NARA Toshifumi 奈良敏文

Researcher Number	30241350
Other IDs
Affiliation (Current)	2025: 松山大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2011 – 2012: 松山大学, 薬学部, 准教授 2009: 松山大学, 薬学部, 准教授 1998 – 2004: 北海道大学, 大学院・薬学研究科, 助手 2002: Hokkaido Univ., Grad. School of Pharm Sci., Assis. Prof., 薬学研究科, 助手 1999: 北大, 薬学研究科, 助手 1994 – 1997: Hokkaido University, Faculty of Pharmaceutical Sciences, Instructor, 薬学部, 助手 1993: 北海道大学, 薬学部, 教務職員
Review Section/Research Field	Principal Investigator Biophysics / Physical pharmacy Except Principal Investigator Physical pharmacy / Physical pharmacy / Environmental pharmacy / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator PEPT1 / 多剤排出輸送担体 / 大腸菌 / 多剤耐性 / 大量発現 / 高度好塩菌 / 古細菌 / chemical modification / efflux / up take … More / electrophysiology / stable expression / dipeptide / multidrug transporter / ANS / Caco-2 / 蛍光化合物 / ドラッグデリバリー / モノカルボン酸輸送担体 / ジペプチド輸送担体 / 消化管吸収 / 基質認識 / 二次性能動輸送 / 化学修飾 / 電気生理学 / 安定発現細胞 / ジペプチド / SH試薬 / 高次構造解析 / 発現調節タンパク質 / 16SrRNA / クローニング / 腸内連鎖球菌 / 多剤排出タンパク質 / 分裂酵母 / レチナ-ルタンパク質 / レチーナールタンパク … More Except Principal Investigator Haloferax volcanii / 高度好塩菌 / ロ-ダミン123 / Enterococcus hirae / Natronobacterium pharaonis / バクテリオロドプシン / 走光性 / 微生物ロドプシン / フォトサイクル / レチナールタンパク / フォボロドプシン / センソリーロドプシン / archaeal rhodopsin / レチナール / SVD / CFU / S / UVC / pharaonis phoborhodopsin / 吸収波長 / ファラオニスフォボロドプシン / PEPT1 / 多剤排出輸送体 / Caco-2 / 抗ガン剤 / グルコース / ドキソルビシン / P-glycoprotein / 光化学中間体 / ヒドロキシルアミン / 等温滴定型熱量計 / ホトサイクル / ハロロドプシン / リポソーム / リポソームカラム / metabolic stress / Corynebacterium glutamicum / 多剤耐性 / P-糖タンパク / Photo-taxis / Isothermal titration Calorimetry / Transparent electrode / Retinal / Halobacteria / Sensory rhodopson / Phoborhodopsn / Microbial rhodopson / Natronobacterium / Natronomus pharaonis / トランスジューサー / sensory rhodopsin / 古細菌ロドプシン / HtrII / phoborhodopsin / Natronomonas pharaconis / FTIR / ITC / トランスジューサ / 透明電極 / retinal protein / color regulation / bacteriorhodopsin / flash photolysis / halobacterial transducer / photocycle / 呼吸波長 / 膜タンパク構造維持 / Halobacterium halobium / 膜タンパク安定性 / 固体NMR / バクテリオロドプシ / 波長制御 / Archaeal rhodopsin / アーカエアルロドプシン / ハロバクテリアルトランスジューサ / DNA damage / Hemoglobin / D treatment / Heat treatment of virus / UV-irradiation / parvovirus / 血液凝固第8因子 / B19 / 一重項酸素 / 血液凝固第VIII因子 / 6-4付加体 / ピリミジンダイマー / 活性酸素 / メチレンブルー / カテキン / ヒトパルボウイルスB19 / DNA障害 / ヘモグロビン / D法 / ウイルスの熱処理 / 紫外線照射 / パルボウイルス / schiff base / the decay rate of photo-intermediate / M-intermediate / absorption wavelength / bacteriorhodosin / expression system / 分子動力学計算 / 大腸菌での発現系 / ph測定 / プロトンの移動 / 発現系の構築 / シッフ塩基 / 光化学中間体の崩壊の速度 / M中間体 / バクテリオバクテリオロドプシン / 発現系 / hexokinase / glucose / ethidium / doxorubicin / Bacillus subtilis / Enteroccus hirae / ABC super family / 大腸菌 / EmrE / Halobacterium volcaii / PCR / ATP binding casette(ABC) / ABC transporter / MDR(multi-drug resistance) / Thermus thermophilus / ヘキソキナーゼ / エチジュウム / 枯草菌Bacillus subtilis / 腸内連鎖球菌Enterococcus hirae / ABCスーパーファミリー / 高度好塩菌Haloferax volcanii / anti-cancer drugs / multi-efflux transporter / methoxylate / fluorescent substrate / Peptide transporter / フローレセッイン / ピレン / 平面脂質二分子膜 / リゾリン脂質 / 膜輸送 / 腸管吸収 / ザルコシン / Sw620 / Caco2 / FITC / ダイペプチド / 蛍光性輸送基質 / メトキサレート / 蛍光生輸送基質 / ペプチドトランスポータ / Glucose / Fructose / Phodamine 123 / Anti-cancer reagents / Multi-drug resistance / プロベネシド / フルクトース / Ca-拮抗剤 / P-glycoprotein(Pgp) / 抗ガン剤排出タンパク / Escherichia coli / フラクトース / Haloarcular marismortui / N中間体 / ラマンスペクトル / Halobacterium salinarum / Natronomonas pharaonis / レチナールタンパク質 / ロドプシン / カサノリ / ブリーチ / レチナール異性化 / ホトサイクルヒロロキシルアミン / ホボロドプシン / C1イオン結合 / 卵母細胞 / 3量体形成 / ハロロドプシン(halorhodopsin) / Natronomonaa pharaonis / Clイオン結合 / フラッシュフォトリシス / イオンポンプ / halorhodopsin / Natronomonas Pharaonis / 解離定数 / MALDI-TOF / dodecy1-β-D-maltoside / C1輸送 / Circular Dichroism / exciton-coupling / 閃光光分解 / オーサイト / がん / 制御蛋白 / STAT3 / シグナル伝達 / サイトカイン / 脱着速度定数 / 吸着速度定数 / 溶離パターン / アビジン・ビオチン / 高速液体クロマトグラフィ / 膜ベジクル固定化 / 脂溶性イオン / lipophilic phosphonium cation / 溶離曲線の広がり / 溶離プロファイル / HPLC / カラムクロマトグラフ / 脂溶性フォスフォニウムイオン / 滴定型カロリメトリー / エントロピー / エンタルピー / 溶離曲線の分散 / NMR / tetraphenylboron / tetraphenylphosphonium / 疎水性相互作用 / 吸着の熱力学量 / 滴定型熱量計 / ATP駆動薬物排出ポンプ / 多剤排出 / カタボライト抑制 / グルコース効果 / 薬物排出輸送体 Less

