• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

ISHIHARA Yuichi  石原 裕一

ORCIDConnect your ORCID iD *help
Researcher Number 50261011
Other IDs
External Links
Affiliation (Current) 2022: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長
Affiliation (based on the past Project Information) *help 2022: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), その他部局等, その他
2019 – 2021: 公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 研究開発室長
2013 – 2018: 松本歯科大学, 歯学部, 教授
2007 – 2013: Aichi Gakuin University, 歯学部, 准教授
2000 – 2006: 愛知学院大学, 歯学部, 講師
1994 – 1999: 愛知学院大学, 歯学部, 助手
1998: 助手
Review Section/Research Field
Principal Investigator
Conservative dentistry / Periodontal dentistry / Periodontal dentistry / Basic Section 57030:Conservative dentistry-related / 病態科学系歯学(含放射線系歯学) / Periodontology
Except Principal Investigator
Periodontal dentistry / Basic Section 57030:Conservative dentistry-related / Periodontology / Morphological basic dentistry / Conservative dentistry / Periodontal dentistry / Ophthalmology
Keywords
Principal Investigator
IL-1 / 歯肉溝滲出液 / インターロイキン-1 / 破骨細胞 / TIMP / 実験的歯周炎 / LPS / Actinobacillus actinomycetemcomitans / インターロイキン-1レセプターアンタゴニスト / インターロイキン1 … More / 侵襲性歯周炎 / 歯周病 / 炎症性骨吸収 / インターロイキンー1 / IL-1Ra / juvenile periodontitis / 早期発症型歯周炎 / IL-1β / gingival crevicular fluid / ELISA / インターロイキン-1ra / 骨髄細胞培養系 / インターロイキン1レセプターアンタゴニスト / 急速進行性歯周炎 / GCF / インターロイキン1レセプターアンタゴニニスト / 歯肉溝浸出液 / インターロイキンー1 / 可溶性インターロイキンー1タイプ2レセプター / インターロイキンー1β / 可溶性IL-1タイプ2レセプター / 遺伝子多型 / マウス歯肉上皮細胞 / インターロイキンー4 / インターフェロンーγ / インターロイキン-1β / 歯周免疫機能学 / インターロイキン-1タイプIIレセプター / IL-1Ra欠損マウス / 炎症性サイトカイン / 実験的歯周炎モデル / IL-1Ra KOマウス / Type II IL-1 receptor / IL-1 receptor antagonist / ELISA法 / 破骨細胞形成 / Tepe II IL-1 receptor / インターロイキンー1レセプターアンタゴニスト / 遺伝子改変マウス / サイトカイン / 歯周治療薬 / インターロイキンー1Ra / 遺伝子欠損マウス / 骨吸収因子 / A. actinomycetemcomitans / TNF-α / IL-6 / 骨関連遺伝子 / 骨芽細胞 / 接着分子 / RNA干渉 / 若年性歯周炎 / マウス骨髄培養系 / マウス骨髄細胞培養系 / osteoclast-like cell / IL-1ra / 成人性歯周炎 / IL-1α / rapidly progressive periodontitis / adult periodontitis / Interleukin-1 / peripheral blood lymphocyte / 莢膜多糖抗原 / 樹状細胞 / 血清抗体価 / Interleukin-6 / OIP-1 / A.actinomycetemcomitans / 歯肉線維芽細胞 / Interleukin-8 / リポ多糖 / Actinobacillus actinomycetemcomitans_ / polysaccharide / interleukin-6 / interleukin-8 / periodontitis / HGF / IL-1receptor type 2 / 慢性歯周炎 / IL-1receptor type2 / soluble interleuklin-1receptor type 2 / chronic periodontitis / interleukin-1β / aggressive periodontitis / クロフィブラート / 高脂血症治療薬 / インターロイキンレセプターアンタゴニスト / 歯周治療 / インターロイキン1 / インターロイキン1レセプターアンタゴニスト / IL-1RAcP / 血清 / 歯周病検査 / インターロイキンー1受容体補助タンパク / 血液検査 … More
Except Principal Investigator
歯周病 / 歯周炎 / 破骨細胞 / 歯学 / 糖尿病 / Actinobacillus actinomycetemcomitans / 骨吸収 / interleukin-1 / periodontal disease / IL-15 / Th1 / OIP-1 / IFN-γ / 動脈硬化症 / メタゲノム解析 / 口腔細菌叢 / 歯周病関連細菌 / ゲノムDNA抽出 / 歯肉縁上プラーク / 歯肉縁下プラーク / 16SrRNA遺伝子解析 / IL-35 / 歯周組織 / Th17 / 免疫学 / IL-17 / プラーク細菌叢 / 臨床株 / 16SrRNA解析 / ゲノム解析 / う蝕細菌 / プラーク細菌 / サイトカイン遺伝子 / 関節リウマチ / 短鎖脂肪酸 / Porphyromonas gingivalis / 酪酸 / 代謝 / 歯周疾患 / 莢膜多糖 / プロスタグランディン / インターロイキン1 / インターロイキン1レセプターアンタゴニスト / 若年性歯周炎 / Actinobocillus actinomycetemcomitans / capsular polysaccharide / bone nesorption / prostagrandin / 粘膜感染 / γδT細胞 / 上皮系サイトカイン / Mucosal infection / γδT cell / IL-1β / Periodontitis / Bone resorption / Osteoclast / 骨粗鬆症 / 骨密度 / 地域歯周疾患指数 / フラクタル次元 / ビスフォスフォネート / osteoporosis / bone mineral density / community periodontal index / fractal dimension / bisphosphonate / 実験的歯周炎 / 拘束ストレス / マイクロアレイ / 遺伝子発現 / experimental periodontitis / restraint stress / microarray / gene expression / 加齢黄斑変性 / 脈絡膜新生血管 / 動脈硬化 / 外科 / 眼科 / 老化制御 / 分子基盤 / スクレロスチン / 骨代謝 / 歯周治療 / 慢性炎症 / 抗老化細胞療法 Less
  • Research Projects

