KOBAYASHI Tetsuo 小林哲夫

Researcher Number	00215344
Other IDs
Affiliation (Current)	2020: 新潟大学, 医歯学総合病院, 准教授
Affiliation (based on the past Project Information) *help	2007 – 2018: Niigata University, 医歯学総合病院, 准教授 2004 – 2006: 新潟大学, 医歯学総合病院, 助教授 2003 – 2004: NIIGATA UNIVERSITY, Medical and Dental Hospital, Lecturer, 医歯学総合病院, 講師 2002: Dental Hospital Lecturer, 歯学部附属病院, 講師 2001: 新潟大学, 大学院・医歯学総合研究科, 助手 … More
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontal dentistry / Conservative dentistry / Periodontology Except Principal Investigator Periodontal dentistry / Periodontal dentistry / Surgical dentistry / Periodontology / Conservative dentistry
Keywords	Principal Investigator 歯周炎 / Porphyromonas gingivalis / 遺伝子多型 / 好中球 / 関節リウマチ / r40kDa OMP / FcαR / 歯肉溝滲出液 / 遺伝子 / サイトカイン … More Except Principal Investigator 歯周炎 / サイトカイン / in situ hybridization / RT-PCR / Periodontitis / 歯周病 / 遺伝子 / 疾患感受性遺伝子 / SNP解析 / 免疫グロブリン受容体 / リウマチ / 関節リウマチ / TIMP / 歯肉溝滲出液 / r40kDa OMP / Porphyromonas gingivalis / 遺伝子多型 / FcγR / FcγRIIIb / TNFR2 / 膠原病 / リスク遺伝子 / RNA発現 / プロテオーム / 歯学 / 蛋白質 / 口腔多発癌 / IL-6 / エピジェネティクス / ｴﾋﾟｼﾞｪﾈﾃｨｸｽ / インターロイキン6 / ゲノム / 標的療法 / サイトカイン遺伝子 / 糖尿病 / 局所免疫応答 / 宿主菌相互作用 / 生体防御の歪み / Th細胞 / 多形核白血球 / 機能低下 / 好酸球 / 免疫ネットワーク / 遺伝子発現 / T細胞サブセット / 顆粒球機能 / 免疫組織化学 / RNAse Protection assay / Local host immune response / Host-parasite interaction / Biased host-defense network / Th cells / Polymorphonuclear leukocytes / Functional impairment / Eosinophil / 好中球補体レセプター / 接着分子 / コラゲナーゼインヒビター / T細胞レセプター / Gingival Crericular Fluid / complement Receptor / 易感受性 / Susceptibility / Gene / Fc受容体 / 二極特異抗体 / 免疫療法 / Porvhvromonas gingivalis / 好中球 / 二極特異的抗体 / Fc receptor / Bispecific antibody / Immunothearpy / Periodonlal disease / Neutrophils / 診断法 / スクリーニング / 歯周病原細菌 / PCR法 / Periodontal Disease / Diagnosis / Screening / Preiodontal Pathogen / PCR method / cytokine / 免疫グロブリンFc受容体 / インターロイキン1 / カスタムメード療法 / 抗体療法 / 抗サイトカイン療法 / 抗TNFa抗体 / 抗TNFα抗体 / リスク診断 / 特異的抗体療法 / FcαR / IL-6R / periodontitis / gene polymorphisms / Immunoglobulin Fc receptor / Interleukin-1 / custom-made therapy / antibody therapy / cytokine therapy / Anti-TNFα antibody / 口腔扁平苔癬 / ナノインベーダー法 / Oral lichen planus / Susceptible gene / SNP analysis / Immunoglobulin receptor / Cytokine / Nano-Invader assay / 免疫学 / 病理学 / 細胞生物学 / 抑制性レセプター / IgG / Periodontal disease / Immunology / Gene polymorphism / Pathology / Cell biology / JAK分子標的 / 抗菌療法 / 関節リュウマチ Less

Analysis of the role of carbamylated peptide and NET for the association between periodontitis and rheumatoid arthritisPrincipal InvestigatorOngoing
- Principal Investigator
  
  小林哲夫
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
An analysis of therapeutic and functional efficiency of targeting Janus kinase and periodontal bacteria in patients with periodontitis and rheumatoid arthritis
- Principal Investigator
  
  YOSHIE HIROMASA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
A profiling of citrullination in relation to shared mechanisms in periodontitis and rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
Establishment of the cytokine targeted therapy based on the pathogenesis of periodontitis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Analysis of Genome Methylation Profile in Relation to Common Mechanisms of Periodontitis and Rhematoid Arthritis OnsetPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Susceptible gene search using single nucleotide polymorphism analysis in multiple primary oral cancer
- Principal Investigator
  
  FUJITA Hajime
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Niigata University
The role of Fc receptor genes in regulation of signal expression associated with susceptibility to periodontitisPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Assessment of 14 candidate gene polymorphisms as a risk factor for oral lichen planus in Japanese population
- Principal Investigator
  
  FUJITA Hajime
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Niigata University
Immune regulation by the inhibitory IgG receptor related to the susceptibility of periodontitis
- Principal Investigator
  
  SUGITA Noriko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  NIIGATA UNIVERSITY
Development of periodontal custom made therapy based on gene polymorphisms
- Principal Investigator
  
  HIROMASA Yoshie
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
The genome wide scan analysis system for periodontal diseases susceptible genesPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo, 田井秀明
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Determination of common risk genes associated with periodontitis and autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  NIIGATA UNIVERSITY
General study of development of periodontal disease examination
- Principal Investigator
  
  KAWAGUCHI Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontal dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Genetic diagnosis and immunoglobulin A receptor targeting therapy for periodontitisPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  NIIGATA UNIVERSITY
Fc receptor gene analysis and immunotherapy with bispecific antibody for periodontal disease
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  NIIGATA UNIVERSITY
Development of Immunotherapy of Refractory Periodontitis with Anti-Fc Receptor Bispecific AntibodiesPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Inhibitory IgG receptor as an immunoregulator and a relevant factor for periodontitis susceptibilityPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo, 杉田典子
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  NIIGATA UNIVERSITY
Identification of specific genes related to susceptibility to periodontitis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Periodontal dentistry
- Research Institution
  NIIGATA UNIVERSITY
Analysis of neutrophil Fc receptor phenotype in early onset periodontitisPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Niigata University
ポルフィロモナス・ジンジバリスによる歯肉溝滲出液好中球殺菌能の抑制機序の解析Principal Investigator
- Principal Investigator
  
  小林哲夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Niigata University
Host defense mechanism in human periodontitis
- Principal Investigator
  
  HARA Kohji
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Niigata University
Periodontal Disease and the Immune System.
- Principal Investigator
  
  HARA Kohji
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Niigata University

