ISHIHARA Yuichi 石原裕一

Researcher Number	50261011
Other IDs
External Links
Affiliation (Current)	2025: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長
Affiliation (based on the past Project Information) *help	2019 – 2025: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長 2023: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 室長 2013 – 2018: 松本歯科大学, 歯学部, 教授 2007 – 2013: Aichi Gakuin University, 歯学部, 准教授 2000 – 2006: 愛知学院大学, 歯学部, 講師 1994 – 1999: 愛知学院大学, 歯学部, 助手 1998: 助手
Review Section/Research Field	Principal Investigator Periodontal dentistry / Conservative dentistry / Basic Section 57030:Conservative dentistry-related / Periodontal dentistry / Periodontology / 病態科学系歯学(含放射線系歯学) Except Principal Investigator Periodontal dentistry / Basic Section 57030:Conservative dentistry-related / Basic Section 57080:Social dentistry-related / Ophthalmology … More / Periodontal dentistry / Conservative dentistry / Morphological basic dentistry / Periodontology Less
Keywords	Principal Investigator IL-1 / 歯肉溝滲出液 / 歯周病 / インターロイキン-1 / Actinobacillus actinomycetemcomitans / LPS / 実験的歯周炎 / TIMP / 破骨細胞 / ELISA … More / gingival crevicular fluid / IL-1β / 早期発症型歯周炎 / juvenile periodontitis / IL-1Ra / インターロイキンー１ / 炎症性骨吸収 / 侵襲性歯周炎 / インターロイキン1 / インターロイキン-1レセプターアンタゴニスト / 定期的口腔管理 / 栄養摂取 / 口腔機能 / 口腔機能訓練体操 / 口腔機能低下 / 舌圧 / 反復唾液嚥下 / 舌口唇運動機能 / 咬合力 / 軽度認知機能低下 / 臨床的認知症尺度 / プラークコントロールレコード / 現在歯数 / MMSE / MCI / 認知症 / 血液検査 / インターロイキンー1受容体補助タンパク / 歯周病検査 / 血清 / IL-1RAcP / 高感度CRP / 可溶性IL-1受容体補助タンパク質 / 血清マーカー / sIL-1RAcP / インターロイキン１レセプターアンタゴニスト / インターロイキン１ / 歯周治療 / インターロイキンレセプターアンタゴニスト / 高脂血症治療薬 / クロフィブラート / aggressive periodontitis / interleukin-1β / chronic periodontitis / soluble interleuklin-1receptor type 2 / IL-1receptor type2 / 慢性歯周炎 / IL-1receptor type 2 / HGF / periodontitis / interleukin-8 / interleukin-6 / polysaccharide / Actinobacillus actinomycetemcomitans_ / リポ多糖 / Interleukin-8 / 歯肉線維芽細胞 / A.actinomycetemcomitans / OIP-1 / Interleukin-6 / 血清抗体価 / 樹状細胞 / 莢膜多糖抗原 / peripheral blood lymphocyte / Interleukin-1 / adult periodontitis / rapidly progressive periodontitis / IL-1α / 成人性歯周炎 / IL-1ra / osteoclast-like cell / マウス骨髄細胞培養系 / マウス骨髄培養系 / 若年性歯周炎 / RNA干渉 / 接着分子 / 骨芽細胞 / 骨関連遺伝子 / IL-6 / TNF-α / A. actinomycetemcomitans / 骨吸収因子 / 遺伝子欠損マウス / インターロイキンー１Ra / 歯周治療薬 / サイトカイン / 遺伝子改変マウス / インターロイキンー１レセプターアンタゴニスト / Tepe II IL-1 receptor / 破骨細胞形成 / ELISA法 / IL-1 receptor antagonist / Type II IL-1 receptor / IL-1Ra KOマウス / 実験的歯周炎モデル / 炎症性サイトカイン / IL-1Ra欠損マウス / インターロイキン-1タイプIIレセプター / 歯周免疫機能学 / インターロイキン-1β / インターフェロンーγ / インターロイキンー4 / マウス歯肉上皮細胞 / 遺伝子多型 / 可溶性IL-1タイプ2レセプター / インターロイキンー1β / 可溶性インターロイキンー1タイプ2レセプター / インターロイキンー1 / 歯肉溝浸出液 / インターロイキン1レセプターアンタゴニニスト / GCF / 急速進行性歯周炎 / インターロイキン1レセプターアンタゴニスト / 骨髄細胞培養系 / インターロイキン-1ra … More Except Principal Investigator 歯周病 / 動脈硬化症 / 破骨細胞 / 糖尿病 / 歯周炎 / 抗老化細胞療法 / IFN-γ / OIP-1 / Th1 / IL-15 / periodontal disease / interleukin-1 / 骨吸収 / Actinobacillus actinomycetemcomitans / Porphyromonas gingivalis / 歯学 / 歯周病関連細菌 / 口腔細菌叢 / 口腔ケア / プロバイオティクス / 行動実験 / 認知症 / BPSD / アルツハイマー病 / 包括治療法 / 慢性炎症 / 歯周治療 / 骨代謝 / スクレロスチン / 分子基盤 / 老化制御 / 眼科 / 外科 / 動脈硬化 / 脈絡膜新生血管 / 加齢黄斑変性 / gene expression / microarray / restraint stress / experimental periodontitis / 遺伝子発現 / マイクロアレイ / 拘束ストレス / 実験的歯周炎 / bisphosphonate / fractal dimension / community periodontal index / bone mineral density / osteoporosis / ビスフォスフォネート / フラクタル次元 / 地域歯周疾患指数 / 骨密度 / 骨粗鬆症 / Osteoclast / Bone resorption / Periodontitis / IL-1β / γδT cell / Mucosal infection / 上皮系サイトカイン / γδT細胞 / 粘膜感染 / prostagrandin / bone nesorption / capsular polysaccharide / Actinobocillus actinomycetemcomitans / 若年性歯周炎 / インターロイキン1レセプターアンタゴニスト / インターロイキン1 / プロスタグランディン / 莢膜多糖 / 歯周疾患 / 代謝 / 酪酸 / 短鎖脂肪酸 / 関節リウマチ / サイトカイン遺伝子 / プラーク細菌 / う蝕細菌 / ゲノム解析 / 16SrRNA解析 / 臨床株 / プラーク細菌叢 / IL-17 / 免疫学 / Th17 / 歯周組織 / IL-35 / 16SrRNA遺伝子解析 / 歯肉縁下プラーク / 歯肉縁上プラーク / ゲノムDNA抽出 / メタゲノム解析 Less

