NARA Toshifumi 奈良敏文

Researcher Number	30241350
Other IDs
Affiliation (Current)	2020: 松山大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2011 – 2012: 松山大学, 薬学部, 准教授 2009: 松山大学, 薬学部, 准教授 1998 – 2004: 北海道大学, 大学院・薬学研究科, 助手 2002: Hokkaido Univ., Grad. School of Pharm Sci., Assis. Prof., 薬学研究科, 助手 1999: 北大, 薬学研究科, 助手 1994 – 1997: Hokkaido University, Faculty of Pharmaceutical Sciences, Instructor, 薬学部, 助手 1993: 北海道大学, 薬学部, 教務職員
Review Section/Research Field	Principal Investigator Biophysics / Physical pharmacy Except Principal Investigator Physical pharmacy / Physical pharmacy / Biological Sciences / Biological pharmacy / Environmental pharmacy
Keywords	Principal Investigator 古細菌 / 高度好塩菌 / 大量発現 / 多剤耐性 / 大腸菌 / 多剤排出輸送担体 / PEPT1 / レチーナールタンパク / レチナ-ルタンパク質 / 分裂酵母 … More Except Principal Investigator Haloferax volcanii / 高度好塩菌 / Enterococcus hirae / ロ-ダミン123 / センソリーロドプシン / フォボロドプシン / レチナールタンパク / フォトサイクル / 微生物ロドプシン / 走光性 / バクテリオロドプシン / Natronobacterium pharaonis / P-糖タンパク / 多剤耐性 / Corynebacterium glutamicum / metabolic stress / リポソームカラム / リポソーム / ハロロドプシン / ホトサイクル / 等温滴定型熱量計 / ヒドロキシルアミン / 光化学中間体 / P-glycoprotein / ドキソルビシン / グルコース / 抗ガン剤 / Caco-2 / 多剤排出輸送体 / PEPT1 / ファラオニスフォボロドプシン / 吸収波長 / pharaonis phoborhodopsin / UVC / S / CFU / SVD / レチナール / archaeal rhodopsin / 薬物排出輸送体 / グルコース効果 / カタボライト抑制 / 多剤排出 / ATP駆動薬物排出ポンプ / 滴定型熱量計 / 吸着の熱力学量 / 疎水性相互作用 / tetraphenylphosphonium / tetraphenylboron / NMR / 溶離曲線の分散 / エンタルピー / エントロピー / 滴定型カロリメトリー / 脂溶性フォスフォニウムイオン / カラムクロマトグラフ / HPLC / 溶離プロファイル / 溶離曲線の広がり / lipophilic phosphonium cation / 脂溶性イオン / 膜ベジクル固定化 / 高速液体クロマトグラフィ / アビジン・ビオチン / 溶離パターン / 吸着速度定数 / 脱着速度定数 / サイトカイン / シグナル伝達 / STAT3 / 制御蛋白 / がん / オーサイト / 閃光光分解 / exciton-coupling / Circular Dichroism / C1輸送 / dodecy1-β-D-maltoside / MALDI-TOF / 解離定数 / Natronomonas Pharaonis / halorhodopsin / イオンポンプ / フラッシュフォトリシス / Clイオン結合 / Natronomonaa pharaonis / ハロロドプシン(halorhodopsin) / 3量体形成 / 卵母細胞 / C1イオン結合 / ホボロドプシン / ホトサイクルヒロロキシルアミン / レチナール異性化 / ブリーチ / カサノリ / ロドプシン / レチナールタンパク質 / Natronomonas pharaonis / Halobacterium salinarum / ラマンスペクトル / N中間体 / Haloarcular marismortui / フラクトース / Escherichia coli / 抗ガン剤排出タンパク / P-glycoprotein(Pgp) / Ca-拮抗剤 / フルクトース / プロベネシド / Multi-drug resistance / Anti-cancer reagents / Phodamine 123 / Fructose / Glucose / ペプチドトランスポータ / 蛍光生輸送基質 / メトキサレート / 蛍光性輸送基質 / ダイペプチド / FITC / Caco2 / Sw620 / ザルコシン / 腸管吸収 / 膜輸送 / リゾリン脂質 / 平面脂質二分子膜 / ピレン / フローレセッイン / Peptide transporter / fluorescent substrate / methoxylate / multi-efflux transporter / anti-cancer drugs / 高度好塩菌Haloferax volcanii / ABCスーパーファミリー / 腸内連鎖球菌Enterococcus hirae / 枯草菌Bacillus subtilis / エチジュウム / ヘキソキナーゼ / Thermus thermophilus / MDR(multi-drug resistance) / ABC transporter / ATP binding casette(ABC) / PCR / Halobacterium volcaii / EmrE / 大腸菌 / ABC super family / Enteroccus hirae / Bacillus subtilis / doxorubicin / ethidium / glucose / hexokinase / 発現系 / バクテリオバクテリオロドプシン / M中間体 / 光化学中間体の崩壊の速度 / シッフ塩基 / 発現系の構築 / プロトンの移動 / ph測定 / 大腸菌での発現系 / 分子動力学計算 / expression system / bacteriorhodosin / absorption wavelength / M-intermediate / the decay rate of photo-intermediate / schiff base / パルボウイルス / 紫外線照射 / ウイルスの熱処理 / D法 / ヘモグロビン / DNA障害 / ヒトパルボウイルスB19 / カテキン / メチレンブルー / 活性酸素 / ピリミジンダイマー / 6-4付加体 / 血液凝固第VIII因子 / 一重項酸素 / B19 / 血液凝固第8因子 / parvovirus / UV-irradiation / Heat treatment of virus / D treatment / Hemoglobin / DNA damage / ハロバクテリアルトランスジューサ / アーカエアルロドプシン / Archaeal rhodopsin / 波長制御 / バクテリオロドプシ / 固体NMR / 膜タンパク安定性 / Halobacterium halobium / 膜タンパク構造維持 / 呼吸波長 / photocycle / halobacterial transducer / flash photolysis / bacteriorhodopsin / color regulation / retinal protein / 透明電極 / トランスジューサ / ITC / FTIR / Natronomonas pharaconis / phoborhodopsin / HtrII / 古細菌ロドプシン / sensory rhodopsin / トランスジューサー / Natronomus pharaonis / Natronobacterium / Microbial rhodopson / Phoborhodopsn / Sensory rhodopson / Halobacteria / Retinal / Transparent electrode / Isothermal titration Calorimetry / Photo-taxis Less