[Book] 関節リウマチ治療中における感染症のマネジメント－関節リウマチ治療・ステップアップのために－2014
- Author(s)
  小林哲夫、伊藤　聡、中園　清、村澤　章、吉江弘正
- Total Pages
  7
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-26463130
[Book] 関節リウマチ治療中における感染症のマネジメント－関節リウマチ治療・ステップアップのために－2014
- Author(s)
  小林哲夫、伊藤　聡、中園　清、村澤　章、吉江弘正
- Total Pages
  7
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24659922
[Book] リウマチ病セミナーXXIV2013
- Author(s)
  小林哲夫
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-22592309
[Book] イラストで語る歯科医学最前線2013
- Author(s)
  小林哲夫、吉江弘正
- Publisher
  クインテッセンス出版
- Data Source
  KAKENHI-PROJECT-22390396
[Book] AT THE FOREFRONT. Illustrated Topics in Dental Research and Clinical Practice2012
- Author(s)
  Tetsuo Kobayashi、Hiromasa Yoshie
- Publisher
  Quintessence Publishing Co, Inc
- Data Source
  KAKENHI-PROJECT-22390396
[Book] Preventive Periodontology臨床を支えるサイエンスを知る、唾液検査を活用する、生活習慣病を予防する2007
- Author(s)
  小林哲夫、吉江弘正
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-19592383
[Book] Preventive Periodontology臨床を支えるサイエンスを知る、唾液検査を活用する、生活習慣病を予防する2007
- Author(s)
  小林哲夫、吉江弘正
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-19390535
[Book] 歯周病と全身の健康を考える2004
- Author(s)
  小林哲夫
- Total Pages
  8
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Effects of tofacitinib on the clinical features of periodontitis in patients with rheumatoid arthritis: two case reports.2019
- Author(s)
  Kobayashi T, Ito S, Murasawa A, Ishikawa H, Yoshie H
- Journal Title
  
  BMC Rheumatology
  
  Volume: 3 Pages: 13-13
- DOI
  10.1186/s41927-019-0062-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11983
[Journal Article] Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study2018
- Author(s)
  Kaneko Chihiro、Kobayashi Tetsuo、Ito Satoshi、Sugita Noriko、Murasawa Akira、Nakazono Kiyoshi、Yoshie Hiromasa
- Journal Title
  
  PLoS ONE
  
  Volume: 13
- DOI
  10.1371/journal.pone.0192365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11983, KAKENHI-PROJECT-15K11384, KAKENHI-PROJECT-15K15764
[Journal Article] The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study2018
- Author(s)
  Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
- Journal Title
  
  Journal of Periodontology
  
  Volume: 89(3) Pages: 315-324
- DOI
  10.1002/jper.17-0412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K11983, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15764
[Journal Article] Serum amyloid A promotes E-selectin expression via toll-like receptor 2 in human aortic endothelial cells.2017
- Author(s)
  Nishida E, Aino M, Kobayashi SI, Okada K, Ohno T, Kikuchi T, Hayashi JI, Yamamoto G, Hasegawa Y, Mitani A.
- Journal Title
  
  Mediators Inflamm
  
  Volume: 7150509 Pages: 7150509-7150509
- DOI
  10.1155/2016/7150509
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-25862065, KAKENHI-PROJECT-16K11466, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-26463149, KAKENHI-PROJECT-16K20684
[Journal Article] Increased expression of interleukin-6 (IL-6) gene transcript in relation to IL-6 promoter hypomethylation in gingival tissue from patients with chronic periodontitis2016
- Author(s)
  Kobayashi T, Ishida K, Yoshie H.
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 69 Pages: 89-94
- DOI
  10.1016/j.archoralbio.2016.05.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463130, KAKENHI-PROJECT-15K15764
[Journal Article] Interleukin-6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors2016
- Author(s)
  Kobayashi T, Ito S, Kobayashi D, Kojima A, Shimada A, Narita I, Murasawa A, Nakazono K, Yoshie H
- Journal Title
  
  Clinical and Experimental Dental Research
  
  Volume: 1 Pages: 63-73
- DOI
  10.1002/cre2.11
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463130, KAKENHI-PROJECT-15K15764, KAKENHI-PROJECT-25253104
[Journal Article] Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis2016
- Author(s)
  Shimada A, Kobayashi T, Ito S, Okada M, Murasawa A, Nakazono K, Yoshie H
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 51 Pages: 103-111
- DOI
  10.1111/jre.12288
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463130, KAKENHI-PROJECT-15K15764, KAKENHI-PROJECT-25253104
[Journal Article] Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis2016
- Author(s)
  Kobayashi T, Ito S, Kobayashi D, Shimada A, Narita I, Murasawa A, Nakazono K, Yoshie H.
- Journal Title
  
  PLoS ONE
  
  Volume: 11
- DOI
  10.1371/journal.pone.0154182
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463130, KAKENHI-PROJECT-15K15764
[Journal Article] Tumor necrosis factor-alpha gene promoter methylation in Japanese adults with chronic periodontitis and rheumatoid arthritis2016
- Author(s)
  Kojima A, Kobayashi T, Ito S, Murasawa A, Nakazono K, Yoshie H.
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 51 Pages: 350-358
- DOI
  10.1111/jre.12314
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463130, KAKENHI-PROJECT-15K15764
[Journal Article] Host Responses in the Link between Periodontitis and Rheumatoid Arthritis.2015
- Author(s)
  Kobayashi T, Yoshie H
- Journal Title
  
  Curr Oral Health Rep.
  
  Volume: 2 Pages: 1-8
- DOI
  10.1007/s40496-014-0039-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659922, KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463130
[Journal Article] Comparative analysis of serum proteins in relation to rheumatoid arthritis and2014
- Author(s)
  Tomoko Yokoyama, Tetsuo Kobayashi, et al.
- Journal Title
  
  Journal of Periodontology
  
  Volume: 85 Pages: 103-112
- DOI
  10.1902/jop.2013.120741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309, KAKENHI-PROJECT-24659922
[Journal Article] Inflammatory Bone Loss in Experimental Periodontitis Induced by Aggregatibacter actinomycetemcomitans in Interleukin-1 Receptor Antagonist Knockout Mice.2014
- Author(s)
  Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J, Nishihara T, Maeda H, Noguchi T
- Journal Title
  
  Infection and Immunity
  
  Volume: 82 Pages: 1904-1913
- DOI
  10.1128/iai.01618-13
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463149
[Journal Article] Periodontal and Serum Protein Profiles in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitor Adalimumab2014
- Author(s)
  Kobayashi T, Yokoyama T, Ito S, Kobayashi D, Yamagata A, Okada M, Oofusa K, Narita I, Murasawa A, Nakazono K, Yoshie H
- Journal Title
  
  J Periodontol.
  