The practice of ICT-applied Kami kami Goku Goku Exercise contributes to the maintenance and improvement of oral functions of the elderlyPrincipal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  The Lion Foundation for Dental Health
Development of a new comprehensive treatment for periodontal disease, diabetes and atherosclerosis with senescent cell therapeutics.
- Principal Investigator
  
  吉成伸夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Matsumoto Dental University
歯周病菌とアルツハイマー病周辺症状の関連性とその制御に関する総合的研究
- Principal Investigator
  
  松下健二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Ogaki Women's College
  National Center for Geriatrics and Gerontology
高齢者認知機能低下に係る歯周病病態、口腔細菌および口腔機能の影響についての研究Principal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  The Lion Foundation for Dental Health
慢性炎症が基盤病態の歯周病，糖尿病，動脈硬化症に対する抗老化細胞療法の創出
- Principal Investigator
  
  吉成伸夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Matsumoto Dental University
Development of a potential new marker of periodontal disease status based on serum IL-1 receptor accessory protein .Principal Investigator
- Principal Investigator
  
  Ishihara Yuichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  The Lion Foundation for Dental Health
Elucidation of molecular basis for the relationship between periodontal disease and atherosclerosis by controlling aging
- Principal Investigator
  
  Yoshinari Nobuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Matsumoto Dental University
Development of the new periodontal treatments based on the regulation of sclerostin secretion
- Principal Investigator
  
  Koide Masanori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Matsumoto Dental University
Association subtype of age-relrated macular degeneration and periodontal disease
- Principal Investigator
  
  Ohta Kouichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Matsumoto Dental University
Clofibrate produce IL-1Ra and inhibit the experimental periodontitisPrincipal Investigator
- Principal Investigator
  
  Ishihara Yuichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Matsumoto Dental University
Elucidation and control of effect of short chain fatty acids on periodontopathogens
- Principal Investigator
  
  Yoshida Yasuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Aichi Gakuin University
An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
The role of IL-35 on Th17 cells in inflamed gingiva
- Principal Investigator
  
  MITANI Akio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Genome sequencing of clinical strains isolated from dental plaque for investigation of polymicrobial factors in periodontal pathogenesis
- Principal Investigator
  
  HAYASHI Jun-ichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Effect of IL-1Ra in periodontal tissue destruction with IL-1Ra-deficient micePrincipal Investigator
- Principal Investigator
  
  ISHIHARA YUICHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Matsumoto Dental University
  Aichi Gakuin University
Effect of the IL-1 typeIIreceptor to a experimental periodontitis infected with periodontal bacteriumPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Metagenomic Analysis of Oral Microbiota from Normal Subjects and Patients with Periodontal Disease
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
A function of soluble Interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Efficacy of therapy for osteoporosis on oral health
- Principal Investigator
  
  INAGAKI Koji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin Unviersity
The roll of soluble interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin university
Effect of restraint stress on the gene expression in periodontal tissue of rat experimental periodontitis
- Principal Investigator
  
  YOSHINARI Nobuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin University
The working mechanism of bone resorption inhibitory protein induced by osteoclasts
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin University
The effects of the role of cytokine stimulated capsular polysaccharide Actinobacillus actinomycetemcomitans in human gingival fibroblast and monocyte.Principal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Aichi-Gakuin University
The investigation of the role of cytokine from derived epithelial cell for activation γδ T cells in mucosal infection
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin University
The specificity of cytokine production from inflammatory gingivaPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
The effect of TIMP on bone resorption and osteoclast like cell formation induced by juvenile periodontitis related bacteriaPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi, 上田信男
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-gakuin University
歯周炎患者における歯周組織中のIL-1の相互作用についてPrincipal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University
マウス骨髄細胞培養系による破骨細胞形成に対するTIMPの役割についてPrincipal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University
Cell-surface components Actinobacillus actinomycetemcomitans promote osteoclast formation in vitro
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi-gakuin University
歯周炎患者の歯肉溝滲出液中のIL-1とIL-1raの動態に関する研究Principal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University
歯周炎患者の歯肉溝滲出液中のIL-1とIL-1raの動態に関する研究Principal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University

[Journal Article] Cross-Sectional Analysis of Periodontal Disease and Cognitive Impairment Conducted in a Memory Clinic: The Pearl Study2023
- Author(s)
  N. Saji, Y. Ishihara, K. Murotani, A. Uchiyama, A. Takeda, T. Sakurai, K. Matsushitaf
- Journal Title
  
  J Alzheimers Dis .
  
  Volume: 96 Issue: 1 Pages: 369-380
- DOI
  10.3233/jad-230742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10011, KAKENHI-PROJECT-20H03904
[Journal Article] The Regulation of Bone Metabolism and Disorders by Wnt Signaling.2019
- Author(s)
  Maeda K, Kobayashi Y, Koide M, Uehara S, Okamoto M, Ishihara A, Kayama T, Saito M, Marumo K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Issue: 22 Pages: 5525-5525
- DOI
  10.3390/ijms20225525
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10050, KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-18K16161, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-18H02980, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-17K16706
[Journal Article] The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study.2018
- Author(s)
  Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
- Journal Title
  
  J Periodontol
  
  Volume: 89(3) Issue: 3 Pages: 315-324
- DOI
  10.1002/jper.17-0412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K11983, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15764
[Journal Article] Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice2017
- Author(s)
  Ishida N, Ishihara Y, Ishida K, Tada H, Funaki-Kato Y, Hagiwara M, Ferdous T, Abdullah M, Mitani A, Michikawa M, Matsushita K.
- Journal Title
  
  NPJ Aging Mech. Dis.
  
  Volume: 3 Issue: 1 Pages: 15-15
- DOI
  10.1038/s41514-017-0015-x
- NAID
  120006576159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11824, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K17362, KAKENHI-PROJECT-26293438, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15712, KAKENHI-PROJECT-26861586, KAKENHI-PROJECT-16H05559
[Journal Article] Increased Expression of Interleukin-35 and -17, but not -27, in Gingival Tissues with Chronic Periodontitis.2015
- Author(s)
  Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T.
- Journal Title
  
  J Periodontol
  
  Volume: 86 Pages: 301-309
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Adhesion Properties of Human Oral Epithelial-Derived Cells to Zirconia.2015
- Author(s)
  Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Sasaki K, Ban S, Noguchi T, Kawai T, Mitani A.
- Journal Title
  
  Clin Implant Dent Relat Res.
  
  Volume: 10 Issue: 5 Pages: 906-916
- DOI
  10.1111/cid.12369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-26463149
[Journal Article] Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.2015
- Author(s)
  Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 10 Pages: e0140942-e0140942
- DOI
  10.1371/journal.pone.0140942
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-26463149, KAKENHI-PROJECT-25253104
[Journal Article] Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis2015
- Author(s)
  Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T
- Journal Title
  
  J Periodontol
  
  Volume: 86 Issue: 2 Pages: 301-309
- DOI
  10.1902/jop.2014.140293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134
[Journal Article] TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1.2014
- Author(s)
  Kato Y, Hagiwara M, Ishihara Y, Isoda R, Sugiura S, Komatsu T, Ishida N, Noguchi T, Matsushita K.
- Journal Title
  
  BMC Microbiology
  
  Volume: 14 Pages: 229-229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] IL-1 Receptor Type II Production Is Upregulated by IL-4 and IL-13, and Downregulated by IFN-γ in Mouse Gingival Epithelial Cells2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T
- Journal Title
  
  Modern Research in Inflammation
  
  Volume: 3 Issue: 02 Pages: 37-47
- DOI
  10.4236/mri.2014.32005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593137
[Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in Japanese.2014
- Author(s)
  Kamei H, Ishihara Y, Fuma D, Niwa T, Kamiya Y, Yokoi T, Suzuki M, Izawa A, Mizutani H, Hayashi J, Sakaki Y, Noguchi T, Kojima T.
- Journal Title
  
  Arch. Oral Biol.
  
