KUBO Yoshinao 久保嘉直

… Alternative Names

Kubo Yoshinao 久保嘉直

久保嘉直クボヨシナオ

Less

Researcher Number	30273527
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 熱帯医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 熱帯医学研究所, 准教授 2019 – 2023: 長崎大学, 熱帯医学研究所, 准教授 2014 – 2017: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2012 – 2013: 長崎大学, 医歯(薬)学総合研究科, 准教授 2010 – 2012: 長崎大学, 大学院・医歯薬学総合研究科, 准教授 2010: 長崎大学, 熱帯医学研究所, 助教 2002 – 2003: 長崎大学, 熱帯医学研究所, 助手
Review Section/Research Field	Principal Investigator Virology / Basic Section 90120:Biomaterials-related / Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 54030:Infectious disease medicine-related / Virology / Living organism molecular science
Keywords	Principal Investigator インターフェロン / HIV / レトロウイルス / 糖蛋白質 / ラッサウイルス / クルマエビ / フコイダン / 海産生物 / mTOR / 節足動物 … More / lamellarin sulfate / エボラウイルス / 新型コロナウイルス / 甲殻類 / 海産下等動物 / lamellarin alpha / 下等動物 / 獲得免疫 / GILT / interferon / IFI6 / FAT10 / IDO1 / エンドサイトーシス / エンドソーム / ヒト免疫不全症ウイルス / 自然免疫 / カテプシンB / cystatin-C / 糖鎖付加 / 膜融合 / エンベロープ蛋白質 … More Except Principal Investigator 公衆衛生 / 顧みられない熱帯病 / ヘビ / へび / 蛇咬傷 / コレラ / 細菌毒素 / インターフェロンγ / GILT / ジフテリア / A型インフルエンザウイルス / インターフェロン誘導遺伝子ISGs / A型インフルエンザ・ウイルス / トリプシノーゲン遺伝子 / インターフェロン調節因子IRFs / インターフェロン調節因子 / インターフェロン誘導遺伝子 / インターフェロン誘導遺伝子(ISGs) / インターフェロン調節因子(IRFs) / エンテロキナーゼ / トリプシノーゲン / インフルエンザウイルス / 坑HIV剤 / 抗ＨＩＶ剤 / 侵入阻害 / 構造活性相関 / 抗HIV剤 / ラメラリンサルフェート Less

Novel PCR Diagnostic Assay for Enhanced Snakebite Surveillance in the Eastern Visayas, Philippines
- Principal Investigator
  
  青木義紘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Nagasaki University
Development of conditional replication system of Lassa virus glycoprotein-expressing retroviral vectorPrincipal Investigator
- Principal Investigator
  
  久保嘉直
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nagasaki University
Basic and clinical study on the role of GILT on pathogenicity of bacterial toxins
- Principal Investigator
  
  高橋健介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Identification of novel host anti-HIV-1 factors using sea lower animalsPrincipal Investigator
- Principal Investigator
  
  Kubo Yoshinao
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagasaki University
Understanding the mechanism by which an interfeon-gamma-induced, mitochondria-localized novel protein inhibits virus infectionPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshinao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.
- Principal Investigator
  
  HAYASHI Hideki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
Development of Lamellarin Type Anti-HIV Compoundswith a New Mechanism of Action
- Principal Investigator
  
  FUKUDA Tsutomu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Nagasaki University
How does cystatin-C enhance CD4-independent HIV infection?Principal Investigator
- Principal Investigator
  
  KUBO Yoshinao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
レトロウイルスエンベロープ蛋白質による膜融合のシグナル伝達経路Principal Investigator
- Principal Investigator
  
  久保嘉直
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University

[Journal Article] Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein2022
- Author(s)
  Izumida Mai、Kakoki Katsura、Hayashi Hideki、Matsuyama Toshifumi、Kubo Yoshinao
- Journal Title
  
  Small GTPases
  
  Volume: 13 Issue: 1 Pages: 162-182
- DOI
  10.1080/21541248.2021.1939631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-22K08581
[Journal Article] Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-22022
- Author(s)
  Izumida Mai、Kotani Osamu、Hayashi Hideki、Smith Chris、Fukuda Tsutomu、Suga Koushirou、Iwao Masatomo、Ishibashi Fumito、Sato Hironori、Kubo Yoshinao
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 4 Pages: 816-816
- DOI
  10.3390/v14040816
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-22K08581, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-18K16773
[Journal Article] IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement2022
- Author(s)
  Kubo Yoshinao、Yasui Kiyoshi、Izumida Mai、Hayashi Hideki、Matsuyama Toshifumi
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 14 Pages: 2240-2240
- DOI
  10.3390/cells11142240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-22K08581, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-18K16773
[Journal Article] Unique mode of antiviral action of a marine alkaloid against Ebola virus and SARS-CoV-22022
- Author(s)
  Izumida Mai, Kotani Osamu, Hayashi Hideki, Smith Cris, Fukuda Tsutomu, Suga Koushirou, Iwao Masatomo, Ishibashi Fumito, Sato Hironori, Kubo Yoshinao
- Journal Title
  
  Viruses
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07593
[Journal Article] Antivirus activity, but not thiolreductase activity, is conserved in interferon-gamma-inducible GILT protein in arthropod2021
- Author(s)
  Izumida Mai、Hayashi Hideki、Smith Chris、Ishibashi Fumito、Suga Koushirou、Kubo Yoshinao
- Journal Title
  
  Molecular Immunology
  
  Volume: 140 Pages: 240-249
- DOI
  10.1016/j.molimm.2021.10.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-18K16773
[Journal Article] Efficient viral delivery of Cas9 into human safe harbor2020
- Author(s)
  Hayashi Hideki、Kubo Yoshinao、Izumida Mai、Matsuyama Toshifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21474-21474
- DOI
  10.1038/s41598-020-78450-8
- NAID
  120006980740
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-18K16773
[Journal Article] Human T-cell lymphotropic virus type-1 infection associated with sarcopenia: community-based cross-sectional study in Goto, Japan2020
- Author(s)
  Yamanashi Hirotomo、Nobusue Kenichi、Nonaka Fumiaki、Honda Yukiko、Shimizu Yuji、Kawashiri Shin-Ya、Izumida Mai、Kubo Yoshinao、Tamai Mami、Nagata Yasuhiro、Yanagihara Katsunori、Kulkarni Bharati、Kinra Sanjay、Kawakami Atsushi、Maeda Takahiro
- Journal Title
  
  Aging
  
  Volume: 12 Issue: 15 Pages: 15504-15513
- DOI
  10.18632/aging.103736
- NAID
  120006988545
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-19K07915, KAKENHI-PROJECT-18K16773, KAKENHI-PROJECT-17H03740
[Journal Article] Production of Vesicular Stomatitis Virus Glycoprotein-Pseudotyped Lentiviral Vector Is Enhanced by Ezrin Silencing2020
- Author(s)
  Izumida Mai、Togawa Kei、Hayashi Hideki、Matsuyama Toshifumi、Kubo Yoshinao
- Journal Title
  
  Frontiers in Bioengineering and Biotechnology
  
  Volume: 8 Pages: 368-368
- DOI
  10.3389/fbioe.2020.00368
- NAID
  120006988191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-18K16773
[Journal Article] Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection Via Endocytosis or Macropinocytosis2020
- Author(s)
  Izumida Mai、Hayashi Hideki、Tanaka Atsushi、Kubo Yoshinao
- Journal Title
  
  Viruses
  
  Volume: 12 Issue: 7 Pages: 722-722
- DOI
  10.3390/v12070722
- NAID
  120006988126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-18K16773
[Journal Article] The Spirocyclic Imine from a Marine Benthic Dinoflagellate, Portimine, Is a Potent Anti-Human Immunodeficiency Virus Type 1 Therapeutic Lead Compound2019
- Author(s)
  Izumida Mai、Suga Koushirou、Ishibashi Fumito、Kubo Yoshinao
- Journal Title
  