  Volume: 85 Pages: 1480-1488
- DOI
  10.1902/jop.2014.140194
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659922, KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463130
[Journal Article] Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis.2014
- Author(s)
  Tetsuo Kobayashi, et al.
- Journal Title
  
  Open Journal of Stomatology
  
  Volume: 4 Pages: 49-55
- DOI
  10.4236/ojst.2014.42009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22592309, KAKENHI-PROJECT-24659922, KAKENHI-PROJECT-25253104
[Journal Article] Comparative Analysis of Serum Proteins in Relation to Rheumatoid Arthritis and Chronic Periodontitis2014
- Author(s)
  Yokoyama T, Kobayashi T, Ito S, Yamagata A, Ishida K, Okada M, Oofusa K, Murasawa A, Yoshie H
- Journal Title
  
  J Periodontol
  
  Volume: 85(1) Pages: 103-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis2014
- Author(s)
  Kobayashi T, Okada M, Ito S, Kobayashi D, Shinhara A, Muramatsu T, Kobayashi T, Narita I, Nakazono K, Murasawa A, Yoshie H
- Journal Title
  
  Open Journal of Stomatology
  
  Volume: 4(2) Pages: 49-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Assessment of Interleukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Chronic Periodontitis.2014
- Author(s)
  Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H
- Journal Title
  
  J Periodontol
  
  Volume: (in press) Pages: 57-67
- DOI
  10.1902/jop.2013.120696
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22390396, KAKENHI-PROJECT-22592309, KAKENHI-PROJECT-24659922, KAKENHI-PROJECT-25253104
[Journal Article] Assessment of Interleukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Chronic Periodontitis2014
- Author(s)
  Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H
- Journal Title
  
  J Periodontol
  
  Volume: 85(1) Pages: 57-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Periodontitis-activated monocytes/macrophages cause aortic inflammation.2014
- Author(s)
  Miyajima S, Naruse K, Kobayashi Y, Nakamura N, Nishikawa T, Adachi K, Suzuki Y, Kikuchi T, Mitani A, Mizutani M, Ohno N, Noguchi T, Matsubara T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 4 Pages: 5171-5171
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Periodontal Treatment Decreases Levels of Antibodies to Porphyromonas gingivalis and Citrulline in Patients with Rheumatoid Arthritis and Periodontitis2013
- Author(s)
  Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A, Yoshie H
- Journal Title
  
  J Periodontol
  
  Volume: 84(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Lipopolysaccharide of Aggregati- bacter actinomycetemcomitans upregulates inflammatory cytokines, PGE2 synthesis, and osteoclast formation in IL-1Ra deficient mice.2013
- Author(s)
  Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T.
- Journal Title
  
  J Periodont Res
  
  Volume: 48 Pages: 748-756
- DOI
  10.1111/jre.12065
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-25253104
[Journal Article] Periodontal Treatment Decreases Levels of Antibodies to Porphyromonas gingivalis and Citrulline in Patients with Rheumatoid Arthritis and Periodontitis2013
- Author(s)
  Moe Okada, Tetsuo Kobayashi, et al.
- Journal Title
  
  Journal of Periodontology
  
  Volume: 84
- DOI
  10.1902/jop.2013.130079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Association of the FcγRIIB-nt645+25A/G polymorphism with the expression level of the FcγRIIb receptor, the antibody response to Porphyromonas gingivalis and the severity of periodontitis2012
- Author(s)
  Sugita N, Iwanaga R, Kobayashi T, Yoshie H
- Journal Title
  
  J Periodont Res
  
  Volume: 47(1) Pages: 105-113
- DOI
  10.1111/j.1600-0765.2011.01411.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396
[Journal Article] Interleukin-6 gene promoter methylation in rheumatoid arthritis and2012
- Author(s)
  Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, Abe A, Murasawa A, Yoshie H
- Journal Title
  
  Journal of Periodontology
  
  Volume: 83(7) Pages: 917-925
- DOI
  10.1902/jop.2011.110356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396, KAKENHI-PROJECT-22592309, KAKENHI-PROJECT-24659922
[Journal Article] 歯周炎と関節リウマチ-関連性と臨床対応-2012
- Author(s)
  小林哲夫、吉江弘正
- Journal Title
  
  日本歯周病学会会誌
  
  Volume: 54巻1号 Pages: 11-17
- NAID
  10030555150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396
[Journal Article] Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis2012
- Author(s)
  Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, Abe A, Murasawa A, Yoshie H
- Journal Title
  
  J Periodontol
  
  Volume: 83(7) Pages: 917-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults2011
- Author(s)
  Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H
- Journal Title
  
  Journal of Periodontology
  
  Volume: 82(10) Pages: 1433-1441
- DOI
  10.1902/jop.2011.110020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396, KAKENHI-PROJECT-22592309
[Journal Article] Characterization of human-type monoclonal antibod es against reduced form of hemin binding protein 35 from Porphyromonas gingival s.2011
- Author(s)
  Shibata Y, Okano S, Shiroza T, Tahara T, Nakazawa K, Kataoka S, Ishida I, Kobayashi T, Yoshie H, Abiko Y
- Journal Title
  
  J Periodont Res
  
  Volume: Vol46 Pages: 673-681
- DOI
  10.1111/j.1600-0765.2011.01389.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390497, KAKENHI-PROJECT-22390396, KAKENHI-PROJECT-22592078
[Journal Article] Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults2011
- Author(s)
  Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H
- Journal Title
  
  J Periodontol
  
  Volume: 82(10) Pages: 1433-1441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology
  
  Volume: VOL.81 Pages: 650-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology
  
  Volume: VOL.81 Pages: 650-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010
- Author(s)
  Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
- Journal Title
  
  J. Periodontol
  
  Volume: 81(5) Pages: 650-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592309
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010
- Author(s)
  Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
- Journal Title
  
  J. Periodontol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults.2010
- Author(s)
  Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
- Journal Title
  
  J. Periodontol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Proteomic profiling of human neutrophils in relation to immunoglobulin G Fc receptor IIIB polymorphism2010
- Author(s)
  Yokoyama T, Kobayashi T, Yamamoto K, Yamagata A, Oofusa K, Yoshie H
- Journal Title
  
  J Periodont Res
  
  Volume: 45(6) Pages: 780-787
- DOI
  10.1111/j.1600-0765.2010.01300.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Assessment of 14 functional gene polymorphisms in Japanese patients with oral lichen planus : a pilot case-control study2009
- Author(s)
  Fujita H, Kobayashi T, Tai H, Nagata M, Hoshina H, Hishizawa R, Takagi R, Yoshie H
- Journal Title
  
  International Journal of Oral and Maxillofacial Surgery 38(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592286
[Journal Article] Assessment of chromosome 19 for genetic association in severe chronic periodontitis2009
- Author(s)
  Tabeta K, Shimada Y, Tai H, Ishihara Y, Noguchi T, Soga Y, Takashiba S, Suzuki G, Kobayashi T, Oka A, Kobayasi T, Yamazaki K, Inoko H, Yoshie H
- Journal Title
  
  J. Periodontol 80(4)
  
  Pages: 663-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009
- Author(s)
  Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, Sumida T, Yoshie H
- Journal Title
  
  J. Periodontol 80(5)
  
  Pages: 792-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Mannose binding lectin gene polymorphism and the severity of chronic periodontitis2009
- Author(s)
  Tsutsumi A, Kobayashi T, Ito S, Goto D, Matsumoto I, Yoshie H, Sumida T
- Journal Title
  
  Jpn. J. Clin. Immunol 32(1)
  
  Pages: 48-52
- NAID
  10024961926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009
- Author(s)
  小林哲夫
- Journal Title
  
  Journal of Periodontology 80(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 80(5)
  
