INOUE Toshiaki 井上敏昭

Researcher Number	80305573
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2018: Tottori University, Faculty of Madicine, Associate Professor 2006: 鳥取大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Applied genomics / Genetics/Genome dynamics / Genetics/Chromosome dynamics / Basic Section 44010:Cell biology-related Except Principal Investigator Biological Sciences / Applied genomics / Biomedical engineering/Biological material science / Tumor biology / Pathological medical chemistry / Biomedical engineering/Biomaterial science and engineering / General pharmacology / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator オートファジー / SIRT2 / 人工染色体 / 紡錘体チェックポイント / 四倍体 / 細胞死 / M期停止 / p53 / 微小核 / ゲノムコピー数多型 … More Except Principal Investigator 細胞融合 / サイトカイン / SIRT2 / M期チェックポイント / 染色体異数性 / 染色体不安定性 / ヒト人工染色体 / 遺伝子発現変動 / センサーローカス / 微小核細胞 / 染色体導入 / 麻疹ウイルス / エンベロープタンパク質 / CD46 / 一本鎖抗体 / リターゲティング / 微小核 / エンベローブタンパク質 / がん制御遺伝子 / がん抑制遺伝子 / テロメレース / TERT / 細胞老化 / ヒト5番染色体 / PITX1 / 細胞内情報伝達 / 染色体ベクター / ミクロセル / 腎毒性試験 / レポーター遺伝子 / 転写制御 / ヒト腎臓培養細胞株 / 培養細胞 / 腎毒性 / IL-6遺伝子レポーター / IL-8遺伝子レポーター / 人工染色体ベクター Less

がん発症過程における炎症性サイトカインによるRBM10リン酸化の意義の解明Ongoing
- Principal Investigator
  
  小島裕正
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka City University
Mechanism of cell death in tetraploid cells generated from mitotic slippagePrincipal InvestigatorOngoing
- Principal Investigator
  
  井上敏昭
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tottori University
Rapid and easy detection of nephrotoxicity using human cultured cell lines; application of IL-6/IL-8 reporter gene
- Principal Investigator
  
  KOKURA Kenji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tottori University
ミクロセル融合を介して染色体ベクターを効率よく受容細胞に移入する技術の確立
- Principal Investigator
  
  加藤基伸
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tottori University
A novel pathway of cell death in tertaploid generated after mitotic slippagePrincipal Investigator
- Principal Investigator
  
  Toshiaki Inoue
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Tottori University
Role of STAT3 in cytokine-induced senescence and senescent cell clearance
- Principal Investigator
  
  Kojima Hirotada
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
Relationship between autophagy regulation by SIRT2 and its spindle assembly checkpoint functionPrincipal Investigator
- Principal Investigator
  
  INOUE Toshiaki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Tottori University
Construdtion of Genome moving system utilizing a chromosome as transfer unit
- Principal Investigator
  
  KATOH Motonobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tottori University
Mechanical analysis for carcinogenesis by functional studies of a novel telomerase repressor gene
- Principal Investigator
  
  KUGOH Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Tottori University
Generation of human artificial vector to allow the reproduction of gene copy number variationPrincipal Investigator
- Principal Investigator
  
  INOUE Toshiaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied genomics
- Research Institution
  Tottori University
Construction of a sensor locus for monitoring gene expression on a human artificial chromosome
- Principal Investigator
  
  KATO Motonobu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied genomics
- Research Institution
  Tottori University
新規M期チェックポイントタンパクに着目する発がんにおける染色体不安定説の検証
- Principal Investigator
  
  押村光雄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Towards establishment of higher-order of nuclear architecture analysis method by using a human artificial vectorPrincipal Investigator
- Principal Investigator
  
