YOSHIDA Hitoshi 吉田均

Researcher Number	30303548
Affiliation (based on the past Project Information) *help	2009: 国立がんセンター(研究所及び東病院臨床開発センター), 分子腫瘍学部, 室長 2007: 国立がんセンター研究所, 分子腫瘍学部, 室長 2005 – 2006: National Cancer Center Research Institute, Molecular Oncology Division, Section Head, 分子腫瘍学部, 室長 2004: 国立がんセンター(研究所), 分子腫瘍学部, 室長 2003: 国立がんセンター, 研究所・分子腫瘍学部, 室長 … More 2002 – 2003: (財)岐阜県国際バイオ研究所, 研究員 2002: (財)岐阜国際バイオ研究所, 研究員 1999 – 2001: 浜松医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Biological Sciences / Biological pharmacy / Pathological medical chemistry / Hematology / Experimental pathology
Keywords	Principal Investigator 急性白血病 / 細胞分化 / レチノイン酸受容体 / PML / 異常スプライシング / 遺伝子変異 / 造血器悪性腫瘍 / SSCP / RT-PCR / p300 / CBP … More Except Principal Investigator … More histone acetyltransferase / MOZ / AML1 / HIPK2 / stem cells / transcription regulation / hematopoiesis / leukemia / PML / chromosome translocation / Leukemia / 白血病 / cell differeniation / nuclear body / タンパク質リン酸化 / 染色体転座 / PHOSPHATIDYLINOSITOL 3-KINASE / AKT / PHOSPHOLIPASE D / Pyk2 / SURVAIVAL / APOPTOSIS / ホスホリパーゼD / スフィンゴシンキナーゼ / ERK / Akt / ホスファチジルイノシトール3キナーゼ / セラミド / 生存シグナル / ホスホリバーゼD / アポトーシス / SH-PTP1 / granulocytic differentiation / retroviral vector / granulocyte colony-stimulating factor receptor / gene therapy / myelodysplastic syndrome / トロンポボエチン受容体遺伝子 / エリスロポエチン受容体遺伝子 / チロシンリン酸化酵素 / 遺伝子導入 / 分化誘導 / 情報伝達経路 / レトロウイルスベクター / 顆粒球コロニー刺激因子受容体遺伝子 / 遺伝子治療 / 骨髄異形成症候群 / hematopoietic stem cells / hematopietic stem cells / hisotone acetyltransferase / neutrophil / cell differentiation / M-CSFR / PU.1 / 幹細胞 / 転写制御 / タンパク質複合体 / 造血 / C型肝炎 / 大腸腫瘍 / c-myc mRNA / 肝癌 / C型肝炎ウイルス / 発癌 / 遺伝子発現 / RNAヘリカーゼ / RNA構造 / DEADボックス蛋白 / 翻訳開始 / CD34 / 薬剤耐性 / P糖蛋白質 / 抗体療法 / CD33 / ヒト化抗CD33抗体 / ATRA耐性 / 亜砒酸 / 急性前骨髄球性白血病 / タミバロテン / 多剤耐性 / 急性骨髄性白血病 / CMA676 Less

Functional study of leukemia-associated factor AML1
- Principal Investigator
  
  KITABAYASHI Issay
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
AML1 complex as a molecular target for leukemia therapy
- Principal Investigator
  
  KITABAYASHI Issay
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Cancer Center Research Institute
RNAヘリカーゼと癌関連遺伝子の発現に関する機能解析と分子イメージング
- Principal Investigator
  
  AKAO Yukihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Gifu International Institute of Biotechnology
CROSS-TALK OF MEMBRANE LIPID SIGNALING IN CELL DEATH AND SURVIVAL
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY
急性前骨髄球性白血病の薬剤耐性例に対する砒素標識ヒト化抗体の有効性と砒素毒性の軽減
- Principal Investigator
  
  竹下明裕
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
白血病における分子標的療法の至適臨床応用と併用による効果増強に関する研究
- Principal Investigator
  
  OHNISHI Kazunori
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
Retrovirus-mediated gene transfer of hematopoietic stimulating factor receptor cDNA into MDS cells and gene therapy
- Principal Investigator
  
  OHNISHI Kazunori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
CBPでPML、レチノイン酸受容体とクロストークする蛋白群の分化誘導療法への応用Principal Investigator
- Principal Investigator
  
  吉田均
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine

All 2008 2007

All Journal Article Presentation

[Journal Article] Roles of the histone aceryltransferase MOZ in normal and malignant hematooiesis2008
- Author(s)
  T.Katsumoto, N.Yoshida, I.Kitabayashi.
- Journal Title
  
