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Higashimoto Ken  東元 健

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HIGASHIMOTO Ken  東元 健

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Researcher Number 30346887
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2020 – 2023: 佐賀大学, 医学部, 准教授
2018: 佐賀大学, 医学部, 講師 (特定)
2013 – 2017: 佐賀大学, 医学部, 助教
2009 – 2011: Saga University, 医学部, 助教
2005: 佐賀大, 医学部, 助手
2004 – 2005: 佐賀大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Human genetics / Pathological medical chemistry
Except Principal Investigator
Human genetics
Keywords
Principal Investigator
Sotos症候群 / モデルマウス / NSD1 / Nsd1 / DNAメチル化 / ヒストンH3リジン36メチル化酵素 / 海馬成熟神経 / エピジェネティクス / 知的障害 / 学習障害モデルマウス … More / 学習障害 / DMR / 刷り込み遺伝子 / Beckwith-Wiedemann症候群 / 発生・分化 / 細胞・組織 / インプリンティングセンター / ES細胞 / ピストン化学修飾 / インプリンティング遺伝子 … More
Except Principal Investigator
ゲノム刷り込み / Wilms tumor / cancer / Beckwith-Wiedemann syndrome / Histone methylation / DNA methylation / Genomic imprinting / ヒストンH3K27トリメチル化 / ヒストンH3K9メチル化 / Wilms腫瘍 / 癌 / Beckwith-Wiedemann症候群 / ヒストンメチル化 / DNAメチル化 / LIT1刷り込みドメイン / KIP2 / siRNAライブラリー / non-coding RNA / 刷り込みドメイン / エピジェネティクス Less
  • Research Projects

    (8 results)
  • Research Products

    (96 results)
  • Co-Researchers

    (23 People)
  •  独自に樹立したSotos症候群モデルマウスを用いた知的障害発症機構の解明Principal Investigator

    • Principal Investigator
      東元 健
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Saga University
  •  Establishment of Sotos syndrome model mice with intellectual disability and elucidation of the onset mechanismPrincipal Investigator

    • Principal Investigator
      Higashimoto Ken
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Saga University
  •  Establishment of the model mouse and elucidation of the onset mechanism for development of therapeutic basis in Sotos syndromePrincipal Investigator

    • Principal Investigator
      Higashimoto Ken
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Saga University
  •  Aberrant DNA methylation at imprinting control regions in Sotos syndromePrincipal Investigator

    • Principal Investigator
      Higashimoto Ken
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Saga University
  •  The regulation of bone formation by epigenetic factor MeCP2Principal Investigator

    • Principal Investigator
      HIGASHIMOTO Ken
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Human genetics
    • Research Institution
      Saga University
  •  Identification of regulatory factors for genomic imprinting using siRNA library

    • Principal Investigator
      SOEJIMA Hidenobu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Saga University
  •  ヒト疾患関連刷り込み遺伝子におけるヒストン化学修飾の役割Principal Investigator

    • Principal Investigator
      東元 健
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Saga University
  •  A molecular base of epigenetic gene expression control in imprinted domain

    • Principal Investigator
      SOEJIMA Hidenobu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Saga University

All 2023 2022 2021 2020 2018 2016 2015 2014 2013 2011 2010 2009 2008 2006 Other

All Journal Article Presentation Book

  • [Book] 別冊日本臨牀 新領域別症候群シリーズNo.29 神経症候群(第2版)Ⅳ–その他の神経疾患を含めて–2014

    • Author(s)
      東元健、副島英伸
    • Total Pages
      4
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Book] 遺伝子医学MOOK25 第2章エピジェネティクスと病気 4.不妊・先天異常2013

    • Author(s)
      東元健、副島英伸
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Book] Beckwith-Wiedemann症候群、小児科・小児疾患における臨床遺伝学の進歩2009

    • Author(s)
      東元健、副島英伸
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] Donor cord blood aging accelerates in recipients after transplantation2023

    • Author(s)
      Onizuka Makoto、Imanishi Tadashi、Harada Kaito、Aoyama Yasuyuki、Amaki Jun、Toyosaki Masako、Machida Shinichiro、Kikkawa Eri、Yamada Sanetoshi、Nakabayashi Kazuhiko、Hata Kenichiro、Higashimoto Ken、Soejima Hidenobu、Ando Kiyoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 2603-2603

