Ohshima Mitsuhiro 大島光宏

… Alternative Names

大島光宏オオシマミツヒロ

OHSHIMA Mitsuhiro 大島光宏

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Researcher Number	30194145
Other IDs
External Links
Affiliation (Current)	2025: 奥羽大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 奥羽大学, 薬学部, 教授 2010 – 2018: 奥羽大学, 薬学部, 教授 2008 – 2009: Nihon University, 歯学部, 専任講師 2003 – 2007: 日本大学, 歯学部, 講師 1998 – 2002: 日本大学, 歯学部, 助手 1992 – 1993: 日本大学, 歯学部, 助手 1992: 日本大学, 歯学部(口腔生化学), 助手
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontology / Pathobiological dentistry/Dental radiology Except Principal Investigator Periodontology / 病態科学系歯学(含放射線系歯学) / Periodontal dentistry / Functional basic dentistry / Basic Section 49010:Pathological biochemistry-related / Pathobiological dentistry/Dental radiology / Periodontal dentistry / Morphological basic dentistry / Natural medicines / Conservative dentistry
Keywords	Principal Investigator 歯周炎 / 生体外歯周炎モデル / 三次元培養 / 線維芽細胞 / FLT1 / miRNA / HGF / integrin / chemotaxis / gingival epithelial cells … More / periodontal ligament fibroblasts / fibronectin / RGD配列 / 歯肉溝滲出液 / Biobank / 上皮細胞走化性 / ラミニン / フィブロネクチン / インテグリン / 走化性 / 歯肉上皮細胞 / 歯根膜線維芽細胞 / フィプロネクチン / コラーゲン分解 / コラーゲン分解阻害剤 / 分子標的治療薬 / 歯周炎原因遺伝子 / コラーゲン分解阻害 / 歯周免疫機能学 / 肝細胞増殖因子 / 歯周炎の病因 / 血小板由来成長因子 / 血小板由来因子(TGF-beta) / 歯肉線維芽細胞 / 細胞外マトリックスの分解 / 歯周組織,歯周炎の病態形成 / 血小板由来因子 … More Except Principal Investigator 3次元培養 / 三次元培養 / サイトカイン / 歯周炎 / mRNA / コラーゲン分解 / 初代培養細胞 / 歯周炎治療薬 / 生体外歯周炎モデル / 初代培養 / マイクロCT / マトリックス金属プロテアーゼ / 遺伝子発現 / amelogenesis / ameloblast / organ culture / in situ hybridization / amelogenin / 細胞増殖 / インプラント周囲炎 / 歯周ポケット / コラゲナーゼインヒビター / コラゲナーゼ / コラーゲン / 歯根膜細胞 / 歯周炎治療 / FLT-1 / カニクイザル / VEGFR阻害剤 / シングルセルRNA-Seq / 歯周炎関連線維芽細胞 / 殺菌 / aPDT / 光 / PCNA / 上皮化 / 創傷治癒促進 / 低出力レーザー治療 / 半導体レーザー / 高繰り返しパルス発振 / 抜歯窩 / 細菌 / 細胞 / LED / レーザー / 上皮細胞 / 初代培養上皮細胞 / HGF / micro CT / chronic arthritis / temporomandibular ioint / 慢性顎関節炎 / 慢性関節炎 / 顎関節 / cytokine / PCR method / Preiodontal Pathogen / Screening / Diagnosis / Periodontal Disease / PCR法 / 歯周病原細菌 / スクリーニング / 診断法 / 歯周病 / tissue inhibitor of matrix metalloprotease / osteoblast-like cells / osteoclastogenesis inhibitory factor / osteoclast differentiation factor / alveolar bone / matrix metalloprotease / high calcium ion concentration / bone remodeling / 細胞外マトリックス成分 / アルカリホスファターゼ / カルシウムイオン / 破骨細胞分化因子 / 骨シアロタンパク質 / 骨芽細胞様細胞 / マトリックス金属プロテアーゼ組織インヒビター / 歯槽骨 / 破骨細胞分化抑制因子 / 高カルシウムイオン濃度 / 骨リモデリング / MATRIX METALLOPROTEINASES / RADICULAR CYST FLUIDS / OSMOTIC PRESSURE / GROWTH FACTORS / CYTOKINES / PROSTANOIDS / RADICULR CYST-DERIVED CELLS / RADICULR CYST EXPANSION / 歯根襄胞由来細胞 / 歯根嚢胞内溶液 / 歯根嚢胞の増大 / 嚢胞内容液 / 浸透圧 / サイトカイン・成長因子 / プロスタノイド / 歯根嚢胞由来細胞 / immunhistochemistry / エナメル質形成 / immunohistochemistry / 浸潤阻害剤 / 口腔癌浸潤モデル / 生薬 / 口腔がん浸潤モデル / 該当なし / 歯肉溝滲出液 / 歯周治療 / 慢性歯周炎 / マイクロストラクチャー / Er:YAGレーザー / a-PDT / 青色LED / チタン / Er:YAG レーザー / 細胞死 / 嚢胞由来線維芽細胞 / 分子標的治療薬 / 角化嚢胞性歯原性腫瘍 / 歯根嚢胞 / 受容体チロシンキナーゼ阻害剤 / 分子標的治療 / 非外科的治療法 / 歯原性嚢胞 / gene expression / TIMP / 細胞培養 / TGF-β Less

A novel trial for periodontitis treatment by administering anti-FLT1 antibody to the naturally-occurred periodontitis-affected cynomolgus monkey gingiva
- Principal Investigator
  
  山口洋子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nihon University
Development of a novel drug for periodontitis based on the characteristics of gingival epithelial cells
- Principal Investigator
  
