Shimizu-Hirota Ryoko 清水良子

… Alternative Names

清水良子シミズリョウコ

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Researcher Number	30348643
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2020: 慶應義塾大学, 医学部(信濃町), 専任講師(学部内) 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 助教 2017: 慶應義塾大学, 医学部, 助教 2016: 慶應義塾大学, 医学部(信濃町), 助教 … More 2013 – 2015: 慶應義塾大学, 医学部, 助教 2006: 慶應大, 医学部, 助手 2003 – 2005: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 55030:Cardiovascular surgery-related / Basic Section 54040:Metabolism and endocrinology-related / Cardiovascular surgery / Experimental pathology / Kidney internal medicine / Circulatory organs internal medicine Except Principal Investigator Basic Section 42040:Laboratory animal science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 55030:Cardiovascular surgery-related
Keywords	Principal Investigator 大動脈解離 / 細胞外基質 / Hippo経路 / 組織リモデリング / 脂肪ベージュ化 / リシルオキシダーゼ / 子宮 / 炎症 / p53 / p21 … More / p16 / 血管 / 細胞老化 / ＭＭＰ / MMP9 / ポドカン / 糖蛋白 / コラーゲン / MMP / 遺伝子導入 / 腎繊維化 / 細胞外マトリックス / トランスジェニックス / 細胞遊走 / 細胞増殖 / 血管平滑筋細胞 / 血管障害 / バイグリカン / プロテオグリカン … More Except Principal Investigator マウスモデル / 子宮内膜 / 不妊症 / 着床不全 / LIF / 着床 / 胚浸潤 / 子宮 / 卵管 / 細胞死 / 妊娠 / 子宮頸部細胞 / 着床障害 / 着床能 / バイオマーカー / 子宮頸部 / 大動脈解離 / リシルオキシダーゼ / RB遺伝子 / 管腔上皮 / 胚接着 / ネクロプトーシス / RB / 細胞増殖 / ポリコーム複合体 / ヒストン修飾 / 細胞外基質 / TNFα / プロゲステロン / ネクロトーシス / 細胞周期 / 子宮内膜上皮 / 網膜芽細胞腫遺伝子 / STAT3 / プロゲステロン受容体 / 細胞増殖能 / 胚着床 Less

Elucidation of the mechanisms of embryo-endometrial interactions induced by cell death
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
the role of Hippo pathway in the pathogenesis of acute aortic dissectionPrincipal Investigator
- Principal Investigator
  
  清水良子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Keio University
リシルオキシダーゼによる血管平滑筋細胞脱分化が大動脈解離発症に与える影響の検討
- Principal Investigator
  
  高石官均
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Keio University
Development of a new diagnostic method for implantation failure using cervical cells
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Mechanism of blastocyst invasion controlled by uterine factors
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
effect of lysyl oxidase-induced matrix rigidity change on fat browningPrincipal Investigator
- Principal Investigator
  
  Shimizu-Hirota Ryoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
Roles of cell proliferation and differentiation in the acquisition of uterine receptivity
- Principal Investigator
  
  Hirota Yasushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
the role of cellular senescence on the pathogenesis of acute aortic dissectionPrincipal Investigator
- Principal Investigator
  
  SHIMIZU-HIROTA Ryoko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Keio University
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissectionPrincipal Investigator
- Principal Investigator
  
  Shimizu-Hirota Ryoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
新規糖蛋白ポドカンのコラーゲン結合能を利用した腎線維化巣特異的遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  清水良子
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
プロテオグリカンによる血管障害発症機構の検討と治療への応用Principal Investigator
- Principal Investigator
  
  清水良子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2015 2013 2005 2004 Other