  INOUE Toshiaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied genomics
- Research Institution
  Tottori University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Production of a Human Cell Line with a Plant Chromosome.2018
- Author(s)
  Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M.
- Total Pages
  8
- Publisher
  Humana Press,
- ISBN
  9781493977956
- Data Source
  KAKENHI-PROJECT-18K06221
[Book] Interleukin-6 Induces Premature Senescence Involving the STAT3 and Insulin-Like Growth Factor-Binding Protein 5.2014
- Author(s)
  Kojima Hirotada, Kunimoto Hiroyuki, Inoue Toshiaki, Nakajima Koichi
- Total Pages
  8
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23570005
[Book] Aging, Cancer, and Noncancer Pathologies, Interleukin-6 Induces Premature Senescence Involving the STAT3 and Insulin-Like Growth Factor-Binding Protein 5. TUMOR DORMANCY AND CELLULAR QUIESCENCE AND SENESCENCEM.2013
- Author(s)
  Kojima H, Kunimoto H, Inoue T, Nakajima K
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23570005
[Book] 実験医学別冊「実験医学別冊培養細胞実験ハンドブック」細胞融合法2009
- Author(s)
  則兼聡子、井上敏昭、押村光雄
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116?cells with SIRT2 suppression2019
- Author(s)
  Li Y, Kokura K, Inoue T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Pages: 208-236
- DOI
  10.1016/j.bbrc.2018.11.136
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06221, KAKENHI-PROJECT-16K08548
[Journal Article] Production of a Human Cell line with a Plant Chromosome2018
- Author(s)
  Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M
- Journal Title
  
  Methods Mol Biol
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-15K07158
[Journal Article] Maintenance and Function of a Plant Chromosome in Human Cells2017
- Author(s)
  Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M
- Journal Title
  
  ACS Synth. Biol.
  
  Volume: 6 Pages: 301-310
- DOI
  10.1021/acssynbio.6b00180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07158
[Journal Article] Formation and cellular fate of micronuclei2017
- Author(s)
  Yuji nakayama, Toshiaki Inoue
- Journal Title
  
  Radiation Biology Research Communications
  
  Volume: 52 Pages: 263-276
- NAID
  40021362511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07158
[Journal Article] Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons.2016
- Author(s)
  Nakayama Y, Inoue T.
- Journal Title
  
  Molecules
  
  Volume: 21
- DOI
  10.3390/molecules21050663
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06896, KAKENHI-PROJECT-15K07158
[Journal Article] A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to biomedical challenges2015
- Author(s)
  Oshimura Mitsuo, Uno Narumi, Kazuki Yasuhiro, Katoh Motonobu, Inoue Toshiaki
- Journal Title
  
  Chromosome Res.
  
  Volume: 23 Pages: 111-133
- DOI
  10.1007/s10577-014-9459-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23570005, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-25640049, KAKENHI-PROJECT-15K01291, KAKENHI-PROJECT-15K07158
[Journal Article] Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector.2015
- Author(s)
  Narai T, Katoh M, Inoue T, Taniguchi M, Kazuki K, Kazuki Y, Sato K, Kodani I, Ryoke K, Oshimura M.
- Journal Title
  
  Yonago Acta Med.
  
  Volume: 58 Pages: 23-29
- NAID
  120005596729
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07158
[Journal Article] Construction of a luciferase reporter system to monitor osteogenic differentiation of mesenchymal stem cells by using a mammalian artificial chromosome vector.2015
- Author(s)
  Narai Takashi, Katoh Motonobu, Inoue Toshiaki, Taniguchi Makoto, Kazuki Kanako, Kazuki Yasuhiro, Sato Kenzo, Kodani Isamu, Ryoke Kazuo, Oshimura Mitsuo
- Journal Title
  
  Yonago Acta Med.
  
  Volume: 58
- NAID
  120005596729
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23570005
[Journal Article] Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector.2015
- Author(s)
  Narai T, Katoh M, Inoue T, Taniguchi M, Kazuki K, Kazuki Y, Sato K, Kodani I, Ryoke K, Oshimura M.
- Journal Title
  
  Yonago Acta Med
  
  Volume: 58 Pages: 23-29
- NAID
  120005596729
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01291
[Journal Article] Recurrent Micronucleation through Cell Cycle Progression in the Presence of Microtubule Inhibitors2015
- Author(s)
  Nakayama Yuji, Uno Narumi, Uno Katsuhiro, Mizoguchi Yamato, Komoto Shinya, Kazuki Yasuhiro, Nanba Eiji, Inoue Toshiaki, Oshimura Mitsuo
- Journal Title
  
  Cell Structure and Function
  
  Volume: 40 Issue: 1 Pages: 51-59
- DOI
  10.1247/csf.14005
- NAID
  130004885868
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23570005, KAKENHI-PROJECT-15K06896, KAKENHI-PROJECT-15K07158
[Journal Article] SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.2014
- Author(s)
  Inoue T, Nakayama Y, Li Y, Matsumori H, Takahashi H, Kojima H, Wanibuchi H, Katoh M, Oshimura M.
- Journal Title
  
  FEBS J.
  
