TAKAHASHI Shunji 高橋俊二

… Alternative Names

TAKAHASHL Shunji 高橋俊二

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Researcher Number	30311608
Other IDs
External Links
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー
Affiliation (based on the past Project Information) *help	2015 – 2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー 2013 – 2014: 独立行政法人理化学研究所, 環境資源科学研究センター, ユニットリーダー 2011 – 2012: 独立行政法人理化学研究所, 化学情報・化合物創製チーム, チームヘッド 2009 – 2010: The Institute of Physical and Chemical Research, 化学情報・化合物創製チーム, 専任研究員 2007: The Institute of Physical and Chemical Research, Antibiotics Laboratory, Senior Research Scientist … More 2006: 独立行政法人理化学研究所, 長田抗生物質研究室, 協力研究員 2001: Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 2000: 千葉大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Applied microbiology / Science and Engineering / Transformative Research Areas, Section (II) Except Principal Investigator Bioorganic chemistry / 環境影響評価(含放射線生物学) / General surgery
Keywords	Principal Investigator 放線菌 / 生合成 / 天然化合物 / 二次代謝産物 / ポリケチド / 生合成プラットフォーム / テルペノイド / リベロマイシン / P450 / 遺伝子資源 … More / 微生物二次代謝産物 / 異種発現 / 転写制御因子 / スピロアセタール / リベロマイシンA / デノボデザイン / 複合酵素反応 / 基質チャネリング / メタボロン / 分子間相互作用 / AI / 化学資源 / 微生物潜在機能 / βーカルボリン / 生産誘導 / ケミカルシグナル / プロモーター改変 / 合成生物 / 生合成プラットホーム / 代謝エンジニアリング / 合成生物学 / 二次代謝 / 一次代謝 / 代謝設計 / BACベクター / 微生物 / ドメイン改変 / 機能ドメイン改変 / ポリケチド合成酵素 / Polyketide / Reveromycin A / メタボローム / ゲノムスケールモデル / 生産プラットフォーム / 経路特異的転写因子 / 小分子化合物 / LALファミリー / バイオメディエーター / 休眠遺伝子覚醒 / 結晶化 / 3級水酸基エステル化 / CoA リガーゼ / CoAリガーゼ / アルキルマロニルCoA / スピロアセタール化合物 … More Except Principal Investigator HUMAN CELLS / GENE MUTATION / ヒト細胞 / 二次代謝産物 / ケミカルバイオロジー / 生物活性物質 / X-RAY / ULTRAVIOLET / INTERFERON / PROTEASE / HUMAN CERUM / ストレス / X線 / 紫外線 / インターフェロン / プロテアーゼ / ヒト血清 / 遺伝子変異 / MOLECUALR CHAPERONE / GENE EXPRESSION / RAS CODON 12 / K- / PANCREATIC CANCER / K-ras codon 12 / シャペロン分子 / 遺伝子発現 / 突然変異 / K-ras codon・12 / 膵癌 / 標的分子 / 結晶構造解析 / 低分子化合物 / ライブラリー / 化合物アレイ / リガンド / 受容体 / 相互作用 / 蛋白質 / バイオプローブ / 構造生物学 / 化学生物学 Less

Complex multi-enzyme reactions and unexplored substrate channeling mechanisms in secondary metabolite biosynthesisPrincipal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the molecular basis of biosynthesis that confers bioactivity to natural compounds and de novo design of novel enzymesPrincipal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
銅受容機構の恒常性の攪乱による二次代謝生合成遺伝子の活性化機構の解明Principal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
AI-based functional elucidation of unknown secondary metabolic biosynthetic enzymes and precise analysis of molecular interactionsPrincipal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Institute of Physical and Chemical Research
Establishment of platform for creation of novel bioactive natural products by expression of latent functions of microorganismsPrincipal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
Enhanced production of natural compounds using the potential chemical signal response mechanisms of micro-organismsPrincipal Investigator
- Principal Investigator
  
  Takahashi Shunji
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural productsPrincipal Investigator
- Principal Investigator
  
  Takahashi Shunji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
Construction of biosynthetic platform based on metabolism logic of actinomycete and elucidation of the function of unknown biosynthetic genePrincipal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Institute of Physical and Chemical Research
Construction of terpenoid producing platform in Actinomycetes and creation of novel secondary metabolitesPrincipal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Institute of Physical and Chemical Research
Modification of polyketide synthase and elucidation of enzyme reaction which is difficult in chemical synthesis, and creation of novel natural productsPrincipal Investigator
- Principal Investigator
  
  Takahashi Shunji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Institute of Physical and Chemical Research
Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genes
- Principal Investigator
  
  Osada Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Institute of Physical and Chemical Research
経路特異的転写因子を活用したテルペノイド生合成遺伝子群の一括発現と有用物質生産Principal Investigator
- Principal Investigator
  
  高橋俊二
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
Construction of a biosynthetic logic toward a new era of natural productPrincipal Investigator
- Principal Investigator
  
  Takahashi Shunji
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Institute of Physical and Chemical Research
Novel strategy to awake gene cluster using small molecules that activate LAL family transcriptional regulatorPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shunji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied microbiology
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of reaction mechanism of novel biosynthetic enzymes for derivatization of reveromycinPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shunji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  The Institute of Physical and Chemical Research
Genetic engineering of reveromycin A biosynthetic gene cluster and creation of its derivativesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shunji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  The Institute of Physical and Chemical Research
Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  The Institute of Physical and Chemical Research
Molecular mechanisms of mutation enhancement by serum factors from pancreatic cancer patients and purification of the factors.
- Principal Investigator
  
  KITA Kazuko, 山森秀夫
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  CHIBA UNIVERSITY
Molecular physiological mechanisms which modulate radiation-induced mutagenicity in human.
- Principal Investigator
  
  SUZUKI Nobuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  CHIBA UNIVERSITY

[Book] リベロマイシンＡ生合成にかかわる未知酵素の解明　スピロアセタール環化酵素の発見2013
- Author(s)
  高橋俊二
- Total Pages
  3
- Publisher
  農芸化学会誌
- Data Source
  KAKENHI-PROJECT-24658088
[Book] 生物工学会誌2012
- Author(s)
  高橋俊二
- Total Pages
  95
- Data Source
  KAKENHI-PROJECT-21580104
[Book] 微生物の英知を生かす2012
- Author(s)
  高橋俊二
- Total Pages
  1
- Publisher
  生物工学会誌
- Data Source
  KAKENHI-PROJECT-24658088
[Book] 微生物の英知を生かす2012
- Author(s)
  高橋俊二
- Total Pages
  1
- Publisher
  生物工学会誌
- Data Source
  KAKENHI-PROJECT-24380052
[Book] バイオサイエンスとインダストリー2011
- Author(s)
  高橋俊二、長田裕之
- Data Source
  KAKENHI-PROJECT-21580104
[Book] 科学工業2011
- Author(s)
  長田裕之、高橋俊二
- Data Source
  KAKENHI-PROJECT-21580104
[Book] Comprehensive Natural Products II Chemistry and Biology2010
- Author(s)
  Kuzuyama T., Hemmi H. and Takahashi S. L., Lui, H.-W
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK232024
- Author(s)
 Sakai Katsuyuki、Futamura Yushi、Nogawa Toshihiko、Zhao Yuzhu、Koshino Hiroyuki、Osada Hiroyuki、Takahashi Shunji
- Journal Title
 
 Journal of Natural Products
 
 Volume: 87 Issue: 4 Pages: 855-860
- DOI
 10.1021/acs.jnatprod.3c01076
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22KK0080, KAKENHI-PUBLICLY-23H04564
[Journal Article] Alanyl-tRNA Synthetase-like Enzyme-Catalyzed Aminoacylation in Nucleoside Sulfamate Ascamycin Biosynthesis2024
- Author(s)
  Zheng Yu、Morita Naoko、Takagi Hiroshi、Shiozaki-Sato Yumi、Ishikawa Jun、Shin-ya Kazuo、Takahashi Shunji
- Journal Title
  
  ACS Catalysis
  
  Volume: 14 Issue: 5 Pages: 3533-3542
- DOI
  10.1021/acscatal.3c05667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0080, KAKENHI-PUBLICLY-23H04564
[Journal Article] In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont2024
- Author(s)
 Hashimoto Takuya、Suenaga Hikaru、Amagai Keita、Hashimoto Junko、Kozone Ikuko、Takahashi Shunji、Shin‐ya Kazuo
- Journal Title
 
 Angewandte Chemie International Edition
 
 Volume: 63 Issue: 10
- DOI
 10.1002/anie.202317805
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22KK0080, KAKENHI-PUBLICLY-23H04564
[Journal Article] cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo2023
- Author(s)
  Kato Naoki、Ebihara Kana、Nogawa Toshihiko、Futamura Yushi、Inaba Kazue、Okano Akiko、Aono Harumi、Fujikawa Yuuta、Inoue Hideshi、Matsuda Kazuhiko、Osada Hiroyuki、Niwa Ryusuke、Takahashi Shunji
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 8 Pages: e0290851-e0290851
- DOI
  10.1371/journal.pone.0290851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-21K05319, KAKENHI-PUBLICLY-23H04564, KAKENHI-PROJECT-23K26843
[Journal Article] Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F0582023
- Author(s)
  Nogawa Toshihiko、Kato Naoki、Shimizu Takeshi、Okano Akiko、Futamura Yushi、Takahashi Shunji、Koshino Hiroyuki、Osada Hiroyuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 76 Issue: 6 Pages: 346-350
- DOI
  10.1038/s41429-023-00613-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-20K05872, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-21K05319, KAKENHI-PUBLICLY-23H04564, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-23K26843
[Journal Article] RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity2022
- Author(s)
  Jang Jun-Pil、Jang Mina、Nogawa Toshihiko、Takahashi Shunji、Osada Hiroyuki、Ahn Jong Seog、Ko Sung-Kyun、Jang Jae-Hyuk
- Journal Title
  
