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Kitayama Hitoshi  北山 仁志

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KITAYAMA Hitoshi  北山 仁志

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Researcher Number 30231286
Other IDs
Affiliation (Current) 2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2012: 京都大学, 医学(系)研究科(研究院), 准教授
2010 – 2012: 京都大学, 医学研究科, 准教授
2009: 京都大学, 医学研究科, 助教授
2000 – 2004: 京都大学, 医学研究科, 助教授
2002: 京都大学, 医学研究科, 教授 … More
2001 – 2002: 京都大学, 大学院・医学研究科, 助教授
1999: 京都大学, 大学院・医学研究科, 助教授
1998: 京都大学, 医学研究科, 助手
1997: 京都大学, 大学院・医学研究科, 助手
1992 – 1994: 理化学研究所, ライフサイエンス筑波研究センター, 研究員 Less
Review Section/Research Field
Principal Investigator
Tumor biology / Biological Sciences / Molecular biology
Except Principal Investigator
General medical chemistry / Biological Sciences / Neurology / Pathological medical chemistry
Keywords
Principal Investigator
がん制御遺伝子 / エクソサイトーシス / 分泌 / アクチンストレスファイバー / GTPアーゼ / 細胞骨格 / two-hybrid法 / 遺伝子欠損マウス / 細胞質分裂 / グリア … More / シナプス小胞 / 神経細胞 / CDC10 / CDCrel-1 / 遺伝子欠陥マウス / Cdc42 / Borg / H5 / Nedd5 / セプチン / two-hybridアッセイ / two-hybrid アッセイ / Ras / Krev-1 … More
Except Principal Investigator
シグナル伝達 / MMP / c-IAP2 / TMX / septin / RECK / MT1-MMP / MMP-2 / Lewy body / H5 / Septin / TGF-β / signal transduction / 発生 / チオレドキシン / TGF-beta / エンハンサートラップ / エンハンサー・トラップ / Lewy小体 / パーキンソン病 / セプチン / endomucin / Ras / C3G / Rap1 / Glial cytoplasmic inclusion(GCI) / αsynuclein / Proteasome / Synphilin / 多系統萎縮症 / ubiquitin / α-synuclein / sepin / 黒質 / glial cytoplasmic inclusion(GCI) / glial cytoplasmic inclusion (GCI) / αシヌクレイン / プロテアゾーム / synphilin-1 / blood vessel / collagen / metastasis / invasion / cancer / Extracellular matrix / 転移抑制 / 軟骨 / VGEF / がん転移 / 血管新生 / RAS / 膵癌 / central core disease / 遺伝子欠損マウス / 筋肉 / 血管 / コラーゲン / 転移 / 浸潤 / 癌 / 細胞外マトリックス / X-ray-responsive genes / bleomycin / ER stress / thioredoxin / retroviral vector / 遺伝子発現 / Bax / NF-kB / X線 / レトロウイルスベクター / X線応答遺伝子 / ブレオマイシン / 小胞体ストレス / レトロウイスルベクター / contractile ring / myosin / actin / cytoskeleton / cell division / biomolecules / cell, tissue / PJ10 / 微小管 / Rho / 分裂シグナル / 分裂溝 / リン酸化 / アクチン調節タンパク質 / 低分子量Gタンパク質 / 細胞質分裂 / 細胞組織 / 収縮環 / ミオシン / アクチン / 細胞骨格 / 細胞分裂 / 生体分子 / 細胞・組織 / Pain-increased Krev-1 expression / Krev-1 expression / novel Ras function / erythropoietin receptor / small G protein / tumour suppressor gene / 増殖抑制遺伝子 / IL-2受容体 / Krev-1の痛み刺激による増強 / Krev-1蛋白の局在 / 新たなRas機能 / エリスロポエチン受容体 / 小分子量G蛋白質 / 癌抑制遺伝子 / 精子形成 / 甲状腺腫瘍 / N-Ras / Rb / 筋肉発生 / MRF / Sept4 / profilin II / Rg13 / CD13 / 軟骨分化 / 発現遺伝子プロファイリング / 条件的遺伝子欠損マウス / 酸素濃度 / 血清濃度 / 細胞密度 / 細胞移動 / fibronectin / 細胞マトリックス / Notch / ADAM / マウス遺伝学 / がん / PC12 / NGFI-A / RAP1 / ニューロトロフィン / 神経突起 / sindbis virus / RGL3 / グルタミン酸受容体 / 海馬 / シンドビズ・ウイルス / コロイドプレキサス / 遺伝性腫瘍 / ウイルムス腫瘍 / 網膜芽細胞腫 / 家族性大腸ポリポージス / 突然変異 / 発がん / ヘテロ接合性の消失 / がん抑制遺伝子 Less
  • Research Projects

    (11 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (25 People)
  •  Identification of the genes regulate Ras-mediated signalingby cDNA expression cloning methodPrincipal Investigator

    • Principal Investigator
      KITAYAMA Hitoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Kyoto University
  •  Roles and Regulatory Mechanisms of Extracellular Matrix Remodeling in vivo

    • Principal Investigator
      NODA Makoto
    • Project Period (FY)
      2004 – 2009
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Kyoto University
  •  significance of septin in the formation of inclusion bodies in neurodegenerative disorders.

    • Principal Investigator
      TOMIMOTO Hidekazu
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University
  •  Studies on the roles of the membrane-associated matrix metalloproteinase regulator BECK in angiogenesis

    • Principal Investigator
      NODA Makoto
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      KYOTO UNIVERSITY
  •  神経突起伸長に関与する分子の探索と機能解析

    • Principal Investigator
      野田 亮
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Screening for signal-responsive genes by an enhancer-trap vector and their application

    • Principal Investigator
      NODA Makoto
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      KYOTO UNIVERSITY
  •  細胞形態制御における細胞質骨格蛋白セプチンの機能解析Principal Investigator

    • Principal Investigator
      北山 仁志, 木下 専
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (B)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Mechanisms of formation and destruction of the contractile ring during cytokinesis

    • Principal Investigator
      MABUCHI Issei
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  低分子量Gタンパク質Krev-1の機能解析Principal Investigator

    • Principal Investigator
      北山 仁志
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      Kyoto University
  •  がん抑制に関与する遺伝子群の研究

    • Principal Investigator
      佐々木 正夫
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  Investigation of physiological function of the cell growth-regulating G-proteins and their signaling pathways.

    • Principal Investigator
      IKAWA Yoji
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

All 2012 2010 2009 2007 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs2012

    • Author(s)
      Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M
    • Journal Title

      Biology Open

      Volume: (in press) Issue: 5 Pages: 458-466

    • DOI

      10.1242/bio.2012638

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22123005, KAKENHI-PROJECT-22501010
  • [Journal Article] What we learn from transformation suppressor genes : lessons from RECK.2010

    • Author(s)
      Noda, M., Takahashi, C., Matsuzaki, T., Kitayama, H
    • Journal Title

      Future Oncology

      Volume: 6 Pages: 1105-1116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501010
  • [Journal Article] Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice2010

    • Author(s)
      Chandana P. S. E、Maeda Y、Ueda A、Kiyonari H、Oshima N、Yamamoto M、Kondo S、Oh J、Takahashi R、Yoshida Y、Kawashima S、Alexander. B. D、Kitayama H、Takahashi C、Tabata Y、Matsuzaki T、Noda M
    • Journal Title

      BMC Developmental Biology

      Volume: Vol.10、No.84 Issue: 1 Pages: 1-13

    • DOI

      10.1186/1471-213x-10-84

    • NAID

      120002511238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590438, KAKENHI-PROJECT-22501010
  • [Journal Article] What we learn from transformation suppressor genes: lessons from RECK2010

    • Author(s)
      Noda M, Takahashi C, Matsuzaki T, Kitayama H
    • Journal Title

      Future Oncol.

      Volume: 6 Issue: 7 Pages: 1105-16

    • DOI

      10.2217/fon.10.80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501010
  • [Journal Article] Noda MHypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs.2010

    • Author(s)
      Loayza-Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H
    • Journal Title

      Oncogene

      Volume: 29 Issue: 18 Pages: 2638-48

    • DOI

      10.1038/onc.2010.23

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501010
  • [Journal Article] Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs.2010

    • Author(s)
      Loayza-Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H., Noda M.
    • Journal Title

      Oncogene 29

      Pages: 2638-2648

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs2010

    • Author(s)
      Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M
    • Journal Title

      Oncotarget

      Volume: 1 Pages: 252-64

    • URL

      http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501010
  • [Journal Article] RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin.2009

    • Author(s)
      Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, Okawa K, Kitayama H,, Takahashi C, Sato C, Noda M.
    • Journal Title