  Volume: 11 Pages: 2623-2637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.2014
- Author(s)
  Suematsu Tomohisa, Li Yanze, Kojima Hirotada, Nakajima Koichi, Oshimura Mitsuo, Inoue Toshiaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 453 Pages: 588-594
- DOI
  10.1016/j.bbrc.2014.09.128
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23570005
[Journal Article] Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.2014
- Author(s)
  Suematsu T, Li Y, Kojima H, Nakajima K, Oshimura M, Inoue T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 3 Pages: 588-594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] Deacetylation of PGAM in its distinct central region by SIRT2 downregulates its enzymatic activity.2014
- Author(s)
  Tsusaka Takeshi, Guo Tingting, Yagura Teiti, Inoue Toshiaki, Yokode Masayuki, Inagaki Nobuya, Kondoh Hiroshi
- Journal Title
  
  Genes to Cells
  
  Volume: 19 Pages: 766-77
- DOI
  10.1111/gtc.12176
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23570005, KAKENHI-PROJECT-26310103
[Journal Article] SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.2014
- Author(s)
  Inoue Toshiaki, Nakayama Yuji, Li Yanze, Matsumori Haruka, Takahashi Haruka, Kojima Hirotada, Wanibuchi Hideki, Katoh Motonobu, Oshimura Mitsuo
- Journal Title
  
  FEBS J.
  
  Volume: 281 Pages: 2623-2637
- DOI
  10.1111/febs.12810
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23570005
[Journal Article] SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors2014
- Author(s)
  Inoue, Toshiaki; Nakayama, Yuji; Li, Yanze; Matsumori, Haruka; Takahashi, Haruka; Kojima, Hirotada; Wanibuchi, Hideki; Katoh, Motonobu; Oshimura, Mitsuo
- Journal Title
  
  FEBS J
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570005
[Journal Article] IL-6-STAT3 signaling and premature senescence.2013
- Author(s)
  Kojima H, Inoue T, Kunimoto H, Nakajima K.
- Journal Title
  
  JAKSTAT
  
  Volume: 2 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460392
[Journal Article] IL-6-STAT3 signaling and premature senescence.2013
- Author(s)
  Kojima H, Inoue T, Kunimoto H, Nakajima K
- Journal Title
  
  JAK-STAT
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570005
[Journal Article] The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts2012
- Author(s)
  Kojima H, Kunimoto H, Inoue T, Nakajima K
- Journal Title
  
  Cell Cycle
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts.2012
- Author(s)
  Kojima H, Kunimoto H, Inoue T, Nakajima K
- Journal Title
  
  Cell Cycle.
  
  Volume: 11 Pages: 132-145
- DOI
  10.4161/cc.11.4.19172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590316, KAKENHI-PROJECT-23570005
[Journal Article] Transcriptional activation of SAP97 by HSF-1 stabilizes Kv1. 5 in HL-1 cells2011
- Author(s)
  Ting Y, Morikawa K, Kurata Y, Li P, Bahrudin Udin, Miake J, Yamamoto Y, Murata M, Inoue T, Nakai A, Shiota G, Higaki K, Ninomiya H, Shirayoshi, Y, Hisatome I
- Journal Title
  
  Br J Pharmacol
  
  Volume: 162 Pages: 1832-1842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] Identification of PITX1 as a TERT suppressor gene located on human chromosome 5.2011
- Author(s)
  Qi DL, Ohhira T, Fujisaki C, Inoue T, Ohta T, Osaki M, Ohshiro E, Seko T, Aoki S, Oshimura M & Kugoh H
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 31(8) Pages: 1624-1636
- DOI
  10.1128/mcb.00470-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200038, KAKENHI-PROJECT-22501012, KAKENHI-PROJECT-23570005
[Journal Article] MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression.2011
- Author(s)
  Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, Kobayashi E, Yamada T, Kawai A, Inoue T, Ito H, Oshimura M, Ochiya T
- Journal Title
  
  Mol Ther
  
  Volume: 19(6) Pages: 1123-1130
- DOI
  10.1038/mt.2011.53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04220, KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-22390296, KAKENHI-PROJECT-23570005, KAKENHI-PROJECT-23650597
[Journal Article] Identification of PITX1 as a TERT suppressor gene located on human chromosome 52011
- Author(s)
  Qi DL, Ohhira T, Fujisaki C, Inoue T, Ohta T, Osaki M, Ohshiro E, Seko T, Aoki S, Oshimura M, Kugoh H
- Journal Title
  
