• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Azuma Nobuyoshi  東 信良

ORCIDConnect your ORCID iD *help
… Alternative Names

AZUMA Nobuyoshi  東 信良

東 信良  アズマ ノブヨシ

Less
Researcher Number 30250559
Other IDs
Affiliation (Current) 2025: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2012 – 2025: 旭川医科大学, 医学部, 教授
2001 – 2006: Asahikawa Medical University Associate Professor, 医学部, 講師
2000: 旭川医科大学, 医学部, 助手
1997: 旭川医大, 医学部, 助手
1994: 旭川医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 55030:Cardiovascular surgery-related / General surgery / Cardiovascular surgery / Thoracic surgery / General surgery
Except Principal Investigator
General surgery / Basic Section 55030:Cardiovascular surgery-related / Cardiovascular surgery / Biomedical engineering/Biological material science
Keywords
Principal Investigator
内膜肥厚 / グラフト狭窄 / 静脈グラフト / マイクロRNA / ICAM-1 / HVJ / 末梢動脈疾患 / 生活習慣病 / 酸化ストレス / 下肢閉塞性動脈硬化症 … More / Stanford type A / Acute Aortic Dissection / 家族性発症 / 急性大動脈解離 / 冠動脈バイパス / 下肢末梢動脈バイパス / 閉塞性動脈硬化症 / 血行再建 / 血管内皮前駆細胞 / 幹細胞機能 / 生命予後 / Nuclear Factor kappa B (NFkB) / decoy / graft stenosis / intimal hyperplasia / vein graft / HGF / 遺伝子治療 / デコイ / NFkB / バイパス手術 / 炎症性ストレス / 静脈内皮機能 / 静脈グラフト内膜肥厚 / 末梢動脈バイパス術 / 参加ストレス / 動脈硬化症 / 末梢動脈バイパス / 重症下肢虚血 / 静脈グラフト閉塞 / 末梢動脈血行再建 / エクソソーム / バイオマーカー / 静脈グラフト狭窄 / 下肢血行再建 / 静脈機能 / エピジェネティクス / 内皮細胞機能障害 / 内皮機能 / 血管内皮細胞 / PAI-1 / 静脈血栓症 / 長寿遺伝子 / 内皮細胞老化 / 静脈内皮細胞 / 内皮細胞 / 拒絶反応 / FK506 / 免疫制御 / 同種血管移植 / 同種動脈移植 … More
Except Principal Investigator
vein graft / decoy / p38 / intimal hyperplasia / 内膜肥厚 / HVJ / 診療実態調査 / NCDデータ / 診療データベース / ステントグラフト治療 / 外科手術 / 実態調査 / レジストリ研究 / 治療成績 / データベース / 全国規模レジストリ / 外科治療 / JCVSD / NCD / 外科治療成績 / NCD/JCVSD / 危険因子 / 手術死亡率 / 全国規模実態調査 / 全国規模データベース / 急性大動脈解離 / 血行再建術 / 下肢末梢動脈疾患 / 抑うつ状態 / フレイル / 認知症 / サルコペニア / 下肢血行再建 / 歩行機能 / 末梢動脈疾患 / 骨格筋 / limb function / polyvascular disease / critical limb ischemia / 下肢筋 / 下肢フレイルティ / 下肢虚血 / revascularization / sarcopenia / frailty / 下肢慢性虚血 / NFkB decoy / MAP kinase / Nuclear Factor Kappa B (NFkB) / graft stenosis / 細胞遊走 / ずり応力 / shear stress / mitogen-activated protein kinase / 炎症性サイトカイン / NFkB / 静脈グラフト / HCG / decellularized graft / alloeraft / gene transfer / hybrid artificial graft / small caliber proshteses / 平滑筋細胞 / hepatocyte growth factor / 小口径 / 人工血管 / HGF(肝細胞増殖因子) / 肝細胞増殖因子HGF / 内皮細胞 / 血管新生 / HGF / 脱細胞化 / 同種動脈グラフト / 遺伝子導入 / ハイブリッド人工血管 / 小口径人工血管 / aging / proliferation activity / vascular smooth muscle cell / endothelial cell / animal species / 中膜平滑筋細胞 / 老化 / 細胞増殖能 / 内膜平滑筋細胞 / 血管内皮細胞 / 動物種 Less
  • Research Projects

