Ishikawa Naoshi 石川直

… Alternative Names

ISHIKAWA Naoshi 石川直

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Researcher Number	30184485
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2018: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2010: Tokyo Metropolitan Institute of Gerontology, 研究員 2010: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2009: 地方独立行政法人東京都健康長寿医療センター(東京都, 研究員 2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究員 … More 2007: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究員 2006: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員 2000: 東京都老人総合研究所, 遺伝子情報部門, 研究員 1999 – 2000: 財団法人東京都老人総合研究所, 遺伝子情報部門, 研究員 1998: 財団法人, 東京都老人総合研究所・遺伝子情報部門, 研究員 1995: (財)東京都老人総合研究所, 分子病理部門, 研究員 1995: Dept.of Mol.Pathol., Tokyo Metropolitan Institute of Gerontology Institute of Th, 分子病理部門, 研究員 1993: (財)東京都老人総合研究所, 分子病理部門, 研究員 1992 – 1993: 東京都老人総合研究所, 分子病理部門, 研究員 1991: (財)東京都老人総合研究所, 分子病理部門, 研究員 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Pathological medical chemistry / Experimental pathology Except Principal Investigator Biological pharmacy / General medical chemistry / Functional biochemistry / Experimental pathology
Keywords	Principal Investigator テロメア / iPS細胞 / 細胞老化 / 線維芽細胞 / リプログラミング / ウェルナー症候群 / 染色体組換え / がん化 / 老化 / WRN遺伝子 … More / アイソフォーム / nm23 / ヒト線維芽細胞 / 染色体特異性 / 染色体Q-FISH / リプログラム / 染色体不安定化 / 細胞系列特異性 / ダウン症 / 加齢 / FISH / ウエルナーヘリカーゼ / Southern blotting / quantitative fluorescence in situ hybridization(Q-FISH) / ウエルナー症候群 / 免疫染色 / CATアッセイ / コアプロモーター / RACE法 / 転写開始点多型性 / ヌクレオシド二リン酸キナーゼ / がん転移 / 臓器・細胞特異的発現 / 遺伝子発現 / 遺伝子構造 / ヌクレオシドニリン酸(NDP)キナーゼ … More Except Principal Investigator nm23 / NDPキナーゼ / NDP kinase / 細胞増殖 / Cell growth / シグナル伝達 / がん転移抑制 / 細胞分化 / Metastasis suppressor / Differentiation / Signal transduction / dbcAMP / NGF / 神経突起形成 / PC12細胞 / 酵素活性 / gene / GTP-binding protein / tumor metastasis / signal transduction / um23 / 遺伝子 / GTP結合蛋白質 / がん転移 / 情報伝達 / Defferentiation / Nm23 / アイソフォーム / 培養細胞 / 分化 / ヌクレオシドニリン酸(NDP)キナーゼ / 肺自然転移の抑制 / 癌転移抑制遺伝子 / NDPキナーゼβアイソフォーム / NDPキナーゼαアイソフォーム / 蛋白一次構造 / 遺伝子単離 / アイソフォ-ム / cDNA / NDPキナ-ゼ Less

Molecular mechanism of telomere length regulation: Lesson from reprograming of iPS cellsPrincipal Investigator
- Principal Investigator
  
  Ishikawa Naoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Analyses of gene function for telomere dependent cellular senescencePrincipal Investigator
- Principal Investigator
  
  Ishikawa Naoshi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Analyses of Werner helicase functions : From the viewpoint of its telomere stabilizationPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Naoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
ウエルナーヘリカーゼのもつ抗老化・抗がん化作用の分子基盤の探索Principal Investigator
- Principal Investigator
  
  石川直
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
NDPキナーゼ/nm23に関する国際会議開催に向けての企画調査研究
- Principal Investigator
  
  木村成道
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Studies on the mechanism of NDP kinase/nm23 and its interacting proteins
- Principal Investigator
  