  Mol Cell Biol
  
  Volume: 31 Pages: 1624-1636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] SIRT2 downregulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis2011
- Author(s)
  Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A, Ito H, Mori S, Katoh M, Oshimura M, Inoue T
- Journal Title
  
  Genes Cells
  
  Volume: 16 Pages: 34-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression2011
- Author(s)
  Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, Kobayashi E, Yamada T, Kawai A, Inoue T, Ito H, Oshimura M, Ochiya T
- Journal Title
  
  Mol. Ther
  
  Volume: 19 Pages: 1123-1130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] Cysteine-rich protein 61(CYR61) suppresses cell invasion via down-regulation of matrix metalloproteinase-7(MMP-7) expression in a human gastric carcinoma cell line, MKN-452010
- Author(s)
  Osaki M, Inaba A, Nishikawa K, Sugimoto Y, Shomori K, Inoue T, Oshimura M, Ito H
- Journal Title
  
  Mol Med Rep
  
  Volume: 3 Pages: 711-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance2009
- Author(s)
  Kai Y, Wang CC, Kishigami S, Kazuki Y, Abe S, Takiguchi M, Shirayoshi Y, Inoue T, Ito H, Wakayama T, Oshimura M
- Journal Title
  
  Cell Res
  
  Volume: 19 Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest2009
- Author(s)
  Inoue T, Nakayama Y, Yamada H, Li YC, Yamaguchi S, Osaki M, Kurimasa A, Hiratsuka M, Katoh M, Oshimura M
- Journal Title
  
  Cell Cycle
  
  Volume: 8 Pages: 1279-1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] SIRT2 downregulation confers resistance to microtubuleinhibitors by prolonging chronic mitotic arrest2009
- Author(s)
  Inoue T.
- Journal Title
  
  Cell Cycle 8
  
  Pages: 1279-1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.2009
- Author(s)
  井上敏昭
- Journal Title
  
  Cell Cycle 8
  
  Pages: 1279-1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion2008
- Author(s)
  Yamada H, Li YC, Nishikawa M, Oshimura M, Inoue T
- Journal Title
  
  J Hum Genet
  
  Volume: 53 Pages: 447-453
- NAID
  10021248965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] Functional stabilization of Kv1. 5 protein by Hsp70 in mammalian cell lines2008
- Author(s)
  Hirota Y, Kurata Y, Kato M, Notsu T, Koshida S, Inoue T, Kawata Y, Miake J, Bahrudin U, Li P, Hoshikawa Y, Yamamoto Y, Igawa O, Shirayoshi Y, Nakai A, Ninomiya H, Higaki K, Hiraoka M, Hisatome I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 372 Pages: 469-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310120
[Journal Article] The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.2007
- Author(s)
  Inoue T
- Journal Title
  
  Cell Cycle 6
  
  Pages: 1011-1018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012033
[Journal Article] The molecular biology of mammalian SIRT proteins : SIRT2 in cell cycle regulation.2007
- Author(s)
  Inoue T
- Journal Title
  
  Cell Cycle (in press)
- Data Source
  KAKENHI-PROJECT-18012033
[Journal Article] SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress2007
- Author(s)
  Inoue T
- Journal Title
  