  Pages: 792-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Genetic risk factors for periodontitis in a Japanese population2009
- Author(s)
  Kobayashi T, Nagata T, Murakami S, Takashiba S, Kurihara H, Izumi Y, Numabe Y, Watanabe H, Kataoka M, Nagai A, Hayashi J, Ohyama H, Okamatsu Y, Inagaki Y, Tai H, Yoshie H
- Journal Title
  
  J Dent Res 88(12)
  
  Pages: 1137-1141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009
- Author(s)
  Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, Sumida T, Yoshie H
- Journal Title
  
  Periodontol 80(5)
  
  Pages: 792-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Genetic risk factors for periodontitis in a Japanese population2009
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Dental Research 88(12)
  
  Pages: 1137-1141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Genetic risk factors for periodontitis in a Japanese population2009
- Author(s)
  Kobayashi T, Nagata T, Murakami S, Takashiba S, Kurihara H, Izumi Y, Numabe Y, Watanabe H, Kataoka M, Nagai A, Hayashi J, Ohyama H, Okamatsu Y, Inagaki Y, Tai H, Yoshie H
- Journal Title
  
  J Dent Res 88(12)
  
  Pages: 1137-1141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 80(5)
  
  Pages: 792-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Mannose binding lectin gene polymorphism and the severity of chronic periodontitis2009
- Author(s)
  Tsutsumi A, Kobayashi T, Ito S, Goto D, Matsumoto I, Yoshie H, Sumida T
- Journal Title
  
  Jpn. J. Clin. Immunol 32(1)
  
  Pages: 48-52
- NAID
  10024961926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Genetic risk factors for periodontitis in a Japanese population2009
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Dental Research 88(12)
  
  Pages: 1137-1141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Association of interleukin-1 receptor anatagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method2008
- Author(s)
  Komatsu Y, Galicia JC, Kobayashi T, Yamazaki K, Yoshie H
- Journal Title
  
  Int. J. Immunogenet 35(2)
  
  Pages: 165-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] Lower antibody response to Porphyromonas gingivalis associated with immunoglobulin G Fcgamma receptor IIB polymorphism2008
- Author(s)
  Honma Y, Sugita N, Kobayashi T, Abiko Y, Yoshie H
- Journal Title
  
  Periodotnt Res 43(6)
  
  Pages: 706-711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Association of interleukin-1 receptor anatagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method2008
- Author(s)
  Komatsu Y, Galicia JC, Kobayashi T, Yamazaki K, Yoshie H
- Journal Title
  
  Int. J. Immunogenet 35(2)
  
  Pages: 165-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue2008
- Author(s)
  Kubota T, Itagaki M, Oshino C, Nagata M, Morozumi T, Kobayashi T, Takagi R, Yoshie H
- Journal Title
  
  J. Periodontol 79(1)
  
  Pages: 166-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Lower antibody response to Porphyromonas gingivalis associated with immunoglobulin G Fcgamma receptor IIB polymorphism2008
- Author(s)
  Honma Y, Sugita N, Kobayashi T, Abiko Y, Yoshie H
- Journal Title
  
  J Periodotnt Res 43(6)
  
  Pages: 706-711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] The combined genotypes of stimulatory and inhibitory Fcγ receptor associated with systemic lupus erythematosus and periodontitis in Japanese adults.2007
- Author(s)
  Kobayashi T, Ito S, Yasuda K, Kuroda T, Yamamoto K, Sugita N, Tai H, Narita I, Gejyo F, Yoshie.H.
- Journal Title
  
  Journal of Periodontology 78-3
  
  Pages: 467-474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592065
[Journal Article] The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis2007
- Author(s)
  Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, Sumida T, Gejyo F, Yoshie H
- Journal Title
  
  J. Periodontol 78(12)
  
  Pages: 2311-2318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] The FcgammaRIIa polymorphism influences production of interleukin-1 by mononuclear cells2007
- Author(s)
  Yamamoto K, Kobayashi T, Sugita N, TaiH, Yoshie H
- Journal Title
  
  Int. J. Immunogene 34(5)
  
  Pages: 369-372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] The combined genotypes of stimulatory and inhibitory Fcγ receptor associated with systemic lupus erythematosus and periodontitis in Japanese adults.2007
- Author(s)
  Kobayashi T, Ito S, Yasuda K, Kuroda T, Yamamoto K, Sugita N, Tai H, Narita I, Gejyo F, Yoshie H.
- Journal Title
  
  Journal of Periodontology 78(3)
  
  Pages: 467-474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17592159
[Journal Article] The combined genotypes of stimulatoly and inhibitoly Fcγ receptor associated with systemic lupus erythematosus and periodontitis in Japanese adults.2007
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 78・3
  
  Pages: 467-474
- Data Source
  KAKENHI-PROJECT-16592065
[Journal Article] The combined genotypes of stimulatory and inhibitory Fcγ receptor associated with systemic lupus erythematosus and periodontitis in Japanese adults.2007
- Author(s)
  Kobayashi T
- Journal Title
  
  Journal of Periodontology 78・3
  
  Pages: 467-474
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17592159
[Journal Article] The interleukin-1 and Fcγ receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis2007
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 78
  
  Pages: 2311-2318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] The role of genetic polymorphisms in periodontitis.2007
- Author(s)
  Yoshie H, Kobayashi T, Tai H, Galicia JC.
- Journal Title
  
  Periodontology 2000 43-2
  
  Pages: 102-132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592065
[Journal Article] The combined genotypes of stimulatory and inhibitory Fcγ receptor associated with systemic lupus erythematosus and periodontitis in Japanese adults2007
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 78・3
  
  Pages: 467-474
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592065
[Journal Article] The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis2007
- Author(s)
  Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, Sumida T, Gejyo F, Yoshie H
- Journal Title
  
  J. Periodontol 78(12
  
  Pages: 2311-2318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592383
[Journal Article] The FcgammaRIIa polymorphism influences production of interleukin-1 by mononuclear cells. Int2007
- Author(s)
  Yamamoto K, Kobayashi T, Sugita N, TaiH, Yoshie H
- Journal Title
  
  J. Immunogenet 34(5)
  
  Pages: 369-372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis.2006
- Author(s)
  Kobayashi T, Kaneko S, Tahara T, Hayakawa M, Abiko Y, Yoshie H.
- Journal Title
  
  Journal of Periodontology 77-3(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis2006
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 77・3(In press)
- Data Source
  KAKENHI-PROJECT-16390612
[Journal Article] The role of genetic polymorphisms in periodontitis.2006
- Author(s)
  Yoshie H, Kobayashi T, Tai H, Galicia JC.
- Journal Title
  
  Periodontology 2000 (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis2006
- Author(s)
  T.Kobayashi
- Journal Title
  
  Journal of Periodontology 77/3
  
  Pages: 364-369
- Data Source
  KAKENHI-PROJECT-16390612
[Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis2006
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 77・3(In press)
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Expression of FcγRIIB in human blood and gingiva with periodontitis.2006
- Author(s)
  Sugita N, Kobayashi K, Hanaoka J, Kobayahashi T, Yoshie H.
- Journal Title
  
  Journal of Clinical Periodontology 33(7)
  
