MIYAUCHI Seiji 宮内正二

Researcher Number	30202352
Other IDs
Affiliation (Current)	2025: 東邦大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2024: 東邦大学, 薬学部, 教授 2008 – 2010: Matsuyama University, 薬学部, 教授 2007: Hokkaido University, Grad School of Pharm, Associate Professor 2006: Hokkaido University, Faculty of Pharmaceutical Sciences, Associate Professor, 大学院薬学研究院, 助教授 1998 – 2005: 北海道大学, 大学院・薬学研究科, 助教授 … More 1998: 北海道大学, 大学院薬学研究科, 助教授 1994 – 1997: Hokkaido University, Faculty of Pharmaceutical Sciences, lecturer, 薬学部, 講師 1992 – 1993: 北海道大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Physical pharmacy / Physical pharmacy / Functional biochemistry / Basic Section 43040:Biophysics-related / Environmental pharmacy / Biological pharmacy / Living organism molecular science / 光生命科学 / Science and Engineering
Keywords	Principal Investigator トランスポーター / 分子弁 / 起電性輸送担体 / 水素結合ネットワーク / Haloferax volcanii / amino acid-induced MDR / アルブミン結合解離 / 蛍光相関分光測定 / アルブミン促進取り込み機構 / SMCT … More / モジュレーター / 輸送サイクル / ハロロドプシン / 光駆動性イオンポンプ / ATP binding cassette / glucose-induced MDR / matabolic stress / 多剤耐性 / IVIVE / 蛍光相関分光測定法 / アルブミン解離促進 / アルブミン促進肝取り込み / 滴定型熱量測定 / 組織移行性 / アルブミン結合解離促進 / 起電性 / 多様性 / 輸送方向性 / 基質認識能力 / 機能リポジショニング / 多彩な基質認識能 / チャネル / transporter / Chloride pump / electrophysiology / two-electrode voltage clamp method / Xenopus oocyte / halorhodopsin / oligopeptide transporter / オリゴペプチヂ輸送担体 / クロライドポンプ / 電気生理学 / 二電極電位固定法 / アフリカツメガエル卵母細胞 / オリゴペプチド輸送担体 / 基質認識機構 / pKaシフト / オリゴペプチドトランスポーター / レチナール / 膜タンパクの結晶化 / シッフ塩基 / イオンポンプ / レチナールタンパク / 電気生理 / スイッチ機構 / 輸送分子機構 / 生物物理化学 / 膜蛋白 / MDR / 大量発現 / 多剤排出輸送担体 / ABC輸送担体 / 高度好熱菌 / Haloferax volcanll / matabollc stress / metabolic stress / ATP binding cassette, / glucose-lnduced MDR / アミノ酸 / 抗ガン剤排出 / P-glycoprotein / 代謝ストレス / 古細菌 / 能動輸送 / P-糖タンパク … More Except Principal Investigator フォトサイクル / Haloferax volcanii / レチナール / 微生物ロドプシン / イオンポンプ / 高度好塩菌 / ハロロドプシン / レチナールタンパク / 走光性 / フォボロドプシン / ロ-ダミン123 / Enterococcus hirae / Natronobacterium pharaonis / 膜輸送 / phoborhodopsin / 等温滴定型熱量計 / sensory rhodopsin / pharaonis phoborhodopsin / archaeal rhodopsin / SVD / CFU / S / UVC / バクテリオロドプシン / 吸収波長 / ファラオニスフォボロドプシン / PEPT1 / 多剤排出輸送体 / Caco-2 / 抗ガン剤 / グルコース / ドキソルビシン / P-glycoprotein / ナトリウムポンプ / ロドプシン / 膜蛋白質 / アニオンポンプ / センソリーロドプシン / トランスジューサ / EmrE / エンドサイトーシス / リポソーム / 滴定型カロリメトリー / NMR / metabolic stress / Corynebacterium glutamicum / 多剤耐性 / P-糖タンパク / ナノディスク / 過渡吸収分光法 / Photo-taxis / Isothermal titration Calorimetry / Transparent electrode / Retinal / Halobacteria / Sensory rhodopson / Phoborhodopsn / Microbial rhodopson / Natronobacterium / Natronomus pharaonis / トランスジューサー / 古細菌ロドプシン / HtrII / Natronomonas pharaconis / FTIR / ITC / 透明電極 / retinal protein / color regulation / bacteriorhodopsin / flash photolysis / halobacterial transducer / photocycle / 光化学中間体 / ヒドロキシルアミン / 呼吸波長 / 膜タンパク構造維持 / Halobacterium halobium / 膜タンパク安定性 / 固体NMR / バクテリオロドプシ / 波長制御 / Archaeal rhodopsin / アーカエアルロドプシン / ハロバクテリアルトランスジューサ / DNA damage / Hemoglobin / D treatment / Heat treatment of virus / UV-irradiation / parvovirus / 血液凝固第8因子 / B19 / 一重項酸素 / 血液凝固第VIII因子 / 6-4付加体 / ピリミジンダイマー / 活性酸素 / メチレンブルー / カテキン / ヒトパルボウイルスB19 / DNA障害 / ヘモグロビン / D法 / ウイルスの熱処理 / 紫外線照射 / パルボウイルス / schiff base / the decay rate of photo-intermediate / M-intermediate / absorption wavelength / bacteriorhodosin / expression system / 分子動力学計算 / 大腸菌での発現系 / ph測定 / プロトンの移動 / 発現系の構築 / シッフ塩基 / 光化学中間体の崩壊の速度 / M中間体 / バクテリオバクテリオロドプシン / 発現系 / hexokinase / glucose / ethidium / doxorubicin / Bacillus subtilis / Enteroccus hirae / ABC super family / 大腸菌 / Halobacterium volcaii / PCR / ATP binding casette(ABC) / ABC transporter / MDR(multi-drug resistance) / Thermus thermophilus / ヘキソキナーゼ / エチジュウム / 枯草菌Bacillus subtilis / 腸内連鎖球菌Enterococcus hirae / ABCスーパーファミリー / 高度好塩菌Haloferax volcanii / anti-cancer drugs / multi-efflux transporter / methoxylate / fluorescent substrate / Peptide transporter / フローレセッイン / ピレン / 平面脂質二分子膜 / リゾリン脂質 / 腸管吸収 / ザルコシン / Sw620 / Caco2 / FITC / ダイペプチド / 蛍光性輸送基質 / メトキサレート / 蛍光生輸送基質 / ペプチドトランスポータ / Glucose / Fructose / Phodamine 123 / Anti-cancer reagents / Multi-drug resistance / プロベネシド / フルクトース / Ca-拮抗剤 / P-glycoprotein(Pgp) / 抗ガン剤排出タンパク / Escherichia coli / フラクトース / 膜タンパク質 / C1イオン結合 / 卵母細胞 / 3量体形成 / ハロロドプシン(halorhodopsin) / Natronomonaa pharaonis / Clイオン結合 / フラッシュフォトリシス / halorhodopsin / Natronomonas Pharaonis / ホトサイクル / 解離定数 / MALDI-TOF / dodecy1-β-D-maltoside / C1輸送 / Circular Dichroism / exciton-coupling / 閃光光分解 / オーサイト / PRET / Natronmonas pharaonis / 多剤排出ポンプ / 光イオンポンプ / 光レセプター / Natronomonas pharaonis / Natromonus pharaonis / 水素結合 / 蛋白間相互作用 / linker resion / sensory rhodopsi / halobacterial transducer protein / 脂溶性フォスフォニウムイオン / エントロピー / エンタルピー / 溶離曲線の分散 / tetraphenylboron / tetraphenylphosphonium / 疎水性相互作用 / 吸着の熱力学量 / リポソームカラム / 滴定型熱量計 / 遺伝子デソバソー / 核局在化シグナル / 核膜 / 核膜融合モデル / ポリエチレンイミン / 遺伝子ベクター / 核移行シグナル / レセプター / 耐性 / シンクロナイゼーション / エンドソーム / GALA / トランスフェリン / 分子シンクロナイゼーション / ターゲティング / 薬物送達システム / Scatchardプロット / 脂肪酸 / Clイオンの結合 / ワルファリン / リン酸の結合阻害 / nucleotideの結合阻害 / BSA / photo-affinity labeling / 熱力学量の変化 / 吸着 / ATP / アルプミン / ATP駆動薬物排出ポンプ / 多剤排出 / カタボライト抑制 / グルコース効果 / 薬物排出輸送体 Less

Physiological significance of the albumin-facilitated transport: Clarification on the facilitated dissociation on the cell surfacePrincipal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Toho University
過渡現象解析で追求する膜輸送タンパク質の多段階構造変化と輸送素過程の連関
- Principal Investigator
  
  菊川峰志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Hokkaido University
Elucidation of the molecular mechanism by the albumin-mediated hepatic uptake and new development of the mechanistic model to describe the albumin-mediated phenomenonPrincipal Investigator
- Principal Investigator
  
  Miyauchi Seiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Toho University
Elucidation of molecular mechanism by which a transporter with a potential to transport a variety of substrates is regulatedPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Seiji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Toho University
Analysis of elementary processes in the photocycle of sodium ion-pumping rhodopsin and an attempt to expand the substrate ion
- Principal Investigator
  
  Kikukawa Takashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Study on the physiological significance and the molecular mechanism of Na+-pumping rhodopsin
- Principal Investigator
  
  Kikukawa Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Elucidation of the molecular valve in the transporter to determine the direction of the transporter cyclePrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Seiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Toho University
Analysis of the elementary processes in the light-driven Cl- pump of halorhodopsin
- Principal Investigator
  
  KIKUKAWA Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Hokkaido University
Characterization of molecular mechanism of electrogenic transporters accompanying ion movementPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Seiji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Toho University
A developmental approach to clarify a molecular mechanism of transporter utilizing a model transporter as a light-driven ion pumpPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Seiji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Matsuyama University
Elucidation of Cl--pumping mechanism and significance of trimer formation of halorhodopsin
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Molecular mechanisms in light-driven anion pump of halorhodopsin
- Principal Investigator
  
