 久下理
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] Multiple functions of an ER membrane protein, Ice2, in phosphatidylethanolamine and phosphatidylcholine biosynthesis in yeast2019
- Author(s)
  Satoru Fujii, Non Miyata, Osamu Kuge
- Organizer
  60th International conference on the bioscience of lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] Porinを介したミトコンドリアリン脂質合成制御2019
- Author(s)
  宮田暖, 藤井悟, 久下理
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03226
[Presentation] Novel functions of porin proteins in mitochondrial phospholipid metabolism.2018
- Author(s)
  Non Miyata, Osamu Kuge
- Organizer
  International conference on the bioscience of lipids 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] 小胞体からミトコンドリアへのホスファチジルセリン輸送に関与する新規酵母遺伝子の探索2018
- Author(s)
  藤井悟、宮田暖、久下理
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] 小胞体からミトコンドリア内膜へのリン脂質輸送に関与する新規因子の探索2018
- Author(s)
  藤井悟、宮田暖、久下理
- Organizer
  第６０回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] ホスファチジルセリンのミトコンドリア外膜・内膜への輸送に関与する新規酵母遺伝子の同定2018
- Author(s)
  藤井悟、宮田暖、久下理
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] ミトコンドリア内リン脂質輸送と生合成2017
- Author(s)
  久下　理、宮田　暖
- Organizer
  2017年度　生命科学系学会合同年次大会（第90回日本生化学会大会）
- Invited
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] 新規ミトコンドリア内リン脂質輸送因子の同定2017
- Author(s)
  宮田　暖、久下　理
- Organizer
  2017年度　生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] Ups1非依存経路によるカルジオリピンの合成と蓄積2017
- Author(s)
  合田　尚人、宮田　暖、法華津　雄士、松尾　慶次、久下　理
- Organizer
  2017年度　生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] Intramitochondrial transport of phosphatidylserine by Ups2-Mdm352016
- Author(s)
  Kuge O. and Miyata N.
- Organizer
  第89回日本生化学会
- Place of Presentation
  東北大学（仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K07354
[Presentation] 酵母ホスホイノシチドホスファターゼSAC1欠損によるホスファチジルセリン量低下のメカニズム解析2013
- Author(s)
  谷元洋, 久下理
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 酵母ホスファチジルセリン脱炭酸酵素2の活性発現に関与する新規遺伝子の同定と解析2012
- Author(s)
  久下理、三好琢弥、山口剛典、谷元洋
- Organizer
  日本脂質生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 出芽酵母の生育阻害誘導に必要なセラミドの構造的要因の解析2012
- Author(s)
  谷元洋, 久下理
- Organizer
  日本脂質生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] ミトコンドリア新規形態制御因子IAT1の解析2012
- Author(s)
  友廣志穂、大橋順、前田敏孝、山本祐華、谷元洋、久下理
- Organizer
  日本生化学会九州支部例会
- Place of Presentation
  福岡
- Year and Date
  2012-05-27
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 複合スフィンゴ脂質とホスファチジルセリンによるエンドソームリサイクリング経路の制御機構2012
- Author(s)
  谷元洋, 久下理
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] リサイクリングエンドソームのホスファチジルセリンは逆行性膜輸送に必要である2011
- Author(s)
  李尚憲、内田安則、久下理、田口友彦、新井洋由
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 出芽酵母のエンドソーム・ゴルジ間輸送における複合スフインゴ脂質とホスファチジルセリンの機能2011
- Author(s)
  谷元洋, 久下理
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 酵母ホスファチジルセリン脱炭酸酵素２の活性に関与する新規遺伝子（GIP3）の同定と解析2011
- Author(s)
  三好琢弥、中嶋友博、谷元洋、久下理
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 酵母ホスファチジルセリン脱炭酸酵素2の活性に関与する新規遺伝子(GIP3)の同定と解析2011
- Author(s)
  三好琢弥、中嶋友博、谷元洋、久下理
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 出芽酵母のエンドソーム・ゴルジ間輸送における複合スフインゴ脂質とホスファチジルセリンの機能2011
- Author(s)
  谷元洋、久下理
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] カルジオリピン代謝に関与する新しい酵母遺伝子の同定と機能解析2009
- Author(s)
  久下理
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19590068
[Presentation] Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes2009
- Author(s)
  Tani, M., Kuge O.
- Organizer
  5the International Charleston Ceramide Conference
- Place of Presentation
  Charleston, SC, USA
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590068
[Presentation] Identification of novel genes involved in the phospholipid transport or metabolism in the yeast Saccharomyces cerevisiae.2009
- Author(s)
  KUGE, O.
- Organizer
  4th International Conference on Phospholipase A2 and Lipid Mediators.
- Place of Presentation
  Tokyo Invited
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-19590068
[Presentation] リン脂質代謝・細胞内輸送に関与する新しい酵母遺伝子の検索と性状解析2008
- Author(s)
  久下理
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19590068
[Presentation] リン脂質代謝・輸送に関与する酵母新規遺伝子の検索と性状解析2007
- Author(s)
  久下理
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590068
[Presentation] 複合スフィンゴ脂質とホスファチジルセリンによるエンドソームリサイクリング経路の制御機構
- Author(s)
  谷元洋、久下理
- Organizer
  日本生化学会大会
- Place of Presentation
  九州大学（福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 酵母ホスファチジルセリン脱炭酸酵素２の活性発現に関与する新規遺伝子の同定と解析
- Author(s)
  久下理、三好琢弥、山口剛典、谷元洋
- Organizer
  日本脂質生化学会
- Place of Presentation
  九州大学（福岡市）
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 酵母ホスホイノシチドホスファターゼSAC1欠損によるホスファチジルセリン量低下のメカニズム解析
- Author(s)
  谷　元洋、久下　理
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] ミトコンドリア新規形態制御因子IAT1の解析
- Author(s)
  友廣志穂、大橋順、前田敏孝、山本祐華、谷元洋、久下理
- Organizer
  日本生化学会九州支部例会
- Place of Presentation
  福岡大学（福岡市）
- Data Source
  KAKENHI-PROJECT-23590080
[Presentation] 出芽酵母の生育阻害誘導に必要なセラミドの構造的要因の解析
- Author(s)
  谷元洋、久下理
- Organizer
  日本脂質生化学会
- Place of Presentation
  九州大学（福岡市）
- Data Source
  KAKENHI-PROJECT-23590080
[]