photochemistry of sensory rhodopsin
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
  Matsuyama University
Elucidation of Cl--pumping mechanism and significance of trimer formation of halorhodopsin
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
サイトカインシグナル伝達系におけるSTAT3制御蛋白の役割
- Principal Investigator
  
  松田正
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Signal transduction via membrane protein complex : photo-signal transduction of Halobacterium salinarum
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
リポソームカラムによる脂質膜と薬物の相互作用の解析法の開発
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Biophysical Chemistry on photobrhodopsin, a sensor for a negative taxis of Halobacterium
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Application of a nutrient transporter for the drug delivery.Principal Investigator
- Principal Investigator
  
  NARA Toshifumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
脂溶性薬物の脂質2分子膜への吸着は「非古典的疎性水相互作用」か?
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Physical and/or Chemical Methods for the Removal of Virus from Transfusion Blood
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
大腸菌の多剤排出系EmrEの分子機構解明Principal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
PHYSICO-CHEMICAL STUDY ON PHARAONIS PHOBORHODOPSIN USING ITS RECOMBINANT PROTEIN
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
腸内連鎖球菌に存在するATP駆動型多剤排出輸送担体の機能解析Principal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
バクテリアにおけるATP駆動薬剤排出トランスポータに関する研究
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ファラオニスフォボロドプシン光サイクルの分子機構の解明:大量発現系の確立を通してPrincipal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
Physicochemical Studies on multi-drug Efflux Transporters of Bacteria
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
バクテリアにおけるATP駆動薬剤排出トランスポータに関する研究
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ファラオニスフォボロドプシン光サイクルの分子機構の解明:大量発現系の確立を通してPrincipal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
Drug Delivery System Utilizing Transporters That Recognize Substrates of Relatively Large Molecular Sizes
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Study on membrane transport of halobacterial cells used as model cells for the transport investigation of pharmaceutical agents
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University

All 2013 2012 2011 2010 2007

All Journal Article Presentation

[Journal Article] Thermodynamic parameters of anionbinding to halorhodopsin from Natronomonas pharaonis by isothermal titration calorimetry2013
- Author(s)
  Hayasi Saori, Tamogami Jun, Kikukawa Takashi, Okamoto Haruka, Shimono Kazumi, Miyauchi Seiji, Demura Makoto, Nara To shifumiKamo Naoki
- Journal Title
  