  KIKUKAWA Takashi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  光生命科学
- Research Institution
  Hokkaido University
膜タンパク複合体の構造形成および機能発現の生物物理化学
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
A new approach to investigate on electrogenic transporters with Xenopusoocyte expression systemPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Seiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
膜蛋白から膜蛋白へどのようにして情報が伝達されるのか?
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Signal transduction via membrane protein complex : photo-signal transduction of Halobacterium salinarum
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Biophysical Chemistry on photobrhodopsin, a sensor for a negative taxis of Halobacterium
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
核ターゲティングの新戦略:核膜の特殊性に基づいた標的化
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
脂溶性薬物の脂質2分子膜への吸着は「非古典的疎性水相互作用」か?
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Physical and/or Chemical Methods for the Removal of Virus from Transfusion Blood
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
選択的抗腫瘍システムの開発を目指した細胞内動態の分子シンクロナイゼーション
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
高度好熱菌における動物細胞MDR類似輸送担体の機能解析Principal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
PHYSICO-CHEMICAL STUDY ON PHARAONIS PHOBORHODOPSIN USING ITS RECOMBINANT PROTEIN
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
バクテリアにおける、大過剰量グルコースによる薬物排出輸送担体の誘導機構の解明Principal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
強いATPの血清アルプミンへの吸着の生理的意義は何か
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
バクテリアにおけるATP駆動薬剤排出トランスポータに関する研究
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
高度好塩菌における、代謝などのストレス負荷により誘導される抗癌剤排出蛋白の同定Principal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Physicochemical Studies on multi-drug Efflux Transporters of Bacteria
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
バクテリアにおけるATP駆動薬剤排出トランスポータに関する研究
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
高度好塩菌における、代謝などのストレス負荷により誘導される抗癌剤排出蛋白の同定Principal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Drug Delivery System Utilizing Transporters That Recognize Substrates of Relatively Large Molecular Sizes
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
古細菌の一種、高度好塩菌に存在する抗癌剤排出蛋白の発現調節及び基質の検討Principal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
古細菌の一種、高度好塩菌に存在する抗癌剤排出蛋白の分離精製及びその排出機構の解明Principal Investigator
- Principal Investigator
  
  宮内正二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Study on membrane transport of halobacterial cells used as model cells for the transport investigation of pharmaceutical agents
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University

[Book] 「薬剤学実験法マニュアルII」日本薬剤学会出版委員会編,第3章(薬物吸収)1節(経口投与)3項「In vivo実験」2014
- Author(s)
  宮内正二
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23590062
[Book] 薬剤学実験法マニュアルII2014
- Author(s)
  宮内正二
- Total Pages
  7
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23590062
[Book] 「パートナー薬剤学」寺田勝英,伊藤智夫編,第4章5節「薬物の排泄」2012
- Author(s)
  宮内正二
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23590062
[Journal Article] Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells2024
- Author(s)
 Takiguchi Takaharu、Sugio Kazuaki、Masuda Masayuki、Sasaki Shotaro、Miyauchi Seiji
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 47 Issue: 1 Pages: 79-87
- DOI
 10.1248/bpb.b23-00570
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2024-01-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K06519
[Journal Article] Elucidation of a Thermodynamical Feature Attributed to Substrate Binding to the Prokaryotic H+/Oligopeptide Cotransporter YdgR with Calorimetric Analysis: The Substrate Binding Driven by the Change in Entropy Implies the Release of Bound Water Molecules from the Binding Pocket2023
- Author(s)
  Akiko Omori, Shotaro Sasaki, Takashi Kikukawa, Kazumi Shimono, and Seiji Miyauchi
- Journal Title
  
  Biochemistry
  
  Volume: - Issue: 11 Pages: 1608-1618
- DOI
  10.1021/acs.biochem.2c00673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06519, KAKENHI-PROJECT-21K15323, KAKENHI-PUBLICLY-22H05389, KAKENHI-PROJECT-23K23843
[Journal Article] Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo2022
- Author(s)
  Seiji Miyauchi, Soo-Jin Kim, Wooin Lee, Yuichi Sugiyama
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 229 Pages: 107938-107938
- DOI
  10.1016/j.pharmthera.2021.107938
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06519
[Journal Article] Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity2021
- Author(s)
  Akiko Omori, Yuki Fujisawa, Shotaro Sasaki, Kazumi Shimono, Takashi Kikukawa, Seiji Miyauchi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 5 Pages: 678-685
- DOI
  10.1248/bpb.b20-01013
- NAID
  130008033231
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-18K14962, KAKENHI-PROJECT-19K07549
[Journal Article] Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina2021
- Author(s)
  Sudha Ananth, Seiji Miyauchi, Muthusamy Thangaraju, Ravirajsinh N Jadeja, Manuela Bartoli, Vadivel Ganapathy, Pamela M Martin
- Journal Title
  
  Antioxidants
  
  Volume: 10(1) Issue: 1 Pages: 9-9
- DOI
  10.3390/antiox10010009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06608
[Journal Article] Transport Characteristics of 5-Aminosalicylic Acid Derivatives Conjugated with Amino Acids via Human H+-Coupled Oligopeptide Transporter PEPT12020
- Author(s)
 Tatsushi Yuri, Yusuke Kono, Tomofumi Okada, Tomohiro Terada, Seiji Miyauchi, Takuya Fujita
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 43 Issue: 4 Pages: 697-706
- DOI
 10.1248/bpb.b19-01048
- NAID
 130007825299
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2020-04-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-17K08430, KAKENHI-PROJECT-20K07190
[Journal Article] Transport Mechanisms for the Nutritional Supplement β-Hydroxy-β-Methylbutyrate (HMB) in Mammalian Cells2019
- Author(s)
  Ogura Jiro、Sato Toshihiro、Higuchi Kei、Bhutia Yangzom D.、Babu Ellappan、Masuda Masayuki、Miyauchi Seiji、Rueda Ricardo、Pereira Suzette L.、Ganapathy Vadivel
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 36 Issue: 6 Pages: 84-84
- DOI
  10.1007/s11095-019-2626-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06608
[Journal Article] Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8)2019
- Author(s)
  Sugio Kazuaki、Inoda Daisei、Masuda Masayuki、Azumaya Isao、Sasaki Shotaro、Shimono Kazumi、Ganapathy Vadivel、Miyauchi Seiji
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 34 Issue: 1 Pages: 95-103
- DOI
  10.1016/j.dmpk.2018.10.004
- NAID
  50014558504
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-18K14962
[Journal Article] Photochemical study of a cyanobacterial chloride-ion pumping rhodopsin2019
- Author(s)
  Hasemi Takatoshi、Kikukawa Takashi、Watanabe Yumi、Aizawa Tomoyasu、Miyauchi Seiji、Kamo Naoki、Demura Makoto
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1860 Issue: 2 Pages: 136-146
- DOI
  10.1016/j.bbabio.2018.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07326, KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-16K14044
[Journal Article] Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12).2019
- Author(s)
  Srivastava S, Nakagawa K, He X, Kimura T, Fukutomi T, Miyauchi S, Sakurai H, Anzai N.
- Journal Title
  
  J Physiol Sci
  
  Volume: 69 Issue: 2 Pages: 399-408
- DOI
  10.1007/s12576-018-00658-1
- NAID
  40021819085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08200, KAKENHI-PROJECT-18K06608
[Journal Article] Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the “Albumin-Mediated” Hepatic Uptake Mechanism on the Basis of the “Facilitated-Dissociation Model”2018
- Author(s)
  Kim Soo-Jin、Lee Kyeong-Ryoon、Miyauchi Seiji、Sugiyama Yuichi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 47 Issue: 2 Pages: 94-103
- DOI
  10.1124/dmd.118.083733
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-19H03392
[Journal Article] Interhelical interactions between D92 and C218 in the cytoplasmic domain regulate proton uptake upon N-decay in the proton transport of Acetabularia rhodopsin II2018
- Author(s)
  Tamogami Jun, Kikukawa Takashi, Ohkawa Keisuke, Ohsawa Noboru, Nara Toshifumi, Demura Makoto, Miyauchi Seiji, Kimura-Someya Tomomi, Shirouzu Mikako, Yokoyama Shigeyuki, Shimono Kazumi, Kamo Naoki
- Journal Title
  
  Journal of Photochemistry and Photobiology B: Biology
  
  Volume: 183 Pages: 35-45
- DOI
  10.1016/j.jphotobiol.2018.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08296, KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-16K18519
[Journal Article] Formation of M-Like Intermediates in Proteorhodopsin in Alkali Solutions (pH less than 8.5) Where the Proton Release Occurs First in Contrast to the Sequence at Lower pH2016
- Author(s)
  Tamogami J, Sato K, Kurokawa S, Yamada T, Nara T, Demura M, Miyauchi S, Kikukawa T, Muneyuki E, Kamo N
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 7 Pages: 1036-1048
- DOI
  10.1021/acs.biochem.5b01196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460044, KAKENHI-PUBLICLY-26103528
[Journal Article] X-ray crystallographic structure of thermophilic rhodopsin: implications for high thermal stability and optogenetic function2016
- Author(s)
  Tsukamoto T, Mizutani K, Hasegawa T, Takahashi M, Honda N, Hashimoto N, Shimono K, Yamashita K, Yamamoto M, Miyauchi S, Takagi S, Hayashi S, Murata T, Sudo Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: in press Issue: 23 Pages: 12223-12232
- DOI
  10.1074/jbc.m116.719815
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H00878, KAKENHI-PROJECT-15H04363, KAKENHI-PROJECT-25250002, KAKENHI-PLANNED-25104004, KAKENHI-PROJECT-16H04776, KAKENHI-PROJECT-26460044, KAKENHI-PROJECT-15K12769, KAKENHI-PROJECT-15K18519
[Journal Article] Converting a light-driven proton pump into a light-gated proton channel2015
- Author(s)
  K. Inoue, T. Tsukamoto, K. Shimono, Y. Suzuki, S. Miyauchi, S. Hayashi, H. Kandori, Y. Sudo*
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Issue: 9 Pages: 3291-3299
- DOI
  10.1021/ja511788f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247024, KAKENHI-PROJECT-23687019, KAKENHI-PLANNED-25104004, KAKENHI-PLANNED-25104009, KAKENHI-PROJECT-25291034, KAKENHI-PUBLICLY-26115706, KAKENHI-PROJECT-26460044, KAKENHI-PROJECT-26620005, KAKENHI-PROJECT-26708001
[Journal Article] Structural basis for the slow photocycle and late proton release in Acetabularia rhodopsin I from the marine plant Acetabularia acetabulum2015
- Author(s)
  Furuse M, Tamogami J, Hosaka T, Kikukawa T, Shinya N, Hato M, Ohsawa N, Kim SY, Jung KH, Demura M, Miyauchi S, Kamo N, Shimono K,Kimura-Someya T, Yokoyama S, Shirouzu M
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr
  
