Yamada Mitsunori 山田光則

… Alternative Names

Researcher Number	30240039
Other IDs
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Affiliation (Current)	2019: 信州大学, 医学部, 特任教授 2019: 独立行政法人国立病院機構さいがた医療センター(臨床研究部), 臨床研究部, 臨床研究部長
Affiliation (based on the past Project Information) *help	2016 – 2019: 信州大学, 医学部, 特任教授 2011: 独立行政法人国立病院機構, さいがた病院・検査部, 部長 2009: 新潟大, 脳研究所, 准教授 2007 – 2008: Niigata University, Brain Research Ins, Associate Professor 2000 – 2006: 新潟大学, 脳研究所, 助教授 … More
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Biological Sciences / Nerve anatomy/Neuropathology Except Principal Investigator Neuroscience in general / Nerve anatomy/Neuropathology / Pediatrics / Human pathology / Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology / Neurology / Cerebral neurosurgery
Keywords	Principal Investigator ポリグルタミン病 / 病理 / 遺伝子発現 / 病理学 / 脳神経疾患 / 動物実験 / 細胞計測 / 痴呆 / 下オリーブ核肥大 / ポリグルタミン … More Except Principal Investigator subventricular zone / CD38 / Immunohistochemistry / 蛍光分子 / 免疫組織化学 / グリア芽細胞 / レトロウィルス / 中枢神経系 / Astrocyte / 1C2 / アストロサイト / Cyclic ADP-ribose / 脊髄小脳変性症 / Balo desease / tangential migration / 多発性硬化症 / 細胞死 / Central nervous system / 神経病理 / ポリグルタミン病 / Spinocerebellar ataxia / シナプス小胞 / Eastern Europeans / リポオリゴ糖 / イノシトール三リン酸 / 色素性乾皮症 / Subventricular zone / fluorescent labeling / Cell death / 青斑核 / ウエスタンブロッティング / 病巣修復 / フィッシャー症候群 / 民族の遺伝子 / 小脳変性症 / Two-dimensional electrophoresis / 脳内未分化細胞 / Calcium ion / 脱髄性脳疾患 / Repair process / lipo-oligosaccharide / retrovirus / メラニン含有神経細胞 / ウェスタンブロッティング / 神経芽細胞 / 加齢 / Fate determination / Racial Genes / Campylobacter jejuni / 脳浮腫 / コケイン症候群 / animal model / Glial progenitor / 同心円硬化症 / 動物モデル / 胎児脳 / Haemophilus influenzae / Cockayne's syndrome / Nerve growth factor / glial progenitor / 神経成長因子 / Concentric Sclerosis / リポ多糖 / Brain stem cells / グリア封入体 / Brain edema / Retrovirus / 剖検例 / 二次メッセンジャー / 2次元電気泳動 / シナプス終末 / パーキンソン病 / 移動動態 / corpus callosum / Fluorescent molecule / 自己免疫疾患 / 分化決定 / 分子相同性 / 可溶性タンパク質 / 胎児脳病巣 / Astrocytosis / 黒質 / カルシウムイオン / 細胞移動 / molecular mimicry / CSF1R / Autopsy Cases / knockout mouse / 腫大軸索 / ノックアウト / 症例対照試験 / radial fiber / Xeroderma pigmentosum / polyglutamine diseases / Fetal brain / Neuropathology / 細胞内情報伝達 / 白質脳症 / 神経発生 / Western blotting / Central nervous System / イノシトールリン脂質 / 脳画像 / Fetal brain lesion / 未分化細胞 / アミノ酸配列 / autoimmune disease / Balo病 / Neural development / Inositol 1,4,5-trisphosphate / 未分化細部 / amino acid sequence / Multiple Sclerosis / ギラン・バレー症候群 / Neuronal progenitor / Demyelinating desease / グリア / 東欧諸国 / 疾患モデル / non-radial migration / 肝性脳症 / 神経伝達物質放出 / Guillain-Barre syndrome / Second messenger / ノックアウトマウス / サイクリックADPリボース / Migratory behavior / Hepatic encephalopathy Less