  YAMAGUCHI Yoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Nihon University
Development of molecular targeted drug for periodontitis based on the causative genes.Principal Investigator
- Principal Investigator
  
  Mitsuhiro Ohshima
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Ohu University
Development of molecular targeted drugs for oral cancer cell invasion using herbal end products
- Principal Investigator
  
  YAMAGUCHI Yoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Nihon University
Development of phototherapy using lasers and LEDs for the treatment and prevention of periodontitis and peri-implantitis
- Principal Investigator
  
  AOKI AKIRA
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Tokyo Medical and Dental University
Healing response to initial periodontal therapy based on GCF profiling
- Principal Investigator
  
  NAKASHIMA KEISUKE
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Kyushu Dental College
Development of innovative treatment methods using light energy for periodontitis and peri-implantitis
- Principal Investigator
  
  AOKI Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Tokyo Medical and Dental University
A basic research to establish molecular targeted therapy for odontogenic cysts
- Principal Investigator
  
  YAMAGUCHI Yoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nihon University
Establishment of an effective three dimensional culture model for screening of molecular targeted drug for periodontitisPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Mitsuhiro
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Ohu University
  Nihon University
The roles of platelet-derived factors in periodontal tissuePrincipal Investigator
- Principal Investigator
  
  OHSHIMA Mitsuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Nihon University
The duration analysis of the experimental rabbit temporomandibular joint inflammation by the X ray in vivo micro CT for high-speed high resolution animals
- Principal Investigator
  
  HONDA Kazuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Nihon University
Fibronectin participates in the initiation of periodontitisPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Mitsuhiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Nihon University
General study of development of periodontal disease examination
- Principal Investigator
  
  KAWAGUCHI Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontal dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Dynamic phase of Alveolar Bone-derived Osteoblasts at High Calcium Ion Concentration with Bone Resorption Accentuation.
- Principal Investigator
  
  MAENO Masao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Nihon-University
A STUDY ON THE MECHANISM OF RADICULAR CYST EXPANSION USING RADICULAR CYST-DERIVED CELLS
- Principal Investigator
  
  OTUKA Kichibee
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  NIHON UNIVERSITY
ヒト歯根膜細胞のコラーゲン,コラゲナーゼおよびTIMP遺伝子の発現
- Principal Investigator
  
  桑田文幸
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nihon University
培養ヒト歯根膜細胞のコラーゲン代謝について
- Principal Investigator
  
  KUWATA Fumiyuki
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nihon University
Gene Expression and Distribution of Amelogenin during Amelogenesis
- Principal Investigator
  
  INAGE Toshihiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nihon University, School of Dentistry

[Book] 最新　動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術2014
- Author(s)
  山口洋子、大島光宏、佐久間淳
- Total Pages
  584
- Publisher
  株式会社技術協会
- Data Source
  KAKENHI-PROJECT-25460137
[Journal Article] Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis.2021
- Author(s)
  Yamaguchi Y, Saito A, Horie M, Aoki A, Micke P, Ohshima M, Kappert K
- Journal Title
  
  Odontology
  
  Volume: 109 Issue: 4 Pages: 912-920
- DOI
  10.1007/s10266-021-00625-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07344, KAKENHI-PROJECT-20K09971
[Journal Article] Local administration of anti-hepatocyte growth factor-neutralizing antibody reverts naturally occurring periodontitis2021
- Author(s)
  Yamaguchi Y, Ohshima M
- Journal Title
  
  J oral biosci
  
  Volume: 63 Issue: 3 Pages: 245-252
- DOI
  10.1016/j.job.2021.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07344
[Journal Article] TBX4 is involved in the super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts.2018
- Author(s)
  Horie M, Miyashita N, Mikami Y, Noguchi S, Yamauchi Y, Suzukawa M, Fukami T, Ohta K, Asano Y, Sato S, Yamaguchi Y, Ohshima M, Suzuki HI, Saito A, Nagase T.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 314 Issue: 1 Pages: L177-L191
- DOI
  10.1152/ajplung.00193.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02653, KAKENHI-PROJECT-16K11843, KAKENHI-PROJECT-17K09629
[Journal Article] Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC2017
- Author(s)
  Horie M, Kaczkowski B, Ohshima M, Matsuzaki H, Noguchi S, Mikami Y, Lizio M, Itoh M, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest ARR, Takai D, Yamaguchi Y, Micke P, Saito A, Nagase T.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 15 Issue: 10 Pages: 1354-1365
- DOI
  10.1158/1541-7786.mcr-17-0191
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11843, KAKENHI-PROJECT-17K16042, KAKENHI-PROJECT-17K18366, KAKENHI-PROJECT-16H02653
[Journal Article] MicroRNA profiling in gingival crevicular fluid of periodontitis: a pilot study2017
- Author(s)
  Akira Saito, Masafumi Horie, Kenichiro Ejiri, Akira Aoki, Sayaka Katagiri, Shogo Maekawa, Shinta Suzuki, Sophannary Kong, Tsuneto Yamauchi, Yoko Yamaguchi, Yuichi Izumi, Mitsuhiro Ohshima
- Journal Title
  
  FEBS Open Bio
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15768
[Journal Article] MicroRNA profiling in gingival crevicular fluid of periodontitis-a pilot study2017
- Author(s)
  Saito Akira、Horie Masafumi、Ejiri Kenichiro、Aoki Akira、Katagiri Sayaka、Maekawa Shogo、Suzuki Shinta、Kong Sophannary、Yamauchi Tsuneto、Yamaguchi Yoko、Izumi Yuichi、Ohshima Mitsuhiro
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 7 Pages: 981-994
- DOI
  10.1002/2211-5463.12238
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11825, KAKENHI-PROJECT-16K11843
[Journal Article] Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis2016
- Author(s)
  Ohshima M, Yamaguchi Y, Ambe K, Horie M, Saito A, Nagase T, Nakashima K, Ohki H, Kawai T, Abiko Y, Micke P, Kappert K
- Journal Title
  
