IKEHARA Yukio 池原征夫

Researcher Number	70037612
External Links
Affiliation (based on the past Project Information) *help	2006: Daiichi University, Pharmaceutical Science, Professor, 薬学部, 教授 2003 – 2005: 福岡大学, 医学部, 教授 1987 – 2001: Fukuoka University School of Medicine, 医学部, 教授 1986: 福岡大, 医学部, 教授 1985: 福岡大学, 医, 教授
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Cell biology / Structural biochemistry Except Principal Investigator Cell biology / Structural biochemistry / 代謝生物化学 / 広領域
Keywords	Principal Investigator GCP16 / GCP60 / GCP170 / p115 / Giantin / 補体成分C3 / 糖鎖構造 / Dipeptidyl peptidase IV / COG複合体 / cDNAクロ-ニング … More Except Principal Investigator CEA / 小胞体 / GPI-アンカー / 腫瘍マ-カ- / 癌特異性 / 大腸癌 / 腫瘍マーカー / NCA / エンドソ-ム / 癌血清診断 / リソソーム / 分子認隣 / エンドサイト-シス / システインプロテアーゼ / 大腸粘膜crypt / 癌糖鎖特異的モノクロン抗体 / Hydrophobic Anchor / Endoplasmic reticulum / 抗原決定基 / BGP / quality control / endoplasmic reticulum / 細胞接着活性 / Molecular recognition / ゴルジ装置 / Membranous Proteins / 小胞輸送 / protein degradation / Cell organelle / 発作性夜間血色素尿症 / シャペロン / 癌遺伝子導入糖鎖変化 / エキソサイトーシス / 癌マーカー / Peroxisame / 細胞オルガネラ / 選別シグナル / Nucleus / chaperone / タンパク質分解 / 核 / モノクロ-ナル抗体 / Phosphatidylinositol / ペルオキシソ-ム / Lysosome / 蛋白質膜透過 / ゴルジ体 / 蛋白質輸送 / GPIアンカー / carcinoembryonic antigen(CEA) / 疎水性アンカ- / 糖転移酵素 / ホスファチジルイノシト-ル / 膜蛋白質 / PIアンカ- / GPI anchor / 癌特異的抗原性 / glycolipid anchor / ミトコンドリア / 糖蛋白質 / クオリティコントロール / 細胞オルがネラ / Endosome / 大腸粘膜上皮細胞 / 正常糞便抗原 / 正常大腸粘膜のCEA産生 / 正常大腸粘膜 / PI Anchor / 癌胎児性抗原 / PI:アンカ- / GPI結合型蛋白質 / エンドサイトーシス / 分子認識 / GPI型膜結合 / PNH / 蛋白質選別輸送 / リソソ-ム / 糖脂質 / Mitochondrion / 形質膜 / リソゾ-ム / 細胞表面糖鎖 Less

Identification and characterization of factors required for the Golgi structurePrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Daiichi University
  Fukuoka University
Identification and characterization of proteins required for the Golgi structurePrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Fukuoka University
Molecular mechanisms for vesicular transport and Golgi structure formationPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka University
Study on the topology of the GPI anchor assembly
- Principal Investigator
  
  HIROSE Shinichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Fukuoka University
糖脂質(GPI)転移酵素の同定と遺伝子クローニングPrincipal Investigator
- Principal Investigator
  
  池原征夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fukuoka University
Studies of quality control of proteins in the endoplasmic reticulum.
- Principal Investigator
  
  KITO Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  KYOTO UNIVERSITY
CEAの癌特異性の解明:大腸粘膜におけるその産生動態の生理と病理
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
CEAの癌特異性の解明:大腸粘膜におけるその産生動態の生理と病理
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
小胞体経路の蛋白質選別輸送の分子機構
- Principal Investigator
  
  大村恒雄
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
CEAの癌特異性の解明:大腸粘膜におけるその産生動態の生理と病理
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
粘膜上皮細胞の分化並びに癌化に伴うCEA及び関連抗原の産生動態の変化
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
Posttranslational Modifications of Proteins during Intracellular TransportPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukuoka University
癌胎児性抗原(CEA)の癌特異性の本態の解明
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
The Biological Significance of PI as the Hydrophobic Anchor for Membranous Proteins
- Principal Investigator
  
  IKEZAWA Hiroh
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Nagoya City University
Molecular Recognition Involved in the Formation of Cell Organelles.
- Principal Investigator
  