    • DOI

      10.1038/s41598-023-29912-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451, KAKENHI-PROJECT-23K24490
  • [Journal Article] Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells.2023

    • Author(s)
      Yurie Yamamoto, Ken Higashimoto, Yuki Ohkawa, Hidenobu Soejima, Kei Kaneko, Yuhsuke Ohmi, Keiko Furukawa, Koichi Furukawa
    • Journal Title

      Glycoconj. J

      Volume: 40 Issue: 3 Pages: 1-10

    • DOI

      10.1007/s10719-023-10108-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06828, KAKENHI-PROJECT-20K07629, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451, KAKENHI-PROJECT-21K15493, KAKENHI-PROJECT-23K06420, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-19K07393
  • [Journal Article] Placental Mesenchymal Dysplasia and Beckwith?Wiedemann Syndrome2022

    • Author(s)
      Soejima Hidenobu、Hara Satoshi、Ohba Takashi、Higashimoto Ken
    • Journal Title

      Cancers

      Volume: 14 Issue: 22 Pages: 5563-5563

    • DOI

      10.3390/cancers14225563

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451
  • [Journal Article] Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia2022

    • Author(s)
      Aoki Saori、Higashimoto Ken、Hidaka Hidenori、Ohtsuka Yasufumi、Aoki Shigehisa、Mishima Hiroyuki、Yoshiura Koh-ichiro、Nakabayashi Kazuhiko、Hata Kenichiro、Yatsuki Hitomi、Hara Satoshi、Ohba Takashi、Katabuchi Hidetaka、Soejima Hidenobu
    • Journal Title

      Clinical Epigenetics

      Volume: 14 Issue: 1 Pages: 64-64

    • DOI

      10.1186/s13148-022-01280-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451, KAKENHI-PROJECT-23K24490
  • [Journal Article] DNA Methylation Analysis Using Bisulfite Pyrosequencing2022

    • Author(s)
      Higashimoto Ken、Hara Satoshi、Soejima Hidenobu
    • Journal Title

      Methods Mol Bio

      Volume: - Pages: 3-20

    • DOI

      10.1007/978-1-0716-2724-2_1

    • ISBN
      9781071627235, 9781071627242
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Journal Article] TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.2021

    • Author(s)
      Mori H, Takahashi H, Mine K, Higashimoto K, Inoue K, Kojima M, Kuroki S, Eguchi T, Ono Y, Inuzuka S, Soejima H, Nagafuchi S, Anzai K.
    • Journal Title

      Genes (Basel).

      Volume: 12 Issue: 3 Pages: 400-400

    • DOI

      10.3390/genes12030400

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-18H02853, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-21K19451
  • [Journal Article] Clinical manifestations of placental mesenchymal dysplasia in Japan: A multicenter case series.2021

    • Author(s)
      Kodera C, Aoki S, Ohba T, Higashimoto K, Mikami Y, Fukunaga M, Soejima H, Katabuchi H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 47 Issue: 3 Pages: 1118-1125

    • DOI

      10.1111/jog.14647

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-21K19451
  • [Journal Article] Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith?Wiedemann syndrome2021

    • Author(s)
      Sun Feifei、Hara Satoshi、Tomita Chiyoko、Tanoue Yuka、Yatsuki Hitomi、Higashimoto Ken、Soejima Hidenobu
    • Journal Title

      American Journal of Medical Genetics Part A

      Volume: 185 Issue: 10 Pages: 3062-3067

    • DOI

      10.1002/ajmg.a.62364

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06451, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451
  • [Journal Article] Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome.2020

    • Author(s)
      Higashimoto K, Watanabe H, Tanoue Y, Tonoki H, Tokutomi T, Hara S, Yatsuki H, Soejima H.
    • Journal Title

      J Med Genet.

