Oshimura Mitsuo 押村光雄

… Alternative Names

Researcher Number	20111619
Other IDs
External Links
Affiliation (Current)	2019: 鳥取大学, 染色体工学研究センター, 特任教授
Affiliation (based on the past Project Information) *help	2014 – 2017: 鳥取大学, 染色体工学研究センター, 特任教授 2014: 鳥取大学, 大学院医学系研究科, 教授 2013: 鳥取大学, 染色体工学研究センター, 教授 2011: 鳥取大学, 大学院・医学系・研究科, 教授 2006 – 2011: 鳥取大学, 大学院・医学系研究科, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Human genetics / Human genetics / 基礎ゲノム科学 / Pediatrics / Laboratory animal science / Cerebral neurosurgery / Immunology Except Principal Investigator Urology / Immunology … More
Keywords	Principal Investigator 染色体導入 / 染色体工学 / FISH / がん抑制遺伝子 / ヒト21番染色体 / DT40 / ヒト人工染色体 / 染色体移入 / 微小核細胞融合法 / モデルマウス … More Except Principal Investigator がん抑制遺伝子 / 染色体移入 / ヒト正常細胞 / 老化 / 無限増殖性化 / 癌化 / 染色体 / 遺伝子 / 発がん / ヒト3番染色体 / 微小核細胞融合 / ヘテロ接合性の消失 / 突然変異 / 家族性大腸ポリポージス / 網膜芽細胞腫 / ウイルムス腫瘍 / 遺伝性腫瘍 / ラット / 遺伝性腎細胞がん / SCIDマウス / 放射線感受性の補正 / ヒト8番染色体 / Ekerラット / 遺伝性腎癌 / 子宮平滑筋肉腫 / MNNGによる形質転換腎上皮細胞 / 第5染色体欠失 / 第6染色体欠失 / IFNα領域の遺伝子欠損 / ヒト腎細胞がん / ガス抑制遺伝子 / サブトラクション法 / 遺伝子発現 / Ekerラット遺伝性腎癌 / 微小微小核融合法 / INFα遺伝子 / TSC2遺伝子 / ゲノム刷り込み / 刷り込みドメイン / siRNAライブラリー / non-coding RNA / ヒストンメチル化 / 抗体医薬 / 人工染色体 / 抗体医薬産生 / シトリン欠損症 / マウスモデル / 糖質毒性 / アスパラギン酸グルタミン酸ミトコンドリア膜輸送体 / ピルビン酸ナトリウム / アミノ酸 / グリセロール3－リン酸 / グリセロール / ヒト21番染色体 / 胚性幹細胞 / キメラマウス / ヒト染色体 / 胚幹細胞 / ES細胞 / マウス / キメラ / microcell-mediated chromosome transfer / human chromosome 21 / mouse embryonic stem cell / chimeric mouse / がん遺伝子 / ヒトレトロウイルス / ヒトがん遺伝子 / DNA修復 / サイトカイン / 増殖因子 / International Exchange Program / Human Gene Mapping / Oncogenes / Tumor Suppressor Genes / Cytokines / Growth Factors / French-Japanese collaborative programe in cancer research / German-Japanese collaborative program in cancer research Less

The elucidation of the carcinogenic mechanism of the Down's syndrome using chromosome engineering technologyPrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Development of a novel model animal generation system using a mouse artificial chromosomePrincipal Investigator
- Principal Investigator
  
  Mitsuo Oshimura
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Tottori University
To developtherapeutic and prophylactic procedures for citrin deficiency
- Principal Investigator
  
  SAHEKI Takeyori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
Development of the antibody drug production system using a highly efficient artificial chromosome vector.
- Principal Investigator
  
  NISHIDA Tadashi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Tottori University
Gene therapy of Duchenne muscular dystrophy using own stem cells and human artificial chromosomePrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
除去可能である新規遺伝子治療用人工染色体ベクターの開発Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
新規M期チェックポイントタンパクに着目する発がんにおける染色体不安定説の検証Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Construction of human artificial chromosome for gene therapy of Duchenne muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
siRNAライブラリーを用いた刷り込み遺伝子発現調節分子の同定
- Principal Investigator
  
