Shimose Shoji 下瀬省二

… Alternative Names

SHIMOSE Shouji 下瀬省二

SIMOSE Shouji 下瀬省二

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Researcher Number	30304439
Other IDs
External Links
Affiliation (Current)	2025: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師
Affiliation (based on the past Project Information) *help	2016: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師 2015: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 統括診療部長 2014: 広島大学, 大学院医歯薬保健学研究院(医), 准教授 2014: 広島大学, 大学院医歯薬学総合研究科, 准教授 2013: 広島大学, 大学院医歯薬保健学研究院, 准教授 … More 2012 – 2013: 広島大学, 医歯薬保健学研究院(医), 准教授 2011: 広島大学, 医歯(薬)学総合研究科, 准教授 2008 – 2011: Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 2006 – 2007: 広島大学, 病院, 講師 2006: 広島大学, 病院・講師 2004 – 2005: 広島大学, 病院, 助手 1999 – 2001: 広島大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Orthopaedic surgery
Keywords	Principal Investigator PET / 骨肉腫 / Liposome / cancer / リポソーム / 癌 / Ewing's sarcoma / Chondrosarcoma / Osteosarcoma / Bisphosphonate … More / 腫瘍細胞浸潤抑制 / 細胞周期 / アポトーシス / ビスフォスフォネート / 転移 / エクソソーム / microRNA / 磁性体リポソーム / 骨再生 / 細胞増殖因子 / 人工骨 / 多血小板血漿 / 磁性体リボソーム / 胎内手術 / 脊髄損傷 … More Except Principal Investigator 骨肉腫 / 癌 / 遺伝子 / Isolated limb perfusion / oncolytic virus / vesicular stomatitis virus / Sarcoma / リポソーム / ウイルス治療 / osteosarcoma / magnetic cationic liposome / external magnetic field / magnetic stealth liposome / targeting / gene transfection / p53遺伝子 / 遺伝子治療 / 局所ターゲッティング / 外磁場 / ステルス磁性体リポソーム / 局所ターゲティング / 遺伝子導入 / Antinociceptive effect / Bennett model / Pain control / Reflex sympathetic dystrophy (RSD) / Linear polarized near-infrared light / 痛覚過敏 / 透過光量 / 直線偏光型赤外線 / 鎮痛効果 / Bennettモデル / 疼痛制御 / 反射性交感神経性ジストロフィー / 直線偏光型近赤外線 / 近赤外線蛍光蛋白 / 腫瘍溶解性ウイルス / 蛍光イメージング / テロメア / テロメラーゼ阻害剤 / 老化 / biomrker / biomarker / 滑膜 / 軟骨 / microRNA / 変形性関節症 / ビスフォスフォネート / 転移性骨腫瘍 Less

Fluorescent tumor cell detection by tumor-specific virus VSV for precise osteosarcoma resection
- Principal Investigator
  
  KUBO Tadahiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Novel Medical therapy using Telomerase Inhibitor TMPyP4 for Osteosarcoma
- Principal Investigator
  
  FUJIMORI Jun
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Exosome-formed miRNA for the treatment of osteosarcomaPrincipal Investigator
- Principal Investigator
  
  SHIMOSE Shoji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Treatment of osteoarthritis using systematic delivery of telomere-related antiaging factors by bubble liposomes and ultrasound exposure
- Principal Investigator
  
  MATSUO Toshihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Therapeutic strategy for osteoarthritis by evaluation and regulation of microRNA
- Principal Investigator
  
  OCHI Mitsuo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Magnetic targeting therapy with new bisphosphonates for the treatment of bone metastasis
- Principal Investigator
  
  KUBO Tadahiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Target therapy in bone and soft tissue sarcomas using magnetic liposomal telomerase inhibitor under an external magnetic force
- Principal Investigator
  
  MATSUO Toshihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Targeted delivery of magnetic Iiposome encapsulated platelet rich plasma for bone formation in a rat bone-defect modelPrincipal Investigator
- Principal Investigator
  
  SHIMOSE Shouji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Isolated limb perfusion for vesicular stomatitis virus delivery in sarcoma-bearing rats
- Principal Investigator
  
  KUBO Tadahiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Anticancer therapy with liposomes combined with fluorodeoxyglucose (FDG) using as a tumor detection agent in position emission tomography (PET)Principal Investigator
- Principal Investigator
  
  SHIMOSE Shoji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cellsPrincipal Investigator
- Principal Investigator
  
  SHIMOSE Shouji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  HIROSHIMA UNIVERSITY
Application of Magnetic Stealth Liposomes in External Magnetic Field for Gene Therapy -Research for the Clinical Application of New Drug Delivery System-
- Principal Investigator
  
  SUGITA Takashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
損傷脊髄の再生に関する基礎的研究-胎内手術モデルを用いて-Principal Investigator
- Principal Investigator
  
  下瀬省二
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Antinociceptive Effect of Central Nerve System with Linear Polarized Near-infrared Light in a Chronic Pain Model
- Principal Investigator
  
  MUNESHIGE Hiroshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  HIROSHIMA UNIVERSITY