  Journal of Microbiology and Biotechnology
  
  Volume: 32 Issue: 3 Pages: 302-306
- DOI
  10.4014/jmb.2110.10039
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities2022
- Author(s)
  Abdelhakim IA, Motoyama Takayuki, Nogawa Toshihiko, Mahmud FB, Futamura Yushi, Takahashi Shunji, Osada Hiroyuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: ahead of print Issue: 7 Pages: 361-374
- DOI
  10.1038/s41429-022-00529-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-20H00416, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-21K19099
[Journal Article] Identification and Characterization of Bifunctional Drimenol Synthases of Marine Bacterial Origin2022
- Author(s)
  Vo Nhu Ngoc Quynh、Nomura Yuhta、Kinugasa Kiyomi、Takagi Hiroshi、Takahashi Shunji
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 17 Issue: 5 Pages: 1226-1238
- DOI
  10.1021/acschembio.2c00163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-20H00416, KAKENHI-PROJECT-21K19099
[Journal Article] Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity2022
- Author(s)
  Hironori Suemune, Doukan Nishimura, Kenjiro Mizutani, Yusuke Sato, Tomoya Hino, Hiroshi Takagi, Yumi Shiozaki-Sato, Shunji Takahashi*, Shingo Nagano*
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 593 Pages: 144-150
- DOI
  10.1016/j.bbrc.2022.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05780, KAKENHI-PUBLICLY-20H05445, KAKENHI-PUBLICLY-21H00283, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-20H00416, KAKENHI-PROJECT-21K19099
[Journal Article] Studies on Streptomyces sp. SN-593: reveromycin biosynthesis, β-carboline biomediator activating LuxR family regulator, and construction of terpenoid biosynthetic platform2022
- Author(s)
  Takahashi Shunji
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 75 Issue: 8 Pages: 432-444
- DOI
  10.1038/s41429-022-00539-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-21K19099
[Journal Article] Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities.2022
- Author(s)
  Adel I., Motoyama T., Nogawa T., Mahmud F.B., Futamura Y., Takahashi S., and Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19099
[Journal Article] 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone2021
- Author(s)
  Sakai Katsuyuki、Takao Risa、Koshino Hiroyuki、Futamura Yushi、Osada Hiroyuki、Takahashi Shunji
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 74 Issue: 9 Pages: 593-595
- DOI
  10.1038/s41429-021-00442-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] The Conserved Colletotrichum spp. Effector Candidate CEC3 Induces Nuclear Expansion and Cell Death in Plants2021
- Author(s)
  Tsushima Ayako、Narusaka Mari、Gan Pamela、Kumakura Naoyoshi、Hiroyama Ryoko、Kato Naoki、Takahashi Shunji、Takano Yoshitaka、Narusaka Yoshihiro、Shirasu Ken
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12
- DOI
  10.3389/fmicb.2021.682155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15500, KAKENHI-PROJECT-17H06172, KAKENHI-PROJECT-19K05961, KAKENHI-PROJECT-20K05967, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-19KK0397
[Journal Article] Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons2021
- Author(s)
  Fujiyama Keisuke、Kato Naoki、Re Suyong、Kinugasa Kiyomi、Watanabe Kohei、Takita Ryo、Nogawa Toshihiko、Hino Tomoya、Osada Hiroyuki、Sugita Yuji、Takahashi Shunji、Nagano Shingo
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 41 Pages: 22401-22410
- DOI
  10.1002/anie.202106186
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06992, KAKENHI-PROJECT-19K12229, KAKENHI-PROJECT-20K15273, KAKENHI-PLANNED-19H05780, KAKENHI-PUBLICLY-20H05445, KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-20K05872, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-19H05645, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] 放線菌二次代謝物の生産を増強する小分子バイオメディエーター2021
- Author(s)
  高橋俊二、シュレス　パンテー、長田　裕之
- Journal Title
  
  化学と生物
  
  Volume: 59 Pages: 176-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19099
[Journal Article] Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-942021
- Author(s)
  A. Abdelhakim Islam、Bin Mahmud Fauze、Motoyama Takayuki、Futamura Yushi、Takahashi Shunji、Osada Hiroyuki
- Journal Title
  
  Journal of Natural Products
  
  Volume: 85 Issue: 1 Pages: 63-69
- DOI
  10.1021/acs.jnatprod.1c00677
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator.2021
- Author(s)
  Takao R, Sakai K, Koshino H, Osada H, Takahashi S.
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 85 Issue: 3 Pages: 714-721
- DOI
  10.1093/bbb/zbaa082
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-20H00416
[Journal Article] Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity2021
- Author(s)
  Jang Jun-Pil、Kwon Min Cheol、Nogawa Toshihiko、Takahashi Shunji、Osada Hiroyuki、Ahn Jong Seog、Ko Sung-Kyun、Jang Jae-Hyuk
- Journal Title
  
  Journal of Microbiology and Biotechnology
  
  Volume: 31 Issue: 12 Pages: 1667-1671
- DOI
  10.4014/jmb.2108.08015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues2020
- Author(s)
  Nogawa Toshihiko、Terai Atsutaka、Amagai Keita、Hashimoto Junko、Futamura Yushi、Okano Akiko、Fujie Manabu、Satoh Noriyuki、Ikeda Haruo、Shin-ya Kazuo、Osada Hiroyuki、Takahashi Shunji
- Journal Title
  
  Journal of Natural Products
  
  Volume: 83 Issue: 12 Pages: 3598-3605
- DOI
  10.1021/acs.jnatprod.0c00755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-20H00416
[Journal Article] Developing Aspergillus niger as a cell factory for food enzyme production2020
- Author(s)
  Li Cen、Zhou Jingwen、Du Guocheng、Chen Jian、Takahashi Shunji、Liu Song
- Journal Title
  
  Biotechnology Advances
  
  Volume: 44 Pages: 107630-107630
- DOI
  10.1016/j.biotechadv.2020.107630
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-20H00416
[Journal Article] β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.2020
- Author(s)
  Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 10230-10230
- DOI
  10.1038/s41598-020-66974-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-20H00416
[Journal Article] β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593.2019
- Author(s)
  Panthee S., Takahashi S.*, Hayashi T., Shimizu T, and Osada H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Issue: 1 Pages: 5802-5802
- DOI
  10.1038/s41598-019-42268-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05455, KAKENHI-PROJECT-16H04905, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945
[Journal Article] An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s2019
- Author(s)
  Kanoh Naoki, Kawamata-Asano Ayano, Suzuki Kana, Takahashi Yusuke, Miyazawa Takeshi, Nakamura Takemichi, Moriya Takashi, Hirano Hiroyuki, Osada Hiroyuki, Iwabuchi Yoshiharu, Takahashi Shunji
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 18023-18023
- DOI
  10.1038/s41598-019-54473-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08262, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666
[Journal Article] Aromatic butenolides produced by a soil ascomycete Auxarthron sp. KCB15F070 derived from a volcanic island2019
- Author(s)
  Kim Jong Won、Son Sangkeun、Kim Gil Soo、Otaka Junnosuke、Miura Yuzuki、Muranaka Atsuya、Uchiyama Masanobu、Lee Jung-Sook、Jang Mina、Ko Sung-Kyun、Takahashi Shunji、Osada Hiroyuki、Jang Jae-Hyuk、Ahn Jong Seog
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 60 Issue: 45 Pages: 151227-151227
- DOI
  10.1016/j.tetlet.2019.151227
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04643, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-17H06173
[Journal Article] Aturanosides A and B, glycosylated anthraquinones with antiangiogenic activity from a soil-derived Streptomyces species.2018
- Author(s)
  Jang J.-P., Hwang G.J., Jang M., Takahashi S., Ko S.K., Osada H., Jang J.H., and Ahn J.S.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 81 Issue: 9 Pages: 2004-2009
- DOI
  10.1021/acs.jnatprod.8b00307
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05455, KAKENHI-PROJECT-16H04905
[Journal Article] Pentaminomycins A and B, hydroxyarginine-containing cyclic pentapeptides from Streptomyces sp. RK88-1441.2018
- Author(s)
  Jang J.-P., Hwang G.J., Kwon M.C., Ryoo I.-J., Jang M., Takahashi S., Ko S.K., Osada H., Jang J.H., and Ahn J.S.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 81 Issue: 4 Pages: 806-810
- DOI
  10.1021/acs.jnatprod.7b00882
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04905
[Journal Article] Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb2018
- Author(s)
  Hashimoto Takuya、Hashimoto Junko、Kozone Ikuko、Amagai Keita、Kawahara Teppei、Takahashi Shunji、Ikeda Haruo、Shin-ya Kazuo
- Journal Title
  
  Organic Letters
  
  Volume: 20 Issue: 24 Pages: 7996-7999
- DOI
  10.1021/acs.orglett.8b03570
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14349, KAKENHI-PLANNED-16H06447, KAKENHI-PUBLICLY-17H05455, KAKENHI-PROJECT-16H04905
[Journal Article] Biosynthesis and structure activity relationship studies of okaramines that target insect glutamate-gated chloride channels2018
- Author(s)
  Kato Naoki、Furutani Shogo、Otaka Junnosuke、Noguchi Akira、Kinugasa Kiyomi、Kai Kenji、Hayashi Hideo、Ihara Makoto、Takahashi Shunji、Matsuda Kazuhiko、Osada Hiroyuki
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 13 Issue: 3 Pages: 561-566
- DOI
  10.1021/acschembio.7b00878
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05454, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-17H01472, KAKENHI-PROJECT-16H04905
[Journal Article] Catenulisporolides, glycosylated triene macrolides from the chemically underexploited actinomycete Catenulispora species.2018
- Author(s)
  Son S., Hong Y.S., Futamura Y., Jang M., Lee J.K., Heo K.T., Ko S.K., Lee J.S., Takahashi S., Osada H., Jang J.H., Ahn J.S.
- Journal Title
  
  Org. Lett.
  
  Volume: 20 Issue: 22 Pages: 7234-7238
- DOI
  10.1021/acs.orglett.8b03160
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04905
[Journal Article] Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-442018
- Author(s)
  Takagi H, Nogawa T, Futamura Y, Takahashi S, Osada H
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 71 Issue: 4 Pages: 480-482
- DOI
  10.1038/s41429-017-0020-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07784, KAKENHI-PROJECT-16H04905
[Journal Article] Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F0582018
- Author(s)
  Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahahi S, Osada H
- Journal Title
  
  The Journal of Antibiotica
  
  Volume: 71 Issue: 1 Pages: 123-128
- DOI
  10.1038/ja.2017.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07784, KAKENHI-PUBLICLY-17H05454, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905
[Journal Article] Control of the stereochemical course of [4+2] cycloaddition during trans-decalin formation by Fsa2-family enzymes2018
- Author(s)
  Kato N, Nogawa T, Takita R, Kinugasa K, Kanai M, Uchiyama M, Osada H, Takahashi S
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 57 Issue: 31 Pages: 9754-9758
- DOI
  10.1002/anie.201805050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07784, KAKENHI-PUBLICLY-17H05430, KAKENHI-PUBLICLY-17H05454, KAKENHI-PUBLICLY-17H05455, KAKENHI-PROJECT-17H01472, KAKENHI-PROJECT-16H04905
[Journal Article] Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44.2018
- Author(s)
  Takagi H., Nogawa T., Futamura Y., Takahashi S., Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 71 Pages: 480-482
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Journal Article] Novel squalene-producing thraustochytrids found in mangrove water.2017
- Author(s)
  Otagiri M., Khalid A., Moriya S., Osada H., Takahashi S.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume: 81 Issue: 10 Pages: 2034-2037
- DOI
  10.1080/09168451.2017.1359485
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Journal Article] RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441.2017
- Author(s)
  Jang JP, Takahashi S, Futamura Y, Nogawa T, Jang JH, Ahn JS, Osada H
- Journal Title
  
