YAMAMOTO Tokuo 山本徳男

… Alternative Names

山本徳男ヤマモトトクオ

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Researcher Number	30192412
External Links
Affiliation (based on the past Project Information) *help	2007 – 2014: Tohoku University, 加齢医学研究所, 教授 2004 – 2005: 東北大学, 加齢医学研究所, 教授 2001 – 2003: 東北大学, 遺伝子実験施設, 教授 1997 – 1998: 東北大学, 遺伝子実験施設, 教授 1992 – 1995: TOHOKU UNIV. GENE RESEARCH CENTER, PROF., 遺伝子実験施設, 教授 1990 – 1991: 東北大学, 遺伝子実験施設, 助教授 1987 – 1988: 東北大学, 遺伝子実験施設, 助教授
Review Section/Research Field	Principal Investigator Eating habits, studies on eating habits / Pathological medical chemistry / General medical chemistry / Applied health science / Biological Sciences Except Principal Investigator Kidney internal medicine / Laboratory animal science / 物質生物化学 / 内分泌・代謝学 / Experimental pathology / Cerebral neurosurgery
Keywords	Principal Investigator コレステロール / LRP5 / Wnt / レセプター / cholesterol / 生活習慣病 / 2型糖尿病 / 耐糖能異常 / リポタンパク / 高脂血症 … More / リポ蛋白 / type 2 diabetes / glucose tolerance / hyperlipidemia / Alzheimer's disease / knockout mice / exon loss / apolipoprotein / central nervous system / receptor / lipoprotein / アルツハイマー / ノックアウトマウス / エクソン喪失 / アポE / 中枢神経系 / CDNAクローニング / cDNAクローニング / 心筋障害 / 動脈硬化 / LDL受容体異常 / 加齢 / エネルギー代謝 / 健康と食生活 / LPR5 / 糖尿病 / 卵形成 / 遺伝子導入動物 / がん遺伝子 / 脳腫瘍 / PDGF … More Except Principal Investigator ApoE-Sendai / Fas / cDNA / 酸化LDL / マクロファージ / Glomerulonephritis / Collagen disease / 背景遺伝子 / RFLP / TNF / 動脈炎 / 糸球体腎炎 / 自己免疫病 / 膠原病 / Acyl-CoA synthetase / Oxidized LDL / Capillary isotachophoresis / ApoE deficient mouse / Lipoprotein glomerulopathy / アポEノックアウト・マウス / apoE-Sendai / キャピラリー等速電気泳動法 / アポEノックアウトマウス / リポ蛋白糸球体症 / Autoantibody / Background gene / Apoptosis / Arthritis / Vasculitis / 疾患モデルマウス / アロタイプ変異 / 骨髄キメラ / 腎炎原性抗体遺伝子 / アポトーンス / 自己抗体 / アポトーシス / 関節炎 / 血管炎 / Multienzyme complex involved in fatty acid oxidation / Acyl-CoA oxidase / Polyunsaturated fatty acids / 高度不飽和脂胞酸 / 脂肪酸酸化酵素複合体 / アシル-CoAオキシダーゼ / アシル-CoAシンテターゼ / 高度不飽和脂肪酸 / Small G Protein / 増殖因子 / HDL / VLDL容体 / VLDL受容体 / Rho / SDMF / コレステロール逆転送系 / CETP / M-CSF / リゾフォスファチジルコリン / Background genes / Nephritogenic antibody genes / Arteritis / Autoimmune disease / 腎炎惹起性単クロ-ン抗体 / SCIDマウス / IgG3塩基配列 / 腎炎惹起性単ク-ロン抗体 / 骨炎惹起性抗体遺伝子 / 腎炎惹起性抗体遺伝子 / glioma / acyl-CoA synthetase / Antibody / Acyl-CoA Syntherase / Glioma Less