  Volume: 71 Issue: 11 Pages: 2203-2216
- DOI
  10.1107/s1399004715015722
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460044
[Journal Article] Electrophysiological characterization of human Na+/taurocholate cotransporting polypeptide (hNTCP) heterologously expressed in Xenopus laevis oocytes2014
- Author(s)
  Masuda M, Ichikawa Y, Shimono K, Shimizu M, Tanaka Y, Nara T, Miyauchi S
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 562 Pages: 115-121
- DOI
  10.1016/j.abb.2014.08.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460044
[Journal Article] Thermodynamic parameters of anion binding to halorhodopsin from Natronomonas pharaonis by isothermal titration calorimetry2013
- Author(s)
  Hayashi, Saori
- Journal Title
  
  Biophysical Chemistry
  
  Volume: 172 Pages: 61-67
- DOI
  10.1016/j.bpc.2013.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23657096, KAKENHI-PROJECT-23790060
[Journal Article] A study of the interaction of drugs with liposomes with isothermal titration calorimetry2013
- Author(s)
  Osanai H, Ikehara T, Miyauchi S1, Shimono K, Tamogami J, Nara T, Kamo N
- Journal Title
  
  Journal of Biophysical Chemistry
  
  Volume: 4 Issue: 01 Pages: 11-21
- DOI
  10.4236/jbpc.2013.41002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23790060
[Journal Article] Thermodynamic parameters of anion binding to halorhodopsin from Natronomonas pharaonis by isothermal titration calorimetry2013
- Author(s)
  Hayashi, S., Tamogami, J., Kikukawa, T., Okamoto, H., Shimono, K., Miyauchi, S., Demura, M., Nara, T., and Kamo, N.
- Journal Title
  
  Biophys Chem
  
  Volume: 172 Pages: 61-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062
[Journal Article] A study of the interaction of drugs with liposomes with isothermal titration calorimetry2013
- Author(s)
  Osanai H., Ikehara T., Miyauchi S., Shimono K., Tamogami J., Nara T., Kamo N.
- Journal Title
  
  J Biophys Chem
  
  Volume: 4 Pages: 11-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062
[Journal Article] Expression of salinarum halorhodopsin in Escherichia coli cells : solubilization in the presence of retinal yields the natural state2011
- Author(s)
  Yamashita, Y., Kikukawa, T., Tsukamoto, T., Kamiya, M., Aizawa, T., Kawano, K., Miyauchi, S., Kamo, N., and Demura, M.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1808 Pages: 2905-2912
- NAID
  120003762628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062
[Journal Article] Expression of salinarum halorhodopsin in Escherichia coli cells : Solubilization in the presence of retinal yields the natural state2011
- Author(s)
  Yamashita Yasutaka
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranes
  
  Volume: 1808 Issue: 12 Pages: 2905-2912
- DOI
  10.1016/j.bbamem.2011.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23657096
[Journal Article] Photochemistry of acetabularia rhodopsin II from a marine plant, Aceta bularia acetabulum2011
- Author(s)
  Kikukawa Takashi
- Journal Title
  
  Biochemistry
  
  Volume: 50 Issue: 41 Pages: 8888-8898
- DOI
  10.1021/bi2009932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23790060
[Journal Article] Photochemistry of Acetabularia rhodopsin II from a marine plant, Acetabularia acetabulum2011
- Author(s)
  Kikukawa, T., Shimono, K., Tamogami, J., Miyauchi, S., Kim, S. Y., Kimura- Someya, T., Shirouzu, M., Jung, K. H., Yokoyama, S., and Kamo, N.
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 8888-8898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062
[Journal Article] Crystal structure of the Eukaryotic light-driven proton-pumping rhodopsin, Acetabularia rhodopsin II from Marine Algae2011
- Author(s)
  Wada Takashi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 411 Issue: 5 Pages: 986-998
- DOI
  10.1016/j.jmb.2011.06.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23790060
[Journal Article] Crystal structure of the eukaryotic light-driven proton-pumping rhodopsin, Acetabularia rhodopsin II, from marine alga2011
- Author(s)
  Wada, T., Shimono, K., Kikukawa, T., Hato, M., Shinya, N., Kim, S. Y., Kimura-Someya, T., Shirouzu, M., Tamogami, J., Miyauchi, S., Jung, K. H., Kamo, N., and Yokoyama, S.
- Journal Title
  
  J Mol Biol
  
  Volume: 411 Pages: 986-998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062
[Journal Article] Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.2010
- Author(s)
  Miyauchi S., Gopal E., Babu E., Srinivas S.R., Kubo Y., Umapathy N. S., Thakkar S.V., Ganapathy V., Prasad P.D.
- Journal Title
  
  Biochim Biophys Acta 1798
  
  Pages: 1164-1171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Sodium-coupled electrogenic transport of pyroglutamate 5-oxoproline via SLC5A8, a monocarboxylate transporter.2010
- Author(s)
  Seiji Miyauchi
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1798 Pages: 1164-1171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes.2010
- Author(s)
  Yamamoto T., Sugawara M., Kikukawa T., Miyauchi, S., Yamaguchi M., Tero A., Takagi S., Nakagaki T.
- Journal Title
  
  Biophysical Chemistry 147
  
  Pages: 59-65
- NAID
  120001971708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Role of Arg123 in light-driven anion pump mechanisms of pharaonis halorhodopsin2009
- Author(s)
  Megumi Kubo, Takashi Kikukawa, Seiji Miyauchi, Akiteru Seki, Masakatsu Kamiya, Tomoyasu Aizawa, Keiichi Kawano, Naoki Kamo, Makoto Demura
- Journal Title
  
  Photochem. Photobiol. 85
  
  Pages: 547-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19614001
[Journal Article] A tin oxide transparent electrode provides the means for rapid time-resolved pH measurements: Application to photoinduced proton transfer of bacteriorhodopsin and proteorhodopsin2009
- Author(s)
  J. Tamogami, T. Kikukawa, S. Miyauchi, E. Muneyuki, N. Kamo
- Journal Title
  
  Photochem. Photobiol. 85
  
  Pages: 578-589
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Role of Arg123 in light-driven anion pump mechanism of pharaonis halorhodopsin.2009
- Author(s)
  M. Kubo, T. Kikukawa, S. Miyauchi, A. Seki, M. Kamiya, T. Aizawa, K. Kawano, N. Kamo, M. Demura
- Journal Title
  
  Photochem. Photobiol. 85
  
  Pages: 547-555
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] A tin oxide transparent electrode provides the means for rapid time-resolved pH measurements : application to photoinduced proton transfer of bacteriorhodopsin and proteorhodopsin.2009
- Author(s)
  Tamogami J., Kikukawa T., Miyauchi S., Muneyuki E., Kamo N.
- Journal Title
  
  Photochem Photobiol 85
  
  Pages: 578-589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Production of functional bacteriorhodopsin by an Escherichia coli cell-free protein synthesis system supplemented with steroid detergent and lipid2009
- Author(s)
  K. Shimono, M. Goto, T. Kikukawa, S. Miyauchi, M. Shirouzu, N. Kamo, S. Yokoyama
- Journal Title
  
  Protein Sci. 18
  
  Pages: 2160-2171
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Role of Arg123 in light-driven anion pump mechanisms of pharaonis halorhodopsin.2009
- Author(s)
  Kubo M., Kikukawa T., Miyauchi S., Seki A., Kamiya M., Aizawa T., Kawano K., Kamo N., Demura M.
- Journal Title
  
  Photochem Photobiol 85
  
  Pages: 547-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Uptake of 3,4-methylenedioxy- methamphetamine and its related compounds by a proton-coupled transport system in Caco-2 cells.2008
- Author(s)
  Kuwayama K., Inoue H., Kanamori T., Tsujikawa K., Miyaguchi H., Iwata Y., Miyauchi S., Kamo N., Kishi T.
- Journal Title
  
  Biochim Biophys Acta 1778(1)
  
  Pages: 42-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Mechanism of ion transport via azide-bound halorhodopsin from Natronomonas pharaonis2008
- Author(s)
  S. Miyauchi, 他6名
- Journal Title
  
  Yakugaku Zasshi-J. Pharmaceut. Soc. Japan 128
  
  Pages: 133-134
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Stimulation of Na^+/Cl^--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2.2008
- Author(s)
  Thakkar S.V., Miyauchi S., Prasad P.D., Ganapathy V.
- Journal Title
  
  Drug Metab Pharmacokinet 23
  
  Pages: 254-262
- NAID
  10021956289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by aproton-coupled transport system in Caco-2 cells2008
- Author(s)
  Kuwayama K, Inoue H, Kanamori T, Tsujikawa K, Miyaguchi H, Iwata Y, Miyauchi S, Kamo N and KishiT
- Journal Title
  