    (13 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (30 People)
  •  Establishing the clinical picture of non-syndromic familial type acute aortic dissection and investigating the genetic backgroundPrincipal Investigator

    • Principal Investigator
      東 信良
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Asahikawa Medical College
  •  Establishment of an animal method for controlling vein graft intimal thickening based on genetic analysis of clinical specimensPrincipal Investigator

    • Principal Investigator
      東 信良
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Asahikawa Medical College
  •  A nationwide survey of surgical treatment for acute aortic dissection using NCD data

    • Principal Investigator
      Ogino Hitoshi
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Tokyo Medical University
  •  Clinical study of stem cell function in patients with peripheral arterial disease: Role of stem cell senescence in poor prognosis of patients.Principal Investigator

    • Principal Investigator
      Nobuyoshi Azuma
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Asahikawa Medical College
  •  To analyze micro RNA derived from the dysfunctional skeletal muscle due to the ischemic limb for predicting limb functional prognosis after revascularization

    • Principal Investigator
      KOYA ATSUHIRO
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Asahikawa Medical College
  •  Clinical study for biomarker predicting vein graft intimal hyperplasiaPrincipal Investigator

    • Principal Investigator
      AZUMA NOBUYOSHI
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Asahikawa Medical College
  •  Endothelial cell senescence in venous system and epigeneticsPrincipal Investigator

    • Principal Investigator
      Azuma Nobuyoshi
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General surgery
    • Research Institution
      Asahikawa Medical College
  •  Inhibition of vein graft intimal hyperplasia by gene transferPrincipal Investigator

    • Principal Investigator
      AZUMA Nobuyoshi
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Asahikawa Medical College
  •  Gene-engineered hybrid prostheses for small vascular reconstruction

    • Principal Investigator
      HIRATA Satoshi
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Asahikawa Medical College
  •  Role of p38 MAP kinase in intimal hyperplasia of vein graft

    • Principal Investigator
      AKASAKA Nobuyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Asahikawa Medical College
  •  Difference of proliferation activity in animal and human vascular cells

    • Principal Investigator
      GOH Kazutomo, 山本 浩史
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Asahikawa Medical University
  •  同種血管移植片における内皮細胞の起源の解明Principal Investigator

    • Principal Investigator
      東 信良
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Thoracic surgery
    • Research Institution
      Asahikawa Medical College
  •  免疫制御剤を用いた同種血管移植の検討Principal Investigator

    • Principal Investigator
      東 信良
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General surgery
    • Research Institution
      Asahikawa Medical College

All 2023 2021 2020 2019 2018 2017 2016 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Current status of surgical treatment for acute aortic dissection in Japan: Nationwide database analysis2023

    • Author(s)
      Ogino H, KUmamaru H, Motomura N, Fujiyoshi T, Shimahara Y, Azuma N, Kinukawa N, Ueda Y, Okita Y
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: - Issue: 1 Pages: 11-23.e1

    • DOI

      10.1016/j.jtcvs.2023.11.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09156
  • [Journal Article] Predictive Model for Mortality Risk Including the Wound, Ischemia, Foot Infection Classification in Patients Undergoing Revascularization for Critical Limb Ischemia2019

    • Author(s)
      Azuma N, Takahara M, Kodama A, Soga Y, Terashi H, Tazaki J, Yamaoka T, Koya A, Iida O
    • Journal Title

      Circulation. Cardiovascular interventions.

      Volume: 12 Issue: 12

    • DOI

      10.1161/circinterventions.119.008015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08749
  • [Journal Article] Development of the gene therapy with a CRE decoy ODN to prevent vascular intimal hyperplasia2019

    • Author(s)
      Daiki Uchida, Yukihiro Saito, Nobuyoshi Azuma, et al.
    • Journal Title

      Journal of Vascular Surgery

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Journal Article] Evaluation of paramalleolar and inframalleolar bypasses in dialysis- and nondialysis- dependent patients with critical limb ischemia2018

    • Author(s)
      Shinsuke Kikuchi, Tadahiro Sasajima, Nobuyoshi Azuma, et al.
    • Journal Title

      Journal of Vascular Surgery

      Volume: 67 Pages: 826-837

    • NAID

      40021632096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Journal Article] Evaluation of paramalleolar and inframalleolar bypasses in dialysis- and nondialysis-dependent patients with critical limb ischemia.2018