  副島英伸
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Saga University
一卵性双生児ゲノム解析によるヒト個体差を作り出すゲノム領域の同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  基礎ゲノム科学
- Research Institution
  Tottori University
染色体改変に基づく新規ヒト人工染色体ベクターの構築Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
Genome-wide analysis of genomic impinting in cancerPrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori Univeisity
ヒト21番染色体を保持するダウン症候群モデルマウスの作出とその原因遺伝子同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Generation of human chromosome-specific monoclonal antibodies using trans-chromosomic (TC) micePrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tottori University
ヒト21番染色体を保持するダウン症候群モデルマウスの作出とその原因遺伝子同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Generation of ES cells that stably its translocation to mouse chromosomePrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
The development of animal model for chromosome trisomy-syndrome by microcell-mediated chromosome transfer
- Principal Investigator
  
  FUNAKI Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shimane University
染色体導入による転移抑制遺伝子の同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
グリオーマにおけるテロメレース活性およびテロメア長の臨床応用への検討Principal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  TOTTORI UNIVERSITY
腎細胞の発癌過程におけるINFα領域の遺伝子欠損の意義
- Principal Investigator
  
  舟木賢治
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Tottori University
腎細胞がんの腫瘍形質抑制に伴いその発現が変化する遺伝子の解析
- Principal Investigator
  
  清水素行
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Tottori University
特定染色体導入によるがん抑制遺伝子の同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tottori University
SCIDマウスの放射線感受性を補正するヒト8番染色体上遺伝子の単離
- Principal Investigator
  
  清水素行
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tottori University
Ekerラット遺伝性腫瘍の原因遺伝子マッピング
- Principal Investigator
  
  FUNAKI Kenji
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
がん抑制に関与する遺伝子群の研究
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
特定染色体導入によるがん抑制遺伝子の同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tottori University
腎細胞がん高発ラット細胞株を用いたヒト腎細胞がんのがん抑制遺伝子の解析
- Principal Investigator
  
  清水素行
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Tottori University
Chromosomal mupping of a gene responsible for Bloom syndrome via microcell-mediated chromosome TransferPrincipal Investigator
- Principal Investigator
  
  OSHIMURA Mitsuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tottori University
特定染色体導入によるがん抑制遺伝子の同定Principal Investigator
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tottori University
ヒト細胞の無限増殖性化に関与する染色体、遺伝子、およびその遺伝子機能に関する研究
- Principal Investigator
  
  難波正義
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kawasaki Medical School
ヒト細胞の無限増殖性化に関与する染色体、遺伝子、および遺伝子機能に関する研究
- Principal Investigator
  
  難波正義
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kawasaki Medical School
Cooperation and Information Exchange with European Countries
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Medical Science, University of Tokyo

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004

All Journal Article Presentation Book

[Book] 進化するゲノム編集技術、真下知士　城石俊彦　監修2015
- Author(s)
  香月康宏、押村光雄
- Total Pages
  341
- Publisher
  （株）NTS
- Data Source
  KAKENHI-PROJECT-25221308
[Book] 進化するゲノム編集技術、真下知士　城石俊彦　監修2015
- Author(s)
  香月康宏、押村光雄
- Total Pages
  341
- Publisher
  （株）NTS
- Data Source
  KAKENHI-PROJECT-25640049
[Book] ES・iPS細胞実験スタンダード、中辻憲夫　監修・末盛博文　編集2014
- Author(s)
  香月康宏、押村光雄
- Total Pages
  205
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25221308
[Book] 今すぐ始めるゲノム編集、山本卓　編集2014
- Author(s)
  香月康宏、押村光雄
- Total Pages
  355
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25221308
[Book] 実験医学別冊2014
- Author(s)
  香月康宏、押村光雄（中辻憲夫　監修/末盛博文　編集）
- Total Pages
  355
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25640049
[Book] In vitro毒性・動態評価の最前線、小島肇夫　監修2013
- Author(s)
  香月康宏、押村光雄
- Total Pages
  204
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-25221308
[Book] In vitro毒性・動態評価の最前線、小島肇夫　監修2013
- Author(s)
  香月康宏、押村光雄
- Total Pages
  204
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-25640049
[Book] 幹細胞とヒト人工染色体ベクターの出会いVol.19, No.12007
- Author(s)
  香月康宏、押村光雄
- Publisher
  アニテックス
- Data Source
  KAKENHI-PROJECT-18390107
[Book] ヒト人工染色体ベクター導入と遺伝子・再生医療への可能性vol.10No.42006
- Author(s)
  香月康宏、押村光雄
- Publisher
  分子呼吸器病
- Data Source
  KAKENHI-PROJECT-18390107
[Book] 11Vol.5 No.42006
- Author(s)
  平塚正治、押村光雄
- Publisher
  再生医療
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9.2018
- Author(s)
  Honma Kazuhisa、Abe Satoshi、Endo Takeshi、Uno Narumi、Oshimura Mitsuo、Ohbayashi Tetsuya、Kazuki Yasuhiro
- Journal Title
  