  Pages: 61-61
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17592159
[Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A an outer membrane protein in chronic periodontitis2006
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 77・3(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Genetic polymorphisms and periodontitis.2005
- Author(s)
  Yoshie H, Galicia JC, Kobayashi T, Tai H
- Journal Title
  
  International Congress Series 1284
  
  Pages: 131-139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592065
[Journal Article] The trans-chromosomic mouse-derived human monoclonal antibody promotes phagocytosis of Porphyromonas gingivalis by neutrophils2005
- Author(s)
  Takauchi A, Kobayashi T, Tahara T, Nakazawa K, Hayakawa M, Shibata Y, Ishida I, Abiko Y, Yoshie H.
- Journal Title
  
  Journal of Periodontology 76-5
  
  Pages: 18-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] FcγRIIIb genotypes and smoking in periodontal disease progression among community-dwelling older adults in Japan.2005
- Author(s)
  Yoshihara A, Sugita N, Yamamoto K, Kobayashi T, Hirotomi T, Ogawa H, Miyazaki H, Yoshie H.
- Journal Title
  
  Journal of Periodontology 76-2
  
  Pages: 250-255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Targeting of Porphyromonas gingivalis with a bispecific antibody directed to FcαRI (CD89) improves in vitro clearance by gingival crevicular neutrophils2004
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Vaccine 23(5)
  
  Pages: 585-594
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Targeting of Porphyromonas gingivalis with a bispecific antibody directed to FcαRI (CD89) improves in vitro clearance by gingival crevicular neutrophils.2004
- Author(s)
  Kobayashi T, Takauchi A, van Spriel AB, Vile HA, Hayakawa M, Shibata Y, abiko Y, van de Winkel JGJ, Yoshie H.
- Journal Title
  
  Vaccine 23-5
  
  Pages: 585-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Targeting of Porphyromonas gingivalis with a bispecific antibody directed to FcαRI(CD89)improves in vitro clearance by gingival erevicular neutrophils2004
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Vaccine 23・5
  
  Pages: 585-594
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Association of Fcγ receptor IIa genotype with chronic periodontitis in Caucasians.2004
- Author(s)
  Yamamoto K, Kobayashi T, Grossi S, Ho AW, Genco RJ, Yoshie H, De Nardin E.
- Journal Title
  
  Journal of Periodontology 75-4
  
  Pages: 515-520
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] A novel polymorphism of FcαRI (CD89) associated with aggressive periodontitis.2004
- Author(s)
  Kaneko S, Kobayashi T, Yamamoto K, Jansen MD, van de Winkel JGJ, Yoshie H.
- Journal Title
  
  Tissue Antigens 63-6
  
  Pages: 572-577
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Targeting of Porphyromonas gingivalis with a bispecific antibody directed to FcαRI(CD89) improves in vitro clearance by gingival crevicular neutrophils.2004
- Author(s)
  T.Kobayashi
- Journal Title
  
  Vaccine 23(5)
  
  Pages: 585-594
- Data Source
  KAKENHI-PROJECT-16390612
[Journal Article] Interleukin-4 gene polymorphisms in Japanese and Caucasian patients with aggressive periodontitis.2004
- Author(s)
  Gonzales JR, Kobayashi T, Michel J, Mann M, Yoshie H, Meyle J.
- Journal Title
  
  Journal of Clinical Periodontology 31-5
  
  Pages: 384-389
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitis.2004
- Author(s)
  Shimada Y, Tai H, Endo M, Kobayashi T, Akazawa K, Yamazaki K.
- Journal Title
  
  Journal of Clinical Periodontology 31-6
  
  Pages: 463-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Risk of Periodontitis in Systemic Lupus Erythematosus is Associated with Fcγ Receptor Polymorphisms2003
- Author(s)
  Tetsuo Kobayashi
- Journal Title
  
  Journal of Periodontology 74・3
  
  Pages: 378-384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Risk of Periodontitis in Systemic Lupus Erythematosus is Associated with Fcγ Receptor Polymorphisms.2003
- Author(s)
  Kobayashi T, Ito S, Yamamoto K, Hasegawa H, Sugita N, Kuroda T, Kaneko S, Narita I, Yasuda K, Nakano M, Gejyo F, Yoshie H.
- Journal Title
  
  Journal of Periodontology 74-3
  
  Pages: 378-384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] FcγRIIB gene polymorphisms in Japanese periodontitis patients.2003
- Author(s)
  Yasuda K, Sugita N, Kobayashi T, Yamamoto K, Yoshie H.
- Journal Title
  
  Genes and Immunity 4-8
  
  Pages: 541-546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Evidence for non-random distribution of Fcγ receptor genotype combinations.2003
- Author(s)
  van der Pol W-L, Jansen MD, Sluiter WJ, van de Sluis B, Leppers-van de Straat FGJ, Kobayashi T, Westendrop RGJ, Huizinga TWJ, van de Winkel JGJ.
- Journal Title
  
  Immunogenetics 55-4
  
  Pages: 240-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390644
[Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults
- Author(s)
  Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
- Journal Title
  