  Oncogene 26
  
  Pages: 945-957
- Data Source
  KAKENHI-PROJECT-18012033
[Presentation] CRISPR/CASを利用した新規骨分化ハイスループットスクリーニング系の樹立2019
- Author(s)
  奈良井節、綿世諒平、井上敏昭、古倉健嗣、小谷勇
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16K08548
[Presentation] 骨分化の新規ハイスループットスクリーニング系樹立の試み2019
- Author(s)
  奈良井　節, 綿世諒平, 加藤基伸, 井上敏昭, 古倉健嗣, 小谷勇, 押村光雄
- Organizer
  第18回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-18K06221
[Presentation] マウス・ヒト細胞株を用いた簡便なin vitro腎毒性応答の検出2018
- Author(s)
  古倉健嗣、井上敏昭、安西尚彦、大林徹也
- Organizer
  第59回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K06221
[Presentation] Maintenance and Function of a Plant Chromosome in Human Cells2018
- Author(s)
  Naoki Wada, Yasuhiro Kazuki, Kanako Kazuki, Toshiaki Inoue, Keishi Osakabe, Kiichi Fukui, and Mitsuo Oshimura
- Organizer
  第59回植物生理学会
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] 生細胞で骨分化をモニタリングできるヒト間葉系幹細胞株の樹立2018
- Author(s)
  奈良井　節,　綿世諒平,　古倉健嗣,　井上敏昭,　小谷勇
- Organizer
  第65回(公社)日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K06221
[Presentation] 骨分化の新規ハイスループットスクリーニング系の樹立2018
- Author(s)
  奈良井節、綿世諒平、古倉健嗣、加藤基伸、押村光雄、井上敏昭、小谷勇
- Organizer
  第47回日本口腔外科学会中国四国支部学術集会
- Data Source
  KAKENHI-PROJECT-16K08548
[Presentation] 骨分化の新規ハイスループットスクリーニング系樹立の試み2018
- Author(s)
  奈良井節, 綿世諒平, 加藤基伸, 井上敏昭, 古倉健嗣, 小谷勇, 押村光雄
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] 骨分化の新規ハイスループットスクリーニング系樹立の試み2018
- Author(s)
  奈良井節、綿世諒平、加藤基伸、井上敏昭、古倉健嗣、小谷勇、押村光雄
- Organizer
  第59回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K06221
[Presentation] マウス・ヒト細胞株を用いた簡便なin vitro腎毒性応答の検出2018
- Author(s)
  古倉健嗣、井上敏昭、安西尚彦、大林徹也
- Organizer
  第59回日本生化学会　中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-16K08548
[Presentation] 骨分化の新規ハイスループットスクリーニング系樹立の試み2018
- Author(s)
  奈良井節、綿世諒平、加藤基伸、井上敏昭、古倉健嗣、小谷勇、押村光雄
- Organizer
  第17回再生医療学会、横浜、2018
- Data Source
  KAKENHI-PROJECT-16K08548
[Presentation] 骨分化の新規ハイスループットスクリーニング系樹立2018
- Author(s)
  奈良井　節, 綿世諒平, 古倉健嗣, 加藤基伸, 押村光雄,井上敏昭, 小谷勇
- Organizer
  第47回(公社)日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-18K06221
[Presentation] 骨分化の新規ハイスループットスクリーニング系樹立の試み2018
- Author(s)
  奈良井節、綿世諒平、加藤基伸、井上敏昭、古倉健嗣、小谷勇、押村光雄
- Organizer
  第59回日本生化学会　中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-16K08548
[Presentation] 基底オートファジーがM期停止からの細胞死を制御する機構2018
- Author(s)
  加藤芙美乃、李艶澤、井上敏昭
- Organizer
  第59回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K06221
[Presentation] ヒト間葉系幹細胞における副甲状腺ホルモンの間歇的投与による最適な骨形成条件の検索2017
- Author(s)
  奈良井　節,加藤基伸, 井上敏昭 ,小谷勇, 押村光雄, 領家和男
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] ヒトと植物細胞の部分的な細胞融合株の樹立: 進化を超えた染色体機能保存性の解明を目指して2017
- Author(s)
  和田直樹、香月康宏、香月加奈子、井上敏昭、福井希一、押村光雄
- Organizer
  第5回細胞凝集研究会（Cell Aggregation Meeting 2017）
- Invited
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] ヒト細胞における植物染色体の維持と機能2016
- Author(s)
  和田直樹、香月康宏、香月加奈子、井上敏昭、福井希一、押村光雄
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] PITX1タンパク質はhTERT発現を制御するためにZCCHC10と相互作用する2016
- Author(s)
  大平崇人、小島裕正、黒田悠子、稲岡大悟、森脇鏡后、春日健人、片岡美喜、井上敏昭、押村光雄、久郷裕之
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] 微小管阻害剤存在下における倍数体化を伴って段階的に進む微小核誘導2015
- Author(s)
  中山祐二、宇野愛海、宇野勝洋、古本真也、香月康弘、難波栄二、井上敏昭、押村光雄
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] ミクロセル融合を介した染色体ベクター移入法の改良2015
- Author(s)
  山本加奈恵、楠瀬未菜、中山祐二、井上敏昭、押村光雄、加藤基伸
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] ミクロセル融合を介した染色体ベクター移入法の改良2015
- Author(s)
  山本加奈恵、楠瀬未菜、中山祐二、井上敏明、押村光雄、加藤基伸
- Organizer
  第38回日本分子生物学会　年会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K01291
[Presentation] SIRT2によるBubR1のリジン250の脱アセチル化とBubR1の安定性に及ぼす効果2015
- Author(s)
  井上敏昭、李艶沢、久郷裕之、押村光雄
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K07158
[Presentation] Searching for target molecules for deacetylation by SIRT2 during mitotic slippage caused by microtubule inhibitors2013
- Author(s)
  Tomohisa Suematsu, Yanze Li, Mitsuo Oshimura, Toshiaki Inoue
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-23570005
[Presentation] SIRT2によるオートファジー異常亢進の抑制は微小管阻害剤処理による癌の効的な癌細胞死誘導に必要である2013
- Author(s)
  井上敏昭、李艶沢、押村光雄
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23570005
