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Otaka Michiro  大高 道郎

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OTAKA Michiro  大高 道郎

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Researcher Number 30250872
External Links
Affiliation (Current) 2025: 順天堂大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help 2007 – 2008: Juntendo University, 医学部, 准教授
2001 – 2006: Akita University, School of Medicine Lecturer, 医学部, 講師
1997 – 2000: Assistant Akita University School of Medicine, 医学部, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology / Biomedical engineering/Biological material science
Keywords
Principal Investigator
熱ショック蛋白質 / 分子シャペロン / 胃潰瘍 / 胃粘膜傷害 / COX-2 / molecular chaperon / heat shock protein / ストレス / 5-HT / TRH … More / 消化性潰瘍 / anti-apoptosis / MEK-ERK signaling / 薬剤代謝関連遺伝子 / アポトーシス抵抗性 / MEK-ERKシグナル / gastric mucosal lesion / gastric ulcer / stress / gastric mucosal restoration / gastric mucosal protection / 胃粘膜障害 / 亜鉛 / 粘膜修復 / 粘膜防御 / 損傷修復 / 胃粘膜病変 / 胃粘膜修復機構 / 胃粘膜防御機構 / neuro peptide / gastric mucosal damage / stress protein / NSAID / 神経ペプチド / ストレス蛋白質 / 胃粘膜 / HSP / HSP結合蛋白質 / ポストゲノム … More
Except Principal Investigator
gastric ulcer / 損傷修復 / HSP / サイトカイン / 胃潰瘍 / stress / HSP72 / HSP60 / ストレス / inflammatory cytokine / Adenosine / サイクリックAMP / 炎症性サイトカイン / アデノシン / therapy / contrast agent / wound healing / ultrasound / 潰瘍 / 胃粘膜 / 造影 / 治療 / 造影剤 / 損復治癒 / 超音波 / Helicobacter pylori / differentiation / migration / cytokine / growth factor / 細胞外基質 / インスリン様増殖因子 / 血管内皮細胞 / 線維芽細胞 / 細胞培養 / 消化性潰瘍 / 胃粘膜損傷 / ヘリコバクターピロリ / 細胞分裂 / ヘリコバクター・ピロリ / 細胞分化 / 細胞遊走 / 増殖因子 / adaptive cytoprotection / adaptation / pancreatitis / cytoprotection / heat shock protein / Heat Shock Proteins / adaptive cytoprotectior / 細胞防御 / 膵炎 / 分子シャペロン / heat shock protin / 熱ショック蛋白質 Less
  • Research Projects

    (8 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (6 People)
  •  Initial event of protein degeneration during the gastric mucosal injuryPrincipal Investigator

    • Principal Investigator
      OTAKA Michiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Analysis of the effect of activated MEK-ERK signaling in the chemoresistance-basal research to the molecular targeting therapyPrincipal Investigator

    • Principal Investigator
      OTAKA Michiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Analysis of anima models of inflammatory bowel disease and therapeutics application for inflammatory bowel disease

    • Principal Investigator
      WATANABE Sumio
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Role of molecular chaperon in gastric mucosal injury and restorationPrincipal Investigator

    • Principal Investigator
      OTAKA Michiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Ultrasound effect on gastric wound healing

    • Principal Investigator
      KONNO Kei
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Akita University
  •  EXPRESSION AND CYTOPROTECTIVE FUNCTION OF HEAT SHOCK PROTEINS IN THE GASTRIC MUCOSA MEDIATED BY CENTRAL NERVOUS SYSTEM-RELATED NEUROPEPTIDES.Principal Investigator

    • Principal Investigator
      OTAKA Michiro
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Biological modulation of the epithelial-mesenchymal interaction in gut wound repair process.