  PLoS One
  
  Volume: 13
- DOI
  10.1371/journal.pone.0193642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-15K12141
[Journal Article] Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics.2018
- Author(s)
  Satoh Daisuke、Abe Satoshi、Kobayashi Kaoru、Nakajima Yoshihiro、Oshimura Mitsuo、Kazuki Yasuhiro
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 33 Pages: 17-30
- DOI
  10.1016/j.dmpk.2018.01.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-15H04285, KAKENHI-PROJECT-16H03295, KAKENHI-PROJECT-16K18942
[Journal Article] Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models2017
- Author(s)
  Uno Narumi、Abe Satoshi、Oshimura Mitsuo、Kazuki Yasuhiro
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Pages: 145-156
- DOI
  10.1038/s10038-017-0378-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-15H04285, KAKENHI-PROJECT-15K19615
[Journal Article] Transfer of a mouse artificial chromosome into spermatogonial stem cells generates transchromosomic mice.2017
- Author(s)
  Shinohara T, Kazuki K, Ogonuki N, Morimoto H, Matoba S, Hiramatsu K, Honma K, Suzuki T, Hara T, Ogura A, Oshimura M, Kanatsu-Shinohara M, Kazuki Y.
- Journal Title
  
  Stem Cell Rep.
  
  Volume: 9(4) Pages: 1180-1191
- DOI
  10.1016/j.stemcr.2017.08.012
- NAID
  120006348286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08136, KAKENHI-PUBLICLY-17H05639, KAKENHI-PLANNED-25112003, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-16H06146, KAKENHI-PROJECT-15K14362, KAKENHI-PROJECT-15K15013
[Journal Article] Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome2017
- Author(s)
  Tomimatsu K, Kokura K, Nishida T, Yoshimura Y, Kazuki Y, Narita M, Oshimura M, Ohbayashi T.
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 7 Pages: 306-317
- DOI
  10.1002/2211-5463.12169
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-16K08548, KAKENHI-PROJECT-15K12141
[Journal Article] Highly efficient transfer of chromosomes to a broad range of target cells using Chinese hamster ovary cells expressing murine leukemia virus-derived envelope proteins.2016
- Author(s)
  Suzuki T, Kazuki Y, Oshimura M, Hara T.
- Journal Title
  
  PLoS ONE
  
  Volume: 11
- DOI
  10.1371/journal.pone.0157187
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-15H04285, KAKENHI-PROJECT-16H04728
[Journal Article] Studies of tumor suppressor genes via chromosome engineering2016
- Author(s)
  Kugoh H, Ohira T, Oshimura M.
- Journal Title
  
  Cancers
  
  Volume: 8 Pages: 4-4
- DOI
  10.3390/cancers8010004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08304, KAKENHI-PROJECT-25221308
[Journal Article] A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells.2016
- Author(s)
  Kokura K, Kuromi Y, Endo T, Anzai N, Kazuki Y, Oshimura M, Ohbayashi T.
- Journal Title
  
  J Gene Med
  
  Volume: 18 Pages: 273-281
- DOI
  10.1002/jgm.2925
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-26461258, KAKENHI-PROJECT-16K08548
[Journal Article] Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.2015
- Author(s)
  Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M
- Journal Title
  
  BMC Biotechnol
  
  Volume: 15 Pages: 58-58
- DOI
  10.1186/s12896-015-0142-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01291, KAKENHI-PROJECT-26460275, KAKENHI-PROJECT-26860733, KAKENHI-PROJECT-25221308
[Journal Article] A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.2015
- Author(s)
  Oshimura Mitsuo, Uno Narumi, Kazuki Yasuhiro, Katoh Motonobu, Inoue Toshiaki
- Journal Title
  
  Chromosome Res.
  