  Volume: 59 Pages: 756-763
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture.2014
- Author(s)
  Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
- Journal Title
  
  Inflammation
  
  Volume: 37 Pages: 657-669
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
- Journal Title
  
  Modern Research in Inflammation
  
  Volume: 3 Pages: 37-47
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24593137
[Journal Article] IL-1ファミリーとIL-1受容体：歯周病疾患マーカーや治療薬としての可能性2014
- Author(s)
  石原裕一，亀井英彦，神谷洋介，伊澤有郎，水谷大樹，鈴木万里代，野口俊英，三谷章雄
- Journal Title
  
  日歯周誌
  
  Volume: 56 Pages: 272-280
- NAID
  130004842577
- Data Source
  KAKENHI-PROJECT-24593137
[Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese2014
- Author(s)
  Kamei H、Ishihara Y, 12 others
- Journal Title
  
  Arch Oral Biol
  
  Volume: Vol. 59、No. 7 Issue: 7 Pages: 756-763
- DOI
  10.1016/j.archoralbio.2014.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593079, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-25870860
[Journal Article] Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in IL-1Ra knockout mice.2014
- Author(s)
  Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J, Nishihara T, Maeda H, Noguchi T.
- Journal Title
  
  Infect Immun
  
  Volume: 82 Issue: 5 Pages: 1904-1913
- DOI
  10.1128/iai.01618-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463149
[Journal Article] Effect of IL-15 and natural killer cells on osteoclast and osteoblast in a mouse coculture2014
- Author(s)
  Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T
- Journal Title
  
  Inflammation
  
  Volume: 37 Issue: 3 Pages: 657-669
- DOI
  10.1007/s10753-013-9782-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-26463149
[Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells.2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
- Journal Title
  
  Modern Research in Inflammation
  
  Volume: 3 Pages: 37-47
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Lipopolysaccharide of Aggregatibacter actinomycetemcomitans up-regulates inflammatory cytokines, prostaglandin E2 synthesis and osteoclast formation in interleukin-1 receptor antagonist-deficient mice2013
- Author(s)
  Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T.
- Journal Title
  
  J Periodont Res
  
  Volume: 48 Issue: 6 Pages: 748-756
- DOI
  10.1111/jre.12065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-25253104
[Journal Article] Effect of IL-15 and natural killer cells on osteoclast and osteoblast in a mouse coculture2013
- Author(s)
  Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
- Journal Title
  
  Inflammation
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593134
[Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates T cell activation2013
- Author(s)
  Suga T, Mitani A, Mogi M, Kikuchi T, Fujimura T, Takeda H, Hishikawa T, Yamamoto G, Hayashi J, Ishihara Y, Noguchi T.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 58 Issue: 10 Pages: 1541-1548
- DOI
  10.1016/j.archoralbio.2013.06.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593134
[Journal Article] Valproic Acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 12011
- Author(s)
  Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
- Journal Title
  
  Shock
  
  Volume: 36 Pages: 494-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592638
[Journal Article] Degradation of vascular endothelial thrombomodulin by arginine-and lysin-specific cysteine proteases from Porphyromonas gingivalis.2009
- Author(s)
  Inomata M, Ishihara Y, Matsuyama T, Murayama I, Noguchi T, Matsushita K.
- Journal Title
  
  J.Periodontol. 8
  
  Pages: 1511-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249082
[Journal Article] Degradation of vascular endothelial thrombomodulin by arginine-and lysin-specific cysteine proteases from Porphyromonas gingivalis2009
- Author(s)
  Inomata M, Ishihara Y, Matsuyama T, Murayama I, Noguchi T, Matsushita K
- Journal Title
  
  J.Periodontol. 80
  
  Pages: 1511-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249082
[Journal Article] Soluble Interleukin-1 Receptor Type II Levels in Gingival Crevicular Fluid in Aggressive and Chronic Periodontitis2008
- Author(s)
  Suzuki M, Ishihara.Y, Kamei H, 10名
- Journal Title
  
  J Periodontol 79巻
  
  Pages: 495-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592397
[Journal Article] TIMP-1およびTIMP-2は破骨細胞形成を促進する2005
- Author(s)
  祖父江尊範, 小出雅則, 石原裕一, 野口俊英
- Journal Title
  
  日本歯周病学会誌 47(4)
  
  Pages: 297-308
- NAID
  10016919077
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390648
[Journal Article] Actinobacillus actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells.2005
- Author(s)
  Iwata T, Mitani A, Ishihara Y et al.
- Journal Title
  
  Clin Exp Immuno 141
  
  Pages: 261-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Actinobacillus actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells2005
- Author(s)
  Iwata T, Mitani A, Ishihara Y et al.
- Journal Title
  
  Clin Exp Immuno 141
  
  Pages: 261-269
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] A.actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells2005
- Author(s)
  Iwata T, Mitani A, Ishihara Y, Koide M, Sobue T, Noguchi T
- Journal Title
  
  Clin Exp Immuno 141
  
  Pages: 261-269
- Data Source
  KAKENHI-PROJECT-15390648
[Journal Article] Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response.2004
- Author(s)
  Al-Darmaki S, Knightshead K, Ishihara Y, et al.
- Journal Title
  
  Clin Diagn Lab Immunol 11
  
  Pages: 720-728
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6 Zr alloy against MG63 osteoblast like cell.2004
- Author(s)
  Naganawa T, Ishihara Y, Iwata T. et al.
- Journal Title
  
  J Periodontol 75・12
  
  Pages: 1701-1707
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1 beta in gingival crevicular fluid and gingival tissue.2004
- Author(s)
  Yoshinari N, Kawase H, Mitani M, Shirozu N., Ishihara
- Journal Title
  