  J. Periodontol
  
  Volume: 81(5) Pages: 650-657
- DOI
  10.1902/jop.2010.090688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] 歯周病治療による関節リウマチ活動度と血清カルバミル化蛋白レベルの低下2018
- Author(s)
  小林哲夫
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11983
[Presentation] Porphyromonas gingivalis peptidylarginine deiminase as a risk factor for the response to cytokine targeted therapy in patients with rheumatoid arthritis2018
- Author(s)
  Kobayashi T
- Organizer
  EuroPerio 9
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11983
[Presentation] 歯周炎が関節リウマチ発症に及ぼす影響2018
- Author(s)
  小林哲夫
- Organizer
  日本臨床歯周病学会第36回年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11983
[Presentation] 関節リウマチ患者におけるbiologic DMARDs（bDMARDs）治療反応性予測因子の解析2017
- Author(s)
  小林哲夫、伊藤　聡、小林大介、成田一衛、村澤　章、中園　清、吉江弘正
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] 歯周病と関節リウマチ－現状と展望、歯科の役割－2017
- Author(s)
  小林　哲夫
- Organizer
  日本歯周病学会60周年記念京都大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11983
[Presentation] 歯周炎と全身疾患（糖尿病・関節リウマチ）に共通するリスク遺伝子の解析2017
- Author(s)
  小林哲夫、木戸淳一、石原裕一、大森一弘、三谷章雄、高柴正悟、永田俊彦、吉江弘正
- Organizer
  第60回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] 歯周炎と全身疾患（糖尿病・関節リウマチ）に共通するリスク遺伝子の解析2017
- Author(s)
  小林　哲夫
- Organizer
  第60回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11983
[Presentation] 関節リウマチ患者におけるbiologic DMARDs（bDMARDs）治療反応性予測因子の解析2017
- Author(s)
  小林　哲夫
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11983
[Presentation] 慢性歯周炎罹患歯肉組織におけるIL-6プロモーター低メチル化と遺伝子転写発現亢進2016
- Author(s)
  小林哲夫、石田光平、吉江弘正
- Organizer
  第59回秋季日本歯周病学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] 歯周炎併発と関節リウマチ活動度との関連性の解析2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  日本歯科保存学会2016年度春季学術大会（第144回）
- Place of Presentation
  栃木県総合文化センター（栃木県宇都宮市）
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] Porphyromonas gingivalis PAD血清抗体価のサイトカイン標的療法反応性への影響2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 関節リウマチ患者におけるPorphyromonas gingivalis PAD血清抗体価とbiologic DMARDs反応性との関連性2016
- Author(s)
  小林哲夫、伊藤　聡、小林大介、成田一衛、村澤　章、中園　清、吉江弘正
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市)
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] Porphyromonas gingivalis PAD IgG抗体価と関節リウマチ治療応答性との関連2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  日本歯科保存学会2016年度秋季学術大会（第145回）
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] 慢性歯周炎罹患歯肉組織におけるIL-6プロモーター低メチル化と遺伝子転写発現亢進2016
- Author(s)
  小林哲夫、石田光平、吉江弘正
- Organizer
  第59回秋季日本歯周病学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] 関節リウマチ患者におけるPorphyromonas gingivalis PAD血清抗体価とbiologic DMARDs反応性との関連性2016
- Author(s)
  小林哲夫、伊藤　聡、小林大介、成田一衛、村澤　章、中園　清、吉江弘正
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] Porphyromonas gingivalis PAD IgG抗体価と関節リウマチ治療応答性との関連2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  日本歯科保存学会2016年度秋季学術大会（第145回）
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] Porphyromonas gingivalis PAD IgG抗体価と関節リウマチ治療応答性との関連2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  日本歯科保存学会2016年度秋季学術大会（第145回）
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] 歯周炎併発と関節リウマチ活動度との関連性の解析2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  日本歯科保存学会2016年度春季学術大会（第144回）
- Place of Presentation
  栃木県総合文化センター（栃木県宇都宮市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] 歯周炎併発と関節リウマチ活動度との関連性の解析2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  日本歯科保存学会2016年度春季学術大会（第144回）
- Place of Presentation
  栃木県総合文化センター（栃木県宇都宮市）
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] Porphyromonas gingivalis PAD血清抗体価のサイトカイン標的療法反応性への影響2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] 慢性歯周炎罹患歯肉組織におけるIL-6プロモーター低メチル化と遺伝子転写発現亢進2016
- Author(s)
  小林哲夫、石田光平、吉江弘正
- Organizer
  第59回秋季日本歯周病学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 関節リウマチ患者におけるPorphyromonas gingivalis PAD血清抗体価とbiologic DMARDs反応性との関連性2016
- Author(s)
  小林哲夫、伊藤　聡、小林大介、成田一衛、村澤　章、中園　清、吉江弘正
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] Porphyromonas gingivalis PAD血清抗体価のサイトカイン標的療法反応性への影響2016
- Author(s)
  小林哲夫、島田惇史、吉江弘正
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市)
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] IL-6/sIL-6R enhances cathepsin-B secretion via caveolin-1-mediated ERK1/2 in gingival fibroblasts.2015
- Author(s)
  Goto A, Omori K, Yamaguchi-Tomikawa, Kobayashi H, Yamamoto T, Maeda H, Takashiba S
- Organizer
  the 93rd International Association for Dental Research
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-14
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] アダリムマブ投与前後での歯周・血清蛋白プロファイル2015
- Author(s)
  小林哲夫
- Organizer
  第５９回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] アダリムマブ投与前後での歯周・血清蛋白プロファイル2015
- Author(s)
  小林哲夫
- Organizer
  第５９回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] IL-6受容体阻害薬トシリズマブ投与前後での歯周・血清サイトカインプロファイル2015
- Author(s)
  小林哲夫
- Organizer
  第５８回春季日本歯周病学会学術大会
- Place of Presentation
  幕張メッセ（千葉県幕張市）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] IL-6レセプター阻害による関節リウマチ患者の歯周炎症の改善2015
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2015年度秋季学術大会（第143回）
- Place of Presentation
  文京シビックホール（東京都文京区)
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] IL-6受容体阻害薬トシリズマブ投与前後での歯周・血清サイトカインプロファイル2015
- Author(s)
  小林哲夫
- Organizer
  第58回春季日本歯周病学会学術大会
- Place of Presentation
  幕張メッセ（千葉県幕張市）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] IL-6レセプター阻害による関節リウマチ患者の歯周炎症の改善2015
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2015年度秋季学術大会（第143回）
- Place of Presentation
  文京シビックホール（東京都文京区)
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] アダリムマブ投与前後での歯周・血清蛋白プロファイル2015
- Author(s)
  小林哲夫
- Organizer
  第５９回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] IL-6レセプター阻害による関節リウマチ患者の歯周炎症の改善2015
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2015年度秋季学術大会（第143回）
- Place of Presentation
  文京シビックホール（東京都文京区)
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] IL-6受容体阻害薬トシリズマブ投与前後での歯周・血清サイトカインプロファイル2015
- Author(s)
  小林哲夫
- Organizer
  第５８回春季日本歯周病学会学術大会
- Place of Presentation
  幕張メッセ（千葉県幕張市）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15K15764
[Presentation] 腫瘍壊死因子抑制薬治療前後における歯周・血清蛋白プロファイル2014
- Author(s)
  小林哲夫、横山智子、岡田　萌、吉江弘正
- Organizer
  日本歯科保存学会2014年度秋季学術大会（第141回）
- Place of Presentation
  山形テルサ（山形県山形市）
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 腫瘍壊死因子抑制薬治療前後における歯周・血清蛋白プロファイル2014
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2014年度秋季学術大会（第141回）
- Place of Presentation
  山形テルサ（山形市）
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] ＴＮＦ抑制療法中の関節リウマチ患者における血漿アミノ酸と歯周状態2014
- Author(s)
  小林哲夫、岡田　萌、吉江弘正
- Organizer
  第５７回春季日本歯周病学会学術大会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 糖尿病ラット歯周炎に対するpoly (ADP-ribose) polymerase阻害薬の効果.2014
- Author(s)
  足立圭, 成瀬桂子, 小林泰子, 中村信久, 西川徹, 宮島真一, 鈴木佑基, 水谷誠, 菊池毅, 大野紀和, 野口俊英, 松原達昭
- Organizer
  第５７回春季日本歯周病学会学術大会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] TNF抑制療法中の関節リウマチ患者における血漿アミノ酸と歯周状態2014
- Author(s)
  小林哲夫
- Organizer
  第57回春季日本歯周病学会学術大会
- Place of Presentation
  長良川国際会議場（岐阜市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] TNF抑制療法中の関節リウマチ患者における血漿アミノ酸と歯周状態2014
- Author(s)
  小林哲夫
- Organizer
  第57回春季日本歯周病学会学術大会
- Place of Presentation
  長良川国際会議場（岐阜市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] 関節リウマチ患者における生物学的製剤治療反応へのPorphyromonas gingivalis感染の影響2014
- Author(s)
  岡田　萌、小林哲夫、吉江弘正
- Organizer
  第５７回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] I-6s/IL-6Rは歯肉線維芽細胞から活性を有するリソソーム酵素カテプシンB, Lの分泌を亢進す2014
- Author(s)
  後藤絢香，大森一弘，冨川知子，小林寛也，成石浩司，前田博史，高柴正悟
- Organizer
  第57回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] TNF阻害療法中の関節リウマチ患者のアミノ酸・歯周プロファイル2014
- Author(s)
  小林哲夫
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都）
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] 慢性歯周炎患者および関節リウマチ患者におけるTNF-alpha61537;遺伝子プロモーター領域のメチル化解析2014
- Author(s)
  小島杏里、小林哲夫、石田光平、岡田　萌、吉江弘正
- Organizer
  第５７回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 腫瘍壊死因子抑制薬治療前後における歯周・血清蛋白プロファイル2014
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2014年度秋季学術大会（第141回）
- Place of Presentation
  山形テルサ（山形市）
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] TNF阻害療法中の関節リウマチ患者のアミノ酸・歯周プロファイル2014
- Author(s)
  小林哲夫、伊藤　聡、岡田　萌、小林大介、成田一衛、中園　清、村澤　章、吉江弘正
- Organizer
  第５８回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 歯周治療による関節リウマチ活動度と血清シトルリン濃度の低下2014
- Author(s)
  岡田　萌、小林哲夫、伊藤　聡、阿部麻美、村澤　章、吉江弘正
- Organizer
  第５８回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] TNF阻害療法中の関節リウマチ患者のアミノ酸・歯周プロファイル2014
- Author(s)
  小林哲夫
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都）
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] Porphyromonas gingivalisによるタンパクシトルリン化と関節リウマチとの関連2014
- Author(s)
  小林哲夫
- Organizer
  第５６回歯科基礎医学会学術大会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-26463130
[Presentation] Effect of Interkeukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Periodontitis2013
- Author(s)
  Kobayashi T
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  Nara
- Year and Date
  2013-09-03
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] 関節リウマチ患者におけるトシリズマブ治療の歯周状態への影響2013
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2013年度春季学術大会(第138回)
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2013-06-28
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] トシリズマブ（TCZ）療法中の関節リウマチ患者の歯周状態2013
- Author(s)
  小林哲夫、伊藤　聡、小林大介、成田一衛、村澤　章、吉江弘正：
- Organizer
  第５７回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都国際会館（京都市）
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 関節リウマチ患者におけるトシリズマブ治療の歯周状態への影響.2013
- Author(s)
  小林哲夫、岡田　萌、石田光平、小島杏里、吉江弘正
- Organizer