  J Antibiot
  
  Volume: 70 Issue: 1 Pages: 102-104
- DOI
  10.1038/ja.2016.65
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784
[Journal Article] Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides2017
- Author(s)
  Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 56 Issue: 7 Pages: 1740-1745
- DOI
  10.1002/anie.201611371
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-24688011, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-25660085, KAKENHI-PROJECT-16K13084, KAKENHI-PROJECT-16H04905, KAKENHI-PROJECT-17F17114
[Journal Article] Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-5932017
- Author(s)
  Khalid A、Takagi H、Panthee S、Muroi M、Chappell J、Osada H、Takahashi S
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 6 Issue: 12 Pages: 2339-2349
- DOI
  10.1021/acssynbio.7b00249
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783, KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905, KAKENHI-PROJECT-16H06276
[Journal Article] Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.2017
- Author(s)
  4.Amagai, K., Ikeda, H., Hashimoto, J., Kozone, I., Izumikawa, M., Kudo, F., Eguchi, T., Nakamura, T., Osada, H., Takahashi, S., Shin-ya
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 3382-3382
- DOI
  10.1038/s41598-017-03308-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-16H06451, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905
[Journal Article] Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.2017
- Author(s)
  Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H
- Journal Title
  
  J Antibiot
  
  Volume: 70 Issue: 2 Pages: 222-225
- DOI
  10.1038/ja.2016.113
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum.2017
- Author(s)
  Jang JP, Nogawa T, Futamura Y, Shimizu T, Hashizume D, Takahashi S, Jang JH, Ahn JS, Osada H
- Journal Title
  
  J Nat Prod
  
  Volume: 80 Issue: 1 Pages: 134-140
- DOI
  10.1021/acs.jnatprod.6b00758
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784, KAKENHI-PROJECT-16H04905
[Journal Article] A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.2016
- Author(s)
  Ray L., Valentic T., Miyazawa T., Withall D.M., Song L., Milligan J.C., Osada H., Takahashi S., Tsai S.-C., and Challis G.L.
- Journal Title
  
  Nat. Commun
  
  Volume: 7 Issue: 1 Pages: 13609-13609
- DOI
  10.1038/ncomms13609
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04905
[Journal Article] Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.2016
- Author(s)
  Shinohara Y, Takahashi S, Osada H, Koyama Y
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 32865-32865
- DOI
  10.1038/srep32865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905
[Journal Article] Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field2016
- Author(s)
  Son S, Ko SK, Kim JW, Lee JK, Jang M, Ryoo IJ, Hwang GJ, Kwon MC, Shin KS, Futamura Y, Hong YS, Oh H, Kim BY, Ueki M, Takahashi S, Osada H, Jang JH, Ahn JS.
- Journal Title
  
  Phytochemistry
  
  Volume: 122 Pages: 154-164
- DOI
  10.1016/j.phytochem.2015.12.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator.2016
- Author(s)
  Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 38385-38385
- DOI
  10.1038/srep38385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276
[Journal Article] Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013.2016
- Author(s)
  Kim JW, Ko SK, Kim HM, Kim GH, Son S, Kim GS, Hwang GJ, Jeon ES, Shin KS, Ryoo IJ, Hong YS, Oh H, Lee KH, Soung NK, Hashizume D, Nogawa T, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
- Journal Title
  
  J Nat Prod
  
  Volume: 79 Issue: 10 Pages: 2703-2708
- DOI
  10.1021/acs.jnatprod.6b00641
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148
[Journal Article] New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S0062016
- Author(s)
  Son S, Ko SK, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo IJ, Lee JS, Oh H, Hong YS, Kim BY, Takahashi S, Osada H, Jang JH, Ahn JS.
- Journal Title
  
  Mar Drugs
  
  Volume: 14 Issue: 4 Pages: 72-72
- DOI
  10.3390/md14040072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library2016
- Author(s)
  Lim CL., Nogawa T., Okano A., Futamura Y., Kawatani M., Takahashi S. Ibrahim D., Osada H.
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: AOP Issue: 6 Pages: 456-458
- DOI
  10.1038/ja.2015.124
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941
[Journal Article] Identification of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoA for polyketide extender unit2015
- Author(s)
  Miyazawa T., Takahashi S., Kawata A., Panthee S., Hayashi T., Shimizu T., Nogawa T., Osada H.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 290 Issue: 45 Pages: 26994-27011
- DOI
  10.1074/jbc.m115.677195
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-24380052
[Journal Article] Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F0052015
- Author(s)
  Kim JW, Ko SK, Son S, Shin KS, Ryoo IJ, Hong YS, Oh H, Hwang BY, Hirota H, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 25 Issue: 22 Pages: 5398-5401
- DOI
  10.1016/j.bmcl.2015.09.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270.2015
- Author(s)
  Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS, Osada H.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 68 Issue: 4 Pages: 293-295
- DOI
  10.1038/ja.2014.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24619011, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445
[Journal Article] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.2015
- Author(s)
  Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 460 Issue: 2 Pages: 210-215
- DOI
  10.1016/j.bbrc.2015.03.011
- NAID
  130007491120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PUBLICLY-25108725, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445
[Journal Article] Detection of oxygen addition peaks for terpendole E and related indole-diterpene alkaloids in a positive-mode ESI-MS2014
- Author(s)
  Hongo, Y., Nakamura, T., Takahashi, S., Motoyama, T., Hayashi, T., Hirota, H., Osada, H., and Koshino, H.
- Journal Title
  
  Journal of Mass Spectrometry
  
  Volume: 49 Issue: 12 Pages: 537-542
- DOI
  10.1038/ja.2014.80
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23580125, KAKENHI-PROJECT-24380052, KAKENHI-PUBLICLY-25108721
[Journal Article] Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T2014
- Author(s)
  Shunji Takahashi, Shingo Nagano, Toshihiko Nogawa, Naoki Kanoh, Masakazu Uramoto, Makoto Kawatani, Yoshitsugu Shiro, Hiroyuki Osada
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 47 Pages: 32446-32458
- DOI
  10.1074/jbc.m114.598391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102013, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25291015, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26450148
[Journal Article] RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.2014
- Author(s)
  Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 67 Issue: 4 Pages: 323-329
- DOI
  10.1038/ja.2013.144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24619011, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726
[Journal Article] リベロマイシンA生合成に関わる未知酵素の解明－スピロアセタール環化酵素の発見2013
- Author(s)
  高橋俊二、長田裕之
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 138-140
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108726
[Journal Article] リベロマイシンA生合成に関わる未知酵素の解明－スピロアセタール環化酵素の発見2013
- Author(s)
  高橋俊二、長田裕之
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 138-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658088
[Journal Article] Creation of novel reveromycin derivatives by alcohol added fermentation2013
- Author(s)
  Nogawa T. et al.
- Journal Title
  
  J. Antibiot.
  
  Volume: 66 Issue: 4 Pages: 247-250
- DOI
  10.1038/ja.2012.115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25350981
[Journal Article] A Point Mutation in ftmD Blocks the Fumitremorgin Biosynthetic Pathway in Aspergillus fumigatus Strain Af2932013
- Author(s)
 Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
- Journal Title
 
 Bioscience, Biotechnology, and Biochemistry
 
 Volume: 77 Issue: 5 Pages: 1061-1067
- DOI
 10.1271/bbb.130026
- NAID
 10031177597
- ISSN
 0916-8451, 1347-6947
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108725, KAKENHI-PUBLICLY-25108726
[Journal Article] Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus.2013
- Author(s)
  Nogawa T, Kawatani M, Uramoto M, Okano A, Aono H, Futamura Y, Koshino H, Takahashi S, Osada H.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 66 Issue: 10 Pages: 621-623
- DOI
  10.1038/ja.2013.55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25350981
[Journal Article] リベロマイシンA生合成に関わる未知酵素の解明－スピロアセタール環化酵素の発見2013
- Author(s)
  高橋俊二、長田裕之
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 138-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380052
[Journal Article] リベロマイシンA生合成に関わる未知酵素の解明-スピロアセタール環化酵素の発見2013
- Author(s)
  高橋俊二、長田裕之
- Journal Title
  
  化学と生物
  
  Volume: Vol.51,No.3 Pages: 138-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658088
[Journal Article] Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library2012
- Author(s)
  Nogawa T
- Journal Title
  
  J.Antibiot.
  
  Volume: (In press) Issue: 3 Pages: 123-128
- DOI
  10.1038/ja.2011.121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104, KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088
[Journal Article] Spirotoamides A and B, novel 6, 6-spiroacetal polyketides isolated from a microbial metabolite fraction library2012
- Author(s)
  Nogawa T., Takahashi S., Okano A., Kawatani M., Uramoto M., Saito T., and Osada H
- Journal Title
  
  J. Antibiot
  
  Volume: 65(3) Pages: 123-128
- NAID
  10030711040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Improvement of transformation efficiency by strategic circumvention of restriction barriers in Streptomyces griseus2011
- Author(s)
  Suzuki H, Takahashi S, Osada H, and Yoshida K
- Journal Title
  
  J. Microbiol. Biotechnol
  
  Volume: 21(7) Pages: 675-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation2011
- Author(s)
  Takahashi S
- Journal Title
  
  Nat.Chem.Biol.
  
  Volume: 7 Issue: 7 Pages: 461-468
- DOI
  10.1038/nchembio.583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104, KAKENHI-PLANNED-22108006, KAKENHI-PLANNED-22108010
[Journal Article] Detection of cytochrome P450 substrates using small-molecule droplet array on NADH-immobilized solid surface2011
- Author(s)
  Takayama H, Takahashi S, Osada H, Iwabuchi Y, and Kanoh N
- Journal Title
  
  Chembiochem
  
  Volume: 12(18) Pages: 2748-2752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Genetic safeguard against mycotoxin cyclopiazonic acid production in Aspergillus oryzae2011
- Author(s)
  Kato N., Tokuoka M., Shinohara Y., Kawatani M., Uramoto M., Seshime Y., Fujii I., Kitamoto K., Takahashi T., Takahashi S., Koyama Y., and Osada H
- Journal Title
  
  Chembiochem
  
  Volume: 12(9) Pages: 1376-1382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Furaquinocins I and J : Novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-5932011
- Author(s)
  Panthee S, Takahashi S, Takagi H, Nogawa T, Oowada E, Uramoto M, and Osada H
- Journal Title
  
  J. Antibiot
  
  Volume: 64(7) Pages: 509-513
- NAID
  10030639617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Gene disruption and biochemical characterization of verruculogen synthase of Aspergillus fumigates2011
- Author(s)
  Kato N, Suzuki H, Takagi H, Uramoto M, Takahashi S., and Osada H
- Journal Title
  
  Chembiochem
  
  Volume: 12(5) Pages: 711-714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation2011
- Author(s)
  Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y, and Osada H
- Journal Title
  
  Nat. Chem. Biol
  
  Volume: 7 Pages: 461-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp. SN-5932010
- Author(s)
  Takahashi S., Takagi H., Toyoda A., Uramoto M., Nogawa T., Ueki M., Sakaki Y. and Osada H
- Journal Title
  
  J. Bacteriol
  
  Volume: 192(11) Pages: 2839-2851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Verticilactam, a New Macrolactam isolated from a microbial metabolite fraction library2010
- Author(s)
  Nogawa T., Okano A., Takahashi S., Uramoto M., Konno H., Saito T., and Osada H
- Journal Title
  
  Org. Lett
  
  Volume: 12(20) Pages: 4564-4567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua2010
- Author(s)
  Ryden A. M., Ruyter-Spira C., Litjens R., Takahashi S., Quax W., Osada H., Bouwmeester H., Kayser O
- Journal Title
  
  Plant Cell Physiol
  
  Volume: 51(7) Pages: 1219-1228
- NAID
  10027351030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp.SN-5932010
- Author(s)
  Takahashi S.
- Journal Title
  
  J.Bacteriol.
  