  Volume: 23 Pages: 111-133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570005, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-25640049, KAKENHI-PROJECT-15K07158
[Journal Article] Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation.2015
- Author(s)
  Yoshimura Y, Nakamura K, Endo T, Kajitani N, Kazuki K, Kazuki Y, Kugoh H, Oshimura M, Ohbayashi T.
- Journal Title
  
  Transgenic Res.
  
  Volume: 24(4) Pages: 717-27
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12141, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-25540134, KAKENHI-PROJECT-25640049
[Journal Article] A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome. human artificial chromosome.2014
- Author(s)
  Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura, and Takahiko Hara
- Journal Title
  
  PLoS One.
  
  Volume: 9
- DOI
  10.1371/journal.pone.0110404
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790696, KAKENHI-PROJECT-25221308
[Journal Article] Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.2014
- Author(s)
  Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimizu R, Nakauchi H, Yamamoto T, Oshimura M
- Journal Title
  
  Sci Rep
  
  Volume: 4 Pages: 6136-6136
- DOI
  10.1038/srep06136
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-25640044, KAKENHI-PROJECT-25713037, KAKENHI-PROJECT-25890014
[Journal Article] Highly stable maintenance of a mouse artificial chromosome in human cells and mice.2013
- Author(s)
  Kazuki K, Takehara S, Uno N, Imaoka N, Abe S, Takiguchi M, Hiramatsu K, Oshimura M, Kazuki Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 442 Pages: 44-50
- DOI
  10.1016/j.bbrc.2013.10.171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-25640049
[Journal Article] Stem cell-mediated transfer of a human artificial chromosome ameliorates muscular dystrophy2011
- Author(s)
  Tedesco FS, Hoshiya H, D' Antona G, Gerli MF, Messina G, Antonini S, Tonlorenzi R, Benedetti S, Berghella L, Torrente Y, Kazuki Y, Bottinelli R, Oshimura M, Cossu G.
- Journal Title
  
  Sci Transl Med
  
  Volume: Volume 3, number 96 Pages: 96-78
- DOI
  10.1126/scitranslmed.3002342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] ヒト人工染色体ベクターによる遺伝子細胞治療へ向けて2011
- Author(s)
  香月康宏、押村光雄
- Journal Title
  
  日本臨床
  
  Volume: Vol.69, No.12 Pages: 2142-7
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] Refined human artificial chromosome vectors for gene therapy and animal transgenesis2011
- Author(s)
  Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N and Oshimura M
- Journal Title
  
  Gene The
  
  Volume: Volume 18, number 4 Pages: 384-93
- DOI
  10.1038/gt.2010.147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249022, KAKENHI-PROJECT-22590301
[Journal Article] Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models2011
- Author(s)
  Kazuki Y, Oshimura M.
- Journal Title
  
  Molecular Therapy
  
  Volume: Volume 19, number 9 Pages: 1591-1601
- DOI
  10.1038/mt.2011.136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] ヒト人工染色体ベクターの利点とその応用2010
- Author(s)
  山口繁幸、大林徹也、香月康宏、押村光雄
- Journal Title
  
  生化学
  
  Volume: Vol.82, No.9 Pages: 846-852
- NAID
  10027502606
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] Complete genetic correction of iPS cells from Duchenne muscular dystrophy2010
- Author(s)
  Kazuki Y., Hiratsuka M., Takiguchi M., Osaki M., Kajitani N., Hoshiya H., Hiramatsu K., Yoshino T., Kazuki K., Ishihara C., Takehara S., Higaki K., Nakagawa M., Takahashi K., Yamanaka S. and Oshimura M.
- Journal Title
  
  Mol. Therapy
  
  Volume: Volume18, number 2 Pages: 386-93
- DOI
  10.1038/mt.2009.274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] 筋ジストロフィー患者由来のiPS細胞における遺伝子修復~ヒト人工染色体ベクターによる新たな遺伝子治療戦略の可能性2010
- Author(s)
  香月康宏、押村光雄
- Journal Title
  
  Medical Bio
  
  Volume: Vol.7, No.2 Pages: 58-63
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] 幹細胞のゲノム操作:ヒト人工染色体ベクターの開発2009
- Author(s)
  香月康宏、押村光雄
- Journal Title
  