      J Biol Chem 284

      Pages: 3461-3469

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts.2009

    • Author(s)
      Morioka Y, Monypenny J, Matsuzaki T, Shi S, Alexander DB, Kitayama H., Noda M.
    • Journal Title

      Oncogene 28

      Pages: 1454-1464

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007

    • Author(s)
      Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H,, Hiraki Y, Noda M.
    • Journal Title

      J Cell Sci 120

      Pages: 849-857

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Identification of Rg13 as a potential binding partner for Rap-family small G-proteins and profilin II.2007

    • Author(s)
      Xu, J., Shi, S., Matsumoto, N., Noda, M. & Kitayama, H.
    • Journal Title

      Cell Signal 19

      Pages: 1575-1582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II.2007

    • Author(s)
      Xu J, Shi S, Matsumoto N, Noda M., Kitayama H
    • Journal Title

      Cell Signal 19

      Pages: 1575-1582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007

    • Author(s)
      Kondo, S., Shukunami, C., Morioka, Y., Matsumoto, N., Takahashi, R., Oh, J., Atsumi, T., Umezawa, A., Kudo, A., Kitayama, H., Hiraki, Y., Noda, M.
    • Journal Title

      J.Cell.Sci. 120

      Pages: 849-857

    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.2007

    • Author(s)
      Kondo, S., Shukunami, C., Morioka, Y., Matsumoto, N., Takahashi, R., Oh, J., Atsumi, T., Umezawa, A., Kudo, A., Kitayama, H., Hiraki, Y. & Noda, M.
    • Journal Title

      J Cell Sci 120

      Pages: 849-857

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors.2005

    • Author(s)
      Echizenya M, Kondo S, Takahashi R, Oh J, Kawashima S, Kitayama H,, Takahashi C, Noda M.
    • Journal Title

      Oncogene 24

      Pages: 5850-5857

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Effects of ras and Rap1 on electrical excitability of differentiated NG108-15 cells.2004

    • Author(s)
      Imamura Y, Matsumoto N, Kondo S, Kitayama H, Noda M.
    • Journal Title

      Neuroscience 127

      Pages: 973-981

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Stetler-Stevenson WG. Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK.2004

    • Author(s)
      Oh J, Seo DW, Diaz T, Wei B, Ward Y, Ray JM, Morioka Y, Shi S, Kitayama H, Takahashi C, Noda M.
    • Journal Title

      Cancer Res 64

      Pages: 9062-9069

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Rap1 mutants with increased affinity for the guanine-nucleotide exchange factor C3G.2004

    • Author(s)
      Shi S, Noda M., Kitayama H
    • Journal Title

      Oncogene 23

      Pages: 8711-8719

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Journal Article] Identification of Rg13 as a potential binding partner for Rap-family small G-proteins and profilin II.

    • Author(s)
      Xu, J., Shi, S., Matsumoto, N., Noda, M., Kitayama, H.
    • Journal Title

      Cell.Signal. (in press)

    • Data Source
      KAKENHI-PROJECT-16GS0311
  • [Presentation] cDNA発現クローニング法を用いたRas制御因子の探索2012

    • Author(s)
      清水正樹、施恭平、野田亮、北山仁志
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-22501010
  • [Presentation] cDNA 発現クローニング法を用いたRas制御因子の探索2012

    • Author(s)
      清水正樹、施恭平、野田亮、北山仁志
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-22501010
  • 1.  NODA Makoto (30146708)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 14 results
  • 2.  MATSUZAKI Tomoko (50402855)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  YOSHIDA Yoko (60130324)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  IMAMURA Yukio (90447954)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  木下 専 (30273460)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  IKAWA Yoji (40085618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YAMAMURA Yasuko (50146809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SATOH Singo (10143562)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MABUCHI Issei (40012520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HOSOYA Hiroshi (90183102)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NUMATA Osamu (50189354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HAMAGUCHI Yukihisa (70016161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TANAKA Kazuma (60188290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TOMIMOTO Hidekazu (80324648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  AKIGUCHI Ichiro (30115779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  佐々木 正夫 (20013857)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  押村 光雄 (20111619)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  横田 淳 (10191503)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  宇都宮 譲二 (70013901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  高井 新一郎 (80028513)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  近藤 科江 (40314182)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  渡辺 良雄 (00015918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  丸山 工作 (60012267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  石川 春律 (90010058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  高橋 玲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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