photochemistry of sensory rhodopsin
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
  Matsuyama University
Elucidation of Cl--pumping mechanism and significance of trimer formation of halorhodopsin
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
サイトカインシグナル伝達系におけるSTAT3制御蛋白の役割
- Principal Investigator
  
  松田正
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Signal transduction via membrane protein complex : photo-signal transduction of Halobacterium salinarum
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
リポソームカラムによる脂質膜と薬物の相互作用の解析法の開発
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Biophysical Chemistry on photobrhodopsin, a sensor for a negative taxis of Halobacterium
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Application of a nutrient transporter for the drug delivery.Principal Investigator
- Principal Investigator
  
  NARA Toshifumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
脂溶性薬物の脂質2分子膜への吸着は「非古典的疎性水相互作用」か?
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Physical and/or Chemical Methods for the Removal of Virus from Transfusion Blood
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
大腸菌の多剤排出系EmrEの分子機構解明Principal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
PHYSICO-CHEMICAL STUDY ON PHARAONIS PHOBORHODOPSIN USING ITS RECOMBINANT PROTEIN
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
腸内連鎖球菌に存在するATP駆動型多剤排出輸送担体の機能解析Principal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
バクテリアにおけるATP駆動薬剤排出トランスポータに関する研究
- Principal Investigator
  
  加茂直樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ファラオニスフォボロドプシン光サイクルの分子機構の解明:大量発現系の確立を通してPrincipal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
Physicochemical Studies on multi-drug Efflux Transporters of Bacteria
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
バクテリアにおけるATP駆動薬剤排出トランスポータに関する研究
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ファラオニスフォボロドプシン光サイクルの分子機構の解明:大量発現系の確立を通してPrincipal Investigator
- Principal Investigator
  
  奈良敏文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
Drug Delivery System Utilizing Transporters That Recognize Substrates of Relatively Large Molecular Sizes
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Study on membrane transport of halobacterial cells used as model cells for the transport investigation of pharmaceutical agents
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University