All 2016 2014 2012 2011 2010 2009 2007 Other

All Journal Article Presentation

[Journal Article] Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration2014
- Author(s)
  Shinbo K, Miyaki S, Ishitobi H, Kato Y, Kubo T, Shimose S, Ochi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 445 Issue: 2 Pages: 381-387
- DOI
  10.1016/j.bbrc.2014.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592235, KAKENHI-PROJECT-24689057, KAKENHI-PROJECT-25253089
[Journal Article] Minodronate for the treatment of osteoporosis2010
- Author(s)
  Kubo T, Shimose S, Matsuo T, FujimoriJ, Ochi M.
- Journal Title
  
  Drugs Today(Barc)
  
  Volume: 46(1) Pages: 33-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591916
[Journal Article] Antitumor effects of vesicular stomatitis virus for malignant bone Tumors2007
- Author(s)
  T., Kubo, S., Shimose, T., Matsuo, M., Ochi
- Journal Title
  
  The Journal of theJapanese Orthopaedic Association 81
  
  Pages: 911-911
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591633
[Journal Article] Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines.
- Author(s)
  Fujimori J, Matsuo T, Shimose S, Kubo T, Ishikawa M, Yasunaga Y, Ochi M.
- Journal Title
  
  Journal of Orthopaedic Research. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] Prognostic significance of Positron Emission Tomography in patients with sarcoma2016
- Author(s)
  久保忠彦、古田太輔、越智光夫、下瀬省二、藤森淳
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26462267
[Presentation] Cancer immunotherapy with novel bisphosphonates for bone metastasis2012
- Author(s)
  Tadahiko Kubo, Shoji Shimose, Toshihiro Matsuo, Jun Fujimori, and Mitsuo Ochi
- Organizer
  2012 annual meeting of american academy of orthopaedic surgeons
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-21591916
[Presentation] 転移性骨腫瘍に対する新規ビスフォスフォネートの開発2011
- Author(s)
  久保忠彦、下瀬省二、藤森淳、越智光夫
- Organizer
  第44回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  京都府
- Data Source
  KAKENHI-PROJECT-21591916
[Presentation] Inhibition of cell growth by G-quadruplex-interactive agent in osteosarcoma cells.2011
- Author(s)
  Fujimori J, Matsuo T, Shimose S, Kubo T, Ochi M
- Organizer
  Orthopaedic Research Society 2011 Annual Meeting
- Place of Presentation
  Long Beach, USA.
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] Inhibition of Cell Growth by G-quadruplex-interactive Agent in Osteosarcoma Cells2011
- Author(s)
  藤森淳, 松尾俊宏, 下瀬省二, 久保忠彦, 越智光夫
- Organizer
  Orthopaedic Research Society 2011 Annual Meeting
- Place of Presentation
  米国Long beach
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] 骨・軟部腫瘍のテロメア・テロメラーゼ2010
- Author(s)
  松尾俊宏, 下瀬省二, 久保忠彦, 藤森淳, 越智光夫
- Organizer
  第49回鹿児島整形外科懇話会
- Place of Presentation
  鹿児島市
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines.2010
- Author(s)
  Fujimori J, Matsuo T, Shimose S, Kubo T, Yasunaga Y, Ochi M
- Organizer
  Orthopaedic Research Society 2010 Annual Meeting
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] テロメラーゼ阻害剤による骨肉腫細胞への抗腫瘍効果2009
- Author(s)
  藤森淳, 下瀬省二, 久保忠彦, 松尾俊宏, 安永裕司, 越智光夫
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] Antitumor effects of vesicular stomatitis virus for malignant bone Tumors2007
- Author(s)
  T., Kubo, S., Shimose, T., Matsuo, M., Ochi
- Organizer
  The Journal of the Japanese Orthopaedic Association
- Place of Presentation
  Hamamatsu
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591633

1. OCHI Mitsuo (70177244)

# of Collaborated Projects: 10 results

# of Collaborated Products: 13 results
2. KUBO Tadahiko (70397959)

# of Collaborated Projects: 9 results

# of Collaborated Products: 13 results
3. MATSUO Toshihiro (90397977)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
4. MOCHIDUKI Yu (10284192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKASA Tomoyuki (60467769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FUJIMORI Jun (70632256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SAKAGUCHI Takemasa (70196070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YASUNAGA Yuji (40253075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. DEIE Masataka

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HIYAMA Eiso (00218744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAMEI Naosuke (70444685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAKI Shigeru (10392490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. MUNESHIGE Hiroshi (40211601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUGITA Takashi (40235883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SAKAI Akira (70284221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 生田義和 (60034005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 戸田克広

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimose Shoji 下瀬 省二

SHIMOSE Shouji 下瀬 省二

SIMOSE Shouji 下瀬 省二

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Exosome-formed miRNA for the treatment of osteosarcomaPrincipal Investigator

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Targeted delivery of magnetic Iiposome encapsulated platelet rich plasma for bone formation in a rat bone-defect modelPrincipal Investigator

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Anticancer therapy with liposomes combined with fluorodeoxyglucose (FDG) using as a tumor detection agent in position emission tomography (PET)Principal Investigator

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Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cellsPrincipal Investigator

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損傷脊髄の再生に関する基礎的研究-胎内手術モデルを用いて-Principal Investigator

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Shimose Shoji 下瀬省二

SHIMOSE Shouji 下瀬省二

SIMOSE Shouji 下瀬省二