Hakuno Fumihiko 伯野史彦

… Alternative Names

HAKUNO Fumihiko 伯野史彦

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Researcher Number	30282700
Other IDs
External Links
Affiliation (Current)	2025: 東京大学, 大学院農学生命科学研究科(農学部), 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 大学院農学生命科学研究科(農学部), 准教授 2015 – 2019: 東京大学, 大学院農学生命科学研究科(農学部), 助教 2017: 東京大学, 大学院農学生命科学研究科, 助教 2011 – 2015: 東京大学, 農学生命科学研究科, 助教 2013 – 2014: 東京大学, 大学院農学生命科学研究科, 助教 … More 2013: 東京大学, 大学院農学生命科学研究科(農学部), 助教 2007 – 2012: The University of Tokyo, Graduate School of Agriculture and Life Sciences, Assistant Professor 2006: 東京大学, 大学院農学生命科学研究科, 助手 1997 – 2005: 東京大学, 大学院・農学生命科学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Applied animal science / Basic Section 42030:Animal life science-related / Animal production science / Applied animal science Except Principal Investigator Animal production science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Applied animal science / Applied animal science / Basic Section 38060:Applied molecular and cellular biology-related / Basic Section 47060:Clinical pharmacy-related / Pediatrics
Keywords	Principal Investigator インスリン / 糖尿病 / アミノ酸シグナル / 脂質代謝 / ジアシルグリセロールキナーゼ / インスリン受容体基質(IRS) / 細胞内情報伝達経路 / 糖代謝 / アミノ酸 / 選択的スプライシング … More / 糖脂質代謝 / オルニチンシグナル / 代謝制御性アミノ酸シグナル / オルニチン / エネルギー分配 / アミノ酸栄養 / シグナル伝達 / 生理活性 / mTOR / IGF / 臓器特異的脂肪蓄積 / アミノ酸欠乏食 / 畜産学 / 応用動物 / 栄養学 / 人工知能 / 機械学習 / インスリン様成長因子 / 筋脂肪交雑 / 脂肪肝 / 脂肪合成 / アミノ酸代謝 / 糖取り込み / 2型糖尿病 / 細胞膜移行 / 糖輸送担体（GLUT4) / PIP5K / 高糖尿病薬 / ジアシルグリセロールキナーゼζ / インスリン受容体基質 / ジアルシグリセロールキナーゼ / 低分子化合物 / インスリン抵抗性 / 糖輸送担体 / PI3-kinase / PITKAP / 細胞増殖 / PI3KAP / PI 3-kinase / IGF-I / IRS / 脂質 / DGKζ / 細胞内シグナル伝達 / Glucose transporter(Glut4) / 脂肪細胞 / インスリン抵抗 / ジアシルグリセロール / 情報伝達 / cAMP経路 / differential display / インスリン様成長因子I / cAMP / 情報のクロストーク / チロシンキナーゼ / インスリン様成長因子^I … More Except Principal Investigator インスリン受容体基質 / インスリン様成長因子 / 代謝・内分泌制御 / インスリン / cAMP / 細胞内シグナル伝達 / インスリン様活性 / アミノ酸 / チロシンリン酸化 / スプライシング / 増殖 / 細胞内シグナル / インスリン受容体基質（IRS） / インスリン様シグナル / インスリン受容体 / tyrosine phosphorylation / insulin-like growth factor / チロシンキナーゼ / 細胞増殖 / シグナルクロストーク / トロピックホルモン / RNA / 翻訳 / がん / 糖尿病 / インスリン様成長因子受容体 / ユビキチンリガーゼ / 脱ユビキチン化酵素 / 代謝制御性アミノ酸シグナル / 代謝制御 / 転写後調節 / 選択的スプライシング / RNAスプライシング / 内分泌 / インスリン様成長因子（IGF） / モデリング＆シミュレーション / メタボローム / 脂肪酸 / メタボロミクス / 糖尿病合併症 / メタボリックメモリー / ユビキチン化 / 筋分化 / 代謝調節 / 代謝・内分泌 / 内分泌学 / 小児科学 / 遺伝子 / GH-IGF系経路 / IGF1R / GH-IGFシグナル / 成長障害 / 小児内分泌学 / proteomics / two-hybrid screening / insulin receptor substrates / signal transduction / insulin / ツーハイフリッドスクリーニング / サイトカイン / プロテオミクス / ツーハイブリッドスクリーニング / kinase / cell growth / intracellular signal / signal cross-talk / tropic hormone / Tyrosine kinase / Proliferation / Tyrosine phosphorylation / Intracellular signaling / Signal closstalk / Tropic hormone / Insulin-like growth factors / クロストーク / ＲＮＡ / リボソーム合成 / 成長異常 / インスリン抵抗性 / 糖取り込み / アダプタータンパク質 / ユビキチン化酵素 Less

Regulation of insulin-like activities using signaling complexes formed by RNA and IRS-1.
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
Elucidation of post-transcriptional regulation mechanism regulated by amino-acid metabolic signal
- Principal Investigator
  
  片岡直行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  The University of Tokyo
メタボロミクスによるメタボリックメモリーの推算と糖尿病合併症予防・治療への応用
- Principal Investigator
  
  鬼木健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kumamoto University
生体の糖脂質代謝スイッチを誘導するオルニチン情報伝達経路の同定とその制御Principal Investigator
- Principal Investigator
  
  伯野史彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  The University of Tokyo
Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
Elucidation of mechanism for short stature with abnormal GH-IGF signaling
- Principal Investigator
  
  KAWASHIMA YUKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Tissue specific lipid accumulation in response to amino acid signalPrincipal Investigator
- Principal Investigator
  
  Hakuno Fumihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significance
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
動物の一生において時期・組織特異的にインスリン様活性を制御する新規機構とその意義
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Identification and elucidation of the roles of RNAs associated with insulin receptor substrate
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Analysis of insulin resistance through DGKz and development of anti-diabetic medicinePrincipal Investigator
- Principal Investigator
  
  Hakuno Fumihiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Novel mechanisms of growth regulation through changes in ubiquitination of insulin receptor substrates
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Molecular mechanism underlying cAMP-induced amplification of IGF mitogenic activity through PI3-kinase binding protein, PI3KAP/XB130.Principal Investigator
- Principal Investigator
  
  HAKUNO Fumihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Clearance of insulin resistance by inhibiting diacylglycerol kinaseζ activityPrincipal Investigator
- Principal Investigator
  
  HAKUNO Fumihiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
ジアシルグリセロールキナーゼ(DGK)ζによるインスリン活性の新しい修飾機構Principal Investigator
- Principal Investigator
  
  伯野史彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Novel Molecular Mechanisms Underlying Modulation of Insulin-Like Activities
- Principal Investigator
  
  TAKAASHI Shin-ichiro
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Cross-talk regulatory proteins that function for potentiation of IGF signals in stage-and tissue-specific manners
- Principal Investigator
  
  TAKAHASHI Shin-ichiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
New perspectives of the molecular mechanisms to potentiate IGF signals
- Principal Investigator
  
  TAKAHASHI Shin-ichiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Applied animal science
- Research Institution
  THE UNIVERSITY OF TOKYO
インスリン様成長因子^Iの生理活性を増強するcAMP依存性チロシンキナーゼの探索Principal Investigator
- Principal Investigator
  
  伯野史彦
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo

[Book] Progress in Molecular Biology and Translational Science2016
- Author(s)
  Girnita L, Takahashi S-I, Crudden C, Fukushima T, Worrall C, Furuta H, Yoshihara H, Hakuno F, Girnita A.
- Total Pages
  34
- Publisher
  Elsevier Inc
- Data Source
  KAKENHI-PROJECT-25221204
[Book] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Total Pages
  11
- Publisher
  化学と生物
- Data Source
  KAKENHI-PROJECT-24380152
[Book] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Total Pages
  8
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-24380152
[Book] 発達と成長を司るホルモン、インスリン様成長因子2010
- Author(s)
  高橋伸一郎、竹中麻子、豊島由香、木村久美、加藤久典、福嶋俊明、山中大介、伯野史彦、南史朗、岩下光利
- Publisher
  日本未熟児新生児学会雑誌
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] 1.Growth hormone resistance induced by amino acid deprivation in fao cells is independent of FGF21.2024
- Author(s)
  Saito M., Nishi H., Takahashi SI., Hakuno F., Miyata I.
- Journal Title
  
  Biochem. Biophys Res. Commun.
  
  Volume: 709 Pages: 149811-149811
- DOI
  10.1016/j.bbrc.2024.149811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23793
[Journal Article] The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC32023
- Author(s)
  Furuta Haruka、Sheng Yina、Takahashi Ayaka、Nagano Raku、Kataoka Naoyuki、Perks Claire Marie、Barker Rachel、Hakuno Fumihiko、Takahashi Shin-Ichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 20 Pages: 15065-15065
- DOI
  10.3390/ijms242015065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00358, KAKENHI-PROJECT-23K23793
[Journal Article] 人類はこれからどのような食生活をしていくべきか2023
- Author(s)
  高橋伸一郎、宮本崇史、潮秀樹、山中大介、増田正人、伯野史彦、勝俣昌也、太田与洋
- Journal Title
  
  明日の食品産業
  
  Volume: 538 Pages: 42-49
- Data Source
  KAKENHI-PROJECT-23H00358
[Journal Article] Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age2023
- Author(s)
  Kondo Yoshitaka、Aoki Hitoshi、Masuda Masato、Nishi Hiroki、Noda Yoshihiro、Hakuno Fumihiko、Takahashi Shin-Ichiro、Chiba Takuya、Ishigami Akihito
- Journal Title
  
  GeroScience
  
  Volume: 45 Issue: 4 Pages: 2707-2726
- DOI
  10.1007/s11357-023-00797-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05485, KAKENHI-PROJECT-23K23793, KAKENHI-PROJECT-23K24804
[Journal Article] Essential Amino Acid Intake Is Required for Sustaining Serum Insulin‐Like Growth Factor‐I Levels but Is Not Necessarily Needed for Body Growth2022
- Author(s)
  Nishi H, Uchida K, Saito M, Yamanaka D, Nagata H, Tomoshige H, Miyata I, Ito K, Toyochima Y, Takahashi S-I, Hakuno F, Takenaka A
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 9 Pages: 1523-1523
- DOI
  10.3390/cells11091523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-21K14826, KAKENHI-PROJECT-22K05488, KAKENHI-PROJECT-19H02916, KAKENHI-PROJECT-23K23793
[Journal Article] 【解説】進化から学ぶインスリン様ペプチドシステムの生理的意義：動物の一生の健康を司る同化ホルモン2022
- Author(s)
  高橋伸一郎、亀井宏泰、富岡征大、清家瞳、永田晋治、尾添淳文、伯野史彦
- Journal Title
  
  化学と生物
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] アミノ酸の一種、オルニチンが糖代謝遺伝子発現を制御する2022
- Author(s)
  西宏起, 高橋伸一郎伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] A Novel Amino Acid Signaling Mediated by Ornithine Governs Glucose-6-phosphatase Transcription2021
- Author(s)
  Fukushima S, Nishi H, Kumano M, Yamanaka D, Kataoka N, Hakuno F, Takahashi S-I
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 7 Pages: 102778-102778
- DOI
  10.1016/j.isci.2021.102778
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells2021
- Author(s)
  Nakura T, Ozoe A, Narita Y, Matsuo M, Hakuno F, Kataoka N, Takahashi S-I
- Journal Title
  