  ゲノム医学
  
  Volume: Vol.9, No.3 Pages: 37-40
- Data Source
  KAKENHI-PROJECT-21249022
[Journal Article] Correction of a genetic defect in multipotentGermline stem cells using a human artificial chromosome2008
- Author(s)
  Kazuki Y., Hoshiya H., Kai Y., Abe S., Takiguchi M., Osaki M.,Kawazoe S., Katoh M., Kanatsu-Shinohara M., Inoue K., Kajitani N., Yoshino N., Shirayoshi Y., Ogura A., Shinohara T., BarrettJC., Oshimura M.
- Journal Title
  
  Gene Therapy 15
  
  Pages: 617-24
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] Transfer human artificial chromosome vectors into stem cells2008
- Author(s)
  Oshimura M., Katoh M.
- Journal Title
  
  Reproductive BioMedicine Online Vol.16 No.1
  
  Pages: 57-69
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] A highly stable and non-integrated human artificial chromosome(HAC) containing the 2.4Mb entire human dystrophin gene2008
- Author(s)
  Hoshiya H., Kazuki Y., Abe S., Takiguchi M., Kajitani N., Watanabe Y., Yoshino T.,Shirayoshi Y., Higaki K., Messina G., Cossu G., Oshimura M.,
- Journal Title
  
  Mol. Therapy
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] Transfer of human artificial chromosome vectors into stem cells.2008
- Author(s)
  Oshimura M
- Journal Title
  
  Reprod Biomed Online. 16
  
  Pages: 57-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector2008
- Author(s)
  Shitara S, Kakeda M, Nagata K, Hiratsuka M, Sano A, Osawa K, Okazaki A, Katoh M, Kazuki Y, Oshimura M, Tomizuka K
- Journal Title
  
  Biochem Biophys Res Commun Volume 369, number 3
  
  Pages: 807-11
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] Human artificial chromosome vectors meet stem cells : new prospects for gene delivery2006
- Author(s)
  Ren X, Tahimic CG, Katoh M, Kurimasa A, Inoue T, Oshimura M
- Journal Title
  
  Stem Cell Rev 2
  
  Pages: 43-50
- Data Source
  KAKENHI-PROJECT-18390107
[Journal Article] Loss of imprinting of PEG1/MEST in lung cancer cell lines.2004
- Author(s)
  Nakanishi, H., Suda, T., Katoh, M., Watanabe, A., Igishi, T., Kodani, M., Matsumoto, S., Nakamoto, M., Shigeoka, Y, Okabe, T., Oshimura, M., Shimizu, E.
- Journal Title
  
  Oncol.Rep. 12
  
  Pages: 1273-1278
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14026029
[Journal Article] Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.2004
- Author(s)
  Yu, W, Ginjala, V., Pant, V., Chernukhin, I., Whitehead, J., Docquier, F., Farrar, D., Tavoosidana, G., Mukhopadhyay, R., Kanduri, C., Oshimura.M..Feinberg, AP., Lobanenkov, V., Klenova, E., Ohlsson, R.
- Journal Title
  
  Nat.Genet. 36
  
  Pages: 1105-1110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14026029
[Journal Article] Silencing of imprinted p57^<KIP2> gene expression is associated with loss of lustone H31ysine 9 methylation at DMR-LIT 1 in esophageal cancer.2004
- Author(s)
  Soejima, H., Nakagawachi, T., Wei Z., Urano, T., Matsuoka, S., Higashimoto, K., Kitajima, Y., Takeuchi, M., Nakayama, M., Oshimura, M., Miyazaki, K., Joh, K., Mukai, T.
- Journal Title
  
  Oncogene 23
  
  Pages: 4380-4388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14026029
[Journal Article] Dicer is essential for formation of the heterochromatin structure in vertebrate cells.2004
- Author(s)
  Fukagawa, T., Nogami, M., Yoshikawa, M., Ikeno, M., Okazaki, T., Takami, Y., Nakayama, T., Oshimura, M.
- Journal Title
  
  Nat.Cell.Biol. 6
  
  Pages: 784-791
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14026029
[Journal Article] Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines.2004
- Author(s)
  Maegawa, S., Itaba, N., Otsuka, S., Kamitani, H., Watanabe, T., Tahimic, CGT., Nanba, E., Oshimura.M.
- Journal Title
  