  Biochim Biophys Acta 1778
  
  Pages: 42-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Studies on effects of external electric fields on halobacteria with fluorescence intensity and fluorescence lifetime imaging microscopy.2008
- Author(s)
  Nakabayashi T., Wang H.P. Tsujimoto K., Miyauchi S., Kamo N., Ohta N.
- Journal Title
  
  Chemistry Letters 37(5)
  
  Pages: 522-523
- NAID
  10021080359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590031
[Journal Article] Interaction of the halobacterial transducer to a halorhodopsin mutant engineered so as to bind the transducer: Cl-circulationwithin the extracellular channel2007
- Author(s)
  Hasegawa C, Kikukawa T, Miyauchi S, Seki A, Sudo Y, Kubo M, Demura M and KamoN
- Journal Title
  
  Photochem Photobiol 83
  
  Pages: 293-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Transport of nicotinate and structurally related compounds by human SMCT1(SLC5A8)and its relevance to drug transport in the mammalian intestinal tract2007
- Author(s)
  Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB and Ganapathy V
- Journal Title
  
  Pharm Res 24
  
  Pages: 575-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Heterologous expression of pharaonis halorhodopsin in Xenopus laevis oocytes and electrophysiological characterization of its light-driven Cl-pump activity.2007
- Author(s)
  Seki, A., S.Miyauchi, S.Hayashi, T.Kikukawa, M.Kubo, M.Demura, V.Ganapathy, N.Kamo
- Journal Title
  
  Biophys J. PMID : 17208978
- NAID
  120000965285
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Anti-parallel membrane topology of two components of EbrAB, a multidrug transporter2007
- Author(s)
  T. Kikukawa, S. Miyauchi, T. Araiso, N. Kamo, T. Nara
- Journal Title
  
  Biochem. Biophys. Res. Commun. 358
  
  Pages: 1071-1075
- NAID
  120000967947
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Differential modulation of sodium- and chloride-dependent opioidpeptide transport system by small nonopioid peptides and freeaminoacids2007
- Author(s)
  Miyauchi S, Gopal E, Thakkar SV, Ichikawa S, Prasad PD and Ganapathy V
- Journal Title
  
  J Pharmacol Exp Ther 321
  
  Pages: 257-264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Difference between pharmacokinetics of mycophenolic acid(MPA) in rats and that in humans is caused by different affinities of MRP2 to aglucuronized form2007
- Author(s)
  Takekuma Y, Kakiuchi H, Yamazaki K, Miyauchi S, Kikukawa T, Kamo N, Ganapathy V and Sugawara M
- Journal Title
  
  J Pharm Pharm Sci 10
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Anti-parallel membrane topology of two components of EbrAB, amultidrug transporter2007
- Author(s)
  Kikukawa T, Miyauchi S, Araiso T, Kamo N and Nara T
- Journal Title
  
  Biochem Biophys Res Commun 358
  
  Pages: 1071-1075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Heterologous expression of pharaonis halorhodopsin in Xenopus laevis oocytes and electrophysiological characterization of its light-driven Cl^-pump activity2007
- Author(s)
  Akiteru Seki, Seiji Miyauchi, Saori Hayashi, Takashi Kikukawa, Megumi Kubo, Makoto Demura, Vadivel Ganapathy, Naoki Kamo
- Journal Title
  
  Biophys. J. 92
  
  Pages: 2559-2569
- NAID
  120000965285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19614001
[Journal Article] Interaction of the halobacterial transducer to a halorhodopsin mutant engineered so as to bind the transducer: Cl-circulation within the extracellular channel.2007
- Author(s)
  C. Hasegawa, T. Kikukawa, S. Miyauchi, A. Seki, Y. Sudo, M. Kubo, M. Demura, N. Kamo
- Journal Title
  
  Photochem. Photobiol. 83
  
  Pages: 293-302
- NAID
  120000952618
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Differential modulation of sodium-and chloride-dependent opioid peptide transport system by small nonopioid peptides and freeamino acids.2007
- Author(s)
  Seiji Miyauchi
- Journal Title
  
  J Pharmacol Exp Ther 321
  
  Pages: 257-264
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines2007
- Author(s)
  Gopal E, Miyauchi S, Martin PM, Ananth S, Srinivas SR, Smith SB, Prasad PD and Ganapathy V
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids.2007
- Author(s)
  Seiji Miyauchi.
- Journal Title
  
  J Pharmacol Exp Ther 321(1)
  
  Pages: 257-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Heterologous expression of pharaonis halorhodopsin in Xenopus laevis oocyte and electrophysiological characterization of its light-driven Cl-pump activity2007
- Author(s)
  A. Seki, S. Miyauchi, S. Hayashi, T. Kikukawa, M. Kubo, M. Demura, V. Ganapathy, N. Kamo
- Journal Title
  
  Biophys. J. 92
  
  Pages: 2559-2569
- NAID
  120000965285
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Interaction of the Halobacterial Transducer to a Halorhodopsin Mutant Engineered so as to Bind the Transducer : Cl^- Circulation within the Extracellular Channel2007
- Author(s)
  Chisa Hasegawa, Takashi Kikukawa, Seiji Miyauchi, Akiteru Seki, Yuki Sudo, Megumi Kubo, Makoto Demura, Naoki Kamo
- Journal Title
  
  Photochem. Photobiol. 83
  
  Pages: 293-302
- NAID
  120000952618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19614001
[Journal Article] Anti-parallel Membrane Topology of a Homo-dimeric Multidrug Transporter, EmrE2007
- Author(s)
  Nara T, Kouyama T, Kurata Y, Kikukawa T, Miyauchi S and Kamo N
- Journal Title
  
  J Biochem(Tokyo) 142
  
  Pages: 621-625
- NAID
  10020095644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Anti-parallel membrane topology of a homo-dimeric multidrug transporter, EmrE.2007
- Author(s)
  T. Nara, T. Kouyama, Y. Kurata, T. Kikukawa, S. Miyauchi, N. Kamo
- Journal Title
  
  J. Biochem. 142
  
  Pages: 621-625
- NAID
  10020095644
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Interactions between 3,4-methylenedioxymethamphetamine, methamphetamine, ketamine, and caffeine in human intestinal Caco-2 cells and in oral administration to rats2007
- Author(s)
  Kuwayama K, Inoue H, Kanamori T, Tsujikawa K, Miyaguchi H, Iwata Y, Miyauchi S, Kamo N and KishiT
- Journal Title
  
  Forensic Sci Int 170
  
  Pages: 183-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] The Extracellular pH Dependency of Transport Activity by Human Oligopeptide Transporter 1 (hPEPT1) Expressed Stably in Chinese Hamster Ovary (CHO) Cells : A Reason for the Bell-Shaped Activity versus pH.,2006
- Author(s)
  Fujisawa, Y., R.Tateoka, T.Nara, N.Kamo, T.Taira, S.Miyauchi
- Journal Title
  
  Biol Pharm Bull 29
  
  Pages: 997-1005
- NAID
  110005602229
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Functional Characteristics of NaS2, a Placenta-specific Na(+)-coupled Transporter for Sulfate and Oxyanions of the Micronutrients Selenium and Chromium.2006
- Author(s)
  Miyauchi, S., S.R.Srinivas, Y.J.Fei, E.Gopal, N.S.Umapathy, H.Wang, S.J.Conway, V.Ganapathy, P.D.Prasad
- Journal Title
  
  Placenta 27
  
  Pages: 550-559
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Measurement of electric current evoked by substrate transport via bi-directional H+/oligopeptide transporter over-expressed in HeLa cells : electrogenic efflux and existence of a newly observed channel-like state.2006
- Author(s)
  Fujisawa, Y., T.Kitagawa, M.Miyake, T.Nara, N.Kamo, S.Miyauchi
- Journal Title
  
  Arch Biochem Biophys. 445
  
  Pages: 166-173
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Interaction of Ibuprofen and Other Structurally Related NSAIDs with the Sodium-Coupled Monocarboxylate Transporter SMCT1 (SLC5A8).2006
- Author(s)
  Itagaki, S., E.Gopal, L.Zhuang, Y.J.Fei, S.Miyauchi, P.D.Prasad, V.Ganapathy
- Journal Title
  
  Pharm Res. 23
  
  Pages: 1209-1216
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Two-component bacterial multidrug transporter, EbrAB : Mutations making each component solely functional.2006
- Author(s)
  Kikukawa, T., T.Nara, T.Araiso, S.Miyauchi, N.Kamo
- Journal Title
  
  Biochim Biophys Acta. 1758
  
  Pages: 673-679
- NAID
  120000963464
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Functional Characteristics of NaS2, a Placenta-specific Na(+)-coupled Transporter for Sulfate and Oxyanions of the Micronutrients Selenium and Chromium.2006
- Author(s)
  Seiji Miyauchi
- Journal Title
  
  Placenta 27
  
  Pages: 550-559
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Functional Characteristics of NaS2, a Placenta-specific Na(+)-coupled Transporter for Sulfate and Oxyanions of the Micronutrients Selenium and Chromium.2006
- Author(s)
  Seiji Miyauchi.
- Journal Title
  
  Placenta 27(6-7)
  
  Pages: 550-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Journal Article] Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer2006
- Author(s)
  Gupta, N., P.M.Martin, S.Miyauchi, S.Ananth, A.V.Herdman, R.G.Martindale, R.Podolsky, V.Ganapathy
- Journal Title
  