    (28 results)
  • Research Products

    (86 results)
  • Co-Researchers

    (53 People)
  •  高齢者認知機能低下に係る歯周病病態、口腔細菌および口腔機能の影響についての研究Principal Investigator

    • Principal Investigator
      石原 裕一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      The Lion Foundation for Dental Health
  •  慢性炎症が基盤病態の歯周病,糖尿病,動脈硬化症に対する抗老化細胞療法の創出

    • Principal Investigator
      吉成 伸夫
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Matsumoto Dental University
  •  血清中IL-1受容体補助タンパク濃度を用いた新規歯周病病態マーカーの開発Principal Investigator

    • Principal Investigator
      石原 裕一
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      The Lion Foundation for Dental Health
  •  Elucidation of molecular basis for the relationship between periodontal disease and atherosclerosis by controlling aging

    • Principal Investigator
      Yoshinari Nobuo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Matsumoto Dental University
  •  Development of the new periodontal treatments based on the regulation of sclerostin secretion

    • Principal Investigator
      Koide Masanori
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Matsumoto Dental University
  •  Association subtype of age-relrated macular degeneration and periodontal disease

    • Principal Investigator
      Ohta Kouichi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Matsumoto Dental University
  •  Clofibrate produce IL-1Ra and inhibit the experimental periodontitisPrincipal Investigator

    • Principal Investigator
      Ishihara Yuichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontology
    • Research Institution
      Matsumoto Dental University
  •  Elucidation and control of effect of short chain fatty acids on periodontopathogens

    • Principal Investigator
      Yoshida Yasuo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Aichi Gakuin University
  •  An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis

    • Principal Investigator
      YOSHIE Hiromasa
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Periodontology
    • Research Institution
      Niigata University
  •  The role of IL-35 on Th17 cells in inflamed gingiva

    • Principal Investigator
      MITANI Akio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi Gakuin University
  •  Genome sequencing of clinical strains isolated from dental plaque for investigation of polymicrobial factors in periodontal pathogenesis

    • Principal Investigator
      HAYASHI Jun-ichiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi Gakuin University
  •  Effect of IL-1Ra in periodontal tissue destruction with IL-1Ra-deficient micePrincipal Investigator

    • Principal Investigator
      ISHIHARA YUICHI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Matsumoto Dental University
      Aichi Gakuin University
  •  Effect of the IL-1 typeIIreceptor to a experimental periodontitis infected with periodontal bacteriumPrincipal Investigator

    • Principal Investigator
      ISHIHARA Yuichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi Gakuin University
  •  Metagenomic Analysis of Oral Microbiota from Normal Subjects and Patients with Periodontal Disease

    • Principal Investigator
      NOGUCHI Toshihide
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi Gakuin University
  •  A function of soluble Interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator

    • Principal Investigator
      ISHIHARA Yuichi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi Gakuin University
  •  Efficacy of therapy for osteoporosis on oral health

    • Principal Investigator
      INAGAKI Koji
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi-Gakuin Unviersity
  •  The roll of soluble interleukin-1 receptor type 2 for periodontal tissuePrincipal Investigator

    • Principal Investigator
      ISHIHARA Yuichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi-Gakuin university
  •  Effect of restraint stress on the gene expression in periodontal tissue of rat experimental periodontitis

    • Principal Investigator
      YOSHINARI Nobuo
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi-Gakuin University
  •  The working mechanism of bone resorption inhibitory protein induced by osteoclasts

    • Principal Investigator
      NOGUCHI Toshihide
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi-Gakuin University
  •  The effects of the role of cytokine stimulated capsular polysaccharide Actinobacillus actinomycetemcomitans in human gingival fibroblast and monocyte.Principal Investigator

    • Principal Investigator
      ISHIHARA Yuichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Aichi-Gakuin University
  •  The investigation of the role of cytokine from derived epithelial cell for activation γδ T cells in mucosal infection

    • Principal Investigator
      NOGUCHI Toshihide
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi-Gakuin University
  •  The specificity of cytokine production from inflammatory gingivaPrincipal Investigator

    • Principal Investigator
      ISHIHARA Yuichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi Gakuin University
  •  The effect of TIMP on bone resorption and osteoclast like cell formation induced by juvenile periodontitis related bacteriaPrincipal Investigator

    • Principal Investigator
      ISHIHARA Yuichi, 上田 信男
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Aichi-gakuin University
  •  歯周炎患者における歯周組織中のIL-1の相互作用についてPrincipal Investigator