[Presentation] hTERT発現を抑制するPitX1から解き明かすhTERT発現制御ネットワーク2012
- Author(s)
  吉川なつこ, 末松知久, 大平崇人, 押村光雄, 久郷裕之, 井上敏昭
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡, 福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-22501012
[Presentation] 複数の遺伝子搭載が可能な人工染色体ベクターの構築2012
- Author(s)
  荻野由加利、中山祐二、松森はるか、田中伸幸、押村光雄、難波栄ニ、井上敏昭
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23570005
[Presentation] 複数の遺伝子搭載が可能な人工染色体ベクターの構築2011
- Author(s)
  荻野由加利、松森はるか、押村光雄、中山祐二、井上敏昭
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] がん治療の新たな標的分子としてのSIRT22011
- Author(s)
  李艶沢、末松知久、中山祐二、押村光雄、井上敏昭
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] 染色体導入による新規テロメラーゼ抑制遺伝子の同定2011
- Author(s)
  久郷裕之, Dong-Lai Qi, 大平崇人, 太田力, 井上敏昭, 押村光雄
- Organizer
  第56回日本人類遺伝学会
- Place of Presentation
  幕張, 幕張メッセ
- Data Source
  KAKENHI-PROJECT-22501012
[Presentation] 染色体導入による新規テロメレース抑制遺伝子の同定がん若手研究者ワークショップ長野アートランドホテル蓼科2011
- Author(s)
  大平崇人, Dong-Lai Qi, 藤崎央子, 井上敏昭, 太田力, 尾崎充彦, 大城恵理子, 瀬古朋美, 青木伸介, 押村光雄, 久郷裕之
- Data Source
  KAKENHI-PROJECT-22501012
[Presentation] 麻疹ウイルスエンベロープタンパク質を利用したヒト人工染色体ベクターのin vivo導入へ向けた試み2011
- Author(s)
  高橋悠, 加藤基伸, 尾崎充彦, 中山祐二, 中村貴史, 井上敏昭, 押村光雄
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22500426
[Presentation] 複数の遺伝子搭載が可能な人工染色体ベクターの構築2011
- Author(s)
  荻野由加利、松森はるか、押村光雄、中山祐二、井上敏昭
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23570005
[Presentation] 複数の遺伝子搭載が可能な人工染色体ベクターの構築2011
- Author(s)
  松森はるか、加藤基伸、中山祐二、押村光雄、井上敏昭
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都会館(京都市)
- Year and Date
  2011-03-25
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] 麻疹ウイルスエンベロープを利用した微小核細胞融合法による染色体導入2011
- Author(s)
  高橋悠、加藤基伸、香月康宏、香月加奈子、梶谷尚世、滝口正人、中山祐二、中村貴史、井上敏昭、押村光雄
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都会館(京都市)
- Year and Date
  2011-03-25
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] 麻疹ウイルスエンベロープタンパク質を利用したヒト人工染色体ベクターのin vivo導入に向けた試み2011
- Author(s)
  高橋悠、加藤基伸、尾崎充彦、中山祐二、中村貴史、井上敏昭、押村光雄
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23570005
[Presentation] がん治療の新たな標的分子としてのSIRT22011
- Author(s)
  李艶沢、末松知久、中山祐二、押村光雄、井上敏昭
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23570005
[Presentation] ヒト5 番染色体上に存在する新規テロメレース抑制遺伝子の同定.2010
- Author(s)
  久郷裕之, Dong-Lai Qi, 大平崇人, 太田力, 井上敏昭, 押村光雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22501012
[Presentation] ヒト5番染色体上に存在する新規テロメレース抑制遺伝子の同定2010
- Author(s)
  久郷裕之、Dong-Lai Qi、大平嵩人、太田力、井上敏昭、押村光雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] PITX1はTERT遺伝子の抑制調節因子の一つである2010
- Author(s)
  ong-Lai Qi, 大平崇人, 太田力, 井上敏昭, 尾崎充彦, 押村光雄, 久郷裕之
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22501012
[Presentation] Chromosome transfer via microcell fusion utilizing fusogenic envelope proteins of Measles Virus2010
- Author(s)
  Motonobu Katoh, Yasuhiro Kazuki, Haruka Takahashi, Kanako Kazuki, Naoyo Kajitani, Masato Takiguchi, Yuji Nakayama, Takafumi Nakamura, Toshiaki Inoue, Mitsuo Oshimura
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22500426
[Presentation] SIRT2発現低下によるp53依存性細胞死誘導とその機序2010
- Author(s)
  李艶沢、井上敏昭、押村光雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] Chromosome transfer via microcell fusion utilizing fusogenic envelope proteins of Measles virus2010
- Author(s)
  Motonobu Katoh, Yasihiro Kazuki, Haruka Takahashi, Kanako Kazuki, Naoyo Kajitani, Masato Takiguchi, Yuji Nakayama, Takafumi Nakamura, Toshiaki Inoue, Mitsuo Oshimura
- Organizer
  第33回日本分子生物学会第83回日本生化学会合同大会
- Place of Presentation
  神戸ポートピアアイランド(神戸市)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] SIRT2発現低下による微小管阻害剤耐性獲得とその分子機構2009
- Author(s)
  李艶沢、押村光雄、井上敏昭
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] 人工染色体システムを用いたトリプレットリピート解析系の構築2008
- Author(s)
  中山祐二、井上敏昭、押村光雄、難波栄二
- Organizer
  第53回日本人類遺伝学会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2008-09-27
- Data Source
  KAKENHI-PROJECT-20310120
[Presentation] mitosis制御におけるSIRT2の役割2007
- Author(s)
  井上敏昭
- Organizer
  第30会日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18012033
[Presentation] オートファジー制御による四倍体からの細胞死誘導経路
- Author(s)
  足立美保子、末松知久、押村光雄、井上敏昭
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-23570005