  DNA Resarch 11
  
  Pages: 37-49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14026029
[Journal Article] Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST flanking region at human chromosome 7q32.2004
- Author(s)
  Yamada, T., Mitsuya, K., Kayashima, T., Yamasaki, K., Ohta, T., Yoshiura, K., Matsumoto, N., Yamada, H., Minakami H., Oshimura, M., Niikawa, N., Kishino, T.
- Journal Title
  
  Genomics. 83
  
  Pages: 402-412
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14026029
[Presentation] 鳥取大学発・世界最先端の染色体医工学技術を主軸とした新産業創出構想2017
- Author(s)
  押村光雄
- Organizer
  第7回北東アジア産業技術フォーラム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] ダウン症候群における白血病の病態解明に向けた病態モデル細胞の作製2017
- Author(s)
  矢倉裕奈、赤木智美、阿部智志、宇野愛海、香月加奈子、押村光雄、香月康宏
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] ヒト・マウス人工染色体導入マウス及び細胞の構築と限りない応用の可能性2017
- Author(s)
  押村光雄
- Organizer
  かずさDNA千葉県バイオ・ライフサイエンス・ネットワーク会議
- Invited
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] 染色体医工学技術を用いた疾患の原因究明、治療法の開発2017
- Author(s)
  久郷裕之, 宇野愛海, 大平崇人, 平塚正治, 香月康宏, 押村光雄
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] CHO-intermediated Chromosome Engineering (CHOiCE) technique using CRIPSR/Cas9.2016
- Author(s)
  Uno N, Uno K, Komoto S, Kazuki Y, and Oshimura M
- Organizer
  The 13th International Congress of Human Genetics (ICHG)
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] CHO細胞中におけるCRISPR/Cas9を用いた染色体改変技術の開発2016
- Author(s)
  10. 宇野愛海、宇野勝洋、古本真也、末松拓郎、香月康宏、押村光雄
- Organizer
  日本ゲノム編集学会第一回大会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] 人工染色体技術による創薬研究への応用2016
- Author(s)
  押村光雄
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25640049
[Presentation] 人工染色体技術による創薬研究への応用2016
- Author(s)
  押村光雄
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] Human and mouse artificial chromosomes for bio-medical charanges2015
- Author(s)
  Oshimura M.
- Organizer
  Future of Biomedicine 2015
- Place of Presentation
  Vladivostock, Russia
- Year and Date
  2015-09-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25640049
[Presentation] Human and mouse artificial chromosomes for bio-medical charanges2015
- Author(s)
  Oshimura M.
- Organizer
  Future of Biomedicine 2015
- Place of Presentation
  ウラジオストク、ロシア
- Year and Date
  2015-09-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] ヒト細胞とマウス個体において極めて安定に維持されるマウス人工染色体2014
- Author(s)
  宇野愛海、香月加奈子、嵩原昇子、今岡奈津子、阿部智志、滝口正人、平松敬、香月康宏、押村光雄
- Organizer
  第61回日本実験動物学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25640049
[Presentation] ヒト細胞とマウス個体において極めて安定に維持されるマウス人工染色体2014
- Author(s)
  宇野愛海、香月加奈子、嵩原昇子、今岡奈津子、阿部智志、滝口正人、平松敬、香月康宏、押村光雄
- Organizer
  第61回日本実験動物学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] 染色体工学技術とゲノム編集技術によるヒト化薬物代謝モデル動物の作製2014
- Author(s)
  香月康宏、小林カオル、平林真澄、佐久間哲史、久世治朗、阿部智志、滝口正人、平松敬、本間和久、梶谷尚世、嵩原昇子、香月加奈子、千葉寛、山本卓、押村光雄
- Organizer
  第61回日本実験動物学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] 染色体工学技術とゲノム編集技術の融合によるダウン症候群モデル細胞・動物の作製2014
- Author(s)
  香月康宏、押村光雄
- Organizer
  第4回ゲノム編集研究会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-10-06
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] New Vectors for Gene Delivery: Human and Mouse Artificial Chromosomes2013
- Author(s)
  Oshimura M.
- Organizer
  117th OMICS Group conference
- Place of Presentation
  USA
- Invited
- Data Source
  KAKENHI-PROJECT-25221308
[Presentation] New Vectors for Gene Delivery: Human and Mouse Artificial Chromosomes2013
