ISHIHARA Yuichi 石原裕一

Researcher Number	50261011
Other IDs
External Links
Affiliation (Current)	2020: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長
Affiliation (based on the past Project Information) *help	2019: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長 2013 – 2018: 松本歯科大学, 歯学部, 教授 2007 – 2013: Aichi Gakuin University, 歯学部, 准教授 2000 – 2006: 愛知学院大学, 歯学部, 講師 1994 – 1999: 愛知学院大学, 歯学部, 助手 1998: 助手
Review Section/Research Field	Principal Investigator Conservative dentistry / Periodontal dentistry / Periodontal dentistry / 病態科学系歯学(含放射線系歯学) / Periodontology / Basic Section 57030:Conservative dentistry-related Except Principal Investigator Periodontal dentistry / Basic Section 57030:Conservative dentistry-related / Periodontology / Morphological basic dentistry / Conservative dentistry / Periodontal dentistry / Ophthalmology
Keywords	Principal Investigator 歯肉溝滲出液 / IL-1 / インターロイキン-1 / 破骨細胞 / TIMP / 実験的歯周炎 / LPS / Actinobacillus actinomycetemcomitans / インターロイキン-1レセプターアンタゴニスト / インターロイキン1 … More Except Principal Investigator 歯周病 / 歯周炎 / 破骨細胞 / 歯学 / Actinobacillus actinomycetemcomitans / 骨吸収 / interleukin-1 / periodontal disease / IL-15 / Th1 / OIP-1 / IFN-γ / メタゲノム解析 / 口腔細菌叢 / 歯周病関連細菌 / ゲノムDNA抽出 / 歯肉縁上プラーク / 歯肉縁下プラーク / 16SrRNA遺伝子解析 / IL-35 / 歯周組織 / Th17 / 免疫学 / IL-17 / プラーク細菌叢 / 臨床株 / 16SrRNA解析 / ゲノム解析 / う蝕細菌 / プラーク細菌 / サイトカイン遺伝子 / 糖尿病 / 関節リウマチ / 短鎖脂肪酸 / Porphyromonas gingivalis / 酪酸 / 代謝 / 歯周疾患 / 莢膜多糖 / プロスタグランディン / インターロイキン1 / インターロイキン1レセプターアンタゴニスト / 若年性歯周炎 / Actinobocillus actinomycetemcomitans / capsular polysaccharide / bone nesorption / prostagrandin / 粘膜感染 / γδT細胞 / 上皮系サイトカイン / Mucosal infection / γδT cell / IL-1β / Periodontitis / Bone resorption / Osteoclast / 骨粗鬆症 / 骨密度 / 地域歯周疾患指数 / フラクタル次元 / ビスフォスフォネート / osteoporosis / bone mineral density / community periodontal index / fractal dimension / bisphosphonate / 実験的歯周炎 / 拘束ストレス / マイクロアレイ / 遺伝子発現 / experimental periodontitis / restraint stress / microarray / gene expression / 加齢黄斑変性 / 動脈硬化 / 外科 / 眼科 / スクレロスチン / 骨代謝 / 歯周治療 / 老化制御 / 動脈硬化症 / 分子基盤 Less

血清中IL-1受容体補助タンパク濃度を用いた新規歯周病病態マーカーの開発Principal InvestigatorOngoing
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  The Lion Foundation for Dental Health
破骨細胞によるスクレロスチン分泌制御を基盤とした新規歯周治療薬の開発Ongoing
- Principal Investigator
  
  小出雅則
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Matsumoto Dental University
Elucidation of molecular basis for the relationship between periodontal disease and atherosclerosis by controlling agingOngoing
- Principal Investigator
  
  吉成伸夫
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Matsumoto Dental University
Association subtype of age-relrated macular degeneration and periodontal diseaseOngoing
- Principal Investigator
  
  太田浩一
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Matsumoto Dental University
Clofibrate produce IL-1Ra and inhibit the experimental periodontitisPrincipal Investigator
- Principal Investigator
  
  Ishihara Yuichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Matsumoto Dental University
Elucidation and control of effect of short chain fatty acids on periodontopathogens
- Principal Investigator
  
  Yoshida Yasuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Aichi Gakuin University
An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
The role of IL-35 on Th17 cells in inflamed gingiva
- Principal Investigator
  
