IKEHARA Yukio 池原征夫

Researcher Number	70037612
External Links
Affiliation (based on the past Project Information) *help	2006: Daiichi University, Pharmaceutical Science, Professor, 薬学部, 教授 2003 – 2005: 福岡大学, 医学部, 教授 1987 – 2001: Fukuoka University School of Medicine, 医学部, 教授 1986: 福岡大, 医学部, 教授 1985: 福岡大学, 医, 教授
Review Section/Research Field	Principal Investigator General medical chemistry / Structural biochemistry / Cell biology / Biological Sciences Except Principal Investigator Cell biology / Structural biochemistry / 代謝生物化学 / 広領域
Keywords	Principal Investigator GCP16 / GCP60 / p115 / GCP170 / Giantin / 補体成分C3 / Golgi structural formation / アシル化 / COG複合体 / ゴルジ体 … More / 小胞輸送 / cDNAクロ-ニング / Dipeptidyl peptidase IV / アルカリホスファタ-ゼ / Furin / ハプトグロビン / 糖鎖構造 / プロセシング / プロ型前駆体 / COOH-terminal signal / Primary structure / carcinoembryonic antigen / alkaline phosphatase / 5'-nucleotidase / GPI-anchored proteins / GPI-anchor / 5′ーヌクレオチダーゼの一次構造 / 糖脂質アンカー / 5′ーヌクレオチダーゼ / 糖脂質結合型膜蛋白質 / 糖脂質アンカ- / 5´ーヌクレオチダ-ゼ / 糖脂質結合型蛋白質 / C末端シグナル / 一次構造 / 癌胎児性抗原 / 5′ーヌクレオチダ-ゼ / GPIーアンカ-型蛋白質 / 糖脂質(GPI)アンカ- / Fibrinogen sulfation / Fibrinogen / Compelement C3 / Haptoglobin / Precursor Processing / Plasma Protein Precursors / 蛋白質の硫酸化 / 血清蛋白質 / 初代培養ラット肝細胞 / 血清蛋白質の糖鎖構造 / フィブリノーゲンの硫酸化 / フィブリノーゲン / 補体C3 / 前駆体のプロセシング / 血清蛋白質の前駆体 / vesicle-tethering factor / COG complex / Golgi apparatus / organella / 局在化ドメイン / ゴルジ体形成因子 / 小胞繋留因子 / 構造形成 / オルガネラ / Golgi-localizing proteins / Gogi apparatus / ゴルジ膜結合様式 / p115ノックダウン / ゴルジ体局在タンパク質 / ゴルジ体管状構造形成 / ゴルジ体構造形成因子 / ゴルジ体局在蛋白質 / Golgi-associated proteins / Golgi targeting signal / Golgi structure formation / ER-Golgi transport / 小胞接着因子p115 / ゴルジ膜蛋白質 / 分泌阻害剤 / オルガネラ形成機構 / ゴルジ装置形成 / Golgin97 / GRASP65 / マトリックス蛋白質GM130 / Giantin(GCP372) / ゴルジ局在蛋白質 / ゴルジ装置形成機構 / ゴルジ膜局在タンパク質 / ゴルジ装置局在化シグナル / ゴルジ装置構造形成 / 小胞体-ゴルジ間輸送 / Enzyme defect / Alkaline phosphatase / GPI anchor / Complement C3 / Proalbumin / Proprotein processing / 補体C3前駆体 / 変換酵素インヒビタ- / 小胞体内蛋白質分解 / 活性中心 / アミノ酸置換 / ジペプチジルペプチダ-ゼIV / 細胞内プロセシング / 酵素欠損 / GPIアンカ- / プロアルブミン / プロ型前駆体変換酵素 / 弱塩基類 / 細胞内蛋白修飾 / 前駆体の変換 / キメラ蛋白質 / アフィニテイーリガンド / GPIシグナルペプチド / in vitro アッセイ / 糖脂質(GPI)転移酵素 / GPIアンカー型蛋白質 … More Except Principal Investigator CEA / 小胞体 / GPI-アンカー / 大腸癌 / 腫瘍マーカー / 癌特異性 / 腫瘍マ-カ- / NCA / GPI anchor / GPIアンカー / chaperone / protein degradation / quality control / endoplasmic reticulum / システインプロテアーゼ / シャペロン / タンパク質分解 / クオリティコントロール / Nucleus / Endosome / Endoplasmic reticulum / Peroxisame / Lysosome / Mitochondrion / Molecular recognition / Cell organelle / ゴルジ体 / リソソ-ム / 選別シグナル / エンドサイト-シス / 形質膜 / 分子認識 / 細胞オルガネラ / 核 / エンドソ-ム / ペルオキシソ-ム / リソゾ-ム / ミトコンドリア / 分子認隣 / 細胞オルがネラ / PNH / Hydrophobic Anchor / Phosphatidylinositol / Membranous Proteins / PI Anchor / PIアンカ- / 発作性夜間血色素尿症 / 疎水性アンカ- / ホスファチジルイノシト-ル / 膜蛋白質 / PI:アンカ- / 癌血清診断 / 癌マーカー / 癌糖鎖特異的モノクロン抗体 / 癌遺伝子導入糖鎖変化 / 糖転移酵素 / 糖蛋白質 / 糖脂質 / 細胞表面糖鎖 / 大腸粘膜crypt / エンドサイトーシス / エキソサイトーシス / 蛋白質輸送 / リソソーム / 小胞輸送 / 蛋白質膜透過 / ゴルジ装置 / 蛋白質選別輸送 / 正常大腸粘膜 / carcinoembryonic antigen(CEA) / 細胞接着活性 / BGP / GPI結合型蛋白質 / モノクロ-ナル抗体 / 抗原決定基 / GPI型膜結合 / 大腸粘膜上皮細胞 / 正常大腸粘膜のCEA産生 / 癌特異的抗原性 / 正常糞便抗原 / glycolipid anchor / 癌胎児性抗原 Less