  Biochimie
  
  Volume: 187 Pages: 25-32
- DOI
  10.1016/j.biochi.2021.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats2021
- Author(s)
  Goda Y, Yamanaka D, Nishi H, Masuda M, Kamei H, Kumano M, Ito K, Katsumata M, Yamanouchi Y, Kataoka N, Hakuno F, Takahashi S-I
- Journal Title
  
  J Biol Chem
  
  Volume: 197 Issue: 4 Pages: 101179-101191
- DOI
  10.1016/j.jbc.2021.101179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] 血中アミノ酸プロファイル変動を利用した新しい脂肪肝の改善法2021
- Author(s)
  伯野史彦、西宏起、山中大介、増田正人、高橋伸一郎
- Journal Title
  
  （実験医学増刊）「個人差の理解へ向かう肥満研究」
  
  Volume: 39 Pages: 817-822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] Endogenous testosterone reduces hepatic lipid accumulation in protein-restricted male rats.2021
- Author(s)
  Uchida K, Inoue K, Hasegawa Y, Hakuno F, Takahashi SI, Takenaka A
- Journal Title
  
  Nutrition
  
  Volume: 85 Pages: 111130-111130
- DOI
  10.1016/j.nut.2020.111130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation2020
- Author(s)
  Okino Ryosuke、Usui Ami、Yoneyama Yosuke、Takahashi Shin-Ichiro、Hakuno Fumihiko
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 11 Pages: 1-10
- DOI
  10.3389/fendo.2020.00096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16536, KAKENHI-PROJECT-18H03972
[Journal Article] Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes2020
- Author(s)
  Hase Katsunori、Contu Viorica Raluca、Kabuta Chihana、Sakai Ryohei、Takahashi Masayuki、Kataoka Naoyuki、Hakuno Fumihiko、Takahashi Shin-Ichiro、Fujiwara Yuuki、Wada Keiji、Kabuta Tomohiro
- Journal Title
  
  Autophagy
  
  Volume: NO Issue: 11 Pages: 1-15
- DOI
  10.1080/15548627.2020.1712109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-17K07124, KAKENHI-PROJECT-16H05146, KAKENHI-PROJECT-18F18384, KAKENHI-PROJECT-20J00363, KAKENHI-PLANNED-19H05710
[Journal Article] Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences2019
- Author(s)
  Masaki So、Ikeda Shun、Hata Asuka、Shiozawa Yusuke、Kon Ayana、Ogawa Seishi、Suzuki Kenji、Hakuno Fumihiko、Takahashi Shin-Ichiro、Kataoka Naoyuki
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 10 Pages: 1-8
- DOI
  10.3389/fgene.2019.00338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06012, KAKENHI-PROJECT-18K16084, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18H03972
[Journal Article] インスリン様シグナルと代謝制御性アミノ酸シグナル：次世代栄養学『AI Nutrition』の提唱2019
- Author(s)
  高橋伸一郎、伯野史彦、山中大介、中林靖、豊島由香、竹中麻子
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 514-520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.2018
- Author(s)
  Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
- Journal Title
  
  Oncotarget
  
  Volume: 9(74) Issue: 74 Pages: 33871-33883
- DOI
  10.18632/oncotarget.26049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-15J10937, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26221204
[Journal Article] 解説アミノ酸の新機能：血中プロファイルに応じた脂質代謝の変動2018
- Author(s)
  西宏起、伯野史彦、高橋伸一郎
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 76 Pages: 467-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] 成長ホルモンは，実は「異化ホルモン」である2018
- Author(s)
  高橋伸一郎、伯野史彦
- Journal Title
  
  成長代謝
  
  Volume: 9 Pages: 1-4
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] IGF-I receptor signaling pathways2018
- Author(s)
  Hakuno F, Takahashi SI.
- Journal Title
  
  J. Mol. Endocrinol.
  
  Volume: - Issue: 1 Pages: T69-T86
- DOI
  10.1530/jme-17-0311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-25221204
[Journal Article] Serine phosphorylation by mTORC1 promotes IRS-1 degradation through SCF-b-TRCP E3 ubiquitin ligase2018
- Author(s)
  Yoneyama Y, Inamitsu T, Chida K, Iemura SI, NatsumeT, Maeda T, Hakuno F, Takahashi S-I
- Journal Title
  
  iScience
  
  Volume: 5 Pages: 1-18
- DOI
  10.1016/j.isci.2018.06.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-17H03802, KAKENHI-PROJECT-25221204
[Journal Article] IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling2018
- Author(s)
  Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI
- Journal Title
  
  Elife
  
  Volume: 7
- DOI
  10.7554/elife.32893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-25221204
[Journal Article] 解説アミノ酸の新機能：血中プロファイルに応じた脂質代謝の変動2018
- Author(s)
  西宏起、伯野史彦、高橋伸一郎
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 76 Pages: 467-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] 成長ホルモンは，実は「異化ホルモン」である2018
- Author(s)
  高橋伸一郎、伯野史彦
- Journal Title
  
  成長代謝
  
  Volume: 9 Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein Malnutrition2018
- Author(s)
  Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Yasushi Nakabayashi, Ryuji Shioya, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Journal Title
  
  Nature, Scientific Report
  
  Volume: 8:5461 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-018-23640-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26390134, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-16J08326, KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-18K06014, KAKENHI-PROJECT-16K07747
[Journal Article] Glucose deprivation attenuates sortilin levels in skeletal muscle cells2017
- Author(s)
  Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi S
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: 3 Pages: 255-268
- DOI
  10.1507/endocrj.EJ16-0319
- NAID
  130005529466
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats2017
- Author(s)
  Horiuchi Mami、Takeda Tomoya、Takanashi Hiroyuki、Ozaki-Masuzawa Yori、Taguchi Yusuke、Toyoshima Yuka、Otani Lila、Kato Hisanori、Sone-Yonezawa Meri、Hakuno Fumihiko、Takahashi Shin-Ichiro、Takenaka Asako
- Journal Title
  
  Nutrition & Metabolism
  
  Volume: 14 Issue: 1 Pages: 59-59
- DOI
  10.1186/s12986-017-0215-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07747, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-16K18706
[Journal Article] The short-stature homeobox-containing gene (shox/SHOX) is required for the regulation of cell proliferation and bone differentiation in zebrafish embryo and human mesenchymal stem cells.2017
- Author(s)
  Yokokura T, Kamei H, Shibano T, Yamanaka D, Sawada-Yamaguchi R, Hakuno F, Takahashi SI, Shimizu T
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: -
- DOI
  10.3389/fendo.2017.00125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04583
[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.2017
- Author(s)
  Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 484 Issue: 3 Pages: 522-528
- DOI
  10.1016/j.bbrc.2017.01.101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes2016
- Author(s)
  Liu TY, Yu BC, Kakino M, Fujimoto H, Ando Y, Hakuno F, Takahashi S-I
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 35438-35438
- DOI
  10.1038/srep35438
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2016
- Author(s)
  高橋伸一郎、福嶋俊明、安藤康年、伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 21-25
- NAID
  40020705836
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling2016
- Author(s)
  L Girnita, S-I Takahashi, C Crudden, T Fukushima, C Worrall, H Furuta, H Yoshihara, F Hakuno, A Girnita
- Journal Title
  
  Progress in Molecular Biology and Translational Science
  
  Volume: 141 Pages: 277-311
- DOI
  10.1016/bs.pmbts.2016.04.001
- ISBN
  9780128093863
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-25221204
[Journal Article] Study of effects of blood amino acidand hormone level for controlling triglyceride accumulation in the liver of rats using Self-Organizing Map2016
- Author(s)
  Masato Masuda, Yasushi Nakabayashi, Ryuji Shioya, Hiroki Nishi, Shin-Ichiro Takahashi, Fumihiko Hakuno
- Journal Title
  
  International Journal of Intelligent Information Systems
  
  Volume: 5 Issue: 6 Pages: 88-93
- DOI
  10.11648/j.ijiis.20160506.12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J08326, KAKENHI-PROJECT-26390134, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] Phosphatidylinositol 3-Kinase-associated Protein (PI3KAP)/XB130 Crosslinks actin Filaments through its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 cells2016
- Author(s)
  Daisuke Yamanaka, Takeshi Akama, Kazuhiro Chida, Shiro Minami, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Journal Title
  
  frontiers in Endocrinology
  
  Volume: 7 Pages: 89-89
- DOI
  10.3389/fendo.2016.00089
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18812, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2016
- Author(s)
  高橋伸一郎、福嶋俊明、安藤康年、伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 21-25
- NAID
  40020705836
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14840
[Journal Article] アミノ酸シグナルを利用した高品質食資源の開発技術の確立2016
- Author(s)
  高橋伸一郎、潮秀樹、加藤久典、伯野史彦、柴田重信、竹中麻子、豊島由香、勝俣昌也、中島一喜
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 4 Pages: 4-4
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.2016
- Author(s)
  Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi S, Yamanouchi K, Nishihara M
- Journal Title
  
  Experimental Cell Research
  
  Volume: 347 Issue: 2 Pages: 367-377
- DOI
  10.1016/j.yexcr.2016.08.023
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J08006, KAKENHI-PROJECT-25292185, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-16H05041
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Journal Title
  
  Nature communications
  
  Volume: 6 Issue: 1 Pages: 6780-6780
- DOI
  10.1038/ncomms7780
- NAID
  120006348510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014
[Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2015
- Author(s)
  高橋伸一郎、福嶋俊明、安藤泰年、伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 21-25
- NAID
  40020705836
- Data Source
  KAKENHI-PROJECT-15H04583
[Journal Article] The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins2015
- Author(s)
  Hakuno F, Fukushima T, Yoneyama Y, Kame H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu B-C, Chida K, Takahashi S-I
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: なし
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25660210
[Journal Article] Analysis of insulin receptor substrates signaling dynamics on microstructured surfaces.2015
- Author(s)
  Lanzerstorfer P, Yoneyama Y, Hakuno F, Muller U, Hoglinger O, Takahashi SI, Weghuber J
- Journal Title
  
  FEBS J.
  
  Volume: 282 Issue: 6 Pages: 987-1005
- DOI
  10.1111/febs.13213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-25221204
[Journal Article] The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins.2015
- Author(s)
  Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S.
- Journal Title
  
  Front Endocrinol (Lausanne).
  
  Volume: 6 Pages: 73-73
- DOI
  10.3389/fendo.2015.00073
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-15K18799, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204
[Journal Article] Rapid increase in fibroblast growth factor 2 in protein malnutrition and its impact on growth and lipid metabolism.2015
- Author(s)
  Yori Ozaki, Kenji Saito, Kyoko Nakazawa, Morichika Konishi, Nobuyuki Itoh, Fumihiko Hakuno, Shin-Ichiro Takahashi, Hisanori Kato and Asako Takenaka
- Journal Title
  
  British Journal of Nutrition
  
  Volume: 114 Issue: 9 Pages: 1410-1418
- DOI
  10.1017/s0007114515002846
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-26460084, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-25221204
[Journal Article] Tumor Necrosis Factor (TNF)-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-I Causes Insulin Resistance in 3T3-L1 Adipocytes2015
- Author(s)
  Ando Y, Shinozawa Y, Iijima Y, Yu B-C, Sone M, Ooi Y, Watanaka Y, Chida K, Hakuno F, Takahashi S-I
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 9 Pages: 5881-5892
- DOI
  10.1074/jbc.m114.624759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03089, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] In vivo loss of function study reveals the short stature homeobox-containing (shox) gene plays indispensable roles in early embryonic growth and bone formation in zebrafish.2015
- Author(s)
  Sawada R., Kamei H., Hakuno F., Takahashi S., Shimizu T.
- Journal Title
  
  Dev. Dyn.
  