  Biophysical Chemistry
  
  Volume: 172巻 Pages: 61-6710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049
[Journal Article] The Photo-induced Proton Release in Proteorhodopsin at Low pH : The Possibility of the pKa Decrease of Asp2272013
- Author(s)
  Tamogami Jun, Kikukawa Takashi, NaraToshifumi , Shimono Kazumi, Demura Makoto, Kamo Naoki
- Journal Title
  
  Biochemistry
  
  Volume: 51巻 Pages: 9290-9301
- DOI
  10.1021/bi300940p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23657096, KAKENHI-PROJECT-23790060
[Journal Article] Photo-induced bleaching of sensory rhodopsin II (phoborhodopsin) from Halobaterium salinarum by hydroxylamine: Identification of the responsible intermediates.2012
- Author(s)
  Tamogami Jun, Kikukawa Takashi, IkedaYoichi, Demura Makoto, NaraToshifumi , KamoNaoki
- Journal Title
  
  Journal of Photochemistry and Photobiology B-Biology
  
  Volume: 106巻 Pages: 87-9410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049
[Journal Article] Anti-parallel membrane topology of two components of EbrAB, a multidrug transporter2007
- Author(s)
  T. Kikukawa, S. Miyauchi, T. Araiso, N. Kamo, T. Nara
- Journal Title
  
  Biochem. Biophys. Res. Commun. 358
  
  Pages: 1071-1075
- NAID
  120000967947
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Anti-parallel membrane topology of a homo-dimeric multidrug transporter, EmrE.2007
- Author(s)
  T. Nara, T. Kouyama, Y. Kurata, T. Kikukawa, S. Miyauchi, N. Kamo
- Journal Title
  
  J. Biochem. 142
  
  Pages: 621-625
- NAID
  10020095644
- Data Source
  KAKENHI-PROJECT-19390009
[Presentation] The role of chloride in the photo-induced proton transfer in sensory rhodopsin II from Natronomonas pharaoni2012
- Author(s)
  Tamogami, J., Iwano, K., Matsuyama, A., Kikukawa, T., Demura, M., Shimono, K., Nara, T. , Kamo , N
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学(名古屋市)
- Year and Date
  2012-09-23
- Data Source
  KAKENHI-PROJECT-22590049
[Presentation] 海洋細菌由来のロドプシン様タンパク質プロテオロドプシンの低pH条件下における速いプロトン放出機構2011
- Author(s)
  田母神淳、菊川峰志,下野和実,奈良敏文,宗行英朗,加茂直樹
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590049
[Presentation] Laser flash analysis of functional interaction between sensory rhodopsin NpSRII (ppR) and eubacterial chemoreceptor Tsr in E. coli2010
- Author(s)
  奈良敏文、菊川峰志、田母神淳、加茂直樹
- Organizer
  第48回日本生物物理学会
- Place of Presentation
  東北大学(仙台市)
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22590049
[Presentation] 負の走光性レセプターNpSRIIと大腸菌走化性レセプターTsrの機能的相互作用2010
- Author(s)
  奈良敏文
- Organizer
  日本生物物理学会
- Place of Presentation
  東北大学川内北キャンパス
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22590049

1. KAMO Naoki (10001976)

# of Collaborated Projects: 13 results

# of Collaborated Products: 8 results
2. MIYAUCHI Seiji (30202352)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
3. SUMI Masato (30281819)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. KIKUKAWA Takashi (20281842)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. SHUTOH Satoru (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MATUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松田正 (20212219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平敬宏 (70197036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Tohru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AZUMA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IKEDA Hisami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIRAYAMA Junichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ABE Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 阿部秀樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 池淵研二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAMOGAMI Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. SHIMONO Kazumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 出村誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NARA Toshifumi 奈良 敏文

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大腸菌の多剤排出系EmrEの分子機構解明Principal Investigator

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腸内連鎖球菌に存在するATP駆動型多剤排出輸送担体の機能解析Principal Investigator

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ファラオニスフォボロドプシン光サイクルの分子機構の解明:大量発現系の確立を通してPrincipal Investigator

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NARA Toshifumi 奈良敏文