    • Principal Investigator
      石原 裕一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Conservative dentistry
    • Research Institution
      Aichi Gakuin University
  •  マウス骨髄細胞培養系による破骨細胞形成に対するTIMPの役割についてPrincipal Investigator

    • Principal Investigator
      石原 裕一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Conservative dentistry
    • Research Institution
      Aichi Gakuin University
  •  Cell-surface components Actinobacillus actinomycetemcomitans promote osteoclast formation in vitro

    • Principal Investigator
      NOGUCHI Toshihide
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Conservative dentistry
    • Research Institution
      Aichi-gakuin University
  •  歯周炎患者の歯肉溝滲出液中のIL-1とIL-1raの動態に関する研究Principal Investigator

    • Principal Investigator
      石原 裕一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Conservative dentistry
    • Research Institution
      Aichi Gakuin University
  •  歯周炎患者の歯肉溝滲出液中のIL-1とIL-1raの動態に関する研究Principal Investigator

    • Principal Investigator
      石原 裕一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Conservative dentistry
    • Research Institution
      Aichi Gakuin University

All 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] The Regulation of Bone Metabolism and Disorders by Wnt Signaling2019

    • Author(s)
      Maeda K, Kobayashi Y, Koide M, Uehara S, Okamoto M, Ishihara A, Kayama T, Saito M, Marumo K
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Pages: 5525-5525

    • DOI

      10.3390/ijms20225525

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10050, KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-18K16161, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-18H02980, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-17K16706
  • [Journal Article] The KCNQ1 Gene Polymorphism as a Shared Genetic Risk for Rheumatoid Arthritis and Chronic Periodontitis in Japanese Adults: A Pilot Case-Control Study2018

    • Author(s)
      Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
    • Journal Title

      Journal of Periodontology

      Volume: 89(3) Pages: 315-324

    • DOI

      10.1002/jper.17-0412

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K11983, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15764
  • [Journal Article] Periodontitis induced by bacterial infection exacerbates features of Alzheimer‘s disease in transgenic mice.2017

    • Author(s)
      Ishida N, Ishihara Y, Ishida K, Tada H, Funaki-Kato Y, Hagiwara M, Ferdous T, Abdullah M, Mitani A, Michikawa M, Matsushita K.
    • Journal Title

      NPJ Aging Mech Dis.

      Volume: 3 Pages: 15-15

    • DOI

      10.1038/s41514-017-0015-x

    • NAID

      120006576159

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11824, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-17K17362, KAKENHI-PROJECT-26293438, KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-15K15712, KAKENHI-PROJECT-26861586, KAKENHI-PROJECT-16H05559
  • [Journal Article] Adhesion properties of human oral epithelial-derived cells to zirconia.2016

    • Author(s)
      Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Sasaki K, Ban S, Noguchi T, Kawai T, Mitani A.
    • Journal Title

      Clin Implant Dent Relat Res

      Volume: 10 Pages: 906-916

    • DOI

      10.1111/cid.12369

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-16K11845, KAKENHI-PROJECT-26463149
  • [Journal Article] Increased Expression of Interleukin-35 and -17, but not -27, in Gingival Tissues with Chronic Periodontitis.2015

    • Author(s)
      Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T.
    • Journal Title

      J Periodontol

      Volume: 86 Pages: 301-309

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Journal Article] Interleukin-1 receptor antagonist has a novel function in the regulation of matrix metalloproteinase-13 expression.2015

    • Author(s)
      Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0140942

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11402, KAKENHI-PROJECT-26463149, KAKENHI-PROJECT-25253104
  • [Journal Article] Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis2015

    • Author(s)
      Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N, Abe A, Hishikawa T, Mizutani M, Ishihara Y, Nakamura H, Kurita K, Ohno N, Tanaka Y, Hattori M, Noguchi T
    • Journal Title

      J Periodontol

      Volume: 86 Pages: 301-309

    • DOI

      10.1902/jop.2014.140293

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Journal Article] TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1.2014

    • Author(s)
      Kato Y, Hagiwara M, Ishihara Y, Isoda R, Sugiura S, Komatsu T, Ishida N, Noguchi T, Matsushita K.
    • Journal Title

      BMC Microbiology

      Volume: 14 Pages: 229-229

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Journal Article] IL-1 Receptor Type II Production Is Upregulated by IL-4 and IL-13, and Downregulated by IFN-γ in Mouse Gingival Epithelial Cells2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T
    • Journal Title

      Modern Research in Inflammation

      Volume: 3 Pages: 37-47

    • DOI

      10.4236/mri.2014.32005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in Japanese.2014

    • Author(s)
      Kamei H, Ishihara Y, Fuma D, Niwa T, Kamiya Y, Yokoi T, Suzuki M, Izawa A, Mizutani H, Hayashi J, Sakaki Y, Noguchi T, Kojima T.
    • Journal Title

      Arch. Oral Biol.