  Marine Drugs
  
  Volume: 17 Issue: 9 Pages: 495-495
- DOI
  10.3390/md17090495
- NAID
  120006988413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-18K16773
[Journal Article] CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection2019
- Author(s)
  Bai Lanlan、Sato Hirotaka、Kubo Yoshinao、Wada Satoshi、Aida Yoko
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 12 Pages: 14516-14527
- DOI
  10.1096/fj.201901528r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07593
[Journal Article] Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.2018
- Author(s)
  Hayashi H, Kubo Y, Izumida M, Takahashi E, Kido H, Sato K, Yamaya M, Nishimura H, Nakayama K, Matsuyama T.
- Journal Title
  
  Front Cell Infect Microbiol
  
  Volume: 8 Pages: 91-91
- DOI
  10.3389/fcimb.2018.00091
- NAID
  120006937672
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15319, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-15K08499
[Journal Article] Rab3a-Bound CD63 Is Degraded and Rab3a-Free CD63 Is Incorporated into HIV-1 Particles.2017
- Author(s)
  Kubo Y, Masumoto H, Izumida M, Kakoki K, Hayashi H, Matsuyama T
- Journal Title
  
  Front Microbiol
  
  Volume: 29 Pages: 1653-1653
- DOI
  10.3389/fmicb.2017.01653
- NAID
  120006987411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15319, KAKENHI-PROJECT-15K08499
[Journal Article] Fragments of target cells are internalized into retroviral envelope protein-expressing cells during cell-cell fusion by endocytosis.2016
- Author(s)
  M. Izumida, H. Kamiyama, T. Suematsu, E. Honda, Y. Koizumi, K. Yasui, H. Hayashi, K. Ariyoshi, Y. Kubo
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 6 Pages: 1552-1552
- DOI
  10.3389/fmicb.2015.01552
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08499
[Journal Article] Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-12016
- Author(s)
  Y. Kubo, M. Izumida, Y. Yashima, H. Yoshii-Kamiyama, Y. Tanaka, K. Yasui, H. Hayashi, T. Matsuyama
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 44 Pages: 71255-71273
- DOI
  10.18632/oncotarget.12104
- NAID
  120006847273
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08499
[Journal Article] Susceptibility of muridae cell lines to ecotropic murine leukemia virus and the cationic amino acid transporter 1 viral receptor sequences: implications for evolution of the viral receptor.2014
- Author(s)
  Kakoki K, Shinohara A, Izumida M, Koizumi Y, Honda E, Kato G, Igawa T, Sakai H, Hayashi H, Matsuyama T, Morita T, Koshimoto C, Kubo Y.
- Journal Title
  
  Virus Genes.
  
  Volume: 48 Issue: 3 Pages: 448-456
- DOI
  10.1007/s11262-014-1036-1
- NAID
  120006986554
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590555, KAKENHI-PROJECT-26292170
[Journal Article] Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus.2014
- Author(s)
  Kakoki K, Kamiyama H, Izumida M, Yashima Y, Hayashi H, Yamamoto N, Matsuyama　T, Igawa T, Sakai H, Kubo Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 447 Issue: 1 Pages: 216-222
- DOI
  10.1016/j.bbrc.2014.03.154
- NAID
  120006986603
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590555
[Journal Article] A short variant BTBD2 as a novel negative regulator of IRF-associated signalling.2013
- Author(s)
  Chua KJ, Kubo Y, Ma Y, Yasui K, Matsuyama T, and Hayashi H.
- Journal Title
  
  Int J Integrative Biol
  
  Volume: 14 Pages: 3138-3138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590555
[Journal Article] CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit2013
- Author(s)
  H. Kamiyama, K. Kakoki, S. Shigematsu, M. Izumida, Y. Yashima, Y. Tanaka, H. Hayashi, T. Matsuyama, H. Sato, N. Yamamoto, T. Sano, Y. Shidoji, Y. Kubo
- Journal Title
  
  AIDS Res.Hum.Retrovir.
  
  Volume: 29 Issue: 2 Pages: 279-88
- DOI
  10.1089/aid.2012.0174
- NAID
  120006985740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-22659092, KAKENHI-PROJECT-23617020, KAKENHI-PROJECT-24590555
[Journal Article] Alarin but not its alternative-splicing form, GALP (Galanin- like peptide) has antimicrobial activity.2013
- Author(s)
  A. Wada, Y. Kuboら
- Journal Title
  
  Biochemical and Biophysical Research Communication
  
  Volume: 434 Issue: 2 Pages: 223-227
- DOI
  10.1016/j.bbrc.2013.03.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24592432, KAKENHI-PROJECT-24651263
[Journal Article] Serum starvation activates NF-kB through G protein B2 subunit-mediated signal2012
- Author(s)
  T. Kohno, Y. Kubo, K. Yasui, M. Haraguchi, S. Shigematsu, K.J. Chua, T. Matsuyama, H. Hayashi.
- Journal Title
  
  DNA Cell Biol
  
  Volume: 31 Issue: 11 Pages: 1636-44
- DOI
  10.1089/dna.2012.1666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-22659092, KAKENHI-PROJECT-24590555
[Journal Article] Retrovirus entry by endocytosis and cathepsinproteases.2012
- Author(s)
  Y. Kubo, H. Hayshi, T. Matsuyama, H. Sato, N. Yamamoto.
- Journal Title
  
  Adv.Virol.
  
  Volume: 2012 Pages: 640894-640894
- DOI
  10.1155/2012/640894
- NAID
  120006985742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-24590555
[Journal Article] Infection of XC Cells by MLVs and Ebola Virus Is Endosome-Dependent but Acidification-Independent2011
- Author(s)
  神山陽香, 岩尾正倫, 久保嘉直, 他
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 10 Pages: e26180-e26180
- DOI
  10.1371/journal.pone.0026180
- NAID
  120006985272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J07637, KAKENHI-PROJECT-20310135, KAKENHI-PROJECT-22590416
[Journal Article] Xenotropic and other murine leukemia virus-related viruses in humans2011
- Author(s)
  A.S.Khan, M.McClure, Y.Kubo, P.Jolicoeur
- Journal Title
  
  Advances in Virology
  
  Volume: 2011 Pages: 787394-787394
- DOI
  10.1155/2011/787394
- NAID
  120006985743
- Data Source
  KAKENHI-PROJECT-22590416
[Journal Article] Surfactant protein C G100S mutation causes familial pulmonary fibrosis in Japanese kindred2011
- Author(s)
  Ono S, Tanaka T, Ishida M, Kinoshita A, Fukuoka J, Takaki M, Sakamoto N,Ishimatsu Y, Kohno S, Hayashi T, Senba M, Yasunami M, Kubo Y, Yoshida LM, Kubo H, Ariyoshi K, Yoshiura K, Morimoto K.
- Journal Title
  
  Eur Respir J
  
  Volume: 38 Issue: 4 Pages: 861-869
- DOI
  10.1183/09031936.00143610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-22659071
[Journal Article] Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of lrf2 in trypsinogen5 gene transcription2011
- Author(s)
  Hayashi M, (他5名) Nakashima T, et al
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Issue: 46 Pages: 18766-71
- DOI
  10.1073/pnas.1116273108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659427, KAKENHI-PROJECT-22590416
[Journal Article] Surfactant protein C G100S mutation causes familial pulmonary fibrosis in Japanese kindred2011
- Author(s)
  S.Ono, T.Tanaka, M.Ishida, A.Kinoshita, J.Fukuoka, M.Takaki, N.Sakamoto, Y.Ishimatsu, S.Kohno, T.Hayashi, M.Senba, M.Yasunami, Y.Kubo, L.M.Yoshida, H.Kubo, K.Ariyoshi, K.Yoshiura, K.Morimoto
- Journal Title
  
  European Respiratory Journal
  
  Volume: (In press 掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416
[Journal Article] CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B2011
- Author(s)
  H. Yoshii, H. Kamiyama, K. Goto, K. Oishi, N. Katsunuma, Y. Tanaka, H. Hayashi, T. Matsuyama, H. Sato, N. Yamamoto, Y. Kubo
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 4 Pages: e19352-e19352
- DOI
  10.1371/journal.pone.0019352
- NAID
  120006985096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416
[Journal Article] Synthesis, structure-activity relationships, and mechanism of action of anti HIV-1 lamellarin α 20-sulfate analogues2011
- Author(s)
  神山陽香, 岩尾正倫, 久保嘉直, 他
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 19 Issue: 24 Pages: 7541-7550
- DOI
  10.1016/j.bmc.2011.10.030
- NAID
  120006985218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J07637, KAKENHI-PROJECT-20310135, KAKENHI-PROJECT-22510235, KAKENHI-PROJECT-22590416
[Journal Article] Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel2011
- Author(s)
  H. Shindo, K. Yasui, K. Yamamoto, K. Honma, K. Yui, T. Kohno, Y. Ma, K.J. Chua, Y. Kubo, H. Aihara, T. Ito, T.Nagayasu, T. Matsuyama, H. Hayashi.
- Journal Title
  
  Cytokine
  
  Volume: 56 Issue: 3 Pages: 564-72
- DOI
  10.1016/j.cyto.2011.08.014
- NAID
  120006985203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-22659092, KAKENHI-PUBLICLY-23131510
[Patent] 蛋白質分子、ポリヌクレオチド、蛋白質分子の製造方法、方法及び検査方法2024
- Inventor(s)
  久保嘉直、菅向志郎
- Industrial Property Rights Holder
  久保嘉直、菅向志郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-014783
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-19K07593
[Patent] ウイルス感染症の予防又は治療剤2012
- Inventor(s)
  久保嘉直、神山陽香、鹿子木桂、松山俊文、林日出喜
- Industrial Property Rights Holder
  久保嘉直、神山陽香、鹿子木桂、松山俊文、林日出喜
- Industrial Property Rights Type
  特許
- Filing Date
  2012-10-30
- Overseas
- Data Source
  KAKENHI-PROJECT-22590416
[Patent] ウイルス感染症の予防又は治療剤2012
- Inventor(s)
  久保嘉直、神山陽香、鹿子木桂、松山俊文、林日出喜
- Industrial Property Rights Holder
  長崎大学
- Filing Date
  2012-10-30
- Overseas
- Data Source
  KAKENHI-PROJECT-22590416
[Patent] レトロウイルス感染抑制剤2011
- Inventor(s)
  久保嘉直、神山陽香
- Industrial Property Rights Holder
  長崎大学、興和株式会社
- Filing Date
  2011-09-27
- Overseas
- Data Source
  KAKENHI-PROJECT-22590416
[Patent] レトロウイルス感染抑制剤2007
- Inventor(s)
  久保嘉直、神山陽香
- Industrial Property Rights Holder
  長崎大学、興和株式会社
- Industrial Property Number
  2008-544091
- Filing Date
  2007-09-20
- Overseas
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Unique mode of antiviral action of a marine alkaloid against Ebola virus and SARS-CoV-22023
- Author(s)
  Kubo Y, Izumida M, Kotani O, Hayashi H, Smith C, Fukuda T, Suga K, Iwao M, Ishibashi F, Sato H.
- Organizer
  国際熱帯医学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07593
[Presentation] 宿主防御因子GBP2によるEnv糖蛋白質切断阻害に対するマウス白血病ウイルスの回避機構2022
- Author(s)
  久保嘉直、泉田真生
- Organizer
  日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07593
[Presentation] 宿主防御因子GBP2によるウイルスEnv糖蛋白質切断抑制に対するマウス白血病ウイルスの回避機構2022
- Author(s)
  久保嘉直、泉田真生
- Organizer
  日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08581
[Presentation] Sulfated polysaccharides inhibit Ebola virus glycoprotein-mediated retroviral vector infection2021
- Author(s)
  Kubo Yoshinao, Izumida Mai, Kotani Osamu, Hayashi Hideki, Ariyoshi Koya, Sato Hironori
- Organizer
  第６２回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-19K07593
[Presentation] Lamellarin alpha 20-sulfate inhibits SARS-CoV-2 infection2020
- Author(s)
  Yoshinao Kubo, Izumida Mai, Koya Ariyosi
- Organizer
  日本熱帯医学会
- Data Source
  KAKENHI-PROJECT-19K07593
[Presentation] マウス白血病ウイルスエンベロープ蛋白質のC末端Rペプチドは細胞表面受容体との相互作用を負に制御する2019
- Author(s)
  久保嘉直、泉田真生、林日出喜、松山敏文
- Organizer
  日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07593
[Presentation] Identification of gamma-interferon inducible antiretroviral host factors2019
- Author(s)
  Kubo Y、Izumida M、Hayashi H、Matsuyama T
- Organizer
  International Workshop on Retroviral Pathogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07593
[Presentation] Rab3a is required for virion production of murine leukemia virus2017
- Author(s)
  Y. Kubo, M. Izumida, H. Hayashi
- Organizer
  日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Identification of novel host anti-HIV-1 factors that are induced by interferon gamma2017
- Author(s)
  Y. Kubo, M. Izumida, H. Hayashi, T. Matsuyama
- Organizer
  Nagasaki-Singapore Medical Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Rab3a is required for virion production of murine leukemia virus2017
- Author(s)
  M. Izumida, H. Hayashi, Y. Kubo
- Organizer
  International Workshop on Retroviral Pathogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Role of a samll GTP-binding protein, Rab3a, in the formation of HIV-1 virion2016
- Author(s)
  Y.Kubo, M. Izumida, H. Masumoto, K. Yasui, H. Hayashi, T. Matsuyama
- Organizer
  日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Identification of a CD63 binding protein and its role in HIV replication2015
- Author(s)
  Y. Kubo, M. Izumida, H. Masumoto, K. Yasui, H. Hayashi, T. Matsuyama
- Organizer
  第６３回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Placenta formation by human endogenous retrovirus is inhibited by interferons.2015
- Author(s)
  M. Izumida, Y. Kubo, H. Hayashi, K. Yasui, T. Matsuyama
- Organizer
  第６３回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] インターフェロンG誘導遺伝子GILTによるHIV粒子産物抑制機構の解明2013
- Author(s)
  久保嘉直、神山陽香、泉田真生、田中勇悦、安井潔、佐藤祐徳、山本直樹、松山俊文、林日出喜
- Organizer
  第61回日本ウイルス学会学術総会
- Place of Presentation
  神戸国際会議場 (神戸市中央区)
- Data Source
  KAKENHI-PROJECT-24590555
[Presentation] Role of SAMHD1 in its function as an innate immune factor agaist HIV-1 infection2012
- Author(s)
  S. Shigematsu, Y. Kuboら
- Organizer
  Frontiers of Immunology in Health and Diseases
- Place of Presentation
  China
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Role of SAM domain of SAMHD1 in its function as an innate immune factor against HIV-1 infection2012
- Author(s)
  S. Shigematsu, M. Izumida, H. Hayashi, T. Matsuyama, Y. Kubo.
- Organizer
  Frontiers of Immunology in Health & Diseases, Cold Spring Harbor Asia Conference
- Place of Presentation
  China
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] SAMHD1のHIV感染抑制活性におけるSAMドメインの機能2012
- Author(s)
  重松小百合、林日出喜、松山俊文、久保嘉直
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] SAMHD1のHIV感染抑制活性におけるSAMドメインの機能2012
- Author(s)
  重松小百合、林日出喜、松山俊文、久保嘉直
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] SAMHD1のHIV-1感染抑制活性におけるSAMドメインの機能2012
- Author(s)
  重松小百合, 久保嘉直ら
- Organizer
  第６０回ウイルス学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] SAMHD1のHIV-1感染抑制活性におけるSAMドメインの機能2012
- Author(s)
  久保嘉直ら
- Organizer
  第２６回日本エイズ学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] 血清枯渇はG Protein β2を介したNF-κB経路を活性化する2012
- Author(s)
  安井潔, 河野友子、久保嘉直、原口恵、重松小百合、蔡君柔、松山俊文、林日出喜
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24590555
[Presentation] Structure-activity relationship of anti-HIV-1 compound, lamellarin sulfates2011
- Author(s)
  H. Kamiyama, Y. Kubo, H. Sato, N. Yamamoto, T. Fukuda, M. Iwao.
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Unprocessed cathepsin L is active in XC cells in which XMRV infection is pH-independent.2011
- Author(s)
  Y. Kubo, H. Kamiyama, K. Kakoki, T. Igawa, H. Sakai, N. Yamamoto
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Structure-Activity Relationship of Anti-HIV-1 Compound, Lamellarin Sulfates2011
- Author(s)
  Haruka Kamiyama, Yoshinao Kubo, Hironori Sato, Naoki Yamamoto, Tsutomu Fukuda, Masatomo Iwao
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22510235
[Presentation] XMRV infection confers androgen-dependent cell growth of a prostate cancer cell line, LNCaP, to androgen-independent.2011
- Author(s)
  K. Kakoki, T. Igawa, H. Sakai, H. Hayashi, T. Matsuyama, N. Yamamoto, Y. Kubo.
- Organizer
  23th Workshop on Retroviral Pathogenesis. Montpellier
- Place of Presentation
  France
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] XMRV infection confers androgen-dependent cell growth of a prostate cancer cell line, LNCaP, to androgen-independent2011
- Author(s)
  K.Kakoki, T.Igawa, H.Sakai, H.Hayashi, T.Matsuyama, N.Yamamoto, Y.Kubo
- Organizer
  International workshop on retroviral pathogenesis
- Place of Presentation
  フランス、モンペリエ
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Structure-activity relationship of anti-HIV-1 compound, lamellarin sulfates2011
- Author(s)
  H.Kamiyama, Y.Kubo, H.Sato, N.Yamamoto, T.Fukuda, M.Iwao
- Organizer
  International congress of virology
- Place of Presentation
  札幌
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] XMRV infection alters cellular gene expressions in human prostate cancer LNCaP cells2011
- Author(s)
  K. Kakoki, H. Kamiyama, T. Igawa, H. Sakai, N. Yamamoto, Y. Kubo.
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] XMRV infection alters cellular gene expressions in human prostate cancer LNCaP cells2011
- Author(s)
  K.Kakoki, H.Kamiyama, T.Igawa, H.Sakai, N.Yamamoto, Y.Kubo
- Organizer
  International congress of virology
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] エンドソームに局在する宿主自然免疫因子によるHIV-1増殖抑制2011
- Author(s)
  久保嘉直、神山陽香、鹿子木桂、田中勇悦、林日出喜、松山俊文、佐藤裕徳、山本直樹
- Organizer
  日本エイズ学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] エンドソームに局在する宿主自然免疫因子によるHIV-1増殖抑制2011
- Author(s)
  久保嘉直、神山陽香、鹿子木桂、田中勇悦、林日出喜、松山俊文、佐藤裕徳、山本直樹
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Unprocessed cathepsin L is active in XC cells in which XMRV infection is pH-independent2011
- Author(s)
  Y.Kubo, H.Kamiyama, K.Kakoki, T.Igawa, H.Sakai, N.Yamamoto
- Organizer
  International congress of virology
- Place of Presentation
  札幌
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] XMRVのXC細胞におけるエンドソーム依存性かつ、その酸性化を必要としない感染機構について2010
- Author(s)
  久保嘉直、神山陽香、山本直樹
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Murine leukemia virus in Japanese prostate cancer patients and its cell entry mechanism2010
- Author(s)
  Y.Kubo, H.Kamiyama, T.Matsuyama, N.Yamamoto
- Organizer
  China-Japan International Conference of Virology
- Place of Presentation
  ハルピン、中国、ハルピン医科大学
- Year and Date
  2010-07-05
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] XMRVのXC細胞におけるエンドソーム依存性かつ、その酸性化を必要としない感染機構について2010
- Author(s)
  久保嘉直、神山陽香、山本直樹
- Organizer
  日本ウイルス学会学術総会
- Place of Presentation
  徳島、あわぎんホール
- Year and Date
  2010-11-08
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Murine leukemia virus in Japanese prostate cancer patients and its cell entry mechanism2010
- Author(s)
  Y.Kubo, H.Kamiyama, T.Matsuyama, N.Yamamoto
- Organizer
  Nagasaki-Singapore Medical Symposium on Infectious Diseases
- Place of Presentation
  シンガポール、国立シンガポール大学
- Year and Date
  2010-04-15
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Murine leukemia virus in Japanese prostate cancer patients and its cell entry mechanism.2010
- Author(s)
  Y. Kubo.
- Organizer
  The 8thJapan-China International Conference of Virology
- Place of Presentation
  Harpin, China
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] Tetherin のHIV-1 cell-cell transmission に及ぼす影響2010
- Author(s)
  神山陽香、岩尾正倫、佐藤裕徳、山本直樹、久保嘉直
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] PH-independent activation of endosomal cathepsin proteases induces pH-independent infection by MLV and XMRV2010
- Author(s)
  H.Kamiyama, M.Iwao, N.Yamamoto, Y.Kubo
- Organizer
  Workshop on Retroviral Pathogenesis
- Place of Presentation
  ニューポートビーチ、ロサンジェルス、アメリカ
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] TetherinのHIV-1 cell-cell transmissionに及ぼす影響2010
- Author(s)
  神山陽香、岩尾正倫、佐藤裕徳、山本直樹、久保嘉直
- Organizer
  日本ウイルス学会学術総会
- Place of Presentation
  徳島、あわぎんホール
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] カテプシンBはCD4非依存性HIV感染感受性の重要な決定因子の1つである2010
- Author(s)
  久保嘉直、吉居廣朗、神山陽香、田中勇悦、佐藤裕徳、山本直樹
- Organizer
  日本ウイルス学会学術総会
- Place of Presentation
  徳島、あわぎんホール
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] カテプシンBはCD4非依存性HIV感染感受性の重要な決定因子の1つである2010
- Author(s)
  久保嘉直、吉居廣朗、神山陽香、田中勇悦、佐藤裕徳、山本直樹
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590416
[Presentation] インターフェロンによるレトロウイルス感染抑制に関与する新規細胞性因子の同定
- Author(s)
  久保嘉直、泉田真生、安井潔、林日出喜、松山俊文
- Organizer
  第62回日本ウイルス学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590555

