Higashi Yujiro 東雄二郎

… Alternative Names

Researcher Number	30181069
Other IDs
Affiliation (Current)	2020: 愛知県医療療育総合センター発達障害研究所, 障害モデル研究部, 客員研究員
Affiliation (based on the past Project Information) *help	2019: 愛知県医療療育総合センター発達障害研究所, 障害モデル研究部, 客員研究員 2017: 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 客員研究者 2011 – 2017: 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 部長 2008: Institute for Developmental Research, Aichi Human Service Center, 周生期学部, 部長 2007: Osaka University, Graduate School of Frontier Biosciences, Associate Professor … More
Review Section/Research Field	Principal Investigator Biological Sciences / Pediatrics / Developmental biology / Developmental biology / 分子細胞生物学 / Molecular biology / Endocrinology Except Principal Investigator Molecular biology / Endocrinology / Pediatrics / Developmental biology
Keywords	Principal Investigator SIP1 / δEF1 / ノックアウトマウス / BMP / マウス胚発生 / Smad / ZFHX1ファミリー / 転写制御因子 / TGFβファミリーシグナル / 転写因子 … More Except Principal Investigator ノックアウトマウス / ES細胞 / N-myc / δEF1 / c-myc / Sox / クリスタリン / トランスジェニックマウス / L-myc / C-myc / SOX / 遺伝子トラップ / 相周遺伝子組換え / 始原生殖細胞 / メダカ / ゼブラフィッシュ / ニワトリ / レロトウイルスベクター / 相同遺伝子組換え / レトロウイルスベクター / マウス / Ndr1 / Ndr2 / Ndr3 / dEF1 / CtBP / SIP1 / σEF1 / TrichostatinA / Max / 内分泌学 / 下垂体形成 / 下垂体後葉 / 転写因子 / 縫線核 / セロトニン / 神経 / Sip1 / 脳 / モワット・ウィルソン症候群 / セロトニン神経 / 不安 / 水晶体分化 / 転写制御因子 / 水晶体特異性 / SEF1 / 突然変異マウス / δEF2 / 標的遺伝子組換え / Lens differentiation / Transcription factors / deltaEF1 / 転写制御 / 胚発生 / Ndr-1 / Cre / LoxP / KO mouse / transcription / embryo / 水晶体 / 誘導 / エンハンサー / 外胚葉 / 網膜原基 / HMGドメイン / Pax6 / 分化誘導 / T細胞 / 骨格形成 / Lens / Induction / Crystallin / Enhancer / Transgenic mouse / Ectoderm / Optic vesicle Less

Functional analysis of zeb1/deltaEF1 transcription factor on posterior pituitary development in mousePrincipal Investigator
- Principal Investigator
  
  Higashi Yujiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
The role of SIP1, the causative gene for Mowat-Wilson syndrome, in structural and functional development of brainPrincipal Investigator
- Principal Investigator
  
  Higashi Yujiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
The role of Sip1 gene for development of the serotonergic neurons of the raphe
- Principal Investigator
  
  NISHIZAKI Yuriko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Yokohama College of Pharmacy
  Institute for Developmental Research, Aichi Human Service Center
下垂体形成過程における転写因子δEF1の機能解析
- Principal Investigator
  
  松井ふみ子
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
The study on the role of SIP1, the causative gene for Mowat-Wilson syndrome in human, in structural and functional development of brain using mouse systemPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
外生殖器形成過程におけるZFHK1転写制御因子ファミリーの機能Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
  Osaka University
Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
初期胚の神経組織形成および体節形成過程における転写制御因子SIP1の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka Unniversity
体節形成過程におけるδEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
体節形成過程におけるdEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
BMPシグナル伝達系の下流転写因子SEF1/SIP-1ファミリーの研究Principal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
発がんと胚発生を支配する転写制御機構
- Principal Investigator
  
  近藤寿人
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
四肢及び脊椎の形成における転写制御因子δEF1の機能解析Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Assessment of individual functions of Myc family genes
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
Multiple steps in cell differentiaion : the case of lens development
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
マウス胚中胚葉系組織の発生と分化における転写制御因子δEF1の機能Principal Investigator
- Principal Investigator
  
  東雄二郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
ES細胞を用いた未知遺伝子の検索
- Principal Investigator
  
  山村研一
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Investigation of the basic process of cell differentiation utilizing mutant animals of crystallin regulators
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
Analysis deltaEF1 protein function in vivo by gene targetingPrincipal Investigator
- Principal Investigator
  
  HIGASHI Yujiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子細胞生物学
- Research Institution
  Osaka University
  Nagoya University

All 2017 2016 2015 2014 2012 2007 Other

All Journal Article Presentation

[Journal Article] Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.2016
- Author(s)
  Rasouly, H. M., Kumar, S., Chan, S., Pisarek-Horowitz, A., Sharma, R., Xi, Q. J., Nishizaki, Y., Higashi, Y., Salant, D. J., Maas, R. L., Lu, W.
- Journal Title
  
  Kidney Int.
  
  Volume: 90 Pages: 1262-1273
- DOI
  10.1016/j.kint.2016.06.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539
[Journal Article] Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals2016
- Author(s)
  Menuchin-Lasowski Y., Oren-Giladi P., Xie Q., Ezra-Elia R., Ofri R., Peled-Hajaj S., Farhy C., Higashi Y., Van de Putte T., Kondoh H., Huylebroeck D., Cvekl A., Ashery-Padan R.
- Journal Title
  
  Development
  
  Volume: 143 Pages: 2829-2841
- DOI
  10.1242/dev.136101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539, KAKENHI-PROJECT-26251024
[Journal Article] Regulation of trunk neural crest delamination by δEF1 and Sip1 in the chicken.2016
- Author(s)
  Yasumi, T., Inoue, M., Maruhashi, M., Kamachi, Y., Higashi, Y., Kondoh, H., Uchikawa, M.
- Journal Title
  
  Dev Growth Differ.
  
  Volume: 58 Pages: 205-214
- DOI
  10.1111/dgd.12256
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14527, KAKENHI-PROJECT-25440106, KAKENHI-PROJECT-25290066, KAKENHI-PROJECT-26461539
[Journal Article] The Zeb1 Transcription Factor Controls the Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone2016
- Author(s)
  Ohayon, D., Garces, A., Willy Joly, W., Soukkarieh, C., Takagi, T., Sabourin, J.-C., Eric Agius, E., Darling, D. S., De Santa Barbara, P., Higashi, Y., Stolt, C. C., Jean-Philippe Hugnot, J.-P., William D. Richardson, W. D., Patrick Carroll, P. and Pattyn, A.
- Journal Title
  
  Cell Reports
  
  Volume: 17 Pages: 1473-1481
- DOI
  10.1016/j.celrep.2016.10.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539
[Journal Article] Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.2016
- Author(s)
  Wu, X., Brisefio, C. G., Grajales-Reyes, G. E., Haldar, M., Iwata, A., Kretzer, N. M., Wumesh, KC., Tussiwand, R., Higashi, Y., Murphy, T. L., and Murphy, K. M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Pages: 14775-14780
- DOI
  10.1073/pnas.1611408114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461539
[Journal Article] De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome.2015
- Author(s)
  51.Takagi T, Nishizaki Y, Matsui F, Wakamatsu N, Higashi Y.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 24 Pages: 6390-6402
- DOI
  10.1093/hmg/ddv350
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461539, KAKENHI-PROJECT-26461557, KAKENHI-PROJECT-26462225
[Journal Article] SIP1 expression pattern in brain investigated by generating a SIP1-EGFP reporter knock-in mouse2014
- Author(s)
  Nishizaki, Y., Takagi, T., Matsui, F. and Higashi, Y.
- Journal Title
  
  Genesis
  
  Volume: 52 Pages: 56-57
- DOI
  10.1002/dvg.22726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591525, KAKENHI-PROJECT-23791215, KAKENHI-PROJECT-25461399
[Journal Article] Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.2012
- Author(s)
  McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL.
- Journal Title
  