      Volume: 59 Pages: 756-763

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Journal Article] Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture.2014

    • Author(s)
      Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
    • Journal Title

      Inflammation

      Volume: 37 Pages: 657-669

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
    • Journal Title

      Modern Research in Inflammation

      Volume: 3 Pages: 37-47

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Journal Article] IL-1ファミリーとIL-1受容体:歯周病疾患マーカーや治療薬としての可能性2014

    • Author(s)
      石原裕一,亀井英彦,神谷洋介,伊澤有郎,水谷大樹,鈴木万里代,野口俊英,三谷章雄
    • Journal Title

      日歯周誌

      Volume: 56 Pages: 272-280

    • NAID

      130004842577

    • Data Source
      KAKENHI-PROJECT-24593137
  • [Journal Article] Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in IL-1Ra knockout mice.2014

    • Author(s)
      Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J, Nishihara T, Maeda H, Noguchi T
    • Journal Title

      Infection and Immunity

      Volume: 82 Pages: 1904-1913

    • DOI

      10.1128/iai.01618-13

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-26463149
  • [Journal Article] Interleukin-1 receptor gene variants are associated with aggressive periodontitis in Japanese.2014

    • Author(s)
      Kamei H、Ishihara Y, 12 others
    • Journal Title

      Archives of Oral Biology

      Volume: Vol. 59、No. 7 Pages: 756-763

    • DOI

      10.1016/j.archoralbio.2014.04.006

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23593079, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-25870860
  • [Journal Article] Effect of IL-15 and Natural Killer Cells on Osteoclasts and Osteoblasts in a Mouse Coculture.2014

    • Author(s)
      Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T
    • Journal Title

      Inflammation

      Volume: 37 Pages: 657-669

    • DOI

      10.1007/s10753-013-9782-0

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24792342, KAKENHI-PROJECT-26463149
  • [Journal Article] IL-1 Receptor Type II Production IsUpregulated by IL-4 and IL-13, andDownregulated by IFN-g in Mouse Gingival Epithelial Cells.2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Ozawa Y, Mizutani H, Kubo K, Maeda H, Noguchi T.
    • Journal Title

      Modern Research in Inflammation

      Volume: 3 Pages: 37-47

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Journal Article] Lipopolysaccharide of Aggregati- bacter actinomycetemcomitans upregulates inflammatory cytokines, PGE2 synthesis, and osteoclast formation in IL-1Ra deficient mic2013

    • Author(s)
      Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T.
    • Journal Title

      J Periodont Res

      Volume: 48 Pages: 748-756

    • DOI

      10.1111/jre.12065

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24593134, KAKENHI-PROJECT-24593137, KAKENHI-PROJECT-24659841, KAKENHI-PROJECT-25253104
  • [Journal Article] Effect of IL-15 and natural killer cells on osteoclast and osteoblast in a mouse coculture2013

    • Author(s)
      Takeda H, Kikuchi T, Soboku K, Okabe I, Mizutani H, Mitani A, Ishihara Y, Noguchi T.
    • Journal Title

      Inflammation

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates T cell activation2013

    • Author(s)
      Suga T, Mitani A, Mogi M, Kikuchi T, Fujimura T, Takeda H, Hishikawa T, Yamamoto G, Hayashi J, Ishihara Y, Noguchi T.
    • Journal Title

      Arch Oral Biol

      Volume: 58 Pages: 1541-1548

    • DOI

      10.1016/j.archoralbio.2013.06.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Journal Article] Valproic Acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 12011

    • Author(s)
      Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
    • Journal Title

      Shock

      Volume: 36 Pages: 494-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Journal Article] Degradation of vascular endothelial thrombomodulin by arginine-and lysin-specific cysteine proteases from Porphyromonas gingivalis.2009

    • Author(s)
      Inomata M, Ishihara Y, Matsuyama T, Murayama I, Noguchi T, Matsushita K.
    • Journal Title

      J.Periodontol. 8

      Pages: 1511-1517

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249082
  • [Journal Article] Degradation of vascular endothelial thrombomodulin by arginine-and lysin-specific cysteine proteases from Porphyromonas gingivalis2009

    • Author(s)
      Inomata M, Ishihara Y, Matsuyama T, Murayama I, Noguchi T, Matsushita K
    • Journal Title

      J.Periodontol. 80

      Pages: 1511-1517

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249082
  • [Journal Article] Soluble Interleukin-1 Receptor Type II Levels in Gingival Crevicular Fluid in Aggressive and Chronic Periodontitis2008

    • Author(s)
      Suzuki M, Ishihara.Y, Kamei H, 10名
    • Journal Title

      J Periodontol 79巻

      Pages: 495-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592397
  • [Journal Article] TIMP-1およびTIMP-2は破骨細胞形成を促進する2005

    • Author(s)
      祖父江尊範, 小出雅則, 石原裕一, 野口俊英
    • Journal Title

      日本歯周病学会誌 47(4)

      Pages: 297-308

    • NAID

      10016919077

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390648
  • [Journal Article] Actinobacillus actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells.2005

    • Author(s)
      Iwata T, Mitani A, Ishihara Y et al.
    • Journal Title

      Clin Exp Immuno 141

      Pages: 261-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Actinobacillus actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells2005

    • Author(s)
      Iwata T, Mitani A, Ishihara Y et al.
    • Journal Title

      Clin Exp Immuno 141

      Pages: 261-269

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] A.actinomycetemcomitans Y4 Capsular polysaccharide induces IL-1β mRNA expression through the JNK pathway in differentiated THP-1 cells2005