  Volume: 192 Pages: 2839-2851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp. SN-593.2010
- Author(s)
  Takahashi, S. (8名中1番目), Osada, H. (8名中8番目)
- Journal Title
  
  J. Bacteriol. 192
  
  Pages: 2839-2851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis2009
- Author(s)
  Hashimoto M., Higuchi Y., Takahashi S., Osada H., Sakaki T., Toyomasu T., Sassa T., Kato N. and Dairi T
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 19(19) Pages: 5640-5643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Journal Article] Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.2009
- Author(s)
  Kakeya, H. (10名中5番目), Usui, T. (10名中7番目), Takahashi, S. (10名中8番目), Osada, H. (10名中10番目)
- Journal Title
  
  Chembiochem 23
  
  Pages: 920-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis.2009
- Author(s)
  Takahashi, S. (9名中3番目), Osada, H. (9名中4番目)
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19
  
  Pages: 5640-5643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus2009
- Author(s)
  Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S., Sugimoto Y and Osada H
- Journal Title
  
  Chembiochem
  
  Volume: 10(5) Pages: 920-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580104
[Patent] ポリケチド化合物の製造方法2011
- Inventor(s)
  長田裕之、高橋俊二、清水猛、林輝雄
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2011-178620
- Filing Date
  2011-08-17
- Data Source
  KAKENHI-PROJECT-21580104
[Patent] リベロマイシンAまたはその生合成中間体の製造法およびスピロケタール環含有化合物の製造方法2010
- Inventor(s)
  長田裕之、高橋俊二、榊佳之、豊田敦
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2010-194222
- Filing Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Iron-sulfur protein catalyzed [4+2] cycloadditions in verticilactam biosynthesis2024
- Author(s)
  Yu Zheng, Katsuyuki Sakai, Kohei Watanabe, Hiroshi Takagi, Yumi Sato-Shiozaki, Yuko Misumi, Yohei Miyanoiri, Genji Kurisu, Toshihiko Nogawa, Ryo Takita, Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] 異種発現Streptomyces lividans TK23を利用した新規アンスラキノン化合物の取得2024
- Author(s)
  坂井克行、二村友史、野川俊彦、越野広雪、長田裕之、高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Expression of Syo_1.56 SARP Regulator Unveils Potent Elasnin Derivatives with Antibacterial Activity2024
- Author(s)
  Islam Adel Abdelhakim Amin, Yushi Futamura, Yukihiro Asami, Hideaki Hanaki, Naoko Kito, Sachiko Masuda, Arisa Shibata, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, and Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Expression of Syo_1.56 SARP Regulator Unveils Potent Elasnin Derivatives with Antibacterial Activity2024
- Author(s)
  Islam Adel Abdelhakim Amin, Yushi Futamura, Yukihiro Asami, Hideaki Hanaki, Naoko Kito, Sachiko Masuda, Arisa Shibata, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, and Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Elucidation of [4+2] cycloaddition reaction involved in verticilactam biosynthesis2024
- Author(s)
  Shunji Takahashi
- Organizer
  8th USM-RIKEN Symposium
- Invited
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] 異種発現Streptomyces lividans TK23を利用した新規アンスラキノン化合物の取得2024
- Author(s)
  坂井克行、二村友史、野川俊彦、越野広雪、長田裕之、高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Elucidation of [4+2] cycloaddition reaction involved in verticilactam biosynthesis Shunji Takahashi2024
- Author(s)
  Shunji Takahashi
- Organizer
  8th USM-RIKEN Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Iron-sulfur protein catalyzed [4+2] cycloadditions in verticilactam biosynthesis2024
- Author(s)
  Yu Zheng, Katsuyuki Sakai, Kohei Watanabe, Hiroshi Takagi, Yumi Sato-Shiozaki, Yuko Misumi, Yohei Miyanoiri, Genji Kurisu, Toshihiko Nogawa, Ryo Takita, Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Engineering of cytochrome P450 for synthesis of novel reveromycin derivatives.2023
- Author(s)
  Ya Fen Yong, Song Liu, Katsuyuki Sakai, Hiroshi Takagi, Boon Beng Eugene Ong, Hiroyuki sada, and Shunji Takahashi
- Organizer
  日本薬物動態学会第38 回年会／第23 回シトクロムP450 国際会議国際合同大会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Crystal structure analysis of drimenol synthase from marine bacterium.2023
- Author(s)
  Keisuke FUJIYAMA, Vo Ngoc Quynh NHU, Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Biosynthesis of verticilactams produced by Streptomyces spiroverticillatus JC-8444.2023
- Author(s)
  Yu Zheng, Katsuyuki Sakai, Hiroshi Takagi, Yumi Shiozaki-Sato, Toshihiko Nogawa, and Shunji Takahashi
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Biosynthesis of verticilactams produced by Streptomyces spiroverticillatus JC-84442023
- Author(s)
  Yu Zheng, Katsuyuki Sakai, Hiroshi Takagi, Yumi Shiozaki-Sato, Toshihiko Nogawa, and Shunji Takahashi
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Biosynthetic study of verticilactam, a polycyclic macrolactam from Streptomyces2023
- Author(s)
  Yu ZHENG, Katsuyuki SAKAI, Hiroshi TAKAGI, Yumi SHIOZAKI-SATO, Toshihiko NOGAWA, Shunji TAKAHASHI
- Organizer
  4th International Conference on Natural Products Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Crystal structure analysis of drimenol synthase from marine bacterium.2023
- Author(s)
  Keisuke FUJIYAMA, Vo Ngoc Quynh NHU, Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Production of natural products by heterologous gene expression2023
- Author(s)
  Shunji Takahashi
- Organizer
  The 5th KRIBB-RIKEN Chemical Biology Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Biosynthetic study of verticilactam, a polycyclic macrolactam from Streptomyces2023
- Author(s)
  Yu ZHENG, Katsuyuki SAKAI, Hiroshi TAKAGI, Yumi SHIOZAKI-SATO, Toshihiko NOGAWA, Shunji TAKAHASHI
- Organizer
  4th International Conference on Natural Products Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Identification of new lucilactaene derivatives with potent antimalarial activity2023
- Author(s)
  Yushi Futamura, Islam A Abdelhakim, Takayuki Motoyama, Fauze Bin Mahmud, Harumi Aono, Nobumoto Watanabe, Shunji Takahashi, Kuniki Kino, Hiroyuki Osada
- Organizer
  4th International Conference on Natural Products Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Crystal structure analysis of drimenol synthase from marine bacterium.2023
- Author(s)
  Keisuke FUJIYAMA, Vo Ngoc Quynh NHU, Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Biosynthetic study of verticilactam, a polycyclic macrolactam from Streptomyces2023
- Author(s)
  Yu ZHENG, Katsuyuki SAKAI, Hiroshi TAKAGI, Yumi SHIOZAKI-SATO, Toshihiko NOGAWA, Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Engineering of cytochrome P450 for synthesis of novel reveromycin derivatives.2023
- Author(s)
  Ya Fen Yong, Song Liu, Katsuyuki Sakai, Hiroshi Takagi, Boon Beng Eugene Ong, Hiroyuki Osada, and Shunji Takahashi
- Organizer
  日本薬物動態学会第38 回年会／第23 回シトクロムP450 国際会議国際合同大会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] 海洋バクテリア由来ドリメノール合成酵素の構造基盤2023
- Author(s)
  藤山　敬介、髙木　海、Nhu Ngoc Quynh Vo、高橋　俊二
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Structural basis for a marine bacterial drimenol synthase with none canonical domain assembly for terpene synthase2023
- Author(s)
  藤山　敬介、髙木　海、Nhu Ngoc Quynh Vo、高橋　俊二
- Organizer
  日本タンパク質科学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] 遺伝子改変糸状菌より収集したデカリン含有テトラミン酸化合物の構造活性相関2023
- Author(s)
  加藤直樹，野川俊彦，海老原佳奈，二村友史，松田一彦，丹羽隆介，高橋俊二，長田裕之
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] New elasnin derivatives identified by expression of a SARP family regulatory gene.2023
- Author(s)
  Islam Amin, Jun Ishikawa, Sachiko Masuda, Ken Shirasu, Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] 異種発現系を用いた新規kinanthraquinone類の取得と生合成機構の解明2023
- Author(s)
  坂井克行, 二村友史, 越野広雪, 長田裕之, 高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] 海洋バクテリア由来ドリメノール合成酵素の構造基盤2023
- Author(s)
  藤山　敬介、髙木　海、Nhu Ngoc Quynh Vo、高橋　俊二
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] 異種発現系を用いた新規kinanthraquinone類の取得と生合成機構の解明2023
- Author(s)
  坂井克行, 二村友史, 越野広雪, 長田裕之, 高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Expression of SYO_1.56 SARP Regulator Unveils Unprecedented Elasnin Derivatives with Remarkable Antibacterial Activity.2023
- Author(s)
  Islam A. Abdelhakim, Yushi Futamura, Naoko Kito, Arisa Shibata, Sachiko Masuda, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, and Shunji Takahashi
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Aminoacylation in the biosynthesis of ascamycin2023
- Author(s)
  Yu Zheng, Naoko Morita, Hiroshi Takagi, Yumi Sato, Kazuo Shin-ya, Shunji Takahashi
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Aminoacylation in the biosynthesis of ascamycin2023
- Author(s)
  Yu Zheng, Naoko Morita, Hiroshi Takagi, Yumi Sato, Kazuo Shin-ya, Shunji Takahashi
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Production of natural products by heterologous gene expression2023
- Author(s)
  Shunji Takahashi
- Organizer
  The 5th KRIBB-RIKEN Chemical Biology Joint Symposium
- Invited
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi, and Shunji Takahashi2023
- Author(s)
  Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi, and Shunji Takahashi
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Identification of new lucilactaene derivatives with potent antimalarial activity2023
- Author(s)
  Yushi Futamura, Islam A Abdelhakim, Takayuki Motoyama, Fauze Bin Mahmud, Harumi Aono, Nobumoto Watanabe, Shunji Takahashi, Kuniki Kino, Hiroyuki Osada
- Organizer
  4th International Conference on Natural Products Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Expression of SYO_1.56 SARP Regulator Unveils Unprecedented Elasnin Derivatives with Remarkable Antibacterial Activity.2023
- Author(s)
  Islam A. Abdelhakim, Yushi Futamura, Naoko Kito, Arisa Shibata, Sachiko Masuda, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, and Shunji Takahashi
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Reveromycin A生合成酵素RevK-RevL複合体モデル構造に基づくRevL変異導入酵素の解析と相互作用領域決定2023
- Author(s)
  岡村英治、佐藤（汐﨑）裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Analysis P450 reactions involved in natural product biosynthesis in Streptomyces2023
- Author(s)
  Shunji Takahashi
- Organizer
  日本薬物動態学会第38 回年会／第23 回シトクロムP450 国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] Analysis P450 reactions involved in natural product biosynthesis in Streptomyces2023
- Author(s)
  Shunji Takahashi
- Organizer
  日本薬物動態学会第38 回年会／第23 回シトクロムP450 国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] New elasnin derivatives identified by expression of a SARP family regulatory gene.2023
- Author(s)
  Islam Amin, Jun Ishikawa, Sachiko Masuda, Ken Shirasu, Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Structural basis for a marine bacterial drimenol synthase with none canonical domain assembly for terpene synthase2023
- Author(s)
  藤山　敬介、髙木　海、Nhu Ngoc Quynh Vo、高橋　俊二
- Organizer
  日本タンパク質科学会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Biosynthetic study of verticilactam, a polycyclic macrolactam from Streptomyces2023
- Author(s)
  Yu ZHENG, Katsuyuki SAKAI, Hiroshi TAKAGI, Yumi SHIOZAKI-SATO, Toshihiko NOGAWA, Shunji TAKAHASHI
- Organizer
  4th International Conference on Natural Products Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] Discovery and characterization of novel bifunctional drimane-type sesquiterpene synthases in marine bacteria2023
- Author(s)
  Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi, and Shunji Takahashi
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-23H04564
[Presentation] New elasnin derivatives identified by expression of a SARP family regulatory gene.2023
- Author(s)
  Islam Amin, Jun Ishikawa, Sachiko Masuda, Ken Shirasu, Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Biosynthetic study of verticilactam, a polycyclic macrolactam from Streptomyces2023