1. KATO Motonobu (00273904)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
2. KOKURA Kenji (30344039)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. OHBAYASHI Tetsuya (80348804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Kojima Hirotada (40336772)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. NANBA Eiji (40237631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKEYA Hiroyuki (60222105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KUGOH Hiroyuki (40225131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. MATSUDA Ken-ichi (40315932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 押村光雄 (20111619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 平塚正治 (00362872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中嶋弘一 (00227787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 中山祐二 (40432603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. OHHIRA Takahito

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. SUNAMURA Naohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Li Yanze

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KONDOH Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 難波栄二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 竹下文隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 川井章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 落谷孝広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 尾崎充彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 井藤久雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 横出正之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE Toshiaki 井上 敏昭

Research Projects

Research Products

Co-Researchers

がん発症過程における炎症性サイトカインによるRBM10リン酸化の意義の解明Ongoing

Principal Investigator

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Mechanism of cell death in tetraploid cells generated from mitotic slippagePrincipal InvestigatorOngoing

Principal Investigator

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Review Section

Research Institution

Rapid and easy detection of nephrotoxicity using human cultured cell lines; application of IL-6/IL-8 reporter gene

Principal Investigator

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Research Institution

ミクロセル融合を介して染色体ベクターを効率よく受容細胞に移入する技術の確立

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

A novel pathway of cell death in tertaploid generated after mitotic slippagePrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Role of STAT3 in cytokine-induced senescence and senescent cell clearance

Principal Investigator

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Relationship between autophagy regulation by SIRT2 and its spindle assembly checkpoint functionPrincipal Investigator

Principal Investigator

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Research Institution

Construdtion of Genome moving system utilizing a chromosome as transfer unit

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Mechanical analysis for carcinogenesis by functional studies of a novel telomerase repressor gene

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Generation of human artificial vector to allow the reproduction of gene copy number variationPrincipal Investigator

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Construction of a sensor locus for monitoring gene expression on a human artificial chromosome

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新規M期チェックポイントタンパクに着目する発がんにおける染色体不安定説の検証

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Towards establishment of higher-order of nuclear architecture analysis method by using a human artificial vectorPrincipal Investigator

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INOUE Toshiaki 井上敏昭