Hereditary leukoencephalopathy with axonal spheroids: CSF1R positive cells and lesion staging based on brain imageOngoing
- Principal Investigator
  
  小柳清光
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shinshu University
多系統萎縮症のステージ分類確立：グリア封入体を基盤とする分子病理学的解析Principal InvestigatorOngoing
- Principal Investigator
  
  山田光則
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shinshu University
Regulation of synaptic vesicle exocytosis by soluble proteins
- Principal Investigator
  
  ABE Teruo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
ポリグルタミン病の細胞骨格変異に関する分子病態の解明Principal Investigator
- Principal Investigator
  
  山田光則
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Atherapeutic approach to polyglutamine diseases by the activation of cellularproteolyticpathwaysPrincipal Investigator
- Principal Investigator
  
  YAMADA Mitsunori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
歯状核赤核淡蒼球ルイ体萎縮症モデルマウスにおける脳萎縮の病態解明Principal Investigator
- Principal Investigator
  
  山田光則
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
New polyglutamine diseases : from the neuropathologies to the identification of genes responsible for the diseases
- Principal Investigator
  
  TAKAHASHI Hitoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Niigata University
ポリグルタミン病におけるリソゾーム蛋白質分解系の病態解析Principal Investigator
- Principal Investigator
  
  山田光則
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
Pathogenesis of Guillain-Barre syndrome and Fisher syndromes : evidence of molecular mimicry
- Principal Investigator
  
  YUKI Nobuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Dokkyo University School of Medicine
Molecular mechanism of mutant protein degradation in polyglutamine diseasePrincipal Investigator
- Principal Investigator
  
  YAMADA Mitsunori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  NIIGATA UNIVERSITY
Migration pathways and fate determination of progenitors in the subventricular zone
- Principal Investigator
  
  KAKITA Akiyoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  NIIGATA UNIVERSITY
Investigation on migration mechanisms of glial progenitors: observations of living cells labeled by dual fluorescent molecules
- Principal Investigator
  
  KAKITA Akiyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Niigata University
Histopathological study on neurodegeneration in the mouse model of xeroderma pigmentosum and Cockayne's syndrome
- Principal Investigator
  
  TAKAHASHI Hitoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
ヒトの黒質・青斑核メラニン含有神経細胞体に陥入して存在するシナプスの生物学的意義
- Principal Investigator
  
  TAKAHASHI Hitoshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Studies on demyelinating disease in the Eastern Europeans
- Principal Investigator
  
  TAKAHASHI Hitoshi, 生田房弘
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Niigata University
痴呆の病態病理:神経細胞樹状突起棘の情報伝達系機能分子に関する細胞病理学的研究Principal Investigator
- Principal Investigator
  
  山田光則
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Distribution and function of phosphoinositide second messenger system in developing brain
- Principal Investigator
  
  MIZUGUCHI Masashi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Institute of Neuroscience, NCNP
Cell biology on the process of brain lesion repair and the fetal brain development
- Principal Investigator
  
  IKUTA Fusahiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Niigata University

All 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Animal model of DRPLA2008
- Author(s)
  Yamada, M., et. al.
- Journal Title
  
  Neurol Med 23
  
  Pages: 2408-2415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] 動物モデルからみた歯状核赤核淡蒼球ルイ体萎縮症.2008
- Author(s)
  山田光則
- Journal Title
  
  神経内科 68
  
  Pages: 135-139
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] 動物モデルからみた歯状核赤核淡蒼球ルイ体萎縮症.2008
- Author(s)
  山田光則
- Journal Title
  
  神経内科 68
  
  Pages: 135-139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] CAG repeat disorder models and human neuropathology: similarities and differences.2008
- Author(s)
  Yamada, M., et. al.
- Journal Title
  
  Acta Neuropathol 115
  
  Pages: 71-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] CAG repeat disorder models and human neuropathology: similarities and differences.2008
- Author(s)
  Yamada M
- Journal Title
  