1. NISHIJIMA Nasahiro (60072956)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KUZE Yohko (50178000)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SAITO Kyoko (70235034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. AKAMATSU Yuzuru (00072900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. AMANO Fumio (90142132)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TANAKA Yasuhito (30113484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KITAGAWA Takayuki (80092188)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KAWASAKI Kiyosi (60270641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HANADA Kentaro (30192701)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 宮田暖 (10529093)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
11. KITADA Sakae (20284482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. KITO Makoto (60027183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SATO Ryuichiro (50187259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKANO Akihiko (90142140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOHNO Kenji (50142005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IKEHARA Yukio (70037612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KIKUCHI Masakazu (10278492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. FUKASAWA Masayoshi (20291130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 宮田愛彦 (70209914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TANI Motohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 遠藤斗志也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 田村康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 西川周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuge Osamu 久下 理

KUGE Osamu 久下 理

久下 理 クゲ オサム

Research Projects

Research Products

Co-Researchers

Intracellular transport and metabolism of phospholipids involved in mitochondrial formation, and elucidation of pathological conditions caused by their damagePrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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Intramitochondrial transport and metabolism of phospholipidsPrincipal Investigator

Principal Investigator

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Intracellular transport of phospholipidsPrincipal Investigator

Principal Investigator

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Study on metabolic control and intracellular transport of phospholipidsPrincipal Investigator

Principal Investigator

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Metabolic regulation and intracellular transport of phospholipids in mammalian cellsPrincipal Investigator

Principal Investigator

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The role of host cell membrane lipids in infection of microorganisms and in host defense mechanisms

Principal Investigator

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Biosymthetic Regulation and Intracellular Transport of PhosphatidylserinePrincipal Investigator

Principal Investigator

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Studies of quality control of proteins in the endoplasmic reticulum.

Principal Investigator

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genetic and biochemical study on intracellular lipid transport and lipid functions in microdomain

Principal Investigator

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Genetic and Biochemical Study of Phosphatidylserine biosynthesis and its regulation in animal cellsPrincipal Investigator

Principal Investigator

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Research Institution

動物細胞におけるホスファチジルセリンの代謝調節と細胞内輸送に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

動物細胞における細胞内リン脂質輸送機構に関する遺伝生化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Studies on the regulatory mechanisms and the biological significance of metabolisms of membrane phospholipids in mammalian cells by using technics of biochemical genetics.

Principal Investigator

Kuge Osamu 久下理

KUGE Osamu 久下理

久下理クゲオサム