  日本歯科保存学会2013年度春季学術大会（第138回）
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2013-06-28
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] トシリズマブ(TCZ)療法中の関節リウマチ患者の歯周状態2013
- Author(s)
  小林哲夫
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] 慢性歯周炎患者におけるTNF-a遺伝子プロモーター領域のメチル化解析2013
- Author(s)
  小島杏里、小林哲夫、石田光平、岡田　萌、吉江弘正
- Organizer
  第５６回秋季日本歯周病学会学術大会
- Place of Presentation
  前橋市市民文化会館（前橋市）
- Year and Date
  2013-09-22
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] IL-6受容体抑制治療中の関節リウマチ患者の歯周状態2013
- Author(s)
  小林哲夫、岡田　萌、石田光平、小島杏里、吉江弘正
- Organizer
  第５６回春季日本歯周病学会学術大会
- Place of Presentation
  タワーホール船堀（東京都）
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 関節リウマチ患者における歯周状態のTNF標的療法反応性に及ぼす影響2013
- Author(s)
  横山智子、小林哲夫、岡田　萌、吉江弘正
- Organizer
  第５６回秋季日本歯周病学会学術大会
- Place of Presentation
  前橋市市民文化会館（前橋市）
- Year and Date
  2013-09-22
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 歯周炎罹患組織におけるIL-6遺伝子プロモーター領域のメチル化解析2013
- Author(s)
  石田光平、小林哲夫、横山智子、岡田　萌、小島杏里、小松康高、吉江弘正
- Organizer
  日本歯科保存学会2013年度秋季学術大会（第139回）
- Place of Presentation
  秋田県総合生活文化会館（秋田市）
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] IL-6受容体抑制治療中の関節リウマチ患者の歯周状態2013
- Author(s)
  小林哲夫
- Organizer
  第56回春季日本歯周病学会学術大会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] Effect of Interkeukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Periodontitis2013
- Author(s)
  Tetsuo Kobayashi
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  奈良県新公会堂（奈良県）
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] Improvement of periodontal condition by anti-tumor necrosis factor therapy in rheumatoid arthritis patients2012
- Author(s)
  Kobayashi T
- Organizer
  EuroPerio 7
- Place of Presentation
  Vienna, Austria
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] 抗TNF療法による関節リウマチ患者の歯周組織状態への影響2012
- Author(s)
  小林哲夫
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] Improvement of periodontal condition by anti-tumor necrosis factor therapy in rheumatoid arthritis patients2012
- Author(s)
  Kobayashi T
- Organizer
  EuroPerio 7
- Place of Presentation
  Vienna, Austria.
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] Effects of Anti-Tumor Necrosis Factor Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis2012
- Author(s)
  Kobayashi T
- Organizer
  The 52nd. Annual Scientific Meeting of the Korean Academy of Periodontology
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] 抗TNF療法による関節リウマチ患者の歯周組織状態の改善2012
- Author(s)
  小林哲夫
- Organizer
  第55回春季日本歯周病学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] 関節リウマチにおける歯周炎関連タンパク質の網羅的解析2011
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2011年度春季学術大会(第134回)
- Place of Presentation
  浦安
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] Serum cytokine and periodontal profiles related to rheumatoid arthritis activity2010
- Author(s)
  Kobayashi T
- Organizer
  The 96th. Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
- Place of Presentation
  Honolulu, Hawaii, United States of America
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] Serum cytokine and periodontal profiles related to rheumatoid arthritis activity2010
- Author(s)
  Kobayashi T
- Organizer
  The 96th. Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
- Place of Presentation
  Honolulu, USA.
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-22390396
[Presentation] 関節リウマチ活動度と歯周疾患重症度との関連性2009
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2009年度秋季学術大会(第131回)
- Place of Presentation
  仙台
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-19390535
[Presentation] 関節リウマチ活動度と歯周疾患重症度との関連性2009
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2009年度秋季学術大会(第131回)
- Place of Presentation
  仙台
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型2009
- Author(s)
  小林哲夫
- Organizer
  第52回春季日本歯周病学会学術大会
- Place of Presentation
  岡山
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19390535
[Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型2009
- Author(s)
  小林哲夫
- Organizer
  第52回春季日本歯周病学会学術大会
- Place of Presentation
  岡山市岡山コンベンションセンター
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型2009
- Author(s)
  小林哲夫
- Organizer
  第52回春季日本歯周病学会学術大会
- Place of Presentation
  岡山市岡山コンベンションセンター
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19390535
[Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型2009
- Author(s)
  小林哲夫
- Organizer
  第52回春季日本歯周病学会学術大会
- Place of Presentation
  岡山.
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] Gene Polymorphisms in Rheumatoid Arthritis and Periodontitis in Japanese2008
- Author(s)
  Kobayashi T
- Organizer
  The 4th Pan European Federation of International Association for Dental Research
- Place of Presentation
  London
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19390535
[Presentation] Gene Polymorphisms in Rheumatoid Arthritis and Periodontitis in Japanese2008
- Author(s)
  Kobayashi T
- Organizer
  The 4th Pan European Federation of International Association for Dental Research
- Place of Presentation
  London
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] Gene polymorphisms in rheumatoid arthritis and periodontitis in Japanese2008
- Author(s)
  Tetsuo Kobayashi
- Organizer
  The 4th Pan European Federation of International Association for Dental Research
- Place of Presentation
  London, UK
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] Gene polymorphisms in rheumatoid arthritis and periodontitis in Japanese2008
- Author(s)
  Tetsuo Kobayashi
- Organizer
  The 4th Pan European Federation of International Association for Dental Research
- Place of Presentation
  London, UK
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19390535
[Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis2007
- Author(s)
  KobayashiT
- Organizer
  The 93rd. Annual Meeting of the Aerican Academy of Periodontology
- Place of Presentation
  Washington DC
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-19390535
[Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis2007
- Author(s)
  Kobayashi T
- Organizer
  The 93rd. Annual Meeting of the Aerican Academy of Periodontology
- Place of Presentation
  Washington DC
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis2007
- Author(s)
  Tetsuo Kobayashi
- Organizer
  The 93rd. Annual Meeting of the American Academy of Periodontology
- Place of Presentation
  Washington DC, USA
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-19592383
[Presentation] 抗ＴＮＦ療法による関節リウマチ患者の歯周組織状態の改善
- Author(s)
  小林哲夫
- Organizer
  第５５回春季日本歯周病学会学術大会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] Improvement of periodontal condition by anti-tumor necrosis factor therapy in rheumatoid arthritis patients
- Author(s)
  Tetsuo Kobayashi
- Organizer
  EuroPerio 7
- Place of Presentation
  メッセ・ウィーンエキシビションセンター（ウィーン）
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] IL-6受容体抑制治療中の関節リウマチ患者の歯周状態
- Author(s)
  小林哲夫
- Organizer
  第５６回春季日本歯周病学会学術大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] Tumor Necrosis Factor-Alpha Gene Promoter Methylation in Chronic Periodontitis.
- Author(s)
  Kojima A, Kobayashi T, Ishida K, Okada M, Yoshie H.:
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  奈良県新公会堂（奈良市）
- Year and Date
  2013-09-03 – 2013-09-04
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] Interkeukin-6 Gene Promoter Methylation in Periodontal Tissues.
- Author(s)
  Ishida K, Kobayashi T, Yokoyama T, Okada M, Kojima A, Yoshie H.: Interkeukin-6
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  奈良県新公会堂（奈良市）
- Year and Date
  2013-09-03 – 2013-09-04
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] トシリズマブ（TCZ）療法中の関節リウマチ患者の歯周状態
- Author(s)
  小林哲夫
- Organizer
  第５７回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] 関節リウマチ患者におけるトシリズマブ治療の歯周状態への影響
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2013年度春季学術大会（第138回）
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] Effects of Periodontal Treatment on Antibodies to Porphyromonas gingivalis and Citrulline levels and Rheumatoid Arthritis Condition
- Author(s)
  Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A, Yoshie H
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  奈良県新公会堂（奈良市）
- Year and Date
  2013-09-03 – 2013-09-04
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 関節リウマチ患者におけるトシリズマブ治療の歯周状態への影響
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2013年度春季学術大会（第138回）
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] IL-6受容体抑制治療中の関節リウマチ患者の歯周状態
- Author(s)
  小林哲夫
- Organizer
  第５６回春季日本歯周病学会学術大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] トシリズマブ（TCZ）療法中の関節リウマチ患者の歯周状態
- Author(s)
  小林哲夫
- Organizer
  第５７回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] Effect of Interkeukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Periodontitis.
- Author(s)
  Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H.
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  奈良県新公会堂（奈良市）
- Year and Date
  2013-09-03 – 2013-09-04
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] Effect of Interkeukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Periodontitis
- Author(s)
  小林哲夫
- Organizer
  The 10th. Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  奈良県新公会堂（奈良県）
- Data Source
  KAKENHI-PROJECT-24659922
[Presentation] 抗ＴＮＦ療法による関節リウマチ患者の歯周組織状態の改善
- Author(s)
  小林哲夫
- Organizer
  第５５回春季日本歯周病学会学術大会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-22592309
[Presentation] 関節リウマチにおける歯周炎関連タンパク質の網羅的解析
- Author(s)
  小林哲夫
- Organizer
  日本歯科保存学会2011年度春季学術大会（第134回）
- Place of Presentation
  東京ベイ舞浜ホテルクラブリゾート（千葉県舞浜市）
- Data Source
  KAKENHI-PROJECT-22592309