  KIMURA Narimichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
癌転移抑制遺伝子nm23/NDPキナーゼの転移抑制メカニズムに関する研究
- Principal Investigator
  
  福田貢
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
The Role of NDP kinases in Membrane Signal Transduction
- Principal Investigator
  
  KIMURA Narimichi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
ヌクレオシド二リン酸キナーゼの遺伝子発現調節の解析Principal Investigator
- Principal Investigator
  
  石川直
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
NDPキナーゼの遺伝子発現調節と腫瘍細胞の転移能の変異との相関についてPrincipal Investigator
- Principal Investigator
  
  石川直
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Role of NDP kinase in cell growth and differentiation
- Principal Investigator
  
  KIMURA Narimichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
NDPキナ-ゼの構造と機能および遺伝子に関する研究
- Principal Investigator
  
  KIMURA Narimichi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Changes in telomere length with aging in human neurons and glial cells revealed by quantitative fluorescence in situ hybridization analysis.2018
- Author(s)
  Tomita K, Aida J, Izumiyama-Shimomura N, Nakamura KI, Ishikawa N, Matsuda Y, Arai T, Ishiwata T, Kumasaka T, Takahashi-Fujigasaki J, Hiraishi N, Yamada M, Fujiwara M, Takubo K.
- Journal Title
  
  Geriatr Gerontol Int.
  
  Volume: 18 Issue: 10 Pages: 1507-1512
- DOI
  10.1111/ggi.13500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08414
[Journal Article] テロメア短縮と老化および高齢者に好発する疾患との関連2018
- Author(s)
  石川直, 相田順子, 田久保海誉, 松田陽子, 新井冨生, 石渡俊行
- Journal Title
  
  病理と臨床
  
  Volume: 36 Pages: 102-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08414
[Journal Article] Quantitative fluorescence in situ hybridization for investigation of telomere length dynamics in the pituitary gland using samples from 128 autopsied patients.2018
- Author(s)
  Hiraishi N, Terai M, Fujiwara M, Aida J, Izumiyama-Shimomura N, Ishikawa N, Tomita K, Matsuda Y, Arai T, Takubo K, Ishiwata T.
- Journal Title
  
  Tissue Cell
  
  Volume: 53 Pages: 1-7
- DOI
  10.1016/j.tice.2018.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08414
[Journal Article] Telomere length determined by the fluorescence in?situ hybridisation distinguishes malignant and benign cells in cytological specimens2018
- Author(s)
  Matsuda Y.、Suzuki A.、Esaka S.、Hamashima Y.、Imaizumi M.、Kinoshita M.、Shirahata H.、Kiso Y.、Kojima H.、Matsukawa M.、Fujii Y.、Ishikawa N.、Aida J.、Takubo K.、Ishiwata T.、Nishimura M.、Arai T.
- Journal Title
  
  Cytopathology
  
  Volume: 29 Issue: 3 Pages: 262-266
- DOI
  10.1111/cyt.12535
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08414, KAKENHI-PROJECT-16KT0125
[Journal Article] テロメア短縮と老化および高齢者に好発する疾患との関連.2018
- Author(s)
  石川直, 相田順子, 田久保海誉, 松田陽子, 新井冨生, 石渡俊行.
- Journal Title
  
  病理と臨床
  
  Volume: 36 Pages: 102-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08414
[Journal Article] Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization2017
- Author(s)
  Aoki Yuto、Aida Junko、Kawano Youichi、Nakamura Ken-ichi、Izumiyama-Shimomura Naotaka、Ishikawa Naoshi、Arai Tomio、Nakamura Yoshiharu、Taniai Nobuhiko、Uchida Eiji、Takubo Kaiyo、Ishiwata Toshiyuki
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 53 Issue: 2 Pages: 291-301
- DOI
  10.1007/s00535-017-1411-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08414, KAKENHI-PROJECT-16K10442
[Journal Article] Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage2016
- Author(s)
  Hitoshi Hatakeyama, Hiromi Yamazaki, Ken‐Ichi Nakamura, Naotaka Izumiyama‐Shimomura, Junko Aida, Hiroetsu Suzuki, Shuichi Tsuchida, Masaaki Matsuura, Kaiyo Takubo, and Naoshi Ishikawa
- Journal Title
  
  AGING
  
  Volume: 8 Pages: 1-15
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08414
[Journal Article] Changes of telomere status with aging: An update2016
- Author(s)
  Naoshi Ishikawa, Ken-Ichi Nakamura, Naotaka Izumiyama-Shimomura, Junko Aida, Yoko Matsuda, Tomio Arai and Kaiyo Takubo
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 16 Issue: S1 Pages: 30-42
- DOI
  10.1111/ggi.12772
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08414, KAKENHI-PROJECT-26460430, KAKENHI-PROJECT-24590468
[Journal Article] Telomere attrition in beta and alpha cells with age.2016
- Author(s)
  Tamura Y, Izumiyama-Shimomura N, Kimbara Y, Nakamura K, Ishikawa N, Aida J, Chiba Y, Matsuda Y, Mori S, Arai T, Fujiwara M, Poon SSS, Ishizaki T, Araki A, Takubo K, Ito H.
- Journal Title
  
  Age
  
  Volume: 38 Issue: 3 Pages: 61-68
- DOI
  10.1007/s11357-016-9923-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08414
[Journal Article] Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage.2016
- Author(s)
  Hitoshi Hatakeyama, Hiromi Yamazaki, Ken‐Ichi Nakamura, Naotaka Izumiyama‐Shimomura, Junko Aida, Hiroetsu Suzuki, Shuichi Tsuchida, Masaaki Matsuura, Kaiyo Takubo, and Naoshi Ishikawa.
- Journal Title
  
  AGING
  
  Volume: 8 (1) Pages: 1-15
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas.2015
- Author(s)
  1.Matsuda Y, Ishiwata T, Izumiyama-Shimomura N, Hamayasu H, Fujiwara M, Tomita K, Hiraishi N, Nakamura K, Ishikawa N, Aida J, Takubo K, Arai T.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 2 Pages: e0117575-e0117575
- DOI
  10.1371/journal.pone.0117575
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08414, KAKENHI-PROJECT-24590468
[Journal Article] Arm-specific telomere dynamics of each individual chromosome in induced pluripotent stem cells revealed by quantitative fluorescence in situ hybridization.2014
- Author(s)
  Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Kuroiwa M, Arai T, Toyoda M, Nakamura K, Takubo K.
- Journal Title
  
  Tissue Cell
  
  Volume: 46 Issue: 6 Pages: 470-476
- DOI
  10.1016/j.tice.2014.08.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Beta Cell Telomere Attrition in Diabetes: Inverse Correlation Between HbA1c and Telomere Length.2014
- Author(s)
  Tamura Y, Izumiyama-Shimomura N, Kimbara Y, Nakamura K, Ishikawa N, Aida J, Chiba Y, Mori S, Arai T, Aizawa T, Araki A, Takubo K, Ito H.
- Journal Title
  
  J Clinical Endocrinology and Metabolism.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Maternal grafts protect daughter recipients from acute cellular rejection after pediatric living donor liver transplantation for biliary atresia.2014
- Author(s)
  Sanada Y, Kawano Y, Miki A, Aida J, Nakamura K, Izumiyama NS, Ishikawa N, Arai T, Hirata Y, Yamada N, Okada N, Wakiya T, Ihara Y, Urahashi T, Yasuda Y, Takubo K.
- Journal Title
  