      Volume: - Issue: 6 Pages: 422-425

    • DOI

      10.1136/jmedgenet-2020-106907

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-21K19451
  • [Journal Article] Growing oocyte specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR2018

    • Author(s)
      Joh, K., Matsuhisa, F., Kitajima, S., Nishioka, K., Higashimoto, K., Yatsuki, H., Kono, T., Koseki, H., Soejima, H.
    • Journal Title

      Epigenetics & Chromatin

      Volume: 11 Issue: 1 Pages: 28-28

    • DOI

      10.1186/s13072-018-0200-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07138, KAKENHI-PROJECT-17K08687, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K09970, KAKENHI-PROJECT-18H00338
  • [Journal Article] Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer.2018

    • Author(s)
      Hidaka H, Higashimoto K, Aoki S, Mishima H, Hayashida C, Maeda T, Koga Y, Yatsuki H, Joh K, Noshiro H, Iwakiri R, Kawaguchi A, Yoshiura KI, Fujimoto K, Soejima H.
    • Journal Title

      Clin Epigenetics

      Volume: 10 Issue: 1 Pages: 150-150

    • DOI

      10.1186/s13148-018-0578-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-17K08687, KAKENHI-PROJECT-18K07850, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-16K09970, KAKENHI-PROJECT-18H00338
  • [Journal Article] The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.2016

    • Author(s)
      Rumbajan JM, Yamaguchi Y, Nakabayashi K, Higashimoto K, Yatsuki H, Nishioka K, Matsuoka K, Aoki S, Toda S, Takeda S, Seki H, Hatada I, Hata K, Soejima H, Joh K.
    • Journal Title

      Gene.

      Volume: 583 Issue: 2 Pages: 141-146

    • DOI

      10.1016/j.gene.2016.02.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461554, KAKENHI-PROJECT-26670169
  • [Journal Article] Beckwith-Wiedemann syndrome2015

    • Author(s)
      東元健、副島英伸
    • Journal Title

      日本臨床 家族性腫瘍学 家族性腫瘍の最新研究動向

      Volume: 73(増刊号6) Pages: 59-63

    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome.2015

    • Author(s)
      Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H.
    • Journal Title

      Clinical Genetics

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole.2015

    • Author(s)
      Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K,Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K
    • Journal Title

      Gynecol Obstet Invest.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] Beckwith-Wiedemann 症候群(BWS)2015

    • Author(s)
      東元健、副島英伸
    • Journal Title

      臨床画像

      Volume: 31(10増刊号) Pages: 189-191

    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] Fibroadenoma in a Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5.2014

    • Author(s)
      Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
    • Journal Title

      Pediatrics International

      Volume: 56 Issue: 6 Pages: 931-934

    • DOI

      10.1111/ped.12406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461554, KAKENHI-PROJECT-26670169
  • [Journal Article] Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations2014

    • Author(s)
      Maeda T, Higashimoto K, Jozaki K, Hitomi H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H
    • Journal Title

      Genet Med

      Volume: 16(12) Issue: 12 Pages: 903-912

    • DOI

      10.1038/gim.2014.46

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22132004, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-25253023, KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-25461554, KAKENHI-PROJECT-25461648, KAKENHI-PROJECT-25860898, KAKENHI-PROJECT-26670169
  • [Journal Article] Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome.2013

    • Author(s)
      Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H.
    • Journal Title

      Genes Genom.

      Volume: 35 Issue: 2 Pages: 141-147

    • DOI

      10.1007/s13258-013-0079-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] A novel de novo point mutation of OCT-binding site in the IGF2/H19-imprinting control region in a patient with Beckwith-Wiedemann syndrome.2013

    • Author(s)
      Higashimoto K, Jozaki K, Kosho T, Matsubara K, Sato T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, SoejimaH*
    • Journal Title

      Clin Genet

      Volume: in press Issue: 6 Pages: 539-544

    • DOI

      10.1111/cge.12318

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22132004, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-25253023, KAKENHI-PROJECT-25461554, KAKENHI-PROJECT-25461648, KAKENHI-PROJECT-25860898, KAKENHI-PROJECT-26670169
  • [Journal Article] Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-is in a Japanese patient with Perlman syndrome.2013

    • Author(s)
      Higashimoto, K, Maeda, T, Okada, J, Ohtsuka, Y, Sasaki, K, Hirose, A, Nomiyama, M, Takayanagi, T, Fukuzawa, R, Yatsuki, H, Koide, K, Nishioka, K, Joh, K, Watanabe, Y, Yoshiura, ICI, Soejima, H.
    • Journal Title

      European Journal of Human Genetics

      Volume: 21 Issue: 11 Pages: 1316-1319

    • DOI

      10.1038/ejhg.2013.45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J11173, KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-25461554
  • [Journal Article] Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome.2013

    • Author(s)
      Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H.
    • Journal Title

      Endocr J.

      Volume: 60 Pages: 403-408

    • NAID

      10031170628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing2013

    • Author(s)
      H. Miyazaki, K. Higashimoto, Y. Yada, T. A. Endo, J. Sharif, T. Komori, M. Matsuda, Y. Koseki, M. Nakayama, H. Soejima, H. Handa, H. Koseki, S. Hirose, K. Nishioka
    • Journal Title

      PLoS Genet.

      Volume: 9 Issue: 11 Pages: e1003897-e1003897

    • DOI

      10.1371/journal.pgen.1003897

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23102002, KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-25461554
  • [Journal Article] Beckwith-Wiedemann症候群とSilver-Russell症候群2013

    • Author(s)
      前田寿幸、東元健、副島英伸
    • Journal Title

      小児科臨床

      Volume: 66 Pages: 1308-1314

    • Data Source
      KAKENHI-PROJECT-25461554
  • [Journal Article] Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma2013

    • Author(s)
      Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
    • Journal Title

      BMC Cancer

      Volume: 13 Issue: 1 Pages: 608-619

    • DOI

      10.1186/1471-2407-13-608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23256006, KAKENHI-PROJECT-23592631, KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-24592698, KAKENHI-PROJECT-25461554
  • [Journal Article] Epigenetic and genetic alterations of the imprinting disorder Beckwith-Wiedemann syndrome and related disorders.2013

    • Author(s)
      Soejima H, Higashimoto K.
    • Journal Title

      J Hum Genet

      Volume: 58 Issue: 7 Pages: 402-409

    • DOI

      10.1038/jhg.2013.51

    • NAID

      10031190033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-25461554
  • [Journal Article] Beckwith-Wiedemann syndrome with placental chorangioma due to H19-DMR hypermethylation : A Case Report2011

    • Author(s)
      Aoki A, Shiozaki A, Sameshima A, Higashimoto K, Soejima H, Saito S
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(12) Pages: 1872-1876

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells2011

    • Author(s)
      Al-Dhaheri M, Wu J, Skliris GP, Li J, Higashimoto K, Wang Y, White KP, Lambert P, Zhu Y, Murphy L, Xu W
    • Journal Title

      Cancer Res

      Volume: 71(6) Pages: 2118-2128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] Acute megakaryocytic leukemia(AMKL, FAB ; M7) with Beckwith-Wiedemann syndrome2010

    • Author(s)
      Yamamoto S, Toyama D, Yatsuki H, Higashimoto K, Soejima H, Isoyama K
    • Journal Title

      Pediatr Blood Cancer

      Volume: 55(4) Pages: 733-735

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] Beckwith-Wiedemann症候群2009

    • Author(s)
      東元健
    • Journal Title

      小児科・小児疾患における臨床遺伝学の進歩 20

      Pages: 1046-1052

    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] 小児秤特集小児疾患における臨床遺伝学の進歩2009

    • Author(s)
      東元健、副島英伸
    • Journal Title

      Beckwith-Wiedemann症候群 50(7)

      Pages: 1046-1052

    • Data Source
      KAKENHI-PROJECT-20590330
  • [Journal Article] Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele2009

    • Author(s)
      Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H
    • Journal Title

      J Biochem

      Volume: 146(6) Pages: 771-774

    • NAID

      10026305033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] 特集小児疾患における臨床遺伝学の進歩Beckwith-Wiedemann症候群2009

    • Author(s)
      東元健
    • Journal Title

      小児科 50

      Pages: 1046-1052

    • Data Source
      KAKENHI-PROJECT-20590330
  • [Journal Article] Antisense transcription occurs at the promoter of a mouse imprinted gene, Commdl, on the repressed paternal allele.2009

    • Author(s)
      Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H
    • Journal Title

      J Biochem 146(6)