  J Clin Periodontol
  
  Volume: 43(2) Issue: 2 Pages: 128-37
- DOI
  10.1111/jcpe.12495
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461185, KAKENHI-PROJECT-15K15768
[Journal Article] Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis2016
- Author(s)
  Ohshima M, Yamaguchi Y, Ambe K, Horie M, Saito A, Nagase T, Nakashima K, Ohki H, Kawai T, Abico Y, Micke P, Kappert K
- Journal Title
  
  J Clin Periondontol
  
  Volume: 43 Issue: S20 Pages: 128-137
- DOI
  10.1111/jcpe.12945
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460137
[Journal Article] Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis.2016
- Author(s)
  Horie M, Yamaguchi Y, Saito A, Nagase T, Lizio M, Itoh M, Kawaji H, Lassmann T, Carninci P, Forrest AR, Hayashizaki Y, Suzutani T, Kappert K, Micke P, Ohshima M.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1
- DOI
  10.1038/srep33666
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02653, KAKENHI-PROJECT-26461185, KAKENHI-PROJECT-15K15768, KAKENHI-PROJECT-16K11843
[Journal Article] Three-dimensional Co-culture Model for Tumor-stromal Interaction2015
- Author(s)
  Horie M, Saito A, Yamaguchi Y, Ohshima M, Nagase T
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 96 Issue: 96
- DOI
  10.3791/52469
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460137, KAKENHI-PROJECT-26461185
[Journal Article] Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer.2014
- Author(s)
  6.Horie M, Saito A, Noguchi S, Yamaguchi Y, Ohshima M, Morishita Y, Suzuki HI, Kohyama T, Nagase T.
- Journal Title
  
  BMC Cancer.
  
  Volume: 14 Issue: 1 Pages: 580-580
- DOI
  10.1186/1471-2407-14-580
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-25460137, KAKENHI-PROJECT-26461185
[Journal Article] 新しい歯周炎の見方と多因子性疾患発症のBINGOモデル仮説2014
- Author(s)
  大島光宏、山口洋子
- Journal Title
  
  医薬品相互作用研究
  
  Volume: 38 Pages: 82-88
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460137
[Journal Article] 歯周炎薬物治療のパラダイムシフト（総説）2013
- Author(s)
  大島光宏
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by microRNAs in lung cancer cells2013
- Author(s)
  Akira Saito, Hiroshi I Iizuka, Masafumi Horie, Mitsuhiro Ohshima, Yasuyuki Morishita, Yoshimitsu Abiko, Takahide Nagase
- Journal Title
  
  PLoS ONE 8
  
  Volume: 8 Issue: 1 Pages: 158-163
- DOI
  10.1016/j.bbrc.2012.05.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637, KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-23790899
[Journal Article] 歯周炎薬物治療のパラダイムシフト(総説)2013
- Author(s)
  大島光宏、山口洋子
- Journal Title
  
  日薬理誌
  
  Volume: 141 Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] High-frequency low-level diode laser irradiation promotes proliferation and migration of primary cultured human gingival epithelial cells2013
- Author(s)
  Kenichiro Ejiri, Akira Aoki, Yoko Yamaguchi, Mitsuhiro Ohshima, Yuichi Izumi
- Journal Title
  
  Lasers Med Sci 2013
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] High-frequency low-level diode laser irradiation promotes proliferation and migration of primary cultured human gingival epithelial cells2013
- Author(s)
  Kenichiro Ejiri
- Journal Title
  
  Lasers Med Sci
  
  Volume: 未定 Issue: 4 Pages: 1339-1347
- DOI
  10.1007/s10103-013-1292-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637, KAKENHI-PROJECT-25463212
[Journal Article] Characterization of human lung cancer-associated fibroblasts in three dimensional in vitro co-culture model2012
- Author(s)
  Masafumi Horie, Akira Saito, Mitsuhiro Ohshima, Yasuyuki Morishita, Jun Nakajima, Tadashi Kohyama, Takahide Nagase
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 423 Issue: 2 Pages: 158-163
- DOI
  10.1371/journal.pone.0056587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637, KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-23790899, KAKENHI-PROJECT-24689018, KAKENHI-PUBLICLY-23112702
[Journal Article] Insulin-like growth factor-binding protein-2 and -3 in gingival crevicular fluid2010
- Author(s)
  Y.Takenouchi, M.Ohshima, ほか
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 45 Pages: 803-808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] TGF-β signaling in gingival-epithelial interaction2010
- Author(s)
  M.Ohshima, Y.Yamaguchi, ほか
- Journal Title
  
  Journal of Dental Research
  
  Volume: 89 Pages: 1315-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] TGF-β signaling in gingival fibroblast-epithelial interaction2010
- Author(s)
  M.Ohshima, Y.Yamaguchi, ほか
- Journal Title
  
  Journal of Dental Research
  
  Volume: 89 Pages: 1315-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592433
[Journal Article] Insulin-like growth factor binding proteins(IGFBP)-2,-3 in gingival crevicular fluid2010
- Author(s)
  Takenouchi Y, Ohshima M, Yamaguchi Y, Nishida T, Senda N, Idesawa M, Otsuka K, Ito K
- Journal Title
  
  J Periodontal Res
  
  Volume: 45 Pages: 803-808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592433
[Journal Article] TGF-beta Signaling in Gingival Fibroblast-Epithelial Interaction2010
- Author(s)
  M. Ohshima, Y. Yamaguchi, N. Matsumoto, P. Micke, Y. Takenouchi, T. Nishida, M. Kato, K. Komiyama, Y. Abiko, K. Ito, K. Otsuka, K. Kappert
- Journal Title
  
  J Dent Res
  
  Volume: 89 Pages: 1315-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592433
[Journal Article] Insulin-like growth factor-binding protein-2 and -3 in gingival crevicular fluid2010
- Author(s)
  Takenouchi Y, Ohshima M, Yamaguchi Y, Nishida T, Senda N, Idesawa M, Otsuka K, Ito K
- Journal Title
  
  J Periodontal Res
  
  Volume: 45 Issue: 6 Pages: 803-808
- DOI
  10.1111/j.1600-0765.2010.01309.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] TGF-b signaling in gingival fibroblast-epithelial interaction2010
- Author(s)
  M. Ohshima, Y. Yamaguchi, M. Matsumoto, P. Micke, T. Takenouchi, N. Nishida, M. Kato, K. Komiyama, Y. Abiko, K. Ito, K. Otsuka, K. Kappert
- Journal Title
  
  J Dent Res
  
  Volume: 89 Issue: 11 Pages: 1315-1321
- DOI
  10.1177/0022034510378423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592637
[Journal Article] bFGF rescues imatinib/STI571-induced apoptosis of sis-NIH3T3 fibroblasts2009
- Author(s)
  Ohshima M, Yamaguchi Y, Kappert K, Micke P, Otsuka K
- Journal Title
  
  Biochem Biophys Res Commun 381
  
  Pages: 165-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592395
[Journal Article] In vitro characterization of the cytokine profile ofthe epithelial cell rests of Malassez2008
- Author(s)
  Ohshima M, Yamaguchi Y, Micke P, Abiko Y, Otsuka K
- Journal Title
  
  J Periodontol 79
  
  Pages: 912-919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592395
[Journal Article] Profiling of radicular cyst and odontogenic keratocyst cytokine production suggests common growth mechanisms2008
- Author(s)
  Hayashi M, Ohshima T, Ohshima M, Yamaguchi Y, Miyata H, Takeichi O, Ogiso B, Ito K, Ostman A, Otsuka K
- Journal Title
  
  J Endod 34
  
  Pages: 14-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592395
[Journal Article] In vitro characteri- zation of the cytokine profile of the epithelial cells of rests of Malassez2008
- Author(s)
  Ohshima M, Yamaguchi Y, Micke P, Abiko Y, Otsuka K
- Journal Title
  
  J Periodontol 79
  
  Pages: 912-919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592395
[Journal Article] Biobanking of fresh frozen tissue : RNA is stable in non-fixed surgical specimens.2006
- Author(s)
  Micke P, Ohshima M, et al.
- Journal Title
  
  Laboratory Investigation 86(2)
  
  Pages: 202-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15592004
[Journal Article] Biobanking of fresh frozen tissue : RNA is stable in non-fixed surgical specimens.2006
- Author(s)
  Micke P, Ohshima M, et al.
- Journal Title
  
  Laboratory Investigation 86・2
  
  Pages: 202-211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15592004
[Journal Article] Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array.2006
- Author(s)
  Sakai S, Ohshima M, et al.
- Journal Title
  
  Journal of Periodontology 77(5)
  
  Pages: 856-864
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15592004
[Journal Article] Periodontal ligament fibroblasts produce laminin and fibronectin as potent chemoattractants for gingival epithelial cells.2005
- Author(s)
  Ohshima M, Yamaguchi Y, Otsuka K
- Journal Title
  
  International Congress Series 1284
  
  Pages: 215-216
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15592004
[Journal Article] Periodontal ligament fibroblasts produce laminin and fibronectin as potent chemoattractant for gingival epithelial cells2005
- Author(s)
  Ohshima M, Yamaguchi Y, Kichibee Otsuka
- Journal Title
  
  International Congress Series 1284
  
  Pages: 215-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15592004
[Journal Article] Periodontal ligament fibroblasts produce laminin and fibronectin as potent chemoattractants for gingival epithelial cells2005
- Author(s)
  Mitsuhiro Ohshima et al.
- Journal Title
  
  International Congress Series 1284
  
  Pages: 215-216
- Data Source
  KAKENHI-PROJECT-15592004
[Patent] 歯周炎の予防、改善、及び治療用組成物2021
- Inventor(s)
  山口洋子、大島光宏、深田一剛、巽一憲
- Industrial Property Rights Holder
  山口洋子、大島光宏、深田一剛、巽一憲
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-073776
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K07344
[Patent] 歯周炎の予防、改善、及び治療用組成物2020
- Inventor(s)
  山口洋子、大島光宏、深田一剛、巽一憲
- Industrial Property Rights Holder
  山口洋子、大島光宏、深田一剛、巽一憲
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-079910
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07344
[Patent] 屈折点による病変探知2018
- Inventor(s)
  山内恒人、大島光宏，山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-148587
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K11843
[Patent] インプラント周囲炎の予防、及び／又は治療に使用する物質のスクリーニング方法、及びインプラント周囲炎の予防用、及び／又は治療用組成物2018
- Inventor(s)
  山口洋子、大島光宏、深田一剛，巽一憲
- Industrial Property Rights Holder
  日本大学、ロート製薬
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-202631
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K11843
[Patent] 歯周炎治療薬および歯周炎治療組成物2017
- Inventor(s)
  大島光宏、山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K11843
[Patent] 歯周炎治療薬2017
- Inventor(s)
  大島光宏、山口洋子、齋藤朗、堀江真史、長瀬隆英
- Industrial Property Rights Holder
  日本大学、東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-101501
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K11843
[Patent] miRNAをマーカーつする歯周炎検査キット、および検査方法2017
- Inventor(s)
  大島光宏、山口洋子、齋藤朗、堀江真史、長瀬隆英、岩本久美
- Industrial Property Rights Holder
  日本大学、東京大学、株式会社アイシーエレクトロニクス
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K11843
[Patent] 歯周炎原因細胞の特定方法、歯周炎治療薬のスクリーニング方法、歯周炎の検査方法、検査キット2016
- Inventor(s)
  大島光宏、山口洋子、堀江真史、齋藤朗、長瀬隆英、岩本久美
- Industrial Property Rights Holder
  大島光宏、山口洋子、堀江真史、齋藤朗、長瀬隆英、岩本久美
- Industrial Property Rights Type
  特許
- Filing Date
  2016-03-10
- Overseas
- Data Source
  KAKENHI-PROJECT-25460137
[Patent] 歯周病検査キット、および検査方法2016
- Inventor(s)
  大島光宏、山口洋子、岩本久美、神谷正巳
- Industrial Property Rights Holder
  大島光宏、山口洋子、岩本久美、神谷正巳
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-049214
- Filing Date
  2016-03-14
- Data Source
  KAKENHI-PROJECT-25460137
[Patent] 歯周炎治療薬及び歯周炎治療用組成物2016
- Inventor(s)
  大島光宏、山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-146593
- Filing Date
  2016-07-26
- Data Source
  KAKENHI-PROJECT-15K15768
[Patent] 歯周炎治療薬及び歯周炎治療用組成物2016
- Inventor(s)
  山口洋子、大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-146593
- Filing Date
  2016-07-26
- Data Source
  KAKENHI-PROJECT-16K11843
[Patent] 歯周炎原因細胞の特定方法、歯周炎治療薬のスクリーニング方法、歯周炎の検査方法、検査キット2015
- Inventor(s)
  大島光宏、山口洋子、堀江真史、齋藤朗、長瀬隆英、岩本久美
- Industrial Property Rights Holder
  株式会社アイシーエレクトロニクス、日本大学、東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-060644
- Filing Date
  2015-03-24
- Data Source
  KAKENHI-PROJECT-25460137
[Patent] 歯周炎治療薬2012
- Inventor(s)
  山口洋子、大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2012-086327
- Filing Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 歯周炎治療薬2012
- Inventor(s)
  山口洋子，大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-086327
- Filing Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 歯周炎治療薬2012
- Inventor(s)
  大島光宏、山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2012-086327
- Filing Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 口腔癌細胞浸潤阻害剤2011
- Inventor(s)
  山口洋子、大島光宏、鳥居塚和生
- Industrial Property Rights Holder
  日本大学,昭和大学
- Industrial Property Number
  2011-220423
- Filing Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] 口腔癌細胞浸潤阻害剤2011
- Inventor(s)
  大島光宏、山口洋子、鳥居塚和生
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2011-220423
- Filing Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 口腔癌細胞浸潤阻害剤2011
- Inventor(s)
  山口洋子、大島光宏、鳥居塚和生
- Industrial Property Rights Holder
  日本大学、昭和大学
- Industrial Property Number
  2011-220423
- Filing Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 歯周炎治療薬2010
- Inventor(s)
  大島光宏, 山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2010-024339
- Filing Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] コラーゲン分解阻害剤2010
- Inventor(s)
  大島光宏, 山口洋子, 鳥居塚和生
- Industrial Property Rights Holder
  日本大学昭和大学
- Industrial Property Number
  2010-132206
- Filing Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 顎.胞治療薬2010
- Inventor(s)
  山口洋子、大島光宏、大木秀郎
- Industrial Property Rights Holder
  日本大学
- Patent Publication Number
  2012-012365
- Filing Date
  2010-07-05
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] 特許権2010
- Inventor(s)
  大島光宏, ほか2名
- Industrial Property Rights Holder
  日本大学昭和大学
- Industrial Property Number
  2010-132206
- Filing Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] 歯周炎治療薬2010
- Inventor(s)
  大島光宏、山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2010-024339
- Filing Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] コラーゲン分解阻害剤2010
- Inventor(s)
  山口洋子、大島光宏、鳥居塚和生
- Industrial Property Rights Holder
  日本大学,昭和大学
- Patent Publication Number
  2011-256136
- Filing Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] 顎嚢胞治療剤2010
- Inventor(s)
  山口洋子、大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2010-152872
- Filing Date
  2010-07-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] コラーゲン分解阻害剤2010
- Inventor(s)
  大島光宏、山口洋子、鳥居塚和生
- Industrial Property Rights Holder
  日本大学、昭和大学
- Industrial Property Number
  2010-132206
- Filing Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 歯周炎治療薬2010
- Inventor(s)
  大島光宏, 山口洋子
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2010-024339
- Filing Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 生体外創傷治癒試験用用具または創傷作製方法2009
- Inventor(s)
  山口洋子, 大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-212903
- Filing Date
  2009-09-15
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 歯肉上皮細胞の培養方法2009
- Inventor(s)