  Neuron
  
  Volume: 77 Pages: 83-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] 63.zeb1 flox マウスの作製とそのzeb1およびzeb2 double floxマウスを用いたマウス発生過程におけるZEB転写制御因子ファミリーの機能解析2017
- Author(s)
  東雄二郎、高木豪、水谷友香、浅井真人
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09896
[Presentation] Cre-LoxPシステムを利用したdenovo変異型ヒト疾患モデルマウスの作製2015
- Author(s)
  高木豪、東雄二郎
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26461539
[Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndrome のモデル動物としての有用性の検討2012
- Author(s)
  高木豪、東雄二郎
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] Identification of four zfhxl genes in zebrafish and comparison of their expression patterns during early embryogenesis2007
- Author(s)
  東雄二郎
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-19040015
[Presentation] ゼブラフィッシュzfhx1遺伝子ファミリーの同定と胚発生過程における発現パターンの解析2007
- Author(s)
  東雄二郎
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570198
[Presentation] Identification of four zfhx1 genes in zebrafish and comparison of their expression patterns during early embryogenesis2007
- Author(s)
  東雄二郎
- Organizer
  第40回日本発生生物学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-18570198
[Presentation] Identification of four zthxl genes in zebrafish and comparison of their expression patterns during early embryogenesis2007
- Author(s)
  Higashi, Y
- Organizer
  The 40th annual meeting of the Japanese Society of Developmental Biologist
- Place of Presentation
  Fukuoka
- Year and Date
  2007-05-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570198
[Presentation] レポーターノックインマウスを用いたモワット-ウィルソン症候群の原因遺伝子SIP1の発現解析
- Author(s)
  西崎有利子、高木豪、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-23591525
[Presentation] モデルマウスを用いたモワット・ウィルソン症候群の病態形成の解析
- Author(s)
  高木豪、西崎有利子、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25461399
[Presentation] Loss of Zeb2 Causes Glomerulocystic Kidney Disease in Mice.
- Author(s)
  Rasouly M.H., Chan S., Pisarek-Horowitz A., Nishizaki Y., Higashi Y., Lu W.
- Organizer
  Annual meeting of the American Society of Nephrology
- Place of Presentation
  Philadelphia, PA
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26461557
[Presentation] レポーターノックインマウスを用いたモワット-ウィルソン症候群の原因遺伝子SIP1の発現解析
- Author(s)
  西崎有利子、高木豪、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25461399
[Presentation] モデルマウスを用いたモワット・ウィルソン症候群の病態形成の解析
- Author(s)
  高木豪、西崎有利子、松井ふみ子、東雄二郎
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-23591525

1. KONDOH Hisato (70127083)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. KAMACHI Yusuke (90263334)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. NISHIZAKI Yuriko (90378901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 松井ふみ子 (10393133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. ANDRAS Nagy

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山村研一 (90115197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 仲村春和 (90079690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 若松佑子 (20026800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松居靖久 (40241575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中辻憲夫 (80237312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 續輝久 (40155429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 武田洋幸 (80179647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 村松喬 (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 内川昌則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 若松延昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashi Yujiro 東 雄二郎

HIGASHI Yujiro 東 雄二郎

Research Projects

Research Products

Co-Researchers

Functional analysis of zeb1/deltaEF1 transcription factor on posterior pituitary development in mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of SIP1, the causative gene for Mowat-Wilson syndrome, in structural and functional development of brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Sip1 gene for development of the serotonergic neurons of the raphe

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

下垂体形成過程における転写因子δEF1の機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study on the role of SIP1, the causative gene for Mowat-Wilson syndrome in human, in structural and functional development of brain using mouse systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

外生殖器形成過程におけるZFHK1転写制御因子ファミリーの機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

初期胚の神経組織形成および体節形成過程における転写制御因子SIP1の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of ZFHX1 family transcription factors in embryonic developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

体節形成過程におけるδEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

体節形成過程におけるdEF1/SIP1ファミリー転写制御因子の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

BMPシグナル伝達系の下流転写因子SEF1/SIP-1ファミリーの研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発がんと胚発生を支配する転写制御機構

Principal Investigator

Project Period (FY)

Higashi Yujiro 東雄二郎

HIGASHI Yujiro 東雄二郎