  KATO Keitaro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  代謝生物化学
- Research Institution
  Kyushu University
Structural Features, Biosynthesis and Processing of Glycolipid-anchored ProteinsPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukuoka University
癌の細胞膜糖鎖変化の機構と応用に関する研究
- Principal Investigator
  
  牧田章
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
Biosynthesis and Intracellular Modifications of Plasma ProteinsPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukuoka University
分泌阻害剤の応用による分泌蛋白質プロセシングの解析Principal Investigator
- Principal Investigator
  
  池原征夫
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Fukuoka University

All 2007 2006 2005 2004 2003

All Journal Article Book

[Book] The Handbook of Proteolytic Enymes (2^<nd> edition) (A.J.Barrett et al., eds.) (Dipeptidyl-peptidases A and B)2004
- Author(s)
  Misumi, Y., Ikehara, Y.
- Publisher
  Elsevier Chapter 593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Book] The Handbook of Proteolytic Enzymes (2^<nd> Edition) (分担) Chapter 593. Dipeptidyl-peptidases A and B(A.J.Barrett, N.D.Rawrings and J.F.Woessner, eds.)2004
- Author(s)
  Y.Misumi, Y.Ikehara
- Publisher
  Elsevier/Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Book] The Handbook of Proteolytic Enymes (2^<nd> edition) (A.J.Barrett et al., eds.) (Dipeptidyl-peptidase IV)2004
- Author(s)
  Misumi, Y., Ikehara, Y.
- Publisher
  Elsevier Chapter 592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Book] The Handbook of Proteolytic Enzymes (2^<nd> Edition) (分担) Chapter 592. Dipeptidyl-peptidase IV (A.J.Barrett, N.D.Rawrings and J.F.Woessner, eds.)2004
- Author(s)
  Y.Misumi, Y.Ikehara
- Publisher
  Elsevier/Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] The ectonucleotidases alkaline phosphatases and NTTDase 2 are associated with specific progenitor cell proliferations in the mouse embryonic, postnatal and adult neurogenic zones2007
- Author(s)
  Langer, D., Ikehara, Y., Takebayashi, H., Hawkes, R., Zimmermann, H.
- Journal Title
  
  Neuroscience (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity2007
- Author(s)
  Sohda, M., Misumi, Y., Yoshimura, S., Nakamura, N., Fusano, T., Ogata, S., Sakisaka, S., Ikehara, Y.
- Journal Title
  
  Traffic 8 (3)
  
  Pages: 270-284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Extracellular nucleotide signaling in adult neural stem cells : synergism with growth factor-mediated cellular proliferation2006
- Author(s)
  Mishra, S.K., Braun, N., Shukla, V., Fullgrabe, M., Schomerus, C., Gachet, C., Ikehara, Y., Robson, S.C., Zimmermann, H.
- Journal Title
  
  Development 133 (4)
  
  Pages: 675-684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Altered expression of alkaline phosphatase (ALP) in the liver of primary biliary cirrhosis (PBC) patients2006
- Author(s)
  Suzuki, N., Takeyama, Y., Kitamura, Y., Sohda, T., Watanabe, H., Ikehara, Y., Sakisaka, S.
- Journal Title
  
  Hepatoplogy Research 35 (1)
  
  Pages: 37-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Functional role played by the GPI-anchor glycan of CD48 in IL-18-induced IFN-γ production2005
- Author(s)
  Fukushima, K., Ikehara, Y., Yamashita, K.
- Journal Title
  
  J. Biol. Chem. 280(18)
  
  Pages: 18056-18062
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport2005
- Author(s)
  Sohda, M., Misumi, Y., Yoshimura, S., Nakamura, N., Fusano, T., Sakisaka, S., Ogata, S., Fujimoto, J., Kiyokawa, N., Ikehara, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338, (2)
  
  Pages: 1268-1274
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Functional role played by the GPI-anchored glycan of CD48 in IL-18-induced IFN-y production2005
- Author(s)
  Fukushima, K., Ikehara, Y., Yamashita, K.
- Journal Title
  
  Journal of Biological Chemistry 280 (18)
  
  Pages: 18056-18062
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Inhibitory effect of α_1-antitrypsin Pittsburgh-type mutant (α_1-PIM/R) on proinsulin processing in regulated secretory pathway of pancreatic β-cell line MIN62003
- Author(s)
  Ohkubo, K., Naito, Y., Fujiwara, T., Miyazaki, J., Ikehara, Y., Ono, J.
- Journal Title
  