1. YOSHIE Hiromasa (20143787)

# of Collaborated Projects: 11 results

# of Collaborated Products: 61 results
2. SUGITA Noriko (30313547)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
3. YAMAMOTO Kouji (00397142)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
4. TAI Hideaki (30272826)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. NARITA Ichiei (20272817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. KUBOTA Takehiko (50303136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. FUJITA Hajime (60271805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. TAKAGI Ritsuo (20143795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. HOSHINA Hideyuki (30173587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. NAGATA Masaki (10242439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. KOMATSU Yasutaka (40422597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
12. HARA Kohji (20018419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TAKEUCHI Yoshiharu (10236440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAZAKI Kazuhisa (00182478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAWAGUCHI Hiroyuki (10224750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OSHIMA Mitsuhiro (30194145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ABIKO Yoshimitsu (70050086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. UMEDA Makoto (90193937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KAWABATA Yoshikatsu (80329490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KURODA Takeshi (00372475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高柴正悟 (50226768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 永田俊彦 (10127847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 三谷章雄 (50329611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
24. 石原裕一 (50261011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
25. 木戸淳一 (10195315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 大森一弘 (20549860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. 前田博史 (00274001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. 野口俊英 (50014262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
29. 青柳昌子 (40251839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 鈴木卓 (00251827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 伊藤聡 (00334681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. SHIBATA Yasuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. NISHIDA Eisaku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. HASEGAWA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 菊池毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
36. 小澤佑介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 西原達次

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. 安孫子宜光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 相野誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Tetsuo 小林 哲夫

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Analysis of the role of carbamylated peptide and NET for the association between periodontitis and rheumatoid arthritisPrincipal InvestigatorOngoing

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A profiling of citrullination in relation to shared mechanisms in periodontitis and rheumatoid arthritisPrincipal Investigator

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Analysis of Genome Methylation Profile in Relation to Common Mechanisms of Periodontitis and Rhematoid Arthritis OnsetPrincipal Investigator

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The role of Fc receptor genes in regulation of signal expression associated with susceptibility to periodontitisPrincipal Investigator

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The genome wide scan analysis system for periodontal diseases susceptible genesPrincipal Investigator

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Determination of common risk genes associated with periodontitis and autoimmune diseasePrincipal Investigator

KOBAYASHI Tetsuo 小林哲夫