Nagai Kenichirou 長井賢一郎

… Alternative Names

Nagai Kenichiro 長井賢一郎

NAGAI KENICHIROU 長井賢一郎

NAGAI Kenichiro 長井賢一郎

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Researcher Number	30321649
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 北里大学, 薬学部, 講師 2021 – 2023: 北里大学, 薬学部, 講師 2019 – 2020: 北里大学, 薬学部, 助教 2014 – 2017: 北里大学, 薬学部, 助教 2008 – 2012: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Chemical biology / Drug development chemistry
Keywords	Principal Investigator ペプチド / アムホテリシンB活性増強作用 / ネクトリアチド / アムホテリシンB / ネクトリアタイド / 活性増強作用 / 鎖状ペプチド / ペプチド合成 / 活性増強 / 環状ペプチド … More / 抗結核剤 / カルピナクタム / 固相合成 / 天然物 / 抗結核薬 … More Except Principal Investigator ケミカルバイオロジー / 肺 MAC 症 / 肺MAC症 / 真菌症 / MAC症 / 結核症 / MRSA / 抗感染症剤 / ゲノム編集 / CRISPR/Cas9 / 創薬 / ウロキナーゼ / RSK / マルホルミン / 線溶系 / 抗血栓薬 / 微生物二次代謝産物 / 血栓溶解 Less

アムホテリシンB活性増強作用を持つ天然由来のペプチドを基盤とした創薬研究Principal Investigator
- Principal Investigator
  
  長井賢一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kitasato University
Study on naturally-occurring peptides potentiating amphotericin B activityPrincipal Investigator
- Principal Investigator
  
  長井賢一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kitasato University
Study on cyclic peptides with amphotericin B potentiating activityPrincipal Investigator
- Principal Investigator
  
  Nagai Kenichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kitasato University
Discovery of new anti-infectives based on chemical biology
- Principal Investigator
  
  Koyama Nobuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Analysis of molecular targets and development into drug discovery for cyclic peptides possessing thrombolysis-enhancing action
- Principal Investigator
  
  KOIZUMI Yukio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Akita University
Development of anti-tuberculosis drugs based on calpinactamPrincipal Investigator
- Principal Investigator
  
  NAGAI Kenichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Chemical biology aimed at the development of new thrombolytics
- Principal Investigator
  
  KOIZUMI Yukio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Drug development chemistry
- Research Institution
  Akita University

All 2024 2023 2022 2021 2020 2019 2016 2014 2012 2011

All Journal Article Presentation

[Journal Article] Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity2024
- Author(s)
  Nagai, K.; Kobayashi, K.; Miyake, R.; Sato, Y.; Seki, R.; Fukuda, T.; Yagi, A.; Uchida, R.; Ohshiro, T.; Tomoda, H
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 4 Pages: 214-220
- DOI
  10.1038/s41429-023-00700-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05333, KAKENHI-PROJECT-21K15284
[Journal Article] Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-01142019
- Author(s)
  Takashi Fukuda, Kenichiro Nagai, Akiho Yagi, Keisuke Kobayashi, Ryuji Uchida, Tadashi Yasuhara, and Hiroshi Tomoda
- Journal Title
  
  JOURNAL OF NATURAL PRODUCTS
  
  Volume: 82 Issue: 10 Pages: 2673-2681
- DOI
  10.1021/acs.jnatprod.8b01056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05719
[Journal Article] Structure-activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers.2016
- Author(s)
  Koizumi Y, Nagai K, Hasumi K, Kuba K, Sugiyama T
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 21 Pages: 5267-5271
- DOI
  10.1016/j.bmcl.2016.09.045
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293050, KAKENHI-PROJECT-26350969, KAKENHI-PROJECT-15K15304
[Journal Article] Mangromicins A and B: Structure and Anti-trypanosomal Activity of two new Cyclopentadecane Compounds from Lechevalieria aerocolonigenes K10-02162014
- Author(s)
  Nakashima T, Iwatsuki M, Ochiai J, Kamiya Y, Nagai K, Matsumoto A, Ishiyama A, Otoguro K, Shiomi K, Takahashi Y, Omura S
- Journal Title
  