- Author(s)
  Yu ZHENG, Katsuyuki SAKAI, Hiroshi TAKAGI, Yumi SHIOZAKI-SATO, Toshihiko NOGAWA, Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Aspergillus 糸状菌におけるアミラーゼ生産を誘導する代謝耐性イソマルトースアナログ2022
- Author(s)
  沼本穂，森山貴博，田邉理子，寄立麻琴，平井剛，高橋俊二，加藤直樹
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] デカリン合成酵素の阻害剤同定と共結晶構造解析2022
- Author(s)
  加藤直樹，藤山敬介，永野真吾，高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] デカリン合成酵素の阻害剤同定と共結晶構造解析2022
- Author(s)
  加藤直樹，藤山敬介，永野真吾，高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Functional characterization of a novel bifunctional drimenol synthase of bacterial origin: A step toward the discovery of drimane sesquiterpenes in bacteria2022
- Author(s)
  Nhu Ngoc Quynh Vo，Yuhta Nomura，Kiyomi Kinugasa， Hiroshi Takagi，Yumi Shiozaki-Sato，Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Mode of action study of dihydrolucilactaene，a new highly potent antimalarial compound2022
- Author(s)
  Fauze Mahmud，Futamura Yushi， Islam A. Abdelhakim，Motoyama Takayuki， Takahashi Shunji，Ngit Shin Lai，Osada Hiroyuki
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Discovery of novel bifunctional drimane sesquiterpene synthases from marine bacteria.2022
- Author(s)
  Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi, Yumi Shiozaki-Sato, and Shunji Takahashi
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22KK0080
[Presentation] 生合成モジュールの機能解析に向けたPikromycin 生合成中間体の合成研究2022
- Author(s)
  大澤宏祐、伴秀俊、杉山良幸、岡村英治、高橋俊二、土井隆行
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Characterization of cytochrome P450 function in verticilactam biosynthesis2022
- Author(s)
  Yu ZHENG，Hiroshi TAKAGI，Katsuyuki SAKAI，Yumi SHIOZAKI-SATO，Toshihiko NOGAWA， Risa TAKAO，Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Discovery of novel bifunctional drimane sesquiterpene synthases from marine bacteria.2022
- Author(s)
  Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi, Yumi Shiozaki-Sato, and Shunji Takahashi
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Discovery of new lucilactaene derivatives with potent antimalarial activity and their structure-activity relationship2022
- Author(s)
  Islam Adel Abdelhakim Amin，Fauze Mahmud， Motoyama Takayuki，Nogawa Toshihiko，Futamura Yushi， Takahashi Shunji，Osada Hiroyuki
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Characterization of cytochrome P450 function in verticilactam biosynthesis2022
- Author(s)
  Yu ZHENG，Hiroshi TAKAGI，Katsuyuki SAKAI， Yumi SHIOZAKI-SATO，Toshihiko NOGAWA， Risa TAKAO，Shunji TAKAHASHI
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] リベロマイシンA生合成に関わる複合酵素の鍵相互作用残基の同定2022
- Author(s)
  岡村英治、佐藤（汐﨑）裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] リベロマイシンA生合成に関わる複合酵素の鍵相互作用残基の同定2022
- Author(s)
  岡村英治、佐藤（汐﨑）裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Identification of elasnin derivatives by expression of regulatory gene2022
- Author(s)
  Islam A. Abdelhakim, Naoko Kito, Sachiko Masuda, Ken Shirasu, Jun Ishikawa, and Shunji Takahashi
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Discovery of new lucilactaene derivatives with potent antimalarial activity and their structure-activity relationship2022
- Author(s)
  Islam Adel Abdelhakim Amin，Fauze Mahmud， Motoyama Takayuki，Nogawa Toshihiko，Futamura Yushi， Takahashi Shunji，Osada Hiroyuki
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Identification of elasnin derivatives by expression of regulatory gene2022
- Author(s)
  Islam A. Abdelhakim, Naoko Kito, Sachiko Masuda, Ken Shirasu, Jun Ishikawa, and Shunji Takahashi
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] Functional characterization of a novel bifunctional drimenol synthase of bacterial origin: A step toward the discovery of drimane sesquiterpenes in bacteria2022
- Author(s)
  Nhu Ngoc Quynh Vo，Yuhta Nomura，Kiyomi Kinugasa，Hiroshi Takagi，Yumi Shiozaki-Sato，Shunji Takahashi
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] ReveromycinA生合成酵素RevKLMのin sillico解析による相互作用予測と実験的検証2022
- Author(s)
  岡村英治，佐藤（汐﨑）裕美，奥村英夫，熊坂崇，長田裕之，高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] ReveromycinA生合成酵素RevKLMのin sillico解析による相互作用予測と実験的検証2022
- Author(s)
  岡村英治，佐藤（汐﨑）裕美，奥村英夫，熊坂崇，長田裕之，高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] デカリン合成酵素Phm7およびFsa2のin vitroアッセイ系の構築2021
- Author(s)
  加藤直樹、藤山敬介、野川俊彦、長田裕之、永野真吾、高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] 放線菌の二次代謝生合成機構と生産性増強に関する研究2021
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] デカリン合成酵素Phm7およびFsa2のin vitroアッセイ系の構築2021
- Author(s)
  加藤直樹、藤山敬介、野川俊彦、長田裕之、永野真吾、高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] 非典型OmpRレスポンスレギュレーターを用いたkinanthraquinone生産改善と生合成中間体の取得2021
- Author(s)
  高尾理沙, 坂井克行, 越野広雪, 長田裕之, 高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] Analysis of verticilactam biosynthetic gene cluster2021
- Author(s)
  Toshihiko Nogawa, Atsutaka Terai, Keita Amagai, Junko Hashimoto, Manabu Fujie, Noriyuki Satoh, Haruo Ikeda, Kazuo Shin-ya, Hiroyuki Osada, Shunji Takahashi
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] 非典型OmpRレスポンスレギュレーターを用いたkinanthraquinone生産改善と生合成中間体の取得2021
- Author(s)
  高尾理沙, 坂井克行, 越野広雪, 長田裕之, 高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PROJECT-20H00416
[Presentation] 放線菌の二次代謝生合成機構と生産性増強に関する研究2021
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19099
[Presentation] 一次代謝関連遺伝子の導入によるリベロマイシン生産改善2020
- Author(s)
  高木海、白井智量、岡村英治、近藤昭彦、長田裕之、高橋俊二
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] BACを利用した200 kb を超えるquinoliidomicin生合成遺伝子クラスターの異種発現2020
- Author(s)
  橋本拓哉、橋本絢子、小曽根郁子、酒井紀子、高橋俊二、池田治生、新家一男
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] 放線菌異種発現によるverticilactam新規類縁体の生産と単離・構造決定2020
- Author(s)
  野川俊彦、寺井淳高、新家一男、池田治生、高橋俊二、長田裕之
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の相互作用解析2019
- Author(s)
  鬼頭奈央子、佐藤裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の相互作用解析2019
- Author(s)
  鬼頭奈央子、佐藤裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるRevKの結晶構造解析2019
- Author(s)
  奥村英夫、鬼頭奈央子、佐藤裕美、熊坂崇、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] Identification of the pyrrolizilactone biosynthetic gene cluster in Pleosporales sp. RKB35642019
- Author(s)
  Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Hiroyuki Osada, Shunji Takahashi
- Organizer
  第10回　日韓ケミカルバイオロジーシンポジウム
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-5932019
- Author(s)
  Shunji Takahashi
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] リベロマイシン生合成に関わるサクシニル転移酵素の機能解析2019
- Author(s)
  鬼頭奈央子、佐藤裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  日本放線菌学会
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-5932019
- Author(s)
  Shunji Takahashi
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] 新規複合糖質研究ツール２：代謝耐性型糖鎖アナログの簡便合成とその機能2019
- Author(s)
  平井剛、木谷憲昭、加藤直樹、日高悠、森山貴博、臼井一晃、寄立麻琴、高橋俊二
- Organizer
  糖質学会
- Data Source
  KAKENHI-PUBLICLY-19H04666
[Presentation] リベロマイシン生合成に関わるRevKの結晶構造解析2019
- Author(s)
  奥村英夫、鬼頭奈央子、佐藤裕美、熊坂崇、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価2018
- Author(s)
  髙木　海、野川俊彦、二村友史、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018
- Author(s)
  鬼頭奈央子、高橋　俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 立体選択的デカリン形成を担うFsa2ファミリーDiels-Alderaseの機能解析2018
- Author(s)
  加藤直樹、野川俊彦、衣笠清美、高橋俊二、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Crystal Structures of an Indole Prenyltransferase, IptA: Implications for Substrate Tolerance and Its Expansion2018
- Author(s)
  西本一希、日野智也、高木　海、佐藤裕美、高橋俊二、永野真吾
- Organizer
  24th Conference on Isoprenoids
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価2018
- Author(s)
  髙木　海、野川俊彦、二村友史、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造2018
- Author(s)
  野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] Kinanthraquinone生合成遺伝子クラスターの解析2018
- Author(s)
  高尾理沙、鬼頭奈央子、高木海、野川俊彦、長田裕之、高橋俊二
- Organizer
  放線菌学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] Kinanthraquinone生合成遺伝子クラスターの解析2018
- Author(s)
  高尾理沙、鬼頭奈央子、高木海、野川俊彦、長田裕之、高橋俊二
- Organizer
  放線菌学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] 立体選択的デカリン形成を担うFsa2ファミリーDiels-Alderaseの機能解析2018
- Author(s)
  加藤直樹、野川俊彦、衣笠清美、高橋俊二、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造2018
- Author(s)
  野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価2018
- Author(s)
  高木海、野川俊彦、二村友史、長田裕之、高橋俊二
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018
- Author(s)
  鬼頭奈央子、佐藤裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  放線菌学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] 立体選択的デカリン形成を担うFsa2ファミリーDiels-Alderaseの機能解析2018
- Author(s)
  加藤直樹、野川俊彦、衣笠清美、高橋俊二、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造2018
- Author(s)
  野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成に関わる酸化還元酵素RevMの機能解析2017
- Author(s)
  鬼頭奈央子, 高橋俊二, 宮澤岳, 前島希, 田中美帆, 室井誠. 奥村英夫, 熊坂崇, 長田裕之
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成に関わる酸化還元酵素RevMの機能解析2017
- Author(s)
  鬼頭奈央子、高橋俊二、宮澤岳、前島希、田中美帆、室井誠、奥村英夫、熊坂崇、長田裕之
- Organizer
  農芸化学会
- Place of Presentation
  京都（京都女子大）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] Fsa2-family Diels-Alderases are responsible for the stereoselective decaline formation2017
- Author(s)
  Naoki Kato, Toshihiko Nogawa, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
- Organizer
  3rd KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物の構造2017
- Author(s)
  野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 麹菌Aspergillus oryzaeが有する新奇セスキテルペン生合成経路の解明2017
- Author(s)
  篠原靖智，高橋俊二，長田裕之，小山泰二
- Organizer
  農芸化学会
- Place of Presentation
  京都（京都女子大）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] プレニル化インドールアルカロイドokaramine生合成におけるazetidine環合成酵素の同定2017
- Author(s)
  加藤直樹, 大髙潤之介, 衣笠清美, 古谷章悟, 高橋俊二, 松田一彦, 長田裕之
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成に関わるRevMの結晶構造解析2017
- Author(s)
  奥村英夫, 鬼頭奈央子, 高橋俊二, 宮澤岳, 熊坂崇, 長田裕之
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Application of a fraction library for new metabolites search2017
- Author(s)
  Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Nobumoto Watanabe, Shunji Takahashi, Hiroyuki Osada
- Organizer
  3rd KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成に関わるRevMの機能解析2017
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  放線菌学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] Development of terpenoid production platform using Streptomyces reveromyceticus2017
- Author(s)
  Ammara Khalid, Hiroshi Takagi, Suresh Panthee, Hiroyuki Osada, and Shunji Takahashi.
- Organizer
  農芸化学会
- Place of Presentation
  京都（京都女子大）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] Identification of novel anthraquinone biosynthetic gene cluster2017
- Author(s)
  Risa Takao, Naoko Kito, Hiroshi Takagi, Hiroyuki Osada, Shunji Takahashi
- Organizer
  3rd KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Identification of pyrrolizilactone biosynthetic gene cluster of the fungus RKB35642017
- Author(s)
  Sayaka Hirosawa, Naoki Kato, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
- Organizer
  3rd KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成に関わるRevMの機能解析2017
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  第32回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Regulation of Reveromycin Biosynthetic Gene Cluster by Small Molecule2017
- Author(s)
  Shunji Takahashi
- Organizer
  18th International Symposium on the Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるRevMの機能解析2017
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  放線菌学会
- Data Source
  KAKENHI-PUBLICLY-17H05455
[Presentation] ストレプトマイセス　リベロマイセティカスを用いたテルペノイド生産プラットフォームの開発2017
- Author(s)
  ＡＭＭＡＲＡＫＨＡＬＩＤ, 高木海, ＳＵＲＥＳＨＰＡＮＴＨＥＥ, 長田裕之, 高橋俊二
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] プレニル化インドールアルカロイドokaramineの遺伝学的手法による生合成経路解析2016
- Author(s)
  加藤直樹, 古谷章悟, 大髙潤之介, 衣笠清美, 高橋俊二, 松田一彦, 長田裕之
- Organizer
  日本農芸化学会 2016年度大会
- Place of Presentation
  札幌コンベンションセンター札幌市産業振興センター（北海道札幌市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Characterization of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoAs for polyketide extender unit2016
- Author(s)
  Miyazawa H, Takahashi S, Shimizu T, Nogawa T, Osada H
- Organizer
  The 8th Korea-Japan Chemical Biology symposium
- Place of Presentation
  Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Discovery of a new enzyme involved in the stereoselective decalin formation during equisetin biosynthesis2016
- Author(s)
  Kato N, Nogawa T, Hirota H, Takahashi S, Jang JH, Ahn JS, Osada H
- Organizer
  The 8th Korea-Japan Chemical Biology symposium
- Place of Presentation
  Pacific Hotel Okinawa（Naha, Okinawa）
- Year and Date
  2016-01-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] アミノ酸置換による新規テロメスタチン類縁体の創製2016
- Author(s)
  天貝啓太, 池田治生, 新家一男, 高橋俊二
- Organizer
  放線菌学会
- Place of Presentation
  東京大学
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] 微生物フラクションライブラリーより単離した新規ネオアンチマイシン類縁体ウナンチマイシンAの構造2016
- Author(s)
  野川俊彦, リム・チュンリャン, 岡野亜紀子, 二村友史, 川谷誠, 高橋俊二, ダーラ・イブラヒム, 長田裕之
- Organizer
  日本農芸化学会 2016年度大会
- Place of Presentation
  札幌コンベンションセンター札幌市産業振興センター（北海道札幌市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Characterization of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoAs for polyketide extender unit2016
- Author(s)
  Miyazawa H, Takahashi S, Shimizu T, Nogawa T, Osada H
- Organizer
  The 8th Korea-Japan Chemical Biology symposium
- Place of Presentation
  Pacific Hotel Okinawa （Naha, Okinawa）
- Year and Date
  2016-01-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Verticilactam生合成遺伝子クラスター異種発現による新規類縁体の同定2016
- Author(s)
  ○高橋俊二 , 寺井淳高, 野川俊彦, 天貝啓太, 二村友史、橋本絢子, 新家一男, 池田治生, 川崎寿, 長田裕之
- Organizer
  日本農芸化学会
- Place of Presentation
  札幌コンベンションセンター　（札幌）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] フサリセチンAの特徴的な環構造形成を担う環化酵素の同定2016
- Author(s)
  加藤直樹, 衣笠清美，Jae-Hyuk JANG，高橋俊二，Jong Seog AHN，長田裕之
- Organizer
  第16回糸状菌分子生物学コンファレンス
- Place of Presentation
  宇治おうばくプラザ（京都大学宇治キャンパス内）（京都府宇治市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Discovery of a new enzyme involved in the stereoselective decalin formation during equisetin biosynthesis2016
- Author(s)
  Kato N, Nogawa T, Hirota H, Takahashi S, Jang JH, Ahn JS, Osada H
- Organizer
  The 8th Korea-Japan Chemical Biology symposium
- Place of Presentation
  Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 放線菌Streptomyces sp. RK88-1355より単離した新規Opantimycin Aの構造2016
- Author(s)
  野川俊彦, リム・チュンリャン, 岡野亜紀子, 二村友史, 清水猛, 高橋俊二, 長田裕之
- Organizer
  第58回天然有機化合物討論会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis2015
- Author(s)
  Naoki Kato, Toshihiko Nogawa, Hiroshi Hirota, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn, Hiroyuki Osada
- Organizer
  The international chemical congress of pacific basin societies (Pacifichem) 2015
- Place of Presentation
  Hawaii Convention Center 他（Honolulu, Hawaii, USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] ポリケチド伸長単位生合成に関与する脂肪酸活性化酵素の機能解析2015
- Author(s)
  宮澤岳、高橋俊二、長田裕之
- Organizer
  放線菌学会
- Place of Presentation
  富山国際会議場　（富山）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Characterization of fatty acyl-CoA ligase for the biosynthesis of the extender unit of reveromycin A2015
- Author(s)
  Shunji Takahashi, Takeshi Miyazawa, Hiroyuki Osada
- Organizer
  The international chemical congress of pacific basin societies (Pacifichem) 2015
- Place of Presentation
  Hawaii Convention Center 他（Honolulu, Hawaii, USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 昆虫制御活性物質オカラミンの生合成遺伝子クラスターの同定2015
- Author(s)
  加藤直樹, 古谷章悟，衣笠清美，高橋俊二，松田一彦，長田裕之
- Organizer
  第15回糸状菌分子生物学コンファレンス
- Place of Presentation
  ルミエール府中（東京都府中市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Streptomyces reveromyceticusにおけるテルペノイド生合成プラットフォーム2015
- Author(s)
  シュレスパンテー, アマラカーリッド, 高木海, 白井智量, 近藤昭彦, 長田裕之, 高橋俊二
- Organizer
  2015年度（第30回）日本放線菌学会大会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 遺伝子破壊実験によるテロメスタチン生合成遺伝子クラスターの同定2015
- Author(s)
  天貝啓太, 工藤史貴, 江口正, 長田裕之, 池田治生, 新家一男, 高橋俊二
- Organizer
  2015年度（第30回）日本放線菌学会大会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Terpenoid biosynthetic platform in Streptomyces reveromyceticus2015
- Author(s)
  Panthee　S, Khalid　A, Takagi　H, Shirai　T, Kondo　A, Osada　H and Takahashi　S
- Organizer
  放線菌学会
- Place of Presentation
  富山国際会議場　（富山）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] ポリケチド伸長単位生合成に関与する脂肪酸活性化酵素の機能解析2015
- Author(s)
  宮澤岳, 高橋俊二, 長田裕之
- Organizer
  2015年度（第30回）日本放線菌学会大会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] フラクションライブラリーとスペクトルデータベースを利用した新規化合物探索2015
- Author(s)
  野川俊彦, Jang Jun-Pil, Lim Chung Liang, 岡野亜紀子, 本郷やよい, 中村健道, 清水猛, 高橋俊二, 長田裕之
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば国際会議場エポルカつくば（茨城県つくば市）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Iolation of new metabolites from a microbial metabolites fraction library by NPPlot screening2015
- Author(s)
  Toshihiko Nogawa, Akiko Okano, Jang Jun-Pil, Takeshi Shimizu, Shunji Takahashi, Hiroyuki Osada
- Organizer
  The international chemical congress of pacific basin societies (Pacifichem) 2015
- Place of Presentation
  Hawaii Convention Center 他（Honolulu, Hawaii, USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] エキセチン生合成における立体選択的なデカリン環形成に関わる新規酵素遺伝子fsa2の発見2015
- Author(s)
  加藤直樹, 野川俊彦, 廣田洋, 高橋俊二, Jae-Hyuk Jang, Jong Seog Ahn, 長田裕之
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Biosynthesis study aiming at creation of an anti-osteoclast drug2015
- Author(s)
  Hiroyuki Osada, Toshihiko Nogawa, Shunji Takahashi
- Organizer
  The international chemical congress of pacific basin societies (Pacifichem) 2015
- Place of Presentation
  Hawaii Convention Center 他（Honolulu, Hawaii, USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] リベロマイシン生合成機構の解析2015
- Author(s)
  高橋俊二, 長田裕之
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  城山観光ホテル (鹿児島県鹿児島市)
- Year and Date
  2015-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 微生物の多様な代謝メカニズムと精巧な生合成マシーナリー2014
- Author(s)
  高橋俊二、長田裕之
- Organizer
  日本農芸化学会関東支部2014年度第一回例会シンポジウム
- Place of Presentation
  東京大学弥生講堂一条ホール
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] lucidation of reveromycin A biosynthesis2014
- Author(s)
  Shunji Takahashi et al.
- Organizer
  1st US-Japan Seminar on the Biosynthesis of Natural Products For Young Researcher
- Place of Presentation
  大岡山、東京
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Elucidation of reveromycin A biosynthesis2014
- Author(s)
  Shunji Takahashi et al.
- Organizer
  1st US-Japan Seminar on the Biosynthesis of Natural Products For Young Researcher
- Place of Presentation
  大岡山　東京
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Elucidation of reveromycin A biosynthesis2014
- Author(s)
 Takahashi S.
- Organizer
 1^<st> US-Japan Seminar on the Biosynthesis of Natural Products For Young Researcher
- Place of Presentation
 O-okayama, Tokyo
- Data Source
 KAKENHI-PROJECT-24658088
[Presentation] Elucidation of reveromycin A biosynthesis2014
- Author(s)
  Shunji Takahashi et al.
- Organizer
  1st US-Japan Seminar on the Biosynthesis of Natural Products For Young Researcher
- Place of Presentation
  O-okayama, Tokyo
- Data Source
  KAKENHI-PUBLICLY-25108726
[Presentation] In vitro reconstruction of reveromycin A biosythesis2014
- Author(s)
 Takahashi S.
- Organizer
 The 7^<th> Japan-Korea Chemical Biology Symposium
- Place of Presentation
 Jeju Island, Koera
- Data Source
 KAKENHI-PROJECT-24658088
[Presentation] In vitro reconstruction of reveromycin A biosythesis2014
- Author(s)
  Shunji Takahashi
- Organizer
  The 7thJapan-Korea Chemical Biology Symposium
- Place of Presentation
  Jeju Island, Koera
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108726
[Presentation] In vitro reconstruction of reveromycin A biosythesis2014
- Author(s)
  Shunji Takahashi
- Organizer
  The 7thJapan-Korea Chemical Biology Symposium
- Place of Presentation
  Jeju Island, Koera.
- Invited
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] In vitro reconstruction of reveromycin A biosythesis2014
- Author(s)
  Shunji Takahashi
- Organizer
  The 7thJapan-Korea Chemical Biology Symposium
- Place of Presentation
  Jeju Island, Koera.
- Invited
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] リベロマイシン生合成におけるサクシニル化機構の解析2013
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Analysis of Reveromycin A biosynthetic machinery2013
- Author(s)
  Shunji Takahashi,
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 2nd Symposium
- Place of Presentation
  和光、埼玉
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] リベロマイシン生合成研究から遺伝子クラスター覚醒小分子探索まで2013
- Author(s)
  高橋俊二
- Organizer
  JBA発酵と代謝研究会シンポジウム
- Place of Presentation
  東京大学、東京
- Invited
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] リベロマイシン生合成におけるサクシニル化機構の解析2013
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  仙台・東北大学
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Analysis of Reveromycin A biosynthetic machinery2013
- Author(s)
  Takahashi S.
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 2nd Symposium
- Place of Presentation
  Wako Saitama
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Analysis of Reveromycin A biosynthetic machinery2013
- Author(s)
  Shunji Takahashi et al.
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 2nd Symposium
- Place of Presentation
  和光、埼玉
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] リベロマイシン生合成研究から遺伝子クラスター覚醒小分子探索まで2013
- Author(s)
  高橋俊二
- Organizer
  JBA発酵と代謝研究会シンポジウム
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108726
[Presentation] Analysis of Reveromycin A biosynthetic machinery2013
- Author(s)
  Shunji Takahashi et al.
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 2nd Symposium
- Place of Presentation
  埼玉　和光
- Data Source
  KAKENHI-PUBLICLY-25108726
[Presentation] リベロマイシン生合成におけるサクシニル化機構の解析2013
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  仙台・東北大学
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] リベロマイシン生合成研究から遺伝子クラスター覚醒小分子探索まで2013
- Author(s)
  高橋俊二
- Organizer
  JBA発酵と代謝研究会シンポジウム
- Place of Presentation
  東京大学、東京
- Invited
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Exquisite control of Spiroacetal Formation in reveromycin A biosynthesis2012
- Author(s)
 高橋俊二
- Organizer
 The 6^<th> Korea-Japan Chemical Biology Symposium
- Place of Presentation
 札幌・定山渓(招待講演)
- Data Source
 KAKENHI-PROJECT-21580104
[Presentation] Structure and Function of P450revI in Reveromycin A Biosynthesis2012
- Author(s)
  高橋俊二
- Organizer
  チトクロムP450発見50周年記念シンポジウム
- Place of Presentation
  福岡・九州大学医学部
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Novel compound which up-regulates secondary metabolite gene cluster2012
- Author(s)
  高橋俊二
- Organizer
  The International Conference of Natural Product Biosynthesis
- Place of Presentation
  Awaji Yumebutai, Hyogo
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] リベロマイシン生合成における3級水酸基のサクシニル化2012
- Author(s)
  高橋俊二
- Organizer
  第27回放線菌学会
- Place of Presentation
  東京・府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] 放線菌二次代謝産物の生合成2012
- Author(s)
  高橋俊二
- Organizer
  第3回生合成マシナリー札幌セミナー
- Place of Presentation
  札幌・北海道大学(招待講演)
- Year and Date
  2012-07-23
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Novel compound which up-regulates secondary metabolite gene cluster2012
- Author(s)
  高橋俊二
- Organizer
  The International Conference of Natural Product Biosynthesis
- Place of Presentation