      Pages: 771-774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Journal Article] MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products.2008

    • Author(s)
      Yakabe S, Soejima H, Higashimoto K, Joh K
    • Journal Title

      Genes Genet Syst 83(2)

      Pages: 199-208

    • NAID

      10024396087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Journal Article] ゲノム刷り込みとBeckwith-Wiedemann症候群2008

    • Author(s)
      東元健, 副島英伸
    • Journal Title

      日本小児血液学会雑誌 22(3)

      Pages: 139-143

    • NAID

      10029309180

    • Data Source
      KAKENHI-PROJECT-20590330
  • [Journal Article] ゲノム刷り込みとBeckwith-Wiedemann症候群2008

    • Author(s)
      東元 健
    • Journal Title

      日本小児血液学会雑誌 22

      Pages: 139-143

    • NAID

      10029309180

    • Data Source
      KAKENHI-PROJECT-20590330
  • [Journal Article] Imprinting disruption of the KIP2/LIT1 domain : the molecular mechanism causing Beckwith-Wiedemann syndrome and cancer.2006

    • Author(s)
      Higashimoto K
    • Journal Title

      Cytogenet Genome Res 113(1-4)

      Pages: 306-312

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590263
  • [Journal Article] Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome

    • Author(s)
      Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H
    • Journal Title

      Am J Med Genet Part A

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Journal Article] Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome

    • Author(s)
      Higashimoto Ken
    • Journal Title

      American Journal of Medical Genetics Part A

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Sotos症候群モデルマウスの樹立と表現型解析2023

    • Author(s)
      東元 健、高雄 啓三、松久 葉一、吉岡 芳親、村田 祐造、佐久本 孟寿、原 聡史、北嶋 修司、青木 茂久、吉浦 孝一郎、副島 英伸
    • Organizer
      第16回エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Presentation] Beckwith-Wiedemann症候群に合併した副腎性クッシング症候群の一例2021

    • Author(s)
      八木 弘子、佐藤 知彦、神尾 卓哉、東元 健、副島 英伸、照井 君典
    • Organizer
      第29回特定非営利活動法人東北内分泌研究会・第41回日本内分泌学会東北地方会
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Presentation] DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2-DMR0 as a DNA methylation-dependent, P0 promoter-specific enhancer.2021

    • Author(s)
      東元 健, 渡邊 英孝, 三宅 紀子, 森田 純代, 堀居 拓郎, 畑田 出穂, 松本 直通, 副島 英伸.
    • Organizer
      第14回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Presentation] 表現型は一致するがDNAメチル化状態が一致しないBeckwith-Wiedemann症候群双胎(二絨毛膜二羊膜)の1例2021

    • Author(s)
      原 聡史、孫 菲菲、富田 知世子、田上 由香、八木 ひとみ、東元 健、副島 英伸
    • Organizer
      第66回日本人類遺伝学会
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Presentation] Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith-Wiedemann syndrome.2021

    • Author(s)
      Soejima H, Sun F, Yatsuki H, Higashimoto K, Hara S
    • Organizer
      European Society of Human Genetics Conference, 2021 Virtual Conference.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Presentation] Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome2020

    • Author(s)
      東元 健, 渡邉 聖, 田上 由香, 外木 秀文, 德富 智明, 原 聡史, 八木 ひとみ, 副島 英伸
    • Organizer
      第65回日本人類遺伝学会
    • Data Source
      KAKENHI-PROJECT-20K08183
  • [Presentation] 間葉性異形成胎盤のゲノム・エピゲノム解析2015

    • Author(s)
      青木早織、東元健、樋高秀憲、渡邊英孝、大塚泰史、三嶋博之、吉浦孝一郎、八木ひとみ、西岡憲一、城圭一郎、大場隆、片渕秀隆、副島英伸.
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      京王プラザホテル 新宿
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 間葉性異形成胎盤の分子遺伝学的解析2015

    • Author(s)
      青木早織、東元健、樋高秀憲、渡邊英孝、大塚泰史、三嶋博之、吉浦孝一郎、八木ひとみ、西岡憲一、城圭一郎、大場隆、片渕秀隆、副島英伸.
    • Organizer
      第23回日本胎盤学会学術集会
    • Place of Presentation
      JA共済ビル カンファレンスホール 東京
    • Year and Date
      2015-11-05
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 大腸癌におけるインプリントDMRの包括的メチル化解析2015

    • Author(s)
      樋高秀憲、東元健、青木早織、渡邊英孝、八木ひとみ、西岡憲一、城圭一郎、前田寿幸、古賀靖大、岩切龍一、能城浩和、藤本一眞、副島英伸
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      京王プラザホテル 新宿
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Clinical and histopathlogical features of placental mesenchymal dysplasia.2015

    • Author(s)
      Aoki S, Ohba T, Okajima M, Higashimoto K, Soejima H, Katabuchi H.
    • Organizer
      The 6th Asan-Kumamoto Joint Symposium
    • Place of Presentation
      熊本地域医療センター新館
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Beckwith-Wiedemann症候群エピ変異症例におけるインプリントDMRの包括的メチル化解析2015

    • Author(s)
      前田寿幸、城崎幸介、八木ひとみ、東元 健、松尾宗明、副島英伸
    • Organizer
      第57回日本小児神経学会学術集会
    • Place of Presentation
      帝国ホテル 大阪
    • Year and Date
      2015-05-28
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Beckwith-Wiedemann症候群における新生児期低血糖合併機序の検討2015

    • Author(s)
      長嶋一昭、田中大祐、東元 健、八木ひとみ、杉崎 和、田原 裕美子、副島英伸、稲垣暢也
    • Organizer
      第112回日本内科学会総会
    • Place of Presentation
      みやこめっせ 京都
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Beckwith-Wiedemann症候群の原因となる片親性父性ダイソミーの切断点領域の解析2015

    • Author(s)
      大塚泰史、岡岳彦、川原弘三、八木ひとみ、東元健、副島英伸
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      京王プラザホテル 新宿
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] シスチン尿症を伴うゲノムワイド父性片親性ダイソミー症例の遺伝子解析2013

    • Author(s)
      大塚泰史、佐々木健作、城崎幸介、東元健、岡本信彦、高間勇一、窪田昭男、松本富美、中山雅弘、吉浦孝一郎、副島英伸
    • Organizer
      第48回日本小児腎臓病学会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 本邦における間葉性異形成胎盤の臨床像.2013

    • Author(s)
      青木早織、大場隆、岡島翠、坂口 勲、東元健、副島英伸、福永真治、片渕秀隆.
    • Organizer
      第21回日本胎盤学会学術集会
    • Place of Presentation
      愛知
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Practical use of pyrosequencing analysis to detect Moyamoya disease susceptible gene RNF213 variant c.14576G>A.2013

    • Author(s)
      Takamatsu Y, Maeda T, Matsuo M, Higashimoto K, Kawashima M, Matsushima T, Soejima H.
    • Organizer
      3rd International Moyamoya Meeting
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.2013

    • Author(s)
      宮崎仁美、東元 健、矢田有加里、遠藤高帆、Sharif Jafar、小森敏治, 、松田正史、古関庸子、中山学、副島英伸、半田宏、古関明彦、広瀬進、西岡憲一.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 間葉性異形成胎盤における11p15刷り込み領域の分子遺伝学的解析.2013

    • Author(s)
      副島英伸、東元健、城﨑幸介、八木ひとみ、大塚泰史、前田寿幸、青木早織、岡島翠、坂口勲、大場隆、片渕秀隆.
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      宮城
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 間葉性異形成胎盤における11p15インプリント領域の分子遺伝学的解析2013

    • Author(s)
      副島英伸、東元健、城﨑幸介、八木ひとみ、大塚泰史、前田寿幸、青木早織、岡島翠、坂口勲、大場隆、片渕秀隆
    • Organizer
      第21回日本胎盤学会学術集会
    • Place of Presentation
      愛知
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] シスチン尿症を伴うゲノムワイド父性片親性ダイソミー症例の遺伝子解析2013

    • Author(s)
      大塚泰史、佐々木健作、城崎幸介、東元健、岡本信彦、高間勇一、窪田昭男、松本富美、中山雅弘、吉浦孝一郎、副島英伸.
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      宮城
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Beckwith-Wiedemann症候群におけるインプリントDMRのマルチローカスメチル化解析2013

    • Author(s)
      前田寿幸、東元健、中林一彦、城崎幸介、八木ひとみ、緒方勤、秦健一郎、副島英伸
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] H19DMRメチル化異常で発症するインプリント疾患におけるH19DMRの変異解析2013

    • Author(s)
      東元 健、城崎幸介、八木ひとみ、古庄知己、松原圭子、山田大輔、前田寿幸、大塚泰史、古関明彦、緒方勤、副島英伸
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 胎児発育異常症例の網羅的ゲノム・エピゲノム解析2013

    • Author(s)
      佐々木かりん、右田王介、中林一彦、東元健、前田寿幸、橋本和法、松井英雄、副島英伸、高田史男、秦健一郎.
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      宮城
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析. 180超例の解析により明らかとなった本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム変異2011

    • Author(s)
      副島英伸、城崎幸介、八木ひとみ、前田寿幸、大塚泰史、東元健
    • Organizer
      日本人類遺伝学会第56回大会・第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome2011

    • Author(s)
      Soejima H, Nakabayashi K, Yatsuki H, Jozaki K, Hata K, Higashimoto K
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Beckwith-Wiedemann症候群に間葉性異形成胎盤を合併し、両者のインプリンティング異常に乖離を呈した1例2011

    • Author(s)
      三好潤也、坂口勲、大場隆、片渕秀隆、副島英伸、東元健
    • Organizer
      遺伝医学合同学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Acquisition of aberrant hypermethylation after implantation induces discordant hypermethylation at H19-DMR between bodies and placentas in Beckwith-Wiedemann syndrome patients2011

    • Author(s)
      Soejima H, Nakabayashi K, Yatsuki H, Jozaki K, Hata K, Higashimoto K
    • Organizer
      Idibell Cancer Conferences on Imprinting and Beyond ;" Mono-allelic expression in Health and Disease
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析2011

    • Author(s)
      副島英伸、城崎幸介、八木ひとみ、前田寿幸、大塚泰史、東元健
    • Organizer
      遺伝医学合同学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] p57KIP2(KIP2)の遺伝子変異を認めたBeckwith-Wiedemann症候群(BWS)の1例2011

    • Author(s)
      岡田純一郎、東元健、八木ひとみ、芳野信、副島英伸、渡邊順子
    • Organizer
      第34回日本小児遺伝学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-11
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Beckwith-Wiedemann症候群に間葉性異形成胎盤を合併し、両者のインプリンティング異常に乖離を呈した1例2011

    • Author(s)
      三好潤也、岡島翠、松尾雄児、坂口勲、大場隆、片渕秀隆、東元健、副島英伸
    • Organizer
      第19回日本胎盤学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Histone H3 Lys36 methylation by Ash1l triggers a regulatory cascade of the chromatin reprogramming that counteracts Polycomb silencing2011

    • Author(s)
      Miyazaki H, Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Role of Ash1l for transcriptional pause release2010

    • Author(s)
      Higashimoto K
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] A role of histone methylation by ASH1L in the establishment of transcriptional memory2010

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      Cold Spring Harbor Conferences Asia(Epigenetics, Chromatin & Transcription)
    • Place of Presentation
      China
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析2010

    • Author(s)
      副島英伸、吉永北斗、東元健、八木ひとみ、前田寿幸、大塚泰史、中林一彦、秦健一郎、吉浦孝一郎
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      埼玉
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] インプリンティング疾患Beckwith-Wiedemann症候群本邦例の臨床像とゲノム・エピゲノム解析2010

    • Author(s)
      副島英伸、東元健
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Clinical features and genome/ epigenome analyses of Japanese patients with Beckwith-Wiedemann syndrome32010

    • Author(s)
      Yoshinaga H, Higashimoto K, Yatsuki H, Maeda T, Ohtsuka Y, Jozaki K, Nakabayashi K, Hata K, Yoshiura KI, Soejima H
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] 本邦Beckwith-Wiedemann症候群の臨床像とゲノム・エピゲノム解析2010

    • Author(s)
      吉永北斗、東元健、八木ひとみ、中林一彦、秦健一郎、吉浦孝一郎、副島英伸
    • Organizer
      第4回日本エピジェネティクス研究会年会
    • Place of Presentation
      鳥取
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] A role of histone methylation by Ash1L in the establishment of transcriptional memory.2010

    • Author(s)
      Higashimoto K
    • Organizer
      2010 Cold Spring Harbor Asia Conference "Epigenetics, Chromatin & Transcription"
    • Place of Presentation
      Suzhou, China
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] Role of Ash1l for transcriptional pause release2010

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] HISTONE METHYLATION BY MAMMALIAN ASH1L FACILITATES IN DUCTION OF HOX GENES IN RESPONSE TO RETINOIC ACID, THEREBY CONTRIBUTES TO ACQUISITION OF PROPER IDENTITIES OF CERVICAL VERTEBRAE.2009

    • Author(s)
      Higashimoto K
    • Organizer
      Cold Spring Harbor Meeting 2009 Mechanism of Eukaryotic Transcription
    • Place of Presentation
      NewYork
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健、八木ひとみ、岡田純一郎、渡邊順子、副島英伸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] HISTONE METHYLATION BY MAMMALIAN ASH1L FACILITATES IN DUCTION OF HOX GENES IN RESPONSE TO RETINOIC ACID, TH EREBY CONTRIBUTES TO ACQUISITION OF PROPER IDENTITIES OF CERVICAL VERTEBRA.2009

    • Author(s)
      東元健
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健、八木ひとみ、岡田純一郎、渡邊順子、副島英伸
    • Organizer
      第54回日本人類遺伝学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Histone methylation by mammalian Ash1l facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae2009

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      Cold Spring Harbor Meeting 2009 Mechanism of Eukaryotic Transcription
    • Place of Presentation
      New York, United States
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都)
    • Year and Date
      2009-09-25
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] H19メチル化インプリントが患児と胎盤で異なるBeckkwith-Wiedemann症候群の1例2009

    • Author(s)
      東元健
    • Organizer
      第16回日本遺伝子診療学会大会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] Beckwith-Wiedemann症候群の遺伝子診断2009

    • Author(s)
      西久保敏也、田中一郎、八木ひとみ、東元健、副島英伸、高橋幸博
    • Organizer
      第32回日本小児遺伝学会学術総会
    • Place of Presentation
      奈良
    • Year and Date
      2009-04-16
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] Histone methylation by mammalian Ash1l facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae2009

    • Author(s)
      Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21790340
  • [Presentation] H19-DMRのメチル化インプリントは正常発生過程で変化しうる2009

    • Author(s)
      東元健
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20590330
  • [Presentation] Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.

    • Author(s)
      Kenichi Nishioka、Hitomi Miyazaki, Ken Higashimoto, Yukari Yada, Takaho A. Endo, Jafar Sharif, Manabu Nakayama, Hidenobu Soejima, Haruhiko Koseki, Susumu Hirose.
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      伊藤国際学術研究センター(東京大学構内)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Data Source
      KAKENHI-PROJECT-25461554
  • [Presentation] Beckwith-Wiedemann症候群と肝芽腫におけるmultiple methylation defectの解析.

    • Author(s)
      前田寿幸、Rumbajan Janette Mareska、東元 健、中林一彦、八木ひとみ、秦健一郎、城圭一郎、副島英伸.
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      伊藤国際学術研究センター(東京大学構内)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Data Source
      KAKENHI-PROJECT-25461554
  • 1.  SOEJIMA Hidenobu (30304885)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 2.  JOH Keiichiro (90124809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  KUGOH Hiroyuki (40225131)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KOSEKI Haruhiko (40225446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KOMORI Toshihisa (00252677)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 6.  KISHINO Tatsuya (70315232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MIYAZAKI Toshihiro (10174161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  MATSUMOTO Naomichi (80325638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  YATSUKI Hitomi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  YOSHIURA koichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  KINOSHITA akira
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MISHIMA hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  MURATA yuzo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YASAKA toshiharu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  白石 哲也
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  OGATA Tsutomu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 17.  FUKAMI Maki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  北嶋 修司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  松久 葉一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  古川 圭子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  原 聡史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  半田 宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  田尻 達郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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