    • Author(s)
      Kikuchi S, Sasajima T, Inaba M, Uchida D, Kokubo T, Saito Y, Koya A, Uchida H, Azuma N
    • Journal Title

      Journal of vascular surgery

      Volume: 67(3) Issue: 3 Pages: 826-837

    • DOI

      10.1016/j.jvs.2017.07.116

    • NAID

      40021632096

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Journal Article] Recent Progress of Bypass Surgery to the Dialysis-Dependent Patients with Critical Limb Ischemia2017

    • Author(s)
      Nobuyoshi Azuma,Shinsuke Kikuchi,Hiroko Okuda,Keisuke Miyake,Atsuhiro Koya
    • Journal Title

      Ann Vasc Dis

      Volume: 10 Issue: 3 Pages: 178-184

    • DOI

      10.3400/avd.ra.17-00076

    • NAID

      130006099984

    • ISSN
      1881-641X, 1881-6428
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Journal Article] Ulcer Healing After Peripheral Intervention-Can We Predict It Before Revascularization?-2014

    • Author(s)
      Azuma N, Koya A, Uchida D, Saito Y, Uchida H.
    • Journal Title

      Circulation Journal

      Volume: 78(8) Pages: 1791-1800

    • NAID

      130004427956

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24659580
  • [Journal Article] Cyclic adenosine monophosphate response-element binding protein activation by mitogen-activated protein kinase-activated protein kinase 3 and four-and-a-half LIM domains 5 plays a key role for vein graft intimal hyperplasia2013

    • Author(s)
      Nakanishi K, Saito Y, Azuma N, Sasajima T.
    • Journal Title

      Journal of Vascular Surgery

      Volume: 57 Issue: 1 Pages: 182-193

    • DOI

      10.1016/j.jvs.2012.06.082

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659580
  • [Journal Article] Effect on vein graft intimal hyperplasia of nuclear factor-kB decoy transfection using the second generation of HVJ vector.

    • Author(s)
      Shimizu N, Azuma N, Sasajima T. et al.
    • Journal Title

      J Cardiovascular Surgery (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591320
  • [Journal Article] Effect of nuclear factor-kB decoy tranfection using second generation of HVJ vector o vein graft intimal hyperplasia

    • Author(s)
      Noriyuki Shimizu, Nobuyoshi Azuma, Tadahiro Sasajima, et al.
    • Journal Title

      J Cardiovasular Surgery (In press)

    • Data Source
      KAKENHI-PROJECT-15591320
  • [Journal Article] Effect on vein graft intimal hyperplasia of nuclear factor-kB decoy transfection using the second generation of HVJ vector

    • Author(s)
      Shimizu N, Azuma N, Sasajima T, et al.
    • Journal Title

      J Cardiovascular Surgery (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591320
  • [Presentation] Current Status of Surgical Treatment for Acute Aortic Dissection in Japan: Nation-wide Database Analysis2023

    • Author(s)
      Hitoshi Ogino, Hiraku Kumamaru, NOboru Motomura, Yutaka Okita, Kenji Minatoya, Hitoshi Matsuda, Yosuke Inoue, Hideyuki Shimizu, Kimihiro Komori, Nobuya Zempo, Nobuyoshi Azuma, Toshiki Fujiyoshi, Yusuke shimahara, Kentaro Kamiya, Tohru Iwahashi, Naoko Kinukawa, Yuichi Ueda
    • Organizer
      103rd American Association for Thoracic Surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09156
  • [Presentation] Development of a biomarker for peripheral artery disease using extracellular vesicles associated miRNA2021

    • Author(s)
      栗山直也、吉岡祐亮、菊地信介、東信良、落谷孝広
    • Organizer
      International Society for Extracellular Vesicles 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08749
  • [Presentation] Pre-operative d-ROMs as a biomarker for predicting graft failure after distal bypass surgery in CLTI patients2020

    • Author(s)
      Daiki.U,Kikuchi S, Uchida D, Kuriyama N, Takahashi K, Kamada K, Tatsukawa T, Tochikubo A, Yoshida Y, Koya A, Azuma N
    • Organizer
      SVS 2020 Vascular Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08749
  • [Presentation] Possibility of Exosomal MicroRNAs Associated with Chronic Limb-Threatening Ischemia as a promising Biomarker2020

    • Author(s)
      菊地信介、吉岡祐亮、栗山直也、吉田有里、大塚蔵嵩、山本雄介、東信良、落谷孝広
    • Organizer
      International Society for Extracellular Vesicles 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08749
  • [Presentation] 末梢動脈疾患による重症下肢虚血におけるExosomal microRNAによるスクリーニグモダリティとしての可能性2020

    • Author(s)
      菊地信介、吉岡祐亮、栗山直也、吉田有里、東信良、落谷孝広
    • Organizer
      第7回日本細胞外小胞学会
    • Data Source
      KAKENHI-PROJECT-18K08749
  • [Presentation] 末梢動脈疾患による重症下肢虚血におけるExsomal microRNA 発現プロファイルから見たリキッドバイオプシーの可能性2020

    • Author(s)
      菊地信介、吉岡祐亮、大塚蔵嵩、山本雄介、東信良、落谷孝広
    • Organizer
      第4回Liquid Biopsy 研究会
    • Data Source
      KAKENHI-PROJECT-18K08749
  • [Presentation] Development of the Gene Therapy With CRE Decoy ODN to Prevent Vascular Intimal Hyperplasia2018

    • Author(s)
      Daiki Uchida, Yukihiro Saito, Nobuyoshi Azuma
    • Organizer
      American Heart Association ATVB/PVD 2018 Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Presentation] Gender difference of distal bypass graft patency:relationship between preoperatove foot infection and graft stenosis2018

    • Author(s)
      Hitoko Okuda,Atsuhiro Koya,Keisuke Miyake,Shinsuke Kikuchi and Nobuyoshi Azuma
    • Organizer
      第46回日本血管外科学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Presentation] GENDER-RELATED DIFFERENCES OF VEIN BYPASS GRAFT INTIMAL HYPERPLASIA AND CLINICAL OUTCOMES FOR CRITICAL LIMB ISCHEMIA;A PROPENSITY MATCHED ANALYSIS2017

    • Author(s)
      Hiroko Okuda,Shinsuke Kikuchi,Keisuke Miyake,Atsuhiro Koya,Yukihiro Saito,Nobuyosi Azuma
    • Organizer
      The European Society for Vascular Surgery 31st Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Presentation] Predictive Equation of Graft Flow in Distal Bypass Grafting in Critical Limb Ischemia2017

    • Author(s)
      Keisuke Miyake, MD, Shinsuke Kikuchi, MD, Hiroko Okuda, MD, Atsuhiro Koya, MD, Nobuyoshi Azuma , MD
    • Organizer
      2017 Vascular Annual Meeting San Diego
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293309
  • [Presentation] Involvement of hemodialysis to intimal hyperplasia development in paramalleolar bypass vein grafts2016

    • Author(s)
      Kikuchi S, Sasajima T, Uchida D, Koya A, Azuma N.
    • Organizer
      Society for Vascular Surgery
    • Place of Presentation
      Washintong DC, U.S.A.
    • Year and Date
      2016-06-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293309
  • 1.  SASAJIMA Tadahiro (20109515)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  菊地 信介 (80596297)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 3.  GOH Kazutomo (00234964)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  AKASAKA Nobuyuki (30281885)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  INABA Masashi (70151587)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  内田 大貴 (80422038)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 7.  吉田 有里 (50646057)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 8.  齊藤 幸裕 (80540583)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  YAMAZAKI Kosuke (20281884)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HIRATA Satoshi (80199067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  UCHIDA Hisashi (60301991)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HAGA Masae (80271766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KOYA ATSUHIRO (90463752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Ogino Hitoshi (60393237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  山本 浩史 (10270795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  善甫 宣哉 (00206666)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  松田 均 (20294217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  湊谷 謙司 (20393241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  古森 公浩 (40225587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  大北 裕 (40322193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 21.  本村 昇 (40332580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  志水 秀行 (50226247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 23.  藤吉 俊毅 (50617800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 24.  大平 成真 (70899814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  要 匡 (40264288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  蒔田 芳男 (20271778)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  紙谷 寛之 (30436836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  國岡 信吾 (30882724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  潮田 亮平 (50910270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  NAKANISHI Keisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi