Shimizu Naomi 清水直美

… Alternative Names

SHIMIZU Naomi 清水直美

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Researcher Number	30375802
Other IDs
Affiliation (Current)	2025: 東邦大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016: 東邦大学, 医学部, 講師 2014: 東邦大学, 医学部, 講師 2012 – 2013: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Metabolomics / Laboratory medicine
Keywords	Principal Investigator CD71 / GATA2 / GATA1 / WT1 / プロテアーゼ / 転写因子 / 白血病 / G-CSF / LR11 Except Principal Investigator 褐色脂肪 … More / LR11 / 皮下脂肪 / 可溶性LR11 / ノックアウトマウス / インスリン抵抗性 / 褐色分化 / 熱代謝 / 糖尿病 / 肥満 / 機能獲得 / 褐色細胞 / エネルギー消費 / 熱産生 / 基礎代謝 / 黄斑前膜 / 肺高血圧 / アルツハイマー病 / 肺高血圧症 / リンパ腫 / 検査マーカー / 病的細胞 / ＬＲ１１ / 可溶性 Less

Identification of the pathologically-transited immature cells diagnosed by soluble LR11
- Principal Investigator
  
  BUJO Hideaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Toho University
Molecular basis of the severe ectopic browning transition of adipocytes in novel mice with resistance against obesity and diabetes
- Principal Investigator
  
  JIANG Meizi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Toho University
Analysis of the differentiation control factor of leukemia, PRDM16 and physiological inhibitor LR11Principal Investigator
- Principal Investigator
  
  SHIMIZU Naomi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Toho University
  Chiba University

All 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Prognostic impact of serum soluble LR11 in newly diagnosed diffuse large B-cell lymphoma: A multicenter prospective analysis.2016
- Author(s)
  Sugita Y, Ohwada C, Kawaguchi T, Muto T, Tsukamoto S, Takeda Y1, Mimura N, Takeuchi M , Sakaida E, Shimizu N, Tanaka H, Abe D, Fukazawa M, Sugawara T, Aotsuka N, Nishiwaki K, Shono K, Ebinuma H, Fujimura K, Bujo H, Yokote K, Nakaseko C.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 463 Pages: 47-52
- DOI
  10.1016/j.cca.2016.10.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15198
[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015
- Author(s)
  Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: 印刷中 Issue: 10 Pages: 1-4
- DOI
  10.3109/10428194.2015.1016930
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
[Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow2014
- Author(s)
  Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H
- Journal Title
  
  Ann Hematol
  
  Volume: (印刷中) Issue: 7 Pages: 1111-1122
- DOI
  10.1007/s00277-014-2033-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380
[Journal Article] Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes.2014
- Author(s)
  Tsukamoto S, Takeuchi M, Kawaguchi T, Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C.
- Journal Title
  
  Exp Mol Med.
  
  Volume: - Issue: 4 Pages: 46-89
- DOI
  10.1038/emm.2013.161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-26461369
[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
- Journal Title
  
  Leuk Lymphoma
  
  Volume: (印刷中) Issue: 10 Pages: 2391-2394
- DOI
  10.3109/10428194.2014.880430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409
[Journal Article] Circulating LR11 is a novel soluble-receptor marker for early-stage clinical conditions in patients with non-Hodgkin's lymphoma.2014
- Author(s)
  Fujimura K, Ebinuma H, Fukamachi I, Ohwada C, Kawaguchi T, Shimizu N, Takeuchi M, Sakaida E, Jiang M, Nakaseko C, Bujo H.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 430 Pages: 48-54
- DOI
  10.1016/j.cca.2013.12.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591380
[Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
- Journal Title
  
  Br J Haematol
  
  Volume: 163(2) Issue: 2 Pages: 277-280
- DOI
  10.1111/bjh.12467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
[Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013
- Author(s)
  Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288(17) Issue: 17 Pages: 11877-11886
- DOI
  10.1074/jbc.m112.442491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591368, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24790907
[Journal Article] Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias2012
- Author(s)
  Sakai S, Nakaseko C, Takeuchi M, Ohwada C, Shimizu N, Tsukamoto S, Kawaguchi T, Jiang M, Sato Y, Ebinuma H, Yokote K, Iwama A, Fukamachi I, Schneider WJ, Saito Y, Bujo H.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 96 Issue: 19-20 Pages: 542-1548
- DOI
  10.1016/j.cca.2012.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24790907
[Presentation] Tetraspanin CD9 inhibited ADAM17-mediated LR11 shedding in leukemia cell lines.2013
- Author(s)
  Shokichi Tsukamoto, Masahiro Takeuchi, Takeharu Kawaguchi, Emi Togasaki, Atsuko Yamazaki, Yasumasa Sugita, Tomoya Muto, Shio Sakai, Yusuke Takeda, Chikako Ohwada, Naomi Shimizu, Emiko Sakaida, Keigo Nishii, Jiang Meizi, Tohru Iseki, Koutaro Yokote, Hideaki Bujo, Chiaki Nakaseko.
- Organizer
  The 55rd Annual Meeting og the American Society of Hematology
- Place of Presentation
  New Orleans(USA)
- Data Source
  KAKENHI-PROJECT-24591380
[Presentation] Soluble form of LR11 is highly espressed on myeloid cells after G-CSF treatment.2012
- Author(s)
  Naomi Shimizu, Hideaki Bujo, Shio Sakai, Shokichi Tsukamoto, Takeharu Kawaguchi, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Emiko Sakaida, Keigo Nishi, Meizi Jiang, Chiaki Nakaseko.
- Organizer
  The 74th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-24591380
[Presentation] Soluble LR11, a novel acute leukemia marker, drastically induces WT1 mRNA expression together with synergic activation of GATAs, and the migration activity.2012
- Author(s)
  Naomi Shimizu, Chiaki Nakaseko, Masahiro Takeuchi, Chikako Ohwada, Shokichi Tsukamoto, Keigo Nishii, Meiji Jiang, Koutaro Yokote, Isamu Fukamachi, Hideaki Bujo.
- Organizer
  The 53rd Annual Meeting of the American Society of Hematology
- Place of Presentation
  Atlanta(USA)
- Data Source
  KAKENHI-PROJECT-24591380
[Presentation] Tetraspanin CD9 regulates ADAM17-mediated LR11 shedding in leukemia cells.2012
- Author(s)
  Shokichi Tsukamoto, Masahiro Takeuchi, Atsuko Yamazaki, Takeharu Kawaguchi, Chikako Ohwada, Naomi Shimizu, Emiko Sakaida, Keigo Nishi, Meizi Jiang, Hideaki Bujo, Chiaki Nakaseko.
- Organizer
  The 74th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-24591380

1. BUJO Hideaki (80291300)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. JIANG Meizi (00624066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HIRUTA Nobuyuki (50201736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGAO Tateki (20167555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKASEKO Chiaki (30323398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. IKEUCHI Takeshi (20372469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HIGASHI Morihiko (00323395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Antonio Vidal-Puig

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 田丸淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 横手幸太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 武内正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Naomi 清水 直美

SHIMIZU Naomi 清水 直美

Research Projects

Research Products

Co-Researchers

Identification of the pathologically-transited immature cells diagnosed by soluble LR11

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of the severe ectopic browning transition of adipocytes in novel mice with resistance against obesity and diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the differentiation control factor of leukemia, PRDM16 and physiological inhibitor LR11Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prognostic impact of serum soluble LR11 in newly diagnosed diffuse large B-cell lymphoma: A multicenter prospective analysis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating LR11 is a novel soluble-receptor marker for early-stage clinical conditions in patients with non-Hodgkin's lymphoma.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Tetraspanin CD9 inhibited ADAM17-mediated LR11 shedding in leukemia cell lines.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Soluble form of LR11 is highly espressed on myeloid cells after G-CSF treatment.2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Soluble LR11, a novel acute leukemia marker, drastically induces WT1 mRNA expression together with synergic activation of GATAs, and the migration activity.2012

Author(s)

Shimizu Naomi 清水直美

SHIMIZU Naomi 清水直美