All Journal Article Presentation

[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023
- Author(s)
  Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Sakashita Akihiko、Shimizu-Hirota Ryoko、Takeda Norihiko、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Hiraoka Takehiro、Akaeda Shun、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 5 Pages: 320-320
- DOI
  10.1038/s41419-023-05832-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15814, KAKENHI-PROJECT-23K15827, KAKENHI-PROJECT-22K19596, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-23K23803
[Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Aikawa Shizu、Iida Rei、Ishizawa Chihiro、Kaku Tetsuaki、Hirata Tomoyuki、Fukui Yamato、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 5
- DOI
  10.1210/endocr/bqac044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-22K19596, KAKENHI-PROJECT-19H03796
[Journal Article] Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment2021
- Author(s)
  Fukui Yamato、Hirota Yasushi、Saito-Fujita Tomoko、Aikawa Shizu、Hiraoka Takehiro、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Ikawa Masahito、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 11
- DOI
  10.1210/endocr/bqab169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-21J00509, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19H03796
[Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Fukui Yamato、Gebril Mona、Kaku Tetsuaki、Aikawa Shizu、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 15523-15523
- DOI
  10.1038/s41598-020-72640-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09823, KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation2020
- Author(s)
  Gebril Mona、Hirota Yasushi、Aikawa Shizu、Fukui Yamato、Kaku Tetsuaki、Matsuo Mitsunori、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Shimizu-Hirota Ryoko、Takeda Norihiko、Taha Tamer、Balah Osama Al、Elnoury Mohamed Amr H、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 161 Issue: 12 Pages: 12-12
- DOI
  10.1210/endocr/bqaa195
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality2019
- Author(s)
  Haraguchi Hirofumi、Hirota Yasushi、Saito-Fujita Tomoko、Tanaka Tomoki、Shimizu-Hirota Ryoko、Harada Miyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Matsumoto Leona、Hirata Tetsuya、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 2 Pages: 2610-2620
- DOI
  10.1096/fj.201801401r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-18K19600, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-17J05930, KAKENHI-PROJECT-18K09284, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-19H03144
[Journal Article] Negative effect of fatty liver on visualization of pancreatic cystic lesions at screening transabdominal ultrasonography2019
- Author(s)
  Kashiwagi Kazuhiro、Seino Takashi、Makino Kanako、Shimizu‐Hirota Ryoko、Takayama Michiyo、Yoshida Toshifumi、Iwasaki Eisuke、Sugino Yoshinori、Inoue Nagamu、Iwao Yasushi、Kanai Takanori
- Journal Title
  
  Journal of Evaluation in Clinical Practice
  
  Volume: 印刷中 Issue: 1 Pages: 256-261
- DOI
  10.1111/jep.13138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10668
[Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018
- Author(s)
  Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 7 Pages: 3186-3197
- DOI
  10.1172/jci98931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-18K19600, KAKENHI-PROJECT-18K19601, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-17J05930, KAKENHI-PROJECT-18K09284, KAKENHI-PROJECT-17K16833, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-16K09493
[Journal Article] F4/80+ macrophages contribute to clearance of senescent cells in the mouse postpartum uterus.2017
- Author(s)
  Egashira M, Hirota Y, Shimizu-Hirota R, Saito-Fujita T, Haraguchi H, Matsumoto L, Matsuo M, Hiraoka T, Tanaka T, Akaeda S, Takehisa C, Saito-Kanatani M, Maeda K, Fujii T, Osuga Y.
- Journal Title
  
  Endocrinology
  
  Volume: 印刷中 Issue: 7 Pages: 2344-2353
- DOI
  10.1210/en.2016-1886
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15701, KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-17K16833, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-15J40160, KAKENHI-PROJECT-15K10660, KAKENHI-PROJECT-16K15700, KAKENHI-PROJECT-16H06279
[Journal Article] Investigation of Metabolic Factors Associated with eGFR Decline Over 1 Year in a Japanese Population without CKD2017
- Author(s)
  Hayashi K, Takayama M, Abe T, Kanda T, Hirose H, Shimizu-Hirota R, Shiomi E, Iwao Y, and Itoh H.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 8 Pages: 863-875
- DOI
  10.5551/jat.38612
- NAID
  130005876085
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08564, KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-16K19496
[Journal Article] Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.2015
- Author(s)
  Anzai A, Shimoda M, Endo J, Kohno T, Katsumata Y, Matsuhashi T, Yamamoto T, Ito K, Yan X, Shirakawa K, Shimizu-Hirota R, Yamada Y, Ueha S, Shinmura K, Okada Y, Fukuda K, Sano M.
- Journal Title
  