  Endocr. J. 50(1)
  
  Pages: 9-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Identification and characterization of a novel acylated Golgi protein, GCP16 that interacts with GCP1702003
- Author(s)
  Ohta, E., Misumi, Y., Sohda, M., Fijiwara, T., Yano, A., Ikehara, Y.
- Journal Title
  
  Journal of Biological Chemistry 278(51)
  
  Pages: 51957-51967
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] A β-N-acetylglucosaminyl phosphate diester residue is attached to the GPI anchor of human placental alkaline phosphatase2003
- Author(s)
  Fukushima, K., Ikehara, Y., Kanai, M., Kochibe, N., Yamashita, K.
- Journal Title
  
  J. Biol. Chem. 278(38)
  
  Pages: 36296-36303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid2003
- Author(s)
  Fujiwara, T., Misumi, Y., Ikehara, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 301(4)
  
  Pages: 927-933
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Structural formation and regulation of the Golgi complex (Review)(in Japnanese)2003
- Author(s)
  Misumi, Y., Ikehara, Y.
- Journal Title
  
  Seikagaku 75(6)
  
  Pages: 479-486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K^+ channels2003
- Author(s)
  Nadal, M.S., Ozaita, A., de Miera, E.V., Ma, Y., Mo, W., Goldberg, E.M., Amarillo, Y., Misumi, Y., Ikehara, Y., Neubert, T.A., Rudy, Y.
- Journal Title
  
  Neuron 37(3)
  
  Pages: 449-461
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] ゴルジ体の形成とその制御2003
- Author(s)
  三角佳生, 池原征夫
- Journal Title
  
  生化学 75, 6
  
  Pages: 479-485
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570167

1. MISUMI Yoshio (10148877)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 松岡雄治 (70078773)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TAKAMI Noboru (80154904)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 森武貞 (60028496)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 谷内昭 (50045324)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 山下克子 (70030905)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 村田長芳 (60020765)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. NAKANO Akihiko (90142140)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KITO Makoto (60027183)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. FUJIWARA Toshiyuki (80190099)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. 山本博 (70099018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 黒木求 (10131822)

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13. 黒木政秀 (40122692)

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14. 大村恒雄 (80029933)

# of Collaborated Projects: 2 results

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15. 田代裕 (40077558)

# of Collaborated Projects: 2 results

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16. IKEZAWA Hiroh (40080163)

# of Collaborated Projects: 1 results

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17. TAKESUE Yoshiki (50023651)

# of Collaborated Projects: 1 results

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18. TOMITA Motowo (30102370)

# of Collaborated Projects: 1 results

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19. NAKASHIMA Izumi (40022826)

# of Collaborated Projects: 1 results

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20. KATO Keitaro (70037571)

# of Collaborated Projects: 1 results

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21. TSUBOI Shozo (70004554)

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22. OHKUBO Kumiko (80223759)

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23. SATO Ryuichiro (50187259)

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24. KOHNO Kenji (50142005)

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25. KIKUCHI Masakazu (10278492)

# of Collaborated Projects: 1 results

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26. HIROSE Shinichi (60248515)

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27. NAKAMURA Nobuhiro (50294955)

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28. SOHDA Miwa (20258528)

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29. OKA Kimimitsu (10122681)

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30. OGATA Shigenori (30131816)

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31. 白日高歩 (20038863)

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32. 荒川文子 (50212618)

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33. 三原勝芳 (40029963)

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34. 姫野勝 (50037602)

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35. 勝沼信彦 (50035375)

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36. 高野達哉 (40124995)

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37. 大西俊一 (00025272)

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38. 牧田章 (60004561)

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39. 鈴木旺 (50022504)

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40. 内貴正治 (10020752)

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41. 宮城妙子 (50006110)

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42. 永井克孝 (80072974)

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43. 橋本隆 (80009935)

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44. 久下理 (30177977)

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45. 宮田愛彦 (70209914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IKEHARA Yukio 池原 征夫

Research Projects

Research Products

Co-Researchers

Identification and characterization of factors required for the Golgi structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and characterization of proteins required for the Golgi structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms for vesicular transport and Golgi structure formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

糖脂質(GPI)転移酵素の同定と遺伝子クローニングPrincipal Investigator

Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Posttranslational Modifications of Proteins during Intracellular TransportPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Principal Investigator

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Research Institution

Principal Investigator

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Structural Features, Biosynthesis and Processing of Glycolipid-anchored ProteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

IKEHARA Yukio 池原征夫