  J Periodontal Res 39・3
  
  Pages: 158-167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1β in gingival crevicular fluid and gingival tissues.2004
- Author(s)
  Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T.
- Journal Title
  
  Journal of Periodontal Research 39
  
  Pages: 158-167
- Data Source
  KAKENHI-PROJECT-16592083
[Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6Zr alloy against MG63 osteoblast like cell.2004
- Author(s)
  Naganawa T, Ishihara Y, Iwata T. et al.
- Journal Title
  
  J Periodontol 75
  
  Pages: 1701-1707
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] 閉経が歯肉溝滲出液中のインターロイキン・1濃度に及ぼす影響2004
- Author(s)
  夫馬大介, 稲垣幸司, 石原裕一他
- Journal Title
  
  日歯周誌 46・4
  
  Pages: 259-265
- NAID
  10014078774
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effect of Menopause on Interleukin-1 Concentration in Gingival Crevicular Fluids2004
- Author(s)
  Fuma D, Inagaki K, Ishihara Y et al.
- Journal Title
  
  J Jpn Soc Periodontol 46
  
  Pages: 259-265
- NAID
  10014078774
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues.2004
- Author(s)
  Yoshinari N, Kawase H, Mitani M, Shirozu N, Ishihara Y et al.
- Journal Title
  
  J Periodontal Res 39・3
  
  Pages: 158-167
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6Zr alloy against MG63 osteoblast like cell.2004
- Author(s)
  Naganawa T, Ishihara Y, Iwata T. et al.
- Journal Title
  
  J Periodontol 75・12
  
  Pages: 1701-1707
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] 閉経が歯肉溝滲出液中のインターロイキン-1濃度に及ぼす影響2004
- Author(s)
  夫馬大介, 稲垣幸司, 石原祐一他
- Journal Title
  
  日歯周誌 46・4
  
  Pages: 259-265
- NAID
  10014078774
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Delineation of the Role of Platelet-Activating Factor in the Immunoglobulin G2 Antibody Response.2004
- Author(s)
  Al-Darmaki S, Knightshead K, Ishihara Y et al.
- Journal Title
  
  Clin Diagn Lab Immunol 11
  
  Pages: 720-728
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Capsular polysaccharide from Actiaobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast.2003
- Author(s)
  Ohguchi Y, Ishihara Y, Koide M, Noguchi T. et al.
- Journal Title
  
  J Periodont Res 38(2)
  
  Pages: 191-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390648
[Journal Article] Capsular polysaccharide from Actinobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast.2003
- Author(s)
  Ohguchi Y, Ishihara Y, Koide M, Noguchi T.
- Journal Title
  
  J Periodont Res 38(2)
  
  Pages: 191-197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390648
[Presentation] もの忘れ外来患者の認知機能は口腔清掃状態と相関する2023
- Author(s)
  湯之上志保、石原裕一、武儀山みさき、細久保和美、伊土美南海、野原佳織、新明桃、内山章、松下健二
- Organizer
  第72回日本口腔衛生学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10011
[Presentation] 認知症者では歯科受診が少なく歯周病が重度である：もの忘れ外来での歯科検診研究2023
- Author(s)
  佐治直樹、石原裕一、室谷健太、内山章、武田章敬、櫻井孝、松下健二
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K10011
[Presentation] 口腔機能低下と歯周病病態との関連性―もの忘れ外来患者を対象とした観察研究(2)―2022
- Author(s)
  伊土;美南海、石原裕一、新明桃、湯之上志保、武儀山みさき、細久保和美、與那覇佳織、古川匡恵、内山章、佐治直樹、松下健二
- Organizer
  第65回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10011
[Presentation] 認知症者では歯磨きの回数や時間が少ない：もの忘れ外来での歯科検診研究2022
- Author(s)
  佐治直樹、石原裕一、内山章、室谷健太、武田章敬、櫻井孝、松下健二
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-22K10011
[Presentation] 認知機能低下および認知症と歯周病病態との関連性―もの忘れ外来患者を対象とした観察研究（１）―2022
- Author(s)
  石原裕一、新明桃、與那覇佳織、湯之上志保、武儀山みさき、細久保和美、伊土美南海、古川匡恵、内山章、佐治直樹、松下健二
- Organizer
  第65回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10011
[Presentation] 口腔機能低下と認知機能の関連性―もの忘れ外来患者を対象とした観察研究(3) ―2022
- Author(s)
  新明桃、石原裕一、伊土美南海、湯之上志保、武儀山みさき、細久保和美、與那覇佳織、古川匡恵、内山章、佐治直樹、松下健二
- Organizer
  第65回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10011
[Presentation] 破骨細胞由来のLIFは,sclerostin発現を低下させて骨形成を促進する2018
- Author(s)
  小出雅則, 尾崎友輝, 中村圭吾, 宇田川信之, 石原裕一, 吉成伸夫
- Organizer
  日本歯周病学会会誌(Web)
- Data Source
  KAKENHI-PROJECT-18H02980
[Presentation] 歯周組織におけるIL-1Raの役割と治療薬への可能性2017
- Author(s)
  石原裕一
- Organizer
  60回春季日本歯周病学会学術大会学会学術賞記念講演
- Invited
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] IL-1Ra欠損マウスでの破骨細胞形成と炎症性骨吸収が亢進する2017
- Author(s)
  石原裕一，小出雅則，吉成伸夫
- Organizer
  第2回日本骨免疫学会ウインターセミナ
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] IL-1Ra欠損マウスでは破骨細胞形成と炎症性骨吸収が亢進する2017
- Author(s)
  石原裕一，小出雅則，吉成伸夫
- Organizer
  第２回日本骨免疫学会ウインターセミナー
- Place of Presentation
  ホテルマロウド軽井沢（長野）
- Year and Date
  2017-01-27
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] The Effect of Serum Amyloid A for Endothelial Cell2016
- Author(s)
  Yoshinari,N., Takahashi K., Kaise K., Saleem M., Ozaki Y., Nakamura S., Kubokawa K., Ishihara Y.
- Organizer
  94th General session of the IADR
- Place of Presentation
  Seoul　(Korea)
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] 骨吸収はsclerostinの発現低下を介して骨形成を促進する2016
- Author(s)
  小出雅則、尾崎友輝、吉成伸夫、石原裕一、宇田川信之
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  鹿児島県民交流センター(鹿児島)
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] ジルコニアに対するヒト口腔由来上皮細胞の付着特性2015
- Author(s)
  郎，石原裕一，菊池　毅，伊澤有郎，小林周一郎，後藤久嗣，神谷洋介，伴　清治，野口俊英，河合逹志，三谷章雄
- Organizer
  第58回秋季日本歯周病学会学術大会
- Place of Presentation
  浜松アクトシティ浜松
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] Adhesion properties of human oral epithelial-derived cells to zirconia2015
- Author(s)
  Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Ban S, Noguchi T, Kawai T and Mitani A
- Organizer
  第63回国際歯科研究会日本部会総会・学術総会
- Place of Presentation
  福岡　福岡国際会議場
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する.2014
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英，三谷章雄
- Organizer
  秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場(兵庫)
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
- Organizer
  2014 Annual Meeting of American Academy of Periodontology
- Place of Presentation
  Moscone center, San Francisco, USA
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する2014
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英，三谷章雄
- Organizer
  第57回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
- Organizer
  the 100th Annual Meeting of American Academy of Periodontology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients2014
- Author(s)
  Yosuke Kamiya, Yuichi Ishihara, Hidehiko Kamei, Ario Izawa, Eijiro Okabe, Hisashi Goto, Akane Kuno, Yuji Sugawa, Yusuke Ozawa, Akio Mitani
- Organizer
  2014 Annual Meeting of American Academy of Periodontology
- Place of Presentation
  San Francisco
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] インターロイキン１レセプターアンタゴニストのコラゲナーゼ３(MMP-13)発現抑制について2014
- Author(s)
  後藤久嗣、石原裕一、伊澤有郎、岡部栄次郎、久保勝俊、杉田好彦、前田初彦、野口俊英、三谷章雄
- Organizer
  第85回愛知学院大学歯学会
- Place of Presentation
  愛知学院大学楠元キャンパス(愛知)
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] Interleukin-1 receptor antagonistは歯肉上皮細胞からのMatrix metalo- peptidase 13発現を抑制する2014
- Author(s)
  後藤久嗣,　石原裕一,　伊澤有郎,　岡部栄治郎,　久保勝俊,　杉田好彦,　前田初彦,　野口俊英, 三谷章雄
- Organizer
  第57回秋季日本歯周病学会
- Place of Presentation
  神戸
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] 垂直性骨欠損に対し GTR 法とエナメルマトリックスタンパク質を用いた歯周組織再生療法を行った症例の 5 年経過時における臨床的比較2013
- Author(s)
  相野誠, 三谷章雄, 高須英成, 古田英豊, 永坂太郎, 三輪晃資, 菊池毅, 川瀬仁史, 伊藤正満, 林潤一郎, 黒須康成,石原裕一, 稲垣幸司, 福田光男, 野口俊英.
- Organizer
  日本歯科保存学会春期学術大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響2013
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第56回秋季日本歯周病学会
- Place of Presentation
  前橋市市民文化会館（前橋市）
- Year and Date
  2013-09-22
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] 歯周病関連細菌Porphyromonas gingivalisの歯肉上皮細胞への侵入機構の解明2011
- Author(s)
  加藤佳子, 杉浦進介, 小松寿明, 石原裕一, 野口俊英, 松下健二
- Organizer
  第54回春季日本歯周病学会
- Place of Presentation
  福岡
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウスを用いたA. actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現2011
- Author(s)
  伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] ヒト歯周病細菌叢のメタゲノム解析2011
- Author(s)
  林潤一郎,近藤伸二、亀井英彦、森田英利、足立直樹、福田光男、Todd D Taylor、石原裕一、小島俊男、野口俊英
- Organizer
  第5回日本ゲノム微生物学会
- Place of Presentation
  仙台
- Year and Date
  2011-03-14
- Data Source
  KAKENHI-PROJECT-20249082
[Presentation] プラーク細菌叢のメタゲノム解析2011
- Author(s)