  Awaji Yumebutai, Hyogo
- Invited
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] リベロマイシン生合成における3級水酸基のサクシニル化2012
- Author(s)
  高橋俊二
- Organizer
  放線菌学会
- Place of Presentation
  府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] サクシニル化に関わるリベロマイシン生合成遺伝子の機能解析2012
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  京都・京都女子大
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] サクシニル化に関わるリベロマイシン生合成遺伝子の機能解析2012
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Structure and Function of P450revI in Reveromycin A Biosynthesis2012
- Author(s)
  Takahashi S.
- Organizer
  チトクロムP450発見50周年記念シンポジウム
- Place of Presentation
  九州大学
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Structure and Function of P450revI in Reveromycin A Biosynthesis2012
- Author(s)
  高橋俊二
- Organizer
  チトクロムP450発見50周年記念シンポジウム
- Place of Presentation
  福岡・九州大学医学部
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] リベロマイシン生合成における3級水酸基のサクシニル化2012
- Author(s)
  高橋　俊二
- Organizer
  第27回　放線菌学会
- Place of Presentation
  東京・府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Deciphering of reveromycin A biosynthesis2012
- Author(s)
  Takahashi S.
- Organizer
  RIKEN-MAXPLANCK JOINT RESEARCH CENTER Kick Off Symposium
- Place of Presentation
  Dortmund, Germany
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Novel compound which up-regulates secondary metabolite gene cluster2012
- Author(s)
  Takahashi S.
- Organizer
  The International Conference of Natural Product Biosynthesis
- Place of Presentation
  Awaji Yumebutai
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] Deciphering of reveromycin A biosynthesis and the production of novel derivatives2011
- Author(s)
  Shunji Takahashi
- Organizer
  International union of microbiological societies.(IUMS),放線菌学会共催
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] 遺伝子破壊によるリベロマイシン生合成機構の解析2011
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Mechanism of 2-alkylmalonyl-CoA formation in reveromycin A biosynthesis2011
- Author(s)
 Shunji Takahashi
- Organizer
 16^<th> International Symposium on the Biology of Actinomycetes
- Place of Presentation
 Puerto Vallarta, Mexico
- Data Source
 KAKENHI-PROJECT-21580104
[Presentation] 遺伝子破壊によるリベロマイシン生合成機構の解析2011
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  京都・京都女子大
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Identification of key enzymes involved in spiroacetal formation in reveromycin A biosynthesis2011
- Author(s)
  高橋俊二
- Organizer
  IUMS (International union of microbiological societies)
- Place of Presentation
  札幌・札幌コンベンションセンター(招待講演)
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Identification of key enzymes involved in spiroacetal formation in reveromycin A biosynthesis2011
- Author(s)
  Shunji Takahashi
- Organizer
  International union of microbiological societies(IUMS),放線菌学会共催
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Identification of key enzymes involved in spiroacetal formation in reveromycin A biosynthesis2011
- Author(s)
  高橋俊二
- Organizer
  IUMS(International union of microbiological societies)放線菌学会共催
- Place of Presentation
  札幌・札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイシンAスピロケタール生成に関わる新規デヒドロゲナーゼの機能解析2010
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  東京、東京大学
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイニンAスピロケタール生成に関わる新規デヒドロゲナーゼの機能解析2010
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  東京大学駒場
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイシンAスピロケタール生成に関わる新規デヒドロゲナーゼの機能解析2010
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京大学駒場キャンパス(東京)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] リベロマイシンAのスピロアセタール環化機構の解析2010
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Place of Presentation
  タワーホール船堀(東京)
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイシンAのスピロアセタール環化機構の解析2010
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Place of Presentation
  東京・タワーホール船堀
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Analysis of Reveromycin A Biosynthetic Gene Cluster2010
- Author(s)
  高橋俊二
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国・ハワイ・コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Pathway Engineering of a Polyketide Compound, Reveromycin A.2010
- Author(s)
  高橋俊二
- Organizer
  The 5th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] リベロマイシンA生合成遺伝子クラスターの機能解析2009
- Author(s)
  高橋俊二
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイシンAのスピロケタール生合成機構の解析2009
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Place of Presentation
  秋田ビューホテル
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Biochemical and crystal structure analyses of reveromycin E hydroxylase(P450RME)in reveromycin A biosynthetic gene cluster2009
- Author(s)
  高橋俊二
- Organizer
  15th International Symposium on the Biology of Actinomycetes
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] リベロマイシンA生合成遺伝子P450RMEの機能解析2009
- Author(s)
  高橋俊二, 他
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Biochemical and crystal structure analyses of revenomycine E hydroxylase(P450RME)in reveromycin A biosynthetic gene cluster2009
- Author(s)
  高橋俊二
- Organizer
  15th International Symposium on the Biology of Actinomycetes(ISBA'15)
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイシンAのスピロケタール生合成機構の解析2009
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Place of Presentation
  秋田市、秋田ビューホテル
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] リベロマイシンAのスピロケタール生合成機構の解析2009
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会2009年度大会
- Place of Presentation
  秋田ビューホテル(秋田)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Biochemical and crystal structure analyses of revenomycine E hydroxylase(P450RME) in reveromycin A biosynthetic gene cluster2009
- Author(s)
  Shunji Takahashi
- Organizer
  15th International Symposium on the Biology of Actinomycetes(ISBA' 15)
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Analysis of Reveromycin A Biosynthetic Gene Cluste2009
- Author(s)
  Shunji Takahashi
- Organizer
  International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Prenyltransferase from Streptomyces reveromyceticus2009
- Author(s)
  Shunji Takahashi
- Organizer
  TERPNET2009
- Place of Presentation
  University of Tokyo
- Data Source
  KAKENHI-PROJECT-21580104
[Presentation] Prenyltransferase from Streptomyces reveromyceticus2009
- Author(s)
  高橋俊二
- Organizer
  TERPNET2009
- Place of Presentation
  東京大学(東京)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Streptomyces reveromyceticus由来インドールプレニルトフンスノェフーゼの機能解析2008
- Author(s)
  高橋俊二, 他
- Organizer
  2008年日本放線菌学会大会
- Place of Presentation
  フルーツパーク富士屋ホテル(山梨)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Analysis of reveromycin A biosynthetic gene cluster2007
- Author(s)
  Shunji Takahashi
- Organizer
  The society for Actinomycetes Japan
- Place of Presentation
  Hiroshima(Simanami Koryukan)
- Year and Date
  2007-05-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580085
[Presentation] リベロマイシンA生合成遺伝子クラスターの解析2007
- Author(s)
  高橋俊二
- Organizer
  日本農芸化学会
- Place of Presentation
  東京農業大学
- Year and Date
  2007-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580085
[Presentation] Analysis of reveromycin A biosynthetic gene cluster in Streptomyces reveromyceticus2007
- Author(s)
  Takahashi S., et. al.
- Organizer
  The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
- Place of Presentation
  Sheraton Miyako Hotel Tokyo
- Year and Date
  2007-12-03
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] リベロマイシンA生合成遺伝子クラスターの解析2007
- Author(s)
  高橋俊二
- Organizer
  日本放線菌学会
- Place of Presentation
  広島(尾道しまなみ交流館)
- Year and Date
  2007-05-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580085
[Presentation] リベロマイシンA生合成遺伝子クラスターの解析2007
- Author(s)
  高橋俊二, 他
- Organizer
  2007年度日本放線菌学会大会
- Place of Presentation
  しまなみ交流館(尾道)
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Analysis of reveromycin A biosynthetic gene cluster2007
- Author(s)
  Shunji Takahashi
- Organizer
  Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Place of Presentation
  Tokyo Univerisity of Agriculture
- Year and Date
  2007-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580085
[Presentation] 経路特異的転写因子を活用したテルペノイド生合成遺伝子群の一括発現と有用物質生産
- Author(s)
  高橋俊二
- Organizer
  新学術領域「生合成マシーナリー」第７回公開シンポジウム
- Place of Presentation
  東京工業大学
- Year and Date
  2014-06-21 – 2014-06-22
- Data Source
  KAKENHI-PUBLICLY-25108726
[Presentation] In vitro reconstitution of biosynthetic machinery for reveromycin
- Author(s)
  Hiroyuki Osada and Shunji Takahashi
- Organizer
  XVII. International Symposium on the Biology of Actinomycetes
- Place of Presentation
  Pine Bay Holiday Resort Hotel, Turkey
- Year and Date
  2014-10-08 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] 第３回生合成マシナリー札幌セミナー
- Author(s)
  高橋　俊二
- Organizer
  放線菌二次代謝産物の生合成
- Place of Presentation
  札幌・北海道大学
- Invited
- Data Source
  KAKENHI-PROJECT-24658088
[Presentation] 3級水酸基のサクシニル化反応に見出されるRevLのフマル化修飾
- Author(s)
  前島希、高橋俊二、宮澤岳、鈴木健裕、堂前直、円谷陽一、長田裕之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Engineering of primary metabolism in Streptomyces reveromyceticus
- Author(s)
  Suresh Panthee, Shunji Takahashi, Tomokazu Shirai, Akihiko Kondo, Hiroyuki Osada
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Isolation of new cyclic depsipeptides from a microbial metabolites fraction library by NPPlot screening
- Author(s)
  Jang Jun-Pil, Toshihiko Nogawa, Yayoi Hongo, Takeshi Shimizu, Akiko Okano, Yushi Futamura, Shunji Takahashi, Jong Seong Ahn, Hiroyuki Osada
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] アルコール添加による新規リベロマイシン誘導体の創製と生合成機構の考察
- Author(s)
  野川俊彦、高橋俊二、高木海、関山恭代、岡野亜紀子、川谷誠、清水猛、長田裕之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] 異種発現によるtautomycin生合成遺伝子クラスターの解析
- Author(s)
  寺井淳高, 高橋俊二, 橋本絢子, 新家一男, 池田治生, 川崎寿, 長田裕之
- Organizer
  第29回　放線菌学会
- Place of Presentation
  つくばカピオ
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Characterization of BR-1 activity on LAL family regulator in reveromycin biosynthesis
- Author(s)
  Suresh Panthee, Shunji Takahashi, Seiji Matsuoka, Tetsuo Onuki, Minoru Yoshida, Hiroyuki Osada
- Organizer
  第29回　放線菌学会
- Place of Presentation
  つくばカピオ
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Engineering of primary metabolism in Streptomyces reveromyceticus
- Author(s)
  Suresh Panthee, Shunji Takahashi, Tomokazu Shirai, Akihiko Kondo, Hiroyuki Osada
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PUBLICLY-25108726
[Presentation] テロメスタチン生合成遺伝子クラスターの異種発現
- Author(s)
  天貝啓太, 柴崎典子, 高木海, 工藤史貴, 江口正, 長田裕之, 池田治生, 新家一男,　高橋俊二
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] 遺伝子ターゲティングによる糸状菌二次代謝産物生合成経路の全容解明
- Author(s)
  加藤直樹，高橋俊二，長田裕之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Upregulation of secondary metabolite gene cluster by exogenous small molecule
- Author(s)
  Shunji Takahashi, Suresh Panthee, and Hiroyuki Osada
- Organizer
  XVII. International Symposium on the Biology of Actinomycetes
- Place of Presentation
  Pine Bay Holiday Resort Hotel, Turkey
- Year and Date
  2014-10-08 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] マメ科植物クララSophora flavescensのLC/MSを用いたメタボロミクスによる産地比較
- Author(s)
  長田麻由佳、野川俊彦、鈴木龍一郎、高橋俊二、白瀧義明、長田裕之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] Butylmalonyl-CoAの選択的生産に関与するRevRの機能解析
- Author(s)
  宮澤岳、高橋俊二、鈴木健裕、堂前直、長田裕之
- Organizer
  第29回　放線菌学会
- Place of Presentation
  つくばカピオ
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24380052
[Presentation] 経路特異的転写因子を活用したテルペノイド生合成遺伝子群の一括発現と有用物質生産
- Author(s)
  高橋俊二
- Organizer
  新学術領域「生合成マシーナリー」第8回公開シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PUBLICLY-25108726

1. OKUMURA Hideo (90377903)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. KITA Kazuko (80302545)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OSADA Hiroyuki (80160836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 49 results
4. YOSHIDA Minoru (80191617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NOMURA Jun (30252886)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SUZUKI Nobuo (90111426)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 加藤直樹 (90442946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
8. 鄭宇 (50894432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. 滝田良 (50452321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. SAITO Akiko (40415162)

# of Collaborated Projects: 1 results

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11. SHIMIZU Takeshi (80087569)

# of Collaborated Projects: 1 results

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12. SHIRO Yoshitsugu (70183051)

# of Collaborated Projects: 1 results

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13. KAKEYA Hideaki (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. USUI Takeo (60281648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HAYASHI Yujiro (00198863)

# of Collaborated Projects: 1 results

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16. KOJIMA Soichi (10202061)

# of Collaborated Projects: 1 results

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17. SUGAYA Shigeru (90334177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. FUTAMURA Yushi (70525857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
19. 山森秀夫 (00166836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高木一也 (80251164)

# of Collaborated Projects: 1 results

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21. 坂井克行 (80894568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
22. Vo NgocQuynhNhu (60888543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
23. 野川俊彦 (40462717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
24. 永野真吾 (60286440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
25. KANOH Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 臼井健朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 中村健道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 本山高幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 廣田洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 熊倉直祐

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# of Collaborated Products: 1 results
31. 橋本拓哉

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# of Collaborated Products: 1 results
32. 内山真伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 阿部郁朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 室井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 池田治生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Shunji 高橋 俊二

TAKAHASHL Shunji 高橋 俊二

Research Projects

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Complex multi-enzyme reactions and unexplored substrate channeling mechanisms in secondary metabolite biosynthesisPrincipal Investigator

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Elucidation of the molecular basis of biosynthesis that confers bioactivity to natural compounds and de novo design of novel enzymesPrincipal Investigator

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銅受容機構の恒常性の攪乱による二次代謝生合成遺伝子の活性化機構の解明Principal Investigator

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AI-based functional elucidation of unknown secondary metabolic biosynthetic enzymes and precise analysis of molecular interactionsPrincipal Investigator

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Establishment of platform for creation of novel bioactive natural products by expression of latent functions of microorganismsPrincipal Investigator

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Enhanced production of natural compounds using the potential chemical signal response mechanisms of micro-organismsPrincipal Investigator

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Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural productsPrincipal Investigator

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Construction of biosynthetic platform based on metabolism logic of actinomycete and elucidation of the function of unknown biosynthetic genePrincipal Investigator

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Construction of terpenoid producing platform in Actinomycetes and creation of novel secondary metabolitesPrincipal Investigator

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Modification of polyketide synthase and elucidation of enzyme reaction which is difficult in chemical synthesis, and creation of novel natural productsPrincipal Investigator

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Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genes

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経路特異的転写因子を活用したテルペノイド生合成遺伝子群の一括発現と有用物質生産Principal Investigator

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Construction of a biosynthetic logic toward a new era of natural productPrincipal Investigator

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TAKAHASHI Shunji 高橋俊二

TAKAHASHL Shunji 高橋俊二

[Book] リベロマイシンＡ生合成にかかわる未知酵素の解明　スピロアセタール環化酵素の発見2013