- Author(s)
  Oshimura M.
- Organizer
  117th OMICS Group conference
- Place of Presentation
  USA
- Invited
- Data Source
  KAKENHI-PROJECT-25640049
[Presentation] Human artificial chromosomes for gene delivery and stable expression2012
- Author(s)
  Oshimura M
- Organizer
  11th Annual PEP TALK
- Place of Presentation
  SanDiego(Califolnia)
- Year and Date
  2012-01-09
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] 遺伝子発現ベクターとしての人工染色体2012
- Author(s)
  押村光雄
- Organizer
  文部科学省「再生医療の実現化プロジェクト」ヒト多能性幹細胞の培養・解析の標準化レクチャーシリーズ第6回「幹細胞の遺伝子操作の実践(つぼ)」
- Place of Presentation
  理化学研究所(兵庫県)(招待講演)
- Year and Date
  2012-02-02
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] APPLYING A HUMAN ARTIFICIAL CHROMOSOME VECTOR TO DE VELOP A HIGH-SENSITIVE BIOSENSOR CELL AS IN VITRO RISK ASSESSMENT METHOD2012
- Author(s)
  T. Nishida, Y. Yoshimura, Y. Nakajima, Y. Ohmiya, T. Ohbayashi, N. Tanaka and M. Oshimura
- Organizer
  2012Society of Toxicology Annual Meeting
- Place of Presentation
  Moscone convention center, San Francisco(USA)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22890114
[Presentation] Human artificial chromosomes for gene delivery and stable expression2012
- Author(s)
  Oshimura M
- Organizer
  11^<th> Annual PEP TALK
- Place of Presentation
  San Diego (Califolnia)
- Year and Date
  2012-01-09
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] 遺伝子発現ベクターとしての人工染色体2012
- Author(s)
  押村光雄
- Organizer
  再生医療の実現化プロジェクト」ヒト多能性幹細胞の培養・解析の標準化レクチャーシリーズ第6回「幹細胞の遺伝子操作の実践(つぼ)
- Place of Presentation
  理化学研究所(兵庫県)
- Year and Date
  2012-02-02
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] 人工染色体ベクターを用いた好感度毒性評価の作成2012
- Author(s)
  西田直史、吉村裕貴、佐々木勝崇、中島芳浩、押村光雄、大林徹也
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台国際センター(宮城)
- Data Source
  KAKENHI-PROJECT-22890114
[Presentation] Human artificial chromosomes for gene delivery2011
- Author(s)
  Oshimura M
- Organizer
  World stem cell summit
- Place of Presentation
  Pasadena(Califolnia)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] ヒト人工染色体を用いた遺伝子・再生医療への挑戦2011
- Author(s)
  押村光雄
- Organizer
  文部科学省iPS細胞等研究ネットワーク第3回合同シンポジウム
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] Development of a high-sensitivity toxicity test system using chromosome engineering and bioluminescence technology2011
- Author(s)
  T. Nishida, Y. Yoshimura, K. Sasaki, Y. Nakajima, R. Saito, Y. Kazuki, S. Nishii, Y. Ohmiya, S. Aiba, M. Oshimura and T. Ohbayashi
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22890114
[Presentation] 人工染色体を用いた遺伝子/再生医療2010
- Author(s)
  押村光雄
- Organizer
  第180回川崎医学会講演会
- Place of Presentation
  川崎医科大学(倉敷)
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] Human artificial chromosome and its medical and pharmaceutical applications2010
- Author(s)
  押村光雄
- Organizer
  The 4th Asian Chromosome Colloquium(ACC4) Plenary Lectures
- Place of Presentation
  Fragrant Hill Empark Hotel(北京・中国)
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-21249022
[Presentation] 多能性精原幹細胞(mGS)とヒト人工染色体ベクターを用いた欠損型遺伝子治療を目指して2008
- Author(s)
  阿部智志、香月康宏、星谷英寿、甲斐義輝、滝口正人、尾崎克彦、川添真史郎、加藤基伸、篠原美都、井上貴美子、梶谷尚世、吉野とう子、白吉安昭、小倉淳郎、篠原隆司、押村光雄
- Organizer
  第7回日本再生医療学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18390107
[Presentation] 遺伝子治療に向けた新規遺伝子治療用ヒト人工染色体ベクターの開発2008
- Author(s)
  香月康宏, 星谷英寿, 甲斐義輝, 阿部智志, 滝口正人, 飯田雄一, 渡辺義徳, 尾崎克彦, 梶谷尚世, 吉野とう子, 白吉安昭, 富松望, 平塚正治, 栗政明弘, 押村光雄