Identification and characterization of factors required for the Golgi structurePrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Daiichi University
  Fukuoka University
Identification and characterization of proteins required for the Golgi structurePrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Fukuoka University
Molecular mechanisms for vesicular transport and Golgi structure formationPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka University
Study on the topology of the GPI anchor assembly
- Principal Investigator
  
  HIROSE Shinichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Fukuoka University
糖脂質(GPI)転移酵素の同定と遺伝子クローニングPrincipal Investigator
- Principal Investigator
  
  池原征夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fukuoka University
Studies of quality control of proteins in the endoplasmic reticulum.
- Principal Investigator
  
  KITO Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  KYOTO UNIVERSITY
CEAの癌特異性の解明:大腸粘膜におけるその産生動態の生理と病理
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
CEAの癌特異性の解明:大腸粘膜におけるその産生動態の生理と病理
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
小胞体経路の蛋白質選別輸送の分子機構
- Principal Investigator
  
  大村恒雄
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
CEAの癌特異性の解明:大腸粘膜におけるその産生動態の生理と病理
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
粘膜上皮細胞の分化並びに癌化に伴うCEA及び関連抗原の産生動態の変化
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
Posttranslational Modifications of Proteins during Intracellular TransportPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukuoka University
癌胎児性抗原(CEA)の癌特異性の本態の解明
- Principal Investigator
  
  松岡雄治
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fukuoka University
The Biological Significance of PI as the Hydrophobic Anchor for Membranous Proteins
- Principal Investigator
  
  IKEZAWA Hiroh
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Nagoya City University
Molecular Recognition Involved in the Formation of Cell Organelles.
- Principal Investigator
  
  KATO Keitaro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  代謝生物化学
- Research Institution
  Kyushu University
Structural Features, Biosynthesis and Processing of Glycolipid-anchored ProteinsPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukuoka University
癌の細胞膜糖鎖変化の機構と応用に関する研究
- Principal Investigator
  
  牧田章
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
Biosynthesis and Intracellular Modifications of Plasma ProteinsPrincipal Investigator
- Principal Investigator
  
  IKEHARA Yukio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukuoka University
分泌阻害剤の応用による分泌蛋白質プロセシングの解析Principal Investigator
- Principal Investigator
  