    • Author(s)
      Iwata T, Mitani A, Ishihara Y, Koide M, Sobue T, Noguchi T
    • Journal Title

      Clin Exp Immuno 141

      Pages: 261-269

    • Data Source
      KAKENHI-PROJECT-15390648
  • [Journal Article] Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response.2004

    • Author(s)
      Al-Darmaki S, Knightshead K, Ishihara Y, et al.
    • Journal Title

      Clin Diagn Lab Immunol 11

      Pages: 720-728

    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6 Zr alloy against MG63 osteoblast like cell.2004

    • Author(s)
      Naganawa T, Ishihara Y, Iwata T. et al.
    • Journal Title

      J Periodontol 75・12

      Pages: 1701-1707

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1 beta in gingival crevicular fluid and gingival tissue.2004

    • Author(s)
      Yoshinari N, Kawase H, Mitani M, Shirozu N., Ishihara
    • Journal Title

      J Periodontal Res 39・3

      Pages: 158-167

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1β in gingival crevicular fluid and gingival tissues.2004

    • Author(s)
      Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T.
    • Journal Title

      Journal of Periodontal Research 39

      Pages: 158-167

    • Data Source
      KAKENHI-PROJECT-16592083
  • [Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6Zr alloy against MG63 osteoblast like cell.2004

    • Author(s)
      Naganawa T, Ishihara Y, Iwata T. et al.
    • Journal Title

      J Periodontol 75

      Pages: 1701-1707

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] 閉経が歯肉溝滲出液中のインターロイキン・1濃度に及ぼす影響2004

    • Author(s)
      夫馬大介, 稲垣幸司, 石原裕一他
    • Journal Title

      日歯周誌 46・4

      Pages: 259-265

    • NAID

      10014078774

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Effect of Menopause on Interleukin-1 Concentration in Gingival Crevicular Fluids2004

    • Author(s)
      Fuma D, Inagaki K, Ishihara Y et al.
    • Journal Title

      J Jpn Soc Periodontol 46

      Pages: 259-265

    • NAID

      10014078774

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues.2004

    • Author(s)
      Yoshinari N, Kawase H, Mitani M, Shirozu N, Ishihara Y et al.
    • Journal Title

      J Periodontal Res 39・3

      Pages: 158-167

    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] In vitro biocompatibility testing of new Ti-29Nb-13Ta-4.6Zr alloy against MG63 osteoblast like cell.2004

    • Author(s)
      Naganawa T, Ishihara Y, Iwata T. et al.
    • Journal Title

      J Periodontol 75・12

      Pages: 1701-1707

    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] 閉経が歯肉溝滲出液中のインターロイキン-1濃度に及ぼす影響2004

    • Author(s)
      夫馬大介, 稲垣幸司, 石原祐一他
    • Journal Title

      日歯周誌 46・4

      Pages: 259-265

    • NAID

      10014078774

    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Delineation of the Role of Platelet-Activating Factor in the Immunoglobulin G2 Antibody Response.2004

    • Author(s)
      Al-Darmaki S, Knightshead K, Ishihara Y et al.
    • Journal Title

      Clin Diagn Lab Immunol 11

      Pages: 720-728

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16592082
  • [Journal Article] Capsular polysaccharide from Actiaobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast.2003

    • Author(s)
      Ohguchi Y, Ishihara Y, Koide M, Noguchi T. et al.
    • Journal Title

      J Periodont Res 38(2)

      Pages: 191-197

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390648
  • [Journal Article] Capsular polysaccharide from Actinobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast.2003

    • Author(s)
      Ohguchi Y, Ishihara Y, Koide M, Noguchi T.
    • Journal Title

      J Periodont Res 38(2)

      Pages: 191-197

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390648
  • [Presentation] 破骨細胞由来のLIFは,sclerostin発現を低下させて骨形成を促進する2018

    • Author(s)
      小出雅則, 尾崎友輝, 中村圭吾, 宇田川信之, 石原裕一, 吉成伸夫
    • Organizer
      日本歯周病学会会誌(Web)
    • Data Source
      KAKENHI-PROJECT-18H02980
  • [Presentation] 歯周組織におけるIL-1Raの役割と治療薬への可能性2017

    • Author(s)
      石原裕一
    • Organizer
      60回春季日本歯周病学会学術大会 学会学術賞記念講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] IL-1Ra欠損マウスでの破骨細胞形成と炎症性骨吸収が亢進する2017

    • Author(s)
      石原裕一,小出雅則,吉成伸夫
    • Organizer
      第2回日本骨免疫学会ウインターセミナ
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] IL-1Ra欠損マウスでは破骨細胞形成と炎症性骨吸収が亢進する2017

    • Author(s)
      石原裕一,小出雅則,吉成伸夫
    • Organizer
      第2回日本骨免疫学会ウインターセミナー
    • Place of Presentation
      ホテルマロウド軽井沢(長野)
    • Year and Date
      2017-01-27
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] The Effect of Serum Amyloid A for Endothelial Cell2016