  Circ Res
  
  Volume: 116 Issue: 4 Pages: 612-623
- DOI
  10.1161/circresaha.116.304918
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293113, KAKENHI-PROJECT-25460491, KAKENHI-PROJECT-25870718
[Journal Article] トランスジェニックマウスを用いた細胞外マトリックス糖蛋白質バイグリカンの血管における昨日の検討2005
- Author(s)
  清水良子, 篠村裕之, 猿田享男
- Journal Title
  
  血圧 12
  
  Pages: 351-356
- Data Source
  KAKENHI-PROJECT-15790392
[Journal Article] Functional characterization of podocan, a member of a new class in the small leucine-rich repeat protein family2004
- Author(s)
  Shimizu-Hirota R, Sasamura H, Kuroda m, Kobayashi E, Hayashi M, Saruta T
- Journal Title
  
  FEBS Letters 563
  
  Pages: 69-74
- Data Source
  KAKENHI-PROJECT-15790392
[Journal Article] Estracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration.2004
- Author(s)
  SHimizu-Hirota R, Sasamura H, Kuroda M, Kobayashi E, Hayashi M, Saruta T.
- Journal Title
  
  Circulation Research 94
  
  Pages: 1067-1074
- Data Source
  KAKENHI-PROJECT-15790392
[Presentation] 細胞老化が急性大動脈解離発症に与える影響の検討2019
- Author(s)
  清水良子
- Organizer
  第４２回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K10668
[Presentation] F4/80陽性マクロファージによるマウス分娩後子宮の老化細胞除去と次回妊娠に及ぼす影響2017
- Author(s)
  清水良子
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K10668
[Presentation] 好中球由来MMP9が急性大動脈解離を誘発する2015
- Author(s)
  清水良子
- Organizer
  日本内分泌学会総会
- Place of Presentation
  ホテルニューオータニ東京 (東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25870718
[Presentation] 好中球由来ＭＭＰ９を介した急性大動脈解離の発症機構2013
- Author(s)
  清水良子
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  大阪千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25870718
[Presentation] 好中球由来ＭＭＰ９を介した急性大動脈解離の発症機構2013
- Author(s)
  清水良子
- Organizer
  日本血管生物医学会
- Place of Presentation
  大阪千里阪急ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-25870718
[Presentation] 好中球由来ＭＭＰ９を介した急性大動脈解離の発症機構2013
- Author(s)
  清水良子
- Organizer
  日本高血圧学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-25870718
[Presentation] 好中球由来MMP9が急性大動脈解離を誘発する
- Author(s)
  清水良子
- Organizer
  日本内分泌学会
- Place of Presentation
  ホテルニューオータニ
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-25870718

1. Hirota Yasushi (40598653)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 槇野香奈子 (10772402)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. 藍川志津 (80884577)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 松尾光徳 (00823618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 赤枝俊 (10898084)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 原口広史 (50804506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金谷真由子 (60748862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高石官均 (80286468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平岡毅大 (20836762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. UEHA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 齊藤知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 吉野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 平田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大須賀穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu-Hirota Ryoko 清水 良子

清水 良子 シミズ リョウコ

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanisms of embryo-endometrial interactions induced by cell death

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

the role of Hippo pathway in the pathogenesis of acute aortic dissectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リシルオキシダーゼによる血管平滑筋細胞脱分化が大動脈解離発症に与える影響の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new diagnostic method for implantation failure using cervical cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of blastocyst invasion controlled by uterine factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

effect of lysyl oxidase-induced matrix rigidity change on fat browningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of cell proliferation and differentiation in the acquisition of uterine receptivity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

the role of cellular senescence on the pathogenesis of acute aortic dissectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規糖蛋白ポドカンのコラーゲン結合能を利用した腎線維化巣特異的遺伝子治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロテオグリカンによる血管障害発症機構の検討と治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022

Author(s)

Journal Title

DOI

Shimizu-Hirota Ryoko 清水良子

清水良子シミズリョウコ