  MITANI Akio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Genome sequencing of clinical strains isolated from dental plaque for investigation of polymicrobial factors in periodontal pathogenesis
- Principal Investigator
  
  HAYASHI Jun-ichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Effect of IL-1Ra in periodontal tissue destruction with IL-1Ra-deficient micePrincipal Investigator
- Principal Investigator
  
  ISHIHARA YUICHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Matsumoto Dental University
  Aichi Gakuin University
Effect of the IL-1 typeIIreceptor to a experimental periodontitis infected with periodontal bacteriumPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Metagenomic Analysis of Oral Microbiota from Normal Subjects and Patients with Periodontal Disease
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
A function of soluble Interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
Efficacy of therapy for osteoporosis on oral health
- Principal Investigator
  
  INAGAKI Koji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin Unviersity
The roll of soluble interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin university
Effect of restraint stress on the gene expression in periodontal tissue of rat experimental periodontitis
- Principal Investigator
  
  YOSHINARI Nobuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin University
The working mechanism of bone resorption inhibitory protein induced by osteoclasts
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin University
The effects of the role of cytokine stimulated capsular polysaccharide Actinobacillus actinomycetemcomitans in human gingival fibroblast and monocyte.Principal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Aichi-Gakuin University
The investigation of the role of cytokine from derived epithelial cell for activation γδ T cells in mucosal infection
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-Gakuin University
The specificity of cytokine production from inflammatory gingivaPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi Gakuin University
The effect of TIMP on bone resorption and osteoclast like cell formation induced by juvenile periodontitis related bacteriaPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Yuichi, 上田信男
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Aichi-gakuin University
歯周炎患者における歯周組織中のIL-1の相互作用についてPrincipal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University
マウス骨髄細胞培養系による破骨細胞形成に対するTIMPの役割についてPrincipal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University
Cell-surface components Actinobacillus actinomycetemcomitans promote osteoclast formation in vitro
- Principal Investigator
  
  NOGUCHI Toshihide
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi-gakuin University
歯周炎患者の歯肉溝滲出液中のIL-1とIL-1raの動態に関する研究Principal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University
歯周炎患者の歯肉溝滲出液中のIL-1とIL-1raの動態に関する研究Principal Investigator
- Principal Investigator
  
  石原裕一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University

All 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study2018
- Author(s)
  Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
- Journal Title
  
  Journal of Periodontology
  
  Volume: 89(3) Pages: 315-324
- DOI
  10.1002/jper.17-0412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K11983, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15764
[Journal Article] Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice.2017
- Author(s)
  Ishida N, Ishihara Y, Ishida K, Tada H, Funaki-Kato Y, Hagiwara M, Ferdous T, Abdullah M, Mitani A, Michikawa M, Matsushita K.
- Journal Title
  
  NPJ Aging Mech Dis.
  
  Volume: 3 Pages: 15-15
- DOI
  10.1038/s41514-017-0015-x
- NAID
  120006576159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11824, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K17362, KAKENHI-PROJECT-26293438, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15712, KAKENHI-PROJECT-26861586, KAKENHI-PROJECT-16H05559
[Journal Article] Adhesion properties of human oral epithelial-derived cells to zirconia.2016
- Author(s)
  Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Sasaki K, Ban S, Noguchi T, Kawai T, Mitani A.
- Journal Title
  
  Clin Implant Dent Relat Res
  
  Volume: 10 Pages: 906-916
- DOI
  10.1111/cid.12369
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-26463149
[Journal Article] Interleukin-1 receptor antagonist has a novel function in the regulation of matrix metalloproteinase-13 expression2015
- Author(s)
  Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0140942
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-26463149, KAKENHI-PROJECT-25253104
[Journal Article] Increased Expression of Interleukin-35 and -17, but not -27, in Gingival Tissues with Chronic Periodontitis.2015
- Author(s)
  Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T.
- Journal Title
  
  J Periodontol
  
  Volume: 86 Pages: 301-309
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis2015
- Author(s)
  Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T
- Journal Title
  
  J Periodontol
  
  Volume: 86 Pages: 301-309
- DOI
  10.1902/jop.2014.140293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134
[Journal Article] Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture.2014
- Author(s)
  Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T
- Journal Title
  