  山口洋子、大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-231339
- Filing Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 歯肉上皮細胞の培養方法2009
- Inventor(s)
  山口洋子, 大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-231339
- Filing Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 特許2009
- Inventor(s)
  大島光宏, 山口洋子, 松本直行, 加藤光保
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-072185
- Filing Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-19592395
[Patent] 歯肉上皮細胞の培養方法2009
- Inventor(s)
  山口洋子, 大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-231339
- Filing Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] 生体外創傷治癒試験用用具または創傷作製方法2009
- Inventor(s)
  山口洋子、大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-212903
- Filing Date
  2009-09-15
- Data Source
  KAKENHI-PROJECT-21592637
[Patent] 生体外創傷治癒試験用用具または創傷作成方法2009
- Inventor(s)
  山口洋子, 大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2009-212903
- Filing Date
  2009-09-15
- Data Source
  KAKENHI-PROJECT-21592433
[Patent] 特許2009
- Inventor(s)
  大島光宏,山口洋子,松本直行,加藤光保
- Industrial Property Rights Holder
  日本大学
- Filing Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-19592395
[Patent] 特許2008
- Inventor(s)
  大島光宏
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2008-261265
- Filing Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-19592395
[Patent] 特許2008
- Inventor(s)
  大島光宏
- Industrial Property Rights Holder
  日本大学
- Filing Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-19592395
[Presentation] 歯周炎のプレシジョン・メディシンに向けて2020
- Author(s)
  大島光宏
- Organizer
  第63回春季日本歯周病学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07344
[Presentation] 漢方薬成分のインプラント周囲炎治療薬候補としての可能性2020
- Author(s)
  山口洋子, 深田　一剛, 巽　一憲, 青木　章, 大島光宏
- Organizer
  第35回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-20K07344
[Presentation] 屈折点による病変探索2018
- Author(s)
  山口洋子, 山内恒人, 大島光宏, 小西一典, 中野　茂
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] 糖尿病患者と非糖尿病患者の洗口吐出液中HGFとヘモグロビンによる歯周炎診断の有用性について2018
- Author(s)
  大島光宏，山内恒人，山口洋子，小西一典，衛藤雅昭，中野茂
- Organizer
  第33回糖尿病合併症学会・第24回日本糖尿病眼科学会総会
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] 糖尿病と歯周病：石川県羽咋郡市中野プロジェクト（その１）2018
- Author(s)
  山内恒人，大島光宏，山口洋子，小西一典，衛藤雅昭，中野　茂
- Organizer
  第71回東北地区歯科医学会
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] 屈折点による病変探索2018
- Author(s)
  山内恒人，山口洋子，大島光宏，小西一典，中野茂
- Organizer
  第33回糖尿病合併症学会・第24回日本糖尿病眼科学会総会
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] Targeting hepatocyte growth factor as novel therapeutic approach for periodontitis2018
- Author(s)
  Yamaguchi Y, Ohshima M
- Organizer
  EuroPerio9
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] 糖尿病患者の洗口吐出液中HGF量とヘモグロビン量との関係について,2018
- Author(s)
  大島光宏, 山内恒人, 山口洋子, 小西一典, 衛藤雅昭, 中野　茂
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] MicroRNA profiling in gingival crevicular fluid of periodontitis patients.2018
- Author(s)
  Ohshima M, A. Saito, Horie M, Ejiri K, Aoki A, Katagiri S, Maekawa S, Suzuki S, Kong S, Yamauchi T, Yamaguchi Y, Izumi Y
- Organizer
  EuroPerio9
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11843
[Presentation] 歯肉溝滲出液miRNA による新しい歯周炎診断法2016
- Author(s)
  齋藤朗, 堀江真史, 江尻健一郎, 青木章, 鈴木伸太, 前川省吾, 片桐さやか, Sophannary Kong, 山内恒人, 山口洋子, 和泉雄一, 大島光宏
- Organizer
  東北地区歯科医学会
- Place of Presentation
  宮城県歯科医師会館（宮城県仙台市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K15768
[Presentation] CAGE revealed novel biomarker of periodontitis-associated fibroblasts2015
- Author(s)
  Masafumi Horie, Yoko Yamaguchi, Akira Saito, Takahide Nagase, Masayoshi Itoh , Hideya Kawaji, Timo Lassmann, Piero Carninci, Yoshihide Hayashizaki, Alistair Forrest, The FANTOM consortium, Marina Lizio, Masahiro Kondo, Tatsuo Suzutani, Patrick Micke, and Mitsuhiro Ohshima
- Organizer
  IMGC2015
- Place of Presentation
  横浜市
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15768
[Presentation] がん浸潤に関与する遺伝子発現のプロファイリング2015
- Author(s)
  山口洋子、石井輝彦、大木秀郎、堀江真史、大島光宏、 Patrick Micke
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460137
[Presentation] CAGE revealed novel biomarker of periodontitis - associated fibroblast.2015
- Author(s)
  Horie M, Yamaguchi Y, Saito A, Nagase T, Itoh M, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest A, The FANTOM consortium, Lizio M, Kondo M, Suzutani T, Micke P, Ohshima M
- Organizer
  29th IMGC
- Place of Presentation
  横浜市開港記念会館（神奈川県横浜市）
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460137
[Presentation] Super-pulsed low-level diode Laser stimulates cultured human gingival epithelial cells2013
- Author(s)
  Kenichiro Ejiri, Akira Aoki, Yoko Yamaguchi,Mitsuhiro Ohshima, Yuichi Izumi
- Organizer
  91^<st>IADR
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 低出力半導体レーザー照射が初代培養ヒト歯肉上皮細胞に及ぼす効果2012
- Author(s)
  江尻健一郎、青木章、山口洋子、大島光宏、和泉雄一
- Organizer
  第24回日本レーザー歯学会総会・学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation]2012
- Author(s)
  大島光宏、山口洋子、張月琳、佐久間淳
- Organizer
  2012年度日本機会学会年次大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 低出力半導体レーザー照射が培養ヒト歯肉上皮細胞に及ぼす効果2012
- Author(s)
  江尻健一郎、青木章、山口洋子、大島光宏、和泉雄一
- Organizer
  第136回日本歯科保存学会春季学術大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] FLT-1は歯周炎治療の標的分子となり得るか2012
- Author(s)
  大島光宏、山口洋子、安孫子宜光
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  郡山
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 受容体チロシンキナーゼ阻害剤による非外科的顎嚢胞治療法の開発2011
- Author(s)
  山口洋子, 大島光宏
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会議場(京都府)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] FLT-1 represents a potential therapeutic target in human periodontitis2011
- Author(s)
  Mitsuhiro Ohshima, Yoko Yamaguchi, Yoshimitsu Abiko
- Organizer
  GRC in Periodontal Diseases
- Place of Presentation
  Davidson College, Davidson, NC, USA
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 受容体チロシンキナーゼ阻害剤による非外科的顎〓胞治療法の開発2011
- Author(s)
  大島光宏、山口洋子、石井輝彦、大木秀郎
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] FLT-1 represents a potential therapeutic target in human periodontitis. Gordon Research Conference in Periodontal Diseases2011
- Author(s)
  Mitsuhiro Ohshima, Yoko Yamaguchi, Yoshimitsu Abiko
- Organizer
  Davidson College
- Place of Presentation
  Davidson, NC, USA
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] FLT-1 represents a potential therapiutic target in human periodontitis2011
- Author(s)
  Ohshima M, Yamaguchi Y, Abiko Y
- Organizer
  Gordon Research Conference in Periodontal Diseases
- Place of Presentation
  Davidson College, Davidson, NC
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 受容体チロシンキナーゼ阻害薬による非外科的顎.胞治療法の開発2011
- Author(s)
  大島光宏、山口洋子、石井輝彦、大木秀郎
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会議場、京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] 三次元培養法を用いた新規歯周炎治療薬のスクリーニング2010
- Author(s)
  山口洋子, 大島光宏
- Organizer
  第42回日本結合組織学会、第57回マトリックス研究会合同学術集会
- Place of Presentation
  秋田拠点センター・アルヴェ
- Year and Date
  2010-08-19
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 3次元培養法を用いた新規歯周炎治療薬のスクリーニング2010
- Author(s)
  山口洋子、大島光宏
- Organizer
  第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
- Place of Presentation
  秋田拠点セン拠点センター、秋田
- Year and Date
  2010-08-19
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] 生薬による生体外歯周炎モデルのコラーゲン分解阻害2010
- Author(s)
  山口洋子, 鳥居塚和生, 大島光宏
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  奥羽大学(郡山)
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] A novel drug screening system for periodontitis using 3D culture2010
- Author(s)
  Ohshima M, Yamaguchi Y, Abiko Y
- Organizer
  GRC in Periodontal Diseases
- Place of Presentation
  Colby-Sawyer College, New London, NH, USA
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 生体外歯周炎モデルによる生薬のスクリーニング2010
- Author(s)
  山口洋子、鳥居塚和生、大島光宏
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 三次元培養法を用いた新規歯周炎治療薬のスクリーニング2010
- Author(s)
  山口洋子、大島光宏
- Organizer
  第42回日本結合組織学会・第57回マトリックス研究会合同学術集会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 生体外歯周炎モデルによる生薬のスクリーニング2010
- Author(s)
  山口洋子、鳥居塚和生、大島光宏
- Organizer
  第33回分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場、兵庫
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] 生薬による生体外歯周炎モデルのコラーゲン分解阻害薬2010
- Author(s)
  山口洋子、鳥居塚和生、大島光宏
- Organizer
  日本薬学会東北支部
- Place of Presentation
  奥羽大学、福島
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] 生薬による生体外歯周炎モデルのコラーゲン分解阻害2010
- Author(s)
  山口洋子、鳥居塚和生、大島光宏
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  郡山
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] Screening of finished herbal products using in vitro periodontitis model2010
- Author(s)
  Y.Yamaguchi, K.Toriizuka, M.Ohshima
- Organizer
  BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] A novel drug screening system for periodontitis using 3D culture2009
- Author(s)
  Mitsuhiro Ohshima, Yoko Yamaguchi, Naoyuki Matsumoto, Yuka Takenouchi, Tetsuya Nishida, Mitsuyasu Kato, Kazuo Komiyama, Yoshimitsu Abiko, Koichi Ito, Kichibee Otsuka
- Organizer
  Europerio 6
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] TGF-beta signaling in aggressive matrix destruction by gingival fibroblasts2009
- Author(s)
  Mitsuhiro Ohshima, Yoko Yamaguchi, Naoyuki Matsumoto, Patrick Micke, Yuka Takenouchi, Tetsuya Nishida, Mitsuyasu Kato, Kazuo Komiyama, Yoshimitsu Abiko, Koichi Ito, Kichibee Otsuka, Kai Kappert
- Organizer
  TGF-beta meeting in Uppsala
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] A novel drug screening system for periodontitis using three-dimensional culture2009
- Author(s)
  Mitsuhiro Ohshima, Yoko Yamaguchi, Naoyuki Matsumoto, Yuka Takenouchi, Tetsuya Nishida, Mitsuyasu Kato, Kazuo Komiyama, Yoshimitsu Abiko, Koichi Ito, Kichibee Otsuka
- Organizer
  Gordon Research Conference in Periodontal Diseases, Colby-Sawyer College
- Place of Presentation
  New London, NH, USA
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-21592433
[Presentation] A novel drug screening system for periodontitis using 3D culture2009
- Author(s)
  Ohshima M
- Organizer
  歯周病ゴードン会議
- Place of Presentation
  Colby-Sawyer College, New London, NH,(USA)
- Year and Date
  2009-08-05
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 三次元培養法による歯周炎モデルの試作,第31回日本分子生物学会2008
- Author(s)
  大島光宏
- Organizer
  第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19592395
[Presentation] 三次元培養法を用いた歯周炎モデルの開発2008
- Author(s)
  大島光宏
- Organizer
  第51回秋季日本歯周病学会学術大会
- Place of Presentation
  四日市
- Year and Date
  2008-10-19
- Data Source
  KAKENHI-PROJECT-19592395
[Presentation] 三次元培養法による歯周炎モデルの試作2008
- Author(s)
  大島光宏, 山口洋子, 松本直行, 加藤光保, ほか
- Organizer
  第31回日本分子生物学会年会, 第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19592395
[Presentation] 歯周炎和漢薬物療法のパラダイムシフト
- Author(s)
  大島光宏、山口洋子、鳥居塚和生
- Organizer
  和漢医薬学会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2014-08-30 – 2014-08-31
- Invited
- Data Source
  KAKENHI-PROJECT-25460137
[Presentation] 歯周炎治療薬候補のスクリーニングにおける押し込み試験の有用性
- Author(s)
  大島光宏
- Organizer
  2012年度日本機械学会年次大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] がん浸潤モデルを用いた浸潤阻害剤の検討
- Author(s)
  山口洋子、福村基徳、石井輝彦、大木秀郎、鳥居塚和生、大島光宏
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460137
[Presentation] FLT-1は歯周炎治療の標的分子となり得るか
- Author(s)
  大島光宏
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  郡山
- Data Source
  KAKENHI-PROJECT-21592637
[Presentation] 生薬が担う歯周炎薬物療法のパラダイムシフト
- Author(s)
  大島光宏、山口洋子、鳥居塚和生
- Organizer
  医療薬学フォーラム2014
- Place of Presentation
  ビッグサイト（東京都江東区）
- Year and Date
  2014-06-28 – 2014-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-25460137