  Cancer Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008
- Author(s)
  Katsumoto T, Yoshida N, and Kitabayashi I
- Journal Title
  
  Cancer Sci 99
  
  Pages: 1523-1527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Chromatin regulation by AML1 complex.2008
- Author(s)
  Yoshida H, Kitabayashi I.
- Journal Title
  
  Int. J. Hematol. 7
  
  Pages: 19-24
- NAID
  10021254940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU. 1 to accelerate granulocytic differentiation.2008
- Author(s)
  Tagata Y., Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Leukemia 22
  
  Pages: 273-280
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU.1 to accelerate granulocytic differentiation.2008
- Author(s)
  Tagata Y., Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Leukemia 22
  
  Pages: 273-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008
- Author(s)
  Katsumoto T, Yoshida N, Kitabayashi I
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 1523-7
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Chromatin regulation by AML1 complex2008
- Author(s)
  Yoshida H, Kitabayashi I.
- Journal Title
  
  Int.J.Hematol 7
  
  Pages: 19-24
- NAID
  10021254940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] PML-RARA inits PML IV enhancement of PU.1-induced C/EBPe induced-expression in myeloid differentiation2007
- Author(s)
  Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
- Journal Title
  
  Mol.Cell.Biol 27
  
  Pages: 5819-5834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] PML-RARA inhibits PML IV enhancement of PU. 1-induced C/EBPe induced-expression in myeloid differentiation.2007
- Author(s)
  Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 5819-5834
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Phosphorylation of PML is essential activation of C/EBPe and PU.1 to accelerate granulocytic differentiation2007
- Author(s)
  Tagata Y., Yoshida H, nguyen LA, kato H, Ichikawa H, Tashiro F, Kitabayashi I.
- Journal Title
  
  Mol.Cell.Biol 22
  
  Pages: 273-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.2007
- Author(s)
  Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.2007
- Author(s)
  Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I.
- Journal Title
  
  Oncogene. 26
  
  Pages: 7231-7239
- Data Source
  KAKENHI-PROJECT-17013091
[Presentation] PU.1-mediated upregulation of CSF1R/cFMS/M-CSFR is critical for MOZ- and MLL-leukemia stem cell potential2008
- Author(s)
  Yukiko Aikawa, Takuo Katsumoto, Naomi Yoshida, Kazutsune Yamagata, Akihiko Yokoyama, Issay Kitabayashi
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17013091

1. OHNISHI Kazunori (80252170)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. TAKESHITA Akihiro (00242769)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SHIMIZU Kimiko (00161414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. AKAO Yukihiro (00222505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KITABAYASHI Issay (20261175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. ROKUDAI Susumu (20392334)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. NOZAWA Yoshinori (10021362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. BANNO Yoshiko (50116852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANAKA Masashi (60155166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHGUCHI Kenji (80359257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大野竜三 (70093002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 臼倉治郎 (30143415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIDA Hitoshi 吉田 均

Research Projects

Research Products

Co-Researchers

Functional study of leukemia-associated factor AML1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AML1 complex as a molecular target for leukemia therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNAヘリカーゼと癌関連遺伝子の発現に関する機能解析と分子イメージング

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CROSS-TALK OF MEMBRANE LIPID SIGNALING IN CELL DEATH AND SURVIVAL

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

急性前骨髄球性白血病の薬剤耐性例に対する砒素標識ヒト化抗体の有効性と砒素毒性の軽減

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

白血病における分子標的療法の至適臨床応用と併用による効果増強に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Retrovirus-mediated gene transfer of hematopoietic stimulating factor receptor cDNA into MDS cells and gene therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CBPでPML、レチノイン酸受容体とクロストークする蛋白群の分化誘導療法への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Roles of the histone aceryltransferase MOZ in normal and malignant hematooiesis2008

Author(s)

Journal Title

Data Source

[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008

Author(s)

Journal Title

Data Source

[Journal Article] Chromatin regulation by AML1 complex.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU. 1 to accelerate granulocytic differentiation.2008

Author(s)

Journal Title

Data Source

[Journal Article] Phosphorylation of PML is essential for activation of C/EBPe and PU.1 to accelerate granulocytic differentiation.2008

Author(s)

Journal Title

Data Source

[Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008

Author(s)

Journal Title

Data Source

[Journal Article] Chromatin regulation by AML1 complex2008

Author(s)

Journal Title

YOSHIDA Hitoshi 吉田均