  J Antibiot
  
  Volume: 67 Issue: 3 Pages: 253-260
- DOI
  10.1038/ja.2013.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350969
[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012
- Author(s)
  Kenichiro Nagai, Nobuhiro Koyama, Noriko Sato, Chisato Yanagisawa, Hiroshi Tomoda
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 7739-7741
- URL
  http://dx.doi.org/10.1016/j.bmcl.2012.09.069
- Data Source
  KAKENHI-PROJECT-23790019
[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012
- Author(s)
  Kenichiro Nagai
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 24 Pages: 7739-7741
- DOI
  10.1016/j.bmcl.2012.09.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790019, KAKENHI-PROJECT-23790020
[Presentation] Amphotericin B 活性増強物質 nectriatide 誘導体の合成と活性評価2023
- Author(s)
  長井賢一郎、小林啓介、三宅良介、佐藤雪乃、関怜子、福田隆志2、八木瑛穂、内田龍児、大城太一、供田洋
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K05333
[Presentation] なぜ nectriatide は抗真菌剤 amphotericin B の活性を増強するのか？2022
- Author(s)
  三宅良介、小林啓介、長井賢一郎、西村慎一、供田洋、大城太一
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-22K05333
[Presentation] カイコを用いた抗真菌剤 amphotericin B 活性増強化合物 nectriatide の簡易 in vivo 評価2021
- Author(s)
  三宅良介,小林啓介,長井賢一郎,大城太一,供田洋
- Organizer
  日本薬学会142年会
- Data Source
  KAKENHI-PROJECT-19K05719
[Presentation] 抗真菌剤amphotericin B活性増強作用を示す真菌由来nectriatideに関する研究2020
- Author(s)
  三宅　良介、長井賢一郎、小林啓介、供田洋
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K05719
[Presentation] 真菌由来 nectriatide の合成中間体が示す抗真菌剤 amphotericin B 活性増強作用2019
- Author(s)
  佐藤雪乃、長井賢一郎、小林啓介、福田隆志、供田洋
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K05719
[Presentation] 血栓溶解を促進するマルホルミンの構造活性相関2011
- Author(s)
  小泉幸央、長井賢一郎、蓮見恵司、小代田宗一、杉山俊博
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-20200037
[Presentation] 血栓溶解を促進するマルホルミンの構造活性相関2011
- Author(s)
  小泉幸央、長井賢一郎、蓮見惠司、小代田宗一、杉山俊博
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  京都
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-20200037

1. KOIZUMI Yukio (80353465)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. KOYAMA Nobuhiro (60439156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SATO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KUBA Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagai Kenichirou 長井 賢一郎

Nagai Kenichiro 長井 賢一郎

NAGAI KENICHIROU 長井 賢一郎

NAGAI Kenichiro 長井 賢一郎

Research Projects

Research Products

Co-Researchers

アムホテリシンB活性増強作用を持つ天然由来のペプチドを基盤とした創薬研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on naturally-occurring peptides potentiating amphotericin B activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on cyclic peptides with amphotericin B potentiating activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of new anti-infectives based on chemical biology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular targets and development into drug discovery for cyclic peptides possessing thrombolysis-enhancing action

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of anti-tuberculosis drugs based on calpinactamPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical biology aimed at the development of new thrombolytics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-01142019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mangromicins A and B: Structure and Anti-trypanosomal Activity of two new Cyclopentadecane Compounds from Lechevalieria aerocolonigenes K10-02162014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012

Author(s)

Journal Title

URL

Data Source

[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Amphotericin B 活性増強物質 nectriatide 誘導体の合成と活性評価2023

Nagai Kenichirou 長井賢一郎

Nagai Kenichiro 長井賢一郎

NAGAI KENICHIROU 長井賢一郎

NAGAI Kenichiro 長井賢一郎