  Biochem Biophys Res Commun. 343
  
  Pages: 571-577
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] フルオレッセイン誘導体を用いたヒト肺上皮細胞に機能発現するブロードな質認識性を示すH+/モノカルボン酸共輸送担体の機能同定2024
- Author(s)
  佐々木将太郎、宮内正二
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] ヒト気管肢上皮細胞(BEASE-2B)に機能発現するH+/モノカルボン酸共輸送担体2023
- Author(s)
  難部仁美、野口歩美、若月萌、渡邊昂太郎、早川北斗、佐々木将太郎、宮内正二
- Organizer
  第38回日本薬剤学会
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] 腎尿細管におけるトランスポーター(URAT)と他のトランスポーターとの機能連関2023
- Author(s)
  府川和樹、杉尾和昭、増田雅行、佐々木将太郎、宮内正二
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] フルオレセイン誘導体を用いたA549細胞における有機アニオン輸送の解析2023
- Author(s)
  佐々木将太郎、宮内正二
- Organizer
  第38回日本薬剤学会
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] 尿酸輸送担体の機能に関与する有機アニオン・カップリング2023
- Author(s)
  府川和樹、杉尾和昭、増田雅行、安西尚彦、佐々木将太郎、宮内正二
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] 筋毒性を惹起するモノカルボン酸薬物の骨格筋細胞への濃縮機構2023
- Author(s)
  吉田かりん、竹中紗織、佐々木将太郎、宮内正二
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] 様々な有機アニオンとの相互作用を有する輸送担体SMCT1 (SLC5A8)2023
- Author(s)
  杉尾和昭、府川和樹、増田雅行、佐々木将太郎、宮内正二
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] D体-アミノ酸の腎尿細管再吸収に関わる新たな輸送担体2022
- Author(s)
  杉尾和昭、府川和樹、増田雅行、佐々木将太郎、下野和実、宮内正二
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] Fluorescein を用いた腎尿細管再吸収に関与するモノカルボン酸輸送担体の機能評価2022
- Author(s)
  佐々木将太郎、滝口貴晴、杉尾和昭、増田雅行、宮内正二
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] Na+/モノカルボン酸共輸送担体を介したアミノ酸輸送2021
- Author(s)
  杉尾和昭、府川和樹、増田雅行、佐々木将太郎、下野和実、宮内正二
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] オリゴペプチド輸送担体PEPT1のH+チャネル様機能変換に関わる構造的特徴2021
- Author(s)
  佐々木将太郎、石川龍、下野和実、宮内正二
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06519
[Presentation] ヒト肝癌由来HepG2細胞におけるNa+/オリゴペプチド共輸送担体の機能解析2020
- Author(s)
  増田雅行、小林朱音、國貞直人、佐々木将太郎、宮内正二
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] Na+/モノカルボン酸共輸送担体 (SLC5A8, SMCT1) の新たな基質認識機構および生理的意義の解明2020
- Author(s)
  杉尾和昭、府川和樹、増田雅行、佐々木将太郎、下野和実、宮内正二
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 『蛍光基質を用いたA549細胞における有機アニオン輸送の解析』2020
- Author(s)
  佐々木将太郎、宮内正二
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 尿細管上皮細胞に局在する輸送担体の機能解析：ブタ腎刷子縁膜ベシクルを用いた検討2020
- Author(s)
  大竹彩奈、伊藤遥、土井真奈美、杉尾和昭、増田雅行、佐々木将太郎、宮内正二
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 腎再吸収に関与する新規pH依存性輸送担体を介した腎障害性有機アニオン化合物の輸送2020
- Author(s)
  滝口貴晴、増田雅行、杉尾和昭、佐々木将太郎、宮内正二
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] ヒト肺上皮細胞における蛍光物質を輸送するpH依存性有機アニオン輸送担体の機能同定2020
- Author(s)
  難部仁美、若月萌、野口歩美、杉尾和昭、増田雅行、佐々木将太郎、宮内正二
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] ヒト腎尿細管由来細胞におけるモノカルボン酸輸送担体を介したフルオレセイン取り込み2020
- Author(s)
  佐々木将太郎1、杉尾和昭1,2、増田雅行、宮内正二
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 腎再吸収に関与する新規pH依存性輸送担体を介した腎障害性有機アニオン化合物の輸送2020
- Author(s)
  滝口貴晴、佐々木将太郎、宮内正二
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] Na+依存性胆汁酸輸送担体（NTCP）を介したtaurocholate efflux過程に対する基質依存性-対向輸送促進効果2020
- Author(s)
  田中丈希也，中島隼矢，小野和，増田雅行，杉尾和昭，佐々木将太郎，宮内正二
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 熱力学的解析手法を用いた大腸菌H+/オリゴペプチドトランスポーター(YdgR)の有する多様な基質認識機構の解明2020
- Author(s)
  大森明子、佐々木将太郎、下野和実、宮内正二
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 濃縮型核酸輸送担体 (CNT3, SLC28A3) による多彩な基質認識機構2020
- Author(s)
  宮内正二、増田雅行、杉尾和昭、佐々木将太郎、下野和実
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] Na+依存性胆汁酸輸送担体（NTCP）を介したtaurocholate efflux過程における対向輸送促進効果2019
- Author(s)
  田中丈希也、中島隼矢、小野和、増田雅行、佐々木将太郎、宮内正二
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 腎尿細管におけるpH依存性モノカルボン酸輸送担体を介した腎毒性物質の再吸収機構2019
- Author(s)
  佐々木将太郎、杉尾和昭、増田雅行、宮内正二
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] ヒト気道上皮由来細胞株における Na+ 依存性 rhodamine 123 輸送の解析2019
- Author(s)
  佐々木将太郎、増田雅行、杉尾和昭、宮内正二
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 熱力学的解析手法を用いた大腸菌H+/オリゴペプチドトランスポーター(YdgR)の有する多様な基質認識機構の解明2019
- Author(s)
  大森明子、佐々木将太郎、下野和実、宮内正二
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 尿酸輸送担体とNa+/モノカルボン酸共輸送担体とのアニオンカップリング機構の解明2019
- Author(s)
  府川和樹、杉尾和昭、増田雅行、安西尚彦、佐々木将太郎、宮内正二
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 大腸菌多剤排出トランスポーターEmrEの基質結合における水分子の役割2019
- Author(s)
  下野和実、宮本秀一、宮内正二
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 濃縮型核酸輸送担体(CNT3, SLC28A3)の基質認識機構の解明2019
- Author(s)
  5.増田雅行、府川和樹、杉尾和昭、、佐々木将太郎、下野和実、宮内正二
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 熱力学的解析手法を用いた H+ / オリゴペプチドトランスポーター YdgR の多様な基質認識に起因する相互作用の検討2019
- Author(s)
  大森明子、浅倉祐未、佐々木将太郎、下野和実、宮内正二
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] Human concentrative nucleoside transporter 3 (hCNT3, SLC28A3) has versatile ability to transport nucleoside analogues, aciclovir and ganciclovir2019
- Author(s)
  Masayuki Masuda, Kazuaki Sugio, Shotaro Sasaki, Kazumi Shimono, Ryoji Konishi, Ikuko Tsukamoto, Seiji Miyauchi
- Organizer
  The American Association of Pharmaceutical Scientists (AAPS) Annual Meeting (2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] SMCT1の多彩な基質認識機構と腎再吸収機構における役割2019
- Author(s)
  杉尾和昭、府川和樹、増田雅行、佐々木将太郎、下野和実、宮内正二
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] H+/オリゴペプチド共輸送担体 PEPT1 の多彩な基質認識機構2019
- Author(s)
  菅野美生、日改祐太、増田雅行、杉尾和昭、佐々木将太郎、下野和実、宮内正二
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 濃縮型核酸輸送担体(CNT3, SLC28A3)の基質認識機構の解明2019
- Author(s)
  増田雅行、杉尾和昭、佐々木将太郎、下野和実、宮内正二
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] ニコチン酸によるオリゴペプチド輸送担体 PEPT1 の機能調節2019
- Author(s)
  佐々木将太郎、菅野美生、日改祐太、石川龍、杉尾和昭、増田雅行、下野和実、宮内正二
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 大腸における5-アミノサリチル酸とそのアミノ酸誘導体のトランスポーターを介した輸送特性の評価2019
- Author(s)
  由利龍嗣、河野裕允、宮内正二、寺田智祐、藤田卓也
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] Human concentrative nucleoside transporter 3 (hCNT3, SLC28A3) has versatile ability to transport nucleoside analogues, aciclovir and ganciclovir2019
- Author(s)
  Masayuki Masuda, Kazuaki Sugio, Shotaro Sasaki, Kazumi Shimono, Ryoji Konishi, Ikuko Tsukamoto, Seiji Miyauchi
- Organizer
  第34回日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 尿酸輸送担体とNa+/モノカルボン酸共輸送担体とのアニオンカップリング機構の解明2019
- Author(s)
  府川和樹、杉尾和昭、増田雅行、安西尚彦、佐々木将太郎、宮内正二
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 3.腎尿細管Na+/モノカルボン酸共輸送担体によるアミノ酸輸送分子機構の解明2018
- Author(s)
  杉尾和昭、猪田大誠、増田雅行、佐々木将太郎、下野和実、宮内正二
- Organizer
  第13回トランスポター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 熱力学的解析手法を用いたH＋/オリゴペプチドトランスポーター（YdgR）の多様な基質認識に起因する相互作用の検討2018
- Author(s)
  大森明子、佐々木将太郎、下野和実、宮内正二
- Organizer
  第13回トランスポター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] VEGF/NGF mimicな核酸アナログCOA-Clを認識、輸送する輸送担体の同定2018
- Author(s)
  宮内正二、増田雅行、杉尾和昭、佐々木将太郎、下野和実、榊原紀和、小西良士、塚本郁子
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 4.様々な有機アニオンによる胆汁酸の対向輸送促進効果2018
- Author(s)
  増田雅行，田中丈希也，中島隼矢，小野和，佐々木将太郎，宮内正二
- Organizer
  第３回トランスポター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] アニオン性医薬品fluoresceinの輸送に対するモノカルボン酸化合物の影響2018
- Author(s)
  佐々木将太郎、増田雅行、杉尾和昭、宮内正二
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 腎尿細管に機能発現するpH依存性有機アニオン輸送担体はフェノキシ酢酸系除草剤の再吸収に関与する2018
- Author(s)
  佐々木将太郎、杉尾和昭、増田雅行、宮内正二
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] 有機アニオン輸送担体の基質薬物とオリゴペプチド輸送担体 (PEPT1) との相互作用2018
- Author(s)
  佐々木将太郎、石川龍、大熊宏、杉尾和昭、増田雅行、下野和実、宮内正二
- Organizer
  第13回トランスポター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06608
[Presentation] Effect of albumin on the hepatic uptake/pharmacokinetics of highly bound drug2017
- Author(s)
  Seiji Miyauchi
- Organizer
  THE 9th SUGIYAMA LABORATORY (RIKEN) OPEN SYMPOSIUM
- Place of Presentation
  RIKEN Yokohama Main Building Hall (Yokohama, Kanagawa)
- Year and Date
  2017-02-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 血清アルブミン肝取り込み促進機構モデルの構築2016
- Author(s)
  花島絵里加、増田雅行、下野和実、杉山雄一、宮内正二
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場(岐阜県、岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Na+/モノカルボン酸共輸送担体（SMCT1）の多彩な基質輸送能力2016
- Author(s)
  杉尾和昭、猪田大誠、増田雅行、下野和実、真坂亙、宮内正二
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場(岐阜県、岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] アセタブラリアロドプシンIIのプロトン移動におけるD92およびC218残基間の相互作用の役割2016
- Author(s)
  田母神淳、菊川峰志、大川啓介、大沢登、伊達公平、奈良敏文、出村誠、染谷友美、白水美香子、横山茂之、宮内正二、下野和実、加茂直樹
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 多剤輸送担体EmrEの基質結合エントロピー利得に対する水分子の寄与2016
- Author(s)
  下野和実、松田佳祐、鈴木翔子、矢嶋香歩、山本祥世、染谷友美、白水美香子、横山茂之、宮内正二
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-09-27
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] ヒト肝癌由来HepG2細胞におけるNa+/オリゴペプチド共輸送担体の機能解析2016
- Author(s)
  小林朱音、國貞直人、下野和実、宮内正二
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場(岐阜県、岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Can "free drug theory" feasibly evaluate the hepatic uptake clearance of a drug with highly protein binding?2016
- Author(s)
  Seiji Miyauchi
- Organizer
  THE 7th SUGIYAMA LABORATORY (RIKEN) OPEN SYMPOSIUM
- Place of Presentation
  RIKEN Yokohama Main Building Hall (Yokohama, Kanagawa)
- Year and Date
  2016-02-16
- Invited
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 大腸菌 H + /オリゴペプチド共輸送担体（YdgR）における多選択的基質認識機構の熱力学的解析2016
- Author(s)
  大森明子、下野和実、宮内正二
- Organizer
  第11回トランスポーター研究会年会
- Place of Presentation
  京都大学・宇治キャンパスきはだホール（京都府、宇治市）
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Na+-coupled monocarboxylate transporter SMCT1 (SLC5A8) has versatile ability to transport cyclic amino acid derivates in the form of zwitterions2016
- Author(s)
  Seiji Miyauchi, Kazuaki Sugio, Masayuki Masuda, Kazumi Shimono, Vadivel Ganapathy
- Organizer
  2016 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  Colorado Convention Center (Denver, CO (USA))
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] ヒト Na+ /モノカルボン酸共輸送担体(SMCT1)の多彩な基質輸送能力2016
- Author(s)
  杉尾和昭、猪田大誠、鴇田翔平、増田雅行、下野和実、宮内正二
- Organizer
  第11回トランスポーター研究会年会
- Place of Presentation
  京都大学・宇治キャンパスきはだホール（京都府、宇治市）
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] サーモフィリックロドプシンの耐熱性・高光遺伝学活性の構造基盤2016
- Author(s)
  塚本卓、水谷健二、長谷川太祐、高橋めぐみ、本田尚也、橋本直記、下野和実、宮内正二、高木新、林重彦、村田武士、須藤雄気
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 熱力学的測定によるオリゴペプチド輸送担体（YdgR）の基質認識における多選択機構の解析2016
- Author(s)
  下野和実、大森明子、宮内正二
- Organizer
  第３8回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋市立大学大学院薬学研究科・図書館棟（愛知県、名古屋市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Na+モノカルボン酸輸送担体(SMCT)の有する多様な基質認識能力2015
- Author(s)
  杉尾和昭、猪田大誠、鴇田翔平、増田雅行、下野和実、宮内正二
- Organizer
  第３7回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学薬学部・研究総合棟（熊本県、熊本市）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 血清アルブミンの有機アニオンの肝取り込みに及ぼす影響2015
- Author(s)
  増田雅行、田中裕大、岩角祥子、下野和実、真坂亙、宮内正二
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 電気生理学的手法を用いた起電性薬物輸送担体の基質認識機構の解明2015
- Author(s)
  宮内正二
- Organizer
  第5回杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  理化学研究所横浜事業交流棟ホール　(神奈川県、横浜市）
- Year and Date
  2015-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] A novel hepatic transport model considering a significant ligand-transporter binding leading to a change in unbound fraction in the medium, which can feasibly explain the “albumin-mediated hepatic uptake” phonomenon2015
- Author(s)
  Seiji Miyauchi, Masayuki Masuda, Yuudai Tanaka, Shouko Iwakado, Kazumi Shimono, SooJin Kim, Yuichi Sugiyama
- Organizer
  30th Japanese Society for the Study of Xenobiotics Annual Meeting
- Place of Presentation
  Tower Hall Funabori (Edogawa, Tokyo)
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Na+/モノカルボン酸共輸送担体(SMCT)におけるブロードな基質認識機構の解明2015
- Author(s)
  猪田大誠、鴇田翔平、増田雅行、杉尾和昭、清水真紀、奈良敏文、下野和実、宮内正二
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸サンボーホール　(兵庫県、神戸市）
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Involvement of human Na+/taurocholate (TCA) cotransporting polypeptide (hNTCP) in the hepatic uptake of various statins2015
- Author(s)
  Masayuki Masuda, Kazuaki Sugio, Kazumi Shimono, Seiji Miyauchi
- Organizer
  2015 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  Orange County Convention Center (Orlando, FLA, USA)
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Na+/モノカルボン酸輸送担体におけるブロードな基質認識機構の解明2015
- Author(s)
  杉尾和昭、猪田大誠、増田雅行、下野和実、真坂　亙、宮内正二
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] アフリカツメガエル卵母細胞発現系を用いたヒト・ナトリウム依存性胆汁酸輸送担体(hNTCP)の機能解析2014
- Author(s)
  増田雅行,下野和実,真坂亙,宮内正二
- Organizer
  第134年会日本薬学会
- Place of Presentation
  日熊本市総合体育館,熊本
- Year and Date
  2014-03-30
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] 2,4-dichloro phenoxyacetate (2,4-D) の肝取り込み機構の解明2014
- Author(s)
  宮内正二、大野裕樹、下野和実
- Organizer
  第29回日本薬剤学会年会
- Place of Presentation
  大宮ソニックシティビル（埼玉県、さいたま市）
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Albumin mediated uptake of 1-anilino 8-naphthalene sulfonate (ANS) by primary cultured rat hepatocytes2014
- Author(s)
  Seiji Miyauchi, Yuudai Tanaka, Masayuki Masuda, Toshifumi Nara, Kazumi Shimono
- Organizer
  29th Japanese/19th International Society for the Study of Xenobiotics Joint Meeting
- Place of Presentation
  San Francisco Union Square Hilton (San Francisco, CA, USA)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 血清アルブミンによる蛍光試薬ANS肝取り込み促進機構の解明2014
- Author(s)
  田中裕大、増田雅行、岩角祥子、下野和実、奈良敏文、宮内正二
- Organizer
  第３６回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島大学藤井節郎記念ホール・大塚講堂 (徳島県、徳島市）
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] 血清アルブミンの蛍光試薬ANSの肝取り込み及ぼす影響2014
- Author(s)
  田中裕大、下野和実、宮内正二
- Organizer
  第29回日本薬剤学会年会
- Place of Presentation
  大宮ソニックシティビル（埼玉県、さいたま市）
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Involvement of a new pH-dependent transporter in the uptake of 2, 4-dichloro phenoxyacetate (2,4-D) by primary cultured rat hepatocytes2014
- Author(s)
  Seiji Miyauchi, Hiroki Ohno, Masayuki Masuda, Toshifumi Nara, Kazumi Shimono
- Organizer
  2014 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  San Diego Convention Center (San Diego, CA, USA)
- Year and Date
  2014-11-06
- Data Source
  KAKENHI-PROJECT-26460044
[Presentation] Acetabularia rhodopsin II (ARII)のAsp81変異体による一過性光誘起電流2014
- Author(s)
  宮内正二, 下野和実, 菊川峰志, 出村誠, Jung, K.H., 加茂直樹
- Organizer
  第５２回日本生物物理学会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26440042
[Presentation] Ser302 in Human Oligopeptide Transporter (hPEPT1) Regulates the Uptake Activity through a Hydrogen-bonding Interaction with the Crucial Residue, His572013
- Author(s)
  Miyauchi Seiji, Shimono Kazumi, Nara Toshifumi
- Organizer
  2013 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  Gonzalez Convention Center, San Antonio, USA
- Year and Date
  2013-11-13
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] The protonation state of a crucial residue, His57 in human oligopeptide transporter (hPEPT1) regulates the transport activity?2013
- Author(s)
  Miyauchi Seiji
- Organizer
  The Asian Federation for Pharmaceutical Sciences (AFPS) 2013
- Place of Presentation
  Ramada Plaza, Jeju, South Korea
- Year and Date
  2013-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Na^+ dependent opioid peptide transporter as a molecular target for drug development2013
- Author(s)
  Miyauchi Seiji
- Organizer
  The First International Conference of Sugiyama Laboratory : Drug Discovery, Development and Optimization of ADME Properties
- Place of Presentation
  Hibiya Convention Hall, Tokyo, Japan
- Year and Date
  2013-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] 無細胞タンパク質合成系を利用したヒト銅トランスポーター(hCtr1)の大量合成2012
- Author(s)
  下野和実,水谷賢人,横山茂之,宮内正二
- Organizer
  第7回トランスポーター研究会
- Place of Presentation
  日京都大学農学部(京都府)
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Human sodium-coupled monocarboxylate transporter (SMCT): Its physiological functions2012
- Author(s)
  Miyauchi, Seiji
- Organizer
  28^hAnnual Research Conference in Pharmaceutical Sciences
- Place of Presentation
  Chulalongkorn University, Bangkok, Thailand
- Year and Date
  2012-01-20
- Invited
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] ヒトオリゴペプチド輸送担体(hPEPT1)の活性中心であるHis57とSer302の相互作用2012
- Author(s)
  米田真一郎,宮内正二,佐々木将太朗,加茂直樹,下野和実
- Organizer
  日本薬剤学会,第27年会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Sodium-dependent monocarboxylate transporter2012
- Author(s)
  S. Miyauchi
- Organizer
  28thAnnual Research Conference in Pharmaceutical Sciences(招待講演)
- Place of Presentation
  Chulalongkorn University, Bangkok
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] H+/オリゴペプチド共輸送担体(hPEPT1)におけるHis57-Ser302水素結合による活性調節2011
- Author(s)
  佐々木将太郎，下野和実，藤澤祐紀，奈良敏文，加茂直樹，宮内正二
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  東北大学片平さくらホール（仙台）
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] H^+/オリゴペプチド共輸送担体(hPEPT1)におけるHis57-Ser302水素結合による活性調節2011
- Author(s)
  佐々木将太郎,下野和実,藤澤祐紀,奈良敏文,加茂直樹,宮内正二
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  東北大学片平さくらホール(仙台)
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] H^+/オリゴペプチド共輸送担体(hPEPT1)の活性中心His57近傍における水素結合とその役割2011
- Author(s)
  宮内正二,米田真一郎,佐々木将太郎,下野和実
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学創立五十周年記念館(岡山大学津島キャンパス,岡山市)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Characterization of human Na^+/taurocholate (TCA) cotransporting polypeptide (hNTCP) with an electrophysiological technique2011
- Author(s)
  Miyauchi Seiji, Shimono Kazumi, Nara Toshifumi, Kamo Naoki
- Organizer
  American Association of Pharmaceutical Scientists (AAPS) Annual Meeting
- Place of Presentation
  Walter E. Washington Convention Center (Washington DC)
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] H+/オリゴペプチド共輸送担体(hPEPT1)の活性中心His57近傍における水素結合とその役割2011
- Author(s)
  宮内正二，米田真一郎，佐々木将太郎，下野和実
- Organizer
  第３３回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学創立五十周年記念館（岡山大学津島キャンパス，岡山市）
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] 等温滴定型熱量計を用いた大腸菌由来 H+/オリゴペプチド共輸送担体（YdgR）の基質結合の熱力学的解析2011
- Author(s)
  下野和実，浅倉祐未，宮内正二
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  東北大学片平さくらホール（仙台）
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Characterization of human Na+/taurocholate (TCA) cotransporting polypeptide (hNTCP) with an2011
- Author(s)
  S. Miyauchi, K. Shimono, T. Nara, N. Kamo
- Organizer
  American Association of Pharmaceutical Scientists (AAPS) Annual Meeting
- Place of Presentation
  Walter E. Washington Convention Center (Washington DC)
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] 光駆動性クロライドポンプにおける基質認識機構の解明2010
- Author(s)
  宮内正二,下野和実,菊川峰志,出村誠,加茂直樹
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ,岡山
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] ハロロドプシンのCl-移動中における,シッフ塩基のpKaの変化2010
- Author(s)
  宮内正二,関顕照,下野和実,菊川峰志,出村誠,加茂直樹
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  東北大学川内北キャンパス,仙台
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] 光駆動性クロライドポンプにおける基質認識機構の解明2010
- Author(s)
  宮内正二
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山市
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] 光駆動性クロライドポンプにおける基質認識機構の解明2010
- Author(s)
  宮内正二
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] アザイド存在下における,光駆動性クロライドポンプのイオン輸送2010
- Author(s)
  宮内正二,関顕照,下野和実,菊川峰志,出村誠,加茂直樹
- Organizer
  第5回トランスポーター研究会
- Place of Presentation
  東京医科大学病院,東京
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] 光駆動性クロライドポンプにおける基質認識機構の解明2010
- Author(s)
  宮内正二
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ, 岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] ファラオニスハロロドプシンのCl^-輸送機構におけるAsp252の役割2009
- Author(s)
  菊川峰志,宮内正二,一尾裕章,北川拓,出村誠,加茂直樹
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  アスティ徳島,徳島
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] Na^+/モノカルボン酸共輸送担体(SMCT)の基質認識機構における構造活性相関2009
- Author(s)
  宮内正二
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] Role of the aspartic acid residue adjacent to the retinylidene Schiff base in the light-driven Cl- pump halorhodopsin.2009
- Author(s)
 Kikukawa T., Miyauchi S., Kitagawa Ichio H., T., Kamiya M., Aizawa T., Kawano K., Demura M., Kamo N
- Organizer
 15^<th> International Congress on Photobiology
- Place of Presentation
 Dusseldorf, Germany
- Year and Date
 2009-06-23
- Data Source
 KAKENHI-PROJECT-20590031
[Presentation] Can we deal with an opioid peptide transporter as a target for drug development?2009
- Author(s)
  宮内正二
- Organizer
  26th Annual Research Conference in Pharmaceutical Sciences
- Place of Presentation
  Chulalongkorn University, Bangkok
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] 光駆動クロライドイオンポンプ,ハロロドプシンのアザイド存在下におけるイオン輸送機構に関する研究2008
- Author(s)
  宮内正二,青山健太郎,菊川峰志,出村誠,Vadivel Ganapathy,加茂直樹
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌コンベンションセンター,札幌
- Year and Date
  2008-08-01
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] ハロロドプシンポンプ機能におけるシッフ塩基近傍酸性残基の役割2008
- Author(s)
  宮内正二
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場, 福岡
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] ハロロドプシンポンプ機能におけるシッフ塩基近傍酸性残基の役割2008
- Author(s)
  菊川峰志,宮内正二,関顕照,北川拓,出村誠,Vadivel Ganapathy,加茂直樹
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場,福岡
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] Transport of Neurotoxic monocarboxylate via the Na^+-Coupled Monocarboxylate Transporter SMCT1 (SLC5A8)2008
- Author(s)
  Seiji Miyauchi
- Organizer
  American Association of Pharmaceutic al Scientists (AAPS) Annual Meeting
