NAKASHIMA Izumi 中島泉

Researcher Number	40022826
Affiliation (based on the past Project Information) *help	2006: Chubu University, Life Health Sciences, Professor 2005: 中部大学, 生命健康科学研究所, 教授 2002 – 2003: 名古屋大学, 大学院・医学系研究科, 教授 2001: Graduate School of Medicine, Nagoya University, Professor, 大学院・医学研究科, 教授 1993 – 2000: 名古屋大学, 医学部, 教授 1989 – 1991: 名古屋大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Dermatology / 広領域 Except Principal Investigator Biological Sciences / General surgery / 広領域 / Pathological medical chemistry / Experimental pathology / Immunology / Risk sciences of radiation/Chemicals / Immunology
Keywords	Principal Investigator トランスジェニックマウス / RET / がん遺伝子 / 酸化ストレス / メラノーマ / 紫外線 / メラノ-マ / 腫瘍免疫 / システイン残基 / チロシンキナーゼ … More / 国際情報交換 / アメリカ / 細胞傷害性Tリンパ球 / 十全大補湯 / グリチルリチン / RETがん遺伝子 / MKK6- / がん発生 / 免疫反応 / retがん遺伝子 / メラノ-シス / プレ-Bリンホマ / 前がん / 発がん制御 / がん遺伝子ret / TNFレセプター / 免疫遺伝子治療 / 重金属イオン / 塩化第2水銀 / 一酸化窒素 / シグナル伝達 / スルフヒドリル基 / Srcキナーゼ / チロシンリン酸化 / 2量体 / 酸化還元 / S-S結合 / メラニン産生 / c-Kit / Wv / Wvマウス / 抗c-Kit抗体 / 重金属ストレス / 免疫促進 / 腫瘍増殖抑制 / 漢方 / クルクミン / RET-トランスジェニックマウス / 悪性黒色腫 / メラノサイト系腫瘍 / 抗酸化物質 / Rfp-Ret / スーパー活性化 / 悪性転化 / RET oncogene / RET-transgenic mice / ultraviolet / malignant / malignant melanoma / melanocytic tumors / oxidative stress / anti-oxidants / チロシンナーゼ / レドックス / T細胞 / ラフト / アポトーシス / -マウス / ネガテイブセレクション / Tyrosine kinase / redox / T-lymphocyte / reft / apoptosis / -mouse / negative selection … More Except Principal Investigator トランスジェニックマウス / メラノーマ / 制御性T細胞 / CD122 / 異種移植 / がん抗原 / キラーT細胞 / サイトカイン / CD8 / 補体制御因子 / 遺伝子操作 / Complement regulatory factor / 異種抗原 / トランスジェニックブタ / トランスジェニック動物 / MMP / TIMP / チロシンキナーゼ / RET / EAE / CXCR3 / MHC結合ペプチド / CTL / がん免疫 / ドレランス / NKT細胞 / IL-12 / 養子免疫療法 / トレランス / 免疫寛容 / MHCペプチド / T細胞エピトープ / 補助シグナル / TIL / T細胞レパトア / クラスIMHC / ペプチドモチーフ / Retがん遺伝子 / 発がん感受性 / 遺伝子型解析 / Retトランスジェニックマウス / 遺伝子リンケージスタディ / 十全大補湯 / 細胞障害性T細胞 / 腫瘍発生 / T細胞サブセット / 試験管内培養系 / ナイーブT細胞 / 細胞表面マーカー / CD8陽性 / IL-2受容体 / インターフェロン-γ / MHCクラスI / T細胞受容体 / インターロイキン-10 / インターフェロン(IFN)-γ / インターロイキン(IL)-10 / PI:アンカ- / 膜蛋白質 / ホスファチジルイノシト-ル / 疎水性アンカ- / 発作性夜間血色素尿症 / PIアンカ- / PI Anchor / Membranous Proteins / Phosphatidylinositol / Hydrophobic Anchor / PNH / 複合糖質 / 糖鎖構造 / 糖鎖の多様性 / 糖鎖と病態 / モノクロ-ナル抗体 / 糖鎖抗原 / Glycocojugates, / Oligosaccharide structure / Polymorphism of oligosac-charides / 抗体産生 / 超急性拒絶反応 / gene engineering / marzinal zone / Xenotransplantation / Gene Engineering / Xenoantibody production / Hyperacute rejection / 補体制御因子遺伝子 / Xenotransplantaion / Transgenic pig / Xenoantigen / Gene engineering / 補体不活化因子 / ガラクトシルトランスフェラーゼ / フコシルトランスフェラーゼ / 遺伝子制御 / ノックアウト動物 / α1.3GT / α1.2FT / Transplantation, Heterologous / Animals, Transgenic / Complement Inactivators / Antigens, Heterophile / Galactosylransferases / Fucosyltransferases / 癌転移 / RET遺伝子 / 悪性黒色腫 / 甲状腺髄様癌 / MEN2A / ret遺伝子 / MMP-9 / transgenic mouse / metastasis / RET gene / medullary thyroid carcinoma / malignant melanoma / 静止期T細胞 / リンパ節由来ストロマ細胞 / 生存因子 / 遺伝子クローニング / 機能的アッセイ / ノックアウトマウス / ケモカイン / T細胞生存因子 / 遺伝子ターゲティング / リンパ節ストロマ細胞 / cDNAクローニング / Resting T cells / Lymph node-derived stromal cells / Survival factor / Cytokine / Gene cloning / Functional assay / Gene-targeted mice / Chemokine / ヒ素 / スーパーオキサイドディスミュターゼ / 癌 / スーパー活性化 / 発癌機構 / アミノ酸 / スーパーオキサイド / 癌遺伝子産物 / ERK / ゼラチン分解酵素 / arsenic / tyrosine kinase / superoxide dismutase / cancer / superactivation / 免疫制御 / CD8^+T細胞 / Immune regulation / Regulatory T cells / CD8^+ T cells Less

CD8^+CD122^+制御性T細胞による免疫制御機構の解明
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Clarification of the role of CD8^+CD122^+ regulatory T cells in vivo and development of their clinical applications
- Principal Investigator
  
  SUZUKI Haruhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Nagoya University
Mechanism of a arsenic-mediated cancer development
- Principal Investigator
  
  KATO Masashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Chubu University
メラノーマ自然発症マウスを用いたCTL免疫誘導促進性抗がん物質の新規探索法の開発Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
メラノーマ自然発症トランスジェニックモデルを用いたCTL誘導性抗がん物質の探索Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Study on redox-linked regulatory mechanism of intracellular signal transduction for differentiation and death of T lymphocytesPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Izumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Nagoya University
制御性T細胞の発がん制御への関わりとその機構に関する研究
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
がん遺伝子産物チロシンキナーゼの酸化的構造修飾による高度活性化の機序と意義Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Retがん遺伝子誘発メラノーマの発がん感受性を決定する遺伝子の検索
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
増殖因子受容体がん遺伝子産物の酸化的構造修飾による活性化の機序と意義Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
トランスジェニックマウスを用いたc-Kit分子を標的とした悪性黒色腫治療Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Identification of factors sftpporting the survival of mature T lymphocytes
- Principal Investigator
  
  SUZUKI Haruhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Nagoya University
Analysis of the mechanism of ultraviolet irradiation-mediated induction skin malignant melanomaPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Izumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagoya University
Retがん遺伝子誘発メラノーマの発がん感受性を決定する遺伝子要因
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
がん免疫寛容のメカニズムとその制御
- Principal Investigator
  
  谷口克
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
SH基修飾性化学物質を探索子とするストレスシグナル伝達カスケードの解析Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Analysis of molecular mechanisms of cancer metastasis using transgenic mice
- Principal Investigator
  
  TAKAHASHI Masahide
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya University
Research on xenotransplantation using genetic engineering
- Principal Investigator
  
  TAKAGI Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
Establishment of Transgenic Pig for Organ Xenotransplantation
- Principal Investigator
  
  TAKAGI Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
がん抗原分子と免疫認識
- Principal Investigator
  
  谷口克
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Chiba University
トランスジェニックマウス発がん個体において有効な免疫遺伝子治療法開発のための基礎的研究Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
Study of Xenotransplatation Using Gene Engineering Technique
- Principal Investigator
  
  TAKAGI Hiroshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
がん遺伝子トランスジェニックマウス前がん段階の免疫調節による発がんの制御Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
メラノ-マ好発系トランスジェニックマウスにおけるがん発生初期段階の免疫反応の解析Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
The Biological Significance of PI as the Hydrophobic Anchor for Membranous Proteins
- Principal Investigator
  
  IKEZAWA Hiroh
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Nagoya City University
Polymorphism of oligosaccharide structure in glycoconjugaates
- Principal Investigator
  
  TAKAHASHI Noriko
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya City University College of Nursing

All 2006 2005

All Journal Article Book

[Book] 免疫実験法ハンドブック2006
- Author(s)
  中島泉 (編)
- Total Pages
  358
- Publisher
  名古屋大学出版会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Book] 免疫学実験法ハンドブック2006
- Author(s)
  中島, 加藤ら[中島泉編]
- Total Pages
  358
- Publisher
  名古屋大学出版会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310037
[Book] Handbook of Experimental Immunology2006
- Author(s)
  Izumi Nakashima (editor)
- Total Pages
  358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Book] Prog Protein Res2005
- Author(s)
  Nakashima I, Kato M (5/6), et al.
- Publisher
  MXXCW motif as a potential initiator of protein tyrosine kinases.(印刷中)
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I
- Journal Title
  
  FEBS Letter 580
  
  Pages: 839-843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I.
- Journal Title
  
  FEBS Letter 580(3)
  
  Pages: 839-843
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H. Isobe K, Nakashima I
- Journal Title
  
  FEBS Letter 580
  
  Pages: 839-843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] Redox control of catalytic activities of membrane-associated protein.2005
- Author(s)
  Nakashima I, Kato M (5/6), et al.
- Journal Title
  
  Arch Biochem Biophys 434
  
  Pages: 3-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] Redox control of catalytic activities of membrane-associated protein2005
- Author(s)
  Nakashima I, Kato M (6人中5番目), et al.
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 434 Pages: 3-10
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] Redox control of catalytic activities of membrane-associated protein tyrosine kinases.2005
- Author(s)
  Nakashima I
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 434 Pages: 3-10
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] Redox control of catalytic activities of membrane-associated protein2005
- Author(s)
  Nakashima I, Kato M (5/6), et al.
- Journal Title
  
  Arch Biochem Biophys 434
  
  Pages: 3-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310037

1. SUZUKI Haruhiko (90283431)

# of Collaborated Projects: 14 results

# of Collaborated Products: 3 results
2. KATO Masashi (10281073)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
3. ISOBE K (20151441)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. TAKEDA Kozue (80345884)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
5. OKADA Hidechika (30160683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TAKAGI Hiroshi (70154755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HAYASHI S (30218573)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 谷口克 (80110310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 佐藤昇志 (50158937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 古川鋼一 (80211530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 栗林景容 (10064578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. IKEZAWA Hiroh (40080163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKESUE Yoshiki (50023651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TOMITA Motowo (30102370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IKEHARA Yukio (70037612)

# of Collaborated Projects: 1 results

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16. KITO Makoto (60027183)

# of Collaborated Projects: 1 results

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17. TAKAHASHI Noriko (90079989)

# of Collaborated Projects: 1 results

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18. KANNAGI Reiji (80161389)

# of Collaborated Projects: 1 results

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19. ISHIHARA Hideko (90080192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HAYASHI Kyozo (00029935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ARATA Yoji (40011499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOKOYAMA Itsuo (60240206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KITO Junzo (60022802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MURAMATSU Takashi (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKAHASHI Masahide (40183446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. IWASHITA Toshihide (00283432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KAMBAYASHI Yasuhiro (20345630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. OGINO Keiki (70204104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HAYAKAWA Akemi (70412377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 岩本隆司 (60223426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 長瀬文彦 (10109340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 江浦正郎 (60193984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 西村孝司 (30143001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 藤原大美 (70116094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 奥村康 (50009700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 西村泰治 (10156119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 石川哮 (00009143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 高橋利忠 (00124529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 渡辺武 (40028684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 浅井直也 (80273233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 小林章二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. KOBAYASHI S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKASHIMA Izumi 中島 泉

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メラノーマ自然発症マウスを用いたCTL免疫誘導促進性抗がん物質の新規探索法の開発Principal Investigator

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メラノーマ自然発症トランスジェニックモデルを用いたCTL誘導性抗がん物質の探索Principal Investigator

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Study on redox-linked regulatory mechanism of intracellular signal transduction for differentiation and death of T lymphocytesPrincipal Investigator

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がん遺伝子産物チロシンキナーゼの酸化的構造修飾による高度活性化の機序と意義Principal Investigator

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増殖因子受容体がん遺伝子産物の酸化的構造修飾による活性化の機序と意義Principal Investigator

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トランスジェニックマウスを用いたc-Kit分子を標的とした悪性黒色腫治療Principal Investigator

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Analysis of the mechanism of ultraviolet irradiation-mediated induction skin malignant melanomaPrincipal Investigator

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NAKASHIMA Izumi 中島泉