- Organizer
  第7回日本再生医療学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18390107
[Presentation] 新規ヒト人工染色体ベクターの構築 : サブテロメアを用いた高発現ベクター系2008
- Author(s)
  掛田実、永田恵子、佐野暁子、大澤加奈子、岡崎晃代、設楽真吾、香月康宏、押村光雄、富塚一磨
- Organizer
  第6回幹細胞シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390107
[Presentation] A novel human artificial chromosome (HAC) for gene therapy and animal transgenesis2008
- Author(s)
  Kazuki Y., Hoshiya H., Abe S., Takiguchi M., Iida Y., Watanabe Y., Osaki M., Katoh M., Kajitani N., Yoshino T., Shirayoshi Y., Hiratsuka M., Kurimasa K., and Oshimura M.
- Organizer
  ASGT 11th annual meeting
- Place of Presentation
  U.S.A.
- Data Source
  KAKENHI-PROJECT-18390107
[Presentation] ジストロフィンゲノムDNA(2.5Mb)を搭載したHAC ベクター : 遺伝子治療を目指して2008
- Author(s)
  星谷英寿、香月康宏、甲斐義輝、阿部智志、滝口正人、飯田雄一 ,渡辺義徳, 尾崎克彦、梶谷尚世,吉野とう子,白吉安昭 ,押村光雄
- Organizer
  第7回日本再生医療学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18390107
[Presentation] A human artificial chromosome (HAC) vector with about 2.4 Mb-human Dystrophin genome including native expression control elements2008
- Author(s)
  Hoshiya H., Kazuki Y., Abe S., Kai Y., Takiguchi M., Iida Y., Watanabe Y., Osaki M., Kajitani N., Yoshino T., Shirayoshi Y. and Oshimura M.
- Organizer
  ASGT 11^<th> annual meeting
- Place of Presentation
  U.S.A.
- Data Source
  KAKENHI-PROJECT-18390107
[Presentation] Functional restoration of a genetic defect in multipotent germline stem cells by human artificial chromosome containing a genomic insert2006
- Author(s)
  Kazuki Y., Hoshiya, H., Kai Y., Abe S., Takiguchi M., Osaki M., Kanatsu-Shinohara M., Kajitani N., ShirayoshiY., Hratsuka M., Ogura A., Shinohara T.and Oshimura, M
- Organizer
  ASGT 9^<th> annual meeting
- Place of Presentation
  U.S.A.
- Data Source
  KAKENHI-PROJECT-18390107

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Oshimura Mitsuo 押村 光雄

OSHIMURA Mitsuo 押村 光雄

Research Projects

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The elucidation of the carcinogenic mechanism of the Down's syndrome using chromosome engineering technologyPrincipal Investigator

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Development of a novel model animal generation system using a mouse artificial chromosomePrincipal Investigator

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Gene therapy of Duchenne muscular dystrophy using own stem cells and human artificial chromosomePrincipal Investigator

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除去可能である新規遺伝子治療用人工染色体ベクターの開発Principal Investigator

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新規M期チェックポイントタンパクに着目する発がんにおける染色体不安定説の検証Principal Investigator

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Construction of human artificial chromosome for gene therapy of Duchenne muscular dystrophyPrincipal Investigator

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一卵性双生児ゲノム解析によるヒト個体差を作り出すゲノム領域の同定Principal Investigator

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染色体改変に基づく新規ヒト人工染色体ベクターの構築Principal Investigator

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Genome-wide analysis of genomic impinting in cancerPrincipal Investigator

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ヒト21番染色体を保持するダウン症候群モデルマウスの作出とその原因遺伝子同定Principal Investigator

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Oshimura Mitsuo 押村光雄

OSHIMURA Mitsuo 押村光雄