All 2013 2012 2011 2010 2007

All Journal Article Presentation

[Journal Article] Thermodynamic parameters of anionbinding to halorhodopsin from Natronomonas pharaonis by isothermal titration calorimetry2013
- Author(s)
  Hayasi Saori, Tamogami Jun, Kikukawa Takashi, Okamoto Haruka, Shimono Kazumi, Miyauchi Seiji, Demura Makoto, Nara To shifumiKamo Naoki
- Journal Title
  
  Biophysical Chemistry
  
  Volume: 172巻 Pages: 61-6710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049
[Journal Article] Photo-induced bleaching of sensory rhodopsin II (phoborhodopsin) from Halobaterium salinarum by hydroxylamine: Identification of the responsible intermediates.2012
- Author(s)
  Tamogami Jun, Kikukawa Takashi, IkedaYoichi, Demura Makoto, NaraToshifumi , KamoNaoki
- Journal Title
  
  Journal of Photochemistry and Photobiology B-Biology
  
  Volume: 106巻 Pages: 87-9410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049
[Journal Article] Photoinduced proton release in proteorhodopsin at low pH: The possibility of a decrease in the pKa of Asp2272012
- Author(s)
  Tamogami Jun, Kikukawa Takashi, NaraToshifumi , Shimono Kazumi, Demura Makoto, Kamo Naoki
- Journal Title
  
  Biochemistry
  
  Volume: 51巻 Issue: 46 Pages: 9290-9301
- DOI
  10.1021/bi300940p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23657096, KAKENHI-PROJECT-23790060
[Journal Article] Anti-parallel membrane topology of two components of EbrAB, a multidrug transporter2007
- Author(s)
  T. Kikukawa, S. Miyauchi, T. Araiso, N. Kamo, T. Nara
- Journal Title
  
  Biochem. Biophys. Res. Commun. 358
  
  Pages: 1071-1075
- NAID
  120000967947
- Data Source
  KAKENHI-PROJECT-19390009
[Journal Article] Anti-parallel membrane topology of a homo-dimeric multidrug transporter, EmrE.2007
- Author(s)
  T. Nara, T. Kouyama, Y. Kurata, T. Kikukawa, S. Miyauchi, N. Kamo
- Journal Title
  
  J. Biochem. 142
  
  Pages: 621-625
- NAID
  10020095644
- Data Source
  KAKENHI-PROJECT-19390009
[Presentation] The role of chloride in the photo-induced proton transfer in sensory rhodopsin II from Natronomonas pharaoni2012
- Author(s)
  Tamogami, J., Iwano, K., Matsuyama, A., Kikukawa, T., Demura, M., Shimono, K., Nara, T. , Kamo , N
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学(名古屋市)
- Year and Date
  2012-09-23
- Data Source
  KAKENHI-PROJECT-22590049
[Presentation] 海洋細菌由来のロドプシン様タンパク質プロテオロドプシンの低pH条件下における速いプロトン放出機構2011
- Author(s)
  田母神淳、菊川峰志,下野和実,奈良敏文,宗行英朗,加茂直樹
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590049
[Presentation] Laser flash analysis of functional interaction between sensory rhodopsin NpSRII (ppR) and eubacterial chemoreceptor Tsr in E. coli2010
- Author(s)
  奈良敏文、菊川峰志、田母神淳、加茂直樹
- Organizer
  第48回日本生物物理学会
- Place of Presentation
  東北大学(仙台市)
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22590049
[Presentation] 負の走光性レセプターNpSRIIと大腸菌走化性レセプターTsrの機能的相互作用2010
- Author(s)
  奈良敏文
- Organizer
  日本生物物理学会
- Place of Presentation
  東北大学川内北キャンパス
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22590049

1. KAMO Naoki (10001976)

# of Collaborated Projects: 13 results

# of Collaborated Products: 8 results
2. MIYAUCHI Seiji (30202352)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
3. SUMI Masato (30281819)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. KIKUKAWA Takashi (20281842)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SHUTOH Satoru (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MATUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松田正 (20212219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平敬宏 (70197036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Tohru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AZUMA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IKEDA Hisami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIRAYAMA Junichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ABE Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 阿部秀樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 池淵研二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NARA Toshifumi 奈良 敏文

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大腸菌の多剤排出系EmrEの分子機構解明Principal Investigator

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NARA Toshifumi 奈良敏文