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MIZUSHIMA Hiroto  水島 寛人

ORCIDConnect your ORCID iD *help
Researcher Number 30379094
Other IDs
Affiliation (Current) 2022: 大阪大学, 微生物病研究所, 特任講師(常勤)
Affiliation (based on the past Project Information) *help 2016: 大阪大学, 微生物病研究所, 助教
2011 – 2014: 大阪大学, 微生物病研究所, 助教
2009: 大阪大学, 微生物病研究所, 助教
2007: Osaka University, Research Institute for Microbial Disease, Assistant Professor
2004 – 2006: 大阪大学, 微生物病研究所, 助手
Review Section/Research Field
Principal Investigator
Cell biology
Except Principal Investigator
Cell biology / Biological Sciences / Tumor therapeutics
Keywords
Principal Investigator
増殖因子 / 細胞接着 / 細胞増殖 / 細胞骨格
Except Principal Investigator
HB-EGF / EGFR / 細胞増殖因子 / siRNA / ADAM / エクトドメインシェディング … More / ectodomain shedding / 3次元増殖 / EGF / インテグリン / 腫瘍形成 / 細胞外マトリックス / sHRNA / CRM197 / 癌間質 / 3次元環境 / EGFファミリー / 増殖機構 / エクトドメインシェディン / プロテアーゼ / シグナル伝達 / protease / DNAアレイ / シェディング / レンチウィルス / SiRNA / DNA aray / ErbB4 / 増殖抑制 / EGF受容体 / マイコプラズマ Less
  • Research Projects

    (5 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (8 People)
  •  Development of a novel anti-cancer therapeutics targeting HB-EGF

    • Principal Investigator
      MEKADA EISUKE
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Osaka University
  •  Integration and regulatory mechanism for growth factor and cell adhesion signalsPrincipal Investigator

    • Principal Investigator
      MIZUSHIMA Hiroto
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Identification of genes involved in the ectodomain sheddingof HB-EGF

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  Cell function regulation by membrane-anchored growth factors

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Analysis of the ectodomain shedding mechanism of HB-EGF

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University

All 2017 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.2017

    • Author(s)
      Iwamoto R, Mine N, Mizushima H, Mekada E
    • Journal Title

      J. Cell Sci.

      Volume: 130 Pages: 1321-1332

    • DOI

      10.1242/jcs.196618

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-15K07046
  • [Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.2015

    • Author(s)
      Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
    • Journal Title

      J Biochem.

      Volume: mvu079 Pages: 1-13

    • DOI

      10.1093/jb/mvu079

    • NAID

      40020461422

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23570227, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26460525, KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
  • [Journal Article] HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers2011

    • Author(s)
      Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.
    • Journal Title

      Cancer Res.

      Volume: 71 (21) Pages: 6633-6642

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570227
  • [Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.2011

    • Author(s)
      Koshikawa,N., Mizushima,H., Minegishi,T., Eguchi,F., Yotsumoto,F., Nabeshima,K. Miyamoto,S., Mekada,E., Seiki,M
    • Journal Title

      Cancer Sci. 102

      Pages: 111-116

    • NAID

      10029288679

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin -independent growth factor.2010

    • Author(s)
      Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. Seiki,M
    • Journal Title

      Cancer Res. 70

      Pages: 6093-6103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009

    • Author(s)
      Mizushima,H., Wang,X., Miyamoto,S., Mekada,E.
    • Journal Title

      J. Cell Sci. 122

      Pages: 4277-4286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009

    • Author(s)
      Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
    • Journal Title

      J.Cell Sci. 122

      Pages: 4277-4286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009

    • Author(s)
      Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
    • Journal Title

      J.Cell Sci.

      Volume: 122 Pages: 4277-4286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.2007

    • Author(s)
      Kageyama,T., Ohishi,M., Miyamoto,S., Mizushima,H., Iwamoto,R. Mekada,E
    • Journal Title

      J.Biochem. 142

      Pages: 95-104

    • NAID

      10020098014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity2007

    • Author(s)
      Kageyama, T., Ohishi, M., Miyamoto, S., Mizushima, H., Iwamoto, R., Mekada, E
    • Journal Title

      J. Biochem 142

      Pages: 95-104

    • NAID

      10020098014

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370079
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang,X., Mizushima,H., Adachi,S., Ohishi,M., Iwamoto,R., Mekada,E.
    • Journal Title

      Cell Struct. Funct. 31

      Pages: 15-27

    • NAID

      130004053854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006

    • Author(s)
      Kakumoto, K., Sasai, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., Akagi, T.
    • Journal Title

      Proc.Natl.Acad.Sci. USA103

      Pages: 5490-5495

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
    • Journal Title

      Cell Struct.Funct. 31

      Pages: 15-27

    • Data Source
      KAKENHI-PROJECT-18370079
  • [Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006

    • Author(s)
      Kakumoto,K., Sasai,K., Sukezane,T., Oneyama,C., Ishimaru,S., Shibutani,K., Mizushima,H., Mekada E., Hanafusa,H. Akagi,T
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 5490-5495

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
    • Journal Title

      Cell Struct.Funct. 31

      Pages: 15-27

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct.Funct. (in press.)

    • NAID

      130004053854

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006

    • Author(s)
      Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
    • Journal Title

      Cell Struct.Funct. (in press)

    • NAID

      130004053854

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006

    • Author(s)
      Kakumoto, K., Sasai, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., Akagi,T.
    • Journal Title

      Proc.Natl.Acad.Sci. USA103

      Pages: 5490-5495

    • Data Source
      KAKENHI-PROJECT-18370079
  • [Journal Article] Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.2005

    • Author(s)
      Tanaka, T., Miyamoto, S., Suzuki, S.O., Oki, E., Yagi, H., Sonoda, K., Yamazaki, A., Mizushima, H., Maehara, Y., Mekada, E., Nakano, H.
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 4783-4792

    • Data Source
      KAKENHI-PROJECT-16207014
  • [Journal Article] Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.2005

    • Author(s)
      Tanaka, T., Miyamoto, S., Suzuki, S.O., Oki, E., Yagi, H., Sonoda, K., Yamazaki, A., Mizushima, H., Maehara, Y., Mekada, E., Nakano, H.
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 4783-4792

    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御2014

    • Author(s)
      水島寛人、船越敍希、目加田英輔
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-11
    • Data Source
      KAKENHI-PROJECT-26250033
  • [Presentation] Sequestration of FAK on microtubule negatively regulates HB-EGF-dependent cell growth2013

    • Author(s)
      Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      ウインクあいち(愛知県産業労働センター)
    • Data Source
      KAKENHI-PROJECT-23570227
  • [Presentation] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers2012

    • Author(s)
      Hiroto Mizushima, Takuya Murata, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto, Eisuke Mekada
    • Organizer
      第45回日本発生学会、第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-23570227
  • [Presentation] インテグリンシグナルはEGFファミリー増殖因子の増殖因子活性を単層培養において不顕在化する2009

    • Author(s)
      水島寛人、宮本新吾、目加田英輔
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17014057
  • [Presentation] Regulation of HB-EGF-dependent cell growth by phosphorylation of FERM domain of FAK

    • Author(s)
      Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学クラーク会館、学術交流会館(北海道)
    • Data Source
      KAKENHI-PROJECT-23570227
  • [Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御

    • Author(s)
      水島寛人、船越敍希、目加田英輔
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-23570227
  • 1.  MEKADA Eisuke (20135742)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 26 results
  • 2.  IWAMOTO Ryo (10213323)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 3.  ASANO Shiro (00397613)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  NAKAMURA Kuniaki (70311305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  NAKAMURA Takashi (00570673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  YONEDA Tomoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ABE Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  中村 春木
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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