- Place of Presentation
  Georgia World Congress Center, Atlanta
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] Transport of neurotoxic monocarboxylates via the Na^+-coupled monocarboxylate transporter SMCT1 (SLC5A8).2008
- Author(s)
  Miyauchi S., Dabazaki Y., Gopal E., Ganapathy V.
- Organizer
  American Association of Pharmaceutical Scientists (AAPS) Annual Meeting
- Place of Presentation
  Georgia World Congress Center, Atlanta
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] Role of Arg123 in light-driven anion pump mechanisms of N. pharaonis halorhodopsin, NpHR.2008
- Author(s)
  M. Kubo, T. Kikukawa, S. Miyauchi, M. Kamiya, T. Aizawa, K. Kawano, N. Kamo, M. Demura
- Organizer
  13th International Conference on Retinal Proteins
- Place of Presentation
  Barcelona, selected presentation
- Data Source
  KAKENHI-PROJECT-19390009
[Presentation] Vadivel Ganapathy and Naoki Kamo. Mechanism of proton transport via azide-bound halorhodopsin from Natronomonas pharaonis.2008
- Author(s)
  Seiji Miyauchi, Akiteru Seki , Takashi Kikukawa, Kentaro Aoyama, Makoto Demura
- Organizer
  第3回トランスポーター研究会
- Place of Presentation
  京都大学,京都
- Year and Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] Mechanism of proton transport via azide-bound halorhodopsin from Natronoraonas pharaonis2008
- Author(s)
  宮内正二
- Organizer
  第3回トランスポーター研究会
- Place of Presentation
  京都大学薬学部, 京都
- Year and Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] 光駆動クロライドイオンポンプハロロドプシンのアザイド存在下におけるイオン輸送機構に関する研究2008
- Author(s)
  宮内正二
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌コンベンシヲンセンター(札幌)
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] Important amino acid residues of functioning in Halorhodopsin from Natronomonas pharaonis, NpHR.2008
- Author(s)
  N. Kamo, S. Miyauchi, T. Kikukawa, H. Shigemura, Y. Saito, S. Hayashi, M. Kubo, T. Kitagawa, M. Demura
- Organizer
  13th International Conference on Retinal Proteins
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-19390009
[Presentation] Analysis of photo-induced proon uptake/release by bacteriorhodopsin and proteorhodopsin using a SnO2 transparent electrode2008
- Author(s)
  J. Tamogami, T. Kikukawa, S. Miyauchi, N. Kamo
- Organizer
  13th International Conference on Retinal Proteins
- Place of Presentation
  Barcelona. Invited Lecture
- Data Source
  KAKENHI-PROJECT-19390009
[Presentation] 光駆動性クロライドポンプ, ハロロドプシンのアザイド存在下におけるイオン輸送機構に関する研究2008
- Author(s)
  宮内正二
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌コンベンションセンター, 札幌
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-20590031
[Presentation] 光駆動クロライドイオンポンプハロロドプシンのアザイド存在下におけるイオン輸送機構に関する研究2008
- Author(s)
  宮内正二
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] Mechanism of proton transport via azide-bound halorhodopsin from Natronomonas pharaonis.2007
- Author(s)
 Seiji Miyauchi.
- Organizer
 45^<th> Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
 (Pacifico Yokohama)
- Year and Date
 2007-12-22
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] Natronomonas pharonis halorhodopsinのCl-輸送に関する研究:細胞質側でのCl-放出の解離定数の決定2007
- Author(s)
  重村洋明、菊川峰志、宮内正二、出村誠、加茂直樹
- Organizer
  第14回光生物協会年会
- Place of Presentation
  奈良先端科学技術大学院大学ミレニアムホール
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] Identification of a crucial residue involved in the translocation of Cl^- via a light-driven Cl^- pump.2007
- Author(s)
 Seiji Miyauchi.
- Organizer
 29^<th> Symposium on Biomembrane-Drug Interaction
- Place of Presentation
 (Sendai International Center)
- Year and Date
 2007-11-27
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] Identification of a crucial residue involved in the translocation of Cl-via a light-driven Cl pump2007
- Author(s)
  宮内正二
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台国際会議場
- Year and Date
  2007-11-26
- Data Source
  KAKENHI-PROJECT-19390009
[Presentation] アザイド存在下におけるハロロドプシンのプロトン輸送機構の解析2007
- Author(s)
  宮内正二
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2007-12-22
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] 光駆動性クロライドポンプによるCl-translocationに重要なアミノ酸残基の同定2007
- Author(s)
  宮内正二, 関顕照, 林沙織, 菊川峰志, 佐藤真紀, 出村誠, Vadivel Ganapathy, 加茂直樹
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] Identification of a crucial residue involved in the translocation of Cl^- via a light-driven Cl^- pump.2007
- Author(s)
 Seiji Miyauchi.
- Organizer
 2^<nd> Annual Meeting of the Japan Transporter Research Association
- Place of Presentation
 (Shouwa University, Tokyo)
- Year and Date
 2007-06-10
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] アザイド存在下におけるハロロドプシンのプロトン輸送機構の解析2007
- Author(s)
  宮内正二
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] 電気生理学的手法を用いた光駆動性クロライドポンプ輸送機構の解明2007
- Author(s)
  宮内正二
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山市総合体育館
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] 光駆動性クロライドポンプによるCl^-translocationに重要なアミノ酸残基の同定2007
- Author(s)
  宮内正二
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-11-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] Electrophysiological characterization of Its light-driven Cl^- pump.2007
- Author(s)
 Seiji Miyauchi.
- Organizer
 127^<th> Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
 (Toyama City Gymnasium)
- Year and Date
 2007-03-29
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] Identification of a crucial residue involved in the translocation of Cl- via a light-driven Cl- pump2007
- Author(s)
  Miyauchi, S.
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台国際センター(仙台市)
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] Halorhodopsin from Natronomonas Pharaonis (pHR) Is a Chloride Pump: Heterologous Expression of pHR in Xenopus Oocytes and Electrophysiological Characterization of Its Light-Driven Cl^- Pump2007
- Author(s)
  Seiji Miyauchi
- Organizer
  International Symposium" Nanocluster Chemistry and Life Science"
- Place of Presentation
  Hokkaido University
- Year and Date
  2007-01-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] SnO_2透明電極を用いた古細菌型ロドプシンの光誘起プロトン吸収・放出についての研究2007
- Author(s)
  田母神淳、阿部孝行、菊川峰志、宮内正二、加茂直樹
- Organizer
  第14回光生物協会年会
- Place of Presentation
  奈良先端科学技術大学院大学ミレニアムホール
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] Identification of a crucial residue involved in the translocation of Cl^- via a light-driven Cl^- pump2007
- Author(s)
  Seiji Miyauchi
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台市
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-19614001
[Presentation] 光駆動性クロライドポンプの基質translocationに重要なアミノ酸残基の同定2007
- Author(s)
  宮内正二
- Organizer
  第2回トランスポーター研究会
- Place of Presentation
  昭和大学,東京
- Year and Date
  2007-06-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] 輸送担体機能解析のparadigmとしての光駆動性クロライドポンプ2006
- Author(s)
  宮内正二
- Organizer
  第1回トランスポーター研究会
- Place of Presentation
  共立薬科大学,東京
- Year and Date
  2006-12-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] アフリカツメガエル卵母細胞発現系を用いた光駆動性クロライドポンプの電気生理学的機能解析2006
- Author(s)
  宮内正二
- Organizer
  第28回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  静岡県コンベンションアーツセンター,静岡
- Year and Date
  2006-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] Light-driven Cl^<1> pump as a paradigm for function studies on transport mechanism.2006
- Author(s)
 Seiji Miyauchi.
- Organizer
 1^<st> Annual Meeting of the Japan Transporter Research Association
- Place of Presentation
 Kyoritsu College of Pharmacy, Tokyo
- Year and Date
 2006-12-16
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] ヒトオリゴペプチド輸送担体の最も重要なアミノ酸残基His57の基質輸送活性pH依存性への関与2006
- Author(s)
  宮内正二
- Organizer
  第28回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  静岡県コンベンションアーツセンター,静岡
- Year and Date
  2006-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] ヒトNa^+/モノカルボン酸共輸送担体(hSMCT)の基質特異性2006
- Author(s)
  宮内正二
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  東京都江戸川区総合区民ホール
- Year and Date
  2006-11-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590028
[Presentation] Halorhodopsin from Natronomonas pharaonis (pHR) is a chloride pump: Heterologous expression of pHR in Xenopus oocytes and electrophysiological characterization of its light-driven Cl^- pump2006
- Author(s)
 Seiji Miyauchi
- Organizer
 28^<th> Symposium on Biomembrane-Drug Interaction
- Place of Presentation
 Shizuoka Convention & Arts Centrer "Granship", Shizuoka
- Year and Date
 2006-12-09
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] Essential molecular features of substrates via human sodium-coupled monocarboxylate transporter (hSMCT).2006
- Author(s)
 Seiji Miyauchi.
- Organizer
 21^<st> Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Place of Presentation
 Tower Hall Funabori, Tokyo
- Year and Date
 2006-12-29
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] The transport activity via human oligopeptide transporter (h-PEPT1) is regulated by the protonation/deprotonation state of the most crucial histidine, His572006
- Author(s)
 Seiji Miyauchi.
- Organizer
 28^<th> Symposium on Biomembrane-Drug Interaction
- Place of Presentation
 Shizuoka Convention & Arts Centrer "Granship", Shizuoka
- Year and Date
 2006-12-09
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18590028
[Presentation] アフリカツメガエル卵母細胞発現系を用いたヒト・ナトリウム依存性胆汁酸輸送担体(hNTCP)の機能解析
- Author(s)
  増田雅行，下野和実，真坂　亙，宮内正二
- Organizer
  第１３４年会日本薬学会
- Place of Presentation
  熊本市総合体育館，熊本
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] ヒトオリゴペプチド輸送担体(hPEPT1)の活性中心であるHis57 とSer302 の相互作用
- Author(s)
  米田真一郎，宮内正二，佐々木将太朗，加茂直樹，下野和実
- Organizer
  日本薬剤学会，第27年会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Na+ dependent opioid peptide transporter as a molecular target for drug development
- Author(s)
  Miyauchi Seiji
- Organizer
  The First International Conference of Sugiyama Laboratory: Drug Discovery, Development and Optimization of ADME Properties
- Place of Presentation
  Hibiya Convention Hall, Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] 無細胞タンパク質合成系を利用したヒト銅トランスポーター（hCtr1）の大量合成
- Author(s)
  下野和実，水谷賢人，横山茂之，宮内正二
- Organizer
  第7回トランスポーター研究会
- Place of Presentation
  京都大学農学部（京都府）
- Data Source
  KAKENHI-PROJECT-23590062
[Presentation] Ser302 in Human Oligopeptide Transporter (hPEPT1) Regulates the Uptake Activity through a Hydrogen-bonding Interaction with the Crucial Residue, His57
- Author(s)
  Miyauchi Seiji, Shimono Kazumi, Nara Toshifumi
- Organizer
  2013 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  Gonzalez Convention Center, San Antonio, USA
- Data Source
  KAKENHI-PROJECT-23590062