Calorie Balance,aging and wnt signaling.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Tokuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Tohoku University
Functional identification of a novel endocytic receptorPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Tokuo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Tohoku University
Role of LRP5 in various metabolic pathwaysPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Tokuo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tohoku University
脂肪細胞はいかにして太るか?Principal Investigator
- Principal Investigator
  
  山本徳男
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Wnt signaling in aging related diseasesPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Tokuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Analysis of glomerular lesions in an experimental model induced by apolipoprotein E gene.
- Principal Investigator
  
  SAITO Takao
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  FUKUOKA UNIVERSITY
脂肪酸活性化酵素発現調節による悪性神経膠腫増殖抑制に向けての基礎研究
- Principal Investigator
  
  隈部俊宏
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
リポ蛋白レセプターの構造と機能Principal Investigator
- Principal Investigator
  
  山本徳男
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
CHOLESTEROL METABOLISM IN NEURAL CELLSPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Tokuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
ヒト脳腫瘍に由来するPDGFレセプター変異遺伝子の解析:トランスジェニックマウスによる発症と進展防御に関する研究Principal Investigator
- Principal Investigator
  
  山本徳男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Establishment of murine strains separately with various autoimmune diseases
- Principal Investigator
  
  NOSE Masato
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tohoku University
動脈硬化症の分子生物学的解析と予防・抑制対策に関する総合的研究
- Principal Investigator
  
  北徹
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Developmental Studies on Ultrasensitive Method for Determination of Polyunsaturated Fatty Acids
- Principal Investigator
  
  KAWAGUCHI Akihiko
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo
HIGH MOLECULAR PROTEINS RESPONSIBLE FOR INTRACTABLE INFLAMMATORY DISEASES-IDENTIFICATION AND GENE EXPRESSION-
- Principal Investigator
  
  NOSE Masato
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  TOHOKU UNIVERSITY
動脈硬化・心筋細胞障害成因遺伝子の単離Principal Investigator
- Principal Investigator
  
  山本徳男
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University

All 2014 2012 2011 2009 2007 2004

All Journal Article

[Journal Article] Reelin receptors ApoER2 and VLDLR are expressed in distinct spatio-temporal patterns in developing mouse cerebral cortex.2014
- Author(s)
  Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto TT and Nakajima K
- Journal Title
  
  J. Comp. Neurol
  
  Volume: 523(3) Issue: 3 Pages: 463-78
- DOI
  10.1002/cne.23691
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22111001, KAKENHI-PLANNED-22111004, KAKENHI-PROJECT-24500966, KAKENHI-PROJECT-24700357, KAKENHI-PUBLICLY-25113525, KAKENHI-PUBLICLY-25116522, KAKENHI-PUBLICLY-25123719, KAKENHI-PROJECT-25440114, KAKENHI-PROJECT-26430075, KAKENHI-PROJECT-26830015
[Journal Article] Comparative reactivity of remnant-like lipoprotein particles (RLP)and low-density lipoprotein (LDL)to LDL receptor and VLDL receptor : effect of a high-dose statin on VLDL receptor expression2012
- Author(s)
  Imagawa M, Takahashi S, Zenimaru Y, Kimura T, Suzuki J, Miyamori I, Iwasaki H, Hattori H, Yamamoto TT, Nakano T, Nakajima K
- Journal Title
  
  Clin Chim Acta
  
  Volume: 413巻 Pages: 441-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650177
[Journal Article] Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor : effect of a high-dose statin on VLDL receptor expression2012
- Author(s)
  Imagawa M, Takahashi S, Zenimaru Y, Kimura T, Suzuki J, Miyamori I, Iwasaki T, Hattori H, Yamamoto TT, Nakano T, Nakajima K
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 413 Pages: 441-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650177
[Journal Article] Species differences of macrophage very low-density-lipoprotein(VLDL)receptor protein expression.2011
- Author(s)
  Takahashi S, Ito T, Zenimaru Y, Suzuki J, Miyamori L, Takahashi M, Takahashi M, Ishida T, Ishida T, Hirata KL, Yamamoto TT, Iwasaki T, Hattori H, Shiomi M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 印刷中(未定)
- Data Source
  KAKENHI-PROJECT-22650177
[Journal Article] Species differences of macrophage very low-dansity lipoprotein (VLDL)receptor protein expression2011
- Author(s)
  Takahashi S, Ito T, Zenimaru Y, Suzuki J, Miyamori I, Takahashi M, Ishida T, Ishida T, Hirata K, Yamamoto TT, Iwasaki T, Hattori H, Shiomi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 407巻 Pages: 656-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650177
[Journal Article] Fasting-Induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 22009
- Author(s)
  Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki 0, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sa kai J
- Journal Title
  