1. YAMAGUCHI Yoko (00239922)

# of Collaborated Projects: 9 results

# of Collaborated Products: 63 results
2. OTSUKA Kichibee (50059995)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. ABIKO Yoshimitsu (70050086)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
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# of Collaborated Projects: 3 results

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# of Collaborated Projects: 2 results

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# of Collaborated Projects: 2 results

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7. AOKI Akira (30302889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. KOBAYASHI Hiroaki (50396967)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKEUCHI Yasuo (60396968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. AKIZUKI Tatsuya (50401378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MIZUTANI Koji (60451910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. KOMAKI Motohiro (30401368)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. IWASAKI Kengo (40401351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. TANIGUCHI Yoichi (30648093)

# of Collaborated Projects: 2 results

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# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 齋藤朗 (90591412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
17. SCHWARZ Frank

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. SCULEAN Anton

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. ICHINOSE Shizuko (60014156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NAKASHIMA KEISUKE (80227785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TORIZUKA Kazuo (60135035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. TODA Yoshihisa (20059413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SHIMOKAWA Hitoyata (80014257)

# of Collaborated Projects: 1 results

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24. TSURUMACHI Tamotsu (60139201)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SUZUKI Naoto (10226532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. ITO Koich (90102607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ITO Emi (90297838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KAWAGUCHI Hiroyuki (10224750)

# of Collaborated Projects: 1 results

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30. UMEDA Makoto (90193937)

# of Collaborated Projects: 1 results

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31. KAWABATA Yoshikatsu (80329490)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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33. HONDA Kazuya (30199567)

# of Collaborated Projects: 1 results

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34. ARAI Yoshinori (20212607)

# of Collaborated Projects: 1 results

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35. ASANO Masatake (10231896)

# of Collaborated Projects: 1 results

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36. KAWASHIMA Shoji (30349964)

# of Collaborated Projects: 1 results

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37. EJIMA Ken-ichiro (50267093)

# of Collaborated Projects: 1 results

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38. Tsuchida Sachio (90410422)

# of Collaborated Projects: 1 results

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39. 山海直 (80300937)

# of Collaborated Projects: 1 results

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40. SAWABE Masanori

# of Collaborated Projects: 1 results

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41. EJIRI Kenichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. OGITA Mayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. SATO Ikufumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. TSUBOKAWA Masaki

# of Collaborated Projects: 1 results

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45. HORIE Masafumi

# of Collaborated Projects: 1 results

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46. EDUARD Carlos

# of Collaborated Projects: 1 results

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47. ALEKSIC Verica

# of Collaborated Projects: 1 results

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48. ALMEHDI Aslam

# of Collaborated Projects: 1 results

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49. CHUI Chanthoeun

# of Collaborated Projects: 1 results

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50. KAPPART Kai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. MICKE Patrick

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
52. ÖSTMAN Arne

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. Coluzzi Donald J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. NAGASE Takahide

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Ohshima Mitsuhiro 大島 光宏

大島 光宏 オオシマ ミツヒロ

OHSHIMA Mitsuhiro 大島 光宏

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Development of molecular targeted drug for periodontitis based on the causative genes.Principal Investigator

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Establishment of an effective three dimensional culture model for screening of molecular targeted drug for periodontitisPrincipal Investigator

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The roles of platelet-derived factors in periodontal tissuePrincipal Investigator

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Fibronectin participates in the initiation of periodontitisPrincipal Investigator

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Ohshima Mitsuhiro 大島光宏

大島光宏オオシマミツヒロ

OHSHIMA Mitsuhiro 大島光宏

[Book] 最新　動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術2014