    • Author(s)
      Yoshinari,N., Takahashi K., Kaise K., Saleem M., Ozaki Y., Nakamura S., Kubokawa K., Ishihara Y.
    • Organizer
      94th General session of the IADR
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2016-06-24
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] 骨吸収はsclerostinの発現低下を介して骨形成を促進する2016

    • Author(s)
      小出雅則、尾崎友輝、吉成伸夫、石原裕一、宇田川信之
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      鹿児島県民交流センター(鹿児島)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] ジルコニアに対するヒト口腔由来上皮細胞の付着特性2015

    • Author(s)
      郎,石原裕一,菊池 毅,伊澤有郎,小林周一郎,後藤久嗣,神谷洋介,伴 清治,野口俊英,河合逹志,三谷章雄
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      浜松 アクトシティ浜松
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] Adhesion properties of human oral epithelial-derived cells to zirconia2015

    • Author(s)
      Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Ban S, Noguchi T, Kawai T and Mitani A
    • Organizer
      第63回国際歯科研究会日本部会総会・学術総会
    • Place of Presentation
      福岡 福岡国際会議場
    • Year and Date
      2015-10-30
    • Data Source
      KAKENHI-PROJECT-15K11402
  • [Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する.2014

    • Author(s)
      後藤久嗣,石原裕一,伊澤有郎,岡部栄治郎,久保勝俊,杉田好彦,前田初彦,野口俊英,三谷章雄
    • Organizer
      秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫)
    • Year and Date
      2014-10-19
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
    • Organizer
      2014 Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      Moscone center, San Francisco, USA
    • Year and Date
      2014-09-19
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] Interleukin-1 receptor antagonist は歯肉上皮細胞からのMatorix metallopeptidase 13 発現を抑制する2014

    • Author(s)
      後藤久嗣,石原裕一,伊澤有郎,岡部栄治郎,久保勝俊,杉田好彦,前田初彦,野口俊英,三谷章雄
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2014-10-19
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients.2014

    • Author(s)
      Kamiya Y, Ishihara Y, Kamei H, Izawa A, Okabe E, Goto H, Kuno A, Sugawa Y, Ozawa Y Mitani A
    • Organizer
      the 100th Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-09-19
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Presentation] High levels of sIL-1RAcP was observed in chronic periodontitis patients2014

    • Author(s)
      Yosuke Kamiya, Yuichi Ishihara, Hidehiko Kamei, Ario Izawa, Eijiro Okabe, Hisashi Goto, Akane Kuno, Yuji Sugawa, Yusuke Ozawa, Akio Mitani
    • Organizer
      2014 Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      San Francisco
    • Year and Date
      2014-09-20
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] インターロイキン1レセプターアンタゴニストのコラゲナーゼ3(MMP-13)発現抑制について2014

    • Author(s)
      後藤久嗣、石原裕一、伊澤有郎、岡部栄次郎、久保勝俊、杉田好彦、前田初彦、野口俊英、三谷章雄
    • Organizer
      第85回愛知学院大学歯学会
    • Place of Presentation
      愛知学院大学楠元キャンパス(愛知)
    • Year and Date
      2014-12-07
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] Interleukin-1 receptor antagonistは歯肉上皮細胞からのMatrix metalo- peptidase 13発現を抑制する2014

    • Author(s)
      後藤久嗣, 石原裕一, 伊澤有郎, 岡部栄治郎, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英, 三谷章雄
    • Organizer
      第57回秋季日本歯周病学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-19
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] 垂直性骨欠損に対し GTR 法とエナメルマトリックスタンパク質を用いた歯周組織再生療法を行った症例の 5 年経過時における臨床的比較2013

    • Author(s)
      相野誠, 三谷章雄, 高須英成, 古田英豊, 永坂太郎, 三輪晃資, 菊池毅, 川瀬仁史, 伊藤正満, 林潤一郎, 黒須康成,石原裕一, 稲垣幸司, 福田光男, 野口俊英.
    • Organizer
      日本歯科保存学会春期学術大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響2013

    • Author(s)
      後藤久嗣,石原裕一,伊澤有郎,岡部栄治郎,久保勝俊,杉田好彦,前田初彦,野口俊英
    • Organizer
      第56回秋季日本歯周病学会
    • Place of Presentation
      前橋市市民文化会館(前橋市)
    • Year and Date
      2013-09-22
    • Data Source
      KAKENHI-PROJECT-25253104
  • [Presentation] 歯周病関連細菌Porphyromonas gingivalisの歯肉上皮細胞への侵入機構の解明2011

    • Author(s)
      加藤佳子, 杉浦進介, 小松寿明, 石原裕一, 野口俊英, 松下健二
    • Organizer
      第54回春季日本歯周病学会
    • Place of Presentation
      福岡
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] IL-1Ra欠損マウスを用いたA. actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現2011

    • Author(s)
      伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
    • Organizer
      第54回秋季日本歯周病学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] ヒト歯周病細菌叢のメタゲノム解析2011

    • Author(s)
      林潤一郎,近藤伸二、亀井英彦、森田英利、足立直樹、福田光男、Todd D Taylor、石原裕一、小島俊男、野口俊英
    • Organizer
      第5回日本ゲノム微生物学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-03-14
    • Data Source
      KAKENHI-PROJECT-20249082
  • [Presentation] プラーク細菌叢のメタゲノム解析2011