1. 青木義紘 (60817724)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. FUKUDA Tsutomu (80295097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HAYASHI Hideki (10218589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. MATSUYAMA Toshifumi (30165922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 安井潔 (50372777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 高橋健介 (40567294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKASHIMA Tomoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 神山陽香

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 吉居陽香

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 久保裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBO Yoshinao 久保 嘉直

Kubo Yoshinao 久保 嘉直

久保 嘉直 クボ ヨシナオ

Research Projects

Research Products

Co-Researchers

Novel PCR Diagnostic Assay for Enhanced Snakebite Surveillance in the Eastern Visayas, Philippines

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of conditional replication system of Lassa virus glycoprotein-expressing retroviral vectorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic and clinical study on the role of GILT on pathogenicity of bacterial toxins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel host anti-HIV-1 factors using sea lower animalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanism by which an interfeon-gamma-induced, mitochondria-localized novel protein inhibits virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Lamellarin Type Anti-HIV Compoundswith a New Mechanism of Action

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

How does cystatin-C enhance CD4-independent HIV infection?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

レトロウイルスエンベロープ蛋白質による膜融合のシグナル伝達経路Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-22022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unique mode of antiviral action of a marine alkaloid against Ebola virus and SARS-CoV-22022

Author(s)

Journal Title

Data Source

[Journal Article] Antivirus activity, but not thiolreductase activity, is conserved in interferon-gamma-inducible GILT protein in arthropod2021

KUBO Yoshinao 久保嘉直

Kubo Yoshinao 久保嘉直

久保嘉直クボヨシナオ