  Inflammation
  
  Volume: 37 Pages: 657-669
- DOI
  10.1007/s10753-013-9782-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-26463149
[Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
- Journal Title
  
  Modern Research in Inflammation
  
  Volume: 3 Pages: 37-47
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24593137
[Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells.2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
- Journal Title
  
  Modern Research in Inflammation
  
  Volume: 3 Pages: 37-47
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] IL-1ファミリーとIL-1受容体：歯周病疾患マーカーや治療薬としての可能性2014
- Author(s)
  石原裕一，亀井英彦，神谷洋介，伊澤有郎，水谷大樹，鈴木万里代，野口俊英，三谷章雄
- Journal Title
  
  日歯周誌
  
  Volume: 56 Pages: 272-280
- NAID
  130004842577
- Data Source
  KAKENHI-PROJECT-24593137
[Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in Japanese.2014
- Author(s)
  Kamei H, Ishihara Y, Fuma D, Niwa T, Kamiya Y, Yokoi T, Suzuki M, Izawa A, Mizutani H, Hayashi J, Sakaki Y, Noguchi T, Kojima T.
- Journal Title
  
  Arch. Oral Biol.
  
  Volume: 59 Pages: 756-763
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Inflammatory Bone Loss in Experimental Periodontitis Induced by Aggregatibacter actinomycetemcomitans in Interleukin-1 Receptor Antagonist Knockout Mice.2014
- Author(s)
  Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J, Nishihara T, Maeda H, Noguchi T
- Journal Title
  
  Infection and Immunity
  
  Volume: 82 Pages: 1904-1913
- DOI
  10.1128/iai.01618-13
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463149
[Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in Japanese.2014
- Author(s)
  Kamei H、Ishihara Y, 12 others
- Journal Title
  
  Archives of Oral Biology
  
  Volume: Vol. 59、No. 7 Pages: 756-763
- DOI
  10.1016/j.archoralbio.2014.04.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23593079, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-25870860
[Journal Article] IL-1 Receptor Type II Production Is Upregulated by IL-4 and IL-13, and Downregulated by IFN-γ in Mouse Gingival Epithelial Cells2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T
- Journal Title
  
  Modern Research in Inflammation
  
  Volume: 3 Pages: 37-47
- DOI
  10.4236/mri.2014.32005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593137
[Journal Article] TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1.2014
- Author(s)
  Kato Y, Hagiwara M, Ishihara Y, Isoda R, Sugiura S, Komatsu T, Ishida N, Noguchi T, Matsushita K.
- Journal Title
  
  BMC Microbiology
  
  Volume: 14 Pages: 229-229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture.2014
- Author(s)
  Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
- Journal Title
  
  Inflammation
  
  Volume: 37 Pages: 657-669
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104
[Journal Article] Effect of IL-15 and natural killer cells on osteoclast and osteoblast in a mouse coculture2013
- Author(s)
  Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
- Journal Title
  
  Inflammation
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593134
[Journal Article] Lipopolysaccharide of Aggregati- bacter actinomycetemcomitans upregulates inflammatory cytokines, PGE2 synthesis, and osteoclast formation in IL-1Ra deficient mice.2013
- Author(s)
  Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T.
- Journal Title
  
  J Periodont Res
  
  Volume: 48 Pages: 748-756
- DOI
  10.1111/jre.12065
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-25253104
[Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates T cell activation2013
- Author(s)
  Suga T, Mitani A, Mogi M, Kikuchi T, Fujimura T, Takeda H, Hishikawa T, Yamamoto G, Hayashi J, Ishihara Y, Noguchi T.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 58 Pages: 1541-1548
- DOI
  10.1016/j.archoralbio.2013.06.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593134
[Journal Article] Valproic Acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 12011
- Author(s)
  Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
- Journal Title
  
  Shock
  
  Volume: 36 Pages: 494-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592638
[Journal Article] Degradation of vascular endothelial thrombomodulin by arginine-and lysin-specific cysteine proteases from Porphyromonas gingivalis2009
- Author(s)
  Inomata M, Ishihara Y, Matsuyama T, Murayama I, Noguchi T, Matsushita K
- Journal Title
  