  Cell Metabolism 9(2)
  
  Pages: 191-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300227
[Journal Article] Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 22009
- Author(s)
  Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J
- Journal Title
  
  Cell Metab 9(2)
  
  Pages: 191-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300227
[Journal Article] Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.2009
- Author(s)
  Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J.
- Journal Title
  
  Cell Metab 9
  
  Pages: 191-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300227
[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance2007
- Author(s)
  Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y
- Journal Title
  
  Diabetes 56
  
  Pages: 24-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300227
[Journal Article] SOX6 Suppresses Cyclin D1 Promoter Activity by Interacting with β-Ctenin and Histone Deacetylase 1, and Its Down-regulation Induces Pancreatic β-Cell Proliferation.2007
- Author(s)
  Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J
- Journal Title
  
  Journal of Biological Chemistry 282(26)
  
  Pages: 19052-19061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300227
[Journal Article] SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation2007
- Author(s)
  Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 19052-19061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300227
[Journal Article] A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.2004
- Author(s)
  Yamamoto, J. et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 16954-16962
- Data Source
  KAKENHI-PROJECT-16046201
[Journal Article] A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.2004
- Author(s)
  Yamamoto J, et al.
- Journal Title
  
  J Biol Chem.Apr 23 279(17)
  
  Pages: 16954-16962
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390087
[Journal Article] A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.2004
- Author(s)
  Yamamoto J, et al.
- Journal Title
  
  J Biol Chem. 279(17)
  
  Pages: 16954-16962
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390087
[Journal Article] A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.2004
- Author(s)
  Yamamoto, J. et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 16954-16962
- Data Source
  KAKENHI-PROJECT-16390087

1. INAGAKI Yosuke (60400412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NOSE Masato (70030913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KUDOH Toshio (70091684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWAGUCHI Akihiko (80013332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATO Hideki (30142053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NISHIMURA Masahiko (20073661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITO Takao (10125552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UESUGI Noriko (70279264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OIKAWA Shinichi (30142946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 隈部俊宏 (10250747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 北徹 (60161460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 堀内正公 (10117377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山田信博 (40200729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 松沢佑次 (70116101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高井義美 (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 齋藤康 (50101358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. IMAMURA Shigeyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 仲嶋一範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO Tokuo 山本 徳男

山本 徳男 ヤマモト トクオ

Research Projects

Research Products

Co-Researchers

Calorie Balance,aging and wnt signaling.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional identification of a novel endocytic receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of LRP5 in various metabolic pathwaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪細胞はいかにして太るか?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Wnt signaling in aging related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of glomerular lesions in an experimental model induced by apolipoprotein E gene.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪酸活性化酵素発現調節による悪性神経膠腫増殖抑制に向けての基礎研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リポ蛋白レセプターの構造と機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

CHOLESTEROL METABOLISM IN NEURAL CELLSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト脳腫瘍に由来するPDGFレセプター変異遺伝子の解析:トランスジェニックマウスによる発症と進展防御に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Establishment of murine strains separately with various autoimmune diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動脈硬化症の分子生物学的解析と予防・抑制対策に関する総合的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Developmental Studies on Ultrasensitive Method for Determination of Polyunsaturated Fatty Acids

Principal Investigator

Project Period (FY)

Research Category

Research Field

YAMAMOTO Tokuo 山本徳男

山本徳男ヤマモトトクオ