Kitayama Hitoshi 北山仁志

… Alternative Names

KITAYAMA Hitoshi 北山仁志

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Researcher Number	30231286
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2012: 京都大学, 医学(系)研究科(研究院), 准教授 2010 – 2012: 京都大学, 医学研究科, 准教授 2009: 京都大学, 医学研究科, 助教授 2000 – 2004: 京都大学, 医学研究科, 助教授 2002: 京都大学, 医学研究科, 教授 … More 2001 – 2002: 京都大学, 大学院・医学研究科, 助教授 1999: 京都大学, 大学院・医学研究科, 助教授 1998: 京都大学, 医学研究科, 助手 1997: 京都大学, 大学院・医学研究科, 助手 1992 – 1994: 理化学研究所, ライフサイエンス筑波研究センター, 研究員 Less
Review Section/Research Field	Principal Investigator Tumor biology / Biological Sciences / Molecular biology Except Principal Investigator General medical chemistry / Biological Sciences / Neurology / Pathological medical chemistry
Keywords	Principal Investigator がん制御遺伝子 / エクソサイトーシス / 分泌 / アクチンストレスファイバー / GTPアーゼ / 細胞骨格 / two-hybrid法 / 遺伝子欠損マウス / 細胞質分裂 / グリア … More / シナプス小胞 / 神経細胞 / CDC10 / CDCrel-1 / 遺伝子欠陥マウス / Cdc42 / Borg / H5 / Nedd5 / セプチン / two-hybridアッセイ / two-hybrid アッセイ / Ras / Krev-1 … More Except Principal Investigator シグナル伝達 / MMP / c-IAP2 / TMX / septin / RECK / MT1-MMP / MMP-2 / Lewy body / H5 / Septin / TGF-β / signal transduction / 発生 / チオレドキシン / TGF-beta / エンハンサートラップ / エンハンサー・トラップ / Lewy小体 / パーキンソン病 / セプチン / endomucin / Ras / C3G / Rap1 / Glial cytoplasmic inclusion(GCI) / αsynuclein / Proteasome / Synphilin / 多系統萎縮症 / ubiquitin / α-synuclein / sepin / 黒質 / glial cytoplasmic inclusion(GCI) / glial cytoplasmic inclusion (GCI) / αシヌクレイン / プロテアゾーム / synphilin-1 / blood vessel / collagen / metastasis / invasion / cancer / Extracellular matrix / 転移抑制 / 軟骨 / VGEF / がん転移 / 血管新生 / RAS / 膵癌 / central core disease / 遺伝子欠損マウス / 筋肉 / 血管 / コラーゲン / 転移 / 浸潤 / 癌 / 細胞外マトリックス / X-ray-responsive genes / bleomycin / ER stress / thioredoxin / retroviral vector / 遺伝子発現 / Bax / NF-kB / X線 / レトロウイルスベクター / X線応答遺伝子 / ブレオマイシン / 小胞体ストレス / レトロウイスルベクター / contractile ring / myosin / actin / cytoskeleton / cell division / biomolecules / cell, tissue / PJ10 / 微小管 / Rho / 分裂シグナル / 分裂溝 / リン酸化 / アクチン調節タンパク質 / 低分子量Gタンパク質 / 細胞質分裂 / 細胞組織 / 収縮環 / ミオシン / アクチン / 細胞骨格 / 細胞分裂 / 生体分子 / 細胞・組織 / Pain-increased Krev-1 expression / Krev-1 expression / novel Ras function / erythropoietin receptor / small G protein / tumour suppressor gene / 増殖抑制遺伝子 / IL-2受容体 / Krev-1の痛み刺激による増強 / Krev-1蛋白の局在 / 新たなRas機能 / エリスロポエチン受容体 / 小分子量G蛋白質 / 癌抑制遺伝子 / 精子形成 / 甲状腺腫瘍 / N-Ras / Rb / 筋肉発生 / MRF / Sept4 / profilin II / Rg13 / CD13 / 軟骨分化 / 発現遺伝子プロファイリング / 条件的遺伝子欠損マウス / 酸素濃度 / 血清濃度 / 細胞密度 / 細胞移動 / fibronectin / 細胞マトリックス / Notch / ADAM / マウス遺伝学 / がん / PC12 / NGFI-A / RAP1 / ニューロトロフィン / 神経突起 / sindbis virus / RGL3 / グルタミン酸受容体 / 海馬 / シンドビズ・ウイルス / コロイドプレキサス / 遺伝性腫瘍 / ウイルムス腫瘍 / 網膜芽細胞腫 / 家族性大腸ポリポージス / 突然変異 / 発がん / ヘテロ接合性の消失 / がん抑制遺伝子 Less