  J.Periodontol. 80
  
  Pages: 1511-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249082
[Journal Article] Degradation of vascular endothelial thrombomodulin by arginine-and lysin-specific cysteine proteases from Porphyromonas gingivalis.2009
- Author(s)
  Inomata M, Ishihara Y, Matsuyama T, Murayama I, Noguchi T, Matsushita K.
- Journal Title
  
  J.Periodontol. 8
  
  Pages: 1511-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249082
[Journal Article] Soluble Interleukin-1 Receptor Type II Levels in Gingival Crevicular Fluid in Aggressive and Chronic Periodontitis2008
- Author(s)
  Suzuki M, Ishihara.Y, Kamei H, 10名
- Journal Title
  
  J Periodontol 79巻
  
  Pages: 495-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592397
[Journal Article] Actinobacillus actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells.2005
- Author(s)
  Iwata T, Mitani A, Ishihara Y et al.
- Journal Title
  
  Clin Exp Immuno 141
  
  Pages: 261-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] A.actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells2005
- Author(s)
  Iwata T, Mitani A, Ishihara Y, Koide M, Sobue T, Noguchi T
- Journal Title
  
  Clin Exp Immuno 141
  
  Pages: 261-269
- Data Source
  KAKENHI-PROJECT-15390648
[Journal Article] Actinobacillus actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells2005
- Author(s)
  Iwata T, Mitani A, Ishihara Y et al.
- Journal Title
  
  Clin Exp Immuno 141
  
  Pages: 261-269
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] TIMP-1およびTIMP-2は破骨細胞形成を促進する2005
- Author(s)
  祖父江尊範, 小出雅則, 石原裕一, 野口俊英
- Journal Title
  
  日本歯周病学会誌 47(4)
  
  Pages: 297-308
- NAID
  10016919077
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390648
[Journal Article] 閉経が歯肉溝滲出液中のインターロイキン-1濃度に及ぼす影響2004
- Author(s)
  夫馬大介, 稲垣幸司, 石原祐一他
- Journal Title
  
  日歯周誌 46・4
  
  Pages: 259-265
- NAID
  10014078774
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] 閉経が歯肉溝滲出液中のインターロイキン・1濃度に及ぼす影響2004
- Author(s)
  夫馬大介, 稲垣幸司, 石原裕一他
- Journal Title
  
  日歯周誌 46・4
  
  Pages: 259-265
- NAID
  10014078774
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effect of Menopause on Interleukin-1 Concentration in Gingival Crevicular Fluids2004
- Author(s)
  Fuma D, Inagaki K, Ishihara Y et al.
- Journal Title
  
  J Jpn Soc Periodontol 46
  
  Pages: 259-265
- NAID
  10014078774
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6Zr alloy against MG63 osteoblast like cell.2004
- Author(s)
  Naganawa T, Ishihara Y, Iwata T. et al.
- Journal Title
  
  J Periodontol 75・12
  
  Pages: 1701-1707
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Delineation of the Role of Platelet-Activating Factor in the Immunoglobulin G2 Antibody Response.2004
- Author(s)
  Al-Darmaki S, Knightshead K, Ishihara Y et al.
- Journal Title
  
  Clin Diagn Lab Immunol 11
  
  Pages: 720-728
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6 Zr alloy against MG63 osteoblast like cell.2004
- Author(s)
  Naganawa T, Ishihara Y, Iwata T. et al.
- Journal Title
  
  J Periodontol 75・12
  
  Pages: 1701-1707
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6Zr alloy against MG63 osteoblast like cell.2004
- Author(s)
  Naganawa T, Ishihara Y, Iwata T. et al.
- Journal Title
  
  J Periodontol 75
  
  Pages: 1701-1707
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues.2004
- Author(s)
  Yoshinari N, Kawase H, Mitani M, Shirozu N, Ishihara Y et al.
- Journal Title
  
  J Periodontal Res 39・3
  
  Pages: 158-167
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response.2004
- Author(s)
  Al-Darmaki S, Knightshead K, Ishihara Y, et al.
- Journal Title
  
  Clin Diagn Lab Immunol 11
  
  Pages: 720-728
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1β in gingival crevicular fluid and gingival tissues.2004
- Author(s)
  Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T.
- Journal Title
  
  Journal of Periodontal Research 39
  
  Pages: 158-167
- Data Source
  KAKENHI-PROJECT-16592083
[Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1 beta in gingival crevicular fluid and gingival tissue.2004
- Author(s)
  Yoshinari N, Kawase H, Mitani M, Shirozu N., Ishihara
- Journal Title
  