  Transpl Int
  
  Volume: 27 Issue: 4 Pages: 383-90
- DOI
  10.1111/tri.12273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659193, KAKENHI-PROJECT-24590468, KAKENHI-PROJECT-24592013
[Journal Article] Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH2014
- Author(s)
  Nakamura K, Ishikawa N, Izumiyama N, Aida J,　Kuroiwa M, Hiraishi N, Fujiwara M, Nakao A, Kawakami T, Poon SSS, Matsuura M, Sawabe M, Arai T, Takubo T.
- Journal Title
  
  Gene
  
  Volume: 533 Issue: 1 Pages: 199-207
- DOI
  10.1016/j.gene.2013.09.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Q-FISH measurement of hepatocyte telomere lengths in donor liver and graft after pediatric living-donor liver transplantation: Donor age affects telomere length sustainability.2014
- Author(s)
  Kawano Y., Ishikawa N., Aida J., Sanada Y., Izumiyama-Shimomura N., Nakamura K., Poon SSS., Matsumoto K., Mizuta K., Uchida E., Tajiri T., Kawarasaki H., Takubo K.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 4 Pages: 1-10
- DOI
  10.1371/journal.pone.0093749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23659193, KAKENHI-PROJECT-24590468, KAKENHI-PROJECT-24592013
[Journal Article] Q-FISH measurement of telomere length in skin with/without sun exposure or actinic keratosis2014
- Author(s)
  Ikeda H, Aida J, Hatamochi A, Hamasaki Y, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Tomita K, Hiraishi N, Kuroiwa M, Matsuura M, Sanada Y, Kawano Y, Arai T, Takubo K.
- Journal Title
  
  Human Pathology.
  
  Volume: 45 Pages: 473-480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Beta Cell Telomere Attrition in Diabetes: Inverse Correlation Between HbA1c and Telomere Length.2014
- Author(s)
  Tamura Y, Izumiyama-Shimomura N, Kimbara Y, Nakamura K, Ishikawa N, Aida J, Chiba Y, Mori S, Arai T, Aizawa T, Araki A, Takubo K, Ito H.
- Journal Title
  
  J Clinical Endocrinology and Metabolism.
  
  Volume: 99 Issue: 8 Pages: 2771-2777
- DOI
  10.1210/jc.2014-1222
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Determination of telomere length by the quantitative fluorescence in situ hybridization (Q-FISH) method.2014
- Author(s)
  Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Terai M, Mztsuda Y, Aida S, Arai T, Takubo K.
- Journal Title
  
  Am J Anal Chem
  
  Volume: 5 Issue: 12 Pages: 775-783
- DOI
  10.4236/ajac.2014.512086
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.2013
- Author(s)
  Aida J, Yokoyama A, Shimomura N, Nakamura K, Ishikawa N, Terai M, Poon S, Matsuura M, Fujiwara M, Sawabe M, Arai T, Takubo K
- Journal Title
  
  PloS one
  
  Volume: 8 Issue: 5 Pages: 1-7
- DOI
  10.1371/journal.pone.0063860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592351, KAKENHI-PROJECT-22590343, KAKENHI-PROJECT-24590468, KAKENHI-PROJECT-25280008
[Journal Article] Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms.2013
- Author(s)
  Izumiyama-Shimomura N, Nakamura K, Aida J, Ishikawa N, Kuroiwa M, Hiraishi N, Fujiwara M, Ishikawa Y, Inoshita N, Yonese J, Matsuura M, Poon SS, Arai T, Takubo K.
- Journal Title
  
  Urol Oncol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] 加齢の科学再考．2012
- Author(s)
  石川直、仲村賢一、下村七生貴、相田順子、田久保海誉
- Journal Title
  
  基礎老化研究
  
  Volume: 36 Pages: 55-60
- NAID
  10031121039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590468
[Journal Article] Accelerated in vivo epidermal telomere loss in Werner syndrome2011
- Author(s)
  Ishikawa N, (筆頭著者)
- Journal Title
  
  Aging
  
  Volume: 3 Pages: 417-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Journal Article] Alcoholics show reduced telomere length in the oesophagus.2011
- Author(s)
  Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K.
- Journal Title
  