    • Author(s)
      林潤一郎、亀井英彦、福田光男、石原裕一、野口俊英
    • Organizer
      第54回秋季日本歯周病学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] IL-1Ra欠損マウスを用いたA.actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現2011

    • Author(s)
      伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
    • Organizer
      第54回秋季日本歯周病学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] IL-1Ra欠損マウスの破骨細胞形成能と実験的歯周炎について2011

    • Author(s)
      石原裕一, 水谷大樹, 伊澤有郎, 三谷章雄, 黒須康成, 川瀬仁史, 稲垣幸司, 野口俊英
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] IL-1Ra欠損マウス腹腔マクロファージにおける骨吸収活性の解析2011

    • Author(s)
      水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 久保勝俊, 西原達次, 前田初彦, 野口俊英
    • Organizer
      第3回口腔先端応用医科学研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-01-22
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] IL-1RaKOマウス腹腔マクロファージを用いた破骨細胞形成能と骨吸収活性の解析2011

    • Author(s)
      水谷大樹, 石原裕一, 藤原祐子, 伊澤有郎, 小澤佑介, 神谷洋介, 近藤久貴, 西原達次, 戸刈彰史, 野口俊英
    • Organizer
      第54回秋季日本歯周病学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] IL-32 IN GINGIVAL CREVICULAR FLUIDS AND GINGIVAL TISSUE FROM PERIODONTITIS PATIENTS2010

    • Author(s)
      Y.Ishihara
    • Organizer
      第96回アメリカ歯周病学会
    • Place of Presentation
      ハワイコンベンションセンター(ハワイ)
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] ラット実験的歯周炎における破骨細胞形成とIL-1ファミリーの動態2010

    • Author(s)
      小澤佑介, 石原裕一, 水谷大樹, 伊澤有郎, 亀井英彦, 田中繁寿, 林潤一郎、三谷章雄, 神谷洋介, 西原達次, 前田初彦, 野口俊英
    • Organizer
      第53回秋季日本歯周病学会
    • Place of Presentation
      高松
    • Year and Date
      2010-09-19
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] Metagenomic analysis of the dental plaque2010

    • Author(s)
      Hayashi J, Kondo S, Morita H, Kamei H, Fukuda M, Ishihara Y, Kojima T, Noguchi T
    • Organizer
      96^<th> American Academy of Periodotology Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-11-02
    • Data Source
      KAKENHI-PROJECT-20249082
  • [Presentation] IL-1RaKOマウス腹腔マクロファージからのIL-1産生亢進2010

    • Author(s)
      水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野誠、神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 西原達次, 前田初彦, 野口俊英
    • Organizer
      第53回秋季日本歯周病学会
    • Place of Presentation
      高松
    • Year and Date
      2010-09-19
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cell2009

    • Author(s)
      Y. Ishihara, Y. Kamiya, Y. Ozawa, A. Nagahara, H. Mizutani, S. Tanaka, H. Kamei, T. Noguchi
    • Organizer
      The 95th annual meeting of the American Academy of Periodontology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-09-14
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] 歯周病におけるIL-1の働き2009

    • Author(s)
      石原裕一
    • Organizer
      再生補綴医学研究会・第2回学術会議
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cells2009

    • Author(s)
      石原裕一
    • Organizer
      The 95^<th> annual meeting of the American Academy of Periodontology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-09-14
    • Data Source
      KAKENHI-PROJECT-21592638
  • [Presentation] 歯周病におけるIL-1レセプターtypeIIの働きについて2008

    • Author(s)
      石原裕一, 11名
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-15
    • Data Source
      KAKENHI-PROJECT-19592397
  • [Presentation] Osteoclast differentiation and function is inhibited by Ca^<2+> channel blocker, diphenylhydantoin(DPH).2007

    • Author(s)
      Ishihara Y
    • Organizer
      The 93nd annual meeting of the American Academy of Periodontology
    • Place of Presentation
      Washington, D. C. USA
    • Data Source
      KAKENHI-PROJECT-19592397
  • [Presentation] IL-1RaKOマウスにおける骨代謝の低下

    • Author(s)
      伊澤 有郎,石原裕一,水谷大樹,小林周一郎,小澤佑介,神谷洋介,久保勝俊,杉田好彦,前田初彦,野口俊英
    • Organizer
      第80回愛知学院大学歯学会学術大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] Serum sIL-1RAcP levels are correlated with periodontal disease severity

    • Author(s)
      Y Ishihara, H Mizutani, A Izawa, E Okabe, H Goto, Y Ozawa, M Aino, H Kamei, A Mitani, J Hayashi, K Inagaki, M Fukuda, T Noguchi
    • Organizer
      98TH Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
    • Place of Presentation
      Los Angeles, USA
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] IL-1Receptor antagonist のRNA干渉がヒト歯肉上皮細胞の接着分子発現へ及ぼす影響

    • Author(s)
      後藤久嗣,石原裕一,伊澤有郎,岡部栄治郎,久保勝俊,杉田好彦,前田初彦,野口俊英
    • Organizer
      第56回秋季日本歯周病学会
    • Place of Presentation
      前橋(群馬)
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] 歯周炎患者における末梢血血清中のsIL-1RAcPと臨床所見との関係