1. KAMO Naoki (10001976)

# of Collaborated Projects: 14 results

# of Collaborated Products: 10 results
2. KIKUKAWA Takashi (20281842)

# of Collaborated Projects: 14 results

# of Collaborated Products: 43 results
3. NARA Toshifumi (30241350)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
4. SUMI Masato (30281819)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. 原島秀吉 (00183567)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 篠原康雄 (60226157)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAMOGAMI Jun (30580089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHUTOH Satoru (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大熊芳明 (70192515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 丸山一雄 (30130040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 塚本卓 (30744271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 海野雅司 (50255428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATANABE Tohru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AZUMA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IKEDA Hisami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HIRAYAMA Junichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ABE Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 阿部秀樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 池淵研二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 安西尚彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 神取秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 須藤雄気

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 染谷友美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYAUCHI Seiji 宮内 正二

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Physiological significance of the albumin-facilitated transport: Clarification on the facilitated dissociation on the cell surfacePrincipal Investigator

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Elucidation of the molecular mechanism by the albumin-mediated hepatic uptake and new development of the mechanistic model to describe the albumin-mediated phenomenonPrincipal Investigator

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Elucidation of molecular mechanism by which a transporter with a potential to transport a variety of substrates is regulatedPrincipal Investigator

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Elucidation of the molecular valve in the transporter to determine the direction of the transporter cyclePrincipal Investigator

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Characterization of molecular mechanism of electrogenic transporters accompanying ion movementPrincipal Investigator

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A developmental approach to clarify a molecular mechanism of transporter utilizing a model transporter as a light-driven ion pumpPrincipal Investigator

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A new approach to investigate on electrogenic transporters with Xenopusoocyte expression systemPrincipal Investigator

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MIYAUCHI Seiji 宮内正二