Identification of the genes regulate Ras-mediated signalingby cDNA expression cloning methodPrincipal Investigator
- Principal Investigator
  
  KITAYAMA Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
Roles and Regulatory Mechanisms of Extracellular Matrix Remodeling in vivo
- Principal Investigator
  
  NODA Makoto
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Kyoto University
significance of septin in the formation of inclusion bodies in neurodegenerative disorders.
- Principal Investigator
  
  TOMIMOTO Hidekazu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Studies on the roles of the membrane-associated matrix metalloproteinase regulator BECK in angiogenesis
- Principal Investigator
  
  NODA Makoto
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KYOTO UNIVERSITY
神経突起伸長に関与する分子の探索と機能解析
- Principal Investigator
  
  野田亮
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Screening for signal-responsive genes by an enhancer-trap vector and their application
- Principal Investigator
  
  NODA Makoto
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  KYOTO UNIVERSITY
細胞形態制御における細胞質骨格蛋白セプチンの機能解析Principal Investigator
- Principal Investigator
  
  北山仁志, 木下専
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Mechanisms of formation and destruction of the contractile ring during cytokinesis
- Principal Investigator
  
  MABUCHI Issei
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
低分子量Gタンパク質Krev-1の機能解析Principal Investigator
- Principal Investigator
  
  北山仁志
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
がん抑制に関与する遺伝子群の研究
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Investigation of physiological function of the cell growth-regulating G-proteins and their signaling pathways.
- Principal Investigator
  
  IKAWA Yoji
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University

All 2012 2010 2009 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs2012
- Author(s)
  Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M
- Journal Title
  
  Biology Open
  
  Volume: (in press) Issue: 5 Pages: 458-466
- DOI
  10.1242/bio.2012638
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22123005, KAKENHI-PROJECT-22501010
[Journal Article] What we learn from transformation suppressor genes : lessons from RECK.2010
- Author(s)
  Noda, M., Takahashi, C., Matsuzaki, T., Kitayama, H
- Journal Title
  
  Future Oncology
  
  Volume: 6 Pages: 1105-1116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501010
[Journal Article] Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice2010
- Author(s)
  Chandana P. S. E、Maeda Y、Ueda A、Kiyonari H、Oshima N、Yamamoto M、Kondo S、Oh J、Takahashi R、Yoshida Y、Kawashima S、Alexander. B. D、Kitayama H、Takahashi C、Tabata Y、Matsuzaki T、Noda M
- Journal Title
  
  BMC Developmental Biology
  
  Volume: Vol.10、No.84 Issue: 1 Pages: 1-13
- DOI
  10.1186/1471-213x-10-84
- NAID
  120002511238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590438, KAKENHI-PROJECT-22501010
[Journal Article] What we learn from transformation suppressor genes: lessons from RECK2010
- Author(s)
  Noda M, Takahashi C, Matsuzaki T, Kitayama H
- Journal Title
  
  Future Oncol.
  
  Volume: 6 Issue: 7 Pages: 1105-16
- DOI
  10.2217/fon.10.80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501010
[Journal Article] Noda MHypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs.2010
- Author(s)
  Loayza-Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H
- Journal Title
  
  Oncogene
  
  Volume: 29 Issue: 18 Pages: 2638-48
- DOI
  10.1038/onc.2010.23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501010
[Journal Article] Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs.2010
- Author(s)
  Loayza-Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H., Noda M.
- Journal Title
  
  Oncogene 29
  
  Pages: 2638-2648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs2010
- Author(s)
  Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M
- Journal Title
  
  Oncotarget
  
  Volume: 1 Pages: 252-64
- URL
  http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501010
[Journal Article] RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin.2009
- Author(s)
  Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, Okawa K, Kitayama H,, Takahashi C, Sato C, Noda M.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 3461-3469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts.2009
- Author(s)
  Morioka Y, Monypenny J, Matsuzaki T, Shi S, Alexander DB, Kitayama H., Noda M.
- Journal Title
  
  Oncogene 28
  
  Pages: 1454-1464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007
- Author(s)
  Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H,, Hiraki Y, Noda M.
- Journal Title
  
  J Cell Sci 120
  
  Pages: 849-857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Identification of Rg13 as a potential binding partner for Rap-family small G-proteins and profilin II.2007
- Author(s)
  Xu, J., Shi, S., Matsumoto, N., Noda, M. & Kitayama, H.
- Journal Title
  
  Cell Signal 19
  
  Pages: 1575-1582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II.2007
- Author(s)
  Xu J, Shi S, Matsumoto N, Noda M., Kitayama H
- Journal Title
  
  Cell Signal 19
  
  Pages: 1575-1582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007
- Author(s)
  Kondo, S., Shukunami, C., Morioka, Y., Matsumoto, N., Takahashi, R., Oh, J., Atsumi, T., Umezawa, A., Kudo, A., Kitayama, H., Hiraki, Y., Noda, M.
- Journal Title
  
  J.Cell.Sci. 120
  
  Pages: 849-857
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007
- Author(s)
  Kondo, S., Shukunami, C., Morioka, Y., Matsumoto, N., Takahashi, R., Oh, J., Atsumi, T., Umezawa, A., Kudo, A., Kitayama, H., Hiraki, Y. & Noda, M.
- Journal Title
  
  J Cell Sci 120
  
  Pages: 849-857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors.2005
- Author(s)
  Echizenya M, Kondo S, Takahashi R, Oh J, Kawashima S, Kitayama H,, Takahashi C, Noda M.
- Journal Title
  
  Oncogene 24
  
  Pages: 5850-5857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Effects of ras and Rap1 on electrical excitability of differentiated NG108-15 cells.2004
- Author(s)
  Imamura Y, Matsumoto N, Kondo S, Kitayama H, Noda M.
- Journal Title
  
  Neuroscience 127
  
  Pages: 973-981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Stetler-Stevenson WG. Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK.2004
- Author(s)
  Oh J, Seo DW, Diaz T, Wei B, Ward Y, Ray JM, Morioka Y, Shi S, Kitayama H, Takahashi C, Noda M.
- Journal Title
  
  Cancer Res 64
  
  Pages: 9062-9069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Rap1 mutants with increased affinity for the guanine-nucleotide exchange factor C3G.2004
- Author(s)
  Shi S, Noda M., Kitayama H
- Journal Title
  
  Oncogene 23
  
  Pages: 8711-8719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16GS0311
[Journal Article] Identification of Rg13 as a potential binding partner for Rap-family small G-proteins and profilin II.
- Author(s)
  Xu, J., Shi, S., Matsumoto, N., Noda, M., Kitayama, H.
- Journal Title
  
  Cell.Signal. (in press)
- Data Source
  KAKENHI-PROJECT-16GS0311
[Presentation] cDNA発現クローニング法を用いたRas制御因子の探索2012
- Author(s)
  清水正樹、施恭平、野田亮、北山仁志
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22501010
[Presentation] cDNA 発現クローニング法を用いたRas制御因子の探索2012
- Author(s)
  清水正樹、施恭平、野田亮、北山仁志
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22501010

1. NODA Makoto (30146708)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
2. MATSUZAKI Tomoko (50402855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. YOSHIDA Yoko (60130324)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. IMAMURA Yukio (90447954)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 木下専 (30273460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IKAWA Yoji (40085618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMURA Yasuko (50146809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SATOH Singo (10143562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MABUCHI Issei (40012520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HOSOYA Hiroshi (90183102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NUMATA Osamu (50189354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HAMAGUCHI Yukihisa (70016161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANAKA Kazuma (60188290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TOMIMOTO Hidekazu (80324648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AKIGUCHI Ichiro (30115779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 佐々木正夫 (20013857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 押村光雄 (20111619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 横田淳 (10191503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 宇都宮譲二 (70013901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高井新一郎 (80028513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 近藤科江 (40314182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 渡辺良雄 (00015918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 丸山工作 (60012267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 石川春律 (90010058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 高橋玲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitayama Hitoshi 北山 仁志

KITAYAMA Hitoshi 北山 仁志

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Identification of the genes regulate Ras-mediated signalingby cDNA expression cloning methodPrincipal Investigator

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細胞形態制御における細胞質骨格蛋白セプチンの機能解析Principal Investigator

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低分子量Gタンパク質Krev-1の機能解析Principal Investigator

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[Journal Article] The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs2012

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DOI

Data Source

[Journal Article] What we learn from transformation suppressor genes : lessons from RECK.2010

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[Journal Article] Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice2010

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DOI

NAID

Data Source

[Journal Article] What we learn from transformation suppressor genes: lessons from RECK2010

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DOI

Kitayama Hitoshi 北山仁志

KITAYAMA Hitoshi 北山仁志