  池原征夫
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Fukuoka University

All 2007 2006 2005 2004 2003

All Journal Article Book

[Book] The Handbook of Proteolytic Enymes (2^<nd> edition) (A.J.Barrett et al., eds.) (Dipeptidyl-peptidases A and B)2004
- Author(s)
  Misumi, Y., Ikehara, Y.
- Publisher
  Elsevier Chapter 593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Book] The Handbook of Proteolytic Enzymes (2^<nd> Edition) (分担) Chapter 593. Dipeptidyl-peptidases A and B(A.J.Barrett, N.D.Rawrings and J.F.Woessner, eds.)2004
- Author(s)
  Y.Misumi, Y.Ikehara
- Publisher
  Elsevier/Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Book] The Handbook of Proteolytic Enymes (2^<nd> edition) (A.J.Barrett et al., eds.) (Dipeptidyl-peptidase IV)2004
- Author(s)
  Misumi, Y., Ikehara, Y.
- Publisher
  Elsevier Chapter 592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Book] The Handbook of Proteolytic Enzymes (2^<nd> Edition) (分担) Chapter 592. Dipeptidyl-peptidase IV (A.J.Barrett, N.D.Rawrings and J.F.Woessner, eds.)2004
- Author(s)
  Y.Misumi, Y.Ikehara
- Publisher
  Elsevier/Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] The ectonucleotidases alkaline phosphatases and NTTDase 2 are associated with specific progenitor cell proliferations in the mouse embryonic, postnatal and adult neurogenic zones2007
- Author(s)
  Langer, D., Ikehara, Y., Takebayashi, H., Hawkes, R., Zimmermann, H.
- Journal Title
  
  Neuroscience (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity2007
- Author(s)
  Sohda, M., Misumi, Y., Yoshimura, S., Nakamura, N., Fusano, T., Ogata, S., Sakisaka, S., Ikehara, Y.
- Journal Title
  
  Traffic 8 (3)
  
  Pages: 270-284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Extracellular nucleotide signaling in adult neural stem cells : synergism with growth factor-mediated cellular proliferation2006
- Author(s)
  Mishra, S.K., Braun, N., Shukla, V., Fullgrabe, M., Schomerus, C., Gachet, C., Ikehara, Y., Robson, S.C., Zimmermann, H.
- Journal Title
  
  Development 133 (4)
  
  Pages: 675-684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Altered expression of alkaline phosphatase (ALP) in the liver of primary biliary cirrhosis (PBC) patients2006
- Author(s)
  Suzuki, N., Takeyama, Y., Kitamura, Y., Sohda, T., Watanabe, H., Ikehara, Y., Sakisaka, S.
- Journal Title
  
  Hepatoplogy Research 35 (1)
  
  Pages: 37-44
- NAID
  10020329648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Functional role played by the GPI-anchor glycan of CD48 in IL-18-induced IFN-γ production2005
- Author(s)
  Fukushima, K., Ikehara, Y., Yamashita, K.
- Journal Title
  
  J. Biol. Chem. 280(18)
  
  Pages: 18056-18062
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport2005
- Author(s)
  Sohda, M., Misumi, Y., Yoshimura, S., Nakamura, N., Fusano, T., Sakisaka, S., Ogata, S., Fujimoto, J., Kiyokawa, N., Ikehara, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338, (2)
  
  Pages: 1268-1274
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Functional role played by the GPI-anchored glycan of CD48 in IL-18-induced IFN-y production2005
- Author(s)
  Fukushima, K., Ikehara, Y., Yamashita, K.
- Journal Title
  
  Journal of Biological Chemistry 280 (18)
  
  Pages: 18056-18062
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570100
[Journal Article] Inhibitory effect of α_1-antitrypsin Pittsburgh-type mutant (α_1-PIM/R) on proinsulin processing in regulated secretory pathway of pancreatic β-cell line MIN62003
- Author(s)
  Ohkubo, K., Naito, Y., Fujiwara, T., Miyazaki, J., Ikehara, Y., Ono, J.
- Journal Title
  
  Endocr. J. 50(1)
  