  林潤一郎、亀井英彦、福田光男、石原裕一、野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウスを用いたA.actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現2011
- Author(s)
  伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウスの破骨細胞形成能と実験的歯周炎について2011
- Author(s)
  石原裕一, 水谷大樹, 伊澤有郎, 三谷章雄, 黒須康成, 川瀬仁史, 稲垣幸司, 野口俊英
- Organizer
  第135回日本歯科保存学会秋季学術大会
- Place of Presentation
  大阪
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウス腹腔マクロファージにおける骨吸収活性の解析2011
- Author(s)
  水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 久保勝俊, 西原達次, 前田初彦, 野口俊英
- Organizer
  第3回口腔先端応用医科学研究会
- Place of Presentation
  東京
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1RaKOマウス腹腔マクロファージを用いた破骨細胞形成能と骨吸収活性の解析2011
- Author(s)
  水谷大樹, 石原裕一, 藤原祐子, 伊澤有郎, 小澤佑介, 神谷洋介, 近藤久貴, 西原達次, 戸刈彰史, 野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-32 IN GINGIVAL CREVICULAR FLUIDS AND GINGIVAL TISSUE FROM PERIODONTITIS PATIENTS2010
- Author(s)
  Y.Ishihara
- Organizer
  第96回アメリカ歯周病学会
- Place of Presentation
  ハワイコンベンションセンター(ハワイ)
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] ラット実験的歯周炎における破骨細胞形成とIL-1ファミリーの動態2010
- Author(s)
  小澤佑介, 石原裕一, 水谷大樹, 伊澤有郎, 亀井英彦, 田中繁寿, 林潤一郎、三谷章雄, 神谷洋介, 西原達次, 前田初彦, 野口俊英
- Organizer
  第53回秋季日本歯周病学会
- Place of Presentation
  高松
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] Metagenomic analysis of the dental plaque2010
- Author(s)
  Hayashi J, Kondo S, Morita H, Kamei H, Fukuda M, Ishihara Y, Kojima T, Noguchi T
- Organizer
  96^<th> American Academy of Periodotology Annual Meeting
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-20249082
[Presentation] IL-1RaKOマウス腹腔マクロファージからのIL-1産生亢進2010
- Author(s)
  水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野誠、神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 西原達次, 前田初彦, 野口俊英
- Organizer
  第53回秋季日本歯周病学会
- Place of Presentation
  高松
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cell2009
- Author(s)
  Y. Ishihara, Y. Kamiya, Y. Ozawa, A. Nagahara, H. Mizutani, S. Tanaka, H. Kamei, T. Noguchi
- Organizer
  The 95th annual meeting of the American Academy of Periodontology
- Place of Presentation
  Boston, USA
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] 歯周病におけるIL-1の働き2009
- Author(s)
  石原裕一
- Organizer
  再生補綴医学研究会・第2回学術会議
- Place of Presentation
  名古屋
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cells2009
- Author(s)
  石原裕一
- Organizer
  The 95^<th> annual meeting of the American Academy of Periodontology
- Place of Presentation
  Boston, USA
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] 歯周病におけるIL-1レセプターtypeIIの働きについて2008
- Author(s)
  石原裕一, 11名
- Organizer
  第21回日本歯科医学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19592397
[Presentation] Osteoclast differentiation and function is inhibited by Ca^<2+> channel blocker, diphenylhydantoin(DPH).2007
- Author(s)
  Ishihara Y
- Organizer
  The 93nd annual meeting of the American Academy of Periodontology
- Place of Presentation
  Washington, D. C. USA
- Data Source
  KAKENHI-PROJECT-19592397
[Presentation] IL-1RaKOマウスにおける骨代謝の低下
- Author(s)
  伊澤有郎，石原裕一，水谷大樹，小林周一郎，小澤佑介，神谷洋介，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第80回愛知学院大学歯学会学術大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] Serum sIL-1RAcP levels are correlated with periodontal disease severity
- Author(s)
  Y Ishihara, H Mizutani, A Izawa, E Okabe, H Goto, Y Ozawa, M Aino, H Kamei, A Mitani, J Hayashi, K Inagaki, M Fukuda, T Noguchi
- Organizer
  98TH Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第56回秋季日本歯周病学会
- Place of Presentation
  前橋（群馬）
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] 歯周炎患者における末梢血血清中のsIL-1RAcPと臨床所見との関係
- Author(s)
  水谷大樹，石原裕一，伊澤有郎，小澤佑介，相野　誠，亀井英彦，三谷章雄，林潤一郎，稲垣幸司，福田光男，野口俊英
- Organizer
  第55回春季日本歯周病学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] The Effect of Interleukin-15 on Inflammatory Bone Metabolism
- Author(s)
  Akio MITANI, Hiroaki TAKEDA, Takeshi KIKUCHI, Kyoko SOBOKU, Sachiko FUJITA, Yuichi ISHIHARA, Toshihide NOGUCHI
- Organizer
  EUROPEAN CONGRESS OF IMMUNOLOGY
- Place of Presentation
  Glasgow, Scotland, UK
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] 末梢血血清中の可溶性インターロイキン－１補助タンパクの歯周病マーカーとしての可能性
- Author(s)
  小澤佑介，石原裕一，亀井英彦，水谷大樹，伊澤有郎，岡部栄治郎，後藤久嗣，久野　茜，須川雄司，猪子将成，神谷洋介，野口俊英
- Organizer
  第8回日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
- Place of Presentation
  松本（長野）
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] Characteristics of Epithelial cell attachment to zirconia similar to titanium
- Author(s)
  Ishihara Y, Okabe E, Sasaki K, Kobayashi S, Mizutani H, Izawa A, Goto H, Murakami H, Ban S, Kawai T, Noguchi T
- Organizer
  the 2nd Meeting of the International Association for Dental Research Asia Pacific Region
- Place of Presentation
  Bangkok
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] A.actinomycetemcomitans菌刺激したIL-1Ra欠損マウス由来骨芽細胞の造骨系骨関連遺伝子発現
- Author(s)
  伊澤有郎，石原裕一，水谷大樹，小林周一郎，小澤佑介，神谷洋介，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第55回春季日本歯周病学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] IL-15 の炎症性骨代謝に対する影響
- Author(s)
  武田紘明, 菊池毅, 惣ト響子, 相野誠, 三谷章雄, 石原裕一, 野口俊英
- Organizer
  第 55 回春季日本歯周病学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] 歯周炎患者における末梢血血清中の sIL-1RAcP と臨床所見の関係
- Author(s)
  水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野誠, 亀井英彦, 三谷章雄, 林潤一郎, 稲垣幸司, 福田光男, 野口俊英
- Organizer
  第 55 回春季日本歯周病学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] 骨縁下欠損に対するエナメルマトリックスタンパク質を応用した歯周組織再生療法５年経過症例の臨床的検討
- Author(s)
  三谷章雄，高須英成，吉成伸夫，伊藤正満，川瀬仁史，相野誠，林潤一郎，稲垣幸司，黒須康成，三輪晃資，石原裕一，福田光男，野口俊英
- Organizer
  第136回日本歯科保存学会春季学術大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24593134