    • Author(s)
      水谷大樹,石原裕一,伊澤有郎,小澤佑介,相野 誠,亀井英彦,三谷章雄,林潤一郎,稲垣幸司,福田光男,野口俊英
    • Organizer
      第55回春季日本歯周病学会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] The Effect of Interleukin-15 on Inflammatory Bone Metabolism

    • Author(s)
      Akio MITANI, Hiroaki TAKEDA, Takeshi KIKUCHI, Kyoko SOBOKU, Sachiko FUJITA, Yuichi ISHIHARA, Toshihide NOGUCHI
    • Organizer
      EUROPEAN CONGRESS OF IMMUNOLOGY
    • Place of Presentation
      Glasgow, Scotland, UK
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] 末梢血血清中の可溶性インターロイキン-1補助タンパクの歯周病マーカーとしての可能性

    • Author(s)
      小澤佑介,石原裕一,亀井英彦,水谷大樹,伊澤有郎,岡部栄治郎,後藤久嗣,久野 茜,須川雄司,猪子将成,神谷洋介,野口俊英
    • Organizer
      第8回日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
    • Place of Presentation
      松本(長野)
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] Characteristics of Epithelial cell attachment to zirconia similar to titanium

    • Author(s)
      Ishihara Y, Okabe E, Sasaki K, Kobayashi S, Mizutani H, Izawa A, Goto H, Murakami H, Ban S, Kawai T, Noguchi T
    • Organizer
      the 2nd Meeting of the International Association for Dental Research Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] A.actinomycetemcomitans菌刺激したIL-1Ra欠損マウス由来骨芽細胞の造骨系骨関連遺伝子発現

    • Author(s)
      伊澤 有郎,石原裕一,水谷大樹,小林周一郎,小澤佑介,神谷洋介,久保勝俊,杉田好彦,前田初彦,野口俊英
    • Organizer
      第55回春季日本歯周病学会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24593137
  • [Presentation] IL-15 の炎症性骨代謝に対する影響

    • Author(s)
      武田紘明, 菊池 毅, 惣ト響子, 相野 誠, 三谷章雄, 石原裕一, 野口俊英
    • Organizer
      第 55 回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] 歯周炎患者における末梢血血清中の sIL-1RAcP と臨床所見の関係

    • Author(s)
      水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野 誠, 亀井英彦, 三谷章雄, 林潤一郎, 稲垣幸司, 福田光男, 野口俊英
    • Organizer
      第 55 回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24593134
  • [Presentation] 骨縁下欠損に対するエナメルマトリックスタンパク質を応用した歯周組織再生療法5年経過症例の臨床的検討

    • Author(s)
      三谷章雄,高須英成,吉成伸夫,伊藤正満,川瀬仁史,相野誠,林潤一郎,稲垣幸司,黒須康成,三輪晃資,石原裕一,福田光男,野口俊英
    • Organizer
      第136回日本歯科保存学会春季学術大会
    • Place of Presentation
      沖縄
    • Data Source
      KAKENHI-PROJECT-24593134
  • 1.  MITANI Akio (50329611)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 33 results
  • 2.  YOSHINARI Nobuo (20231699)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 3.  NOGUCHI Toshihide (50014262)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 31 results
  • 4.  KOIDE Masanori (10367617)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 9 results
  • 5.  KAMEI Hidehiko (50421243)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 9 results
  • 6.  TAGUCHI Akira (70243582)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  TANAKA Shigehisa (30367619)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 8.  OHGUCHI Masahiro (00319196)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  宇田川 信之 (70245801)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 10.  HAYASHI Junichiro (30350937)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 11.  MORITA Hidetoshi (70257294)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 12.  HATTORI Masahira (70175537)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  UEDA Nobuo (30291769)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  尾崎 友輝 (10802902)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  KOJIMA Toshio (00311340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  FUKUDA Mitsuo (40156790)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 17.  TOH Hidehiro (10353468)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  KIKUCHI Takeshi (40421242)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 19.  AINO Makoto (20572811)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 20.  FUJIMURA Takeki (40749892)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 21.  MORITA Hidetoshi (70957294)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  OZAWA Yusuke (50624326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 23.  YOSHIE Hiromasa (20143787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  Yoshida Yasuo (10315096)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  INAGAKI Koji (50211058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MIKI Takami (90174002)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  Ohta Kouichi (70262730)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  高柴 正悟 (50226768)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  永田 俊彦 (10127847)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  小林 哲夫 (00215344)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 31.  木戸 淳一 (10195315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  大森 一弘 (20549860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  前田 博史 (00274001)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 34.  吉村 文信 (50001962)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  毛塚 雄一郎 (50397163)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  天埜 克彦 (90231117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  森田 一三 (50301635)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  川瀬 仁史 (60329612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 39.  祖父江 尊範 (90319195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  平賀 徹 (70322170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  上原 俊介 (90434480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 42.  中本 哲自 (30514989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  鈴木 万里代
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  神谷 洋介
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  TADA Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  MAEDA Kazuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  西原 達次
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 48.  松下 健二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  石田 直之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  萩原 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  道川 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  小林 泰浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  嘉山 智大
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to connect your ORCID iD to this researcher?
* This action can be performed only by the researcher themselves.

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi