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SHIGEMATSU Naoyuki  茂松 直之

ORCIDConnect your ORCID iD *help
Researcher Number 30178868
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2016 – 2020: 慶應義塾大学, 医学部(信濃町), 教授
2009 – 2015: Keio University, 医学部, 教授
2002: Keio Univ., School of Medicine, Associate Professor, 医学部, 講師
2001: Radiology, School of Medicine, Keio University Lecture, 医学部, 助手
2000: School of Medicine, KEIO University Associate Professor, 医学部, 専任講師 … More
2000: Keio University, School of Medicine, Assistant Professor, 医学部, 講師
1999 – 2000: 慶應義塾大学, 医学部, 専任講師
1999: 慶応義塾大学, 医学部, 講師
1998 – 1999: 慶應義塾大学, 医学部, 助手
1996 – 1997: 慶應義塾大学, 医学部, 専任講師
1992 – 1995: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Radiation science / Radiation science / Basic Section 52040:Radiological sciences-related
Except Principal Investigator
Radiation science / General surgery
Keywords
Principal Investigator
放射線治療 / 放射線照射 / 放射線増感剤 / 放射線生物学 / Radiotherapy / アポトーシス / LET / 遺伝子突然変異 / 胃癌 / 増感剤 … More / 放射線抵抗性 / ドラッグリポジショニング / クロロキン / 膵臓癌 / オートファジー / 膵癌 / メトフォルミン / Late-radiation toxicity / Total body irradiation / Chromosomal aberration / 細胞周期 / 晩期放射線障害 / 全身照射 / 染色体異常 / Apoptosis / Mutation / Heavy Ion Beam / RBE / 重粒子線 / PI3K/Akt/mTOR経路 / 増感遺伝子解析 / 染色体解析 / 増感効果 / ラジカル / 低酸素細胞 … More
Except Principal Investigator
放射線療法 / 放射線感受性 / chemotherapy / artificial oxygen carrier / 人工酸素運搬体 / LET / Lymphocyte / Radiotherapy / リンパ球 / 放射線治療 / radiation / Ly-80 / tumor / rat / 補助科学療法 / 動脈内注入 / 腫瘍循環 / 腫瘍内酸素分圧 / LK-80 / 抗癌剤 / LY-80 / 腫瘍 / ラット / Calicurein A / Radiosensitivity / Transformation / FISH method / カリクレイン / カリクレインA / 染色体変異 / FISH法 / increment of sensitivity / drug sensitivity test / oxygenations of tumors / 腫瘍細胞の酸素化 / 化学療法 / 感受性の増強 / 抗癌剤感受性試験 / 腫瘍の酸素化 / Mutation / Neon beams / Carbon beamd / 培養細胞 / 重粒子線 / hprt / 突然変異 / ネオン粒子線 / 炭素粒子線 / Predictive assay / Fibroblast / Late radiation injury / 初代培養細胞 / 光学的生存率測定 / 耐用線量 / 慢性放射線障害 / 放射線慢性障害 / 障害予測因子 / 線維芽細胞 / 晩期放射線障害 Less
  • Research Projects

    (11 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (32 People)
  •  Development of new radiation sensitization therapy by drug repositioning of chloroquinePrincipal Investigator

    • Principal Investigator
      SHIGEMATSU Naoyuki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Keio University
  •  Development of tumor-specific innovative drug Metformin for gastric cancer cell linesPrincipal Investigator

    • Principal Investigator
      Shigematsu Naoyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Keio University
  •  Radiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitorsPrincipal Investigator

    • Principal Investigator
      SHIGEMATSU Naoyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Keio University
  •  Administration of a hypoxic cell sensitizer, 6-FP, enhance of radiation-induced apoptosis in human carcinomaPrincipal Investigator

    • Principal Investigator
      SHIGEMATSU Naoyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Keio University
  •  Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers

    • Principal Investigator
      KOBAYASHI Koichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      KEIO UNIVERSITY
  •  Application of Modified FISH to Analyze Tumor Cell Radioresistance and Development of Its Clinical Application

    • Principal Investigator
      ITO Hisao
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Chiba University
  •  PREDICTIVE SCREENING ASSAY FOR RADIATION INDUCED DAMAGES CAUSED BY CLINICAL RADIOTHERAPYPrincipal Investigator

    • Principal Investigator
      SHIGEMATSU Naoyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      KEIO University
  •  Tumor oxygenation to in crease sensitivity to anti-cancerous drug by using artificial oxygen carrier

    • Principal Investigator
      KOBAYASHI Koichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      General surgery
    • Research Institution
      Keio University
  •  EVALUATION OF APOPTOSIS RELATED GENE AND MUTATION INDUCTION FATER IRRADIATION.Principal Investigator

    • Principal Investigator
      SHIGEMATSU Naoyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      KEIO University
  •  Analysis of Redioresistant Tumor by Heavy Particle Irradiation

    • Principal Investigator
      ITO Hisao
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Keio University
  •  Predictive assay for late radiation injury with fibroblast and lymphocyte

    • Principal Investigator
      ITO Hisao
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      School of Medicine, Keio University

All 2020 2019 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Efficacy evaluation of 2D, 3D U-Net semantic segmentation and atlas-based segmentation of normal lungs excluding the trachea and main bronchi.2020

    • Author(s)
      Nemoto T, Futakami N, Yagi M, Kumabe A, Takeda A, Kunieda E, Shigematsu N.
    • Journal Title

      J Radiat Res

      Volume: 61(2) Issue: 2 Pages: 257-264

    • DOI

      10.1093/jrr/rrz086

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07771, KAKENHI-PROJECT-17K10493, KAKENHI-PROJECT-20K08034
  • [Journal Article] 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche2020

    • Author(s)
      Koike Naoyoshi、Kota Ryuichi、Naito Yoshiko、Hayakawa Noriyo、Matsuura Tomomi、Hishiki Takako、Onishi Nobuyuki、Fukada Junichi、Suematsu Makoto、Shigematsu Naoyuki、Saya Hideyuki、Sampetrean Oltea
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 450-462

    • DOI

      10.1038/s42003-020-01165-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07671, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-20K16801, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07771
  • [Journal Article] Pleural contact decreases survival in clinical T1N0M0 lung cancer patients undergoing SBRT.2019

    • Author(s)
      Eriguchi T, Takeda A, Tsurugai Y, Sanuki N, Kibe Y, Hara Y, Kaneko T, Taguri M, Shigematsu N.
    • Journal Title

      Radiother Oncol

      Volume: 134 Pages: 191-198

    • DOI

      10.1016/j.radonc.2019.02.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07771, KAKENHI-PROJECT-16K10403
  • [Journal Article] A Highly Advanced Gastric Cancer Maintaining a Clinical Complete Response after Chemoradiotherapy Comprising S-1 and Cisplatin2018

    • Author(s)
      Yura Masahiro、Takahashi Tsunehiro、Fukuda Kazumasa、Nakamura Rieko、Wada Norihito、Fukada Junichi、Kawakubo Hirofumi、Takeuchi Hiroya、Shigematsu Naoyuki、Kitagawa Yuko
    • Journal Title

      Case Reports in Gastroenterology

      Volume: 12 Issue: 3 Pages: 578-585

    • DOI

      10.1159/000492206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10492, KAKENHI-PROJECT-18K07771
  • [Journal Article] Prostate-specific antigen nadir within 12 months as an early surrogate marker of biochemical failure and distant metastasis after low-dose-rate brachytherapy or external beam radiotherapy for localized prostate cancer.2018

    • Author(s)
      Nishimura S, Ohashi T, Momma T, Sakayori M, Eriguchi T, Tanaka T, Yamashita S, Kosaka T, Oya M, Shigematsu N
    • Journal Title

      Cancer Med

      Volume: 7 Issue: 5 Pages: 1794-1801

    • DOI

      10.1002/cam4.1443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07771
  • [Journal Article] Long-term results of concurrent chemoradiotherapy with daily-low-dose continuous infusion of 5-fluorouracil and cisplatin (LDFP) for Stage I-II esophageal carcinoma2017

    • Author(s)
      Kumabe A、Fukada J、Kota R、Koike N、Shiraishi Y、Seki S、Yoshida K、Kitagawa Y、Shigematsu N
    • Journal Title

      Diseases of the Esophagus

      Volume: 31 Issue: 4 Pages: 1-8

    • DOI

      10.1093/dote/dox138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Journal Article] Long-term Clinical Results of Concurrent Chemoradiotherapy for Patients with Cervical Esophageal Squamous Cell Carcinoma.2017

    • Author(s)
      Atsuhiro Kumabe, Sadatomo Zenda, Atsushi Motegi, Masakatsu Onozawa, Naoki Nakamura, Takashi Kojima, Hiroyuki Daiko, Naoyuki Shigematsu, and Tetsuo Akimoto
    • Journal Title

      Anticancer Res

      Volume: 37(9) Issue: 9 Pages: 5039-5044

    • DOI

      10.21873/anticanres.11919

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10411, KAKENHI-PROJECT-15K10008
  • [Journal Article] Impact of MRI-based postimplant dosimetric assessment in prostate brachytherapy using contrast-enhanced T1-weighted images2012

    • Author(s)
      Ohashi T., Momma T., Yamashita S., Nagatusma K., Kanai K., Kitagawa K., Takahashi S., Hanada T., Yorozu A., Shigematsu N
    • Journal Title

      Brachytherapy

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591619
  • [Journal Article] Clinical evidence of particle beam therapy2012

    • Author(s)
      Shigematsu N, Shiraishi Y., Seki S., Fukada J., Ohashi T
    • Journal Title

      Int J Clin Oncol

      Volume: 17(2) Pages: 75-78

    • NAID

      10030626272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591619
  • [Presentation] 機械学習による胸部放射線照射後の予後予測因子と有害事象発症予測因子の探索2020

    • Author(s)
      深田淳一、深田恭平、小池直義、公田龍一、茂松直之
    • Organizer
      第58回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07771
  • [Presentation] 放射線照射後のマウス心臓の形態学的・病理学的検討2019

    • Author(s)
      小池直義、深田淳一、公田龍一、伊藤章吾、湯浅慎介、茂松直之
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Data Source
      KAKENHI-PROJECT-18K07771
  • [Presentation] マウス放射線肺臓炎モデルにおける病理学的検討2019

    • Author(s)
      公田龍一、小池直義、深田淳一、茂松直之
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Data Source
      KAKENHI-PROJECT-18K07771
  • [Presentation] ステージI-II期食道癌に対する化学放射線療法2017

    • Author(s)
      外山弘文、深田淳一、隈部篤寛、公田龍一、小池直義、白石悠、北川雄光、茂松直之
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] Pleural and pericardial effusion after chemoradiotherapy in esophageal cancer patients. A predictive modeling using mean pericardial irradiated dose2016

    • Author(s)
      J. Fukada, T. Abe, A. Kumabe, H. Takaishi, Y. Kitagawa,N. Shigematsu
    • Organizer
      57th Annual Meeting of American Society for Therapeutic Radiology and Oncology
    • Place of Presentation
      ボストン(アメリカ合衆国)
    • Year and Date
      2016-09-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] Chromosomal Aberrations in Normal and AT Cells Exposed to High Dose of Low-dose-rate Irradiation2015

    • Author(s)
      Kawata T, Liu C, Fukada J, Kota R, Shigematsu N
    • Organizer
      International congress of Radiation Research
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] 食道癌化学放射線治療後の心嚢水・胸水貯留-平均心嚢照射線量を用いた予測モデル-2015

    • Author(s)
      深田淳一,阿部貴行,隈部篤寛,高石官均,北川雄光,茂松直之
    • Organizer
      第53回癌治療学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-29
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] PI3K/AKT/mTOR inhibitors enhance cytotoxic effect in combination with radiotherapy in gastric cancer cell lines2015

    • Author(s)
      深田淳一, 公田龍一, 三島眞代, 川田哲也, 茂松直之
    • Organizer
      日本放射線腫瘍学会第28回学術大会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] Cytogenetic Effects of Radiation and Caffeine on Normal Human Fibroblast and Ataxia Telangiectasia Heterozygous Fibroblast Cells2015

    • Author(s)
      Shigematsu N, Fukada J, Kota R, Shiraishi Y, Kawata T
    • Organizer
      International congress of Radiation Research
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] adiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitors2015

    • Author(s)
      Fukada J, Kota R, Mishima M, Kawata T, Shigematsu N
    • Organizer
      International congress of Radiation Research
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10008
  • [Presentation] Symptomatic pericardial effusion after chemoradiation therapy for esophageal cancer: A historical comparison.2013

    • Author(s)
      Fukada J, Shigematsu N, Takeuchi H, Shiraishi Y, Hanada T, Ohashi T, Kota R, Kumabe A, Sutani S, Kitagawa Y.
    • Organizer
      55th Annual Meeting of American Society for Therapeutic Radiology and Oncology
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-24591850
  • [Presentation] Inter- and intrafraction gastric motion study –Impact of breathing and stomach filling2012

    • Author(s)
      J. Fukada, N. Shigematsu, T. Hanada, T. Ohashi, T. Tanaka, Y. Shiraishi, H. Takeuchi, Y. Kitagawa
    • Organizer
      American society for radiation oncology 54th annual meeting
    • Place of Presentation
      Boston convention and exhibition center, Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-24591850
  • [Presentation] Radiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitors

    • Author(s)
      Junichi Fukada、Ryuichi Kota, Masayo Mishima, Tetsuya Kawata, Naoyuki Shigematsu
    • Organizer
      International Congress of Radiation Reseach
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2015-05-25 – 2015-05-29
    • Data Source
      KAKENHI-PROJECT-24591850
  • [Presentation] 上腹部リンパ節の呼吸性移動-4DCTを用いた検討-

    • Author(s)
      祝田勇輝、深田淳一、酢谷真也、花田剛士、高橋常浩、北川雄光、茂松直之
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-12-11 – 2014-12-13
    • Data Source
      KAKENHI-PROJECT-24591850
  • 1.  ITO Hisao (20095574)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  KAWATA Tetsuya (60234077)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 3.  KUTUKI Shoji (00234443)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  FUKADA Junichi (50338159)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 5.  NAKAYAMA Toshitake (90189077)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TOYA Kazuhito (30265912)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KOBAYASHI Koichi (80051704)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  WATANABE Masazumi (90201227)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  HORINOUCHI Hirohisa (60173647)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  NISHIMURA Shuichi (40571138)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NISHIGUCHI Iku (20198451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  OGAWA Koichi (00158817)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KA Wei-Jei (10224320)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TAJIMA Atsushi (50276276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  YASUDA Shigeo (20251176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TAKANO Hideyuki (40197116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  UNO Takashi (30302540)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OSAMU Kawaguchi (90276428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  ISHIBASHI Ryochi (90286584)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KASAMATSU Tomotaka (30317242)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KAWAMURA Masafumi (70169770)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  YAMAMOTO Manabu (10317159)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  原 竜介 (50312939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  佐藤 導直 (80255554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  山内 徳子 (30306732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  大塚 崇 (40306717)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  公田 龍一 (00464834)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 28.  小池 直義 (60464913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 29.  ISOBE Koichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  MOTEGI Atushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  SAMPETREAN Oltea
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  秋元 哲夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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