  Volume: 244 Issue: 2 Pages: 146-156
- DOI
  10.1002/dvdy.24239
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-25221204
[Journal Article] Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growting rats.2014
- Author(s)
  Toyoshima Y, Tokita R, Taguchi Y, Akiyama-Akanishi N, Takenaka A, Kato H, Chida K, Hakuno F, Minami S, Takahashi S-I.
- Journal Title
  
  Endocrine J.
  
  Volume: 61 Pages: 499-512
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.2014
- Author(s)
  Liu C, Luan J, Bai Y, Li Y, Lu L, Liu Y, Hakuno F, Takahashi S, Duan C, Zhou J.
- Journal Title
  
  Gen Comp Endocrinol
  
  Volume: 197 Pages: 82-91
- DOI
  10.1016/j.ygcen.2013.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204
[Journal Article] Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters.2014
- Author(s)
  Kaneko M, Hakuno F, Kamei H, Yamanaka D, Chida K, Minami S, Coe RI, Takahashi S-I.
- Journal Title
  
  Bicohem Biophysic Res Commun.
  
  Volume: 443 Issue: 2 Pages: 505-510
- DOI
  10.1016/j.bbrc.2013.11.132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25850220
[Journal Article] Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver2014
- Author(s)
  Yokota S-I, Nakamura K, Ando M, Kamei H, Hakuno F, Takahashi S-I, Shibata S. 2014 Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Issue: 1 Pages: 905-914
- DOI
  10.1016/j.fob.2014.10.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.2014
- Author(s)
  Yori Ozaki, Tomoya Takeda, Narumi Akanishi, Fumihiko Hakuno, Yuka Toyoshima, Shin-Ichiro Takahashi & Asako Takenaka
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: - Issue: 1 Pages: 130-138
- DOI
  10.1080/09168451.2014.877825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580202, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25850095
[Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.2014
- Author(s)
  Ozoe A, Sone M, Fukushima T, Kataoka N, Chida K, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 5 Pages: 24-24
- DOI
  10.3389/fendo.2014.00024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25660210
[Journal Article] Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats2014
- Author(s)
  Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Narumi Akiyama-Akanishi, Asako Takenaka, Hisanori Kato, Kazuhiro Chida, Fumihiko Hakuno, Shiro Minami, Shin-Ichiro Takahashi
- Journal Title
  
  Endocr J
  
  Volume: 61 Issue: 5 Pages: 499-512
- DOI
  10.1507/endocrj.EJ13-0514
- NAID
  130004443967
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25850095, KAKENHI-PROJECT-25221204
[Journal Article] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 934-941
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Insulin Receptor Substrate-1 (IRS-1) Forms a Ribonucleoprotein Complex Associated with Polysomes2013
- Author(s)
  Ozoe A, Sone M, Fukushima T, Kataoka N, Arai T, Chida K, Asano T, Hakuno F, Takahashi S-I
- Journal Title
  
  FEBS Lett.
  
  Volume: 587(15) Issue: 15 Pages: 2319-24
- DOI
  10.1016/j.febslet.2013.05.066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25660210
[Journal Article] Insulin injection restores increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but does not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.2013
- Author(s)
  Ozaki Y, Takeda T, Akiyama-Akanishi N, Hakuno F, Toyoshima Y, Takahashi S-I, Takenaka A.
- Journal Title
  
  Biosci. Biotech. Biochem.
  
  Volume: 79 Issue: 1 Pages: 47-53
- DOI
  10.1007/s12562-012-0570-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152
[Journal Article] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25660210
[Journal Article] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 934-941
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] 解説:インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- URL
  http://www.jsbba.or.jp/pub/journal_kasei/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent cell proliferation2013
- Author(s)
  Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi SI,
- Journal Title
  
  Mol. Cell. Biol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152
[Journal Article] The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation2013
- Author(s)
  Yosuke Yoneyama
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: Volume 33 Issue: 10 Pages: 1991-2003
- DOI
  10.1128/mcb.01394-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07756, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25252047
[Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 934-941
- Data Source
  KAKENHI-PROJECT-25660210
[Journal Article] Phosphatidylinsitol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.2012
- Author(s)
  Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 35 Pages: 29713-29721
- DOI
  10.1074/jbc.m112.393074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] Kanzaki Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation Clin2012
- Author(s)
  Kawashima Y, Higaki K, Fukushima T, Hakuno F, Nagaishi JI, Hanaki K, Nanba E, Takahashi SI
- Journal Title
  
  Endocrinol
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells2012
- Author(s)
  Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S
- Journal Title
  
  Mol.Endocrinology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Nexjlin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.2012
- Author(s)
  Lee A, Hakuno F, Northcott P, Pessin JE, Rozakis Adcock M
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: e55634-e55634
- DOI
  10.1371/journal.pone.0055634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152
[Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans2012
- Author(s)
  Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi S
- Journal Title
  
  Growth Horm. IGF Res
  
  Volume: 22 Pages: 64-68
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation2012
- Author(s)
  Kawashima Y, Higaki K, Fukushima T, Hakuno F, Nagaishi JI, Hanaki K, Nanba E, Takahashi SI, Kanzaki S
- Journal Title
  
  Clin.Endocrinol.
  
  Volume: (in press) Issue: 2 Pages: 246-54
- DOI
  10.1111/j.1365-2265.2012.04357.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-21591324, KAKENHI-PROJECT-22591128, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-24591512, KAKENHI-PROJECT-24790928
[Journal Article] Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs2012
- Author(s)
  Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S-I
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 423 Issue: 1 Pages: 122-127
- DOI
  10.1016/j.bbrc.2012.05.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22687009, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans2012
- Author(s)
  Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi S, Takahashi Y
- Journal Title
  
  Growth Horm.IGF Res.
  
  Volume: 22 Issue: 2 Pages: 64-68
- DOI
  10.1016/j.ghir.2012.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells2012
- Author(s)
  Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi
- Journal Title
  
  Mol. Endocrinology
  
  Volume: 26 Pages: 1043-1055
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article]2012
- Author(s)
  Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H.
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 2275-95
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Novel repressor regulates insulin sensitivity through interaction with Foxo12012
- Author(s)
  Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi SI, Itoh H
- Journal Title
  
  EMBO J.
  
  Volume: 31 Issue: 10 Pages: 2275-2295
- DOI
  10.1038/emboj.2012.97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24650442, KAKENHI-PUBLICLY-24116507
[Journal Article] HSP90 interacting with IRS-2 is involved in camp-dependent potentiation of IGF-I signals in FRTL-5 cells2011
- Author(s)
  Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida M, Asano T, Chida K, Hakuno F, Takahashi S-I.
- Journal Title
  
  Mol. Cell Endocrinol.
  
  Volume: 344 Pages: 81-89
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Constitutive expression of insulin receptor substrate(IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts2011
- Author(s)
  Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi S
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 10 Pages: e25655-e25655
- DOI
  10.1371/journal.pone.0025655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248027, KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780190, KAKENHI-PROJECT-23658174
[Journal Article] KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells2011
- Author(s)
  Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, Takahashi S-I, Ohno S, Chida K.
- Journal Title
  
  Curr. Biol
  
  Volume: 21 Pages: 705-711
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases2011
- Author(s)
  Fukushima T, Arai T, Ariga-Nedachi M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 404 Pages: 767-773
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011
- Author(s)
  Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida H, Asano T, Chida K
- Journal Title
  
  Mol.Cell Endocrinol.
  
  Volume: 344 Issue: 1-2 Pages: 81-90
- DOI
  10.1016/j.mce.2011.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases2011
- Author(s)
  Fukushima T, Arai T, Ariga M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Hakuno F, Takahashi S-I
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Issue: 3 Pages: 767-773
- DOI
  10.1016/j.bbrc.2010.12.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] PKC promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions2011
- Author(s)
  Hara T, Miyazaki M, Hakuno F, Takahashi S-I, Chida K.
- Journal Title
  
  Cell Death Dis
  
  Volume: 2
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] KIBRA suppresses apical exocytosis through inhibition of aPKC activity in epithelial cells2011
- Author(s)
  Yohei Yoshihama
- Journal Title
  
  Current Biology
  
  Volume: 21 Issue: 8 Pages: 705-711
- DOI
  10.1016/j.cub.2011.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J05317, KAKENHI-PLANNED-21116004, KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22247030, KAKENHI-PROJECT-23790379
[Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinase.2011
- Author(s)
  Fukushima T. Hakuno F, et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 404 Pages: 767-773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] PKC I promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions2011
- Author(s)
  Hara T, Miyazaki M, Hakuno F, Takahashi S, Chida K
- Journal Title
  
  Cell Death Dis.
  
  Volume: 2 Issue: 5 Pages: e157-e157
- DOI
  10.1038/cddis.2011.40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Constitutive expression of insulin receptor substrate(IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts2011
- Author(s)
  Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi S-I
- Journal Title
  
  PLos One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression2010
- Author(s)
  Kimura K, Katsumata Y, Ozawa T, Tawara S, Igarashi K, Cho Y, Shibata N, Hakuno F, Takahashi SI, Takenaka A
- Journal Title
  
  J.Clin.Biochem.Nutr. 46
  
  Pages: 157-167
- NAID
  130004466606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity2010
- Author(s)
  Kabuta T, Hakuno F, Cho Y, Yamanaka D, Chida K, Asano T, Wada K, Takahashi SI
- Journal Title
  
  Biochem.Biophys.Res.Commun. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression2010
- Author(s)
  Kimura K, Katsumata Y, Ozawa T, Tawara S, Igarashi K, Cho Y, Shibata N, Hakuno F, Takahashi S-I, Takenaka A.
- Journal Title
  
  J. Clin. Biochem. Nutr
  
  Volume: 46 Pages: 157-167
- NAID
  130004466606
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver2010
- Author(s)
  Toyoshima Y, Tokita R, Ohne Y, Hakuno F, Noguchi T, Minami S, Kato H, Takahashi S-I.
- Journal Title
  
  J. Mol. Endocrinol.
  
  Volume: 45 Pages: 329-340
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver.2010
- Author(s)
  Toyoshima Y, Hakuno F, et al.
- Journal Title
  
  J. Mol. Endocrinol.
  
  Volume: 45 Pages: 329-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.2010
- Author(s)
  Shibata M, Hakuno F, et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 20915-20925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity2010
- Author(s)
  Kabuta T, Hakuno F, Cho Y, Yamanaka D, Chida K, AsanoT, Wada K, Takahashi S-I.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 394 Pages: 697-702
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes2010
- Author(s)
  Shibata M, Hakuno F, Yamanaka D, Okajima H, Fukushima T, Hasegawa T, Ogata T, Toyoshima Y, Chida K, Kimura K, Sakoda H, Takenaka A, Asano T, Takahashi S-I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 20915-25
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] Growth hormone(GH) and Insulin-like growth factor(IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1(HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates2009
- Author(s)
  Morita J, Hakuno F, Hizuka N, Takahashi S-I, Takano K.
- Journal Title
  
  Endocrine J.
  
  Volume: 56 Pages: 561-570
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] GHinhibition of glucose uptake inadipocytes occurs without affectingGLUT4-translocation through anIRS-2-PI-3-kinase-dependent pathway2009
- Author(s)
  Naoko Sasaki-Suzuki, Kiyoshi Arai,Tomomi Ogata, Kouhei Kasahara, HideyukiSakoda, Kazuhiro Chida, TomoichiroAsano, Jeffrey E. Pessin, FumihikoHakuno, Shin-Ichiro Takahashi
- Journal Title
  
  J.Biol. Chem 284
  
  Pages: 6061-6070
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] GH or IGF-I represses 11beta-hydroxysteroid dehydrogenase type 1(HSD1)mRNA expression in 3T3-L1 and its activity in their homogenates.2009
- Author(s)
  Morita J, Hakuno F, Hizuka N, Takahashi SI, Takano K
- Journal Title
  
  Endocrine Journal 56
  
  Pages: 561-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345
[Journal Article] 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling2008
- Author(s)
  Hakuno F, et. al.
- Journal Title
  
  Endocrinology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Journal Article] Distinct Modes of Activation ofPhosphatidylinositol 3-kinase inResponse to cAMP or IGF-I PlayDifferent Roles in Regulation of CyclinD1 and p27Kip1 in FRTL-5 Cells2008
- Author(s)
  Fukushima T., Nedachi T., Akizawa H., Hakuno F. and Takahashi S-I
- Journal Title
  
  Endocrinology 149
  
  Pages: 3729-3742
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] Distinct modes of activation of PI 3-kinase in response to cAMP or IGF-I play differentroles in regulation of cyclin Dl and p27Kipl in FRTL-5 cells2008
- Author(s)
  Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F,Takahashi S-I
- Journal Title
  
  Endocrinology 149
  
  Pages: 3729-3742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] Differentialsubcellular localization of insulinreceptor substrates depends onC-terminal regions and importin beta2008
- Author(s)
  Kabuta T, Take K, Kabuta C, Hakuno F, and Takahashi S-I
- Journal Title
  
  Biochem. Biophys. Res. Commun 377
  
  Pages: 741-741
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] Identification ofBombyx mori Akt and its phosphorylationby bombyxin stimulation2008
- Author(s)
  Nagata S. Hakuno F. Takahashi S-I. and Nagasawa H
- Journal Title
  
  Comp Biochem. Physiol. B Biochem Mol. Biol 151
  
  Pages: 355-360
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] Distinct modes of activation of phosphatidylinositol 3-kinase in response to cAMP or IGF-I play different roles in regulation of Cyclin D1 and p27 Kip1 in FRTL-5 cells.2008
- Author(s)
  Fukushima T., Nedachi T., Akizawa H., Akahori M., Hakuno F., Takahashi S.I.
- Journal Title
  
  Endocrinology (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta.2008
- Author(s)
  Kabuta T, Take K, Kabuta C, Hakuno F, Takahashi S-I
- Journal Title
  
  Biochem. Biophys. Res. Commun 377
  
  Pages: 741-746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] 53BP2S, interacting with insulin receptor substrates, modulates insulin signals.2007
- Author(s)
  Hakuno F, Kurihara S, Watson RT, Pessi
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 37747-37758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] 53BP2, interacting with insulin receptor substrates, modulates insulin signaling2007
- Author(s)
  Hakuno F
- Journal Title
  
  J Biol Chem 282
  
  Pages: 37747-37758
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16208028
[Journal Article] 53BP2,interacting with insulin receptor substrates,modulates insulin signaling2007
- Author(s)
  Hakuno F, et. al.
- Journal Title
  
  J.Biol.Chem 282
  
  Pages: 37747-37758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16208028
[Journal Article] The Novel Roles of Liver for Compensation of Insulin Resistance in Human Growth Hormone Transgenic Rats2006
- Author(s)
  Cho Y, Ariga M, Uchijima Y, Kimura K, Rho JY, Furuhata Y, Hakuno F, Yamanouchi K, Nishihara M, Takahashi S-I
- Journal Title
  
  Endocrinology 174(11)
  
  Pages: 5374-5384
- Data Source
  KAKENHI-PROJECT-17780209
[Journal Article] Growth hormon (GH) andInsulin-like growth factor (IGF)-Irepresses 11beta-hydroxysteroiddehydrogenase type 1 (HSD1) mRNAexpression in 3T3-L1 cells and itsactivity in their homogenates
- Author(s)
  Junko Morita, Fumihiko Hakuno, NaomiHizuka, Shin-Ichiro Takahashi, KazueTakano
- Journal Title
  
  Endocrine J (In press)
- Data Source
  KAKENHI-PROJECT-19580324
[Journal Article] IGFが特定の生理活性を発現する分子メカニズム-IGF細胞内シグナル伝達系の特徴とその生理的意義-
- Author(s)
  福嶋俊明, 伯野史彦, 高橋伸一郎
- Journal Title
  
  ホルモンと臨床 (In Press)
- NAID
  10019499595
- Data Source
  KAKENHI-PROJECT-17780209
[Patent] Method for regulation of lipid metabolism in liver2023
- Inventor(s)
  Fumihiko Hakuno
- Industrial Property Rights Holder
  Fumihiko Hakuno
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K23793
[Patent] 血中アミノ酸プロファイルを改変する食の開発2023
- Inventor(s)
  伯野史彦、山中大介、髙橋伸一郎、増田正人
- Industrial Property Rights Holder
  伯野史彦
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 筋芽細胞におけるアミノ酸シグナルに応答したミトコンドリアの動態解析2024
- Author(s)
  今尾遥、小林萌美、沖野良輔、伯野史彦
- Organizer
  骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] Metabolic regulation by amino acid signaling2024
- Author(s)
  Hakuno F
- Organizer
  Core-to-Core international symposium
- Invited
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] アルギニン欠乏に応じて脂肪肝を誘導する腸肝コミュニケーションの探索2024
- Author(s)
  Nishi Hiroki, Nakanishi Sena, Shin-Ichiro Takahashi, and Fumihiko Hakuno
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 低リジン食給餌による骨格筋の筋線維型の変化の解析2024
- Author(s)
  前澤玲緒奈、合田祐貴、沖野良輔、岩井瑠里、西島壮、土田竜貴、西宏起、山中大介、伯野史彦、高橋伸一郎
- Organizer
  骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 特定の血中アミノ酸を誘導できる食事組成を算出するAIモデルの開発；食による生理状態のコントロール手法開発に向けて〜2024
- Author(s)
  山中大介、増田正人、西宏起、合田祐貴、沖野良輔、村上真、宮本崇史、伯野史彦、高橋伸一郎、伊藤公一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] IGFシグナルダイナミクスが筋分化に果たす役割2024
- Author(s)
  小栗舜平、沖野良輔、伯野史彦、高橋伸一郎
- Organizer
  骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 食餌中のリジンの不足は、遅筋の増加を伴って骨格筋への脂質蓄積を誘導する2024
- Author(s)
  合田祐貴、沖野良輔、岩井瑠里、前澤礼緒奈、山中大介、伊藤公一、小野悠介、高橋伸一郎、伯野史彦
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 血中アミノ酸プロファイルが臓器特異的な脂質代謝を制御する2024
- Author(s)
  伯野史彦
- Organizer
  日本農芸化学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] BHBが大腸がん転移に与える影響2024
- Author(s)
  羽藤慧、髙橋彩夏、伯野史彦、髙橋伸一郎
- Organizer
  ジュニア農芸化学会
- Data Source
  KAKENHI-PROJECT-23H00358
[Presentation] The role of FGF21 secreted by amino acid deficiency in the induction of GH resistance2023
- Author(s)
  Maki Saito, Hiroki Nishi, Ichiro Miyata, Fumihiko Hakuno, Shinichiro Takahashi.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] Alternative splicing regulation of insulin receptor (IR) in response to amino acid2023
- Author(s)
  Fumihiko Hakuno, Mariko Isogai, Hiroki Nishi, Sara Fukushima, Eri Matsumoto, Takuhiro Kawakami, Takahito Nakura, Naoyuki Kataoka, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 肝細胞においてアミノ酸欠乏に応答して産生されるFGF21がGH抵抗性誘導に果たす役割の解析2023
- Author(s)
  齋藤真希、西宏起、宮田市郎、伯野史彦、高橋伸一郎
- Organizer
  日本内分泌学会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] Role of Ornithine in Regulation of Liver VLDL Secretion2023
- Author(s)
  Sena Nakanishi, Hiroki Nishi, Daisuke Yamanaka, Yuri Kominami, Hideki Ushio, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] アミノ酸による代謝制御.2023
- Author(s)
  伯野史彦
- Organizer
  第9回骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] Intake of a non-proteogenic amino acid, ornithine abolishes low-arginine diet-induced fatty liver through gut-liver interaction2023
- Author(s)
  Hiroki Nishi, Sena Nakanishi, Daisuke Yamanaka, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] The insulin-independent function of IRS-2 in the secretion of growth factors2023
- Author(s)
  Ayaka Takahashi, Haruka Furuta, Hiroki Nishi, Sheng Yina, Hiroyasu Kamei, Naoyuki Kataoka, Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference
- Data Source
  KAKENHI-PROJECT-23K23793
[Presentation] 肝細胞においてアミノ酸欠乏に応答して産生されるFGF21がGH抵抗性誘導に果たす役割の解析2023
- Author(s)
  齋藤真希、西宏起、宮田市郎、伯野史彦、高橋伸一郎
- Organizer
  日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-23H00358
[Presentation] 古くて新しいアミノ酸コードの研究2021
- Author(s)
  高橋伸一郎、伯野史彦、山中大介、西宏起、合田祐貴、増田正人、片岡直行、潮秀樹、宮本崇史、豊島由香、竹中麻子、島野仁
- Organizer
  第94回日本生化学会シンポジウム　セッションテーマ：1S08m「先端技術を用いた食事・栄養成分を介した免疫-代謝ネットワークの理解と応用」
- Invited
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Introduction2021
- Author(s)
  高橋伸一郎、伯野史彦
- Organizer
  Kick-off symosium of Core-to-Core International Collaboration on "International research core on regulation of insulin-like activities for extension of health life span" supported by JSPS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 血中アミノ酸による未病診断2021
- Author(s)
  増田正人、伯野史彦、高橋伸一郎
- Organizer
  Metabolites Signaling研究会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 食餌中のアミノ酸量に応答した骨格筋への脂質蓄積2021
- Author(s)
  合田祐貴、伯野史彦、高橋伸一郎
- Organizer
  Metabolites Signaling研究会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 物質代謝を制御するアミノ酸コード-次世代栄養学『AI Nutrition』のすすめ2021
- Author(s)
  高橋伸一郎、伯野史彦
- Organizer
  第15回KOPEM-MDC_Keio Pediatrics Endocrinology and Metabolism, multidisciplinary conference
- Invited
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] メタボローム解析でわかるアミノ酸シグナルが肝細胞の脂肪蓄積に果たす役割2021
- Author(s)
  山中大介, 増田正人, 西宏起, 合田祐貴, 伯野史彦, 高橋伸一郎, 伊藤公一
- Organizer
  日本分子細胞生物学会ワークショップ 3AW-13「統合的な栄養学研究で紡ぐ次世代栄養学」
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] オルニチンを介したアミノ酸の新しい代謝制御シグナル機構2021
- Author(s)
  西宏起、伯野史彦、高橋伸一郎
- Organizer
  Metabolites Signaling研究会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Roles of IRS-1-Induced Cell Competition in Myogenic Differentiation.2019
- Author(s)
  Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Function of pyrroline-5-carboxylate reductase 2 (PYCR2) which associates with insulin receptor substrate (IRS) 2 in cell survival in neuroblastoma cells. Poster presentation.2019
- Author(s)
  Eisuke Kaba, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] IRS1遺伝子変異（p.Ser685_Ser686del）は、IGF作用のみに影響を与え、成長障害を引き起こす2019
- Author(s)
  鞁嶋有紀　伯野史彦　妹尾慎太郎　山口由起子　西村玲　花木啓一　高橋伸一郎　神﨑晋
- Organizer
  第53回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10078
[Presentation] Roles of IRS-1-Induced Cell Competition in Myogenic Differentiation.2019
- Author(s)
  Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019
- Author(s)
  Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Function of pyrroline-5-carboxylate reductase 2 (PYCR2) which associates with insulin receptor substrate (IRS) 2 in cell survival in neuroblastoma cells.2019
- Author(s)
  Eisuke Kaba, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 分化過程でのIRS-1の発現量の違いによって生じる細胞競合の意義2019
- Author(s)
  沖野良輔、臼井杏美、増田正人、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.2019
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Numerical simulation of insulin-like growth factor-I (IGF-I) signal2019
- Author(s)
  Fumihiko Hakuno, Masato Masuda, Tatsuya Hayashi, Shin-Ichiro Takahashi
- Organizer
  第57回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] アミノ酸欠乏がミトコンドリアの伸長を誘導する分子メカニズム2019
- Author(s)
  小林萌泉、宮本崇史、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 数理学シミュレーションを用いた生体内でのインスリン様成長因子（IGF）シグナル伝達解析の試み2019
- Author(s)
  伯野史彦、増田正人、渡邉聡、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 肝細胞においてオルニチンを介した新規アミノ酸シグナル経路がmTOR非依存的にG6Pase遺伝子発現を制御する2019
- Author(s)
  福嶋沙良、熊野未佳子、西宏起、山中大介、合田祐貴、豊島由香、竹中麻子、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 血中アミノ酸プロファイルが肝臓への脂肪蓄積量を決定する2019
- Author(s)
  増田正人、西宏起、山中大介、高橋伸一郎、伯野史彦
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Ornithine regulates gluconeogenic gene expression independently from well-established hormonal signaling pathways in hepatocytes2019
- Author(s)
  Sara Fukushima, Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019
- Author(s)
  Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 前立腺がん細胞においてIRS-2の高発現によりMMP-9の産生が亢進しIGF-I依存的な細胞増殖が誘導される2019
- Author(s)
  古田遥佳、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Ornithine regulates gluconeogenic gene expression independently from well-established hormonal signaling pathways in hepatocytes.2019
- Author(s)
  Sara Fukushima, Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.2019
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] タンパク質食給餌によって起こるマウスの成長遅滞はInsulin-like Growth Factor-1（IGF-I）投与により回復する2019
- Author(s)
  内田海登、豊島由香、伯野史彦、高橋伸一郎、竹中麻子
- Organizer
  日本アミノ酸学会第13回学術大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 数理モデルシミュレーションと機械学習の生命科学への応用2019
- Author(s)
  伯野史彦
- Organizer
  第47回東京成長ホルモン成長因子セミナー
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019
- Author(s)
  Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] The mechanism of cell competition induced by differential IRS-1 expression in myoblasts.2019
- Author(s)
  Ryosuke OKINO, Ami USUI, Fumihiko HAKUNO, Shin-Ichiro TAKAHASHI
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Synchronization of IGF signal by cell competition during myogenesis2019
- Author(s)
  Fumihiko Hakuno, Masato Masuda, Ryosuke Okino, Shin-Ichiro Takahashi
- Organizer
  第57回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] The mechanism of cell competition induced by differential IRS-1 expression in myoblasts.2019
- Author(s)
  Ryosuke OKINO, Ami USUI, Fumihiko HAKUNO, Shin-Ichiro TAKAHASHI
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019
- Author(s)
  Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Distinct pathways of GH and TNF-a for suppression of insulin-dependent glucose uptake2018
- Author(s)
  Lisa Nakata, Meri Yonezawa-Sone, Tomomi Ogata, Kouhei Kasahara, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Effects of Amino Acids on Hepatic Gene Expression of Insulin-like Growth Factor-I2018
- Author(s)
  Haruka Nagata, Daisuke Yamanaka, Hiroki Nishi, Yuuki Gouda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Insulin receptor substrate (IRS)1を過剰発現した筋芽細胞で観察される細胞競合の発生メカニズム2018
- Author(s)
  沖野良輔、臼井杏美、伯野史彦、高橋伸一郎
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The difference of IRS-1 protein expression level caused cell competition2018
- Author(s)
  Fumihiko Hakuno, Ami Usui, Hiroyasu Kamei, Ryosuke Okino, Yosuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018
- Author(s)
  山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
- Organizer
  第12回アミノ酸学会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018
- Author(s)
  山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
- Organizer
  第12回アミノ酸学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] The difference of IRS-1 protein expression level caused cell competition2018
- Author(s)
  Fumihiko Hakuno, Ami Usui, Hiroyasu Kamei, Ryosuke Okino, Yosuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Effects of Amino Acids on Hepatic Gene Expression of Insulin-like Growth Factor-I2018
- Author(s)
  Haruka Nagata, Daisuke Yamanaka, Hiroki Nishi, Yuuki Gouda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)1を過剰発現した筋芽細胞で観察される細胞競合の発生メカニズム2018
- Author(s)
  沖野良輔、臼井杏美、伯野史彦、高橋伸一郎
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Distinct pathways of GH and TNF-a for suppression of insulin-dependent glucose uptake2018
- Author(s)
  Lisa Nakata, Meri Yonezawa-Sone, Tomomi Ogata, Kouhei Kasahara, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Serine phosphorylation of GLUT4 positively controls glucose transport activity of GLUT4 causing insulin resistance by growth hormone.2017
- Author(s)
  Hakuno, Fumihiko, Chihiro Watanabe, Lisa Nakata, Mamiko Kubo, Meri Yonezawa- Sone, Kohei Kasahara, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] インスリン受容体RNAの組織特異的な選択的スプライシング機構の解析2017
- Author(s)
  名倉敬仁、尾添敦文、成田佑果、西宏起、千田和広、伯野史彦、片岡直行、高橋伸一郎
- Organizer
  第40回日本分子生物学会年会 2017年度生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Rapid increase in fibroblast growth factor 21 under protein malnutrition and its impact on growth, insulin secretion and lipid metabolism2017
- Author(s)
  Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IGFシグナル異常による成長制御2017
- Author(s)
  伯野史彦、鞁嶋有紀、神崎晋、高橋伸一郎
- Organizer
  内分泌代謝サマーセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 古くて新しいアミノ酸シグナルによるインスリン様活性の調節機構2017
- Author(s)
  高橋伸一郎、伯野史彦、潮秀樹、加藤久典、竹中麻子、豊島由香、増田正人
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 3T3-L1脂肪細胞のインスリン依存的な糖取り込みに果たすAkt基質、AS47とAS105の機能2017
- Author(s)
  中田理沙、曽根（米澤）芽里、緒形友美、笠原浩平、高橋伸一郎、伯野史彦
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] アミノ酸欠乏が肝臓のインスリン成長因子-I遺伝子発現に及ぼす影響の解析2017
- Author(s)
  長田悠加、山中大介、西宏起、合田祐貴、熊野未佳子、豊島由香、竹中麻子、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 筋分化過程における細胞競合によるシグナルの同期化2017
- Author(s)
  伯野史彦
- Organizer
  玉原サマースクール
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017
- Author(s)
  Fumihiko Hakuno
- Organizer
  International Seminar "Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of helthy lifeplan and improvemnt of quality for human and animals"
- Place of Presentation
  東京大学中島記念ホール（東京、文京区）
- Year and Date
  2017-01-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Amino acid-deficiency signal induces insulin-like effects on gluconeogenic gene regulation independently of insulin signaling in hepatocytes.2017
- Author(s)
  Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017
- Author(s)
  Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin system in Physiology & Disease
- Place of Presentation
  Marriot Hotel Ventura (Ventura, CA, USA)
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Roles of Insulin/Insulin-like growth factor signaling in hypoxia/reoxygenation induced catch-up growth in zebrafish embryo2017
- Author(s)
  Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] mTOR によるIRS-1 の分解制御がインスリン様成長因子シグナルの時間的制御に果たす役割2017
- Author(s)
  米山鷹介、稲光智美、伯野史彦、高橋伸一郎
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] アミノ酸欠乏に応答した肝臓の糖新生酵素遺伝子の発現抑制機構の解明2017
- Author(s)
  Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition2017
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Ryuji Shioya, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Dietary amino acids control lipid accumulation in the liver, skeletal muscle or adipose tissue in an amino acid-specific manner2017
- Author(s)
  Daisuke Yamanaka, Hiroki Nishi, Yuki Goda, 1Mikako Kumano, Koichi Ito, Masaya Katsumata, Hisanori Kato, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017
- Author(s)
  Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition.2017
- Author(s)
  Hiroki Nishi. Daisuke Yamanaka. Hiroyasu Kamei. Yuki Goda. Mikako Kumano. Yuka Toyoshima. Asako Takenaka. Kazuhiro Chida. Fumihiko Hakuno. Shin-Ichiro Takahashi
- Organizer
  国際栄養学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Lysine deficiency signal selectively induces lipid accumulation in muscle and adipose tissues of rats2017
- Author(s)
  Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Hiroyasu Kamei, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Kazuhiro Chida, Masugi Nishihara, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF/insulin signaling through a novel mechanism2017
- Author(s)
  Toshiaki Fukushima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Prolonged IGF signaling by IRS-1-mediated control of delayed IGF-IR internalization2017
- Author(s)
  Yosuke Yoneyama, Fumihiko, Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Serine phosphorylation of GLUT4 positively controls glucose transport activity of GLUT4 causing insulin resistance by growth hormone2017
- Author(s)
  Fumihiko Hakuno, Chihiro Watanabe, Lisa Nakata,Mamiko Kubo, Meri-Yonezawa-Sone, Kohei, Kasahara, Shin‐Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Amino acid-deficiency signal induces insulin-like effects on regulation of gluconeogenic gene regulation independently of insulin signaling in hepatocytes2017
- Author(s)
  Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 自己組織化マップを用いた食餌中アミノ酸濃度、血中アミノ酸濃度、肝臓脂肪量の関係分類2017
- Author(s)
  伯野史彦、増田正人、中林靖、西宏起、山中大介、高橋伸一郎、塩谷隆二
- Organizer
  計算力学学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Temporal regulation of insulin-like growth factor signaling by IRS-1-dependent feedback loops2017
- Author(s)
  ousuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Early embryonic insulin receptor substrate-1 signaling underpins neural crest cell survival contributing to catch-up growth induced by changing environmental oxygen tension in developing zebrafish.2017
- Author(s)
  Hiroyasu Kamei, Yosuke Yoneyama, Fumihiko Hakuno, Rie Sawada, Toshiaki Shimizu, Cunming Duan, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Molecular functions and physiological significance of a novel PI 3-kinase-binding protein that potentiates IGF activities2017