  Acta Neuropathol 115
  
  Pages: 71-86
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] DRPLA2007
- Author(s)
  Yamada, M., et. al.
- Journal Title
  
  Clin Neurosci 25
  
  Pages: 850-851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] DRPLA.2007
- Author(s)
  山田光則
- Journal Title
  
  Clinical Neuroscience 25
  
  Pages: 850-851
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] DRPLA2007
- Author(s)
  山田光則
- Journal Title
  
  Clinical Neuroscience 25
  
  Pages: 850-851
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] Polyglutamine disease: Recent advances in the neuropathology of dentatorubral-pallidoluysian atrophy.2006
- Author(s)
  Yamada M
- Journal Title
  
  Neuropathology 26
  
  Pages: 346-351
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] Polyglutamine disease: Recent advances in the neuropathology of dentatorubral-pallidoluysian atrophy2006
- Author(s)
  Yamada, M., et. al.
- Journal Title
  
  Neuropathology 26
  
  Pages: 346-351
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリグルタミン病の分子病態機序2006
- Author(s)
  山田光則
- Journal Title
  
  神経進歩 50
  
  Pages: 439-448
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリグルタミン病の分子病態機序.2006
- Author(s)
  山田光則
- Journal Title
  
  神経進歩 50
  
  Pages: 439-448
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリグルタミン病の分子病態機構2006
- Author(s)
  山田光則
- Journal Title
  
  神経進歩 50(印刷中)
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] Polyglutamine disease : recent advances in the neuropathology of DRPLA2006
- Author(s)
  M.Yamada
- Journal Title
  
  Neuropathology 26(In press)
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] Polyglutamine disease : Recent advances in the neuropathology of dentatorubral-pallidoluysian atrophy.2006
- Author(s)
  Yamada M
- Journal Title
  
  Neuropathology 26
  
  Pages: 346-351
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] Molecular mechanism of polyglutamine disease2005
- Author(s)
  Yamada, M., et. al.
- Journal Title
  
  Shinkei Kenkyu no Shinpo 23
  
  Pages: 2408-2415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリグルタミン病における神経細胞変性機構2005
- Author(s)
  山田光則
- Journal Title
  
  実験医学 23
  
  Pages: 2408-2415
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] Mechanism of neuronal degeneration in polyglutamine disease2005
- Author(s)
  Yamada, M., et. al.
- Journal Title
  
  Exp Med 23
  
  Pages: 2408-2415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリグルタミン病における神経細胞変性機構2005
- Author(s)
  山田光則
- Journal Title
  
  実験医学 23・15
  
  Pages: 198-205
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリグルタミン病における神経細胞変性機構.2005
- Author(s)
  山田光則
- Journal Title
  
  実験医学 23
  
  Pages: 2408-2415
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Journal Article] ポリダルタミン病における神経細胞変性機構2005
- Author(s)
  山田光則
- Journal Title
  
  実験医学 23
  
  Pages: 2408-2415
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] Sharing of polyglutamine localization by the neuronal nucleus and cytoplasm in CAG-repeat diseases.2004
- Author(s)
  Yamada M, Tan C-F, Inenaga C, Tsuji S, Takahashi H
- Journal Title
  
  Neuropathol Appl Neurobiol 30
  
  Pages: 665-675
- Data Source
  KAKENHI-PROJECT-16015241
[Journal Article] Sharing of polyglutamine localization by the neuronal nucleus and cytoplasm in CAG-repeat diseases.2004
- Author(s)
  Yamada M
- Journal Title
  
  Neuropathol Appl Neurobiol 30
  
  Pages: 665-675
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] ポリグルタミン病の分子病態機構
- Author(s)
  山田光則
- Journal Title
  
  神経研究の進歩 (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] Polyglutamine disease : recent advances in the neuropathology of DRPLA.
- Author(s)
  Yamada M
- Journal Title
  
  Neuropathology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390104
[Journal Article] Polyglutamine disease : recent advances in the neuropathology of DRPLA
- Author(s)
  M.Yamada
- Journal Title
  