  J Periodontal Res 39・3
  
  Pages: 158-167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592082
[Journal Article] Capsular polysaccharide from Actiaobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast.2003
- Author(s)
  Ohguchi Y, Ishihara Y, Koide M, Noguchi T. et al.
- Journal Title
  
  J Periodont Res 38(2)
  
  Pages: 191-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390648
[Journal Article] Capsular polysaccharide from Actinobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast.2003
- Author(s)
  Ohguchi Y, Ishihara Y, Koide M, Noguchi T.
- Journal Title
  
  J Periodont Res 38(2)
  
  Pages: 191-197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390648
[Presentation] 破骨細胞由来のLIFは,sclerostin発現を低下させて骨形成を促進する2018
- Author(s)
  小出雅則, 尾崎友輝, 中村圭吾, 宇田川信之, 石原裕一, 吉成伸夫
- Organizer
  日本歯周病学会会誌(Web)
- Data Source
  KAKENHI-PROJECT-18H02980
[Presentation] IL-1Ra欠損マウスでの破骨細胞形成と炎症性骨吸収が亢進する2017
- Author(s)
  石原裕一，小出雅則，吉成伸夫
- Organizer
  第2回日本骨免疫学会ウインターセミナ
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] IL-1Ra欠損マウスでは破骨細胞形成と炎症性骨吸収が亢進する2017
- Author(s)
  石原裕一，小出雅則，吉成伸夫
- Organizer
  第２回日本骨免疫学会ウインターセミナー
- Place of Presentation
  ホテルマロウド軽井沢（長野）
- Year and Date
  2017-01-27
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] 歯周組織におけるIL-1Raの役割と治療薬への可能性2017
- Author(s)
  石原裕一
- Organizer
  60回春季日本歯周病学会学術大会学会学術賞記念講演
- Invited
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] The Effect of Serum Amyloid A for Endothelial Cell2016
- Author(s)
  Yoshinari,N., Takahashi K., Kaise K., Saleem M., Ozaki Y., Nakamura S., Kubokawa K., Ishihara Y.
- Organizer
  94th General session of the IADR
- Place of Presentation
  Seoul　(Korea)
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] 骨吸収はsclerostinの発現低下を介して骨形成を促進する2016
- Author(s)
  小出雅則、尾崎友輝、吉成伸夫、石原裕一、宇田川信之
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  鹿児島県民交流センター(鹿児島)
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] ジルコニアに対するヒト口腔由来上皮細胞の付着特性2015
- Author(s)
  郎，石原裕一，菊池　毅，伊澤有郎，小林周一郎，後藤久嗣，神谷洋介，伴　清治，野口俊英，河合逹志，三谷章雄
- Organizer
  第58回秋季日本歯周病学会学術大会
- Place of Presentation
  浜松アクトシティ浜松
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] Adhesion properties of human oral epithelial-derived cells to zirconia2015
- Author(s)
  Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Ban S, Noguchi T, Kawai T and Mitani A
- Organizer
  第63回国際歯科研究会日本部会総会・学術総会
- Place of Presentation
  福岡　福岡国際会議場
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-15K11402
[Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients2014
- Author(s)
  Yosuke Kamiya, Yuichi Ishihara, Hidehiko Kamei, Ario Izawa, Eijiro Okabe, Hisashi Goto, Akane Kuno, Yuji Sugawa, Yusuke Ozawa, Akio Mitani
- Organizer
  2014 Annual Meeting of American Academy of Periodontology
- Place of Presentation
  San Francisco
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] Interleukin-1 receptor antagonistは歯肉上皮細胞からのMatrix metalo- peptidase 13発現を抑制する2014
- Author(s)
  後藤久嗣,　石原裕一,　伊澤有郎,　岡部栄治郎,　久保勝俊,　杉田好彦,　前田初彦,　野口俊英, 三谷章雄
- Organizer
  第57回秋季日本歯周病学会
- Place of Presentation
  神戸
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する2014
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英，三谷章雄
- Organizer
  第57回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する.2014
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英，三谷章雄
- Organizer
  秋季日本歯周病学会学術大会
- Place of Presentation
  神戸国際展示場(兵庫)
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
- Organizer
  2014 Annual Meeting of American Academy of Periodontology
- Place of Presentation
  Moscone center, San Francisco, USA
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014
- Author(s)
  Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
- Organizer
  the 100th Annual Meeting of American Academy of Periodontology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] インターロイキン１レセプターアンタゴニストのコラゲナーゼ３(MMP-13)発現抑制について2014
- Author(s)
  後藤久嗣、石原裕一、伊澤有郎、岡部栄次郎、久保勝俊、杉田好彦、前田初彦、野口俊英、三谷章雄
- Organizer
  第85回愛知学院大学歯学会
- Place of Presentation
  愛知学院大学楠元キャンパス(愛知)
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] 垂直性骨欠損に対し GTR 法とエナメルマトリックスタンパク質を用いた歯周組織再生療法を行った症例の 5 年経過時における臨床的比較2013
- Author(s)
  相野誠, 三谷章雄, 高須英成, 古田英豊, 永坂太郎, 三輪晃資, 菊池毅, 川瀬仁史, 伊藤正満, 林潤一郎, 黒須康成,石原裕一, 稲垣幸司, 福田光男, 野口俊英.
- Organizer
  日本歯科保存学会春期学術大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響2013
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第56回秋季日本歯周病学会
- Place of Presentation
  前橋市市民文化会館（前橋市）
- Year and Date
  2013-09-22
- Data Source
  KAKENHI-PROJECT-25253104
[Presentation] IL-1Ra欠損マウスの破骨細胞形成能と実験的歯周炎について2011
- Author(s)
  石原裕一, 水谷大樹, 伊澤有郎, 三谷章雄, 黒須康成, 川瀬仁史, 稲垣幸司, 野口俊英
- Organizer
  第135回日本歯科保存学会秋季学術大会
- Place of Presentation
  大阪
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] ヒト歯周病細菌叢のメタゲノム解析2011
- Author(s)
  林潤一郎,近藤伸二、亀井英彦、森田英利、足立直樹、福田光男、Todd D Taylor、石原裕一、小島俊男、野口俊英
- Organizer
  第5回日本ゲノム微生物学会
- Place of Presentation
  仙台
- Year and Date
  2011-03-14
- Data Source
  KAKENHI-PROJECT-20249082
[Presentation] 歯周病関連細菌Porphyromonas gingivalisの歯肉上皮細胞への侵入機構の解明2011
- Author(s)
  加藤佳子, 杉浦進介, 小松寿明, 石原裕一, 野口俊英, 松下健二
- Organizer
  第54回春季日本歯周病学会
- Place of Presentation
  福岡
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウス腹腔マクロファージにおける骨吸収活性の解析2011
- Author(s)
  水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 久保勝俊, 西原達次, 前田初彦, 野口俊英
- Organizer
  第3回口腔先端応用医科学研究会
- Place of Presentation
  東京
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1RaKOマウス腹腔マクロファージを用いた破骨細胞形成能と骨吸収活性の解析2011
- Author(s)
  水谷大樹, 石原裕一, 藤原祐子, 伊澤有郎, 小澤佑介, 神谷洋介, 近藤久貴, 西原達次, 戸刈彰史, 野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウスを用いたA.actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現2011
- Author(s)
  伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1Ra欠損マウスを用いたA. actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現2011
- Author(s)
  伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] プラーク細菌叢のメタゲノム解析2011
- Author(s)
  林潤一郎、亀井英彦、福田光男、石原裕一、野口俊英
- Organizer
  第54回秋季日本歯周病学会
- Place of Presentation
  下関
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] IL-1RaKOマウス腹腔マクロファージからのIL-1産生亢進2010
- Author(s)
  水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野誠、神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 西原達次, 前田初彦, 野口俊英
- Organizer
  第53回秋季日本歯周病学会
- Place of Presentation
  高松
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] Metagenomic analysis of the dental plaque2010
- Author(s)
  Hayashi J, Kondo S, Morita H, Kamei H, Fukuda M, Ishihara Y, Kojima T, Noguchi T
- Organizer
  96^<th> American Academy of Periodotology Annual Meeting
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-20249082
[Presentation] IL-32 IN GINGIVAL CREVICULAR FLUIDS AND GINGIVAL TISSUE FROM PERIODONTITIS PATIENTS2010
- Author(s)
  Y.Ishihara
- Organizer
  第96回アメリカ歯周病学会
- Place of Presentation
  ハワイコンベンションセンター(ハワイ)
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] ラット実験的歯周炎における破骨細胞形成とIL-1ファミリーの動態2010
- Author(s)
  小澤佑介, 石原裕一, 水谷大樹, 伊澤有郎, 亀井英彦, 田中繁寿, 林潤一郎、三谷章雄, 神谷洋介, 西原達次, 前田初彦, 野口俊英
- Organizer
  第53回秋季日本歯周病学会
- Place of Presentation
  高松
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] 歯周病におけるIL-1の働き2009
- Author(s)
  石原裕一
- Organizer
  再生補綴医学研究会・第2回学術会議
- Place of Presentation
  名古屋
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cells2009
- Author(s)
  石原裕一
- Organizer