1. YOSHINARI Nobuo (20231699)

# of Collaborated Projects: 9 results

# of Collaborated Products: 6 results
2. MITANI Akio (50329611)

# of Collaborated Projects: 7 results

# of Collaborated Products: 30 results
3. KOIDE Masanori (10367617)

# of Collaborated Projects: 7 results

# of Collaborated Products: 8 results
4. NOGUCHI Toshihide (50014262)

# of Collaborated Projects: 6 results

# of Collaborated Products: 26 results
5. KAMEI Hidehiko (50421243)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
6. TAGUCHI Akira (70243582)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. 宇田川信之 (70245801)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
8. TANAKA Shigehisa (30367619)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
9. OHGUCHI Masahiro (00319196)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 尾崎友輝 (10802902)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 松下健二 (90253898)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
12. HAYASHI Junichiro (30350937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. MORITA Hidetoshi (70257294)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
14. HATTORI Masahira (70175537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. UEDA Nobuo (30291769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 佐治直樹 (30624910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
17. KOJIMA Toshio (00311340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. FUKUDA Mitsuo (40156790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. TOH Hidehiro (10353468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. KIKUCHI Takeshi (40421242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
21. AINO Makoto (20572811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. FUJIMURA Takeki (40749892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. MORITA Hidetoshi (70957294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. OZAWA Yusuke (50624326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
25. YOSHIE Hiromasa (20143787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Yoshida Yasuo (10315096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. INAGAKI Koji (50211058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. MIKI Takami (90174002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. Ohta Kouichi (70262730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 高柴正悟 (50226768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 永田俊彦 (10127847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 小林哲夫 (00215344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 木戸淳一 (10195315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 大森一弘 (20549860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 前田博史 (00274001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
36. 吉村文信 (50001962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 毛塚雄一郎 (50397163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 天埜克彦 (90231117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 森田一三 (50301635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 川瀬仁史 (60329612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
41. 祖父江尊範 (90319195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 平賀徹 (70322170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 上原俊介 (90434480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
44. 中本哲自 (30514989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 里直行 (70372612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 多田浩之 (70431632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
47. 山田匡恵 (90439456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 嶋崎義浩 (10291519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. 鈴木万里代

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 神谷洋介

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. 小林泰浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIHARA Yuichi 石原 裕一

Research Projects

Research Products

Co-Researchers

The practice of ICT-applied Kami kami Goku Goku Exercise contributes to the maintenance and improvement of oral functions of the elderlyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高齢者認知機能低下に係る歯周病病態、口腔細菌および口腔機能の影響についての研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a potential new marker of periodontal disease status based on serum IL-1 receptor accessory protein .Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clofibrate produce IL-1Ra and inhibit the experimental periodontitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of IL-1Ra in periodontal tissue destruction with IL-1Ra-deficient micePrincipal Investigator

Principal Investigator

ISHIHARA Yuichi 石原裕一