- Author(s)
  Daisuke Yamanaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The SCFβ-TRCP E3 ligase complex induces IRS-1 degradation mediated by mTORC1 pathway2017
- Author(s)
  Tomomi Inamitsu, Yosuke Yoneyama, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017
- Author(s)
  Ami Usui, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate 2 (IRS2) に相互作用するタンパク質、Pyrroline-5-carboxylate reductase 2 (PYCR2) が細胞死に及ぼす影響の解析2017
- Author(s)
  蒲瑛介、曽根（米澤）芽里、伯野史彦、高橋伸一郎
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] インスリン受容体RNAの組織特異的な選択的スプライシング機構の解析2017
- Author(s)
  Yuuri Nakaoki, Atufumi Ozoe, Meri Yonezawa-Sone, Toshiaki Fukushima, Kazuhiro Chida, Fumihiko Hakuno, 名倉敬仁、尾添敦文、成田佑果、太田一実、千田和広、伯野史彦、片岡直行、高橋伸一郎
- Organizer
  19回日本RNA学会年会　RNA2017
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Regulation of Insulin-like activities through alternative splicing of Insulin Receptor pre-mRNA2017
- Author(s)
  Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Lysine deficiency signal selectively induces lipid accumulation in muscle and adipose tissues of rats.2017
- Author(s)
  Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Hiroyasu Kamei, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Kazuhiro Chida, Masugi Nishihara, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  国際栄養学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition.2017
- Author(s)
  ○Nishi, Hiroki, Daisuke Yamanaka1, Hiroyasu Kamei, Yuki Goda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Ryuji Shioya, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 古くて新しいアミノ酸シグナルによるインスリン様活性の調節機構2017
- Author(s)
  高橋伸一郎、伯野史彦、潮秀樹、加藤久典、竹中麻子、豊島由香、増田正人
- Organizer
  第40回日本分子生物学会年会 2017年度生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Insulin receptor substrates-associated proteins that are involved in the insulin resistance2017
- Author(s)
  Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Short stature with IGF-I receptor gene anomaly.2017
- Author(s)
  Yuki Kawashima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017
- Author(s)
  Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Development of a new method for evaluating cell mechano-response to multidirectional and anisotropic mechanical strain by using photodegradable hydrogel2016
- Author(s)
  KAWAMURA Ryuzo; KWOKHOI, Ng; TANAKA Taisei; KOJIMAMasaru; ARAI Tatsuo; YONEYAMA, Yosuke; HAKUNO, Fumihiko; TAKAHASHI, Shin-ichiro; TAKAGI, Toshiyuki; KANAMORI, Toshiyuki; NAKABAYASHI Seiichiro; SUGIURA Shinji
- Organizer
  コロイドおよび界面化学討論会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Actin cytoskeleton remodeling dynmics of adherent cells under to the photo-induced mechanical strain of gelatin substrate2016
- Author(s)
  Kwokhoi Ng, Kentaro Iketaki, Ryuzo Kawamura, Seiichiro Nakabayashi, Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi, Fumiki Yanagawa, Toshiyuki Takagi, Shinji Sugiura, Toshiyuki Kanamori, Hiroshi Yoshikawa
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Actin cytoskeleton remodeling dynmics of adherent cells under to the photo-induced mechanical strain of gelatin substrate2016
- Author(s)
  Kwokhoi Ng, Kentaro Iketaki, Ryuzo Kawamura, Seiichiro Nakabayashi, Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi, Fumiki Yanagawa, Toshiyuki Takagi, Shinji Sugiura, Toshiyuki Kawamori, Hiroshi Yoshikawa
- Organizer
  日本生物物理学会
- Place of Presentation
  つくば国際会議場（茨城、つくば）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Insulin receptor substrates (IRSs), interacting with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulate cap-independent translation2016
- Author(s)
  Yuuri Nakaoki, Atufumi Ozoe, Meri Yonezawa-Sone, Toshiaki Fukushima, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  RNA2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The Novel Role of Glucose Transporter 4 Serine Phosphorylation in Insulin Resistance Induced by Growth Hormone2016
- Author(s)
  Chihiro Watanabe, Mamiko Kubo, Meri Yonezawa-Sone, Kohei Kasahara, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルに応答した肝臓への脂質蓄積機構の解明2016
- Author(s)
  西宏起、亀井宏泰、山中大介、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Place of Presentation
  東京大学　（東京、文京区）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 全アミノ酸あるいはリジンを不足させた食餌を給餌した成長期のラットでは脂肪組織が増加する2016
- Author(s)
  合田祐貴、西宏起、山中大介、亀井宏泰、勝俣昌也、加藤久典、豊島由香、竹中麻子、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルに応答した肝臓への脂質蓄積機構の解明2016
- Author(s)
  西宏起、亀井宏泰、山中大介、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel Roles of the Akt Substrate, AS47 in GH-Induced Inhibition of Insulin-Stimulated Glucose Uptake in Adipocytes without Affecting GLUT4 Translocation to Plasma Membranes2016
- Author(s)
  Meri Yonezawa-Sone, Kouhei Kasahara, Lisa Nakata, Chihiro Watanabe, Keitaro Yamanouchi, Masugi Nishihara, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  8th International Congress of GRS-IGF society,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] SCFユビキチンリガーゼ複合体によるリン酸化依存的なインスリン受容体基質の分解制御2016
- Author(s)
  稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川、横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2016
- Author(s)
  Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
- Organizer
  RNA2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA.2016
- Author(s)
  Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
- Organizer
  RNA2016
- Place of Presentation
  国立京都国際会館（京都府、京都）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] インスリン受容体基質がcap非依存的翻訳促進に果たす新規機能2016
- Author(s)
  中沖優里、尾添淳文、曽根芽里、山中大介、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] OR複合体1経路がインスリン受容体基質の分解とインスリン様成長因子（IGF）I受容体のエンドサイトーシスに果たす役割2016
- Author(s)
  米山鷹介、稲光智美、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] SCFユビキチンリガーゼ複合体によるリン酸化依存的なインスリン受容体基質の分解制御2016
- Author(s)
  稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] TOR複合体1経路がインスリン受容体基質の分解とインスリン様成長因子（IGF）I受容体のエンドサイトーシスに果たす役割2016
- Author(s)
  米山鷹介、稲光智美、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Place of Presentation
  東京大学　（東京、文京区）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 全アミノ酸あるいはリジンを不足させた食餌を給餌した成長期のラットでは脂肪組織が増加する2016
- Author(s)
  合田祐貴、西宏起、山中大介、亀井宏泰、勝俣昌也、加藤久典、豊島由香、竹中麻子、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川、横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] インスリン受容体基質がcap非依存的翻訳促進に果たす新規機能2016
- Author(s)
  中沖優里、尾添淳文、曽根芽里、山中大介、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター、札幌市産業振興センター、札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] IRS-1の細胞膜への恒常的発現が骨格筋分化に及ぼす影響の解析2015
- Author(s)
  臼井杏美、伯野史彦、米山鷹介、高橋伸一郎
- Organizer
  第４回細胞競合コロキウム
- Place of Presentation
  北海道大学　遺伝子病制御研究所、北海道
- Year and Date
  2015-03-12
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Effect of branched-chain amino acids on insulin secretion during feeding2015
- Author(s)
  Mami Horiuchi, Tomoya Takeda, Yori Ozaki, Fumihiko Hakuno, Shin-Ichiro Takahashi and Asako Takenaka
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  ワークショップ第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 食餌中の全アミノ酸やリジンの不足は筋肉への脂肪蓄積を誘導する2015
- Author(s)
  合田祐貴、西宏起、山中大介、亀井宏泰、山内啓太郎、勝俣昌也、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] GLUT4のセリンリン酸化が糖膜透過能に果たす役割2015
- Author(s)
  渡部千尋, 久保真実子, 米澤（曽根）芽里, 伯野史彦, 高橋伸一郎
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Fatty liver caused by acute amino acid deficiency2015
- Author(s)
  Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] セリン／スレオニンホスファターゼPP1/PP2Aがインスリン受容体基質のリン酸化と分解の調節に果たす役割2015
- Author(s)
  稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Diacylglycerol kinase zeta and PIP5K1 cooperatively enhanced insulin-induced glucose uptake in 3T3-L1 adipocytes2015
- Author(s)
  Fumihiko Hakuno, Ting-Yu Liu T, M Kakino, Hitoshi Fujimoto, Yasutoshi Ando, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015
- Author(s)
  Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Spain, Madrid
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Early embryonic Irs-1 signaling governs the neural crest cell survival that is indispensable for catch-up growth in zebrafish embryo induced by the changing environmental oxygen tension2015
- Author(s)
  Hiroyasu Kamei H, Yosuke Yoneyama, Rie Sawada R, Cunming Duan, Fumihiko Hakuno, Toshiaki Shimizu T, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The protein or compound that inhibits interaction between DGKζ and IRS-1 restore the TNF-α-induced suppression of glucose uptake in 3T3-L1 adipocytes.2015
- Author(s)
  Yu BC, Liu TY, Ando Y, Ito A, Yoshida M, Hakuno F , Chida K, Takahashi S-I
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Insulin receptor substrates- associated proteins which are related with insulin resistance2015
- Author(s)
  Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Effect of branched-chain amino acids on insulin secretion during feeding.2015
- Author(s)
  Mami Horiuchi, Tomoya Takeda, Yori Ozaki, Fumihiko Hakuno, Shin-Ichiro Takahashi, Asako Takenaka.
- Organizer
  12th Asian Congress of Nutrition.
- Place of Presentation
  Yokohama Japan
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] クラスリンアダプタータンパク質AP-2との相互作用を介したIRS-1によるIGF-I受容体エンドサイトーシスの新規フィードバック制御機構2015
- Author(s)
  米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Lipid accumulation in muscle by chronic amino acid deficiency2015
- Author(s)
  Yuuki Gouda, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  スペイン　マドリッド
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2015
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrates- associated proteins which are related with insulin resistance2015
- Author(s)
  Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Spain, Madrid
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] IRS-1 is a negative feedback regulator of IGF-I receptor internalization via interaction with AP-2 clathrin adaptor complex2015
- Author(s)
  Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] GLUT4のセリンリン酸化が糖膜透過能に果たす役割2015
- Author(s)
  渡部千尋、久保真実子、米澤（曽根）芽里、伯野史彦、高橋伸一郎
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015
- Author(s)
  Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  スペイン　マドリッド
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Metabolic diseases, metabolic syndrome, metabolomics, and aging2015
- Author(s)
  BuChin Yu, TingYu Liu, Yasutoshi Ando, Akihiro Ito, Minoru Yoshida, Fumihiko Hakuno, Kazuhiro Chida and Shin-Ichiro Takahashi
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells2015
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 筋分化過程でIRS-1の発現量の違いが細胞競合を引き起こす2015
- Author(s)
  臼井杏美、米山鷹介、千田和広、高橋伸一郎、伯野史彦
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015
- Author(s)
  Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Fatty liver caused by acute amino acid deficiency2015
- Author(s)
  Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities
- Place of Presentation
  スペイン　マドリッド
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] IRS1を恒常的に発現したL6筋芽細胞は細胞競合を引き起こし、筋分化が抑制される2015
- Author(s)
  伯野史彦、米山鷹介、臼井杏美、高橋伸一郎
- Organizer
  第４回細胞競合コロキウム
- Place of Presentation
  北海道大学　遺伝子病制御研究所、北海道
- Year and Date
  2015-03-12
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 肝臓におけるアミノ酸欠乏に応答したインスリン受容体基質（IRS）-2量の増加とトリグリセリドの蓄積の新規分子機構2015
- Author(s)
  西宏起、亀井宏泰、山中大介、赤西成美、森友美、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会2015年大会
- Place of Presentation
  岡山大学津島キャンパス、岡山
- Year and Date
  2015-03-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 筋分化過程でIRS-1の発現量の違いが細胞競合を引き起こす2015
- Author(s)
  臼井杏美、米山鷹介、千田和広、高橋伸一郎、伯野史彦
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] PI 3-kinase-binding protein PI3KAP plays an important role in cell migration and is required for embryogenesis in zebrafish2015
- Author(s)
  Hiroki Kawauchi, Daisuke Yamanaka, Hiroyasu Kamei, Fumihiko Hakuno, Shiro Minami, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸欠乏をシグナルとした肝臓特異的な脂質蓄積の新機構の解明2015
- Author(s)
  西宏起、山中大介、亀井宏泰、森友美、豊島由香、竹中麻子、潮秀樹、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  ワークショップ・BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会
- Place of Presentation
  神戸国際会議場、神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Phospho-tyrosine independent roles of insulin receptor substrates2014
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  International Seminar “Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing” sponsored by Core-to-Core Project
- Place of Presentation
  東京
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] 低酸素環境で成長が遅滞したゼブラフィッシュ胚が常酸素環境で追いつき成長を起こす機構の解明：インスリン受容体基質（IRS）-1の機能2014
- Author(s)
  亀井宏泰、山口里恵、米山鷹介、伯野史彦、清水俊明、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS1を恒常的発現したL6筋芽細胞は、細胞競合を引き起こし、筋分化が抑制される2014
- Author(s)
  伯野史彦、米山鷹介、臼井杏美、尾添淳文、高橋伸一郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing2014
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Lipopolysaccharide (LPS) treatment increased the protein levels of GKAP42 (42-kDa cGMP-dependent protein kinase anchoring protein) followed by inhibition of glucose transporter (GLUT) 4 translocation to the plasma membrane and glucose uptake in adipocytes2014
- Author(s)
  Bu Chin Yu, Yasutoshi Ando, Yuko Obata, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Constitutive IRS1 expression causes cell competition, leading to defect in myogenic differentiation2014
- Author(s)
  Fumihiko Hakuno, Yosuke Yoneyama, Atsufumi Ozoe and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 甲状腺細胞の増殖に必須なアダプタータンパク質PI3KAPの遺伝子欠損は甲状腺機能を低下させる2014
- Author(s)
  山中大介、伯野史彦、南史朗、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Mechanisms for Regulation of Acetylation of Insulin-Receptor Substrate (IRS)-1, Regulating Insulin-Like Growth Factor (IGF) Signaling2014
- Author(s)
  Kumiko Fujieda, Yosuke Yoneyama, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ICE/ENDO 2014
- Place of Presentation
  McComick Place West, Chicago Illinois, USA
- Year and Date
  2014-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phospho-tyrosine independent roles of insulin receptor substrates2014
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
- Place of Presentation
  Nakashima Hall, The University of Tokyo, Tokyo
- Year and Date
  2014-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] ユビキチンリガーゼNedd4がIRS-2を介したIGFシグナルを増強する新しい分子機構2014
- Author(s)
  福嶋俊明、吉原英人、古田遥佳、伯野史彦、佐伯泰、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン抵抗性発生の新しい機序としてのGLUT4のセリンリン酸化2014
- Author(s)
  高橋伸一郎、久保真実子、渡部千尋、笠原浩平、曽根芽里、千田和広、伯野史彦
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム、東京
- Year and Date
  2014-04-11
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 complexes enhance IGF-I signals, and their roles in IGF-I action in prostate cancer cell proliferation2014
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells2014
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Loss of PI 3-kinase-binding protein PI3KAP/XB130 suppresses thyroid function and induces enlargement of thyroid glands in mice2014
- Author(s)
  Daisuke Yamanaka, Fumihiko Hakuno, Shiro Minami, Koshi Hashimoto, Kouichi Suzuki, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸欠乏培地で培養した肝細胞ではインスリン受容体基質（IRS）-2量が増加し脂肪蓄積が起こる2014
- Author(s)
  森友美、亀井宏泰、赤西成美、尾添淳文、伯野史彦、千田和広、加藤久典、豊島由香、竹中麻子、高橋伸一郎
- Organizer
  日本農芸化学会大会2014年度
- Place of Presentation
  川崎
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] ゼブラフィッシュを用いたSHOX（short stature homeobox containing）遺伝子の胚発生における役割の解析2014
- Author(s)
  山口里恵、亀井宏泰、伯野史彦、高橋伸一郎、清水俊明
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 脂肪細胞のインスリン依存性糖輸送機構における新規Akt基質の生理的意義2014
- Author(s)
  曽根芽里、笠原浩平、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS-1 promotes embryonic growth of zebrafish through IGF-IR signal-dependent and -independent mechanisms in response to developmental stages and environmental oxygen availability2014
- Author(s)
  Hiroyasu Kamei, Rie Sawada, Yosuke Yoneyama, Fumihiko Hakuno, Toshiaki Shimizu, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構2014
- Author(s)
  成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] ゼブラフィッシュの初期発生におけるphosphatidylinositol 3-kinase（PI3K）の新規結合タンパク質の役割2014
- Author(s)
  川内啓希、山中大介、亀井宏泰、南史朗、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 低タンパク質食摂取がインスリン受容体基質(IRS)-2 に及ぼす影響の解析2013
- Author(s)
  丸井未槻、日野美佳、金子梨紗、尾崎依、吉原英人、亀井宏泰、伯野史彦、高橋伸一郎、竹中麻子
- Organizer
  第5回日本アミノ酸学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2013-07-26
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis2013
- Author(s)
  Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2013
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2013-06-15
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling2013
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Shin-Ichiro Takahashi
- Organizer
  EMBO Conference"Ubiquitin and ubiquitin-like proteins : from structure to function
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Constitutive expression suppressed cell invasion, leading to inhibition of myogenesis2013
- Author(s)
  Fumihiko Hakuno.
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease: From Pathophysiology to Targeted Therapy”
- Place of Presentation
  Karolinska Institute, Stockholm
- Invited
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Roles of insulin receptor substrate-1 interacting with clathrin adaptor AP-2 complex at submembranous actin cytoskeleton2013
- Author(s)
  Yosuke Yoeneyama, Kazuhiro Chida, Fumihiko Hakuno , Shin-Ichiro Takahashi.
- Organizer
  American Society of Cell Biology
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] インスリン受容体基質（IRS）-1のアセチル化酵素と脱アセチル化酵素の特定2013
- Author(s)
  藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Identification of proteins proximal to insulin receptor substrate (IRS)-1 in the intracellular vesicle compartment2013
- Author(s)
  Yosuke Yoneyama, Akihiro Ito, Kazuhiro Chida, Minoru Yoshida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and diseases
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Constitutive IRS-1 expression suppressed cell invasion, leading to inhibition of myogenesis in L6 myoblasts2013
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and disease
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] インスリン受容体基質（IRS）-1のアセチル化酵素と脱アセチル化酵素の特定2013
- Author(s)
  藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Constitutive IRS1 expression suppressed cell invasion and migration, leading to inhibition of myogenesis in L6 myoblasts.2013
- Author(s)
  Fumihiko Hakuno, Yosuke Yoneyama, Kazuhiro Chida, Shin-Ichiro Takahashi.
- Organizer
  American Society of Cell Biology
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Phosphoglycerate-mutase 5 (PGAM5) is involved in dephosphorylation of insulin receptor substrates (IRSs) and controlling insulin-like activities2013
- Author(s)
  Junichi Inobe, Toshiaki Fukushima, Akihiro Ito, Yukako Kida, Takashi Shiano, Kazuhiro Chida, Minoru Yoshida, Tomoichiro Asano, Kouske Takeda, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and diseases
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling2013
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
- Organizer
  EMBO Conference “Ubiquitin and ubiquitin-like proteins: from structure to function
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis.2013
- Author(s)
  Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2013
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Ubiquitin ligase Nedd4 interacts with insulin receptor substrate (IRS)-2 in response to humoral/nutritional stimuli, thereby enhancing IRS-2-mediated IGF/insulin signals through a novel mechanism2012
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Hideyuki Sakoda, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent proliferation2012
- Author(s)
  Yosuke Yoneyama, Satoshi Yoshinaga, Masao Matsuo, Kazumi Take, Tomohiro Kabuta, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-18
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Diacylglycerol kinase ζ , a novel binding partner of insulin receptor substrates, negatively modulated GLUT4 translocation in 3T3-L1 adipocytes.2012
- Author(s)
  Hakuno F, Ando Y, Kakino M, Fujimoto H, Chida K, Takahashi SI
- Organizer
  6rh GRS-IGF 2012
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors (IGFs)2011
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Kazuhiro Chida, Tomoichiro Asano, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference"Insulin-like Growth Factors in Physiology & Disease"
- Place of Presentation
  Ventura CA, USA
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] 肝細胞においてNedd4はインスリン受容体基質(IRS)-2のユビキチン化を介してインスリンシグナルを増強する2011
- Author(s)
  福嶋俊明,吉原英人,伯野史彦,佐伯泰,田中啓二,伊藤昭博,中津祐介,鎌田英明,高橋伸一郎,浅野知一郎
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(口頭発表、ポスター発表)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] PI 3-kinase activation through c-Src-dependent tyrosine phosphorylation of PI3KAP, a novel binding partner of a PI 3-kinase p85 regulatory subunit, plays novel roles in priming cells to IGF2010
- Author(s)
  Yamanaka D, Akama T, Fukushima T, Minami S, Chida K, Hakuno F, Takahashi SI.
- Organizer
  The 5th international congress of the GRS and IGF society
- Place of Presentation
  New York(USA)
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-21580345
[Presentation] PI 3-kinase activation through c-Src-dependent tyrosine phosphorylation of PITKAP, anovel bining partner of a PI 3-kinase p85 regulatory subunit, plays novel roles in priming2010
- Author(s)
  山中大介、伯野史彦, ら
- Organizer
  The Fifth International Congress of the GRS and IGF Society
- Place of Presentation
  New York (USA)
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-21580345
[Presentation] Continuous activation of IGF signaling inhibits myogenic differentiation of L6 myoblasts2010
- Author(s)
  Fumihiko Hakuno, et al
- Organizer
  The 5th International Congress of GRS and IGF Society
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] PI 3-kinase activity associated with PI3KAP/XB130 that is recruited to F-actin is required for potentiation of IGF-I-induced cell proliferation2009
- Author(s)
  Yamanaka D, Akama T, Fukushima T, Minami S, Chida K, Hakuno F, Takahashi SI.
- Organizer
  第32回分子生物学会年会
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21580345
[Presentation] PI 3-kinase activity associated with PITKAP/XB 130 that is recruited to F-actin is required for potentiation of IGF-I-induced cell proliferation.2009
- Author(s)
  Yamanaka D, Akama T, Fukushima T, Minami S, Chida K, Hakuno F, Takahashi SI
- Organizer
  第32回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21580345
[Presentation] Overexpression of IRS-1 suppressesinitiation of myogenesis throughexclusion of Foxo1 from the nucleus inthe PI 3-kinase-dependent mechanism.2008
- Author(s)
  Yoko Yamauchi, Gen Kaneko, HiroshiOkajima, T. Kadowaki, KeitaroYamanouchi, Jun Nakae, Fumihiko Hakuno,Shin-Ichiro Takahashi
- Organizer
  4^<th> International Congress of GRS-IGFSociety
- Place of Presentation
  (Genova, Italy) Oral (Yamauchi Y)
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] ミトコンドリアに存在するインスリン受容体基質(IRS)の新しい機能2008
- Author(s)
  岡嶋裕志、松尾仁雄、伯野史彦、高橋伸一郎
- Organizer
  日本分子生物学会年会、日本生化学会大会、合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] The role of interactionof insulin receptor substrate (IRS)with Rabankyrin-5/Ankhzn in vesicletransport2008
- Author(s)
  Toshiaki Matsui, Hiroshi Okajima, Fumihiko Hakuno, Shin-IchiroTakahashi
- Organizer
  日本分子生物学会年会、日本生化学会大会、合同大会
- Place of Presentation
  神戸,松井利晃
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] Insulin receptor substrate(IRS)-1 around endosomes, sorted byadaptor protein (AP)-1, is essentialfor IGF-I-induced DNA synthesis in L6myolasts2008
- Author(s)
  Masao Matsuo, Kazumi Take, TomohiroKabuta, Fumihiko Hakuno, Shin-IchiroTakahashi
- Organizer
  4^<th> International Congressof GRS-IGF Society
- Place of Presentation
  (Genova, Italy) Oral (Hakuno F)
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] Ubiquitination of insulinreceptor sustrate (IRS)-2 enhancesits tyrosine phosphorylation inducedby insulin-like growth factor (IGF)-I2008
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara,Fumihiko Hakuno, Shin-IchiroTakahashi
- Organizer
  日本分子生物学会年会、日本生化学会大会、合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] インスリン受容体基質(IRS)-1の強制発現はL6筋芽細胞のFoxo1核局在および筋分化を阻害する2008
- Author(s)
  金子元、山内瑶子、岡嶋裕志、長谷川高士、山内啓太郎、西原真杉、中江淳、伯野史彦、高橋伸一郎
- Organizer
  第81回日本内分泌学会学術総会
- Place of Presentation
  (青森)口頭発表
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] p125, a novelPI 3-kinase-associated protein(PITKAP) plays an essential role incAMP-dependent potentiation of IGFbioactivities in a thyroid cell line2008
- Author(s)
  Daisuke Yamanaka, Takeshi Akama,Toshiaki Fukushima, Chie Kawasaki,Taku Nedachi, Fumihiko Hakuno,Shin-Ichiro Takahashi
- Organizer
  4^<th> International Congress of GRS-IGFSociety
- Place of Presentation
  (Genova, Italy) Oral (Yamanaka D)
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] Nedd4 interactswith insulin receptor substrate(IRS)-1 and IRS-2 leading toenhancement of IGF signals through thePI 3-kinase pathway in a differentmanner2008
- Author(s)
  Toshiaki Fukushima, Fumihiko Hakuno,Shin-Ichiro Takahashi
- Organizer
  4^<th> International Congress of GRS-IGF Society
- Place of Presentation
  (Genova, Italy) Oral (FukushimaT)
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] AP複合体が細胞内局在を決めているIRS-1はインスリンシグナル伝達に重要な役割を果たしている2007
- Author(s)
  松尾仁雄、武和巳、伯野史彦、高橋伸一郎
- Organizer
  日本生物学会年会、日本生化学会大会、合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] Prolonged activation of PI 3-kinase bound to IGF-I receptor is essential for IGF-I-induced cell proliferation2007
- Author(s)
  Yusaku Nakamura, Toshiaki Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The Endocrine Society's 89h Annual Meeting (ENDO2007)
- Place of Presentation
  Toronto, Canada
- Year and Date
  2007-06-02
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] 3T3-L1脂肪細胞ではIRS-2を介したインスリンシグナルがグルコース輸送体(GLUT)4 の活性化に必要である2007
- Author(s)
  緒形友美、新井清志、鈴木尚子、伯野史彦、高橋伸一郎
- Organizer
  日本生物学会年会、日本生化学会大会、合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] Prolonged activation of PI 3-kinase bound to IGF-I receptor is essential for IGF-I-indduced cell proliferation2007
- Author(s)
  伯野史彦
- Organizer
  The American Endocrine Society's 89h Annual Meeting(ENDO2007)
- Place of Presentation
  トロント、カナダ
- Year and Date
  2007-06-02
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] ジアシルグリセロールキナーゼζ(DGKζ)は、インスリン受容体基質(IRS)と結合しIGF/インスリンシグナルを修飾する2005
- Author(s)
  伯野史彦
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] A Novel Splicing Variant of Diacylglycerol Kinaseζ (sDGK)ζ Modulates IGF-I Signals by Competing with Intact DGKt for Binding to Insulin Receptor Substrates2004
- Author(s)
  Hakuno F, et. al.
- Organizer
  Annual Meeting of American Society of Cell Biology
- Place of Presentation
  Washington DC, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] A Novel Splicing Variant of Diacylglycerol Kinase ζ (sDGKζ), Modulates IGF-I Signals by Competing with Intact DGKζ for Binding to Insulin Receptor Substrates2004
- Author(s)
  Hakuno F
- Organizer
  Annual Meeting of American Society of Cell Biology
- Place of Presentation
  Washington DC, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] IRS結合タンパク質、DGKζを介した新しい糖取り込みの調節機構
- Author(s)
  劉亭妤、柿野衛、冨士本仁、伊藤昭博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構
- Author(s)
  成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Novel mechanisms for the expression of insulin/IGF bioactivities by IRS-1-RNA complex
- Author(s)
  Atsufumi Ozoe, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-16
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Analysis of expression of insulin receptor isoforms
- Author(s)
  Yuka Narita, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体基質結合タンパク質、PINCH2を発現するトランスジェニックマウスにおけるインスリンシグナル・生理活性の解析
- Author(s)
  勝部祐介、岡野真由子、植村健治、高瀬和典、伯野史彦、髙橋伸一郎、太田昭彦、戸村秀明
- Organizer
  第106回日本繁殖生物学会大会
- Place of Presentation
  東京
- Year and Date
  2013-09-12 – 2013-09-14
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] A deubiquitinating enzyme, USP7, is associated with IRS-2 forming a negative feedback loop in IGF signaling
- Author(s)
  Hidehito Yoshihara, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Nedd4-IRS2複合体の形成機構と複合体ががん細胞の過増殖誘導に果たす役割
- Author(s)
  福嶋俊明、吉原英人、古田遥佳、伯野史彦、千田和広、佐伯泰、田中啓二、伊藤昭博、吉田稔、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130 crosslinks actin filaments and regulates cell migration
- Author(s)
  Daisuke Yamanaka, Takeshi Akama, Fumihiko Hakuno, Kazuhiro Chida, Kouichi Suzuki, Shiro Minami, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] インスリン受容体基質はG3BP1と相互作用し、cap非依存的なBcl-2 mRNAの翻訳を正に制御する
- Author(s)
  尾添淳文、曽根芽里、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] ミトコンドリア局在型フォスファターゼPGAM5は、インスリン受容体基質のセリン／スレオニンリン酸化と安定性の調節に機能している
- Author(s)
  米山鷹介、鋳延淳一、木田友佳子、福嶋俊明、関根史織、浅野知一郎、千田和広、武田弘資、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Diacylglycerol kinase ζ (DGKζ) and PIP5K1α cooperatively enhanced insulin-induced glucose uptake in 3T3-L1 adipocytes
- Author(s)
  Hakuno F, Liu TY, Kakino M, Fujimoto H, Ando Y, Chida K, Takahashi SI.
- Organizer
  Gordon Conference
- Place of Presentation
  Ventura in USA
- Year and Date
  2015-03-08 – 2015-03-12
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] GKAP(G-kinase-anchoring protein)を介したインスリン抵抗性の新しい発生機構の解明
- Author(s)
  安藤康年、篠澤裕介、飯島由実、大井優子、綿中優介、矢中規之、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-19580324
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling
- Author(s)
  Hidehito Yoshihara, Toshiaki Fukushima, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Shunichiro Iemura, Tohru Natsume, Tomoichiro Asano, Kazuhiro Chida, Leonard Girnita, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] がん細胞では、脱ユビキチン化酵素USP9XによりIGF-I受容体およびIRS-2の分解が抑制され、IGF依存性増殖が亢進している
- Author(s)
  古田遥佳、吉原英人、福嶋俊明、佐伯泰、田中啓二、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Ubiquitin-conjugation to IRS by ubiquitin ligase Nedd4 drives Insulin/IGF signaling
- Author(s)
  Toshiaki Fukushima, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-16
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS-1 expression suppressed cell invasion, leading to inhibition of myogenesis.
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Constitutive IRS1 expression suppressed cell invasion and migration, leading to inhibition of myogenesis in L6 myoblasts
- Author(s)
  Fumihiko Hakuno, Yosuke Yoneyama, Kazuhiro Chida, Shin-Ichiro Takahashi
- Organizer
  2013 ASCB Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2013-12-14 – 2013-12-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 新規PI 3-kinase結合タンパク質PI3KAP/XB130は、TSHとIGFによる甲状腺細胞の相乗的増殖誘導に必須である
- Author(s)
  山中大介、赤間剛、福嶋俊明、南史朗、伯野史彦、高橋伸一郎
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis
- Author(s)
  Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2013
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Insulin receptor substrates (IRSs) form complex with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulating cap-independent translation of Bcl-2 mRNA.
- Author(s)
  Atufumi Ozoe, Meri Sone, Toshiaki Fukushima, Naoyuki Kataoka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback llop in insulin/IGF signaling
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
- Organizer
  EMBO Conference
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2013-10-01 – 2013-10-05
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体基質―Rabankyrin-5複合体がインスリン様成長因子で誘導されるマクロピノサイトーシスに果たす役割の検討
- Author(s)
  矢野貴之、米山鷹介、松井利晃、岡嶋裕志、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Roles of insulin receptor substrate-1 interacting with clathrin adaptor AP-2 complex at submembranous actin cytoskeleton
- Author(s)
  Yosuke Yoneyama, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  2013 ASCB Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2013-12-14 – 2013-12-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA.
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Functional analysis of ubiquitin specific protease USP9X which interacts with IRSs.
- Author(s)
  Haruka Furuta, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[]