  The 95^<th> annual meeting of the American Academy of Periodontology
- Place of Presentation
  Boston, USA
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cell2009
- Author(s)
  Y. Ishihara, Y. Kamiya, Y. Ozawa, A. Nagahara, H. Mizutani, S. Tanaka, H. Kamei, T. Noguchi
- Organizer
  The 95th annual meeting of the American Academy of Periodontology
- Place of Presentation
  Boston, USA
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21592638
[Presentation] 歯周病におけるIL-1レセプターtypeIIの働きについて2008
- Author(s)
  石原裕一, 11名
- Organizer
  第21回日本歯科医学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19592397
[Presentation] Osteoclast differentiation and function is inhibited by Ca^<2+> channel blocker, diphenylhydantoin(DPH).2007
- Author(s)
  Ishihara Y
- Organizer
  The 93nd annual meeting of the American Academy of Periodontology
- Place of Presentation
  Washington, D. C. USA
- Data Source
  KAKENHI-PROJECT-19592397
[Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響
- Author(s)
  後藤久嗣，石原裕一，伊澤有郎，岡部栄治郎，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第56回秋季日本歯周病学会
- Place of Presentation
  前橋（群馬）
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] 歯周炎患者における末梢血血清中のsIL-1RAcPと臨床所見との関係
- Author(s)
  水谷大樹，石原裕一，伊澤有郎，小澤佑介，相野　誠，亀井英彦，三谷章雄，林潤一郎，稲垣幸司，福田光男，野口俊英
- Organizer
  第55回春季日本歯周病学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] 歯周炎患者における末梢血血清中の sIL-1RAcP と臨床所見の関係
- Author(s)
  水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野誠, 亀井英彦, 三谷章雄, 林潤一郎, 稲垣幸司, 福田光男, 野口俊英
- Organizer
  第 55 回春季日本歯周病学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] 末梢血血清中の可溶性インターロイキン－１補助タンパクの歯周病マーカーとしての可能性
- Author(s)
  小澤佑介，石原裕一，亀井英彦，水谷大樹，伊澤有郎，岡部栄治郎，後藤久嗣，久野　茜，須川雄司，猪子将成，神谷洋介，野口俊英
- Organizer
  第8回日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
- Place of Presentation
  松本（長野）
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] A.actinomycetemcomitans菌刺激したIL-1Ra欠損マウス由来骨芽細胞の造骨系骨関連遺伝子発現
- Author(s)
  伊澤有郎，石原裕一，水谷大樹，小林周一郎，小澤佑介，神谷洋介，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第55回春季日本歯周病学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] 骨縁下欠損に対するエナメルマトリックスタンパク質を応用した歯周組織再生療法５年経過症例の臨床的検討
- Author(s)
  三谷章雄，高須英成，吉成伸夫，伊藤正満，川瀬仁史，相野誠，林潤一郎，稲垣幸司，黒須康成，三輪晃資，石原裕一，福田光男，野口俊英
- Organizer
  第136回日本歯科保存学会春季学術大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] The Effect of Interleukin-15 on Inflammatory Bone Metabolism
- Author(s)
  Akio MITANI, Hiroaki TAKEDA, Takeshi KIKUCHI, Kyoko SOBOKU, Sachiko FUJITA, Yuichi ISHIHARA, Toshihide NOGUCHI
- Organizer
  EUROPEAN CONGRESS OF IMMUNOLOGY
- Place of Presentation
  Glasgow, Scotland, UK
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] IL-1RaKOマウスにおける骨代謝の低下
- Author(s)
  伊澤有郎，石原裕一，水谷大樹，小林周一郎，小澤佑介，神谷洋介，久保勝俊，杉田好彦，前田初彦，野口俊英
- Organizer
  第80回愛知学院大学歯学会学術大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] IL-15 の炎症性骨代謝に対する影響
- Author(s)
  武田紘明, 菊池毅, 惣ト響子, 相野誠, 三谷章雄, 石原裕一, 野口俊英
- Organizer
  第 55 回春季日本歯周病学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24593134
[Presentation] Characteristics of Epithelial cell attachment to zirconia similar to titanium
- Author(s)
  Ishihara Y, Okabe E, Sasaki K, Kobayashi S, Mizutani H, Izawa A, Goto H, Murakami H, Ban S, Kawai T, Noguchi T
- Organizer
  the 2nd Meeting of the International Association for Dental Research Asia Pacific Region
- Place of Presentation
  Bangkok
- Data Source
  KAKENHI-PROJECT-24593137
[Presentation] Serum sIL-1RAcP levels are correlated with periodontal disease severity
- Author(s)
  Y Ishihara, H Mizutani, A Izawa, E Okabe, H Goto, Y Ozawa, M Aino, H Kamei, A Mitani, J Hayashi, K Inagaki, M Fukuda, T Noguchi
- Organizer
  98TH Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-24593134

