HARADA TAKESHI 原田武志

… Alternative Names

Takeshi Harada 原田武志

Harada Takeshi 原田武志

HARADA Takeshi 原田武志

Less

Researcher Number	30362768
Other IDs
Affiliation (Current)	2025: アンジェス株式会社, 社長室, 次長/主席研究員
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 大学院医学系研究科, 助教 2019 – 2021: 大阪大学, 医学系研究科, 助教 2017 – 2018: 大阪大学, 医学系研究科, 特任助教(常勤) 2016: 大阪大学, 医学(系)研究科(研究院), 助教 2010 – 2012: 東京大学, 大学院・医学系研究科, 助教 … More 2007: Kobe University, 医学系研究科, 助教 2007: Kobe University, Graduate School of Medicine, Assistant Professor 2006: 神戸大学, 医学系研究科, 助手 2005 – 2006: 神戸大学, 大学院医学系研究科, 助手 2005: 神戸大学, 大学院・医学研究科, 助手 2003 – 2005: Kobe University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / General medical chemistry / Biological Sciences / Neuroscience in general Except Principal Investigator Neuroscience in general / Biological Sciences / Tumor biology / Neuroscience in general / Neuroscience in general
Keywords	Principal Investigator トランスジェニックマウス / ノックアウトマウス / 老化 / 神経変性疾患 / 肝臓 / 脂質 / 小胞体 / ミトコンドリア / CKAP4 / 生体分子 … More / CRISPR / シングルセル解析 / 線維芽細胞 / ライブイメージング / Wnt5a / MEK / シグナル伝達 / 光刺激 / 可塑性 / Arc / 眼優位性 / 臨界期 / 視覚野 / MAPキナーゼ / ERK / アクチン細胞骨格 / Cre / プルキンエ細胞 / 低分子量Gタンパク質 / Rhoファミリー / Rac … More Except Principal Investigator L7 / トランスジェニックマウス / mGluR1 / Cdc42 / RGS / o / Gi / cerebellum / Purkinje cell / 小脳 / Cre / プルキンエ細胞 / 炎症 / がん / Wnt5a / cerebral cortex / Rho family / knockout mice / Ella-Cre / cdc42 / 大脳皮質 / Rhoファミリー / ノックアウトマウス / insulator / transgenic mouse / pertusis toxin / インスレーター / 百日咳毒素 / 小脳プルキンエ細胞 / hippocampus / transgenic mice / tetracycline / glutamate receptor / グルタミン受容体 / ドキシサイクリン / tTA / フルキンエ細胞 / 海馬 / テトラサイクリン / グルタミン酸受容体 / 神経科学 / シグナル伝達 / 遺伝学 / 脳・神経 / テオラサイクリン / トランスジェニック / コンディショナルノックアウト / 浸潤 / 発がん / 基底細胞 / Rac1 / 登上線維 / Vesl / Homer / mGluR1b / 運動協調 Less

Functional analysis of type II membrane protein CKAP4 at the individual levelPrincipal Investigator
- Principal Investigator
  
  Takeshi Harada
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka University
In vivo imaging of a secreted glycoprotein, Wnt5aPrincipal Investigator
- Principal Investigator
  
  Harada Takeshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
Wnt5aシグナルネットワークの異常によるがんと炎症の悪性化の分子機構の解明
- Principal Investigator
  
  菊池章
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  Osaka University
Roles of mTOR in neuronal development, synaptic plasticity and learning and memory
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo
大脳皮質視角野の臨界期可塑性におけるMAPキナーゼのin vivoでの機能解析Principal Investigator
- Principal Investigator
  
  原田武志
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University
mGluR1トランスジェニックマウスを用いた神経可塑性の研究
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
コンディショナルRac欠損マウスを用いた発がんの研究
- Principal Investigator
  
  饗場篤
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
低分子量Gタンパク質Rac3のノックアウトマウスの作製と解析Principal Investigator
- Principal Investigator
  
  原田武志
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University
Investigation of signal transduction in cerebellar Purkinje cell by in vivo expression of pertusis toxin.
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University
Analysis of cerebellar function by using inducible mGluRl transgenic mice.
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University

All 2023 2021 2020 2019 2018 2017 2011 2010 2007

All Journal Article Presentation

[Journal Article] Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload2023
- Author(s)
  Kishimoto Hiroshi、Iwasaki Masayoshi、Wada Kensaku、Horitani Keita、Tsukamoto Osamu、Kamikubo Kenta、Nomura Seitaro、Matsumoto Shinji、Harada Takeshi、Motooka Daisuke、Okuzaki Daisuke、Takashima Seiji、Komuro Issei、Kikuchi Akira、Shiojima Ichiro
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 7 Pages: 107146-107146
- DOI
  10.1016/j.isci.2023.107146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07357, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-23K24336, KAKENHI-PROJECT-23K27671
[Journal Article] ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target2020
- Author(s)
  Kimura Kenji、Matsumoto Shinji、Harada Takeshi、Morii Eiichi、Nagatomo Izumi、Shintani Yasushi、Kikuchi Akira
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 3 Pages: 951-961
- DOI
  10.1111/cas.14303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-18K06956, KAKENHI-PROJECT-19K22563, KAKENHI-PUBLICLY-18H04861, KAKENHI-PUBLICLY-18H05101, KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-16H06374
[Journal Article] Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER?mitochondria contact sites2020
- Author(s)
  Harada Takeshi、Sada Ryota、Osugi Yoshito、Matsumoto Shinji、Matsuda Tomoki、Hayashi-Nishino Mitsuko、Nagai Takeharu、Harada Akihiro、Kikuchi Akira
- Journal Title
  
  Journal of Cell Science
  
  Volume: 133 Issue: 21
- DOI
  10.1242/jcs.249045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06956, KAKENHI-PROJECT-20K07357, KAKENHI-PROJECT-16H06374, KAKENHI-PROJECT-18H02594, KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-19K22563, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422
[Journal Article] Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing2019
- Author(s)
  Kumita Wakako、Sato Kenya、Suzuki Yasuhiro、Kurotaki Yoko、Harada Takeshi、Zhou Yang、Kishi Noriyuki、Sato Kengo、Aiba Atsu、Sakakibara Yasubumi、Feng Guoping、Okano Hideyuki、Sasaki Erika
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12719-12719
- DOI
  10.1038/s41598-019-49110-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-19K06462
[Journal Article] CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy2019
- Author(s)
  Kimura Hirokazu、Yamamoto Hideki、Harada Takeshi、Fumoto Katsumi、Osugi Yoshihito、Sada Ryota、Maehara Natsumi、Hikita Hayato、Mori Soichiro、Eguchi Hidetoshi、Ikawa Masahito、Takehara Tetsuo、Kikuchi Akira
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 25 Issue: 6 Pages: 1936-1947
- DOI
  10.1158/1078-0432.ccr-18-2124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-18K06930, KAKENHI-PROJECT-18K15064, KAKENHI-PUBLICLY-18H04861, KAKENHI-PUBLICLY-18H05101, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22563, KAKENHI-PROJECT-16H06374
[Journal Article] Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth2019
- Author(s)
  Harada Takeshi、Matsumoto Shinji、Hirota Suguru、Kimura Hirokazu、Fujii Shinsuke、Kasahara Yuuya、Gon Hidetoshi、Yoshida Toshihiko、Itoh Tomoo、Haraguchi Naotsugu、Mizushima Tsunekazu、Noda Takehiro、Eguchi Hidetoshi、Nojima Satoshi、Morii Eiichi、Fukumoto Takumi、Obika Satoshi、Kikuchi Akira
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 18 Issue: 3 Pages: 602-612
- DOI
  10.1158/1535-7163.mct-18-0824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-18K06956, KAKENHI-PUBLICLY-18H05101, KAKENHI-PROJECT-15K08272, KAKENHI-PROJECT-16K11501, KAKENHI-PROJECT-18K15064, KAKENHI-PROJECT-16H06374
[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2011
- Author(s)
  Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
- Journal Title
  
  AMech Dev
  
  Volume: (In press) Issue: 1-4 Pages: 38-50
- DOI
  10.1016/j.mod.2012.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01113, KAKENHI-PROJECT-22249061, KAKENHI-PROJECT-22300106, KAKENHI-PROJECT-22890180, KAKENHI-PROJECT-23390417, KAKENHI-PROJECT-23592748, KAKENHI-PROJECT-23650214, KAKENHI-PROJECT-23659855, KAKENHI-PROJECT-23700368
[Presentation] AOM/DSS大腸がんマウスモデルにおけるWnt5a発現線維芽細胞サブセットの同定2021
- Author(s)
  原田武志、原田昭和、香山尚子、佐藤朗、菊池章
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07357
[Presentation] パルミトイル化CKAP4はVDAC2を介してミトコンドリア機能を制御する2020
- Author(s)
  原田武志、佐田僚太、大杉祥仁、松本真司、菊池章
- Organizer
  第93回　日本生化学学会大会
- Data Source
  KAKENHI-PROJECT-17K08633
[Presentation] パルミトイル化CKAP4はVDAC2を介してミトコンドリア機能を制御する2020
- Author(s)
  原田武志、佐田僚太、大杉祥仁、松本真司、菊池章
- Organizer
  第93回日本生化学大会
- Data Source
  KAKENHI-PROJECT-20K07357
[Presentation] CKAP4-VDAC2相互作用によるミトコンドリア機能の制御2019
- Author(s)
  原田武志、松本真司、大杉祥仁、菊池章
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08633
[Presentation] 小胞体―ミトコンドリア連携ゾーンにおけるII型膜タンパク質CKAP4の機能解析2018
- Author(s)
  原田武志、大杉祥仁、松本真司、菊池章
- Organizer
  第91回日本生化学大会
- Data Source
  KAKENHI-PROJECT-17K08633
[Presentation] Wnt5b含有エソソームは癌細胞の増殖及び運動能を亢進させる2017
- Author(s)
  原田武志
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08633
[Presentation] ERKは歯状回顆粒細胞の生存に必要である2010
- Author(s)
  原田武志
- Organizer
  日本神経科学学会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22300106
[Presentation] ERKは歯状回顆粒細胞の生存に必要である2010
- Author(s)
  原田武志
- Organizer
  日本神経科学学会第33回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県神戸市)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22300106
[Presentation] ERKは恐怖記憶の形成に必要である。2007
- Author(s)
  原田武志
- Organizer
  Neuro2007(第30回日本神経科学大会)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18019026

1. AIBA Atsu (20271116)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MATSUDA Ikuo (50335452)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 新石健二 (40362769)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KASSAI Hidetoshi (40403232)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NODA Asao (40294227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AIBA(FUSUSEN) Naomi (50199220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 菊池章 (10204827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐藤朗 (70464302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松本真司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARADA TAKESHI 原田 武志

Takeshi Harada 原田 武志

Harada Takeshi 原田 武志

HARADA Takeshi 原田 武志

Research Projects

Research Products

Co-Researchers

Functional analysis of type II membrane protein CKAP4 at the individual levelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vivo imaging of a secreted glycoprotein, Wnt5aPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Wnt5aシグナルネットワークの異常によるがんと炎症の悪性化の分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of mTOR in neuronal development, synaptic plasticity and learning and memory

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

大脳皮質視角野の臨界期可塑性におけるMAPキナーゼのin vivoでの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

mGluR1トランスジェニックマウスを用いた神経可塑性の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

コンディショナルRac欠損マウスを用いた発がんの研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

低分子量Gタンパク質Rac3のノックアウトマウスの作製と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of signal transduction in cerebellar Purkinje cell by in vivo expression of pertusis toxin.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cerebellar function by using inducible mGluRl transgenic mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target2020

Author(s)

HARADA TAKESHI 原田武志

Takeshi Harada 原田武志

Harada Takeshi 原田武志

HARADA Takeshi 原田武志