    • Principal Investigator
      WATANABE Sumio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      AKITA UNIVERSITY
      Juntendo University
  •  Cytoprotective function of heat shock proteins (stress proteins) in the pancreas

    • Principal Investigator
      MASAMUNE Osamu
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University

All 2009 2008 2007 2006 2005 2003 Other

All Journal Article Presentation Book

  • [Book] がんの温熱免疫療法2008

    • Author(s)
      大高道郎
    • Publisher
      診断と治療社, 東京
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] 消化管上皮細胞のHSP発現機構の分子生物学2009

    • Author(s)
      大高道郎、和泉裕子、渡辺純夫
    • Journal Title

      G. I. Research 17

      Pages: 154-158

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Heat shock protein 70 over-expressing gastric epithelial cells are resistant to indomethacin-induced apoptosis2009

    • Author(s)
      Hirata I, Naito Y, Handa O, Hayashi N, Mizushima K, Adachi S, Omatsu T, Okayama T, Kishimoto E, Ichikawa H, Takagi T, Kokura S, Otaka M, Yoshikawa T
    • Journal Title

      Digestion 79(4)

      Pages: 243-250

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Target molecules of molecular chaperon (HSP70 family) in injured gastric mucosa in vivo2009

    • Author(s)
      Otaka M, Odashima M, Izumi Y, Nagahara A, Osada T, Sakamoto N, Takada M, Takahashi T, Shimada Y, Tamaki K, Asaoka D, Itoh H, Watanabe S
    • Journal Title

      Life Sci 84(19-20)

      Pages: 664-667

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Expression and function of stress (heat shock) proteins in gastrointestinal tract2009

    • Author(s)
      Otaka M, Watanabe S
    • Journal Title

      Int J Heperthermia (in press)

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitis2009

    • Author(s)
      Izumi Y, Otaka M, Takahashi T, Takada M, Shimada Y, Asaoka D, Nagahara A, Itoh H, Watanabe S
    • Journal Title

      Life Sci 84(15-16)

      Pages: 517-522

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats2009

    • Author(s)
      Koizumi S, Odashima M. Otaka M, Jin M, Linden J, Watanabe S, Ohnishi H
    • Journal Title

      J Gastroenterol 44(5)

      Pages: 419-425

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Target molecules of molecular chaperon (HSP70 family) in injured gastric mucosa in vivo.2009

    • Author(s)
      Otaka M, et al.
    • Journal Title

      Life Sci

      Pages: 664-667

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] 分子シャペロンと消化器疾患2008

    • Author(s)
      伊藤英晃, 大高道郎, 渡辺純夫
    • Journal Title

      分子細胞治療 7

      Pages: 36-42

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] 消化器疾患における亜鉛の重要性-亜鉛による消化管粘膜保護作用を中心に-2008

    • Author(s)
      大高道郎, 渡辺純夫
    • Journal Title

      G. I. Research 16

      Pages: 164-169

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP902008

    • Author(s)
      Ishida R, Takaoka Y, Yamamotoa S, Miyazaki T, Otaka M, Watanabe S, Komatsuda A, Wakui H, Sawada K, Kubota H, Itoh H
    • Journal Title

      FEBS. Lett 582(28)

      Pages: 3879-3883

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] 消化器疾患における亜鉛の有用性-胃、大腸粘膜におけるHSP誘導作用を中心に-2007

    • Author(s)
      大高道郎, 小田嶋傑, 渡辺大亮, 三上健一郎, 渡辺純夫
    • Journal Title

      Biomed. Res. Trace Elements 18

      Pages: 15-19

    • NAID

      10018910824

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of the selective type III phospshodiesterase in rats2007

    • Author(s)
      Odashima M, Otaka M (Equalcontribution to the firstauthor), Ohba R, Jin M, Horikawa Y, Matsuhashi T, Hatakeyama N, Oyake J, Watanabe S
    • Journal Title

      Dig. Dis. Sci. 52

      Pages: 1355-1359

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Mechanical strain stress suppresses expression of HPS70 and wound restoration in the gastric mucosal cells2007

    • Author(s)
      Odashima M, Otaka M, et. al.
    • Journal Title

      Dig Dis Sci 52

      Pages: 3087-3091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Mitigation of stress-induced gastric mucosal lesion by specific type IV phosphodiesterase inhibitor2007

    • Author(s)
      Kato S, Otaka M (Equalcontribution to the firstauthor), Odashima M, Sato T, Jin M, Matsuhashi T, Konishi N, Watanabe S
    • Journal Title

      Dig. Dis. Sci. 52(3)

      Pages: 711-716

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Protective effect of novel rice extract against ethanol-induced gastric mucosal injury in rat2007

    • Author(s)
      Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Wada I, Horikawa Y, Ohba R, Oyake J, Hatakeyama N, Watanabe S
    • Journal Title

      Dig Dis Sci 52(2)

      Pages: 434-441

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Mechanical strain stress suppresses expression of HSP70 and wound restoration in the gastric mucosal cells2007

    • Author(s)
      Odashima M, Otaka M (Equalcontribution to the firstauthor), Matsuhashi T, Jin M, Horikawa Y, Ohba R, Itoh H, Watanabe S
    • Journal Title

      Dig. Dis. Sci 52(11)

      Pages: 3087-3091

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] 消化管器疾患におけるストレス蛋白質(分子シャペロン)の発現とその意義-分子シャペロン誘導療法への展望も含めて-2007

    • Author(s)
      大高道郎
    • Journal Title

      日本ストレス学会誌 21

      Pages: 141-151

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone(HSP-inducer)2007

    • Author(s)
      Otaka M, et. al.
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 399-404

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Effect of Alcohol Consumption on Leptin Level in Serum, Adipose Tissue,and Gastric Mucosa2007

    • Author(s)
      Otaka M, et. al.
    • Journal Title

      Dig Dis Sci 52

      Pages: 3066-3069

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Effect of alcohol consumption on leptin level in serum,adipose tissue and gastric mucosa2007

    • Author(s)
      Otaka M, Konishi N, Odashima M, Jin M, Wada I, Matsuhashi T, Ohba R, Watanabe S
    • Journal Title

      Dig. Dis. Sci 52(11)

      Pages: 3066-3069

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] MEK-activationsuppresses CPT11-induced apoptosis in rat intestinal epithelial cells through COX-2- dependent mechanism2007

    • Author(s)
      Horikawa Y, Otaka M, Komatsu K, Jin M, Odashima M, Wada I, Matsuhashi T, Ohba R, Oyake J, Hatakeyama N, DuBois R, Watanabe S
    • Journal Title

      Dig. Dis. Sci 52(10)

      Pages: 2757-2765

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer)2007

    • Author(s)
      Otaka M, Yamamoto S, Ogasawara K, Takaoka Y, Noguchi S, Miyazaki T, NakaiA, Odashima M, Matsuhashi T, Watanabe S, Itoh H
    • Journal Title

      Biochem. Biophys. Res. Commun. 353(2)

      Pages: 399-404

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] 高齢者消化器疾患における亜鉛の重要性-亜鉛による消化管粘膜保護作用も含めて-2007

    • Author(s)
      大高道郎, 小田嶋傑, 渡辺大亮, 渡辺純夫
    • Journal Title

      老年消化器病 19

      Pages: 73-78

    • Data Source
      KAKENHI-PROJECT-19590712
  • [Journal Article] Systemic stress increases serum leptin level.2006

    • Author(s)
      Konishi N, Otaka M, et al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 21

      Pages: 1099-1102

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590610
  • [Journal Article] Specific type IV phosphodiesterase inhibitor ameliorates cerulein-induced pancreatitis in rats2006

    • Author(s)
      Sato T, Otaka M, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 346

      Pages: 339-344

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590610
  • [Journal Article] Is Mongolian gerbil really adequate host animal for study of Helicobacter pylori infection-induced gastritis and cancer?2006

    • Author(s)
      Otaka M, Konishi N, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 347

      Pages: 297-300

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590610
  • [Journal Article] A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice.2006

    • Author(s)
      Odashima M, Otaka M, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 347

      Pages: 949-954

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590610
  • [Journal Article] Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells.2006

    • Author(s)
      Komatsu, K, Otaka M, et al.
    • Journal Title

      Molecular Cancer 5

      Pages: 63-63

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590610
  • [Journal Article] Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats.2005

    • Author(s)
      Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Konishi N, Wada I, Sato T, Horikawa Y, Ohba R, Oyake J, Hatakeyama N, Watanabe S.
    • Journal Title

      J Gastroenterol Hepatol. 20(1)

      Pages: 135-140

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590617
  • [Journal Article] Selective adenosine A receptor agonist, ATL-146e, attenuates stress-induced gastric lesions in rats.2005

    • Author(s)
      Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Matsuhashi T, Horikawa Y, Hatakeyama N, Oyake J, Ohba R, Linden J, Watanabe S.
    • Journal Title

      J Gastroenterol Hepatol. 20(2)

      Pages: 275-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590617
  • [Journal Article] Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats.2005

    • Author(s)
      Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Konishi N, et al.
    • Journal Title

      J Gastroenterol Hepatol. 20

      Pages: 135-140

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590617
  • [Journal Article] Selective adenosine A receptor agonist, ATL-146e, attenuates stress-induced gastric lesions in rats.2005

    • Author(s)
      Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Matsuhashi T, et al.
    • Journal Title

      J Gastroenterol Hepatol 20

      Pages: 275-280

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590617
  • [Journal Article] Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats.2003

    • Author(s)
      Nakamura C, Otaka M, Odashima M, Jin M, Konishi N, Horikawa Y, et al.
    • Journal Title

      Pathophysiology. 9

      Pages: 195-200

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590617
  • [Journal Article] Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats.2003

    • Author(s)
      Nakamura C, Otaka M, Odashima M, Jin M, Konishi N, Horikawa Y, Matsuhashi T, Watanabe S.
    • Journal Title

      Pathophysiology. 9(3)

      Pages: 195-200

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590617
  • [Journal Article] MEK-activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through COX-2-dependent mechanism

    • Author(s)
      Horikawa Y, Otaka M, et al.
    • Journal Title

      Digestive Diseases and Sciences (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590610
  • [Journal Article] MEK-ativation suppresses CPT11-induced in rat intestinal epithelial cells through COX-2-dependent mechanism

    • Author(s)
      Horikawa Y, Otaka M, et al.
    • Journal Title

      Digestive Diseases and Sciences (In press)

    • Data Source
      KAKENHI-PROJECT-17590610
  • [Presentation] Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitis2009

    • Author(s)
      Izumi, Y., Otaka, M., Takahashi, T., Takada, M., Shimada, Y., Asaoka, D., Nagahara, A., Itoh, H. and Watanabe, S.
    • Organizer
      110th the American Gastroenterological Association
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Presentation] Investigation of laryngo-trancheal lesion in a rat chronic acid reflux esophagitis2009

    • Author(s)
      Oguro, M., Nagahara, A., Asaoka, D., Nakayama, H., Izumi, Y., Otaka, M. and Watanabe, S.
    • Organizer
      110th the American Gastroenterological Association
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Presentation] Contribution of heat shock proteins expression to gender difference in development of stress-induced gastric mucosal injury in rats2009

    • Author(s)
      Takahashi, T., Otaka, M., Izumi, Y., Takada, M., Shimada, Y., Itoh, H. and Watanabe, S.
    • Organizer
      110th the American Gastroenterological Association
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Presentation] Over-expression of a 70-kDa heat shock protein enhances cytoprotective function against hydrogen peroxide or NSAIDs-induced smallintestinal epithelial cells in jury2009

    • Author(s)
      Takada, M., Otaka, M., Takahashi, T., Izumi, Y., Shimada, Y., Itoh, H. and Watanabe, S.
    • Organizer
      110th the American Gastroenterological Association
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Presentation] Target molecules of molecular chaperone (HSP70) in injured gastric mucosal cells are cytoskeletal myosin2008

    • Author(s)
      Izumi, Y., Otaka, M., Nagahara, A., Asaoka, D., Sakamoto, N., Osada, T., Kawabe, M., Ohkusa, T., Odashima, M., Itoh, H. and Watanabe, S.
    • Organizer
      109th the American Gastroenterological Association
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-19590712
  • [Presentation] Target molecules of molecular chaperon (HSP70 family) in injured gastric mucosa in vivo.2008

    • Author(s)
      Izumi Y, Otaka M, et al.
    • Organizer
      米国消化器病学会(AGA)
    • Place of Presentation
      サンディエゴ(米国)
    • Data Source
      KAKENHI-PROJECT-19590712
  • 1.  WATANABE Sumio (20138225)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  ITOH Hideaki (80168369)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  MASAMUNE Osamu (50004643)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MIYAZAKI Akihisa (20200149)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KONNO Kei (00323139)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ODASHIMA Masaru (40375267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results

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