  Journal of Pathology. 223
  
  Pages: 410-416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Journal Article] Accelerated in vivo epidermal telomere loss in Werner syndrome.2011
- Author(s)
  Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K.
- Journal Title
  
  Aging. 3
  
  Pages: 417-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Journal Article] Telomere dynamics in the human pituitary gland : robust preservation throughout adult life to centenarian age2011
- Author(s)
  Ishikawa N, Nakamura K, Izumiyama N, Aida J, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Ishii A, Takubo K.
- Journal Title
  
  AGE
  
  Volume: 34 Issue: 4 Pages: 795-804
- DOI
  10.1007/s11357-011-9280-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390109, KAKENHI-PROJECT-24590468
[Journal Article] Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence.2010
- Author(s)
  Takubo K, Aida J, Izumiyama N, Ishikawa N , Fujiwara M,. Poon SSS, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird DM, Nakamura K.
- Journal Title
  
  Mechanisms of Ageing and Development. 131
  
  Pages: 614-624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Journal Article] Q-FISH analysis of telomere and chromosome instability in theoesophagus with and without squamous cell carcinoma in situ.2010
- Author(s)
  Takubo K, Fujita M , Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J.
- Journal Title
  
  Journal of Pathology. 221
  
  Pages: 201-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Journal Article] Telomere lengths in the oral epithelia with and without carcinoma.2010
- Author(s)
  Aida J, Izumo T, Shimomura N, Nakamura K, Ishikawa N, Matsuura M, Poon SS, Fujiwara M, Sawabe M, Arai T, Takubo K.
- Journal Title
  
  Europian Journal of Cancer. 46
  
  Pages: 430-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Journal Article] The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life.2008
- Author(s)
  Hatakeyama H, Nakamura K, Izumiyama-Shimomura N, Ishii A, Tsuchida S, Takubo K, Ishikawa N.
- Journal Title
  
  Mechanisms of Ageing and Development. 129
  
  Pages: 550-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590389
[Presentation] Telomere dynamics of human diploid cell strains at chromosome level: Lesson from iPS cells (Second report).2018
- Author(s)
  Naoshi ISHIKAWA, Masashi TOYODA, Junko AIDA, Toshiyuki ISHIWATA
- Organizer
  第41回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] Telomere dynamics during “lifelong” culture of human diploid cell strains at chromosome level: Lesson from iPS cells.2018
- Author(s)
  Naoshi ISHIKAWA, Ken-ichi Nakamura, Junko AIDA, Kaiyo TAKUBO, Masashi TOYODA, Toshiyuki ISHIWATA
- Organizer
  第107回日本病理学会
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] Barrett’s adenocarcinoma arise from intestinal or cardiac-type mucosae? Telomere measurement by using quantitative fluorescence in situ hybridization.2017
- Author(s)
  Aida J, Shimomura N, Nakamura K, Ishikawa N, Takubo K, Ishiwata T
- Organizer
  第５回　日本比較病理学研究会.
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] Telomere dynamics during “lifelong” culture of human diploid cell strains at chromosome level: Lesson from iPS cells.2017
- Author(s)
  Naoshi ISHIKAWA, Masashi TOYODA, Toshiyuki ISHIWATA
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] 大脳神経細胞及びグリア細胞の加齢によるテロメア長変化2017
- Author(s)
  富田健一郎、相田順子、泉山七生貴、仲村賢一、石川直、新井冨生、石渡俊行、熊坂利夫、藤原睦憲、田久保海誉
- Organizer
  第１０６回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] テロメア長測定による、老化と前がん状態の検出.2016
- Author(s)
  相田順子、石川直、田久保海誉、石渡俊行、新井冨生
- Organizer
  TOBIRA 第５回研究交流フォーラム
- Place of Presentation
  ソラシティカンファレンスセンターホール（東京都、文京区）
- Year and Date
  2016-05-23
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] Telomere measurement of intestinal and cardiac-type mucosae in Barrett’s oesophagus using quantitative fluorescence in situ hybridization.2016
- Author(s)
  Aida J, Takubo K, Ishikawa N, Matuda Y, Arai T, Ishiwata T, Vieth M.
- Organizer
  XXXI International Congress of IAP and 26th Congress of ESP
- Place of Presentation
  Cologne, Germany.
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] Q-FISH法によるバレット食道における腸型および噴門型粘膜のテロメア計測.2016
- Author(s)
  相田順子、泉山七生貴、仲村賢一、石川直、松田陽子、長谷川佳代、直井美穂、田久保海誉、新井冨生
- Organizer
  第１０５回日本病理学会総会
- Place of Presentation
  仙台国際センター会議棟・展示棟 (宮城県、仙台市)
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] 膵腺房中心細胞におけるテロメアの短縮と加齢、発癌、組織幹細胞との関連2015
- Author(s)
  松田陽子、泉山七生貴、富田健一郎、平石直己、仲村賢一、石川直、相田順子、田久保海誉、新井冨生
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] 膵腺房中心細胞におけるテロメアの短縮と加齢、発癌、組織幹細胞との関連2015
- Author(s)
  松田陽子、泉山七生貴、富田健一郎、平石直己、仲村賢一、石川直、相田順子、田久保海誉、新井冨生
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] 下垂体細胞のテロメアは加齢で短縮するか？－男女別、前葉、後葉別テロメア長の検討－2015
- Author(s)
  平石直己、藤原睦憲、相田順子、泉山七生貴、仲村賢一、石川直、直井美穂、松田陽子、新井冨生、田久保海誉
- Organizer
  104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] 上皮小体好酸性細胞は老化細胞か2015
- Author(s)
  相田順子、泉山七生貴、石川直、直井美穂、富田健一郎、長谷川佳代、藤原睦憲、松田陽子、新井冨生、田久保海誉
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] テロメア短縮の2相性（若年期の急速短縮と中高年期の緩徐な短縮）からヒト老化プロセスを再考する2015
- Author(s)
  石川直、仲村賢一、泉山七生貴、相田順子、田久保海誉
- Organizer
  第38回日本基礎老化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] 下垂体細胞のテロメアは加齢で短縮するか？－男女別、前葉、後葉別テロメア長の検討－2015
- Author(s)
  平石直己、藤原睦憲、相田順子、泉山七生貴、仲村賢一、石川直、直井美穂、松田陽子、新井冨生、田久保海誉
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] テロメア短縮の2相性（若年期の急速短縮と中高年期の緩徐な短縮）からヒト老化プロセスを再考する2015
- Author(s)
  石川直、仲村賢一、泉山七生貴、相田順子、田久保海誉
- Organizer
  第38回日本基礎老化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] 上皮小体好酸性細胞は老化細胞か2015
- Author(s)
  相田順子、泉山七生貴、石川直、直井美穂、富田健一郎、長谷川佳代、藤原睦憲、松田陽子、新井冨生、田久保海誉
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08414
[Presentation] Telomere shortening in precancerous pancreatic lesions.2014
- Author(s)
  Matsuda Y, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Aida J, Yoshimura H, Ishiwata T, Arai T, Takubo K．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] iPS細胞のテロメアは長くなるか、短くなるか？2013
- Author(s)
  寺井政憲、仲村賢一、泉山-下村七生貴、石川直、豊田雅士、相田順子、田久保海誉
- Organizer
  第２５回高遠分子細胞生物学シンポジウム
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] The telomeres of the parental cells were elongated by establishment iPSCs, but the telomere extension rate differed among the clones.2013
- Author(s)
  Ishikawa, N., Terai, M., Toyoda, M., Nakamura, K., Shimomura-Izumiyama, N., and Takubo, K.
- Organizer
  CiRA International Symposium 2013 "Raising the Next Generation of Stem Cell Research."
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] ｉＰＳ細胞化によるリプログラミング過程でのテロメア動態のＱ-ＦＩＳＨ法による解析2013
- Author(s)
  石川直、仲村賢一、下村-泉山七生貴、相田順子、寺井政憲、豊田雅士、田久保海誉
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Factors related to shortening of telomeres in esophageal epithelium2013
- Author(s)
  Aida J, Shimomura N, Nakamura K, Fujiwara M, Ishikawa N, Arai T, and Takubo K.
- Organizer
  The 20th IAGG World Congress of Gerontology and Geriatrics
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Accelerated in vivo and in vitro telomere loss in Werner syndrome2013
- Author(s)
  Ishikawa N, Nakamura K, Shimomura N, Aida J, Goto M, Ishikawa Y, Matsuura M, Hatamochi A, Takubo K.
- Organizer
  The 20th IAGG World Congress of Gerontology and Geriatrics
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Ｑ-ＦＩＳＨ法により測定したテロメア長を指標とした超百歳リンパ球から樹立されたｉＰＳ細胞の評価2013
- Author(s)
  仲村賢一、広瀬信行、下村-泉山七生貴、相田順子、石川直、田久保海誉
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Chromosomal instability could be induced by telomere shortening although established iPSCs maintain telomerase activity.2013
- Author(s)
  Terai, M. Ishikawa, N., Toyoda, M., Aida, J. and Takubo, K.
- Organizer
  CiRA International Symposium 2013 "Raising the Next Generation of Stem Cell Research."
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Q-FISH法により測定したテロメア長を指標としたiPS細胞の評価.2012
- Author(s)
  仲村賢一、豊田雅士、下村-泉山七生貴、相田順子、石川直、櫻井うらら、沢辺元司、新井冨生、田久保海誉
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京, 新宿
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] ウェルナー症候群ではin vivo　テロメア短縮が亢進している：重回帰解析によりわかったこと．2012
- Author(s)
  石川直、仲村賢一、下村七生貴、相田順子、石川雄一、松浦正明、籏持淳、田久保海誉
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] ウェルナー症候群患者皮膚テロメア長は正常人群と比べ急速に短縮する－TRFデータの重回帰統計解析－．2012
- Author(s)
  石川直、仲村賢一、下村七生貴、相田順子、後藤眞、石川雄一、籏持淳、田久保海誉
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京, 新宿
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] ヒト下垂体のテロメア長の動態統計解析-下垂体テロメア長はよく保存され最短テロメア長は寿命と正相関する-2010
- Author(s)
  石川直、仲村賢一、下村七生貴、相田順子、田久保海誉
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋大学野依記念学術交流館
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20590389
[Presentation] ヒト下垂体のテロメア長の動態統計解析-下垂体テロメア長はよく保存され、最短テロメア長は寿命と正相関する-2010
- Author(s)
  石川直、仲村賢一、下村七生貴、相田順子、田久保海誉
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋大学・野依記念学術交流館
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20590389
[Presentation] ウェルナー遺伝子欠損はin vivoおよびin vitroでテロメア長を短縮させる。2009
- Author(s)
  石川直、仲村賢一, 他・名
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-05-02
- Data Source
  KAKENHI-PROJECT-20590389
[Presentation] ウェルナー遺伝子欠損は in vivo および in vitro でテロメア長を短縮させる2009
- Author(s)
  石川直、仲村賢一、, 他5名
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-05-02
- Data Source
  KAKENHI-PROJECT-20590389
[Presentation] Telomere length in cerebral gray and white matter is inversely related with cancer death and associated with longevity2007
- Author(s)
  N.Ishikawa, 他7名
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18659116
[Presentation] ヒト大脳の灰白質、白質のテロメア長の解析(第二報)-大脳テロメア長は70歳以上の長寿者り寿命と正相し、癌死と負相関する-2007
- Author(s)
  石川直, 他5名
- Organizer
  第30回日本基礎老化学会大会(第25回日本老年学会総会)
- Place of Presentation
  札幌
- Year and Date
  2007-06-20
- Data Source
  KAKENHI-PROJECT-18659116
[Presentation] 膵臓を構成する細胞系列別のテロメア長のQ-FISH法による解析：加齢および糖尿病病態との相関の検討．
- Author(s)
  石川直、泉山七生貴、相田順子、仲村賢一、藤原睦憲、新井冨生、田久保海誉
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] 脂肪腫と異型脂肪腫様腫瘍の細胞遺伝学的、染色体の安定性とテロメア長の差異．
- Author(s)
  仲村賢一、杉浦善弥、泉山七生貴、石川雄一、藤原睦憲、石川直、相田順子、新井冨生、田久保海誉
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] 口腔粘膜におけるテロメア短縮とアルコール代謝酵素ADH1B、ALDH2の遺伝子型．
- Author(s)
  相田順子、泉山七生貴、仲村賢一、石川直、杉浦善弥、藤原睦憲、新井冨生、田久保海誉
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Telomere length of iPS cells measured by Q-FISH method.
- Author(s)
  Nakamura K, Hirose N, Shimomura N, Aida J, Ishikawa N, Takubo K.
- Organizer
  第37回日本基礎老化学会大会
- Place of Presentation
  愛知、大府
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24590468
[Presentation] Q-FISH measurement of hepatocyte telomeres in donor & graft after living-donor liver transplantation.
- Author(s)
  Ishikawa N, Izumiyama-Shimomura N, Aida J, Nakamura K, Takubo K.
- Organizer
  第37回日本基礎老化学会大会
- Place of Presentation
  愛知、大府
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24590468

1. KIMURA Narimichi (60073029)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. AHIMADA Nobuko (60158962)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. FUKUDA Mitsugu (30100126)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. NAKAMURA KenーIchi (60159069)

# of Collaborated Projects: 4 results

# of Collaborated Products: 50 results
5. TAKUBO Kaiyo (00154956)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
6. MATSUZAKI Takao

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAGUSHI Takahiko (80073005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NOMURA Kohji (30073026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石井章雄 (60167244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 戸田年総 (80133635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHEARN A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. LIOTTA L.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ORLOV N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. LIOTTA Lance A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SHEARN Allen D.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ORLOV Nikolay Y.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. AIDA Junko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 寺井政憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishikawa Naoshi 石川 直

ISHIKAWA Naoshi 石川 直

Research Projects

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Co-Researchers

Molecular mechanism of telomere length regulation: Lesson from reprograming of iPS cellsPrincipal Investigator

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Analyses of gene function for telomere dependent cellular senescencePrincipal Investigator

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Analyses of Werner helicase functions : From the viewpoint of its telomere stabilizationPrincipal Investigator

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ウエルナーヘリカーゼのもつ抗老化・抗がん化作用の分子基盤の探索Principal Investigator

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NDPキナーゼ/nm23に関する国際会議開催に向けての企画調査研究

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Studies on the mechanism of NDP kinase/nm23 and its interacting proteins

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癌転移抑制遺伝子nm23/NDPキナーゼの転移抑制メカニズムに関する研究

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The Role of NDP kinases in Membrane Signal Transduction

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ヌクレオシド二リン酸キナーゼの遺伝子発現調節の解析Principal Investigator

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NDPキナーゼの遺伝子発現調節と腫瘍細胞の転移能の変異との相関についてPrincipal Investigator

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Role of NDP kinase in cell growth and differentiation

Principal Investigator

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NDPキナ-ゼの構造と機能および遺伝子に関する研究

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[Journal Article] Changes in telomere length with aging in human neurons and glial cells revealed by quantitative fluorescence in situ hybridization analysis.2018

Author(s)

Journal Title

DOI

Ishikawa Naoshi 石川直

ISHIKAWA Naoshi 石川直