  Pages: 9-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Identification and characterization of a novel acylated Golgi protein, GCP16 that interacts with GCP1702003
- Author(s)
  Ohta, E., Misumi, Y., Sohda, M., Fijiwara, T., Yano, A., Ikehara, Y.
- Journal Title
  
  Journal of Biological Chemistry 278(51)
  
  Pages: 51957-51967
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] A β-N-acetylglucosaminyl phosphate diester residue is attached to the GPI anchor of human placental alkaline phosphatase2003
- Author(s)
  Fukushima, K., Ikehara, Y., Kanai, M., Kochibe, N., Yamashita, K.
- Journal Title
  
  J. Biol. Chem. 278(38)
  
  Pages: 36296-36303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid2003
- Author(s)
  Fujiwara, T., Misumi, Y., Ikehara, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 301(4)
  
  Pages: 927-933
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] Structural formation and regulation of the Golgi complex (Review)(in Japnanese)2003
- Author(s)
  Misumi, Y., Ikehara, Y.
- Journal Title
  
  Seikagaku 75(6)
  
  Pages: 479-486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K^+ channels2003
- Author(s)
  Nadal, M.S., Ozaita, A., de Miera, E.V., Ma, Y., Mo, W., Goldberg, E.M., Amarillo, Y., Misumi, Y., Ikehara, Y., Neubert, T.A., Rudy, Y.
- Journal Title
  
  Neuron 37(3)
  
  Pages: 449-461
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570167
[Journal Article] ゴルジ体の形成とその制御2003
- Author(s)
  三角佳生, 池原征夫
- Journal Title
  
  生化学 75, 6
  
  Pages: 479-485
- NAID
  10011214020
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570167

1. MISUMI Yoshio (10148877)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 松岡雄治 (70078773)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TAKAMI Noboru (80154904)

# of Collaborated Projects: 3 results

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4. 森武貞 (60028496)

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5. 谷内昭 (50045324)

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6. 山下克子 (70030905)

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7. 村田長芳 (60020765)

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8. NAKANO Akihiko (90142140)

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9. KITO Makoto (60027183)

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10. FUJIWARA Toshiyuki (80190099)

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11. 山本博 (70099018)

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12. 黒木求 (10131822)

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13. 黒木政秀 (40122692)

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14. 大村恒雄 (80029933)

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15. 田代裕 (40077558)

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16. IKEZAWA Hiroh (40080163)

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17. TAKESUE Yoshiki (50023651)

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18. TOMITA Motowo (30102370)

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19. NAKASHIMA Izumi (40022826)

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20. KATO Keitaro (70037571)

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21. TSUBOI Shozo (70004554)

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22. OHKUBO Kumiko (80223759)

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23. SATO Ryuichiro (50187259)

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24. KOHNO Kenji (50142005)

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25. KIKUCHI Masakazu (10278492)

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26. HIROSE Shinichi (60248515)

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27. NAKAMURA Nobuhiro (50294955)

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28. SOHDA Miwa (20258528)

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29. OKA Kimimitsu (10122681)

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30. OGATA Shigenori (30131816)

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31. 白日高歩 (20038863)

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32. 荒川文子 (50212618)

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33. 三原勝芳 (40029963)

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34. 姫野勝 (50037602)

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35. 勝沼信彦 (50035375)

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36. 高野達哉 (40124995)

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37. 大西俊一 (00025272)

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38. 牧田章 (60004561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 鈴木旺 (50022504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 内貴正治 (10020752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 宮城妙子 (50006110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 永井克孝 (80072974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 橋本隆 (80009935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 久下理 (30177977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 宮田愛彦 (70209914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IKEHARA Yukio 池原 征夫

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Identification and characterization of factors required for the Golgi structurePrincipal Investigator

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Identification and characterization of proteins required for the Golgi structurePrincipal Investigator

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Molecular mechanisms for vesicular transport and Golgi structure formationPrincipal Investigator

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糖脂質(GPI)転移酵素の同定と遺伝子クローニングPrincipal Investigator

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Posttranslational Modifications of Proteins during Intracellular TransportPrincipal Investigator

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Structural Features, Biosynthesis and Processing of Glycolipid-anchored ProteinsPrincipal Investigator

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IKEHARA Yukio 池原征夫