  Neuropathology (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390104
[Presentation] 歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)モデルマウスにおけるポリグルタミン鎖長依存性の病理組織変化2008
- Author(s)
  山田光則
- Organizer
  日本神経病理学会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20500321
[Presentation] Neuropathology of a patient with Machado-Joseph disease carrying short CAG-repeat expansion2007
- Author(s)
  Yamada, M., et. al.
- Organizer
  Annual meeting of the Japanese society of neuropathology
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Presentation] The fate of neurons under the polyglutamine pathogenesis in DRPLA2006
- Author(s)
  Yamada, M., et. al.
- Organizer
  Annual meeting of the Japanese society of neuropathology
- Place of Presentation
  Okayama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Presentation] Polyglutamine disease: recent advances in the neuropathology of DRPLA2005
- Author(s)
  Yamada, M., et. al.
- Organizer
  Annual meeting of the Japanese society of neuropathology
- Place of Presentation
  Utsunomiya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Presentation] ポリグルタミン病:DRPLAを中心として2005
- Author(s)
  山田光則
- Organizer
  日本神経病理学会
- Place of Presentation
  宇都宮
- Year and Date
  2005-05-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Presentation] ポリグルタミン病における選択的細胞死:歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)モデルマウスの解析2005
- Author(s)
  山田光則
- Organizer
  日本神経病理学会
- Place of Presentation
  岡山
- Year and Date
  2005-05-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109
[Presentation] Machado-Joseph病:CAGリピート短伸長例の脳病変2005
- Author(s)
  山田光則
- Organizer
  日本神経病理学会
- Place of Presentation
  東京
- Year and Date
  2005-05-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300109

1. TAKAHASHI Hitoshi (90206839)

# of Collaborated Projects: 13 results

# of Collaborated Products: 1 results
2. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. WAKABAYASHI Kouichi (50240768)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. IKUTA Fusahiro (20018592)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OYANAGI Kiyomitsu (00134958)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. ONODERA Osamu (20303167)

# of Collaborated Projects: 2 results

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7. 武田茂樹 (90134957)

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# of Collaborated Products: 0 results
8. ABE Teruo (50010103)

# of Collaborated Projects: 1 results

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9. YAO Hiromu (00144353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FURUKAWA Shoei (90159129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIZUGUCHI Masashi (20209753)

# of Collaborated Projects: 1 results

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12. YUKI Nobuhiro (60285913)

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13. UEDA Syuichi (60150570)

# of Collaborated Projects: 1 results

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14. KOBATA Tetsuji (10205445)

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15. TOYOSHIMA Yasuko (20334675)

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16. 大浜栄作 (50018892)

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17. 吉田邦広 (90242693)

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18. JIRASEK Adam

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19. RADU Loan

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20. HEGEDUS Katalin

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21. MAJTENYI Kathrine

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22. GUSEO Andras

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23. MOSSAKOWSKI ミロストウ

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24. MOSSAKOWSKI Mirostaw j.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. JIRASEKL Ada

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KOMOLY Samue

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KUNTAR Lajos

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamada Mitsunori 山田 光則

山田 光則 ヤマダ ミツノリ

YAMADA Mitsunori 山田 光則

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Hereditary leukoencephalopathy with axonal spheroids: CSF1R positive cells and lesion staging based on brain imageOngoing

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多系統萎縮症のステージ分類確立：グリア封入体を基盤とする分子病理学的解析Principal InvestigatorOngoing

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ポリグルタミン病の細胞骨格変異に関する分子病態の解明Principal Investigator

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Atherapeutic approach to polyglutamine diseases by the activation of cellularproteolyticpathwaysPrincipal Investigator

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歯状核赤核淡蒼球ルイ体萎縮症モデルマウスにおける脳萎縮の病態解明Principal Investigator

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ポリグルタミン病におけるリソゾーム蛋白質分解系の病態解析Principal Investigator

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Molecular mechanism of mutant protein degradation in polyglutamine diseasePrincipal Investigator

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Yamada Mitsunori 山田光則

山田光則ヤマダミツノリ

YAMADA Mitsunori 山田光則