1. TAKAHASHI Shin-Ichiro (00197146)

# of Collaborated Projects: 14 results

# of Collaborated Products: 250 results
2. ITO Akihiro (40391859)

# of Collaborated Projects: 8 results

# of Collaborated Products: 43 results
3. NISHIHARA Masugi (90145673)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
4. KATAOKA Naoyuki (60346062)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
5. YASUSHI Saeki (80462779)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
6. KATAOKA Hiroshi (60202008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FUJII WATARU (40708161)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 太田昭彦 (40194154)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 福嶋俊明 (70543552)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
10. 山中大介 (10553266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
11. KANEKO Gen (30466809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. FURUKUBO-TOKUNAGA Katsuo (00272154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAGATA Shinji (40345179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIOYA Ryuji (70282689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. KAWASHIMA YUKI (20403412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 梅原崇史 (20415095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 鬼木健太郎 (00613407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 猿渡淳二 (30543409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 宮本崇史 (50740346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 豊島由香 (70516070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 米山鷹介 (10748289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 増田正人 (60708543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. 西宏起 (90845653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
24. Chida Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 41 results
25. Asano Tomoichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
26. Takenaka Asako

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
27. OZOE Atsufumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
28. Higashi Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. Girnita Leonard

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. Torres-Aleman Ignacio

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. Duan Cunming

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
32. Weghuber Julian

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. Belfiore Antonino

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. O'Connor Rosemary

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. Forbes Briony

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. SUZUKI Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. KATO Hisanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. KAMEI Hiroyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 鎌田英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
40. YU Bu-chin

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
41. 中林靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hakuno Fumihiko 伯野 史彦

HAKUNO Fumihiko 伯野 史彦

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生体の糖脂質代謝スイッチを誘導するオルニチン情報伝達経路の同定とその制御Principal Investigator

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Tissue specific lipid accumulation in response to amino acid signalPrincipal Investigator

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Analysis of insulin resistance through DGKz and development of anti-diabetic medicinePrincipal Investigator

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Molecular mechanism underlying cAMP-induced amplification of IGF mitogenic activity through PI3-kinase binding protein, PI3KAP/XB130.Principal Investigator

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Clearance of insulin resistance by inhibiting diacylglycerol kinaseζ activityPrincipal Investigator

Hakuno Fumihiko 伯野史彦

HAKUNO Fumihiko 伯野史彦