1. MITANI Akio (50329611)

# of Collaborated Projects: 7 results

# of Collaborated Products: 33 results
2. NOGUCHI Toshihide (50014262)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
3. KOIDE Masanori (10367617)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
4. YOSHINARI Nobuo (20231699)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
5. KAMEI Hidehiko (50421243)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
6. TANAKA Shigehisa (30367619)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. OHGUCHI Masahiro (00319196)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. TAGUCHI Akira (70243582)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. HAYASHI Junichiro (30350937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. HATTORI Masahira (70175537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. UEDA Nobuo (30291769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 宇田川信之 (70245801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. KOJIMA Toshio (00311340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. MORITA Hidetoshi (70257294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. FUKUDA Mitsuo (40156790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. TOH Hidehiro (10353468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. KIKUCHI Takeshi (40421242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
18. AINO Makoto (20572811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. FUJIMURA Takeki (40749892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. MORITA Hidetoshi (70957294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OZAWA Yusuke (50624326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
22. YOSHIE Hiromasa (20143787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Yoshida Yasuo (10315096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. INAGAKI Koji (50211058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MIKI Takami (90174002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 高柴正悟 (50226768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 永田俊彦 (10127847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 小林哲夫 (00215344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
29. 木戸淳一 (10195315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 大森一弘 (20549860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 前田博史 (00274001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
32. 吉村文信 (50001962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 毛塚雄一郎 (50397163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 天埜克彦 (90231117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 森田一三 (50301635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 川瀬仁史 (60329612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
37. 祖父江尊範 (90319195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 太田浩一 (70262730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 平賀徹 (70322170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 上原俊介 (90434480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 中本哲自 (30514989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 尾崎友輝 (10802902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 鈴木万里代

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 神谷洋介

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. TADA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 松下健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 石田直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 萩原真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 道川誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 西原達次

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

ISHIHARA Yuichi 石原 裕一

Research Projects

Research Products

Co-Researchers

血清中IL-1受容体補助タンパク濃度を用いた新規歯周病病態マーカーの開発Principal InvestigatorOngoing

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破骨細胞によるスクレロスチン分泌制御を基盤とした新規歯周治療薬の開発Ongoing

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Elucidation of molecular basis for the relationship between periodontal disease and atherosclerosis by controlling agingOngoing

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Association subtype of age-relrated macular degeneration and periodontal diseaseOngoing

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Clofibrate produce IL-1Ra and inhibit the experimental periodontitisPrincipal Investigator

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Effect of IL-1Ra in periodontal tissue destruction with IL-1Ra-deficient micePrincipal Investigator

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Effect of the IL-1 typeIIreceptor to a experimental periodontitis infected with periodontal bacteriumPrincipal Investigator

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A function of soluble Interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator

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ISHIHARA Yuichi 石原裕一